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Gonzalez Filipe André FA Department of Internal Medicine, Hospital Garcia de Orta, Almada, - - 2014
A 24-year-old man presented to the emergency department with fever, maculopapular rash, myalgia and polyarthralgia, thoracic pain and dry cough, which had been present for 24 h. At the time of observation he had high fever (39°C), maculopapular rash on the torso, arms and legs proximally, axillary adenopathies and pharyngitis. Laboratorial ...
Filopanti M M Endocrinology and Diabetology Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Padiglione Granelli via F. Sforza 35, 20122 Milan, - - 2014
Hepatotoxicity is one of the most serious adverse effects in acromegalic patients treated with pegvisomant (PEG-V). Recent studies have found an association between this adverse event and the UGT1A1 allele 28 polymorphism associated with Gilbert's syndrome. To determine whether UGT1A1*28 and alcohol dehydrogenase (ADH) polymorphisms influence liver toxicity during PEG-V ...
Anyfantakis Dimitrios - - 2013
The aim of this study was to analyse data relating to the liver function profile during acute infection from murine typhus in the city of Chania in the island of Crete (Greece). A retrospective study of the files of all the cases with a diagnosis of murine typhus admitted to ...
Cheah Chan Y - - 2013
Rasburicase is frequently used in tumor lysis syndrome (TLS). Although it is very well tolerated, it can cause severe oxidative hemolytic anemia and methemoglobinemia in patients with glucose-6-phosphate dehydrogenase (G6PD) deficiency. We report another case of rasburicase-induced methemoglobinemia in a patient with previously unrecognized G6PD deficiency and review the cases ...
William Basem Magdy - - 2013
Serum lactate dehydrogenase is a non-specific marker for lymphoma whose prognostic significance is well established for both indolent and aggressive lymphomas at the time of diagnosis. The performance characteristics of this enzyme in predicting relapse in patients with diffuse large B-cell lymphoma has not been well studied. This study compared ...
Stav Kobi - - 2012
PURPOSE: We determined whether swallowing has an effect on the degree of urinary urgency and on the amplitude of detrusor contraction during filling cystometry in patients with detrusor overactivity. MATERIALS AND METHODS: Included in study were 20 consecutive patients with detrusor overactivity. During urodynamics the mean peak pressure of each ...
Hong Ji Heon - - 2012
: Little is known about the usefulness and findings of brain herniation on diffusion tensor tractography (DTT). Using DTT, we demonstrated neural tract injuries in 2 patients who showed subfalcine and trasntentorial herniations after subdural hematoma resulting from motor vehicle accident. : Two patients and 6 age- and sex-matched, healthy ...
Jang Woo Sun - - 2012
Linear focal elastosis (LFE) is characterized by several asymptomatic, yellow, palpable, irregularly indurated, striae-like lines extending horizontally across the middle and lower back. A focal increase in elastic fibers is a hallmark of the disease as seen from biopsy specimens. The pathogenesis of LFE is unclear, as is the association ...
Postma Mark Roland - - 2012
Objective: To assess the influence of long-acting somatostatin analogs (SSTA) after initial pituitary surgery on long-term health-related quality of life (HR-QoL) in relation to disease control in patients with acromegaly.Design: This is a cross-sectional study in two tertiary referral centers in the Netherlands.Patients and methods: 108 patients with acromegaly, in ...
Spiekerkoetter U - - 2012
Newborn screening identifies patients with very long-chain acyl-CoA dehydrogenase (VLCAD) deficiency with disease-specific acylcarnitine profiles. We here present a patient who died at 16 months during a gastrointestinal infection because of undiagnosed VLCADD. The primary acylcarnitine profile on newborn screening performed at 55 h of life revealed C14-acylcarnitine values and ...
Kasperkiewicz Michael - - 2011
BACKGROUND: Dermatitis herpetiformis (DH) is a cutaneous manifestation of celiac disease (CD), the latter being identified by circulating autoantibodies against native gliadin (nGli), tissue transglutaminase (tTG), endomysium, or a combination of these. Recently, a novel serologic assay using deamidated gliadin-analogous fusion peptides (GAF3X) showed high diagnostic sensitivity in patients with ...
Liao Yu-Ying - - 2011
Nonoperative management for selective patients with solid organ injuries from blunt trauma has gained wide acceptance. However, for trauma surgeons, it is often difficult to estimate a patient's circulatory volume. Some authors have proposed that the presence of a collapsed inferior vena cava (IVC) on computed tomography (CT) scan correlates ...
Hofstra Jorrit J - - 2011
Pulmonary coagulopathy is intrinsic to pneumonia and other forms of acute lung injury. We hypothesized patients with burn injuries and inhalation trauma to have similar alterations in pulmonary coagulation and fibrinolysis. We performed a prospective study on changes in pulmonary and systemic thrombin generation and fibrinolytic activity in patients with ...
Puoti C - - 2011
Rapid virological response (RVR) is now considered the strongest predictor of sustained virological response (SVR) in patients with HCV undergoing antiviral treatment, and thus, shorter antiviral treatment for these patients has been suggested. However, no data exist on the predictive value of RVR in HCV carriers with normal ALT values. ...
Lund Helle - - 2011
Hypovolaemic shock is a major course of death in trauma patients. The mortality in patients in profound shock at the time of arrival is extremely high and we wanted to investigate the outcome of patients undergoing laparotomy at the Trauma Care Unit (TCU). Forty-four emergency laparotomies performed at the TCU ...
Mian Asad I - - 2011
Nitric oxide (NO) is involved in normal kidney function and perturbed in acute kidney injury (AKI). We hypothesized that urinary concentration of NO metabolites, nitrite and nitrate, would be lower in children with early AKI presenting to the emergency department (ED), when serum creatinine (SCr) was uninformative. Patients up to ...
Man B L - - 2011
BACKGROUND AND PURPOSE: Concurrent small vessel, intracranial and extracranial large artery disease (SLAD) is common in Asian but its impact on cognitive and functional outcomes is unclear. We aimed to evaluate the clinical, cognitive and functional outcomes in ischemic stroke patients with SLAD. METHODS: Chinese ischemic stroke patients with diffuse ...
Ozawa Eisuke - - 2011
Background/Aims: Serum levels of ferritin and heme oxygenase (HO)-1 are both markers of macrophage activation. We evaluated simple markers for predicting the prognosis of severe acute liver injury in which macrophage activation plays an important role. Methods: Subjects comprised 114 patients with acute liver injury, admitted to the liver unit ...
Hauck Erik F - - 2011
BACKGROUND:: Acute proximal (cervical) internal carotid artery (ICA) occlusion may cause ischemia of an entire hemisphere or no ischemia at all, depending on the presence of intracranial collaterals. OBJECTIVE:: To retrospectively analyze the clinical results for emergent endovascular carotid recanalization in patients with acute proximal (cervical) ICA occlusion. Predictors of ...
López Álvarez J M - - 2011
To describe the epidemiology, clinical manifestations and evolutive characteristics of pediatric patients with severe head injury (SHI). A review was made of the patients admitted to the pediatric intensive care unit (PICU) with SHI between July 1983 and December 2009. Of the 389 patients with head injuries admitted to the ...
Geiger Angie A - - 2011
BACKGROUND: The injury severity score (ISS) assesses anatomical threat to life, but does not correlate with severity perceived by the patient. The purpose of this study was to assess how and why patients assign perceived injury severity. METHODS: One hundred twenty consecutive patients were asked "Would you say your injury ...
Xu Chao - - 2011
The aim of this study was to test the feasibility of vessel size imaging with precise evaluation of apparent diffusion coefficient and cerebral blood volume and to apply this novel technique in acute stroke patients within a pilot group to observe the microvascular responses in acute ischemic tissue. Microvessel density-related ...
Kumar R - - 2011
PURPOSE. To develop a comprehensive Cervical Spine Injury Recovery Prediction Scale (CSIRPS) to predict outcomes for patients with acute subaxial cervical spine injury (CSI). METHODS. 42 men and 18 women (mean age, 41 years) with acute subaxial (C3-C7) CSI and a neurological deficit were evaluated clinically and radiologically after crutch-field ...
Kaiser Meghann L - - 2011
We sought to identify risk factors that might predict acute traumatic injury findings on thoracic computed tomography (TCT) among patients having a normal initial chest radiograph (CR). In this retrospective analysis, Abbreviated Injury Score cutoffs were chosen to correspond with obvious physical examination findings. Multivariate logistic regression analysis was performed ...
Elhmidi Yacine - - 2011
Acute kidney injury (AKI) can occur in up to one third of patients after surgical aortic valve replacement and can be associated with increased mortality. Little data exist, however, about the incidence, predictors, and prognostic implications of AKI after transcatheter aortic valve implantation (TAVI). The aim of this study was ...
Ender Topal A - - 2011
Acute limb ischemia (ALI) is one of the most potentially devastating but treatable diseases, resulting from a sudden obstruction in the arterial flow. The aim of this study was to examine the outcome of thromboembolectomy, and to determine the risk factors associated with limb loss and mortality in ALI. A ...
Rafaelsen S R - - 2011
Aim  This study compared the sensitivity and specificity of contrast-enhanced ultrasound (CEUS) and multidetector-computed tomography (MDCT) in the detection of liver metastases in patients with colorectal cancer. Method  Between September 2004 and December 2008, 271 consecutive patients (146 men and 125 women; median age 68 years, range: 34-91 years) with primary colorectal ...
Ford Andria L AL Washington University, School of Medicine, Department of Neurology, 600 South Euclid Avenue, Campus Box 8111, St. Louis, MO 63110, - - 2011
Statin pretreatment has been associated with improved outcomes in patients with ischemic stroke. Although several mechanisms have been examined in animal models, few have been examined in patients. We hypothesized that patients using statins before stroke onset may have greater reperfusion than patients not using statins. Acute ischemic stroke patients ...
Rosso Charlotte - - 2011
OBJECTIVES: The objective of this work was to investigate the clinical usefulness of the visibility of the transcerebral veins (VTV) in acute ischemic stroke patients at 3T. METHODS: Sixty consecutive carotid artery territory stroke patients were included retrospectively. Two readers categorized the VTV on T2*-weighted sequence at 3T for each ...
De Marchis Emiliano - - 2011
OBJECTIVES: Paradoxical thromboembolism across a patent foramen ovale (PFO) may be involved in the pathogenesis of cryptogenic strokes. We tested the feasibility and the clinical usefulness of an early screening for PFO combining different ultrasound techniques in patients with acute cerebral ischemia of undetermined cause. METHODS: Consecutive patients with acute ...
Lv Li-Quan - - 2011
BACKGROUND:: Dysautonomia after severe traumatic brain injury (TBI) is a clinical syndrome affecting a subgroup of survivors and is characterized by episodes of autonomic dysregulation and muscle overactivity. The purpose of this study was to determine the incidence of dysautonomia after severe TBI in an intensive care unit setting and ...
Ormstad Heidi - - 2011
There is increasing evidence that inflammation plays an important role in the progression of acute ischemic stroke (AIS). The primary aims of this study were to examine the serum levels of 13 cytokines, C-reactive protein (CRP), glucose, and hemoglobin in AIS patients, and their relationship to stroke lateralization, type, and ...
Power Albert - - 2011
Intracranial arterial calcification (IAC) is associated with ischemic stroke in the general population but this relationship has not been examined in hemodialysis patients. We examined the factors associated with IAC and its relationship with acute ischemic stroke in this population. We retrospectively studied 490 head computed tomographic scans from 2225 ...
Lädermann Alexandre - - 2011
BACKGROUND: The majority of rotator cuff lesions involving the supraspinatus occur at or near the level of bone-tendon interface. We present a series of supraspinatus injuries at the musculotendinous junction. METHODS: Between October 2002 and December 2009, we prospectively evaluated all patients presenting with an injury of the supraspinatus at ...
Ho Chao-Hung - - 2011
D-dimer quantitative test is mainly used to rule out the presence of thromboembolic diseases (TEDs). Whether very high D-dimer (100 times above the cutoff point) can exclusively indicate the presence of TED should be known. D-dimer was detected by a quantitative immunoturbidimetric assay. The normal value is 0.2-0.7 mg/L fibrinogen equivalent ...
Kuhlemann Julia - - 2011
Background Periportal edema (PPE) can be seen in different clinical settings, including in patients following trauma. However, the underlying mechanisms and clinical significance in trauma patients still remain unclear. Purpose To determine the incidence of PPE in CT scans of trauma patients and to correlate PPE with trauma severity and ...
van Doormaal Tristan P C - - 2011
BACKGROUND:: A high flow bypass is theoretically more effective than a conventional low flow bypass in preventing strokes in patients with symptomatic carotid artery occlusion (CAO) and a compromised hemodynamic state of the brain. OBJECTIVE:: To study the results of Excimer Laser Assisted Non-occlusive Anastomosis (ELANA) high flow extra-intracranial (EC-IC) ...
Reva V A - - 2011
OBJECTIVE: To analyse management and outcomes of carotid artery (CA) injuries. DESIGN: Retrospective study of the patients in the combat operations in Chechnya (1999-2002) and in peacetime (2003-2009). MATERIALS: A total of 46 patients with missile (27) and stab (19) wounds, who had common and internal CA injury, underwent an ...
Hilz Max J - - 2011
Long-term mortality is increased after mild traumatic brain injury (mTBI). Central cardiovascular-autonomic dysregulation resulting from subtle, trauma-induced brain lesions might contribute to cardiovascular events and fatalities. We investigated whether there is cardiovascular-autonomic dysregulation after mTBI. In 20 mTBI patients (37±13 years, 5-43 months post-injury) and 20 healthy persons (26±9 years), ...
Cook H Terence - - 2011
Segmental sclerosis is frequently seen in IgA nephropathy and is an adverse prognostic indicator in the Oxford classification. Hill and colleagues have studied patients with IgA nephropathy and show that the segmental sclerotic lesions have features that suggest they are due to primary podocyte injury. They confirm the validity of ...
Zhang Liqun - - 2011
BACKGROUND: Transthoracic echocardiography (TTE) is commonly obtained during the evaluation of patients with ischemic stroke or transient ischemic attack (TIA) to detect potential sources of cardiogenic embolism. Specific indications for the tests remain uncertain. METHODS: TTE and transesophageal echocardiography (TEE) use in routine clinical practice were assessed retrospectively in a ...
Zhang Li-San - - 2011
Statins are one of the most common agents prescribed for ischemic stroke patients, but their side effects on the liver are worrisome to both physicians and patients. This study aimed to analyze the features and related factors of the hepatic side effects of statins in patients with ischemic stroke. Four ...
Hussain Manzar - - 2011
Observational, case series. To determine the sensitivity and specificity of clinical judgment as compared to the use of X-ray images in detecting cervical spine injuries in trauma patients presenting in the emergency department of Aga Khan University Hospital, Karachi. Cross-table cervical spine views are important in patients with signs and ...
Gui Junhao - - 2011
Circulating miRNAs (microRNAs) are emerging as promising biomarkers for several pathological conditions, and the aim of this study was to investigate the feasibility of using serum miRNAs as biomarkers for liver pathologies. Real-time qPCR (quantitative PCR)-based TaqMan MicroRNA arrays were first employed to profile miRNAs in serum pools from patients ...
Sun Yirui - - 2011
Objectives:?To estimate the incidence of coagulopathy and disseminated intravascular coagulation (DIC) in patients with traumatic brain injury (TBI) and to investigate its relationship to patient outcome. Design:?A prospective observational study. Measurements and main results.?From January 2007 to June 2009, 242 consecutive adult patients with TBI seen in three independent hospitals ...
Becker Sven - - 2011
Intraoral burning sensations are a common problem in the otolaryngological practice. The aim of this study was to evaluate if laryngopharyngeal reflux can cause intraoral burning sensations by measuring oropharyngeal acid reflux. Patients with recurring intraoral burning sensations underwent oropharyngeal pH monitoring in our outpatient clinic. The pH catheter was ...
Orman Eric S - - 2011
Fluoroquinolone-induced liver injury is rare; no prospective studies of well-characterized case series have been published. We studied patients with fluoroquinolone-induced hepatotoxicity from the Drug-Induced Liver Injury Network (DILIN) to characterize injury patterns, outcomes, and associated features. We identified subjects with fluoroquinolone hepatotoxicity enrolled in the DILIN from September 2004 to ...
van Lammeren Guus W - - 2011
BACKGROUND AND PURPOSE: Carotid endarterectomy (CEA) of stable atherosclerotic plaques is associated with an increased risk for restenosis. Patients with transient ischemic attack and patients with and stroke have relatively unstable atherosclerotic plaques. However, carotid plaques stabilize over time after a cerebrovascular event due to plaque repair after rupture. These ...
Lin Sen - - 2011
Background: There is scant information on characteristics, treatment, functional outcome and case fatality of ischemic stroke with atrial fibrillation (AF) in China. Methods: For this study, first-ever ischemic stroke patients who were admitted within 1 month of stroke onset during the period of March 2002 through December 2008 were included. ...
Fitzek Sabine - - 2011
Background and Purpose: We aimed to validate the usefulness of the Essen Stroke Risk Score (ESRS) to predict stroke recurrence in a hospital-based follow-up study. Methods: We followed up 730 consecutive patients admitted to a neurological stroke unit in Berlin, Germany, with ischemic stroke (IS) or transient ischemic attack (TIA). ...
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