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Kang Yun Pyo - - 2014
To better understand the respiratory lipid phenotypes of asthma, a novel method for lipid profiling of bronchoalveolar lavage fluid (BALF) was developed using HPLC-QTOF-MS with an internal spectral library and high-throughput lipid identifying software. The method was applied to BALF from 38 asthmatic patients (18 patients with non-steroid treated bronchial ...
Sánchez Tania T Immunology and Rheumatology Department, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico DF, Mexico. - - 2014
Our aim was to describe the prevalence of dyslipidaemia, serum lipid behaviour and predictors of serum lipid levels in a cohort of early rheumatoid arthritis (RA) patients. Charts from 146 patients who were lipid-lowering therapy (LLT) free at inclusion and had baseline complete serum fasting lipid profile and ≥1 lipid ...
Koopal C C Department of Vascular Medicine, University Medical Center Utrecht, Utrecht, the - - 2014
BackgroundAPOE genotypes are associated with different plasma lipid levels. People with the APO ɛ2 genotype can develop a disorder called dysbetalipoproteinemia (DBL). A possible predisposing factor for DBL is adiposity. We evaluated whether and to what extent APOE genotype modifies the relation between adiposity and lipids in patients with manifest ...
Kataoka Yu Y Heart Health, South Australian Health & Medical Research Institute, University of Adelaide, Adelaide, South Australia, Australia. Electronic address: - - 2014
Potent statin therapy has been demonstrated to reduce cardiovascular events. Although statins have been considered to stabilize atherosclerotic plaque, this effect has not been well characterized in vivo. We investigated the relation between potent statin therapy and plaque microstructures imaged by frequency-domain optical coherence tomography. Two hundred ninety nonculprit lipid plaques ...
Zhao Shuiping S Department of Cardiology, Second Xiangya Hospital, Central South University, No.139, People Street (M.), Changsha 410011, - - 2014
Despite clear guideline recommendations, there is a paucity of data regarding the prevalence and type of persistent lipid profile abnormalities in patients on stable lipid-lowering therapy in China. This cross-sectional trial included 25,697 patients treated with lipid-lowering agents from 122 centres between April 2012 and October 2012; all underwent clinical ...
Fernández-Nebro A A UGC Reumatología, Instituto de Investigación Biomédica de Málaga (IBIMA), Hospital Regional Universitario de Málaga/Universidad de Málaga, Málaga, - - 2014
Patients with systemic lupus erythematosus (SLE) have increased cardiovascular risk related to lipid changes induced by inflammatory activity, proteinuria and treatments. Our objective was to analyse lipid changes in a cohort of patients with SLE resistant to standard treatments who were treated with rituximab. The study population comprised a retrospective ...
Kircik Leon H - - 2014
Dysfunction of the epidermal barrier is generally considered a precursor of cutaneous inflammation that can directly contribute to the pathogenesis of skin diseases, notably atopic dermatitis (AD). We also know that topical corticosteroids may actually impair the epidermal barrier by interfering with epidermal lipid synthesis. Therefore, it is important to ...
Madhikarmi Nirjala Laxmi NL M.B.Kedia Dental College and Teaching Hospital, Near Custom Office, Birgunj, Parsa, Narayani Zone, Nepal. - - 2014
Background: Iron deficiency anemia is one of the major causes of morbidity and mortality worldwide. Evidences from epidemiological and clinical studies suggest a possible correlation between antioxidant levels and the anemic disease risk. The present work is to investigate antioxidant levels and lipid peroxidation in anemic patients. Methods: A number ...
Unniachan S S School of Public Health, UMDNJ, Piscataway, NJ, - - 2014
Guidelines emphasise the importance of low-density lipoprotein cholesterol (LDL-C) goals for cardiovascular risk reduction. Given the importance of association between high-density lipoprotein (HDL-C) and triglycerides (TG) normal levels and cardiovascular risk, there is an additional need to further evaluate diverse dyslipidaemic populations. A retrospective longitudinal observational study of patients aged ...
Witzel Samantha H SH Department of Paediatrics, Children's Hospital, London Health Science Centre, University of Western Ontario, London, Ontario N6A 5W9, - - 2014
The purpose of this study was to investigate the effect of triglyceride concentration on cystatin C (CysC) measurements. Serum samples collected from 10 nephrology patients, 43 to 78years of age, were air centrifuged to separate aqueous and lipid layers. The lipid layer from each patient was pooled together to create ...
Fayezi S S Infertility and Reproductive Health Research Center, Shahid Beheshti University of Medical Sciences , Tehran , - - 2014
Follicular fluid (FF) samples were obtained from 100 patients referred to the University Hospital. A total of 79 subjects underwent IVF and the remaining 21 underwent ICSI. The levels of apoA-I and total phospholipid were measured using turbidometric and colorimetric phosphorus assays, respectively. Correlation analysis showed a significant inverse association ...
Gandhi Nirav N College of Medical and Dental Sciences, University of Birmingham, Birmingham, - - 2014
Fibrates are used especially in patients with hypertriglyceridaemia, a feature of the metabolic syndrome. Elevated LFTs are often observed in these patients perhaps related to fatty infiltration. We wished to study changes seen in LFTs (GGT, ALT and ALP) following fibrate therapy and then determine associated factors. This was a ...
Mabrouk Hajer H Biochemistry-Toxicology Laboratory, University Hospital of Monastir, Tunisia; Research Laboratory "Vulnerability to Psychotic Disorders LR 05 ES 10", Psychiatry Department, University Hospital of Monastir, Tunisia. Electronic address: - - 2014
This study aimed to investigate the variations of paraoxonase 1 (PON1) activity and lipid profile in patients with schizophrenia and the association of this activity with the sociodemographic, clinical and therapeutical characteristics of this population. Our cross-sectional study included 140 schizophrenic patients and 119 control subjects aged respectively 37.3±10.4 and ...
Yeh Kuo-Wei KW Division of Allergy, Asthma and Rheumatology, Department of Pediatrics, Chang Gung Memorial Hospital at Linkou, and Chang Gung University, Taoyuan, - - 2014
Dyslipidemia with higher inflammatory states, disease activity, and longer disease duration in juvenile idiopathic arthritis (JIA) patients seemed to increase the risks of atherosclerosis. Tumor necrosis factor- α (TNF-α) receptor blocking agent etanercept has been proven to be effective in JIA. However, data about the correlation of anti-inflammatory treatment on ...
Li J J Department of Cardiology, Tongji Hospital, Tongji University, Shanghai, China - - 2014
This study aimed to investigate the relationship between the cholesterol ester transfer protein (CETP) gene TaqIB polymorphism and the lipid-lowering effect of atorvastatin in patients with coronary atherosclerotic heart disease. Two hundred eighty-eight patients were divided into a control group, an acute coronary syndrome (ACS) group, and a stable coronary ...
Manka Paul P Department of Gastroenterology and Hepatology, University Hospital, University Duisburg-Essen, Essen, - - 2014
Emerging data links different aspects of lipid metabolism to liver regeneration. In patients with acute liver failure (ALF), low levels of lipids may correlate with disease severity. Thus, we determined whether there is an etiology-specific link between lipid levels in patients suffering from ALF and aimed to investigate an effect ...
Kosiba Waldemar - - 2014
To assess the correlation of the level of cholesterol fractions and balance in two groups of patients with well and poorly controlled hypertension. The study included 106 patients: 41 males and 65 females with diagnosed arterial hypertension without concomitant diseases which could affect the balance system. The average age of ...
van Smeden J - - 2013
Netherton Syndrome (NTS) is a rare genetic skin disease caused by mutations in the serine protease inhibitor Kazal-type 5 gene, which encodes the lympho-epithelial Kazal-type-related inhibitor. NTS patients have a profound impaired skin barrier function. Because SC lipids play a crucial role in the skin barrier function, we investigated the ...
Lei Chunyan - - 2013
Lipid levels may be involved in intracerebral hemorrhage (ICH) etiology, which suggested that lipid levels may be associated with the etiology of microbleeds (MBs) in patients with ICH. To explore this, we examined the association between lipid levels and MBs in different cerebral regions in patients with ICH. Patients admitted ...
van de Woestijne Anton P - - 2013
Several single nucleotide polymorphisms (SNPs) are associated with both plasma low-density lipoprotein cholesterol (LDL-c) level and coronary artery disease in the general population. It is unclear whether these associations also apply to patients with vascular disease, and whether the associations are independent of lipid-lowering therapy. SNPs associated with plasma LDL-c ...
Chen Shili - - 2013
In this study, an ultra fast LC/IT-TOF MS (UFLC/IT-TOF MS)-based serum lipidomics method was employed to characterize the serum lipid profile of patients with chronic hepatitis B, cirrhosis, and hepatocellular carcinoma (HCC). After data collection and processing, 96 lipids including lysophosphatidylcholines, phosphatidylcholines, sphingomyelins, triacylglycerides, and cholesterol esters were identified and ...
Mutlu Serkan - - 2013
The purpose of this present study is to investigate the levels of oxidative stress parameters in patients with subclinical hypothyroidism (SH) and the effects of levothyroxine (LT4) replacement therapy on these parameters and lipid profile. At the beginning of the study blood samples were collected from the patients in order ...
Ferrières Jean - - 2013
Objectives: Despite statin use, many patients with cardiovascular disease (CVD) are not achieving treatment goals. An international observational study was performed to estimate the prevalence of residual lipid abnormalities in statin-treated patients with CVD to assess whether lipid management requires improvement. Methods: Fasting plasma concentrations of low-density lipoprotein cholesterol (LDL-C), ...
Zahran Asmaa M - - 2013
We studied the level of lipid peroxide, nitric oxide (NO), trace elements (TEs), and microparticles (MPs) in Gaucher disease (GD) before and after 1 year of enzyme replacement therapy (ERT). A total of 15 children with GD and 15 healthy controls were enrolled in this study. Serum level of lipid ...
Akoglu Hadim - - 2013
Background/Aims: We aimed to evaluate the impact of low- or high-flux haemodialysis (HD) and online haemodiafiltration (OL-HDF) on inflammation and the lipid profile in HD patients. Methods: 50 HD patients were assigned to two groups for HD with low-flux (n = 25) or high-flux (n = 25) polysulphone dialysers for ...
Akkara Veetil Bharath Manu BM Division of Rheumatology and Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota 55905, - - 2013
Rheumatoid arthritis (RA) is associated with an increased risk of cardiovascular disease and mortality. Lipid-lowering therapy is reportedly underused in patients with RA. Longitudinal cohort studies comparing use of lipid-lowering medications in patients with RA versus the general population are lacking. Cardiovascular risk factors, lipid measures, and use of lipid-lowering ...
Nillawar Anup N AN Associate Professor, Department of Biochemistry, SBKS Medical College , Vadodara, Gujarat, India - - 2013
COPD is a major public health problem. More than 50 % of the patients of COPD die because of some cardiovascular event. Traditionally, the risk of CVD is assessed by the presence of dyslipidaemia. Recently, HS-CRP has emerged as a novel risk factor for the CVD assessment. In this study, ...
Lajoinie A - - 2013
The importance of the lipid matrix of stratum corneum (SC) in epidermal barrier function is well documented. Intravenous lipid emulsions (ILE) provide essential fatty acids (EFAs), main components of the SC lipid matrix. The objective of this study was to investigate the influence of ILE upon SC barrier function. The ...
Kato Koji - - 2013
BACKGROUND: -Chronic kidney disease (CKD) promotes the development of atherosclerosis and increases the risk of cardiovascular disease. The aim of the present study was to compare the coronary plaque characteristics of patients with and without CKD using optical coherence tomography (OCT). METHODS AND RESULTS: -We identified 463 non-culprit plaques from ...
Hsu Tun-Ying - - 2013
BACKGROUND: Although LDL-C is the primary lipid target for coronary heart disease (CHD) risk reduction, HDL-C and triglycerides (TG) have also emerged as CHD risk factors. OBJECTIVE: The objective of this study was to evaluate goal/normal lipid level attainment after lipid-modifying therapy (LMT) in an ethnically diverse sample of patients ...
Gabe Simon M - - 2013
PURPOSE OF REVIEW: Abnormalities of liver function tests are common in patients with intestinal failure receiving parenteral nutrition. Lipid emulsions have been implicated in the development of hepatobiliary disease in patients receiving parenteral nutrition. RECENT FINDINGS: Lipid emulsions with reduced polyunsaturated fatty acids and specific ω6 : ω3 fatty acid ratios have ...
Maehlen Marthe T - - 2013
Apolipoprotein E (APOE) genotypes are associated with cardiovascular disease (CVD) and lipid levels. In rheumatoid arthritis (RA), an association has been found with disease activity. We examined the associations between APOE genotypes and disease susceptibility and markers of disease severity in RA, including radiographic joint damage, inflammatory markers, lipid levels ...
Phukan Jyoti Prakash - - 2013
Alcoholic cirrhosis is often associated with impaired lipid metabolism. However, there are only a few studies regarding lipid profile in alcoholic cirrhosis that have been undertaken in India. The aim of the study is to assess the degree of alteration of serum lipid profile in alcoholic cirrhotic patients and also ...
Gregório Michele L - - 2013
The pathogenesis of Parkinson's disease (PD) seems to involve genetic susceptibility to neurodegeneration. APOE gene has been considered a risk factor for PD. This study aimed to evaluate the association of APOE polymorphism with PD and its influence on lipid profile. We studied 232 PD patients (PD) and 169 individuals ...
Kundu Ria - - 2013
We describe the management of a young patient who had experienced a cocaine overdose. The patient presented with altered mental status and seizures and subsequently developed a wide complex arrhythmia with a rare alternating bundle branch block pattern. Intravenous lipid emulsion was administered following initial resuscitation and endotracheal intubation, because ...
Colquhoun David D University of Queensland, Brisbane, - - 2013
Few studies have assessed the prevalence of mixed dyslipidemia (MD) and the effectiveness of lipid-modifying therapy (LMT) for the treatment of abnormal levels of low-density lipoprotein cholesterol (LDL-C), triglycerides (TG) and high-density lipoprotein cholesterol (HDL-C) in Australian clinical practice. To estimate the prevalence of MD in Australian patients undergoing LMT. ...
Rollefstad Silvia - - 2012
OBJECTIVES: To perform cardiovascular risk stratification in patients with inflammatory joint diseases (IJD) and treat to lipid targets according to recommendations. METHODS: We initiated a preventive cardio-rheuma clinic based on the unmet need of adequate cardiovascular prevention in IJD patients. A full cardiovascular risk stratification was performed at the first ...
Akinlolu A - - 2012
This study investigated Lipid peroxidation status in twenty Nigerians; five (5) healthy subjects and 15 (fifteen) Haematological cancer patients; 5 affected with Chronic Myeloid leukaemia (CML), 5 (five) with Non-Hodgkin's Lymphoma and 5 (five) with Multiple Myeloma. Consents were sought and received from all participants used in the study. 10 ...
Ahmadi Farokhlagha - - 2012
Elevated levels of intact parathyroid hormone (iPTH) may play an important role in the pathogenesis of the dyslipidemia in hemodialysis (HD) patients, but the underlying mechanisms are not clearly defined. In this cross-sectional study, we examined the effects of iPTH on dyslipidemia among HD patients by analyzing the data of ...
Cabarkapa Velibor - - 2012
Cardiovascular morbidity and mortality are markedly increased in chronic renal failure (CRF). The aim of this study was to evaluate lipid parameters and bioindices in patients with different stages of CRF. In 46 hemodialysed (HD), 50 CRF patients with II, III and IV stage of CRF (non-HD) and 48 control ...
Janssens Michelle M Department of Drug Delivery Technology, Leiden/Amsterdam Center for Drug Research, Leiden University, Leiden, The - - 2012
A hallmark of atopic eczema (AE) is skin barrier dysfunction. Lipids in the stratum corneum (SC), primarily ceramides, fatty acids, and cholesterol, are crucial for the barrier function, but their role in relation to AE is indistinct. Filaggrin is an epithelial barrier protein with a central role in the pathogenesis ...
Curtis Jeffrey R - - 2012
To investigate the frequency of lipid testing in clinical practice and to explore the relationship between rheumatoid arthritis (RA), dyslipidemia, and other cardiovascular (CV) risk factors with RA treatment. Patients in this retrospective database study were ages ≥18 years and had ≥2 physician diagnoses for RA or osteoarthritis (OA; comparator ...
Taniguchi Eitaro E Division of Gastroenterology, Department of Medicine Department of Digestive Disease Information and Research, Kurume University School of Medicine, Kurume, - - 2013
  Cognitive dysfunction (CD) is frequently observed in cirrhotic patients. However, the biochemical profiles associated with CD remain unclear. We investigated the biochemical profiles associated with the incidence of CD in cirrhotic patients by using multivariate analyses, including a decision-tree algorithm.   In this study, 27 viral cirrhotic patients were ...
Miedema Irene - - 2012
Evaluation of: Rocco A, Sykora M, Ringleb P, Diedler J. Impact of statin use and lipid profile on symptomatic intracerebral haemorrhage, outcome and mortality after intravenous thrombolysis in acute stroke. Cerebrovasc. Dis. 33(4), 362-368 (2012). Statins are widely used in the primary and secondary prevention of cardiovascular disease and prevent ...
Piskinpasa Serhan - - 2012
Secondary amyloidosis is the most frequent form of the systemic amyloidosis around the world. Data on frequency and nature of dyslipidemia in patients with secondary amyloidosis are not conclusive. We evaluated the lipid abnormalities and their association with clinical and laboratory characteristics of the patients with secondary amyloidosis. The reports ...
Weiler Stefan - - 2012
The pharmacokinetics of lipid-bound and liberated amphotericin B (AMB) was assessed in 11 critically ill patients with cholestatic liver disease (CSLD) and in 9 subjects with normal liver function treated with AMB colloidal dispersion (ABCD). Exposure to lipid-bound AMB was higher in patients with CSLD. Levels of liberated AMB were ...
Rahalkar Amit R - - 2012
BACKGROUND: The loss of patent protection for proprietary statins offers affordability advantages to payers, but some clinicians still question the efficacy of generic formulations in real-world clinical applications. METHODS: In this retrospective cohort study, we examined the effects of generic atorvastatin substitution on relevant biochemical parameters in 85 dyslipidemic patients ...
Giera Martin - - 2012
Human synovial fluid (SF) provides nutrition and lubrication to the articular cartilage. Particularly in arthritic diseases, SF is extensively accumulating in the synovial junction. During the last decade lipids have attracted considerable attention as their role in the development and resolution of diseases became increasingly recognized. Here, we describe a ...
Kato Koji - - 2012
Patients with acute coronary syndrome (ACS) have a higher incidence of recurrent ischemic events. The aim of this study was to compare the plaque characteristics of nonculprit lesions between ACS and non-ACS patients using optical coherence tomography (OCT) imaging. Patients who had 3-vessel OCT imaging were selected from the Massachusetts ...
Raterman Hennie G - - 2012
OBJECTIVE: An atherogenic lipid profile is an established risk factor for cardiovascular (CV) diseases. Interestingly, high inflammatory states as present in rheumatoid arthritis (RA) are associated with unfavourable lipid profile. Data about effects of novel immunomodulating agents as rituximab (RTX) on lipid profile are limited. Therefore, changes in lipids in ...
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