Search Results
Results 501 - 550 of 2242
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Sohtao─člu Melis - - 2010
OBJECTIVE: Impulse control disorders (ICDs) are mainly triggered by dopaminergic therapy in Parkinson's disease (PD). Previously, we failed to identify a relationship between the types of dopaminergic therapy and occurrence of ICDs in 33 PD patients. In this study, we aim to evaluate the outcome of ICD behaviors in the ...
Mann Rena K - - 2010
OBJECTIVE: Examine the level of intra- and inter-limb coherency in non-dyskinetic and dyskinetic patients with Parkinson's disease (PD). PATIENTS & METHODS: Using a magnetic tracking system, whole-body 3D movements were assessed in 10 dyskinetic patients with clear monophasic peak-dose levodopa-induced dyskinesia (LID), in 10 non-dyskinetic patients and in 10 control ...
Kenangil Gulay - - 2010
OBJECTIVE: The aims of this study were to assess frontal dysfunction in Turkish patients with idiopathic Parkinson disease (PD) by using frontal assessment battery (FAB), and to determine the relationship among FAB scores and education, Mini-Mental State Examination (MMSE), and severity of the disease. BACKGROUND: Cognitive impairment in patients with ...
van Horne Craig - - 2010
Parkinson's disease (PD) is a neurodegenerative disease causing hypokinetic dysarthria, associated with "blurred" or underarticulated speech, imprecise consonants, and, sometimes, irregular syllable trains. Within the past decade, deep brain stimulation (DBS) of the subthalamic nucleus (STN) has provided substantial benefit to PD patients. DBS treatment has largely been directed toward ...
Hurtuk Michael G - - 2010
BACKGROUND: Most pancreaticoduodenectomies (PDs) are performed to treat periampullary malignancies (PMs). Final pathologic analysis on these specimens does not always contain PMs. Our aim was to classify diseases that preoperatively mimic PMs. METHODS: A prospective database of PDs performed at a single institution was reviewed. Clinicopathologic data on patients without ...
McNamara Patrick - - 2010
We examined potential neurocognitive mechanisms of indirect speech in support of face management in 28 patients with Parkinson's disease (PD) and 32 elderly controls with chronic disease. In experiment 1, we demonstrated automatic activation of indirect meanings of particularized implicatures in controls but not in PD patients. Failure to automatically ...
Haag-Weber Marianne - - 2010
BACKGROUND: Residual renal function (RRF) impacts outcome of peritoneal dialysis (PD) patients. Some PD fluids contain glucose degradation products (GDPs) which have been shown to affect cell systems and tissues. They may also act as precursors of advanced glycosylation endproducts (AGEs) both locally and systemically, potentially inflicting damage to the ...
Foster Paul S - - 2010
OBJECTIVE: This investigation sought to examine the potential moderating influence of heightened anxiety on working memory in Parkinson disease (PD) patients. Further, we wanted to determine whether this moderating influence of anxiety differentially affects PD patients with left hemibody (LBH) versus right hemibody (RHB) onset of motor symptoms. BACKGROUND: Research ...
Bertoni John M - - 2010
OBJECTIVE: To evaluate the possible association of Parkinson disease (PD) and melanoma in North America. DESIGN, SETTING, AND PATIENTS: Thirty-one centers enrolled patients with idiopathic PD. At visit 1, a neurologist obtained a medical history. At visit 2, a dermatologist recorded melanoma risk factors, performed a whole-body examination, and performed ...
Godau Jana - - 2010
OBJECTIVE: Insulin-like growth factor 1 (IGF-1) provides protection against loss of dopaminergic neurons in animal models of Parkinson's disease (PD). The aim of this study was to measure serum IGF-1 in patients with PD and assess its correlation with the clinical presentation. METHODS: Serum IGF-1 and growth hormone (GH) levels ...
Giardino Nicholas D - - 2010
The prevalence of panic disorder (PD) in patients with chronic obstructive pulmonary disease (COPD) is significantly higher than that in the general population. Comorbid anxiety disorders in COPD are associated with a number of worse outcomes, however little is known about the mechanisms by which PD affects patients with COPD. ...
Pons Roser - - 2010
To assess the spectrum of movement disorders, we reviewed video recordings and charts of 57 patients with Glut-1 deficiency. Eighty-nine percent of patients with Glut-1 deficiency syndrome had a disturbance of gait. The most frequent gait abnormalities were ataxic-spastic and ataxic. Action limb dystonia was observed in 86% of cases ...
Friedrich Constanze - - 2010
Autonomic dysfunction has been frequently demonstrated in patients with extrapyramidal diseases by cardiovascular autonomic testing. In addition to classical testing, we applied the more detailed baroreflex and spectral analysis on three traditional cardiovascular tests in this study to get additional information on autonomic outflow. We recorded continuously blood pressure, electrocardiogram, ...
Zibetti M - - 2010
OBJECTIVE: To assess whether the presence of probable REM sleep behaviour disorder (pRBD) influences the long-term outcome of Parkinson's Disease (PD) patients undergoing Subthalamic Nucleus Deep Brain Stimulation (STN-DBS). BACKGROUND: RBD is a parasomnia characterized by loss of muscular atonia and complex motor behaviours during REM sleep, frequently reported in ...
Nurmi Jouni - - 2010
Peritoneal dialysis (PD) is probably underused because of fears concerning the body image of patients. For the purposes of providing exact information for patients when choosing between PD and hemodialysis, we studied the extent of increase in waist circumference by infusing dialysate. The abdominal circumference of 44 PD patients was ...
Yamashita Fumitada - - 2010
PURPOSE: To compare pupillary autonomic dysfunction in multiple system atrophy (MSA) and Parkinson's disease (PD). METHODS: We administered eye-drop tests to 40 MSA patients, 40 PD patients with similar disease duration, and 20 age-matched healthy controls. Pupillary supersensitivity to a parasympathomimetic agent (0.05% pilocarpine hydrochloride) and to a sympathomimetic agent ...
Pugnetti Luigi - - 2010
Electroencephalogram (EEG) reactivity to eyes opening and 12-Hz photic stimulation was investigated in 14 healthy elderly subjects, 21 parkinsonian patients (PD), 7 demented parkinsonian patients (PDD), and 10 patients with Lewy body dementia (LBD) using global field synchronization (GFS). During eyes closed Theta GFS was increased in Parkinson's disease and ...
Perez Lloret Santiago - - 2010
There is growing interest in developing inexpensive and objective motor fluctuation evaluation methods for Parkinson's disease (PD). We aim to compare activity level in the off state, on state, and dyskinetic periods as evaluated either by a physician during a levodopa challenge or by a 72-hr on-off diary self-evaluation in ...
Berent Robert - - 2011
Periodontal inflammation has been implicated in atherosclerosis and coronary heart disease (CHD). Coronary angiography (CA) is used in the assessment of CHD; only a few studies have evaluated periodontal disease (PD) and angiographic measures of coronary atherosclerosis. The aim of this study was to investigate the association between CHD and ...
Felicio Andre C - - 2010
Despite its relatively high prevalence Parkinson's Disease (PD) is still misdiagnosed in approximately 25% of cases. In this study our aim was to evaluate patients with Clinically Unclear Parkinsonian Syndromes (CUPS) submitted to brain SPECT imaging using the technetium-99m labeled Dopamine Transporter (DAT) tracer TRODAT-1. We recruited 15 subjects with ...
G?mez-Esteban Juan Carlos - - 2010
INTRODUCTION: The presence of asymmetry in symptoms and clinical signs favours the diagnosis of Parkinson's disease (PD). The aim of this study is to analyse this symptom asymmetry as a function of different variables and compare it with other parkinsonisms. MATERIALS AND METHODS: 201 Patients with PD were studied. The ...
Santangelo Gabriella - - 2010
The purpose of this study is to compare the neuropsychological profile of patients affected by parkinsonism and vascular lesions to that in patients with PD alone (PD) and to evaluate whether the brain vascular lesion load is associated with neuropsychological variables. Thirty-six nondemented patients with parkinsonism were divided into 3 ...
Snijders Anke H - - 2010
Freezing of gait (FOG) is a common and disabling feature of Parkinson's disease (PD). Detailed pathophysiological studies are hampered by the fact that FOG episodes are difficult to elicit in a gait laboratory. We evaluated whether the need to avoid sudden obstacles on a treadmill can provoke FOG. We included ...
Okamura Nobuyuki - - 2010
PET provides a noninvasive means to evaluate the functional integrity of the presynaptic monoaminergic system in the living human brain. METHODS: In this study, a novel (18)F-labeled tetrabenazine derivative, (18)F-(+)fluoropropyldihydrotetrabenazine ((18)F-AV-133), was used for the noninvasive assessment of the vesicular monoamine transporters type 2 (VMAT2) in 17 Parkinson disease (PD) ...
Felicio Andre C - - 2010
OBJECTIVES: To evaluate patients with "clinically established" psychogenic parkinsonism (PsyP) using single-photon emission computer tomography (SPECT) with the technetium-99m labeled tracer TRODAT-1, a dopamine transporter (DAT) ligand, and investigate whether these patients have an underlying degenerative parkinsonism. PATIENTS AND METHODS: Five patients with PsyP were assessed using demographic data, standard ...
Miwa Hideto - - 2010
Although hiccups may be a non-motor symptom of Parkinson's disease (PD), they have attracted little research attention to date. To investigate the frequency of occurrence of hiccups in PD. The presence of hiccups was evaluated using face-to-face interviews in 90 PD patients and 100 age-matched controls. Eighteen (20%) of the ...
Alphs Hannah H - - 2010
Penile vascular abnormalities occur in a high proportion of patients with Peyronie's disease (PD). Penile duplex ultrasonography (PDU) and dynamic infusion cavernosometry and cavernosography (DICC) are tools that can be used to help tailor individualized treatment for patients undergoing surgical intervention for their PD. However, precisely which parameters can be ...
Balsa Alejandro - - 2010
To investigate the accuracy of composite scores in classifying RA patients who are in remission using the absence of inflammatory activity detected by ultrasound (US) as a gold standard. Ninety-seven RA patients who were classified by their rheumatologists as being in remission were studied. Disease activity was assessed by the ...
Pavese Nicola N MRC Clinical Science Centre and Division of Neuroscience and Mental Health, Imperial College, London, UK. - - 2010
PET studies in parkin-linked parkinsonism have generally been performed to assess striatal dopaminergic dysfunction and very little is known about the involvement of other monoaminergic structures in these patients. Measurements of (18)F-dopa uptake into serotonergic and noradrenergic structures provide an indication of the functional integrity of these nerve terminals. We ...
Ramjit Amit L - - 2010
Autonomic symptomatology is prevalent in Parkinson's disease (PD) and impacts quality of life, yet little data exist on the presentation of autonomic dysregulation. This study measures orthostasis, constipation, and anosmia in 58 PD patients and 51 age-matched controls enrolled in the University of Florida's Movement Disorders Center. Patients had their ...
Zoccolella S - - 2010
Hyperhomocysteinemia has been associated with cognitive dysfunction and dementia. The incidence of dementia in Parkinson's Disease (PD) patients is higher than in the general population and plasma Homocysteine concentrations are increased in L-dopa treated PD patients. We evaluated the possible correlations between L-Dopa related hyperhomocysteinemia and cognitive dysfunction in PD. ...
Gil Lucia M - - 2010
Tremor in Parkinson's disease (PD) is a fundamental feature used in the determination of disease onset and progression. Traditionally, tremor has been evaluated using frequency domain analysis. However, in many cases, this analysis did not show significant differences comparing healthy elders and individuals with PD. Given its complex nature, recently ...
Raggi Alberto - - 2010
To describe functioning and disability of patients with Parkinson's Disease (PD) according to the model endorsed by the International Classification of Functioning Disability and Health (ICF). Adult PD patients were consecutively enrolled. The ICF checklist and the WHO Disability Assessment Schedule II (WHO-DAS II) were administered in individual sessions. Hoehn ...
Lyoo Chul Hyoung - - 2010
Half of Parkinson's disease (PD) patients with mild cognitive impairment (MCI) develop dementia. We studied topographic distribution of cerebral hypometabolism in PD with different types of MCI. This study included 61 nondemented PD patients and 14 age-matched controls. PD patients were grouped into normal cognition (PD-NC, n = 20), single ...
Gaenslen Alexandra - - 2010
The accuracy of the clinical diagnosis of Parkinson's disease (PD) is still limited. Especially in the early stages, when cardinal symptoms are not conclusive, diagnosis can be delayed as structural neuroimaging methods such as CCT or MRI do not provide characteristic features that allow the diagnosis of this chronic neurodegenerative ...
Martínez-Corral Mercè - - 2010
Apathy is a frequent feature of Parkinson's disease (PD), usually related with executive dysfunction. However, in a subgroup of PD patients apathy may represent the only or predominant neuropsychiatric feature. To understand the mechanisms underlying apathy in PD, we investigated emotional processing in PD patients with and without apathy and ...
Zoccolella S - - 2010
BACKGROUND: Homocysteine (Hcy) exerts multiple neurotoxic mechanisms that have been linked to the pathogenesis of neurodegenerative disorders. Several studies observed elevated plasma Hcy levels in Parkinson's Disease (PD) patients treated with L-dopa, compared to healthy controls and to patients with other neurodegenerative disorders. OBJECTIVE: We performed an overview of published ...
Ebert D - - 2010
In 18 healthy age- and sex- matched controls and 13 patients with Wilsons disease (18-50 years) under continuous copper chelating therapy sinusoidal forearm movements of a given target rates (target rates: 0.2, 0.3, 0.4, 0.5, 0.6 Hz) as well as breathing movements were recorded by means of a goniometer and ...
Abe Kazuo - - 2010
Objectives. Abnormalities of posture represent one of the main features of Parkinson's disease (PD). Among them, camptocormia has been considered as rare in PD. We investigated frequency and clinical features of camptocormia in PD patients. Methods. 153 PD patients (mean 68.5 ± 10.7 years old, duration 5.9 ± 2.4 years) ...
Baú Anne-Rose - - 2010
Objectives: To establish the frequency of auto-antibodies anti-HSP 70 using ELISA and Western Blot (WB) methods and to compare the results of each method among patients with the Ménière's Disease (MD) and internal ear diseases (IED) who do not fulfill criteria for MD. Sensibility, specificity and predictive values of anti-HSP70 ...
Mitoma Hiroshi - - 2010
In the advanced stage of Parkinson's disease (PD), motor fluctuation is a frequent and a disabling problem. Despite its importance, motor fluctuation has received little scientific analysis probably due to limitation in objective assessment. Here, we focused on gait disorders to estimate motor fluctuation in daily activities. Using a new ...
Costa Alberto - - 2010
Alexithymia, a reduction in the tendency to think about emotions, together with a difficulty in identifying and describing feelings, has been characterized as a personality trait, but may be secondary to other pathological conditions. The authors aimed at investigating alexithymia in Parkinson's disease (PD). Seventy PD patients and 70 control ...
Zarzur Ana Paula - - 2010
Parkinson's disease (PD) involves a progressive depletion of dopamine in the basal ganglia leading to motor alterations. Oral communication impairment occurs in 75% to 90% of patients and has been poorly studied. to asses laryngeal electromyography (LEMG) patterns and correlate them to vocal analysis in patients with Parkinson's disease. This ...
Koh Seong-Beom - - 2010
Most cardinal motor signs in Parkinson's disease (PD) are more pronounced on one side than on the other. Unusually, one type of cardinal motor sign is found on one side while other motor signs are more pronounced on the contralateral side, the so-called dissociation of motor signs. The aims of ...
Stockner Heike - - 2010
Essential tremor (ET) is the most common adult movement disorder. Especially in early stages the clinical differentiation between essential and Parkinsonian tremor may be a diagnostic challenge. Recent studies have consistently found hyperechogenic alterations in the area of the substantia nigra (SN) in patients with Parkinson's disease (PD) using transcranial ...
Taravari A - - 2010
The aim of this paper is to analyze the results of correlation of clinical symptoms and their characteristics with the results of neurophysiologic, neuropsycologic investigations and short genetic analyses in patients with Idiopathic Parkinson's disease (IPD). MATERIAL AND METHODS: The paper is a prospective and retrospective study of 15 IPD ...
Rissanen Saara M - - 2010
In this paper, we examine the potential of electromyographic (EMG) and acceleration measurements in discriminating patients with Parkinson's disease (PD) from healthy persons. Two types of muscle contractions are examined: static contractions of biceps brachii muscles and elbow extension movements. Twelve features are extracted from static and ten features from ...
Morishita Takashi - - 2010
Differentiating between Parkinson disease (PD) and idiopathic normal pressure hydrocephalus (INPH) can be challenging for the practicing clinician. Patients with undiagnosed PD but with incidental ventriculomegaly run the risk of being subjected to unnecessary shunt surgery. Taking a family history of PD and establishing the presence of motor symptoms (tremor, ...
Lebouvier Thibaud - - 2010
The presence of Lewy bodies and Lewy neurites (LN) has been demonstrated in the enteric nervous system (ENS) of Parkinson's disease (PD) patients. The aims of the present research were to use routine colonoscopy biopsies (1) to analyze, in depth, enteric pathology throughout the colonic submucosal plexus (SMP), and (2) ...
Ahmed Shiek S S J - - 2010
Parkinson's disease (PD) is the most common neurodegenerative disorder. The diagnosis of PD is challenging and currently none of the biochemical tests have proven to help in diagnosis. Serum metallomic analysis may suggest the possibility of diagnosis of PD. The metallomic analysis was targeted on 31 elements obtained from 42 ...
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