Search Results
Results 1 - 50 of 1151
1 2 3 4 5 6 7 8 9 10 >
Nardis Chiara - - 2012
Psoriasis vulgaris (PsV) and psoriatic arthritis (PSA) are inter-related heritable inflammatory skin diseases. Psoriatic lesions develop as a result of abnormal immune responses, hyperproliferation and altered differentiation of keratinocytes, and a notable subset of psoriatic patients develops PsA, characterized by joints inflammation. Recently, biological drugs were introduced to treat these ...
Mabvuure Nigel - - 2012
A best evidence topic in cardiac surgery was written according to a structured protocol. The question addressed was 'In patients with carcinoid syndrome undergoing valve replacement, will a biological valve have acceptable durability?' Altogether, more than 130 papers were found using the reported search, of which 17 represented the best ...
Kuroda Takeshi - - 2012
OBJECTIVE: Reactive amyloid A (AA) amyloidosis is a serious and life-threatening systemic complication of rheumatoid arthritis (RA). We evaluated the safety of therapy with anti-tumor necrosis factor and antiinterleukin 6 biologic agents in RA patients with reactive AA amyloidosis, together with prognosis and hemodialysis (HD)-free survival, in comparison with patients ...
Takamura Akito - - 2012
OBJECTIVE: We investigated associations between treatment with methotrexate (MTX) or biological disease-modifying antirheumatic drugs (DMARDs) and elevation of serum Krebs von den Lungen-6 (KL-6) levels in Japanese patients with rheumatoid arthritis (RA). METHODS: Using a standardized form, data were collected retrospectively from medical records and analyzed descriptively. RESULTS: Of a ...
Tong Haixia - - 2012
Background/Aims: To investigate the immunophenotype of 46 Chinese patients with T-lineage acute lymphoblastic leukemia (T-ALL) and its association with biological and clinical features. Methods: 46 patients with T-ALL were immunophenotyped by flow cytometry, and 30 cases were also subjected to karyotype analysis by R-banding technology. The clinical and biological characteristics ...
Dewedar Ahmed M - - 2012
Rheumatoid arthritis (RA) is a chronic, systemic inflammatory disorder affecting synovial joints and many other organs. Most patients seen in clinical settings have a progressive chronic disease, with radiographic damage, frequent work disability, incremental functional declines and increased mortality rates. The introduction of the biological drugs in treatment of RA ...
Greenberg Jeffrey D - - 2012
To compare the effectiveness of anti-tumour necrosis factor (TNF) agents in biologically naive and 'switched' rheumatoid arthritis (RA) patients. RA patients enrolled in the CORRONA registry newly prescribed adalimumab (n=874), etanercept (n=640), or infliximab (n=728) were stratified based on previous anti-TNF use. Clinical effectiveness at 6, 12 and 24 months ...
Harigai Masayoshi - - 2012
We implemented a retrospective study to explore discontinuation of therapy with adalimumab (ADA) without exacerbation in rheumatoid arthritis (RA) patients who had achieved low disease activity (LDA) with the biological agent. We enrolled 46 RA patients who had completed open extension of a double-blind, placebo-controlled trial of ADA monotherapy in ...
Chiu H Y - - 2012
HLA-Cw*06 has a strong influence on the clinical features and the susceptibility to psoriasis in different ethnicities. It is also used as a biomarker to predict the therapeutic efficacy of biologics, with inconsistent results. Additionally, most Asian patients with psoriasis do not carry HLA-Cw*06. To determine additional HLA alleles which ...
Nkoghe Dieudonné - - 2012
Chikungunya virus (CHIKV) has caused multiple outbreaks in tropical and temperate areas worldwide, but the clinical and biological features of this disease are poorly described, particularly in Africa. We report a prospective study of clinical and biological features during an outbreak that occurred in Franceville, Gabon in 2010. We collected, ...
Zhang Jie J University of Alabama at Birmingham, 35294, - - 2011
To examine the threshold in disease activity associated with switching biologic treatment regimens in rheumatoid arthritis (RA) patients in real-world clinical practice. Using data from a prospective observational North American cohort of RA patients through December 30, 2009, patients who initiated a new anti-tumor necrosis factor α (anti-TNFα) agent with ...
Hallert Eva - - 2011
Objective. To explore the incidence of disability pension (DP) due to RA as an estimation of permanent work disability before and after introduction of biological drugs.Methods. The annual incidence of DP was derived from the Swedish National Social Insurance Register and rates of DP due to RA were compared with ...
Bafadhel Mona M Institute for Lung Health, University of Leicester, Leicester, United - - 2011
Exacerbations of chronic obstructive pulmonary disease (COPD) are heterogeneous with respect to inflammation and etiology. Investigate biomarker expression in COPD exacerbations to identify biologic clusters and determine biomarkers that recognize clinical COPD exacerbation phenotypes, namely those associated with bacteria, viruses, or eosinophilic airway inflammation. Patients with COPD were observed for ...
Hoving Eelco W - - 2011
The value of intraoperative neurophysiological monitoring (IONM) with surgical detethering in dysraphic patients has been questioned. A retrospective analysis of our series of 65 patients is presented with special focus on technical set-up and outcome. All patients were diagnosed with a tethered cord (TC) due to spinal dysraphism. A high-risk ...
Sahin Ozlem - - 2011
The pathogenesis of widespread pain and increased tenderness in Fibromyalgia (FM) are still unknown. Recently, the role of central nervous system hyperexcitability is emphasized in pathogenesis of FM. The central sensitization was demonstrated with decrease in nociceptive flexion reflex (NFR) threshold in patients with FM. The NFR and cutaneous silent ...
Feng Shang-Wen - - 2011
We retrospectively reviewed plain radiographs from patients with four different diseases that can cause vertebral collapse: osteoporotic vertebral collapse, spinal infection, spinal metastasis, and multiple myeloma. The objective of the study was to find the percentages of intravertebral vacuum phenomena and vertebral collapse rates in the four groups. The vacuum ...
Mutchnick Ian S - - 2011
Object The current standard of care for symptomatic chronic spondylolysis (SP) is a one-level posterior spinal fusion for defects at L-5 or direct pars repair (motion segment sparing) for more rostral SP in younger patients and if no disc degeneration or listhesis is present. Since many patients with SP undergoing ...
Shah S - - 2011
BACKGROUND AND PURPOSE: Previous studies have quantified CSF flow in patients with Chiari I at the foramen magnum with single-axial or single-sagittal PCMR. The goal of this study was to measure CSF velocities at multiple cervical spinal levels in patients with Chiari I malformation. MATERIALS AND METHODS: In a patient ...
Riise Rolf - - 2011
Aim  Rett syndrome is a neurodevelopmental disorder starting in early childhood with devastating consequences both on the brain and on systemic neurons. Scoliosis is a common complication in most of these patients. The aim of the study was to describe the prevalence of scoliosis, classify spinal deformity, and evaluate the ...
Lee Joon Woo - - 2011
OBJECTIVE: To assess diffusion tensor imaging (DTI) parameters in cervical compressive myelopathy (CCM) patients compared to normal volunteers, to relate them with myelopathy severity, and to relate tractography patterns with postoperative neurologic improvement. SUBJECTS AND METHODS: Twenty patients suffering from CCM were prospectively enrolled (M:F = 13:7, mean age, 49.6 years; range 22-67 years) ...
Takasu Miyuki - - 2011
Purpose: To evaluate the accuracy of trabecular analysis of the lumbar spine by using multidetector computed tomography (CT) in differentiating multiple myeloma patients without spinal fractures from control subjects. Materials and Methods: This retrospective single-institution study was approved by the institutional review board, with a waiver of informed consent. Spinal ...
Vidal Claudio Henrique Fernandes - - 2011
In neuroschistosomiasis, the spinal cord is the most common place of the disease. In high prevalent areas for schistosomiasis mansoni, the clinical alertness is important for an early diagnostic, in order to decrease the final neurological damage. This study provides some useful neurologic information about a series of patients with ...
Riesenburger Ron I - - 2011
The presence of a supernumerary posterior atlantoaxial facet joint has not been reported in the literature. To describe a patient who presented with a unilateral anomalous posterior facet joint and discuss its possible embryological origin. Case report. A 35-year-old woman presented with severe neck pain, headaches, and tingling radiating down ...
Harada Masafumi - - 2011
Amino acids related to neurotransmitters and the GABAergic/glutamatergic system were measured using a 3 T-MRI instrument in 12 patients with autism and 10 normal controls. All measurements were performed in the frontal lobe (FL) and lenticular nuclei (LN) using a conventional sequence for n-acetyl aspartate (NAA) and glutamate (Glu), and the ...
Struhal Walter - - 2011
Introduction: Ischemia in the distribution of the posterior spinal artery is rare. Methods: Between 2004 and 2008 we observed 4 patients with posterior spinal artery ischemia (PSAI). Results: All patients had the expected loss of posterior column function but also suffered from motor deficits which were severe, and the leading ...
Fehlings Michael - - 2011
The Rho pathway has been shown to be important in the neuronal response to growth inhibitory proteins after CNS injury. BA-210 (trademarked as Cethrin®) blocks activation of Rho and has shown promise in preclinical animal studies of spinal cord injury. This is a report of a Phase I/IIa clinical study ...
Leung Ying-Ying - - 2011
Axial psoriatic arthritis (PsA) represents a more severe form of disease than peripheral PsA. We evaluate the usefulness of various spinal mobility measurements in predicting a radiographically defined axial PsA. A cross-sectional study on PsA patients with spinal mobility measurement performed. PsA were classified to axial or peripheral PsA by ...
Yarbrough Chester K - - 2011
Object A subset of patients with Chiari malformation Type I (CM-I) presented with acute onset of a neurological deficit. In this study the authors summarize their experience with these patients' clinical presentation, imaging results, timing of surgery, and outcome following decompression. Methods The authors reviewed clinical records, imaging studies, and ...
Koeppen Arnulf H - - 2011
Friedreich's ataxia (FRDA) affects very young persons. In a large series, the mean ages of onset and death were 11 and 38 years, respectively. The clinical spectrum of FRDA has expanded after genetic confirmation of the mutation became a routine laboratory test. The main cause of death in juvenile-onset FRDA is ...
Kıymaz Nejmi - - 2011
Objective: Cervical spinal dysraphism is a rare congenital spinal pathology. The results obtained from our series are compared with the results obtained from other series of studies in the literature. Methods: Seven patients with cervical myelomeningocele and meningocele who underwent surgery between January 1996 and March 2009 at the YYU ...
Hong Jae-Young - - 2011
ABSTRACT:: Study Design. Prospective radiological analysis of patients with achondroplasia.Objective. To analyze sagittal spinal alignment and pelvic orientation in achondroplasia patients.Summary of Background Data. Knowledge of sagittal spinopelvic parameters is important for the treatment of achondroplasia, because they differ from those of the normal population and can induce pain.Methods: The ...
Wakerley Benjamin - - 2011
Background. Long-term immunosuppression with oral corticosteroids is frequently used to treat inflammatory diseases of the lung and is advocated in the management of some patients with asthma. Methods. The authors describe the case of a 35-year-old man with severe refractory asthma who developed a slowly progressive thoracic spinal cord syndrome. ...
van Rijn Monique A - - 2011
Complex regional pain syndrome (CRPS) generally remains restricted to one limb but occasionally may spread to other limbs. Knowledge of the spreading pattern of CRPS may lead to hypotheses about underlying mechanisms but to date little is known about this process. The objective is to study patterns of spread of ...
Muralidharan Rajanandini - - 2011
STRUCTURED ABSTRACT:: STUDY DESIGN: Retrospective consecutive case series.OBJECTIVES: To assess the symptoms, neurological signs, and radiological findings in a large series of patients with myelopathy due to SDAVF.SUMMARY OF BACKGROUND: The clinical diagnosis of spinal dural arteriovenous fistula SDAVF is difficult because presenting symptoms and signs can be similar to ...
Epstein Nancy E - - 2011
STUDY DESIGN: The focus of this study was on the frequency of negative initial/subsequent ultrasound (US) of the lower extremities but positive spinal computed tomography contrast angiography (CTA) diagnostic of pulmonary embolism (PE) among 75 patients undergoing cervical laminectomy/fusion and 165 patients having lumbar laminectomy/noninstrumented fusion. OBJECTIVE: To determine the ...
Plotkin Scott R - - 2011
Object The aim of this paper was to define the clinical characteristics of spinal ependymomas associated with neurofibromatosis Type 2 (NF2). Methods The authors retrospectively reviewed the clinical records of patients with NF2 who had imaging findings consistent with ependymomas and were seen at Massachusetts General Hospital between 1994 and ...
Wang Kai-Chen - - 2011
Background and Objective: It was the aim of this study to determine the prevalence of anti-aquaporin 4 antibody (anti-AQP4 Ab) and long spinal cord lesions in neuromyelitis optica (NMO) and multiple sclerosis (MS) patients in Taiwan. Asia has a relatively high rate of NMO compared with MS patients. Anti-AQP4 Ab ...
Chung Fa-Po - - 2011
BACKGROUND: Alteration in ventricular repolarization has been reported in patients with spinal cord injuries (SCIs). However, its clinical impact remains unclear. OBJECTIVES: The study investigated the correlation between SCIs and ventricular repolarization, and the associated clinical impact. METHODS: One hundred and forty-four patients with an SCI were retrospectively reviewed, and ...
Jiang Sheng-Dan - - 2011
Degenerative cervical spondylolisthesis has received insufficient attention, in contrast to degenerative lumbar spondylolisthesis. In fact, degenerative cervical spondylolisthesis may be more common than previously thought. In order to provide appropriate guidelines for the treatment of degenerative cervical spondylolisthesis, a systematic review of degenerative cervical spondylolisthesis was performed. An English literature ...
Chang Chein-Wei - - 2011
The Trömner sign is commonly used as a clinical neurological examination for upper motor neuron lesions above the fifth or sixth cervical segments of the spinal cord. This study aims to assess and quantify the Trömner signs utilizing electrophysiological test, and correlate to the severity of cord compression in cervical ...
Imagama Shiro - - 2011
Study Design. Prospective, multicenter study.Objective. To conduct peripheral arterial disease (PAD) screening on Intermittent claudication (IC) patients with lumbar spinal canal stenosis (LSCS) to examine the relationships among combined LSCS and PAD, symptoms, and physical findings.Summary of Background Data. IC occurs due to two underlying diseases, LSCS and PAD, and ...
Afridi Hassan Imran - - 2011
The consequence of a deficiency in trace elements has been associated with an increased risk of human immunodeficiency virus type 1 (HIV-1) disease progression and mortality. This study examined the association between high scalp hair and blood arsenic, cadmium, lead, and nickel concentrations and opportunistic infections in hospitalized patients with ...
Harrop James S - - 2011
Retrospective. With approximately 10,000 new spinal cord injury (SCI) patients in the United States each year, predicting public health outcomes is an important public health concern. Combining all regions of the spine in SCI trials may be misleading if the lumbar and sacral regions (conus) have a neurologic improvement at ...
Chotik-anuchit Songkram - - 2011
To study the demographic data of optico-spinal inflammatory demyelinating disease (OS-IDD) patients at Siriraj Hospital between January 1997 and October 2006. Retrospective study of OS-IDD patients. There were 84 OS-IDD patients. Cerebrospinal fluid analysis revealed higher white blood cell count and neutrophilia in neuromyelitis optica (NMO) patients than those of ...
Shimizu Yuko - - 2011
Optic neuritis and myelitis are manifestations in both multiple sclerosis (MS) and neuromyelitis optica (NMO). But unlike MS, NMO is characterized by severe optic neuritis, longitudinally extensive and transverse myelitis, and the presence of aquaporin-4 antibody. Since patients with optic neuritis and myelitis have often been diagnosed with "optic-spinal MS ...
Oktenoglu Tunc T American Hospital, Department of Neurosurgery, Istanbul, Turkey. - - 2011
Spontaneous pyogenic spinal epidural abscess (SEA) is a rare condition but might be devastating and fatal. Traditional treatment is surgical decompression and antibiotics. A retrospective study was designed to assess the eff ect of clinical findings and treatment methods on the outcome. 14 patients were reviewed (10 male, 4 female, ...
Guinet Amandine A Service de Neuro-Urologie et Explorations Périnéales, Unité de Recherche UMRS 731 UPMC Paris VI, Hôpital Tenon APHP, 4 Rue de Chine, 75970, Paris Cedex 20, France. - - 2011
Rectoanal inhibitory reflex (RAIR) is a physiological reflex implicated in anorectal continence. A lack of RAIR modulation is only described in spinal cord-injured patients with a lesion under L2. No quantitative data has been published concerning the normal modulation in amplitude and in duration in functional disorders. A retrospective analysis ...
Murillo Narda - - 2010
OBJECTIVE: Spasticity is common after spinal cord injury (SCI). Exaggerated tendon jerks, clonus, and spasms are key features of spasticity that result from hyperexcitability of the stretch reflex circuit. Here we studied the effects of vibration on the rectus femoris muscle (RF) on clinical and electrophysiological measures of spasticity in ...
Ghezzi A - - 2011
Multiple sclerosis (MS) is an inflammatory demyelinating disease of the CNS caused by the interplay of genetic and environmental factors. In the last years, it has been suggested that an abnormal venous drainage due to stenosis or malformation of the internal jugular and/or azygous veins may play a major pathogenetic ...
Iida R - - 2011
A relationship between the depth of sedation as measured by the bispectral index (BIS) and spinal sensory block height in patients with light to no additional sedation has been described previously. The present study was designed to investigate the hypothesis that BIS values closely correlate with the spread of spinal ...
1 2 3 4 5 6 7 8 9 10 >