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Kiss Zoltán Z School for Ph.D. Candidates of Aesculap Academy, - - 2014
Angiotensin-converting enzyme inhibitors (ACEis) improve survival; however, their effect on erythropoiesis remains a matter of debate in this population. Since insertion/deletion (I/D) polymorphism of the angiotensin-converting enzyme (ACE) gene largely influences serum ACE activity, its effect on erythropoiesis is also anticipated. In this multicentre, cross-sectional study of 660 patients on ...
Loh Tze Ping TP Department of Laboratory Medicine, National University Hospital, Singapore, - - 2014
We aim to develop smoothed continuous 2.5th and 97.5th percentile values for labile glycated haemoglobin A1c to glycated haemoglobin A1c (LHbA1c:HbA1c) ratio against HbA1c, and apply them on our patient population for identification of potentially spurious HbA1c measurements. The LHbA1c and HbA1c were measured using Bio-rad Variant II high-performance liquid ...
Martinez-Pinna R - - 2014
Iron deposits are observed in tissue of abdominal aortic aneurysm (AAA) patients, although the underlying mechanisms are not completely elucidated. Therefore we explored circulating markers of iron metabolism in AAA patients, and tested if they could serve as biomarkers of AAA. Increased red blood cell (RBC)-borne iron retention and transferrin, ...
Rosland Ragnhild G - - 2014
Treating anaemia with red blood cell (RBC) transfusion is frequent, but controversial, in patients with septic shock. Therefore we assessed characteristics and outcome associated with RBC transfusion in this group of high risk patients. We did a prospective cohort study at 7 general intensive care units (ICUs) including all adult ...
De Silva Nipun Lakshitha NL Tropical Medicine Research Unit, Faculty of Medicine, University of Colombo, 25 Kynsey Road, Colombo 08, Sri - - 2014
Leptospirosis presents diagnostic challenges to clinicians, in settings where other acute febrile illness are prevalent. The patterns of serial changes in haematological parameters in leptospirosis has not been evaluated previously. Clinical and laboratory data were collected prospectively from patients with leptospirosis in two hospitals in Sri Lanka. Leptospirosis was diagnosed ...
Li Qing Q Shanghai Centre for Clinical Laboratory, Shanghai, - - 2013
The aim of this study is to investigate the interference of carbamylated haemoglobin (cHb) to haemoglobin A1c (HbA1c) measurements in patients with chronic kidney disease (CKD) by three ion-exchange chromatography methods. We included three ion-exchange chromatography methods (Bio-Rad VariantII, G7 and HA-8160) and one affinity chromatography method (Primus Ultra2) to ...
Isaacs John D - - 2013
Our objective was to determine the interrelationships of interleukin (IL)-6 receptor inhibition with haemoglobin, acute-phase reactants and iron metabolism markers (including hepcidin) in patients with rheumatoid arthritis (RA). Data of patients receiving tocilizumab or placebo in the MEASURE study were analysed. We investigated associations at baseline and during tocilizumab treatment ...
Babiloni Claudio - - 2013
Cerebral vasomotor reactivity (VMR) and coherence of resting state electroencephalographic (EEG) rhythms are impaired in Alzheimer's disease (AD) patients. Here we tested the hypothesis that these two variables could be related. We investigated VMR and coherence of resting state EEG rhythms in nine normal elderly (Nold) and in 10 amnesic ...
Furst Daniel E DE UCLA Medical School, Rheumatology Division, 1000 Veteran Avenue, Rehab Center rm 32-59, Los Angeles, CA 90095-1670, USA. - - 2013
To evaluate the effect of golimumab on haemoglobin levels in patients with RA, PsA or AS. Secondary analysis was performed on integrated data from five randomized controlled studies: three RA, one PsA and one AS (2303 patients total). Golimumab 50 or 100 mg was injected s.c. every 4 weeks with ...
Trowbridge Lynette - - 2013
BACKGROUND: Anaemia often goes unrecognised in people with early chronic kidney disease (CKD) resulting in under treatment until reaching the need for dialysis. OBJECTIVES: This study aimed to determine if anaemia is adequately treated in Australians with CKD, who do not require dialysis. DESIGN AND MEASUREMENT: Haemoglobin, ferritin and transferrin ...
Bava Bava Amadeo Javier - - 2013
To communicate the presence of adult females, rabditoid larvae and eggs of Strongyloides stercoralis (S. stercoralis) in the respiratory secretions obtained by tracheal aspirate from a HIV-negative patient who was suffering from polymyositis, and treated with corticoids and amethopterin and assisted by pneumonia. The respiratory secretions submitted to the Parasitology ...
Hörl Walter H - - 2013
Renal anaemia is a frequent complication in patients with chronic kidney disease (CKD). Severe anaemia (haemoglobin <90 g/l) is associated with increased risks of mortality and cardiac complications, such as left ventricular hypertrophy and cardiovascular disease, and impaired quality of life. Randomized controlled trials have tested the hypothesis that increasing ...
Kalicki Robert M - - 2013
In chronic haemodialysis patients, anaemia is a frequent finding associated with high therapeutic costs and further expenses resulting from serial laboratory measurements. HemoHue HH1, HemoHue Ltd, is a novel tool consisting of a visual scale for the noninvasive assessment of anaemia by matching the coloration of the conjunctiva with a ...
Joosten Etienne - - 2012
BACKGROUND: Iron deficiency anaemia (IDA) and anaemia of chronic disease (ACD) are common in elderly patients but there are no standard diagnostic criteria. The reticulocyte haemoglobin equivalent (Ret-He) is routinely measured by modern automated blood analysers and is an early indicator of iron deficiency. The aim of this study was ...
Ndugwa C - - 2012
To compare the haematological and clinical features of homozygous sickle cell (SS) disease in Bantu and Benin haplotypes in a cross-sectional study of 115 Ugandan patients attending the Sickle Cell Clinic at Mulago Hospital, Kampala, Uganda, with 311 patients in the Jamaican Cohort Study This involved comparison of clinical features ...
Verschoore Michèle - - 2012
Idiopathic cutaneous hyperchromia at the orbital region (ICHOR) is a cutaneous hyperchromia characterised by bilateral darkening of the eyelid and orbital skin that contrasts with the adjoining facial skin. ICHOR is frequent in dark skin. It interferes with the face appearance which often causes difficulties in societal acceptance and may ...
Khattak Muhammad Bilal - - 2012
A wide variety of clinical conditions, that primarily or secondarily affect the bone-marrow may present with pancytopenia, one of such conditions is megaloblastic anaemia. The purpose of this study was to determine the frequency and nature of pancytopenia in megaloblastic anaemia. This was a prospective, cross-sectional descriptive study conducted in ...
Henninger Benjamin - - 2012
OBJECTIVE: Our purpose was to evaluate whether antiandrogen therapy (AAT) influences [F]choline PET results in patients with biochemical recurrence after radical prostatectomy (RPE). METHODS: Through a retrospective study we evaluated two groups of patients, both with histologically proven carcinoma of the prostate, who had undergone RPE and a subsequent [F]choline ...
Mehta Akanksha - - 2012
Study Type - Therapy (case series) Level of Evidence 4 What's known on the subject? and What does the study add? Climacturia is present in ∼20-40% of men after radical prostatectomy, and adversely affects sexual satisfaction. Although several strategies have been proposed for the treatment of climacturia, none have been systematically ...
Jeong In Gab - - 2012
INTRODUCTION: Preoperative factors favoring the performance of non-orthotopic bladder substitution (OBS) after radical cystectomy for muscle-invasive bladder cancer were identified. PATIENTS AND METHODS: We retrospectively reviewed the medical records of 730 patients who underwent radical cystectomy for urothelial carcinoma of the bladder. After excluding 75 patients who were unable to ...
Roethke Matthias C - - 2012
PURPOSE: To evaluate the accuracy of presurgical endorectal MRI (eMRI) for local staging before radical prostatectomy (RP) and its influence on neurovascular bundle (NVB) resection during radical prostatectomy. PATIENTS AND METHODS: A total of 385 patients with histologically proven prostate cancer (PCa) have been included in this retrospective study between ...
Hazewinkel Menke H - - 2011
BACKGROUND: Hydronephrosis can be a side effect of radical hysterectomy for cervical cancer. The incidence of clinically relevant hydronephrosis has not been studied in a large sample and the benefit of early detection of hydronephrosis is not clear. OBJECTIVE: To assess the incidence of hydronephrosis, following radical hysterectomy and evaluate ...
Martini Thomas - - 2012
Introduction. (11)C-choline-PET/CT is a promising technique for detection/restaging of patients with biochemical failure (BF) after curative therapy for prostate cancer (PCA). The aim of this paper was to evaluate the PSA response in patients with BF after radical prostatectomy (RP) who underwent secondary lymphadenectomy (LAD) due to (11)C-choline-PET/CT findings. Material ...
Adhikary L - - 2011
Introduction: Anemia is the most common finding in chronic kidney disease patients. Iron supplements are commonly prescribed for these patients with or without erythropoietin therapy by means of oral and intravenous iron. Both oral and intravenous irons have their own advantage and disadvantage, and the efficacy is also different. The ...
JarzÄ…bek Magdalena - - 2011
Only 10 to 20% of patients with hepatic metastases qualify for radical resection of their lesions. The treatment issue among the rest of patients is a small clinical response to overall chemiotherapy and the frequent inability to treat patients with percutaneous thermoablation. In the latter circumstance, parallel to the radical ...
Emre Sevinc - - 2011
Aim:  Associations between several vascular diseases such as Kawasaki disease, venous and arterial thromboembolism, cardiovascular disease, diabetic nephropathy, focal segmental glomerulosclerosis and methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism have been reported. This is a clinical study designed to investigate the possible effects of MTHFR C677T polymorphism on the development of Henoch-Schönlein ...
Hamurcu Zuhal - - 2011
Acromegaly is a syndrome characterized by a sustained elevation of circulating growth hormone and insulin-like growth factor-1 (IGF-1). Insulin-like growth factor-1 is a potent mitogen and has a role in the transformation of normal cells to malignant cells. This study aims to evaluate the spontaneous micronucleus (MN) frequency by using ...
Eldesoky Ayman - - 2011
Some biological factors play a role in stimulation of malignant growth, metastasis and angiogenesis; however, their clinical relevance has not yet been well established for most of them. This work was aimed at studying the clinical relevance of serum vascular endothelial growth factor (VEGF) and interleukin-6 (IL-6), in patients with ...
Shigematsu H - - 2011
Hepatocyte growth factor is a potent angiogenic agent. This study investigated the efficacy and safety of intramuscular injection of naked plasmid DNA encoding the human hepatocyte growth factor gene in Japanese patients with Buerger's disease and critical limb ischemia. An open-label clinical study was performed at eight hospitals in Japan ...
Buyuklu Fuat - - 2011
Objective. To investigate the clinical features of paranasal sinus osteomas and to estimate the growth rate of these tumors in a large series of patients. Design. Case series with chart review. Setting. University hospital, tertiary referral center. Subjects and Methods. The authors retrospectively reviewed the paranasal sinus tomography scans that ...
Perkel David - - 2011
Heart failure (HF) is an important health concern with almost a quarter million deaths each year despite advances in medical therapy. Improvement of cardiac function has been shown to reduce morbidity and mortality in patients with HF. There has been recent interest in the growth hormone (GH) / insulin-like growth ...
Lee Joonho - - 2011
To determine the clinical significance of an increase in various fragmented forms of insulin-like growth factor binding protein-1 (IGFBP-1) in amniotic fluid (AF), a retrospective cohort study was conducted in 103 consecutive patients with preterm labor and intact membranes. Amniotic fluid samples were cultured for aerobic and anaerobic bacteria, and ...
Douet-Guilbert Nathalie - - 2011
Cytogenetic abnormalities identified by conventional cytogenetics (CC) have important prognostic and therapeutic roles in myelodysplastic syndromes (MDS). Fluorescence in situ hybridization (FISH) complements CC since it is able to evaluate large numbers of interphase and metaphase nuclei. The question has been raised as to whether interphase FISH in addition to ...
Wagenmakers Margreet Albertina E M - - 2011
Transsphenoidal pituitary surgery (TS) is the primary treatment of choice for patients with acromegaly. Macroadenomas (>1 cm) are more difficult to resect than microadenomas (remission rate ± 50% compared to ± 90%). Besides the conventional microscopic TS, the more recently introduced endoscopic technique is nowadays frequently used. However, no large series ...
Bogazzi Fausto - - 2011
ObjectiveTo evaluate the impact of different peak GH cut-offs after GHRH-Arg, IGF1 or their combination in identifying GHD.Design and Patients894 controls(used for normative IGF1 levels) and 302 patients with suspected GHD. Different peak GH cut-off limits[used by European or North American(4.1 μg/l) Endocrine societies, by HypoCCs(2.5 μg/l), or with 95% ...
Starker Lee F - - 2011
The clinical and pathological characteristics of hyperparathyroidism-induced hypercalcemic crisis (HIHC) are incompletely described. The present study was designed to elucidate the nature and effects of HIHC in patients undergoing parathyroidectomy in our unit. A prospective database of 1,754 consecutive patients with primary hyperparathyroidism (PHPT) who underwent parathyroidectomy from 1991-2009 identified ...
Gardner Chris J - - 2011
OBJECTIVE: Hurler Syndrome, (MPSIH) is an inborn error of glycosaminoglycan metabolism. Haematopoietic stem cell transplantation (HSCT) has transformed the prognosis for these children. Prior to transplant patients receive chemotherapy or chemo-radiotherapy. Regular screening for the development of endocrine sequelae is therefore essential. We present for the first time data on ...
Patil Sangita P - - 2011
Clinical outcomes of patients with asthma are highly variable. Immunological biomarkers associated with asthma control have not been elucidated. To identify the association between clinical control of asthma and serum immunological profiles of asthmatics and compare these profiles with those of healthy controls by using a multiplex assay. Sera were ...
Bergenfelz Anders O J - - 2011
The purpose of this study is to investigate the results of first-time surgery for sporadic primary hyperparathyroidism (pHPT) in patients with preoperatively negative sestamibi scintigraphy and ultrasound. Data were gathered prospectively in a multicenter database for quality control in parathyroid surgery. Between 2004 and 2008, 3,158 patients underwent first-time surgery ...
Soo I - - 2011
Spontaneous rupture of tendons is rare, and typically occurs in large weight bearing tendons such as the quadriceps, Achilles and patellar tendon, in the context of various chronic diseases including end-stage renal disease. In general, tendon rupture in dialysis patients is associated with hyperparathyroidism, long duration of dialysis, steroid and ...
Lin H-P - - 2011
The objective of this study was to test the efficacy of three different treatment modalities on the reduction of serum anti-gastric parietal cell autoantibody (GPCA) level in GPCA-positive oral lichen planus (OLP) patients. Of 147 GPCA-positive OLP patients, 100 were treated with levamisole plus vitamin B12, 10 with vitamin B12 ...
Milman Sofiya - - 2011
Objective: To report a case of proton pump inhibitor-induced hypocalcemic seizure in a patient with hypoparathyroidism.Methods: We describe the clinical history, physical examination findings, and laboratory values of the patient and briefly review the relevant literature.Results: A 48-year-old woman with a history of postsurgical hypoparathyroidism who was taking calcium carbonate, ...
Witteveen Janneke E - - 2011
In primary hyperparathyroidism (PHPT) the predictive value of technetium 99m sestamibi single emission computed tomography (Tc99m-MIBI-SPECT) for localizing pathological parathyroid glands before a first parathyroidectomy (PTx) is 83-100%. Data are scarce in patients undergoing reoperative parathyroidectomy for persistent hyperparathyroidism. The aim of the present study was to determine the value ...
Kim Sook Kyoung - - 2011
The degree of electroanatomical remodeling of the left atrial (LA) affects the clinical outcome after rhythm control of atrial fibrillation (AF). Our hypothesis was that plasma concentrations of transforming growth factor (TGF)-β and tissue inhibitor of metalloproteinase (TIMP)-1 reflect LA voltage and structural remodeling in patients with non-valvular AF. In ...
Wassenaar M J E - - 2011
To compare the distribution of osteophytes and joint space narrowing (JSN) between patients with acromegaly and primary generalised osteoarthritis to gain insight into the pathophysiological process of growth hormone (GH) and insulin-like growth factor type I (IGF-I)-mediated osteoarthritis. We utilised radiographs of the knee and hip joints of 84 patients ...
de Paula T P - - 2010
The liver is the main organ involved in homeostasis, metabolism and the storage of retinol. During the fibrotic process, hepatic stellate cells lose their lipid drops, and retinol reserves may deplete. Thus, the present study aimed to evaluate serum retinol levels (RL), hepatic retinol storage and dietary vitamin A intake ...
Yáñez-Vico Rosa-María - - 2010
The purpose of this study was to analyze craniofacial characteristics from lateral head profile radiographs of patients with cri-du-chat (CdC) syndrome. The craniofacial morphology of 10 CdC patients was evaluated using standard cephalometric methods, measuring 39 craniofacial variables on cephalometric x-ray images. The principal characteristics were skeletal class II malocclusion, ...
Raedle-Hurst Tanja M - - 2010
In patients after the Fontan procedure, assessment of ventricular function is difficult and amino-terminal pro-B-type natriuretic peptide levels failed to be directly related to echocardiographic measures of systolic ventricular function. The aim of the study was to evaluate growth differentiation factor 15 (GDF-15), a marker of various stress pathways in ...
Coveney Natalie - - 2010
Patients on extended hours (>15 h/week) hemodialysis may be at a higher risk of deficiency of water-soluble vitamins than conventional (≤15 h/week) hemodialysis patients due to their increased weekly hours of dialysis. We compared serum levels of the water-soluble vitamins in a group of extended and conventional hours hemodialysis patients. Predialysis serum ...
Briani Chiara - - 2010
POEMS syndrome and amyloidosis are rare plasma cell diseases that share common features, including polyneuropathy. The aim of this study was to investigate serum vascular endothelial growth factor (sVEGF) in patients with amyloidosis and to evaluate changes in response to treatment. Twenty-five patients [17 primary light-chain amyloidosis (AL-A), 7 transthyretin ...
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