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Mitsopoulos Efstathios - - 2011
Τhe exact mechanisms by which the effects of inflammation on erythropoiesis occur are still to be determined. We aimed to examine the relation between C-reactive protein (CRP) and erythropoiesis as quantified by the absolute reticulocyte count (RTC) and the possible effect of iron status on this relationship. As part of ...
Kurabayashi Manabu - - 2010
Acute aortic dissection (AAD) often accompanies acute respiratory failure. The aim of this study was to clarify the relationship between the incidence of oxygenation impairment and the extent of distal type AAD. A total of 49 patients with medically treated distal type AAD were retrospectively examined. AAD% was defined as ...
Yüksel Nurşen - - 2010
PURPOSE: To evaluate the systemic high sensitivity C-reactive protein (hsCRP) levels in patients with pseudoexfoliation syndrome (XFS) and pseudoexfoliation glaucoma (XFG). MATERIALS AND METHODS: We prospectively examined 31 patients with XFS, 26 with XFG, and 25 controls. To the study patients with the exclusion of serious hypertension that do not ...
Teplan Vladimír V - - 2010
Obesity is a known high-risk factor for the development of vascular diseases and chronic kidney disease (CKD). In this study we aimed to elucidate the impact of adipose tissue on the inflammatory state in CDK patients with obesity. A cohort of 40 patients with CKD (stages 3-4) with mild proteinuria ...
Hariharan Praveen - - 2011
Previous studies in post-operative orthopedic and pediatric patients suggest that erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) testing may be helpful in ruling out septic arthritis. However, these tests have not been evaluated in a population of adult Emergency Department (ED) patients. Determine the sensitivity of ESR and CRP ...
Song Soken-Nakazawa J - - 2010
Dysregulated production of hepcidin is implicated in anemia of inflammation, whereas interleukin-6 (IL-6) is a major inducer of hepcidin production. Overproduction of IL-6 is responsible for pathogenesis of multicentric Castleman disease (MCD), a rare lymphoproliferative disorder accompanied by systemic inflammatory responses and anemia. In this study, we investigated the roles ...
Pedersen Susanne Juhl - - 2010
The objectives of the study were to investigate short and long-term changes and relations to treatment response of plasma interleukin-6 (IL-6), vascular endothelial growth factor (VEGF), YKL-40, matrix metalloproteinase-3 (MMP-3), and total aggrecan in patients with spondyloarthritis (SpA) treated with tumor necrosis factor-alpha (TNFα) inhibitors and to compare with levels ...
Ishii Hideki - - 2010
Endovascular therapy (EVT) has been widely performed for peripheral artery disease. However, the high restenosis rate after EVT remains a major problem in patients on hemodialysis. Recent studies suggest that C-reactive protein (CRP) reflects vascular wall inflammation and can predict adverse events. We evaluated the possible prognostic values of CRP ...
Nishikawa Takuro - - 2010
BACKGROUND: Early markers for predicting the severity of neutropenic fever (NF) in patients with hemato-oncological patients have not yet been established. Reactive oxygen species are known to play an important role in the antimicrobial function of neutrophils. The aim of this study was to determine the serum levels of derivatives ...
Manfredini Vanusa - - 2010
Type 2 diabetes (T2D) is associated with increased oxidative stress as indicated by elevated levels of lipid peroxidation and protein oxidation products. Since reactive oxygen species (ROS) can cause damage to biological macromolecules including DNA, this study investigated oxidative damage to DNA using the alkaline (pH > 13) comet assay ...
Lee Li-Ang - - 2010
OBJECTIVE: To evaluate the clinical factors predicting the significantly elevated high-sensitivity C-reactive protein (hs-CRP) concentrations, defined herein as hs-CRP > or = 3 mg/L, in adult males with untreated obstructive sleep apnea syndrome (OSAS). STUDY DESIGN: Cross-sectional study. SETTING: Tertiary referral center. SUBJECTS AND METHODS: Sixty-five consecutive male patients with ...
Tasaka Sadatomo - - 2010
The clinical features of PCP differ according to the factors responsible for the predisposing immunosuppression. Although the diagnosis of PCP often requires BAL, the profiles of the inflammatory mediators in the BAL fluid are not thoroughly documented. The aim of the current study was to characterize the profiles of inflammatory ...
Kuchtey John - - 2010
To test the hypothesis that immune activation occurs in glaucoma by comparing concentrations of multiple cytokines in aqueous humor (AH) from patients with primary open angle glaucoma (POAG) and from cataract patients without glaucoma as controls. Cytokine concentrations in AH obtained during surgery were measured using microparticle-based immunoassays. Localized expression ...
Daniels Johannes M A - - 2010
Rational prescription of antibiotics in acute exacerbations of COPD (AECOPD) requires predictive markers. We aimed to analyze whether markers of systemic inflammation can predict response to antibiotics in AECOPD. We used data from 243 exacerbations out of 205 patients from a placebo-controlled trial on doxycycline in addition to systemic corticosteroids ...
Sidoroff Marianne M Hospital for Children and Adolescents, University of Helsinki, Helsinki, FIN-00029, Finland. - - 2010
To study whether high-sensitivity C-reactive protein (hs-CRP) measurement can aid the assessment of disease activity and glucocorticoid treatment in paediatric inflammatory bowel disease (IBD). CRP levels were measured in 39 children with IBD undergoing colonoscopy [median age 12.8 years, Crohn's disease (CD) n = 20], in 22 other children with ...
Fury Wen - - 2010
Intravenous immunoglobulin (IVIG)-resistant Kawasaki disease (KD) patients comprise at least 20% of treated patients and are at high risk for coronary artery abnormalities. If identified early in the course of the disease, such patients may benefit from additional anti-inflammatory therapy. The aim of this study was to compare the transcript ...
El-Solh Ali A - - 2010
The significance of residual excessive daytime sleepiness (EDS) on cardiovascular markers in patients with adequately treated obstructive sleep apnea (OSA) remains unclear. The objective of this study was to investigate flow-mediated dilatation (FMD) and inflammatory markers (C-reactive protein [CRP], tumor necrosis factor [TNF]-alpha, and interleukin [IL]-6) in continuous positive airway ...
Song In-Uk - - 2011
Although neuroinflammation is known to play an important role in the pathogeneses of neurodegenerative diseases, few studies have been conducted on the association between Parkinson's disease (PD) and high-sensitivity C-reactive protein (hs-CRP), which is the most studied biomarker of systemic inflammation. Therefore, we conducted this study to determine the clinical ...
Wiernicki Ireneusz - - 2010
Haptoglobin (Hp) polymorphism is associated with the prevalence and clinical evolution of many inflammatory diseases and atherosclerosis. Circulating neutrophils and neutrophil-associated proteases are an important initial component of experimental abdominal aortic aneurysm (AAA) formation. Elastase and C-reactive protein (CRP) levels are elevated in patients with AAAs. This study assessed the ...
Horiuchi Yuki - - 2010
AIM: Hypercholesterolemic patients with inflammation are at high risk for cardiovascular events. Statins exert anti-inflammatory action independent of their cholesterol-lowering action. This study sought to clarify whether statin therapy reduces inflammatory markers in hypercholesterolemic patients and to determine factors that predict the reduction in these markers. METHODS: Fasting concentrations of ...
Basic Jelena - - 2010
Genetic contribution of tumor necrosis factor polymorphism (TNF-alpha-308G/A) in patients with juvenile idiopathic arthritis (JIA) on response to TNF blocking agents, as well as matrix metalloproteinase-9 (MMP-9) production, is not yet well established. We have investigated whether the TNF-alpha-308G/A polymorphism can influence MMP-9 level and clinical response to etanercept (TNF ...
Yadav Dinesh - - 2010
OBJECTIVE: To find out etiology and clinical course of thrombocytosis in Indian pediatric population. METHODS: A total of 250 patients having thrombocytosis (defined as platelet count >500 x 10(9)/L) on haematological investigations were studied over one yr period. All patients were evaluated clinically and were subjected to investigations, including complete ...
Don B R - - 2010
BACKGROUND: Inflammation strongly predicts all-cause and cardiovascular mortality among dialysis patients. The negative acute-phase proteins, albumin and prealbumin are both inversely associated with mortality. Both albumin and prealbumin levels are decreased by inflammation. We carried out a pilot study to establish whether treatment with the tumor necrosis factor-alpha; receptor antagonist ...
van der Zee P M - - 2010
BACKGROUND: C-reactive protein (CRP) is elevated in patients with acute myocardial infarction (AMI). When CRP binds to membrane phospholipids or Fc receptors, it activates the complement system. Recent studies show that CRP can be exposed on cell-derived microparticles (MP) and is associated complement activation. OBJECTIVES: We studied complement activation on ...
Garc?a-Mart?nez Ana - - 2010
OBJECTIVE: To assess the clinical relevance of increased circulating cytokines in patients with giant cell arteritis (GCA) after long-term followup. METHODS: We performed a cross-sectional evaluation of 54 patients with biopsy-proven GCA prospectively followed for a median of 5.4 years (range 4-10.5 years). GCA-related complications, vascular events, relapses, current prednisone ...
Poddubnyy D A - - 2010
OBJECTIVE: This study was aimed at comparing high sensitivity C reactive protein (hsCRP) measurement with routine C reactive protein (CRP) evaluation as disease activity parameters in patients with ankylosing spondylitis (AS) and non-radiographic axial spondyloarthritis (nrSpA). METHODS: A total of 269 patients (153 with AS and 116 with nrSpA) were ...
Pellicelli Adriano M - - 2010
Portopulmonary hypertension (PPHTN) is a rare complication in patients with portal hypertension. A role of endothelin 1 (ET-1) and other cytokines was demonstrated in primary pulmonary hypertension but not in PPHTN. We evaluated the possible role of ET-1, interleukin 6 (IL-6), interleukin 1β (IL-1β), and tumor necrosis factor alpha (TNF-α) ...
Shimizu Masaki - - 2010
To compare the pro-inflammatory cytokine profiles and the cytokine kinetics in patients with secondary macrophage activation syndrome (MAS) due to systemic-onset juvenile idiopathic arthritis (s-JIA) and in both active and inactive disease states of s-JIA (but no MAS), with those demonstrated in EBV-induced haemophagocytic lymphohistiocytosis (HLH) and Kawasaki disease (KD), ...
Barbosa Izabela Guimarães - - 2011
Bipolar disorder (BD) has been associated with a proinflammatory state in which TNF-α seems to play a relevant role. The aim of the present study was to evaluate the plasma levels of TNF-α and its soluble receptors (sTNFR1 and sTNFR2) in BD patients in mania and euthymia in comparison with ...
Ohtsuka Tsutomu - - 2010
BACKGROUND: Chronic idiopathic urticaria (CIU) is often resistant to common treatment of uriticaria. OBJECTIVE: To find out clinical and laboratory findings affecting the response of oral cyclosporine therapy in CIU. SUBJECTS AND METHODS: The response of oral cyclosporine therapy in 15 patients with CIU (male:female = 5:10, age 16-60 years ...
Song I-H - - 2010
OBJECTIVE: Histologic studies have shown B cell clusters in the subchondral bone marrow of the spine of patients with ankylosing spondylitis (AS). An immunotherapy targeting B cells in AS is therefore of interest. We undertook this study to examine the efficacy and safety of rituximab in patients with AS refractory ...
Stapleton Renee D - - 2010
Obesity is associated with poor outcomes in many diseases, although recent data suggest that acute lung injury (ALI) is an exception. This is particularly interesting because obesity is marked by increased levels of proinflammatory mediators associated with increased morbidity and mortality in ALI. We hypothesized that cytokine response might be ...
Hensor Elizabeth M A EM Section of Musculoskeletal Disease, Leeds Institute of Molecular Medicine, University of Leeds, UK. - - 2010
The 28-joint disease activity score (DAS-28) guides the use of biologics in RA. The aims of this study were to investigate agreement between the ESR- and CRP-based DAS-28 definitions, and to examine how this agreement may be improved. Data were obtained from registers of early (n = 520) and established ...
Lorenzen Johan - - 2010
BACKGROUND: Osteopontin is a pleiotropic cytokine involved in the recruitment and retention of neutrophils to sites of inflammation, which are the primary targets cells in antineutrophil cytoplasmic autoantibody-associated vasculitis (AAV). Osteopontin may play a role in the pathogenesis of AAV. METHODS: 24 patients with systemic AAV and six patients with ...
Stoica Adina Liliana - - 2010
The aim of this study was to evaluate the association between interleukin (IL)-6 and IL-10 gene polymorphism and the short-term risk of postoperative cardiovascular events in patients with peripheral artery disease receiving elective surgery and also to evaluate the endothelial function. We determined preoperatively IL-6 gene polymorphism (-174 G/C and ...
Simunović-Soskić Marica - - 2010
OBJECTIVE: The aim of this study was to monitor therapeutic response by determining the level of proinflammatory cytokines TNF-alpha and IL-6 in whole unstimulated saliva in patients with denture stomatitis (DS), before and after laser phototherapy (LPT). BACKGROUND: DS is an inflammatory condition that occurs in subjects who wear dentures, ...
Bikker A - - 2010
OBJECTIVE: To study the expression levels and immunostimulatory capacities of interleukin-7 (IL-7) in primary Sj?gren's syndrome. METHODS: Labial salivary gland (LSG) IL-7 expression was determined by immunohistochemistry, using a quantitative scoring system, in 30 patients with sicca syndrome: 15 patients with primary Sj?gren's syndrome (SS) and 15 patients with non-SS ...
Farah R - - 2010
AIM: Oxidative stress (OS) and inflammation and are among the mechanisms that have been recently implicated in pathogenesis of hyperlipidemia. Peripheral polymorphonuclear leukocytes (PMNLs) are primed in metabolic syndrome patients, which include hyperlipidemic patients, releasing uncontrolled superoxide contributing to OS and inflammation. Recent studies have attributed additional anti-ischemic and antioxidative ...
Chen H-Y - - 2010
Dialysis patients with uremic pruritus have worse outcomes. However, the pathophysiology of the high mortality in these patients remains inconclusive except for links with calcium/phosphate imbalance and sleep disturbance. Whether inflammation, an outcome predictor in dialysis patients, plays a role is unknown. This prospective study included 321 chronic hemodialysis (HD) ...
Ploder Martin - - 2010
Moderate hyperhomocysteinemia is a well-established coronary risk factor that develops when dietary supply with folate and/or vitamin B(12) is inadequate. Recently, stimulated peripheral blood mononuclear cells were shown to produce homocysteine. Thus, the stimulated immune system may contribute to moderate hyperhomocysteinemia during certain diseases. Because multiple trauma and sepsis are ...
Angulo Javier C - - 2010
OBJECTIVES: To analyze whether C-reactive protein (CRP) predicts the need for urgent urinary diversion in patients with renal colic and urolithiasis. CRP may help in the differential diagnosis of complicated hydronephrosis. METHODS: Prospective study done on 110 consecutive patients with renal colic secondary to upper urinary tract calculi admitted in ...
Liu Juan - - 2010
OBJECTIVE: To investigate the relationship of coronary heart disease (CHD)-associated factors-C-reactive protein (CRP) and lipid profiles-with periodontitis in an ethnic Han population. METHOD AND MATERIALS: Forty healthy individuals as control, 40 patients with chronic periodontitis (CP), 28 patients with CHD, and 47 patients with both CP and CHD were included ...
Demir Saliha Eroğlu - - 2010
BACKGROUND: It is not clear why complex regional pain syndrome (CRPS) develops in some patients but not in others, despite similar initiating events. The aim of this study was to investigate risk factors for CRPS in cases who had suffered traumatic upper extremity injury. METHODS: One hundred sixty-five patients who ...
Shih Hsin-Chin - - 2010
BACKGROUND:: Spleen artery embolization (SAE) increases the success of nonoperative management of spleen injury; however, the immune alternation after SAE is unclear. This study searched the endotoxin responses of peripheral blood mononuclear cells (PBMCs) in injured patients who received SAE. METHODS:: Patients were subsequently enrolled when their spleen injuries were ...
Kozdağ Güliz - - 2010
While the adverse prognostic impact of a high level of high sensitivity C-reactive protein (hs-CRP) in coronary artery disease is well known, we lack data about the prognostic importance of hs-CRP in chronic heart failure (CHF) patients. The aim was to investigate the relationship between hs-CRP and prognosis in CHF ...
Goel Ruchika - - 2010
Mycophenolate mofetil (MMf) has recently been reported as a useful alternative immunosuppressive drug in autoimmune diseases. There is paucity of literature on its use in Takayasu's arteritis (TA). The aim of this study was to assess the safety and efficacy of MMf in Asian Indian patients with Takayasu's arteritis. Records ...
Nascimento Marcelo M - - 2010
Inflammation and oxidative stress (OS) are cardiovascular risk factors in patients with chronic kidney disease. N-acetylcysteine (NAC) is a thiol-containing antioxidant with anti-inflammatory properties and has been shown to reduce the number of cardiovascular events in hemodialysis patients. The current study aimed to determine the effect of oral NAC (2 ...
He Zhihui - - 2010
BACKGROUND AND OBJECTIVE: COPD is associated not only with an abnormal inflammatory response in the lung but also with systemic inflammation, including systemic oxidative stress, activation of circulating inflammatory cells and increased circulating levels of inflammatory cytokines. Understanding the nature and course of systemic inflammation in COPD is important given ...
de Haro Miralles Joaquín - - 2010
OBJECTIVES: Endothelial dysfunction and inflammation are understood to contribute to the onset of peripheral arterial disease (PAD), and endothelin (ET) may play an important role in this process. This study investigated the role of ET in PAD, and its relationships with symptoms, endothelial dysfunction and inflammation. METHODS AND RESULTS: This ...
Kalita Jayantee - - 2010
Japanese encephalitis (JE) is the commonest encephalitis in South East Asia associated with high morbidity and mortality. Neuronal injury is attributed to a number of proinflammatory cytokines. This study evaluates cerebrospinal fluid (CSF) cytokines and chemokines in encephalitis and correlates these with clinical and magnetic resonance imaging (MRI) findings. We ...
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