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Deutsch Eric C EC Department of Pharmacology, Perelman School of Medicine at the University of Pennsylvania, , Philadelphia, Pennsylvania, - - 2014
Friedreich ataxia (FRDA) is a neurodegenerative disease caused by mutations in the frataxin (FXN) gene, resulting in reduced expression of the mitochondrial protein frataxin. Improved understanding of the pathophysiology of the disease has led to a growing need for informative biomarkers to assess disease progression and response to therapeutic intervention. ...
Sencan Arzu A Department of Pediatric Surgery, Dr. Behçet Uz Children's Trianing Hospital, Izmir, Turkey, - - 2014
To show whether Alvarado, Eskelinen, Lintula and Ohmann scoring systems have predictive values in diagnosing acute appendicitis in children. Sixty patients with suspected acute appendicitis were prospectively evaluated. Alvarado, Eskelinen, Lintula and Ohmann scores were calculated separately for each patient at the time of admission. The specificity, sensitivity, positive and ...
Jennings Douglas L DL 1 Department of Pharmacy Practice, Nova Southeastern University, Ft. Lauderdale - - - 2014
Purpose: To describe the pharmacokinetics of vancomycin in patients with continuous-flow left ventricular assist devices (CF-LVADs).Methods: Eligible patients were ≥18 years old, implanted with a Heart Mate II CF-LVAD during January 2008-April 2012, and treated with vancomycin ≥48 hours for infection. Key exclusion criteria were unstable renal function, acute heart ...
Otite Fadar F From the Department of Neurology, Stroke Division (F.O., S.M., A.M., S.C., S.O., F.A.S.), Department of Radiology (A.A.Z.), and Department of Neurosurgery (R.D.), Brigham and Women's Hospital, Boston, MA; Cardiovascular Research Laboratory and Department of Physical Medicine and Rehabilitation, Spaulding Rehabilitation Hospital, Boston, MA (C.O.T.); Institute for Aging Research, Hebrew SeniorLife, Roslindale, MA (S.P.); Harvard Medical School, Boston, MA (F.O., C.O.T., A.A.Z., A.M., S.C., S.O., S.P., R.D., F.A.S.); Department of Neurology, Klinikum Worms, Teaching Hospital of Mainz, Germany (S.M.); and Division of Neuroimaging and Neurointervention, Department of Radiology, University of Massachusetts Medical Center, Worcester, MA - - 2014
Cerebral autoregulation may be impaired in the early days after subarachnoid hemorrhage (SAH). The purpose of this study was to examine the relationship between cerebral autoregulation and angiographic vasospasm (aVSP) and radiographic delayed cerebral ischemia (DCI) in patients with SAH. Sixty-eight patients (54±13 years) with a diagnosis of nontraumatic SAH ...
Korkmaz Ahmet - - 2014
There is little data regarding the diagnostic ability of neutrophil-lymphocyte ratio (NLR) in acute coronary syndrome. Therefore, we aimed to assess the predictive value of NLR in the discrimination of troponin-positive patients. We enrolled 244 patients (mean age 61.3 ± 11.7 years, 70.5% male) who presented to the emergency service ...
Williams K M KM 1] Experimental Transplantation and Immunology Branch, National Cancer Institute, NIH, Bethesda, MD, USA [2] Division of Blood and Marrow Transplantation, Center for Cancer and Blood Disorders, Children's National Medical Center, The George Washington University Medical Center, Washington, DC, - - 2014
Bronchiolitis obliterans syndrome (BOS) is a serious complication of chronic GVHD (cGVHD) following HSCT (hematopoietic SCT). The clinical diagnosis of BOS is based on pulmonary function test (PFT) abnormalities including: FEV1<75% predicted and obstructive FEV1/VC ratio, calculated using reference equations. We sought to determine if the frequency of clinical diagnoses ...
Sun Lin L Department of Cardiology, First Affiliated Hospital of Harbin Medical University, 23 Youzheng St, Nangang District, 150001 Harbin City, Heilongjiang Province, China. - - 2014
Objectives- We investigated whether transesophageal echocardiography (TEE) assisted with a computer-aided diagnostic (CAD) algorithm was superior to TEE in diagnosing left atrial (LA)/left atrial appendage (LAA) thrombi in patients with atrial fibrillation (AF) in a single prospective study. Methods- Transesophageal echocardiography was performed in patients with AF, and images were ...
As'habi A A Faculty of Nutrition and Food Technology, Shahid Beheshti University of Medical Sciences, Tehran, Islamic Republic of - - 2014
The present study was designed to determine the cutoff points for the diagnosis of mild-to-moderate and severe protein-energy wasting (PEW) based on dialysis malnutrition score (DMS) and malnutrition inflammation score (MIS), and the sensitivity, specificity, accuracy, area under receiver operating characteristic (ROC) curve, positive predictive value (PPV), negative predictive value ...
Tomaiuolo Giovanna G Dipartimento di Ingegneria Chimica, dei Materiali e della Produzione Industriale, Università di Napoli Federico II, Napoli, Italy ; CEINGE-Advanced Biotechnologies, Napoli, - - 2014
In cystic fibrosis (CF) patients airways mucus shows an increased viscoelasticity due to the concentration of high molecular weight components. Such mucus thickening eventually leads to bacterial overgrowth and prevents mucus clearance. The altered rheological behavior of mucus results in chronic lung infection and inflammation, which causes most of the ...
Palamaner Subash Shantha Ghanshyam G Department of Internal Medicine, The Wright Center for Graduate Medical Education, Scranton, Pennsylvania, United States of - - 2014
Evidence is conflicting with regards to the role of vitamin D in statin induced myalgia (SIM). Studies so far have assessed cross-sectional association and were limited by study sample selected predominantly from cardiology clinics. In this retrospective cohort study we assessed the association between vitamin D and SIM and attempted ...
Cormio Luigi L Department of Urology and Renal Transplantation, University of Foggia, Viale Luigi Pinto 1, 71121 Foggia, - - 2014
Objectives. Normal and neoplastic human tissues have different electromagnetic properties. This study aimed to determine the diagnostic accuracy of noninvasive electromagnetic detection of bladder cancer (BC) by the tissue-resonance interaction method (TRIM-prob). Patients and Methods. Consecutive patients were referred for cystoscopy because of (i) microscopic or gross hematuria and/or irritative ...
Paredi Paolo - - 2014
Determining the site of airways inflammation may lead to the targeting of therapy. Nitric oxide (NO) is a biomarker of airway inflammation and can be measured at multiple exhalation flow rates to allow partitioning into bronchial (large/central airway maximal nitric oxide flux [J'awno]) and peripheral (peripheral/small airway/alveolar nitric oxide concentration ...
Hassan Eman M EM Department of Endemic Medicine and Hepatology, Cairo University, Cairo, - - 2013
Gastroesophageal varices are present in approximately 50% of patients with liver cirrhosis. The aim of this study was to evaluate liver stiffness measurement (LSM), Fib-4, Forns Index and Lok Score as noninvasive predictors of esophageal varices (EV). This prospective study included 65 patients with HCV-related liver cirrhosis. All patients underwent ...
Puliyel Mammen M Children's Center for Cancer and Blood Diseases, Division of Hematology, Hospital Los Angeles, Los Angeles, CA, - - 2013
Ferritin levels and trends are widely used to manage iron overload and assess the efficacy of prescribed iron chelation in patients with transfusional iron loading. A retrospective cohort study was conducted in 134 patients with transfusion-dependent anemia, over a period of up to 9 years. To determine if the trends ...
Wuister Annemarie M H AM Department of Otorhinolaryngology and Head & Neck Surgery, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, The - - 2014
To assess the diagnostic value of nasal endoscopic findings in adults suspected of chronic rhinosinusitis. PubMed, EMBASE, and the Cochrane Library. A comprehensive search was performed up to March 5, 2013. Articles that assessed the diagnostic value of nasal endoscopy in adults suspected of chronic rhinosinusitis were included. For selected ...
Bohn Ethan - - 2013
Clinical outcomes of dialysis patients are variable, and improved knowledge of prognosis would inform decisions regarding patient management. We assessed the value of simple, chest X-ray derived measures of cardiac size (cardiothoracic ratio (CTR)) and vascular calcification (Aortic Arch Calcification (AAC)), in predicting death and improving multivariable prognostic models in ...
Park Ji Young - - 2013
The early identification of severe acute pancreatitis is important for the management and for improving outcomes. The bedside index for severity in acute pancreatitis (BISAP) has been considered as an accurate method for risk stratification in patients with acute pancreatitis. This study aimed to evaluate the comparative usefulness of the ...
Gebruers Nick N Department of Rehabilitation Sciences and Physiotherapy, Faculty of Medicine and Health Sciences, University of Antwerp, Universiteitsplein 1, 2610 Antwerp, Belgium. - - 2013
Few studies have investigated how well early activity measurements by accelerometers predict recovery after stroke. First, we assessed the predictive value of accelerometer-based measurements of upper-limb activity in patients with acute stroke with a hemiplegic arm. Second, we established the difference in arm activity between hospitalized stroke and nonstroke patients. ...
Schniepp Roman - - 2013
Falls are common in patients with cerebellar ataxia (CA). Identification of gait variables associated with a higher risk of falls allows us to detect fallers and initiate protective procedures early. Gait variability, which is increased in CA patients, is a good predictor of falls in elderly subjects and patients with ...
Yarur Andres J - - 2013
The wide use of abdomino-pelvic computed tomography (APCT) in emergency departments (ED) has raised the concern for radiation exposure, costs and potential reactions to contrast agents. The aim of this study was to determine the yield and predictive factors for clinically actionable findings (CAF) in APCTs performed in patients with ...
Kasai Y - - 2013
Background: Portal vein embolization (PVE) is considered to improve the safety of major hepatectomy. Various conditions might affect remnant liver hypertrophy after PVE. The aim of the present study was to clarify the factors that affect remnant liver hypertrophy and to establish a prediction formula for the hypertrophy ratio. Methods: ...
Lee Ho Yun - - 2013
We aimed to conduct a prospective, observational study of the applicability of EarCheck (Innovia Medical LLC, Omaha, NE) in the surgical management of chronic otitis media with effusion (COME). Between February 2013 and July 2013, 84 patients (165 ears) who had been diagnosed with COME and underwent surgical management were ...
Berdejo Javier - - 2013
-Two-dimensional (2D) echocardiography studies have shown that the maximum length of vegetation (MLV) ≥ 10 mm is a predictor of embolic events (EEs) in patients with infective endocarditis (IE). However, 2D measurements probably underestimate the vegetation dimensions. In this study we evaluate the feasibility of real-time three-dimensional transesophageal echocardiography (RT3DTEE) ...
Ham Nam Seok NS Nam Seok Ham, Jae Young Jang, Sung Woo Ryu, Ji Hye Kim, Eui Ju Park, Woong Cheul Lee, Kwang Yeun Shim, Soung Won Jeong, Hyun Gun Kim, Tae Hee Lee, Sung Ran Jeon, Jun Hyung Cho, Joo Young Cho, Institution for Digestive Research, Digestive Disease Center, Department of Internal Medicine, Soonchunhyang University Hospital, Seoul 140-743, South - - 2013
To determine whether magnified observation of short-segment Barrett's esophagus (BE) is useful for the detection of specialized intestinal metaplasia (SIM). Thirty patients with suspected short-segment BE underwent magnifying endoscopy up to × 80. The magnified images were analyzed with respect to their pit-patterns, which were simultaneously classified into five epithelial ...
Costa Luciano J - - 2013
It is unknown whether clinical characteristics can successfully predict which multiple myeloma (MM) patients would be poor mobilizers (PM) with growth factor (GF) alone so they can be assigned to mobilization with chemotherapy + GF or GF + plerixafor. MM patients (N=477) who underwent autologous mobilization with GF were retrospectively ...
van der Schee M P - - 2013
Exhaled breath contains disease-dependent volatile organic compounds (VOCs), which may serve as biomarkers distinguishing clinical phenotypes in asthma. Their measurement may be particularly beneficial in relation to treatment response. Our aim was to compare the performance of electronic nose (eNose) breath analysis with previously investigated techniques (sputum eosinophils, exhaled nitric ...
Nayak R R Department of Nephrology, Apollo Hospitals, Chennai, Tamil Nadu, - - 2013
We studied the accuracy of spot urine protein creatinine ratio (SpUr-PCR) to assess 24 h urine protein excretion (24 h-UP) in patients with chronic kidney disease (CKD). A total of 100 proteinuric CKD patients of stages 3 and 4 were studied. 24 h urine was collected to measure 24 h-UP ...
Coertjens Patrícia Chaves PC Federal University of Piauí, Parnaíba, - - 2013
To compare TLC and RV values obtained by the single-breath helium dilution (SBHD) method with those obtained by whole-body plethysmography (WBP) in patients with normal lung function, patients with obstructive lung disease (OLD), and patients with restrictive lung disease (RLD), varying in severity, and to devise equations to estimate the ...
Sinning Jan-Malte - - 2013
Aims: Acute kidney injury (AKI) is a strong but rather late predictor of mortality after transcatheter aortic valve implantation (TAVI). Early clinically useful markers for the detection of AKI and prediction of outcome are needed in order to control and improve management of periprocedural complications after TAVI. The aim of ...
Sang Gao - - 2013
Copeptin reflects the individual stress level, and is correlated with outcomes of critical illness. This study was designed to evaluate its relationship with disease severity, local complications, organ failure and mortality of severe acute pancreatitis (SAP). Seventy-eight SAP patients and 78 sex- and age- matched healthy individuals were recruited. Plasma ...
Bustamante Alejandro - - 2013
Chitotriosidase, a component of innate immunity, constitutes a sensitive parameter of macrophage activation and its elevated plasma activity reflects an inflammatory response. Given the deleterious effects of inflammation in brain ischemia, we aimed to assess the prognostic value of chitotriosidase activity in acute stroke patients. The study comprised 159 acute ...
Fenster Brett E - - 2013
Although the "3 beat rule" is widely utiized to discriminate patent foramen ovale (PFO)-mediated right-to-left shunt (RTLS) from intrapulmonary RTLS using saline contrast transthoracic echocardiography (SCE), SCE diagnostic performance has yet to be validated using an invasive intracardiac standard. Percutaneous PFO occluder placement was recently shown to ameliorate hypoxia in ...
Nemoto Takuya - - 2013
The purpose of this study was to determine if routine clinical measures can predict the presence and severity of ultrasound synovitis in rheumatoid arthritis (RA) patients. Bilateral 1-5 MCP (metacarpopharangeal) and wrist joints were examined using power Doppler (PD) ultrasound (US). Correlations between PD scores and routine clinical measures of ...
Nakao Jolene H JH Department of Emergency Medicine, St Luke's-Roosevelt Hospital Center, New York, NY, - - 2014
Jolt accentuation or exacerbation of a baseline headache with horizontal rotation of the neck is a physical finding believed to assess for meningeal irritation. We conducted a prospective observational study of neurologically intact emergency department (ED) patients undergoing lumbar puncture in 2 inner city academic EDs to validate the sensitivity ...
Wong Grace Lai-Hung - - 2013
CU-HCC score is accurate to predict hepatocellular carcinoma (HCC) in chronic hepatitis B (CHB) patients. However, diagnosis of cirrhosis may be incorrect based on ultrasonography, leading to some errors in HCC prediction. This study aimed to evaluate the accuracy of LSM-HCC score, refined from CU-HCC score with liver stiffness measurement ...
Chen Chien-Lin - - 2013
Abstract Objective. Ineffective esophageal motility is frequently found in patients with gastroesophageal reflux diseases. Secondary peristalsis contributes to esophageal acid clearance. Mosapride improves gastrointestinal (GI) motility by acting on 5-hydroxytrypatamine4 receptors. The authors aimed to evaluate the effect of mosapride on secondary peristalsis in patients with ineffective esophageal motility. Material ...
Wang Xianwei - - 2013
The CKD-EPI (Chronic Kidney Disease Epidemiology Collaboration) creatinine equation estimates glomerular filtration rate (GFR) more precisely than the MDRD (Modification of Diet in Renal Disease) Study equation. The risk implications of this equation have been compared with the MDRD Study equation in different demographic and clinical characteristics. However, whether a ...
Aatif Taoufiq T Department of Nephrology, Dialysis and Renal Transplantation, Mohammed V Military Hospital, Faculty of Medicine, Mohammed V-Souissi University, Rabat - - - 2014
Background: Quantification of hemodialysis became more accurate and easier after the advent of ionic dialysance and the use of methods for estimating urea distribution volume (V). The aim of this study was to compare different methods of hemodialysis dose assessment: Kt/VDau (Daugirdas 
2nd generation), Kt/VOCM (Kt by OCM (Online Clearance ...
Mejaddam Ali Y - - 2013
Heart rate complexity (HRC), commonly described as a "new vital sign," has shown promise in predicting injury severity, but its use in clinical practice has been precluded by the absence of real-time data. This study was conducted to evaluate the utility of real-time, automated, instantaneous, hand-held heart rate entropy analysis ...
Talbot Renée - - 2013
To evaluate the accuracy of the visual field index (VFI) for the Humphrey Visual Field Analyzer in a population of patients with mild to moderate glaucoma. Retrospective cohort study. The study included 42 patients (61 eyes) with at least 11 years of follow-up, and annual automated visual fields (VFs). Patients ...
Kumar Kirthi R KR Department of Pathology, Veterans Affairs North Texas Health Care System, TX, USA; The University of Texas Southwestern Medical Center, Dallas, TX, - - 2013
A causal relationship between oxyntic glands dilatation with protruding parietal cells, referred to as proton pump inhibitor (PPI) effects, and PPI use has been suspected but not established. We designed this study to evaluate the association between these changes and the use of PPIs and histamine2-receptor blockers (H2-blockers). We obtained ...
Melo Miguel - - 2013
Context:Thyroglobulin (Tg) levels measured at the time of remnant ablation after thyroid hormone withdrawal (THW) were shown to have prognostic value in predicting disease-free status.Objectives:To determine if stimulated Tg levels, measured at the time of remnant ablation performed under recombinant human TSH (rhTSH) stimulation, has value in predicting absence of ...
Pratt Arthur G - - 2013
Analyses of large clinical datasets from early arthritis cohorts permit the development of algorithms that may be used for outcome prediction in individual patients. The value added by routine use of musculoskeletal ultrasound (MSUS) in an early arthritis setting, as a component of such predictive algorithms, remains to be determined. ...
Kang Seok Hui - - 2013
Background: The aim of this study was to evaluate regression equations correcting estimated glomerular filtration rate (eGFR) and the clinical significance of the corrected eGFRs calculated using these equations. Patients and Methods: The authors determined how well corrected eGFR values calculated using regression equations predict residual renal function (RRF). Results: ...
Ciaccio Edward J - - 2013
When atrial fibrillation (AF) is incessant, imaging during a prolonged ventricular RR interval may improve image quality. It was hypothesized that long RR intervals could be predicted from preceding RR values. From the PhysioNet database, electrocardiogram RR intervals were obtained from 74 persistent AF patients. An RR interval lengthened by ...
Shin Hyun Wook - - 2013
The measurement of fecal elastas-1 in stools is a sensitive and relatively inexpensive noninvasive test. The aim of this study was to study fecal elastase levels in patients who develop pancreatic leakage after pancreaticoduodenectomy (PD) to determine if fecal elastase level can be used to predict patients at high risk ...
Hsu Jeremy Ming - - 2013
Military and civilian data would suggest that hemostatic resuscitation results in improved outcomes for exsanguinating patients. However, identification of those patients who are at risk of significant hemorrhage is not clearly defined. We attempted to identify factors that would predict the need for massive transfusion (MT) in an Australasian trauma ...
Rajappa M - - 2013
Systemic embolism is a serious and sometime fatal complication of rheumatic MS. We assessed the predictive power of D-Dimer level to predict occurrence of left atrial (LA) thrombi in patients with rheumatic mitral stenosis (MS). D-dimer levels were analyzed for 24 patients with rheumatic MS with LA clot and 22 ...
Chardoli Mojtaba M Sina Trauma and Surgery Research Center, Tehran University Medical Sciences, Tehran, Iran. - - 2013
As a significant number of patients diagnosed with transient ischemic attack (TIA) at emergency department are at risk to develop TIA or cerebral vascular accident (CVA), several attempts have been made to figure out a predictive method to detect those at higher risk of such attacks. We aimed to evaluate ...
Khojastepour Leila L Associated Professor, Department of Oral Radiology, School of Dentistry, Shiraz University of Medical Sciences, Shiraz, - - 2013
To report the association of pulp calcification with that of cardiovascular disease (CVD) using digital panoramic dental radiographs. Digital panoramic radiographs of patients referred from the angiography department were included if the patient was under 55 years old and had non-restored or minimally restored molars and canines. An oral and ...
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