Search Results
Results 351 - 400 of 5920
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Siemons Liseth - - 2012
OBJECTIVE: To evaluate the contribution of assessing forefoot joints to the measurement range and measurement precision of joint counts in early RA using item response theory. METHODS: Baseline measures of tender and swollen joint counts were analysed in 459 early RA patients from the DREAM remission induction cohort. The contribution ...
Treitel Michelle - - 2012
Background and Objective: Boceprevir is a novel inhibitor of the hepatitis C virus NS3 protease and was recently approved for the treatment of patients with chronic hepatitis C infection. The objective of this study was to evaluate the impact of impaired hepatic or renal function on boceprevir pharmacokinetics and safety/tolerability. ...
Villar Luisa M - - 2012
BACKGROUND: A clinically isolated syndrome (CIS) may be the initial presentation of multiple sclerosis (MS). However, some CIS never develop MS. The identification of patients at risk of MS conversion is crucial as early treatment may improve their outcome. Free kappa chains (FKC) are increased in cerebrospinal fluid (CSF) of ...
Incedayi Mehmet - - 2012
PURPOSE: The aim of this study was to characterize the frequency and location of left atrial diverticula by using multidetector computed tomography (MDCT). MATERIALS AND METHODS: Cardiac imaging was performed for 454 patients using 64-MDCT. Most patients were being examined for coronary artery disease. All images were interpreted by two ...
Sarkozy Andrea - - 2012
BACKGROUND: Consensus statements were proposed for the diagnosis of Brugada syndrome (BS). The clinical diagnostic criteria were defined as documented ventricular fibrillation or ventricular tachycardia (VT), family history of sudden cardiac death at <45years, diagnostic ECGs of family members, inducibility of VT during electrophysiological study, syncope or nocturnal agonal respiration. ...
Holmström Alexandra - - 2012
OBJECTIVES: Epidemiological studies of elderly heart failure (HF) patients (≥85years) are limited with inconsistent findings. Our objective is to confirm and extend epidemiological study in elderly (≥85years) patients using the Swedish Heart Failure Registry database. METHODS: This retrospective study included 8,347 HF patients aged ≤65years and 15,889 HF patients aged ...
Caruthers Regine L RL Department of Pharmacy, University of Michigan Hospitals and Health Centers, Ann Arbor, MI, - - 2013
Plastic bronchitis (PB) is a poorly understood disease that can complicate any underlying pulmonary disease. However, it appears to most often occur in patients with surgically palliated congenital heart disease, particularly after the Fontan procedure. Few data exist about the prevalence and etiology of PB in this population. In an ...
Yoshinaga Harumi H Department of Child Neurology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Japan. - - 2013
To clarify the clinical implications of the preceding positive spikes (PPSs) observed primarily in rolandic spikes, we analyzed PPSs in the rolandic and occipital spikes observed in the electroencephalograms (EEGs) of patients with two types of benign partial epilepsies (benign childhood epilepsy with centro-temporal spikes [BECT] and Panayiotopoulos syndrome [PS]) ...
Ishaq Muhammad - - 2012
OBJECTIVES: Our aim was to determine the frequency of restless leg syndrome (RLS) in rheumatoid arthritis (RA) patients from a low socioeconomic area of Pakistan and compare results with a control group to evaluate the effect of variables on RLS patients. METHODS: A clinical observational study was carried out on ...
Alsharif Abedallatif - - 2012
BACKGROUND: Complex regional pain syndrome (CRPS) is characterized by pain in combination with sensory, vasomotor, sudomotor, trophic and motor abnormalities. The diagnosis of CRPS is based primarily on clinical criteria and the presence of distinct signs and symptoms. The role of bone scintigraphy in the diagnosis of these patients has ...
Yamashita Hiroyuki - - 2012
Here, we present two Behçet's disease (BD) patients with an uncommon complication: inflammation surrounding the spinous processes revealed by positron emission tomography/computed tomography (PET/CT). Both patients were treated successfully with 20 mg of prednisolone daily. Whether BD should be considered a form of spondylarthritis remains an open question. However, inflammation around ...
Fabbri Elisa E Stroke Unit, Department of Internal Medicine, Aging and Nephrological Diseases, University of Bologna, 40138 Bologna, - - 2012
Celiac disease (CD) is frequently associated with neurological disorders, but very few reports concern the association with ischemic stroke. A 26-year-old woman affected by CD with secondary amenorrhea, carrier of a homozygous 5,10-methylenetetrahydrofolate reductase mutation with hyperhomocysteinemia, was affected by two occipital ischemic strokes within a period of 5 mo. ...
Neff Brian A - - 2012
OBJECTIVE: To compare presentations of Ménière's disease (MD), vestibular migraine (VM), and Ménière's disease plus vestibular migraine (MDVM), with and without comorbid chronic subjective dizziness (CSD). STUDY DESIGN: Retrospective review with diagnosis confirmed by consensus conference of investigators using published criteria for MD, VM, and CSD. SETTING: Ambulatory, tertiary dizziness ...
Kim Kyoung-Woon - - 2012
PURPOSE: This study was performed to determine the prevalence, type, and location of acetabular sulcus, which is known as a normal variant, by intraoperative observation in patients undergoing arthroplasty for a femoral neck or intertrochanteric fracture. METHODS: The study enrolled 98 patients (98 hips) (mean patient age, 79.1 years; age ...
Luk Ting-Hin - - 2012
Background: Exercise training improves endothelial function in patients with coronary artery disease (CAD) through unclear mechanisms. We hypothesized that mitochondrial dysfunction related to a lower habitual physical activity level (PAL) is associated with endothelial dysfunction. Methods and Results: We assessed habitual PAL by a validated International Physical Activity Questionnaire, brachial flow-mediated dilation ...
Aletaha Daniel - - 2012
BACKGROUND: Rheumatoid factor (RF) is prototypic for rheumatoid arthritis (RA) and serves diagnostic and prognostic purposes. RF is associated with joint destruction, but the role of disease activity as a potential mediator of these effects has not been clearly elucidated yet. OBJECTIVE: To investigate if higher radiographic progression (Sharp score, ...
Tan Eric W - - 2012
The need for accuracy in neurovascular examinations of the extremities of trauma patients is well recognized. The goals of this study were to (a) evaluate the completeness of orthopedic house staff documentation of the neurovascular status of adult patients with extremity trauma, (b) identify the frequency of individual element documentation, ...
Liu Li-Juan - - 2012
It still needs to be elucidated whether co-detection of EV71 with other intestinal tract viruses plays a role in the pathogenesis of severe hand-foot-mouth disease (HFMD). A total of 680 stool specimens collected from clinically diagnosed mild and severe-HFMD patients were tested for EV71, CA16, norovirus, bocavirus and rotavirus. The ...
Kasashima Yuko Y Department of Rehabilitation Medicine, Keio University School of Medicine, 35 Shinanomachi, Shinjuku, Tokyo 160-8582, Japan. - - 2012
Electroencephalogram-based brain-computer interface (BCI) has been developed as a new neurorehabilitative tool for patients with severe hemiparesis. However, its application has been limited because of difficulty detecting stable brain signals from the affected hemisphere. It has been reported that transcranial direct current stimulation (tDCS) can modulate event-related desynchronization (ERD) in ...
Irie Hidekazu - - 2012
PURPOSE: The objective was to examine whether baseline overweight/obesity influences the ARB, valsartan add-on effects on the cardio-cerebrovascular (CV) morbidity and mortality in the high-risk hypertensive patients who participated in the KYOTO HEART Study. METHODS AND RESULTS: The primary endpoint was the same as in the main study: a composite ...
Francque Sven - - 2012
BACKGROUND AND AIMS: Reliable non-invasive tools are needed for staging non-alcoholic fatty liver disease (NAFLD). Published scoring systems have not been validated in prospective assessments of unselected patients. We aimed to identify factors that predicted development of non-alcoholic steatohepatitis (NASH) in a large group of overweight or obese patients and ...
ErtaƟ Gökhan - - 2012
BACKGROUND: Chronic heart failure (CHF) is a major and growing public health problem resulting from the cardiac damage caused by a variety of disease processes. CHF has many comorbid conditions such as hypertension, coronary artery disease, peripheral artery disease and chronic kidney disease (CKD). Some of the chronic conditions may ...
Horstmann S - - 2012
BACKGROUND: Detecting paroxysmal atrial fibrillation (pAF) soon after acute cerebral ischaemia has a major impact on secondary stroke prevention. Recently, the STAF score, a composite of clinical and instrumental findings, was introduced to identify stroke patients at risk of pAF. We aimed to validate this score in an independent study ...
Markov Nickolay P - - 2012
OBJECTIVE: The purpose of this study was to examine the anatomic distribution and associated mortality of combat-related vascular injuries comparing them to a contemporary civilian standard. DESIGN: The Joint Trauma Theater Registry (JTTR) was queried to identify patients with major compressible arterial injury (CAI) and noncompressible arterial injury (NCAI) sites, ...
Shimamoto Yuko - - 2012
PURPOSE: Congestive heart failure (CHF) alters the pharmacokinetics of various drugs, including cardiovascular agents, due to decreased cardiac output and decreased renal blood flow. The purpose of this study was to evaluate the influence of CHF on the clearance of vancomycin, a glycopeptide antibacterial agent. METHODS: After reviewing more than ...
Kao Chih-Chin - - 2012
Hypertension is a frequent early manifestation of autosomal dominant polycystic kidney disease (ADPKD). Several mechanisms can cause hypertension in ADPKD patients, although, primary aldosteronism (PA) as a possible manifestation of hypertension in ADPKD is extremely rare. We retrospectively reviewed the Taiwan Primary Aldosteronism Investigation (TAIPAI) database, which listed a total ...
Zanoli Luca - - 2012
BACKGROUND AND AIMS:: Recent studies have reported early atherosclerosis in patients with inflammatory bowel disease (IBD). In these patients, the chronic low-grade inflammation may predispose to vascular remodelling and arterial stiffening. We aimed at studying arterial stiffness in IBD patients. METHODS:: Thirty-two IBD patients without cardiovascular risk factors and 32 ...
Pacini Stefania - - 2012
According to the World Health Organization, Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) is a neurological disease characterized by widespread inflammation and multi-systemic neuropathology. Aetiology and pathogenesis are unknown, and several agents have been proposed as causative agents or as factors perpetuating the syndrome. Exposure to heavy metals, with particular reference to ...
Lai Kuang-Chi - - 2013
The aim of this study was to identify predictors of treatment failure of percutaneous catheter drainage (PCD) in patients with hepatobiliary-pancreatic cancer with pyogenic liver abscess (PLA). Medical records of 44 patients with PLA with underlying hepatobiliary-pancreatic cancer who underwent PCD under computed tomographic guidance as primary treatment between January ...
Chen Yuemei - - 2012
BACKGROUND: Residual renal function (RRF) recently has been confirmed to be a significant predictor of morbidity and mortality in hemodialysis (HD) patients. As RRF is not exactly the same with 24-h residual urine volume, the aim of our study is to evaluate the association of residual urine volume with acute ...
Afsar Baris - - 2012
Increased evidence suggests that apart from patients with increased albumin excretion and decreased glomerular filtration rate (GFR); there are also patients with type 2 diabetes with decreased GFR but without albuminuria. The exact pathophysiologic mechanisms regarding these clinical conditions are not known. We suggest that different blood pressure (BP) levels ...
Houthuizen Patrick P Maastricht University Medical Center, Maastricht, - - 2012
Transcatheter aortic valve implantation (TAVI) is a novel therapy for treatment of severe aortic stenosis. Although 30% to 50% of patients develop new left bundle-branch block (LBBB), its effect on clinical outcome is unclear. Data were collected in a multicenter registry encompassing TAVI patients from 2005 until 2010. The all-cause ...
Whittemore Kenneth R KR - - 2012
OBJECTIVE: Described is a case series of clinical findings in children with persistent conductive or mixed hearing loss following tympanostomy tube placement for serous otitis media. STUDY DESIGN: Retrospective chart review. SETTING: Tertiary pediatric hospital. SUBJECTS/METHODS: Medical records of thirty-nine children who were referred for either conductive or mixed hearing ...
Chiang Chern-En - - 2012
BACKGROUND: -There is a paucity of international data on the various types of atrial fibrillation (AF) outside of the highly-selected populations from randomized trials. This study aimed to describe patient characteristics, risk factors, comorbidities, symptoms, management strategy, and control of different types of AF in real-life practice. METHODS AND RESULTS: ...
Shaw Dominick - - 2012
BACKGROUND: Most patients with asthma are managed exclusively in primary care. Little is known about the patterns of airway dysfunction in these patients and how these relate to other aspects of the disease. AIMS: We set out to assess this in a cross-sectional study of 262 patients. METHODS: Symptoms, spirometry, ...
Li Lifeng - - 2012
OBJECTIVES/HYPOTHESIS: To compare the aerodynamic differences around ostiomeatal complex between the convex side and concave side in patients with concurrent nasal septal deviation and chronic rhinosinusitis, and to explore the potential correlation between nasal septal deviation and chronic rhinosinusitis occurrence from the perspective aerodynamics. STUDY DESIGN: Retrospective case series. METHODS: ...
Asif Arif - - 2012
Cardiac implantable electronic device (CIED) leads can cause central venous stenosis (CVS). In addition, these devices can get infected. Both are critically important considerations in patients with chronic kidney disease (CKD) for at least two reasons: (i) central veins serve as the final pathway should these patients need an arteriovenous ...
Kobayashi A - - 2012
OBJECTIVES: Silent brain infarcts (SBI) are a common finding both in stroke-free patients and in patients after a cerebrovascular incident. They are considered a risk factor for subsequent symptomatic strokes. However, their influence on outcome in stroke patients treated with thrombolysis is not established. Our aim was to identify the ...
Ghobrial George M - - 2012
IntroductionGreater attention has been directed to endovascular recanalization of acute ischemic stroke in septuagenarians and above.TechniqueA retrospective chart review was conducted to include patients treated for acute ischemic stroke from 2006 to 2012. All patients underwent initial neurological assessment and non-contrast head CT. Patients treated from 2009 to 2012 additionally ...
Palaniyappan Lena - - 2012
BACKGROUND: Several studies have found widespread structural changes affecting the grey matter at various stages of schizophrenia (the prodrome, first-episode, and the chronic stage). It is unclear which of these neuroanatomical changes are associated with a predisposition or vulnerability to develop schizophrenia rather than the appearance of the clinical features ...
Haq Muhammad M - - 2012
AIM: The objective of this study was to determine the frequency of clinically overt hepatic encephalopathy (HE) in cirrhotic patients undergoing diagnostic or therapeutic upper gastrointestinal endoscopy (UGE) who received midazolam for sedation. METHODS: This was an interventional study carried out at Liaquat National Hospital, Karachi. Consecutive patients presenting to ...
Anderson William J - - 2012
ABSTRACT BACKGROUND: Chronic obstructive pulmonary disease (COPD) is associated with significant cardiovascular mortality. Left ventricular hypertrophy (LVH) is a pivotal cardiovascular risk factor. The prevalence of LVH in COPD is currently unknown. METHODS: We performed a pilot study of 93 normoxaemic COPD patients and 34 controls. Patients underwent echocardiography to ...
Attar Alain - - 2012
Abstract Objective. The Glasgow-Blatchford score (GBS) has been validated to select severe patients with non-variceal upper gastrointestinal hemorrhage (UGIH). The aim was to compare the yield of the triage based on the GBS with an endoscopist' decision to perform an urgent upper gastrointestinal endoscopy (UGIE) in newly admitted patients and ...
Fujita Shinya - - 2012
Some thrombopoietin receptor-agonists (TPR-As) have been developed and shown to be highly effective in the treatment of immune thrombocytopenic purpura (ITP). Soluble cytotoxic T-lymphocyte-associated antigen 4 (sCTLA-4) can modulate and terminate the immune response. Several reports have shown that sCTLA-4 levels are elevated in patients with some autoimmune disorders. However, ...
Trevisani Franco - - 2012
BACKGROUND & AIMS: QT interval prolongation is frequent in cirrhosis, and stressful conditions could further prolong QT. We aimed to test this hypothesis and, if it proved correct, to assess its prognostic meaning. METHODS: We reviewed the clinical records of 70 consecutive cirrhotic and 40 non-cirrhotic patients with acute gastrointestinal ...
Decalmer Samantha - - 2012
ABSTRACT BACKGROUND: Micro-aspiration is often considered a potential cause of cough. The aim of this study was to investigate the relationship between micro-aspiration, the degree and type of gastro-oesophageal reflux, and the frequency of coughing in patients with chronic cough. METHODS: 100 chronic cough patients [mean age 55.8yrs (±11.0); 65 ...
Karakas Elias - - 2012
BACKGROUND: Cure of parathyroid carcinoma (PC) requires initial en bloc resection, including resection of all tumor-bearing tissue, with hemithyroidectomy and dissection of the central lymph node compartment. Unfortunately, no reliable preoperative criteria have yet been assessed to indicate a high likelihood of PC. Thus, the aim of the present study ...
Chao Pei-Wen - - 2012
BACKGROUND: Acute appendicitis in patients with end-stage renal disease (ESRD) poses a diagnostic challenge. Delayed surgery can contribute to higher morbidity and mortality rates. However, few studies have evaluated this disease among ESRD patients. Our study focused on the lack of data on the incidence and risk factors of acute ...
Silva Isabel Cristina Medeiros - - 2012
Background: Upper aerodigestive symptoms (UADS) have been reported by patients who have had thyroidectomies. This study evaluated the long-term prevalence of UADS after thyroidectomy in patients who did and who did not have intraoperative neuromonitoring (IONM). Methods: This was a cross-sectional study of patients with normal vocal fold mobility who ...
Weijs B - - 2012
AIMS: Idiopathic atrial fibrillation (AF) may be an expression of as yet undetected underlying heart disease. We found it useful for clinical practice to study the long-term development of cardiovascular disease (CVD) in patients diagnosed with idiopathic AF.METHODS AND RESULTS: Forty-one consecutive idiopathic AF patients (56 ± 10 years, 66% ...
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