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Results 201 - 250 of 5924
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Reininghaus Eva - - 2012
ABSTRACT: Huntington's disease (HD) and multiple sclerosis (MS) are both chronic progressive illnesses posing a serious challenge to affected patients and families. Sexual dysfunction in HD as well as in MS is a very common problem, although it is unclear whether the dysfunction is caused by the chronic illness itself ...
Ding Dale - - 2012
: The appropriate management of unruptured arteriovenous malformations (AVMs) remains the subject of controversy. In the present study, we evaluate the radiographic and clinical outcomes of Gamma Knife Radiosurgery (GKRS) for a large cohort of patients with unruptured AVMs. : From a prospective database of 1204 AVM patients treated with ...
Ding Zhen - - 2012
OBJECTIVE: This study was performed to determine the prevalence of chronic kidney disease (CKD) as well as its association with mid-term prognosis in patients with stable premature coronary artery disease (CAD) in a Chinese population. METHODS: Five hundred and twelve patients from Jiangsu Province, China with stable, premature CAD were ...
Sommer Sebastian-Patrick - - 2012
Objectives: a history of myeloproliferative neoplasms is considered to increase the risks in cardiac surgery. In patients with myeloproliferative neoplasms, increased rates of perioperative infections and thromboembolic complications are suspected, but studies analyzing the impact of myeloproliferative neoplasms on results after cardiac surgery are lacking. Methods: 13 patients with the ...
Kulwin Charles Glen - - 2012
: The management of patients with symptoms of tethered cord syndrome (TCS) who lack significant radiographic abnormalities is controversial (1,2,3). One potential marker for TCS is syringomyelia (4,5). However, a syrinx may be a benign and incidental finding (6,7). We evaluate a highly selected cohort of patients who had symptoms ...
Limper Maarten - - 2012
OBJECTIVE: To evaluate whether markers of the acute-phase response in patients presenting with arthralgia and positive anticitrullinated protein antibodies (ACPA) and/or immunoglobulin M rheumatoid factor (IgM-RF) could be predictive for the development of arthritis. METHODS: In total, 137 ACPA- and/or IgM-RF-positive patients were included. Patients were followed annually for the ...
Cerase A - - 2012
Transient ischemic attack (TIA) has to be considered an "alarm bell" of a more or less severe organic or systemic vasculopathy. Positive findings at neuroimaging means tissue damage. The purpose of this retrospective study was to assess the role of neuroimaging in the management of patients presenting with TIA, and ...
Liu Xiuli - - 2012
Long-standing inflammatory bowel disease (IBD), either ulcerative colitis or Crohn disease, is associated with a high risk of developing colorectal adenocarcinoma (CAC). However, histomorphology of IBD-associated CAC has not been thoroughly examined, and it is unclear whether and how these patients should be screened for Lynch syndrome (LS). We evaluated ...
Alfonso Fernando - - 2012
This prospective study sought to assess the diagnostic value of optical coherence tomography (OCT) compared with intravascular ultrasound (IVUS) in patients presenting with stent thrombosis (ST). Although the role of IVUS in this setting has been described, the potential diagnostic value of OCT in patients suffering ST remains poorly defined. ...
Messerschmidt Kimberly A - - 2012
Purpose The case of a patient with Parkinson's disease (PD) who experienced profound encephalopathy after short-term exposure to metoclopramide is described. Summary A 79-year-old man with PD received metoclopramide (10 mg i.v. every six hours) for stimulation of gastric motility after a colon resection; the first of three doses of ...
Turak Osman - - 2012
Inflammation plays a crucial role in the pathogenesis of in-stent restenosis (ISR). Neutrophil-to-lymphocyte ratio (NLR) provides a simple method for assessment of inflammatory status and prognosis in patients with coronary artery disease. The aim of the present study was to investigate the predictive value of preprocedural NLR on development of ...
Zamproni Laura Nicoleti - - 2012
Patent foramen ovale is associated with paradoxical embolism (PE) and stroke. Hypercoagulable states, such as antiphospholipid syndrome (APS), can exacerbate PE by increasing clot formation. The aim of this study was to verify whether patients with APS and stroke present a right-to-left shunt (RLS) with greater frequency than patients with ...
Fratini Federica - - 2012
OBJECTIVE:Screening plasma samples from patients with sporadic Creutzfeldt-Jakob disease (CJD) to discover diagnostic biomarkers. METHODS:Plasma samples were collected from 17 patients with sporadic CJD, 17 patients with Alzheimer disease (AD), and 20 healthy subjects. A 2-phase screening was carried out using quantitative protein mass spectrometry. The putative sporadic CJD biomarkers ...
Zhang Xiang Yang - - 2012
Schizophrenia shows gender differences in patients' clinical presentation, neurocognitive impairment, course, and treatment outcome. The aims of this study were to compare gender differences in clinical features and cognitive functioning in first-episode and chronic schizophrenia among Han Chinese inpatients. We compared gender differences in 262 unmedicated first-episode schizophrenia and 960 ...
Tsuji Takayuki - - 2012
Since cardiac sarcoidosis (CS) leads to substantial morbidity and sudden death, early diagnosis and appropriate management are crucial for patients with CS. Echocardiography used to be considered a useful diagnostic tool for patients with CS, but CS may clinically present as dilated cardiomyopathy (DCM). Our objective was to investigate whether ...
Nery-Fernandes Fabiana - - 2012
BACKGROUND: Impulsivity is a characteristic of bipolar disorder (BD) that can contribute to the risk for suicidal behavior. Evidence suggests that gray and white matter abnormalities are linked with impulsivity, but little is known about the association between corpus callosum (CC) and impulsivity in BD. We examined the CC area ...
Vij Alok - - 2012
Background  The most common types of cutaneous T cell lymphoma (CTCL) are mycosis fungoides (MF) and its leukemic variant, Sézary syndrome (SS). One of the hallmarks of MF and SS is pruritus that rarely responds to treatment. Little is known about the prevalence and severity of pruritus in MF and ...
Amitrano Lucio - - 2012
: Hypoxic hepatitis (HH) occurring after gastrointestinal bleeding in cirrhotic patients has been scarcely studied and is reported as a rare occurrence carrying a severe prognosis. The management of bleeding from esophageal varices (BEV) and similarly the prognosis has improved in the last decades. : To evaluate retrospectively the incidence, ...
Konishi Masanori - - 2012
Although hyponatremia during hospitalization for acute decompensated heart failure (ADHF) has been reported to correlate with poor prognosis, few studies have examined the effect of progression of hyponatremia on cardiac prognosis in ADHF patients who were normonatremic at admission. Consecutive ADHF patients (n = 662) categorized as New York Heart Association Class ...
Dallaire Frédéric - - 2012
The long-term risk of patients with Kawasaki disease is not well defined. A great proportion of patients with Kawasaki disease have important variation of their coronary artery (CA) diameters, but the significance of this variation is not known. The aim of this study was to test the hypothesis that patients ...
Clemmens Clarice - - 2012
OBJECTIVE: To evaluate epidemiologic differences between patients with unilateral and bilateral Ménière's disease (MD). To evaluate these differences for insights into the possible causes of bilateral MD. BACKGROUND: The diagnosis of MD is based on clinical criteria, and its cause is unknown. Differences in characteristics of patients with unilateral and ...
Eikelboom John W - - 2012
Apixaban is superior to aspirin for the prevention of stroke in patients with atrial fibrillation. Apixaban is partially renally excreted and may accumulate in patients with renal impairment. We evaluated the efficacy and safety of apixaban 5 mg twice daily (2.5 mg twice daily in selected patients) compared with aspirin ...
Biagi Federico - - 2012
Gastrointestinal manifestations and villous atrophy can be seen in patients with common variable immunodeficiency (CVID). In some patients, infectious agents may be responsible, whereas in others, celiac disease (CD) may be the cause. In this study, we investigate the causes and the histopathologic features seen in patients with CVID. Eleven ...
Sanmartí Raimon - - 2012
OBJECTIVE: To analyze longterm progression to rheumatoid arthritis (RA) and the predictive value of anticitrullinated peptide/protein antibodies (ACPA) in palindromic rheumatism (PR). METHODS: We selected all patients in our clinic with PR who had at least 1 ACPA measurement. We included only patients with pure PR, defined as no evidence ...
Zhang Li Yun - - 2012
Introduction: Few ultrastructural studies have been reported in psoriatic arthritis (PsA). The authors report a series of synovial biopsies with emphasis on patients with early disease to look for distinctive light (LM) and electron microscopic (EM) features of possible importance. Methods: The authors examined synovial biopsies obtained primarily by needle ...
Ulusoy Sukru - - 2012
BACKGROUND: Signal peptide-CUB (complement C1r/C1s, Uegf, and Bmp1)-EGF (epidermal growth factor)-domain-containing protein 1 (SCUBE1) is a cell surface protein belonging to the SCUBE gene family. SCUBE1 has been shown to rise in parallel with platelet activation in acute ischemic events. However, there are no studies showing levels in the hemodialysis ...
Patel Virendra I - - 2012
OBJECTIVE: Chronic kidney disease (CKD) is associated with increased morbidity and death after open abdominal aortic aneurysm (AAA) repair (OAR). This study highlights the effect of CKD on outcomes after endovascular AAA (EVAR) and OAR in contemporary practice. METHODS: The National Surgical Quality Improvement Program (NSQIP) Participant Use File (2005-2008) ...
Pérez Yenly G - - 2012
Systemic lupus erythematosus (SLE) is an autoimmune disease of unknown origin associated with oxidative stress. The present study aimed to investigate the presence of oxidative stress in patients with newly diagnosed SLE. SLE patients (n = 36) and control subjects (n = 28) were enrolled in this study. Blood samples ...
Merchea Amit - - 2012
: Patients with chronic ulcerative colitis are at increased risk of developing colorectal cancer. Limited data exists in ulcerative colitis patients with rectal cancer regarding clinical and oncologic outcomes, and the ideal operative approach. : To describe our experience in the management of patients with rectal cancer in the setting ...
Sun Xiaoyan - - 2012
Background: Although an association between the apolipoprotein E (APOE) ∈4 allele and increased risk of Alzheimer's disease (AD) is established, the utility of APOE genotyping in the clinical diagnosis of AD is still under investigation. Methods: Medical records of 89 patients with cognitive impairment and APOE genotype data underwent a ...
Clemente Gleice - - 2012
OBJECTIVE: To assess the frequency of calcinosis in patients with juvenile dermatomyositis, and the possible risk factors for that manifestation. METHODS: Medical record review of 34 patients, with an emphasis on the following characteristics: demographic, clinical and laboratory data; type of treatment; adherence to treatment; disease course (monocyclic, chronic and ...
Hochman Mark N - - 2012
The purpose of this research was to quantify the visual display (presence) or lack of display (absence) of interdental papillae during maximum smiling in a patient population aged 10 to 89 years. Four hundred twenty digital single-lens reflex photographs of patients were taken and examined for the visual display of ...
Contoli M - - 2012
The role of small airway abnormalities in asthma pathogenesis has been extensively studied and debated for several decades. However, whether or not small airway abnormalities play a relevant role in specific phenotypes of asthmatic patients and contribute to clinical presentation is largely unknown. In the present review, we evaluated available ...
Bytzer P - - 2012
Although most patients with gastro-oesophageal reflux disease (GERD) benefit from proton pump inhibitor (PPI) therapy, some experience only partial symptom relief. To determine the prevalence of partial heartburn response to PPIs and its impact on health-related quality of life. Four randomised, double-blind studies in adults with reflux disease compared esomeprazole ...
Tolin David F - - 2012
Hoarding disorder (HD), previously considered a subtype of obsessive-compulsive disorder (OCD), has been proposed as a unique diagnostic entity in DSM-5. Current models of HD emphasize problems of decision-making, attachment to possessions, and poor insight, whereas previous neuroimaging studies have suggested abnormalities in frontal brain regions. To examine the neural ...
Qi Xingshun - - 2012
The presence of occlusive portal vein thrombosis (PVT) greatly changes the natural history of liver cirrhosis, because it not only significantly increases the incidence of variceal rebleeding but also negatively influences the survival. However, due to the absence of strong evidence, no standard treatment algorithm for the secondary prophylaxis of ...
Liu L-L - - 2012
Complement system activation is associated with immunoglobulin A nephropathy (IgAN) activity and progression. The aim of the present study was to investigate the importance of urinary mannose-binding lectin (MBL), at the time of renal biopsy, for evaluating disease severity and predicting the progression of IgAN. A total of 162 patients ...
Holstein Joerg H - - 2012
Our knowledge of factors influencing mortality of patients with pelvic ring injuries and the impact of associated injuries is currently based on limited information. We identified the (1) causes and time of death, (2) demography, and (3) pattern and severity of injuries in patients with pelvic ring fractures who did ...
Gitchel George T - - 2012
To further assess oculomotor control of patients with Parkinson disease (PD) during fixation and with movement. Case-control study. A Parkinson disease research, education, and clinical center. PATIENTS One hundred twelve patients with PD, including 18 de novo untreated patients, and 60 age-matched controls. Modern, precise eye tracking technology was used ...
Lavergne Valery - - 2012
Widespread Al toxicity is unusual today. In 2005, Canadian peritoneal dialysis (PD) centers reported widespread hyperaluminemia in patients using dialysates from one specific manufacturer. Our objectives were to evaluate risk factors related to Al accumulation and to assess its clinical consequences in patients from 2 centers. A retrospective closed cohort ...
Pang Wing-Fai WF Department of Medicine, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, Hong Kong SAR, PR - - 2013
Studies in hemodialysis patients suggest that the "surprise" question can help to identify a group of patients with a high mortality risk who should receive priority for palliative care interventions. However, the same instrument has not been tested in peritoneal dialysis (PD) patients. We studied 367 prevalent PD patients from ...
Park Jung Tak JT Department of Internal Medicine, College of Medicine, Brain Korea 21 for Medical Science, Severance Biomedical Science Institute, Yonsei University, Seoul, - - 2013
The leptin/adiponectin (L/A) ratio has been suggested to be an atherosclerotic index for diabetic patients and a useful marker of insulin resistance in patients with and without diabetes. Even though end-stage renal disease (ESRD) patients on peritoneal dialysis (PD) are well characterized by abnormal adipocytokine metabolism, the significance of alterations ...
Arif Ambreen A Pakistan Medical Research Centre, Jinnah Postgraduate Medical Centre, Rafique Shaheed Road, Karachi. - - 2012
To quantify liver damage using Metavir score, in chronic hepatitis C patients having normal alanine aminotransferase (ALT) to determine active disease requiring treatment. An analytical study. Pakistan Medical Research Centre, JPMC, Karachi, from January 2007 - December 2010. Patients suffering from hepatitis C with positive PCR, having persistently normal ALT ...
Abraham Bincy P BP Michael E. DeBakey Veterans Affairs Medical Center, Baylor College of Medicine, Texas Children's Hospital, Houston, TX, USA. - - 2012
There has been no systematic review of natural history studies of pediatric-onset inflammatory bowel disease (IBD). We conducted a systematic review focused on understanding the long-term risks of growth failure, disease reclassification and extension, hospitalizations, cancer and death among patients with childhood IBD. PubMed searches and subsequent data abstraction were ...
Gorugantula Lakshmi Mitreyi LM Department of Biomedical Sciences, Texas A&M Health Science Center-Baylor College of Dentistry, Dallas, Texas 75246, - - 2012
The objective of this study was to gather preliminary data concerning the feasibility of using salivary basic fibroblast growth factor (bFGF) for detecting development of oral squamous cell carcinoma (OSCC) in patients with oral lichen planus (OLP), and in patients with OSCC whose disease was in remission. Saliva samples were ...
Kinoshita Yoshikazu - - 2012
BACKGROUND: The clinical characteristics of Japanese patients with eosinophilic esophagitis (EoE) and eosinophilic gastroenteritis (EGE) have not been fully clarified. For understanding the pathogenesis as well as providing support for accurate diagnosis, precise information regarding clinical characteristics of these diseases is important. METHODS: A questionnaire-based survey of EoE and EGE ...
Alvarez Vincent - - 2012
OBJECTIVES: To analyze the prevalence of stimulus-induced rhythmic, periodic or ictal discharges (SIRPIDs) in patients with coma after cardiac arrest (CA) and therapeutic hypothermia (TH) and to examine their potential association with outcome. METHODS: We studied our prospective cohort of adult survivors of CA treated with TH, assessing SIRPIDs occurrence ...
Middeke Jan M - - 2012
The European LeukemiaNet classification combines a heterogeneous group of aberrations as high risk (HR) abnormalities. Our goal was to investigate the outcomes associated with distinct high-risk chromosomal abnormalities in acute myeloid leukemia (AML) after allogeneic hematopoietic stem-cell transplantation (HSCT). We performed a retrospective cohort analysis in patients with HR AML ...
Ishikawa Takuya - - 2012
Background and Aim:  Although peripancreatic vascular lesions are occasionally encountered in autoimmune pancreatitis (AIP), there are few reports focusing on these involvements. We aimed to investigate the peripancreatic vascular involvements associated with AIP. Methods:  We retrospectively analyzed 54 AIP patients who met the International Consensus Diagnostic Criteria for AIP between ...
Nadkarni Nikhil - - 2012
Background:  The cardiac changes in acute pancreatitis have been earlier studied but the data on their prognostic significance is limited. This study was done to determine electrocardiographic (ECG) & echocardiographic changes in acute pancreatitis & determine their prognostic significance. Patients & Methods:  Fifty-two consecutive patients (mean age 36.5 ± 11 ...
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