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Tantawy Azza Abdel Gawad - - 2012
CD163 is expressed on cells of monocyte-macrophage lineage and is the main hemoglobin-haptoglobin receptor. Inflammation and monocyte activation are predisposing factors to vaso-occlusion and pulmonary hypertension, which are serious complications in sickle cell disease (SCD). Siblings of SCD patients may have the same pathophysiology without displaying symptoms. We assessed soluble ...
Leber B - - 2012
Background/objectives:Obesity and metabolic disorders are linked to inflammation via gut microbiota and/or gut permeability. Gut-derived endotoxin triggers inflammation leading to metabolic syndrome (MetS) and contributing to oxidative stress. We intended to investigate the effect of Lactobacillus casei Shirota on gut permeability, presence of endotoxin and neutrophil function in MetS.Subjects/methods:Patients with ...
Lin Hung-Sheng - - 2012
BACKGROUND: We hypothesized that serum level of neopterin is significantly predictive of prognostic outcome in patients after acute ischemic stroke (IS). METHODS: Between November 2008 and May 2010, serum levels of neopterin were prospectively collected at 48h after acute IS in 157 patients. RESULTS: Serum neopterin levels were substantially higher ...
Sha Sharon J SJ Department of Neurology, University of California, San Francisco, USA. - - 2012
To describe the phenotype of patients with C9FTD/ALS (C9ORF72) hexanucleotide repeat expansion. A total of 648 patients with frontotemporal dementia (FTD)-related clinical diagnoses and Alzheimer disease (AD) dementia were tested for C9ORF72 expansion and 31 carried expanded repeats (C9+). Clinical and neuroimaging data were compared between C9+ (15 behavioral variant ...
Gruner Patricia P Center for Psychiatric Neuroscience, Feinstein Institute for Medical Research, Manhasset, NY, USA. - - 2012
Obsessive-compulsive disorder (OCD) is a prevalent and often severely disabling illness with onset generally in childhood or adolescence. Although white matter deficits have been implicated in the neurobiology of OCD, few studies have been conducted in pediatric patients when the brain is still developing and have examined their functional correlates. ...
Rutherford Anna A Department of Internal Medicine, Brigham & Women's Hospital, Boston, MA 02114, - - 2012
Patients with acute liver failure (ALF) have high mortality and frequently require liver transplantation (LT); few reliable prognostic markers are available. Levels of M30, a cleavage product of cytokeratin-18 caspase, are significantly increased in serum samples from patients with ALF who die or undergo LT. We developed a prognostic index ...
Macdonald Jamie H - - 2012
BACKGROUND: Fatigue is one of the most prevalent symptoms in chronic kidney disease (CKD). However, fatigue mechanisms are poorly understood due in part to nonspecific definitions. This study investigates exertional fatigue during simulated activities of daily living, focusing on oxygen delivery and utilization. STUDY DESIGN: "Explanatory" matched-cohort study. PARTICIPANTS & ...
Solak Yalcin - - 2012
Colchicine has been used in a number of disorders. Because colchicine is partially excreted from the kidney, there is a need for dose reduction in case of renal functional impairment. There are no data with regards to safe dosing schedule of colchicine in hemodialysis patients. We aimed to evaluate adverse ...
Weijs B - - 2012
OBJECTIVE: Idiopathic atrial fibrillation (AF) refers to a clinically lacking cardiovascular or pulmonary disease generating the pathophysiological substrate for the arrhythmia. However, since idiopathic AF is associated with an increased event rate, it could be a harbinger of as yet undetected underlying heart disease. We studied the prevalence of coronary ...
Invernizzi Marco - - 2012
BackgroundNormocalcemic Primary Hyperparathyroidism (PHPT-N) is a condition which may have similar long-term implications than Primary Hyperparathyroidism (PHPT); however parathyroids disorders differential diagnosis and treatment are not clearly defined. We investigated the effect of an oral peptone and an oralcalcium load on calcium-regulating hormones in PHPT-N compared to PHPT and healthy ...
Rizos Timolaos - - 2012
Cardioembolism in paroxysmal atrial fibrillation (pxAF) is a frequent cause of ischemic stroke. Sensitive detection of pxAF after stroke is crucial for adequate secondary stroke prevention; the optimal diagnostic modality to detect pxAF on stroke units is unknown. We compared 24-hour Holter electrocardiography (ECG) with continuous stroke unit ECG monitoring ...
Gebhard Catherine - - 2012
BACKGROUND: Left ventricular noncompaction (LVNC) is characterized by a two-layered myocardium consisting of a noncompacted inner and a compacted outer layer. The ratio of the thicknesses of these two layers is a major diagnostic criterion, which is, however, often difficult to apply in clinical practice. METHODS: Transthoracic echocardiography was performed in ...
Liu Song - - 2012
GOALS:: This study was designed to investigate the clinical features of nonthyroidal illness syndrome (NTIS) compared with euthyroid patients in Crohn's disease (CD), to explore the etiology of NTIS in CD, to evaluate the clinical outcomes of NTIS patients, and to inspect the correlation of clinical variables and NTIS, and ...
Terao Yasuo - - 2012
OBJECTIVE: To investigate horizontal saccade changes according to disease stage in patients with progressive supranuclear palsy (PSP). METHODS: We studied visually and memory guided saccades (VGS and MGS) in 36 PSP patients at various disease stages, and compared results with those in 66 Parkinson's disease (PD) patients and 58 age-matched ...
Llamas-Velasco M - - 2012
INTRODUCTION: Neutrophilic urticaria, described by Winkelmann in 1985, has yet to be completely defined and its clinical significance is poorly understood. Nevertheless, recent publications suggest that it could be a marker for rheumatic disease. The primary objective of this study was to compare the prevalence of rheumatic disease in 2 ...
Han Jung-Yeon - - 2012
The aim of this study was to determine the association of mean platelet volume (MPV) with the development of stroke or coronary artery disease (CAD) in diabetes mellitus (DM). MPV was analyzed in 200 Korean patients with DM. The primary endpoint was composite of ischemic stroke/CAD events. The mean MPV ...
Mendez Mario F - - 2012
Early-onset Alzheimer's disease (EOAD) beginning before the age of 65 may differ from late-onset AD (LOAD) in clinical course and frequency of nonamnestic presentations. In a 10-year retrospective review, 125 patients with EOAD, diagnosed clinically and verified by functional neuroimaging, were compared with 56 patients with LOAD and further classified ...
Malaquias Alexsandra C - - 2012
Noonan syndrome (NS) and Noonan-like syndromes (NLS) are autosomal dominant disorders caused by heterozygous mutations in genes of the RAS/MAPK pathway. The aim of the study was to construct specific growth charts for patients with NS and NLS. Anthropometric measurements (mean of 4.3 measurements per patient) were obtained in a ...
Nizon Mathilde - - 2012
Catel-Manzke syndrome is characterized by hyperphalangism with bilateral deviation of the index fingers and micrognathia with or without cleft palate. Some atypical patients present with additional malformations. No molecular basis is yet available. Most patients have an unremarkable family history but autosomal recessive inheritance has been recently suggested in a ...
Corporaal Sharissa H A - - 2012
OBJECTIVE: To investigate which measures of trunk sway taken during stance and gait tasks are best correlated with Expanded Disability Status Scale (EDSS) scores of multiple sclerosis (MS) patients. METHODS: We studied 37 MS patients (mean age 43±10 years; 76% female; 81% relapsing-remitting MS; mean EDSS score 2.8±1.1). The study ...
Masuda Masatsugu - - 2012
HYPOTHESIS: We investigated whether inflammatory biomarkers and stress are involved in the pathophysiology of idiopathic sensorineural hearing loss (ISHL). STUDY DESIGN: Individual cohort study. SETTING: Two tertiary centers. PATIENTS: Forty-three ISHL and 10 non-ISHL patients seen in our ENT departments from 2004 to 2010 within a week from the onset ...
Nadaraja Garani Shiranthana - - 2012
OBJECTIVE: To determine a radiographic association between superior semicircular canal dehiscence (SSCD) and tegmen dehiscence (TD). STUDY DESIGN: Retrospective case-control series. SETTING: Tertiary referral center. PATIENTS: Patients seen between 2003 and 2010 with radiographic SSCD were compared with cochlear implant recipient controls. INTERVENTION: The tegmen and superior semicircular canal were ...
Lee You-Hyun - - 2012
The objective of this study is to investigate the value of multidetector computed tomography (MDCT) in the assessment of sacroiliitis in patients with established ankylosing spondylitis (AS). Paired plain radiographs and MDCT images of the 330 sacroiliac (SI) joints in 165 patients with definite or probable ankylosing spondylitis were analyzed ...
Alhamad Esam H - - 2012
OBJECTIVE: To determine the clinical characteristics and outcomes of patients with lungdominant connective tissue disease (LD-CTD) with a usual interstitial pneumonia (UIP) who do not meet the criteria for any form of CTD, and to compare these parameters with those of patients with idiopathic pulmonary fibrosis (IPF/UIP) and CTD-associated-UIP. METHODS: ...
Beirão Nuno M - - 2012
Purpose: Familial amyloidosis with polyneuropathy (FAP) sometimes courses with vitreous amyloid. The aim of this study was to evaluate the incidence of glaucoma after vitrectomy in FAP patients. Methods: A total of 79 eyes of 42 liver transplanted FAP patients and 16 eyes of 16 non-FAP patients with rhegmatogenous retina ...
Schuller-Petrovic S - - 2012
Leg telangiectasias resistant to repeated courses of sclerotherapy in patients without deep and superficial venous incompetence are not uncommon. Little is known about factors which may underlie the resistance. Among 26 patients with such telangiectasias we found a direct communication of the vessels with deep and saphenous veins in 65% ...
Eckstein Jens - - 2012
OBJECTIVES: Due to different release mechanisms, mid-regional pro-atrial natriuretic peptide (MR proANP) may be superior to N-terminal pro-B-type natriuretic peptide (NT proBNP) in the diagnosis of acute heart failure (AHF) in patients with atrial fibrillation (AF). We compared MR proANP and NT proBNP for their diagnostic value in patients with ...
Farag Fawzy F - - 2012
This study evaluates the outcome of trials to stimulate the dorsal genital nerve (DGN) in patients with lower urinary tract dysfunction. The aim of most studies was to suppress detrusor overactivity in patients with overactive bladder (OAB) syndrome by DGN stimulation. A literature search was performed using Pub Med, Web ...
Agrawal Ashish - - 2012
Plasma and bronchoalveolar lavage (BAL) biomarkers related to the pathogenesis of acute lung injury (ALI) have previously been associated with poorer clinical outcomes and increased disease severity among patients with ALI. Whether these biomarkers have predictive value in a less severely ill population that excludes septic patients with high APACHE ...
Cho Bang-Hoon - - 2012
BACKGROUND: Microalbuminuria is thought to be independently associated with an increased risk of, and mortality from, stroke. However, no studies have shown whether microalbuminuria is associated with the early clinical outcomes of acute ischaemic stroke. Therefore we investigated whether this. We also looked at radiological outcomes in stroke patients with ...
Zhang H - - 2012
BACKGROUND AND PURPOSE:Decreased oxygen supply may cause neuronal damage in the brains of patients with COPD, which is manifested by clinical symptoms such as neuropsychological deficits and mood disorders. The aim of the present study was to investigate brain gray matter change in COPD.MATERIALS AND METHODS:Using voxel-based morphometry based on ...
Magge R - - 2012
BACKGROUND AND PURPOSE:Parameters other than luminal narrowing are needed to predict the risk of stroke more reliably, particularly in patients with <70% stenosis. The goal of our study was to identify clinical risk factors and CT features of carotid atherosclerotic plaques, in a retrospective cohort of patients free of stroke ...
Reardon Leigh C - - 2012
The aim of this study was to evaluate the prognostic value of brain natriuretic peptide (BNP) in outpatients with the Eisenmenger syndrome (ES). BNP is often elevated in patients with cyanotic congenital heart disease. The clinical utility of BNP in patients with cyanotic congenital heart disease and the ES has ...
Mumcu Gonca - - 2012
Background  Saliva contains antimicrobial peptides derived from oral epithelium as well as neutrophils in the innate immune response. The aim of this study was to examine the association between salivary human neutrophil peptide (HNP) 1-3 levels originating from neutrophils and oral ulcers in patients with Behçet's disease (BD). Methods  Ninety-five ...
Liebermann Daniela - - 2012
Previous patient studies suggest that thalamic stroke may yield persistent deficits in several cognitive domains. At present, the subjective dimension and everyday relevance of these impairments is unclear, since many patients with thalamic stroke only show minor changes on physical examination. Here, we have studied subjective consequences of focal thalamic ...
Niimi Y - - 2012
BACKGROUND AND PURPOSE:SAMS is a rare form of SCAVM. We discuss the clinical presentation, endovascular management, and outcome of this disease in our series.MATERIALS AND METHODS:Retrospective review was performed in patients with SCAVM and SAMS who underwent angiography with intent to treat at our institution from 1980 to 2010.RESULTS:One hundred ...
Pathare Anil - - 2012
The objective of our present study was to develop a warfarin dosing algorithm for the Omani patients, as performances of warfarin dosing algorithms vary across populations with impact on the daily maintenance dose. We studied the functional polymorphisms of CYP2C9, CYP4F2 and VKORC1 genes to evaluate their impact on the ...
Shen Hui - - 2012
OBJECTIVE: To determine whether interleukin (IL)-27 is involved in dermatomyositis (DM) and polymyositis (PM). METHODS: Serum IL-27, IL-18 and interferon-γ (IFN-γ) levels in 37 DM and 15 PM were detected by enzyme-linked immunosorbent assay (ELISA). RESULTS: Serum IL-27, IL-18 and IFN-γ levels were significantly higher in DM and PM patients ...
Galindo G - - 2012
Patients with symptoms suggestive of gastroesophageal reflux disease (GERD), such as chest pain, heartburn, regurgitation, and dysphagia, are typically treated initially with a course of proton pump inhibitors (PPIs). The evaluation of patients who have either not responded at all or partially and inadequately responded to such therapy requires a ...
Yokogawa Hideaki - - 2012
BACKGROUND AND OBJECTIVE:To analyze the rationale for performing penetrating keratoplasty (PK) rather than Descemet's stripping automated en-dothelial keratoplasty (DSAEK) in patients with bullous keratopathy (BK) in Japan. PATIENTS AND METHODS:A total of 136 eyes of 130 patients with consecutive BK were enrolled. Patients treated by DSAEK were categorized as the ...
Gerber Bernhard B Division of Hematology, University Hospital Zurich, Zurich, Switzerland. - - 2012
We here investigate the occurrence of fluoride intake-associated alterations in patients with hematologic disease on triazol antifungal medication. Clinical, laboratory, and radiology data of overall 43 patients with hematologic malignancies taking voriconazole (n = 20), posaconazole (n = 8), and itraconazole (n = 4), and a hematologic patient control group ...
Barrie Arthur A Division of Gastroenterology, Hepatology, and Nutrition, University of Pittsburgh School of Medicine, 200 Lothrop Street, Pittsburgh, PA 15213, USA. - - 2013
Eosinophils are implicated in the pathogenesis of inflammatory bowel disease (IBD). A subset of IBD patients develops blood eosinophilia, and the clinical profile of these patients is undefined. We sought to characterize IBD patients with and without eosinophilia. We studied a prospective registry of 1,176 IBD patients followed in a ...
Munhoz Renato P - - 2012
BACKGROUND: A mean of 10 years elapse before patients with Parkinson's disease (PD) reach Hoehn & Yahr (H&Y) stage 4, and 14 years for stage 5. A small proportion of PD patients survive and are ambulatory for ≥20 years. We sought to identify features associated with long-duration PD (dPD). METHODS: ...
Reininghaus Eva - - 2012
ABSTRACT: Huntington's disease (HD) and multiple sclerosis (MS) are both chronic progressive illnesses posing a serious challenge to affected patients and families. Sexual dysfunction in HD as well as in MS is a very common problem, although it is unclear whether the dysfunction is caused by the chronic illness itself ...
Ding Dale - - 2012
: The appropriate management of unruptured arteriovenous malformations (AVMs) remains the subject of controversy. In the present study, we evaluate the radiographic and clinical outcomes of Gamma Knife Radiosurgery (GKRS) for a large cohort of patients with unruptured AVMs. : From a prospective database of 1204 AVM patients treated with ...
Ding Zhen - - 2012
OBJECTIVE: This study was performed to determine the prevalence of chronic kidney disease (CKD) as well as its association with mid-term prognosis in patients with stable premature coronary artery disease (CAD) in a Chinese population. METHODS: Five hundred and twelve patients from Jiangsu Province, China with stable, premature CAD were ...
Sommer Sebastian-Patrick - - 2012
Objectives: a history of myeloproliferative neoplasms is considered to increase the risks in cardiac surgery. In patients with myeloproliferative neoplasms, increased rates of perioperative infections and thromboembolic complications are suspected, but studies analyzing the impact of myeloproliferative neoplasms on results after cardiac surgery are lacking. Methods: 13 patients with the ...
Kulwin Charles Glen - - 2012
: The management of patients with symptoms of tethered cord syndrome (TCS) who lack significant radiographic abnormalities is controversial (1,2,3). One potential marker for TCS is syringomyelia (4,5). However, a syrinx may be a benign and incidental finding (6,7). We evaluate a highly selected cohort of patients who had symptoms ...
Limper Maarten - - 2012
OBJECTIVE: To evaluate whether markers of the acute-phase response in patients presenting with arthralgia and positive anticitrullinated protein antibodies (ACPA) and/or immunoglobulin M rheumatoid factor (IgM-RF) could be predictive for the development of arthritis. METHODS: In total, 137 ACPA- and/or IgM-RF-positive patients were included. Patients were followed annually for the ...
Cerase A - - 2012
Transient ischemic attack (TIA) has to be considered an "alarm bell" of a more or less severe organic or systemic vasculopathy. Positive findings at neuroimaging means tissue damage. The purpose of this retrospective study was to assess the role of neuroimaging in the management of patients presenting with TIA, and ...
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