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Baloda Vandana - - 2012
Intra-abdominal thrombosis is a complication of paroxysmal nocturnal hemoglobinuria (PNH). There is scarcity of data on cases presenting with thrombosis in whom PNH is the predisposing factor. We assessed the role of PNH defect in 81 patients with intra-abdominal thrombosis, 44 patients of Budd Chiari syndrome and 37 patients of ...
Aljaroudi Wael - - 2012
OBJECTIVES: The study sought to investigate whether there is stress-induced worsening of left ventricular mechanical dyssynchrony (LVMD) in patients with ischemic cardiomyopathy (ICM), determine the predictors of LVMD response (LVMDR) and its incremental prognostic value. BACKGROUND: The effect of stress physiology on LVMD in patients with ICM has not been ...
Rektor Ivan - - 2012
BACKGROUND: The effect of brain-vessel pathology on mortality in 57 consecutive PD patients was studied. METHODS: Baseline clinical, neuropsychological, ultrasonographic (US), and MR data obtained from patients who died (n = 18) during a 4-year follow-up period were compared with the data of patients who survived. RESULTS: US/MRI data displayed ...
Bang Ulrich Christian - - 2012
OBJECTIVES: We studied the impact of changes in 25-hydroxyvitamin D (25OHD) and 1,25-dihydroxyvitamin D (1,25(OH)2D) on regulatory T lymphocytes (Tregs) in patients with chronic pancreatitis (CP) and fat malabsorption in a prospective clinical trial. METHODS: The patients were randomized to 1 of 3 treatments during 10 weeks: weekly UV-B in ...
Vassiliadi Dimitra A - - 2012
PURPOSE: The aim of the present study was to describe the variation in adiponectin and resistin levels, 2 adipokines with opposing effects on metabolism, in mechanically ventilated patients with sepsis and their relationships to disease severity and cytokine levels. MATERIALS AND METHODS: An observational prospective study was conducted in a ...
Boyer Laurent - - 2012
The aim of this study was to investigate the neural substrate underlying quality of life (QoL) in patients with schizophrenia. Thirty-one right-handed patients were included. Patients were grouped according to 'high' and 'low' QoL levels. Whole-brain single photon emission computed tomography (SPECT) with (99m)Tc-labeled ethylcysteinate dimer ((99m)Tc-ECD), for the measurement ...
Telenga E D - - 2012
BACKGROUND: The incidence of asthma and obesity is increasing worldwide, and reports suggest that obese patients have more severe asthma. We investigated whether obese asthma patients have more severe airway obstruction and airway hyper-responsiveness and a different type of airway inflammation than lean asthmatics. Furthermore, we assessed the effect of ...
von Haehling Stephan - - 2012
We investigated the prognostic value of midregional pro-A-type natriuretic peptide (MR-proANP). We consecutively evaluated a cath lab cohort of 2,700 patients with symptomatic coronary artery disease (CAD) (74.1% male; acute coronary syndrome, n=1,316; stable angina pectoris, n=1,384) presenting to the cardiology department of a large primary care hospital, all of ...
Dou Yanna - - 2012
The assessment of extracellular fluid volume (ECV) and fluid status is both important and challenging in hemodialysis patients. Extracellular fluid is distributed in two major sub-compartments: interstitial fluid and plasma. A variety of methods are used to assess the ECV, with tracer dilution techniques considered gold standard. However, ECV defined ...
Hosokawa Kohei - - 2012
To characterize bone marrow failure with del(13q), we reviewed clinical records of 22 bone marrow failure patients possessing del(13q) alone or del(13q) plus other abnormalities. All del(13q) patients were diagnosed with myelodysplastic syndrome-unclassified due to the absence of apparent dysplasia. Elevated glycosylphosphatidylinositol-anchored protein-deficient blood cell percentages were detected in all ...
Sarac Ozge - - 2012
Purpose: To report the neuro-ophthalmologic findings in four patients from the same family with cerebellar ataxia, mental retardation, and dysequilibrium syndrome (CAMRQ)2 associated with quadrupedal locomotion. Method: A case series. Results: All four patients carry the private missense mutation, WDR81 p.P856L. The brain Magnetic Resonance Imaging (MRI) of these patients ...
van Bokhorst-de van der Schueren Marian A E - - 2012
BACKGROUND & AIMS: The recently proposed definitions of 'pre-cachexia' and 'cachexia' might offer new possibilities for the detection of malnutrition in patients with rheumatoid arthritis (RA). METHODS: The prevalence of different components of nutritional status and the compiled definitions of 'precachexia' and 'cachexia' were measured in a cohort of 103 ...
Liu Zhenyu - - 2012
Recent studies have shown that cognitive and memory decline in patients with Alzheimer's disease (AD) is coupled with losses of small-world attributes. However, few studies have investigated the characteristics of the whole brain networks in individuals with mild cognitive impairment (MCI). In this functional magnetic resonance imaging (fMRI) study, we ...
Turkdogan Kenan Ahmet - - 2012
BACKGROUND: Crimean-Congo hemorrhagic fever (CCHF) is characterized by vascular dysfunction, indicating the involvement of endothelial cells. C-type natriuretic peptide (CNP) plays a critical role in the coordination of vascular tone and is associated with the prognosis in critically ill patients such as those with sepsis and septic shock. We investigated ...
Gallieni Maurizio - - 2012
BACKGROUND: Patients on dialysis may have abnormal serum levels of Ca, P and parathyroid hormone, with related bone diseases. This population has an increased risk of death, with cardiovascular calcification (CC) a contributing factor. Patients on peritoneal dialysis appear to be at increased risk of hyperlipidemia, a contributing factor to ...
Gerss Joachim - - 2012
OBJECTIVES: Juvenile idiopathic arthritis (JIA) is a chronic inflammatory joint disease affecting children. Even if remission is successfully induced, about half of the patients experience a relapse after stopping anti-inflammatory therapy. The present study investigated whether patients with JIA at risk of relapse can be identified by biomarkers even if ...
Agrinier Nelly - - 2012
The purpose of this study was to examine the prognostic value of serum ECM biomarkers in hypertensive patients with no history of cardiovascular events. In a community-based cohort study of 125 hypertensive patients free of cardiovascular events, we collected clinical data and blood samples to assess serum levels of amino-terminal ...
Podlesek Dino - - 2012
INTRODUCTION: An important pathological feature of idiopathic normal pressure hydrocephalus (iNPH) is a dysfunction of cerebrospinal fluid dynamics. Considering the delicate olfactory structures it appears possible that the olfactory bulb (OB) is compromised by this disease. Reports on the anatomy of the olfactory bulb and smell function in patients with ...
Noel Nicolas - - 2012
OBJECTIVES: To describe the small retinal and systemic vessel involvement in Takayasu's arteritis. METHODS: We described 3 patients with Takayasu's arteritis and small retinal vessel occlusion seen in our departement between 2004 and 2011. We performed an extensive literature review and provided a global analysis of small retinal vessel involvement ...
Dan Kazuhiro - - 2012
Background: Renal insufficiency plays a critical role in the pathogenesis of ischemic heart disease. The aim of the present study was to investigate the prevalence of renal dysfunction and its impact on prognosis in patients with left main coronary artery disease (LMCAD) and stable angina pectoris. Methods and Results: A total of ...
Khalil Eman S-D - - 2012
PURPOSE: We assessed the prevalence of sleep disordered breathing (SDB) and investigated its effects on the muscle functional capacity and quality of life (QoL) among chronic kidney disease (CKD) Egyptian patients, either maintained or not maintained on hemodialysis (HD). METHODS: The study population comprised 100 CKD patients who were divided ...
Aschbacher Kirstin K Department of Psychiatry, University of California, San Francisco, CA, United States. - - 2012
A dynamic systems model was used to generate parameters describing a phenotype of Hypothalamic-Pituitary-Adrenal (HPA) behavior in a sample of 36 patients with chronic fatigue syndrome (CFS) and/or fibromyalgia (FM) and 36 case-matched healthy controls. Altered neuroendocrine function, particularly in relation to somatic symptoms and poor sleep quality, may contribute ...
Viau Krista - - 2012
Glutaric acidemia type 1 (GA-1) is an autosomal recessive disorder of lysine, hydroxylysine, and tryptophan metabolism. Patients may present with brain atrophy, macrocephaly, and acute dystonia secondary to striatal degeneration typically triggered by an infection, fever, and/or dehydration. This disorder is identified on expanded newborn screening by increased glutarylcarnitine. We ...
Lipton Michael L - - 2012
To identify and characterize otherwise occult inter-individual spatial variation of white matter abnormalities across mild traumatic brain injury (mTBI) patients. After informed consent and in compliance with Health Insurance Portability and Accountability Act (HIPAA), Diffusion tensor imaging (DTI) was performed on a 3.0 T MR scanner in 34 mTBI patients ...
Kim Suk Jae - - 2012
Background: Aortic arch atheroma (AAA) has been accepted as a possible embolic source in patients with ischemic stroke, especially cryptogenic stroke. However, despite its well-known role as a risk factor for stroke, research focused on the mechanism or characteristics of stroke caused by AAA is insufficient. In this study, we ...
Kowalska-Oledzka E - - 2012
Background.  'Black dots' are macrocomedo-like round structures localized to the follicular ostium, and are considered a specific trichoscopic feature of alopecia areata (AA). Aim.  To characterize specific features of 'black dots', and assess their possible presence in common hair and scalp disorders. Methods.  In total, 107 patients with hair loss ...
Zhang Wei - - 2012
Inflammation may be associated with mortality in dialysis patients. This study aims to summarize the prognostic value of two common inflammatory markers, C-reactive protein (CRP) and Interleukin-6 (IL-6) for dialysis outcome. A total of 109 CRP studies and 22 IL-6 studies were identified from PubMed and EMBASE after systematic searching ...
Sharma Jagdish C - - 2012
OBJECTIVES: To study the relationship between olfaction and body weight profile in Parkinson's disease. METHODS: Prospective assessment of 99 PD patients for clinical parameters, olfaction using UPSIT and current and previous body weight. Patients were categorised as weight losers (WL) and non-weight losers (NWL) depending on change of weight from ...
Jin Chenwang - - 2012
Migraine is a primary headache disorder characterized by recurrent attacks of throbbing pain associated with neurological, gastrointestinal and autonomic symptoms. Previous studies have detected structural deficits and functional impairments in migraine patients. However, researchers have failed to investigate the functional connectivity alterations of regions with structural deficits during the resting ...
Kurisu Satoshi - - 2012
INTRODUCTION: We assessed whether QT interval was still different between male and female patients with primary aldosteronism. We also assessed the gender difference in the relation between serum potassium level and QT interval. MATERIALS AND METHODS: The study population consisted of 80 patients with newly diagnosed primary aldosteronism. There were ...
Rioux-Massé Benjamin - - 2012
BACKGROUND: For patients with thrombocytopenia without bleeding risk factors, a platelet transfusion trigger of 10 × 10(9) /L is recommended. No studies have evaluated the clinicians' decision-making process leading to trigger changes. STUDY DESIGN AND METHODS: We report on the evaluation of trigger changes and the relation with bleeding. Eighty patients previously ...
Kappler M - - 2012
BACKGROUND: The prevention and treatment of liver disease associated with cystic fibrosis remain a significant unresolved problem. AIM: To assess the long-term effects of continuous ursodeoxycholic acid (UDCA) therapy in cystic fibrosis patients with constantly elevated serum liver enzymes. METHODS: The primary endpoint was the incidence of overt liver disease. ...
Gaydukova Inna - - 2012
The purpose of this study was to investigate autonomous regulation of the cardiac activity by means of the heart rate variability (HRV) assessment and possible influence of conventional cardiovascular risk factors and disease activity parameters on it in patients with psoriatic arthritis (PsA). In total, 38 patients with the reliable ...
Gangemi Sebastiano - - 2012
OBJECTIVES: Protein oxidation plays a key role in the pathogenesis of oncological diseases. In this study, we analyzed the oxidative stress in untreated multiple myeloma (MM) patients and in patients affected by monoclonal gammopathy of uncertain significance (MGUS). METHODS: We evaluated serum levels of advanced oxidation protein products (AOPPs), advanced ...
Fusegi Keiko - - 2012
We report on 8 patients with Parkinson's disease (PD) who experienced suddenly episodes of speech unrelated to the topic of conversation or wrote sentences unrelated to the context. During these episodes and later, unless pointed out, patients were unaware of the behavior. We called this phenomenon Unrelated Communication Interlude (UCI). ...
Lin Yen-Hung - - 2012
OBJECTIVE:: Primary aldosteronism is the most frequent cause of secondary hypertension and is associated with more prominent left ventricular hypertrophy and increased myocardial fibrosis. However, the reversibility of cardiac fibrosis is still unclear. Our objective was to investigate myocardial fibrosis in primary aldosteronism patients and its change after surgery. METHOD:: ...
Durante Cosimo - - 2012
Context:Serum thyroglobulin (Tg) assays are considered fundamental in postoperative surveillance of differentiated thyroid cancer (DTC) patients. However, the postsurgical profile of Tg levels has never been specifically investigated in patients who do not undergo radioiodine remnant ablation (RRA).Objectives:Our objective was to explore the evolution of Tg levels over time in ...
Villeneuve Sylvia - - 2012
ABSTRACT INTRODUCTION:Cognitive impairment is a frequent feature of chronic obstructive pulmonary disease (COPD). However, the proportion of COPD patients with mild cognitive impairment (MCI) is still unknown, and no screening test has been validated to date for detecting MCI in this population. OBJECTIVE:To determine the frequency and subtypes of MCI ...
Anastasilakis Athanasios D - - 2012
OBJECTIVE: Patients treated with intravenous zoledronate frequently experience an acute phase reaction (APR) characterized by flu-like symptoms and increased levels of inflammatory cytokines. We aimed to define the role of various cytokines/adipocytokines in zoledronate-induced APR and develop a prognostic model for its prediction. PATIENTS AND MEASUREMENTS: Fifty-one postmenopausal women with ...
Alpaslan Mete - - 2012
OBJECTIVE: To assess the aortic root function in patients with pseudoexfoliation syndrome (PEXS). METHODS: In this case- controlled observational study, aortic root function in 31 PEXS patients (mean age 71±9 years) and 29 controls of similar ages (mean age 69±9 years) were evaluated by M-mode transthoracic echocardiography. Aortic cross-sectional compliance ...
Richette Pascal - - 2012
BACKGROUND: Psoriasis is an important clinical feature in spondyloarthritis. However, the influence of psoriasis on the clinical, functional and imaging features of patients with inflammatory back pain (IBP) related to spondyloarthritis is not known.OBJECTIVES: To determine the prevalence of psoriasis and its impact in patients with recent IBP suggestive of ...
Szmit Sebastian - - 2012
Background/Aims: The purpose of the present study was to determine the relationship between iatrogenic arterial hypertension or baseline cardiovascular comorbidities and outcomes in metastatic renal cell cancer (mRCC) patients treated with sorafenib. Methods: The study included 148 mRCC patients treated with sorafenib, 63 patients (43%) had preexisting hypertension, 18 patients ...
Yilmaz Murvet - - 2012
Background/Aims: Cardiac valve calcification (CVC) and left ventricular (LV) abnormalities are common indicators of a poor prognosis in dialysis patients. We determined the prevalence of hypertension, CVC, LV hypertrophy (LVH) and LV geometry in peritoneal dialysis (PD) patients. Methods: Eighty-seven patients (50 female; mean age 42 ± 13 years; mean ...
Wang H - - 2012
BACKGROUND: Atrial fibrillation (AF) recurrence after ablation is difficult to predict. The development of AF is associated with inflammation, and inflammatory markers such as big endothelin-1 (big ET-1) reflect inflammatory status. It is unknown, however, whether big ET-1 can be used as a predictor for AF recurrence. The aim of ...
Marti Jennifer L - - 2012
BACKGROUND: Patients receiving lithium therapy are at elevated risk of developing hyperparathyroidism. In lithium-associated hyperparathyroidism (LAH), the incidence of multiglandular disease (MGD) is unclear, and the need for routine bilateral cervical exploration remains controversial. Therefore, in LAH patients, surgical approaches, pathologic findings, cure rates, and factors associated with persistent or ...
Somlóová Z - - 2012
Primary aldosteronism (PA) is the most common cause of endocrine hypertension with a high frequency of cardiovascular complications. We found in our previous study higher occurrence of metabolic disturbances in patients with idiopathic hyperaldosteronism (IHA) compared to subjects with aldosterone-producing adenoma (APA). The aim of our present study is to ...
Madanagobalane Shraddha - - 2012
Background:  Psoriasis is an inflammatory disease of the skin and joints. Previous studies have shown a higher prevalence of metabolic syndrome (MS) in psoriatic patients. Recent studies show that non-alcoholic fatty liver disease (NAFLD) is also frequent in psoriasis patients. Objectives:  To investigate the occurrence and severity of NAFLD in ...
Rolfast Corina L - - 2012
ABSTRACT: INTRODUCTION: During therapeutic hypothermia (TH) ECG abnormalities such as Osborn waves and/or ST segment elevation have been described. However, the incidence and prognostic value of these ECG changes are uncertain given the small-scale studies that have been carried out to date. The aim of this study is to further ...
Lü Fei - - 2012
Frequent ventricular premature complexes (VPCs), particularly those without troublesome palpitations, are often regarded as a benign arrhythmia and are not treated other than with reassurance. However, VPCs can contribute to left ventricular (LV) dysfunction in the absence of symptoms. The present study was designed to investigate whether catheter ablation of ...
Ohkura Noriyuki - - 2012
SUMMARY AT A GLANCE: To investigate the pathophysiology of cough variant asthma, we measured methacholine-induced cough. A higher number of coughs occurred in patients with cough variant asthma with even mild bronchoconstriction compared with normal subjects. Heightened cough response to bronchoconstriction is a feature of cough variant asthma. ABSTRACT: Background ...
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