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Chalasani Naga N Division of Gastroenterology and Hepatology, Indiana University School of Medicine, 1050 Wishard Boulevard, RG 4100, Indianapolis, IN 46202, USA. - - 2012
Flavocoxid is a prescription medical food that is used to treat osteoarthritis. It is a proprietary blend of 2 flavonoids, baicalin and catechins, which are derived from the botanicals Scutellaria baicalensis and Acacia catechu, respectively. To describe characteristics of patients with acute liver injury suspected of being caused by flavocoxid. ...
Hahn K - - 2012
Abstract Cognitive deficits are often observed during the acute stage of encephalitis. It is presumed, that they persist and influence the long term outcome, but data are very limited. 47 Patients with a definite or highly probable diagnosis of acute encephalitis were identified through retrospective analysis and prospectively followed up ...
Kim Ji Hyun - - 2012
Purpose:  Previous neuroimaging studies provide growing evidence that patients with juvenile myoclonic epilepsy (JME) have both structural and functional abnormalities of the thalamus and frontal lobe gray matter. However, limited data are available regarding the issue of white matter (WM) involvement, making the microstructural WM changes in JME largely unknown. ...
Li Zhenfang - - 2012
Background/Aims: The present study was performed to establish a scientific method for the typing of portal vein tumor thrombosis (PVTT) by investigating the degrees of esophageal-gastro varices, the incidences of rupturing hemorrhage and the prognoses of different types of patients with PVTT. Methodology: We collected 76 patients with HCC and ...
Lee Julia Yu-Yun - - 2012
OBJECTIVE: Persistent pruritic eruptions (PPE) are common among our patients with adult-onset Still disease (AOSD). We aimed to characterize the clinicopathologic features of the AOSD-associated evanescent and persistent rashes. METHODS: We reviewed the clinicopathologic features of the skin lesions from all AOSD cases diagnosed in our hospital during 1988 to ...
Maier Franziska - - 2012
BACKGROUND: This study investigated impaired self-awareness of motor deficits in nondemented, nondepressed Parkinson's disease (PD) patients during a defined clinical on state. METHODS: Twenty-eight PD patients were examined. Patients' self-ratings and experts' ratings of patients' motor performance were compared. Patient-examiner discrepancies and level of impairment determined severity of impaired self-awareness. ...
Migirov Lela - - 2012
OBJECTIVE: To investigate a possible contribution of handedness to the development of unilateral acquired cholesteatoma. PATIENTS: All patients with unilateral acquired cholesteatoma attending otorhinolaryngology clinic between August 2009 and February 2012 were asked about their handedness. RESULTS: The study group consisted of 237 right-handed and 31 left-handed (11.8%) patients who ...
Stefano Cristina Di - - 2012
Objective. Decompressive craniectomy is often emergently performed in an effort to reduce intracranial hypertension. After this urgent intervention, brain-injured patients often start rehabilitation programs but are left with a skull defect. Cranioplasty is often performed in these situations in order to repair this defect, mainly for cosmetic reasons and/or the ...
Papageorgiou Eleni - - 2012
Aim of the present study was to identify efficient compensatory gaze patterns applied by patients with homonymous visual field defects (HVFDs) under virtual reality (VR) conditions in a dynamic collision avoidance task. Thirty patients with HVFDs due to vascular brain lesions and 30 normal subjects performed a collision avoidance task ...
Eryılmaz A - - 2012
Obstructive sleep apnea syndrome (OSAS) and Laryngopharyngeal reflux disease (LPR) are both common health problems causing severe morbidity. Since they have similar risk factors, the prevalence of LPR among patients with OSAS is higher compared with general population. However, there exist only a few studies showing the potential causal relation ...
Lipson Aliza - - 2012
Morbidity and mortality secondary to premature cardiovascular disease (CVD) in systemic lupus erythematosus (SLE) remain significant issues. The pathogenesis of CVD in SLE patients has not been fully explored. Epicardial adipose tissue (EAT) is believed to contribute to atherosclerosis development, through a paracrine and systemic inflammatory effect. We measured EAT ...
Li M - - 2012
PURPOSE: To investigate the relationship between severity of hypernatremia and the risk of death for patients with traumatic brain injury (TBI) who have been admitted to the neurosurgical intensive care unit (NICU). METHODS: A total of 1044 patients with TBI were admitted to our NICU from January 2005 to January ...
Martínez-Avilés Luz - - 2012
JAK2V617F-negative essential thrombocythemia (ET) is a heterogeneous disease including clonal cases and others without evidence of clonality. However, it is unknown if the detection of myeloid clonality in JAK2V617F-negative ET patients confers a different clinical outcome than those in whom clonal hematopoiesis cannot be demonstrated. The objective of the present ...
Bonanad Clara - - 2012
©2012 Wiley Periodicals, Inc. Heat shock protein 60 (HSP60) is a mitochondrial protein constitutively expressed in the majority of cells, and its expression is up-regulated by a variety of stressors. In heart failure, HSP60 is released from cardiomyocytes. The authors speculate that increased serum HSP60 (sHSP60) may be related to ...
González-Lama Yago - - 2012
BACKGROUND: Methotrexate is useful in inflammatory bowel disease (IBD), but its role is secondary because of its limited experience and a supposedly unfavorable safety profile. AIM: To describe the efficacy and safety of methotrexate in a long-term real clinical practice. METHODS: Retrospectively reviewed records of IBD patients treated with methotrexate ...
Shiina Kazuki - - 2012
The chronic obstructive pulmonary disease (COPD) and obstructive sleep apnea (OSA) have been recently much focused as independent risks for cardiovascular disease. Furthermore, the complication of both has a worse prognosis compared with patients with only one of these diseases. However, the details of the underlying mechanisms of this worsened ...
Mohanty Chandan B - - 2012
Objective. To establish predisposing factors of high cervical disc degeneration (HCDD) with an emphasis on the presence or absence of craniovertebral junction (CVJ) pathology by a retrospective analysis of clinical and radiologic parameters of patients operated at our institute. Methods. Thirty-seven patients of C3-4 prolapsed intervertebral disc (PIVD) were compared ...
Reiberger Thomas - - 2012
BACKGROUND: Transient elastography (TE) is a noninvasive tool to assess hepatic fibrosis by measuring liver stiffness (LS). Recent studies suggest that TE may be used to screen for liver cirrhosis and clinically significant portal hypertension (³ 10 mmHg; CSPH), whereas data on the clinical applicability of TE are limited. METHODS: Among 695 ...
Caramaschi Paola - - 2012
OBJECTIVE: To evaluate the prevalence of digital necrosis requiring surgical amputation in a single-center group of patients with systemic sclerosis (SSc) and to compare the characteristics of patients with and those without this severe complication. METHODS: We reviewed the medical records of 188 patients with SSc [162 women, 26 men, ...
Prada Carlos E - - 2012
Ornithine transcarbamylase (OTC) deficiency is a urea cycle defect with varying frequency and severity of episodes of hyperammonemia. We report three patients with OTC deficiency with recurrent pancreatitis. The pathogenesis of acute pancreatitis in this patient population requires further elucidation. Pancreatitis significantly affected dietary/metabolic management and increased frequency of hospitalizations.
Arunachalam M - - 2012
Background  Although non-segmental vitiligo is commonly considered an autoimmune disease, the possible differences between non-segmental vitiligo patients with and without autoimmune signals have not been clearly established. Objective  To perform a comparison of non-segmental vitiligo patients with autoimmune signals (AIS) vs. those without autoimmune signals (NAIS) in regards to clinical ...
Emre Selma - - 2012
The pathogenesis of seborrheic dermatitis (SD) has not been clearly identified, and many factors are thought to play a role in its development. Recently, new studies have focused on increased oxidative stress (OS) in T cell-mediated skin diseases like psoriasis, contact dermatitis, and atopic dermatitis. However, there is no study ...
Tavilani Heidar - - 2012
BACKGROUND: Oxidative stress has been known for having a key role in pathogenesis of many diseases. The aim of this study was to investigate the oxidative stress and also the relationship between antioxidant system statuses and lung function in patients with COPD and smokers and non-smokers subjects. METHODS: Thirty patients ...
Kutukculer Necil - - 2012
B lymphocyte subpopulations, previously defined classification schemes (Freiburg, Paris, EuroClass), TNFRSF13B (TACI), TNFRSF13C (BAFF-R), TNFSF13 (APRIL) gene mutations, CTLA-4 and ICOS gene polymorphisms were analyzed in 25 common variable immunodeficiency (CVID) patients and 25 healthy controls. Patients were also divided into two subgroups due to some disease severity criteria. SG ...
El Dayem Soha M Abd - - 2012
OBJECTIVE: To evaluate progression of left ventricular (LV) structural and functional changes in patients with type 1 diabetes and effect of glycemic control on these changes. METHODS: A prospective, longitudinal study consisted of 48 patients who were originally studied. At two years follow-up, 44 patients were reevaluated, 35 patients from ...
Gimelli Alessia - - 2012
PURPOSE: Obesity is a significant and independent risk factor for cardiovascular disease, and assessing ischaemia in obese patients is clinically important but sometimes difficult because of imaging artefacts. The aim of this study was to evaluate the feasibility and diagnostic accuracy of stress/rest imaging with a cadmium-zinc telluride (CZT) camera ...
Høiseth Gudrun - - 2012
BACKGROUND: Hair levels of ethyl glucuronide (EtG) are often used to differentiate social drinking from heavy drinking. Patients with decreased kidney function have delayed excretion of EtG, and increased incorporation into hair could be suspected. The aim of this study was to compare hair EtG levels in patients with decreased ...
Biagi Federico - - 2012
INTRODUCTION: Whipple's disease is a rare chronic infection caused by Tropheryma whipplei. Although most patients respond to antibiotics, in some of them the start of the treatment is followed by recurrence of inflammation. Since polymerase chain reaction is negative for Tropheryma whipplei, this reinflammation cannot be a relapse of Whipple's ...
Ricchi Paolo - - 2012
Few data are available on the prevalence and the risk factors for the presence of kidney stones and hyperuricemia in patients with thalassemia intermedia. We retrospectively reviewed the charts and radiological studies of 89 patients with thalassemia intermedia followed at our clinic with routine biochemical examination and radiological imaging of ...
Yang Jing - - 2012
Cumulative evidence of gray matter abnormalities in semantic dementia (SD) has been reported using voxel-based morphometry (VBM). However, these studies have not been reviewed quantitatively. To estimate gray matter changes in SD quantitatively, we systematically searched whole-brain VBM studies comparing SD patients with healthy controls in the PubMed, ISI Web ...
Schwartz Matthew C - - 2012
Hepatic fibrosis is an important complication after Fontan surgery in patients with single-ventricle congenital heart disease. Few reports of hepatic histology in these patients exist, and sinusoidal fibrosis has been described. We aimed to characterize fibrosis at liver biopsy procedure in patients with previous Fontan surgery and to identify patient ...
Lazzeri Chiara - - 2012
Abstract Aims: To assess the impact of microalbuminuria on the development of acute kidney injury and to investigate its prognostic role at long term follow-up in 526 consecutive patients with ST elevation myocardial infarction without previously known diabetes. Methods: Microalbuminuria was measured using immunonephelemetry in the urine collected in the ...
Rana Abdul Qayyum - - 2012
Corticobasal degeneration is a progressive neurodegenerative disease involving the cerebral cortex and basal ganglia and leads primarily to motor symptoms and cognitive dysfunction. Unilateral arm dystonia is a common presenting symptom in many patients with corticobasal degeneration. This study attempts to determine if a relationship exists between arm dystonia in ...
Asao Rin - - 2012
Podocalyxin (PCX) is present on the apical cell membrane of podocytes and is shed in urine from injured podocytes. Urinary podocalyxin (u-PCX) is associated with severity of active glomerular injury in patients with glomerular diseases. This study examined the relationship between number of urinary podocytes, levels of u-PCX, and glomerular ...
Teunissen Ce - - 2012
Background: Oxidative stress plays an important role in multiple sclerosis (MS). Isoprostanes are biomarkers for oxidative stress and have been related to neurological disease progression.Objective: To study whether plasma isoprostane levels were related to disease progression in MS.Methods: Plasma levels of 8,12-iso-iPF2alpha-VI were determined in 17 patients with clinically isolated ...
Sachs Gabriele - - 2012
Functional magnetic resonance (fMRI) imaging was used to measure amygdala activation in an emotional valence discrimination task in clinically stable patients with schizophrenia treated with atypical antipsychotics and healthy controls. No difference was detected between patients with schizophrenia and controls.
Cho Min-Chul - - 2012
BACKGROUND: Work-up of post-transplant lymphoproliferative disorders (PTLDs) often involves bone marrow (BM) examinations. We evaluated 23 transplant patients with PTLDs to investigate incidence of BM involvement and associated morphologic changes as well as prognosis. METHODS: We retrospectively assessed BM findings of 23 transplant patients with PTLDs who had undergone BM ...
Karroum Elias Georges - - 2012
OBJECTIVES: To evaluate the topography of restless legs syndrome (RLS) sensations and to compare subgroups of patients based on RLS topography. METHODS: Forty-four treated patients with primary RLS were interviewed and reported the localization of RLS sensations on body diagrams. RESULTS: RLS sensations were felt deep inside the muscles of ...
Lai Maria Eliana - - 2012
BackgroundLittle information is available about the kidney's involvement in patients with β-thalassaemia major (TM). In particular, there are no studies reporting the outcome of renal function over time.MethodsIn this retrospective study, we evaluated the changes in estimated glomerular filtration rate (eGFR) in 81 adult patients with TM followed for 10 ...
Edlow Jonathan A - - 2012
Presidential election years are often filled with snappy slogans. One of the best was Bill Clinton's "It's the economy, stupid" in 1992. In the campaign to prevent subsequent strokes in patients presenting with transient cerebral ischemia (TIA), we might borrow a page from Clinton's playbook.
Baloda Vandana - - 2012
Intra-abdominal thrombosis is a complication of paroxysmal nocturnal hemoglobinuria (PNH). There is scarcity of data on cases presenting with thrombosis in whom PNH is the predisposing factor. We assessed the role of PNH defect in 81 patients with intra-abdominal thrombosis, 44 patients of Budd Chiari syndrome and 37 patients of ...
Pianta Timothy J - - 2012
SUMMARY AT A GLANCE: In stable asymptomatic HD patients, highly sensitive TNT is persistently elevated above normal values and is not affected by dialysis. Highest values were evident in those with cardiovascular disease. It is recommended that in at risk individuals on HD, a baseline hsTNT should be measured for ...
Pasoto Sandra Gofinet - - 2012
Antiphospholipid antibodies (aPL) and antiphospholipid syndrome (APS) have been described in primary Sjögren's syndrome (pSS) with controversial findings regarding aPL prevalence and their association with thrombotic events. We evaluated 100 consecutive pSS patients (American-European criteria) and 89 age-gender-ethnicity-matched healthy controls for IgG/IgM anticardiolipin (aCL), IgG/IgM anti-beta2-glycoprotein-I (aβ2GPI), and lupus anticoagulant ...
Aljaroudi Wael - - 2012
OBJECTIVES: The study sought to investigate whether there is stress-induced worsening of left ventricular mechanical dyssynchrony (LVMD) in patients with ischemic cardiomyopathy (ICM), determine the predictors of LVMD response (LVMDR) and its incremental prognostic value. BACKGROUND: The effect of stress physiology on LVMD in patients with ICM has not been ...
Kurne Asli - - 2012
Soluble (s) CD14, being a receptor for lipopolysaccharides (LPSs) may inhibit LPS-triggered apoptosis and T lymphocyte proliferation. C to T exchange at position -159 in the promoter region of the CD14 gene might lead to higher sCD14 levels. Limited number of groups have studied whether these polymorphisms might influence the ...
França Marcondes C MC - - 2012
BackgroundMutations in SPG11 are the most frequent known cause of autosomal recessive hereditary spastic paraplegia. Corpus callosum thinning is a hallmark of the condition but little is known about damage to other structures in the CNS.ObjectiveTo evaluate in vivo cerebral damage in patients with SPG11 mutations.Methods5 patients and 15 age ...
Kampschreur Linda M - - 2012
Chronic Q fever develops in 1 to 5% of patients infected with Coxiella burnetii. The risk for chronic Q fever endocarditis has been estimated to be ≈ 39% in case of preexisting valvulopathy and is potentially even higher for valvular prostheses. Since 2007, The Netherlands has faced the largest Q ...
Rektor Ivan - - 2012
BACKGROUND: The effect of brain-vessel pathology on mortality in 57 consecutive PD patients was studied. METHODS: Baseline clinical, neuropsychological, ultrasonographic (US), and MR data obtained from patients who died (n = 18) during a 4-year follow-up period were compared with the data of patients who survived. RESULTS: US/MRI data displayed ...
Bang Ulrich Christian - - 2012
OBJECTIVES: We studied the impact of changes in 25-hydroxyvitamin D (25OHD) and 1,25-dihydroxyvitamin D (1,25(OH)2D) on regulatory T lymphocytes (Tregs) in patients with chronic pancreatitis (CP) and fat malabsorption in a prospective clinical trial. METHODS: The patients were randomized to 1 of 3 treatments during 10 weeks: weekly UV-B in ...
von Haehling Stephan - - 2012
We investigated the prognostic value of midregional pro-A-type natriuretic peptide (MR-proANP). We consecutively evaluated a cath lab cohort of 2,700 patients with symptomatic coronary artery disease (CAD) (74.1% male; acute coronary syndrome, n=1,316; stable angina pectoris, n=1,384) presenting to the cardiology department of a large primary care hospital, all of ...
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