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Liu Qing Q From the Department of Cardiology, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China. Supported by the National Natural Science Foundation of China (grant no. 81170285) and the Research Fund for the Doctoral Program of Higher Education of China (grant no. 20101106110012). Q. Liu, MD; A. Dang, MD, PhD; B. Chen, MD; N. Lv, MD, PhD; X. Wang, MD; D. Zheng, MD, Department of Cardiology, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College. Address correspondence to Dr. A. Dang, Department of Cardiology, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100037, China. E-mail: amdang@fuwaihospital.org. Accepted for publication April 17, - - 2014
Increased levels of N-terminal pro-brain natriuretic peptide (NT-proBNP) are associated with cardiovascular morbidity and mortality. Inflammation may also affect levels of NT-proBNP. We investigated the relationship of NT-proBNP with inflammation, disease activity, disease severity, and progression of Takayasu arteritis (TA). Plasma levels of NT-proBNP were determined in 68 patients with ...
Palomo-Piñón Silvia S Unidad de Investigación Médica en Enfermedades Nefrológicas, UMAE Hospital de Especialidades "Dr. Bernardo Sepúlveda Gutiérrez", Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, México, D.F., México. Electronic address: - - 2014
Residual renal function (RRF) has been identified as the most important component in dialysis adequacy and has a strong effect on clinical outcomes. This justifies any effort in understanding the mechanism behind the preservation or decline in RRF. The aim of this study was to analyze the possible association of ...
Christ Torsten T Departments of Pharmacology and Toxicology and t.christ@uke.de - - 2014
Atrial fibrillation (AF) is the most common heart rhythm disorder. Transient postoperative AF can be elicited by high sympathetic nervous system activity. Catecholamines and serotonin cause arrhythmias in atrial trabeculae from patients with sinus rhythm (SR), but whether these arrhythmias occur in patients with chronic AF is unknown. We compared ...
Ju Weizhu W Department of Cardiology, the First Affiliated Hospital of Nanjing Medical University, Nanjing, - - 2014
-Atrial tachycardias (ATs) following extensive ablation are increasingly common and challenging arrhythmias. The prolonged intra-atrial conduction time (IACT) during ATs in the milieu may complicate the mapping of focal ATs. The present study characterized the electrophysiological features of ATs in this unique setting and to further delineate an effective mapping ...
Stryjewski Piotr J PJ Cardiology Department, Chrzanow City Hospital, 16 Topolowa St., 32-500, Chrzanow, Poland, - - 2014
The aim of this study was to assess the clinical significance of N-terminal pro-B-type natriuretic peptide (NT-proBNP) concentrations in the differentiation of patients with cardiac and reflex syncope. The study included a group of 100 patients (56 women, 44 men), aged 18-77 years (mean 52.6 ± 16.7), with a history of reflex (group ...
Voight Jessica J Division of Cardiology, Veterans Administration Medical Center, Minneapolis, MN, USA; Department of Medicine, University of Minnesota, Minneapolis, MN, USA. Electronic address: - - 2014
Radiofrequency ablation (RFA) is considered a curative procedure for typical atrial flutter (AFL), however, patients remain at risk for developing new atrial fibrillation (AF). We sought to determine the incidence and predictors of new-onset AF and stroke after RFA of isolated AFL in a multicenter cohort. We included 315 consecutive ...
Mebazaa Alexandre A Université Paris Diderot, PRES Sorbonne Paris Cité and Saint Louis Lariboisière University Hospitals, U942 Inserm, Paris, France - - 2014
-Whether heart failure (HF) increases the risk of venous thromboembolism (VTE) is not well established. In the phase III MAGELLAN trial, extended-duration rivaroxaban was compared with standard-duration enoxaparin followed by placebo for VTE prevention in 8101 hospitalized acutely ill patients with or without HF. The aim of this analysis was ...
Stämpfli Simon F SF Department of Cardiology, University Heart Center, University Hospital Zurich, Zurich, - - 2014
We report the case of a young patient with repaired Ebstein's anomaly who developed severe tachycardia-induced cardiomyopathy and a large apical thrombus as a consequence of sustained atrial flutter with a 2:1 conduction. In spite of a dramatic course in hospital with prolonged mechanical resuscitation and extracorporeal membrane oxygenation, she ...
Sobczak Sebastian - - 2014
INTRODUCTION sST2 protein is a new biomarker. A prognostic value of sST2 in chronic heart failure (CHF) is still unclear. OBJECTIVES The evaluation of sST2 importance in patients with CHF at the 1-year follow-up after hospitalization for prediction: cardiovascular death, rehospitalization, need for increase diuretic therapy and/or worsening New York Heart Association ...
Wi Jin J Division of Cardiology, Department of Internal - - 2014
The mechanism of complex fractionated atrial electrogram (CFAE) in patients with atrial fibrillation (AF) remains controversial. This study investigated the relationship between CFAE and left atrial (LA) wall thickness. LA muscular wall thickness (excluding fat) was measured by cardiac computed tomography in 31 patients with AF (12 paroxysmal, 19 persistent) ...
Setoguchi Masahiko M Department of Cardiology, Kameda General Hospital, Kamogawa, Japan, - - 2014
Although there have been several studies regarding heart failure with preserved ejection fraction (HFpEF), investigations of the risk factors for readmission of Japanese patients with HFpEF remain scarce. Therefore, our goal was to identify the risk factors for readmission of Japanese patients with heart failure (HF), particularly those with HFpEF. ...
Alonso-Martínez José Luis JL Department A of Internal Medicine, Hospital Complex of Navarra, Irunlarrea 6, 31008 Pamplona, Spain. Electronic address: - - 2014
After an acute pulmonary embolism few long-term prognostic factors have shown to be of practical use. We hypothesized that, as in heart failure, natriuretic peptides could serve as biomarkers of a late deleterious prognosis. Consecutive patients admitted to an Internal Medicine ward diagnosed with acute pulmonary embolism were traced through ...
Miyazaki Shinsuke S Cardiovascular Center, Tsuchiura Kyodo Hospital, Tsuchiura, Ibaraki, Japan. Electronic address: - - 2014
The superior vena cava (SVC) is an infrequent but important source of atrial fibrillation (AF), but is not always easy to identify. This study aimed to identify predictors of an arrhythmogenic SVC (a-SVC) in patients undergoing AF ablation. Eight hundred thirty-six consecutive patients undergoing AF ablation were analyzed. All patients ...
Avci Anil - - 2014
Abstract Objectives. The aim of this study was to assess whether NLR levels are associated with echocardiographic parameters, New York Heart Association (NYHA) functional class, or B- type natriuretic peptide (BNP) levels in patients with idiopathic dilated cardiomyopathy. Design. Eighty-seven patients with idiopathic dilated cardiomyopathy were included prospectively from 2009 ...
Li Qin Q Division of Cardiology, Peter Munk Cardiac Center, Toronto General Hospital, Toronto, Canada - - 2014
-The aim of the study was to clarify the relationship between genotype status and major cardiovascular outcomes in a large cohort of Hypertrophic Cardiomyopathy (HCM) patients. -Genetic testing was performed in 558 consecutive proband HCM patients. Baseline and follow up (mean follow up 6.3 years) clinical and echocardiographic data were ...
Rangel Inês I Cardiology Department, Centro Hospitalar de S. João, Porto, - - 2014
Objective: To assess the prognostic significance of iron deficiency (ID) in a chronic heart failure (CHF) outpatient population. Methods and Results: We prospectively evaluated 127 patients with stable CHF and left ventricular ejection fraction ≤45%. Clinical and analytical data as well as information regarding the occurrence of the composite endpoint ...
Williams Matthew R MR University of California - San Diego & Rady Children's Hospital San Diego, San Diego, CA - - 2014
-Many patients with congenital heart disease require permanent pacing for rhythm management but cannot undergo transvenous lead placement. In others, epicardial scarring prohibits adequate sensing and pacing thresholds using epicardial leads. This study describes long-term lead performance using a transmural atrial (epicardial-to-endocardial) pacing approach in patients with congenital heart disease. ...
Ozcan Cevher C Cardiac Arrhythmia Service, Institute for Heart, Stroke and Vascular Care, Massachusetts General Hospital, Boston, MA, USA Division of Cardiovascular Medicine, University at Buffalo School of Medicine and Biomedical Sciences, NY, - - 2014
To determine the incidence and predictors of atrial fibrillation (AF) and its impact on survival in patients with other forms of supraventricular arrhythmias (SVAs) including atrial flutter (AFL), atrial tachycardia (AT), atrioventricular reentrant (AVRT), and AV nodal reentrant tachycardia (AVNRT). We hypothesized that SVA may increase risk of AF and ...
Zubaid Mohammad M Department of Medicine, Faculty of Medicine, Kuwait University, Safat, Kuwait - - 2014
We describe management and outcomes of patients with nonvalvular atrial fibrillation (AF) in the Middle East. Consecutive patients with AF presenting to emergency departments (EDs) were prospectively enrolled. Among 1721 patients with nonvalvular AF, mean age was 59 ± 16 years and 44% were women. Comorbidities were common such as ...
Bienias Piotr P Department of Internal Medicine and Cardiology with The Centre of Diagnosis and Treatment of Venous Thromboembolic Disease, The Medical University of Warsaw, Warsaw, - - 2014
Heart rate turbulence (HRT) impairment is a validated and an independent indicator of cardiovascular death. There are limited data on HRT in pulmonary hypertension (PH), so we assessed potential HRT alterations in PH, especially in relation to its severity. Thirty-three out of 41 patients were enrolled in the study aged ...
Zhang Han H the Emergency and Intensive Care Center, Fuwai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, - - 2014
There have been several studies of atrial fibrillation (AF) over the past decades; however, data from Chinese patients are scarce. The aim of the study was therefore to describe the patient characteristics, risk profile and management strategies for Chinese AF patients presenting to emergency department (ED). We conducted a prospective, ...
Heng Ee Ling EL Adult Congenital Heart Centre, Royal Brompton - - 2014
Neurohormonal activation has been demonstrated in small cross-sectional studies in congenital heart disease. Brain natriuretic peptide(BNP) levels have been shown to be elevated in repaired Tetralogy of Fallot (rTOF) patients when compared to controls. Whilst serum BNP measurement measurement has long been used in the clinical management of heart failure ...
Fent Graham G Northern General - - 2014
An incident heart failure (HF) diagnostic clinic implementing the NICE guidelines was established at Sheffield Teaching Hospitals in 2012. General Practitioners (GPs) refer patients with suspected HF and NT-pro BNP >400 pg/ml. The patients undergo ECG and echocardiography on the day of the assessment by a Consultant Cardiologist, who gives ...
Gong Hui H Division of Cardiology, Department of Medicine, Huashan Hospital of Fudan University, Shanghai 200040, P.R. - - 2014
Brain natriuretic peptide (BNP) is used as a prognostic biomarker for patients with heart failure (HF) in clinical practice, however, the correlation between BNP levels and the prognosis of HF in patients with reserved left ventricular systolic function (RLVSF) is not clear. Thus, the aim of the present study was ...
Qian Geng G Department of Cardiology, Chinese PLA General Hospital, 28 Fuxing Road, Beijing 100853, - - 2014
To investigate prognostic predictors of long-term survival of patients with cardiac amyloidosis (CA), and to determine predictive value of high-sensitivity cardiac troponin T (hs-cTnT) in CA patients. We recruited 102 consecutive CA cases and followed these patients for 5 years. We described their clinical characteristics at presentation and used a new, ...
Sokal Adam A Department of Cardiology, Congenital Heart Diseases and Electrotherapy. - - 2014
Currently cardiac resynchronization therapy (CRT) is recommended only for NYHA IV ambulatory patients. However, some recent reports showed that CRT can also be beneficial for the end-stage inotrope-dependent heart failure NYHA IV patients. In this report, we summarized results of CRT implantation in a group of eleven HF inotrope-dependent patients ...
Tsiachris Dimitris - - 2014
Hypertension (HTN) and chronic kidney disease (CKD) often coexist sharing common pathophysiological factors that both in combination and separately induce fibrotic changes in the heart provoking atrial fibrillation (AF). AF, per se, is associated with a 4- to 5-fold increased risk of stroke and a 2-fold increased risk of all-cause ...
Taneja Anil K AK Whipps Cross University Hospital, Barts Health NHS Trust, London, UK. Electronic address: - - 2014
Heart failure activates neurohormones, and elevated levels of brain natriuretic peptide (BNP) are associated with adverse outcomes. The SENIORS trial showed that nebivolol, a highly selective beta-1 antagonist with vasodilating properties, reduced the composite outcome of all cause mortality or cardiovascular hospital admissions in older patients with heart failure. We ...
Scholfield Michael M Department of Cardiology, University of South Florida, Tampa, FL. Electronic address: - - 2014
This study analyzed liver function abnormalities in heart failure patients admitted with severe acute decompensated heart failure (ADHF). A post hoc analysis was conducted using data from the Evaluation Study of Congestive Heart Failure and Pulmonary Artery Catheterization Effectiveness (ESCAPE). Liver function tests (LFTs) were measured at seven time-points from ...
McMurray John J V JJ BHF Cardiovascular Research Centre, University of Glasgow, Glasgow, Scotland, - - 2014
To describe the baseline characteristics and treatment of the patients randomized in the Prospective comparison of ARNi with ACEi to Determine Impact on Global Mortality and morbidity in Heart Failure trial (PARADIGM-HF), testing the hypothesis that the strategy of simultaneously blocking the renin-angiotensin-aldosterone system and augmenting natriuretic peptides with LCZ696 ...
Naccarelli Gerald V - - 2014
Dronedarone is an amiodarone analog that differs structurally from amiodarone in that the iodine moiety was removed and a methane-sulfonyl group was added. These modifications reduce thyroid and other end-organ adverse effects and makes dronedarone less lipophilic, with a shorter half-life. Dronedarone has been shown to prevent atrial fibrillation/flutter (AF/AFl) ...
Chanda Arijit A Bridgeport Hospital, Yale New Haven Health, Bridgeport, CT, USA, - - 2014
The relationship between obstructive sleep apnea (OSA) and increased risk for atrial fibrillation (AF) has been well established in previous studies. The relationship between OSA and silent AF is unknown. We hypothesized that patients with OSA but no known history of AF are at an increased risk for the arrhythmia ...
Pillarisetti Jayasree J Division of Cardiology-KU Cardiovascular Research Institute, University of Kansas Hospital & Medical Center, Kansas City, KS, 66195, - - 2014
Pre- and postablation atrial fibrillation (AF) brain natriuretic peptide (BNP) levels were shown to predict increased recurrence of AF following ablation. Our objective was to assess whether elevated BNP levels merely represent the presence of AF at the time of measurement or indeed the true recurrence of AF. In a ...
Kurtul Alparslan A Department of Cardiology, Ankara Education and Research Hospital, Ankara, - - 2014
Contrast-induced nephropathy (CIN) is associated with significantly increased morbidity and mortality after percutaneous coronary intervention (PCI). Patients with acute coronary syndrome (ACS) are at higher risk for CIN. N-terminal pro-brain natriuretic peptide (NT-proBNP) is closely linked to the prognosis as a strong predictor of both short- and long-term mortality in ...
Hebb Andrea L O AL Atlantic Lateral Skull Base Clinic, Division of Neurosurgery, Dalhousie University, QEII Halifax Infirmary Site, 1796 Summer Street 3006A, Halifax, NS B3H 3A7. Electronic address: - - 2014
Atrial fibrillation (A-fib) is the most common cardiac arrhythmia which is associated with an increased risk of mortality secondary to stroke and coronary artery disease. Intravenous glucocorticoid therapy (such as dexamethasone and hydrocortisone) is frequently used peri-operatively in patients undergoing cardiac surgery to prevent A-fib. Dexamethasone is also frequently used ...
Lewalter T T Isar Heart Center Munich, Munich, - - 2014
Patients with atrial fibrillation (AF) are at an increased risk of ischaemic stroke. The efficacy of stroke prevention with vitamin K antagonists in these patients has been well established. However, associated bleeding risks may offset the therapeutic benefits in patients with risk factors for bleeding. Despite improvements achieved by novel ...
Hussain Arif A Department of Pathology, Dr. Ziauddin University Hospital, North Nazimabad Campus, - - 2014
Objective: To determine the diagnostic cut-off values of brain natriuretic (BNP) peptide to establish left ventricular failure in patients presenting with dyspnoea in emergency department. Study Design: Descriptive study. Place and Duration of Study: Ziauddin University Hospital, Karachi, from July to December 2011. Methodology: BNP estimation was done on Axysm ...
Lelli D D Unit of Geriatrics, Area di Geriatria, Università Campus Biomedico di Roma, via Alvaro del Portillo 200, 00128, Rome, Italy, - - 2014
Patients with high NT-proBNP levels but without heart failure (HF) diagnosis have a higher risk of cardiovascular events and mortality; however, there are few data about their characteristic, especially in the elderly. To compare the clinical and echocardiographic characteristics of elderly hospitalized patients with and without increased NT-proBNP and with ...
Berin Roni R The Bruce and Ruth Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, - - 2014
Although high serum natriuretic peptide (NP) has long been associated with mortality prediction, it was usually tested under acute heart failure (HF) conditions and periods of analysis were short. This may explain the lack of consensus when its routine measurement for mortality prediction is contemplated. Here we evaluated, at the ...
Méndez Ana B AB Ana B Méndez, Andreu Ferrero, Mariana Noguero, Sònia Mirabet, Juan Cinca, Eulàlia Roig, Cardiology Department, Hospital de la Santa Creu i Sant Pau, Institut de Recerca Biomèdica Sant Pau and Universitat Autònoma, 08041 Barcelona, - - 2014
To study the prognostic value of carbohydrate antigen 125 (CA125) and whether it adds prognostic information to N-terminal pro-brain natriuretic peptide (NT-proBNP) in stable heart failure (HF) patients. The predictive value of CA125 was retrospectively assessed in 156 patients with stable HF remitted to the outpatient HF unit for monitoring ...
Giannakoulas George G First Cardiology Department, AHEPA Hospital, Aristotle University of Thessaloniki, St. Kyriakidi 1, 54636, Thessaloniki, Greece; Royal Brompton Biomedical Research Unit NIHR, National Heart and Lung Institute, Imperial College, London, United Kingdom. Electronic address: - - 2014
The development of pulmonary arterial hypertension (PAH) in patients with congenital heart disease (CHD) is multifactorial with a number of biomarkers serving as mediators of neurohormonal activation [B-type natriuretic peptide (BNP) and its N-terminal-pro-fragment (NT-proBNP)], endothelial dysfunction [asymmetric dimethylarginine (ADMA)] and cellular proliferation [vascular endothelial growth factor (VEGF)]. We systematically ...
De Vos Cees B CB Maastricht University Medical Centre, The Netherlands. Electronic address: - - 2014
Electrophysiological studies demonstrate that a short atrial fibrillation cycle length (AFCL) is related with poor outcome of electrical cardioversion (ECV) of atrial fibrillation (AF). We found previously that the mechanical AFCL (AFCL-tvi) and atrial fibrillatory velocity (AFV-tvi) may be determined non-invasively using color tissue velocity imaging and closely relates to ...
Medina Laura L Ramón y Cajal University Hospital, Clinical Biochemistry - - 2014
The aim of the present study was to analyze whether absolute BNP and relative BNP changes values during follow-up of elderly patients with chronic HF could predict the development of acute decompensated episodes. A total population of 108 elderly outpatients with the diagnosis of HF was retrospectively reviewed. Available BNP ...
Grygier M M st Department of Cardiology, Poznan University of Medical Sciences, Poznan, Poland - - - 2014
Remodeling and impaired blood flow in left atrial appendage (LAA), which occurs in patients with atrial fibrillation, may lead to thrombus formation and possible thromboembolic complications. Although there are several pharmacological antithrombotic possibilities, some patients with several co-morbidities and contraindications to such treatment cannot be offered any of them - ...
Makubi Abel A Cardiology Unit, Department of Medicine, Karolinska Institute, , Stockholm, - - 2014
This study aimed to describe the contemporary aetiology, clinical characteristics and mortality and its predictors in heart failure (HF) in Tanzania. Design; Prospective observational study. Setting; Cardiovascular Center of the Muhimbili National Hospital in Dar es Salaam, Tanzania. Patients ≥18 years of age with HF defined by the Framingham criteria. ...
Pietrzak A A Department of Dermatology, Venereology and Paediatric Dermatology, Medical University, Lublin, - - 2014
Apparently, these days psoriasis is regarded as a systemic disease with frequent cardiovascular comorbidities, such as hypertension, myocardial infarction, valvular defects etc., which may lead to reduced lifespan or even sudden death. Therefore, it is important that biomarkers helpful in early detection or prediction of cardiovascular complications as well as ...
Roberts Matthew A MA Department of Renal Medicine, Eastern Health Clinical School, Monash University, Victoria, Australia;, †Department of Medicine, University of Melbourne, Victoria, Australia;, ‡Department of Cardiology, and, ‖Department of Nephrology, Austin Health, Victoria, Australia, §Melbourne Pathology Service, Collingwood, Victoria, - - 2014
B-type natriuretic peptide (BNP) concentration predicts outcome in patients undergoing dialysis. Because survival and cardiovascular risk change across the CKD continuum, serial changes in BNP were compared in patients at different CKD stages and after kidney transplantation. Patients with CKD stages 3 and 4 (CKD 3-4), dialysis patients, and kidney ...
Rothe Susanne S Clinic for Cardiac Surgery, Heart Centre Leipzig, University Leipzig, Leipzig, - - 2014
Background Increased body mass index (BMI) is often found to be a risk factor for cardiac disease. However, it is unclear whether BMI also affects the gap junction remodeling process in atrial fibrillation (AF). The aim of the study was to see if BMI can influence the connexin43 (Cx43) distribution in ...
Snaedal Sunna S Division of Renal Medicine, Department of Clinical Science, Intervention and Technology, Karolinska Institutet, Stockholm, - - 2014
Background/Aims: N-Terminal pro-brain natriuretic peptide (NT-proBNP) is a predictor of cardiac events and death in the general population and in chronic kidney disease. There is limited information on how natriuretic peptides vary in dialysis patients. The aim of this study was to analyze NT-proBNP variability, factors predicting its variability and ...
Liu Hai - - 2014
The atrial fibrillation (AF) associated microRNAs (miRNAs) were found in the right atrium (RA) and left atrium (LA) from patients with rheumatic mitral valve disease (RMVD). However, most studies only focus on the RA; and the potential differences of AF-associated miRNAs between the RA and LA are still unknown. The ...
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