Search Results
Results 201 - 250 of 1640
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Wood Jeffrey - - 2013
Multiple sclerosis (MS) is a demyelinating and axonal degenerative disease of the central nervous system. It is the most common progressive neurological disorder of young adults affecting over 1 million persons worldwide. Despite the increased use of neuroimaging and other tools to measure MS morbidity, the neurological examination remains the ...
Al-Aqeedi Rafid Fayadh - - 2013
Mortality from cardiovascular disease in the Middle East is projected to increase substantially in the coming decades. The prevalence of metabolic syndrome (MS) in acute coronary syndrome (ACS) continues to raise interest, but data from the Middle East is limited, especially in non-diabetic patients. This study was conducted to ascertain ...
Suljic Enra - - 2013
Multiple sclerosis (MS) is the most common, chronic debilitating disease in young adults characterized by a wide variety of neurological symptoms and unpredictable increasing disability. Worldwide, MS affects about 2.5 million people, with a female-to-male ratio of approximately 2:1. The therapies used in the chronic treatment of MS are immune-modulating ...
Costantini Antonio - - 2013
The majority of the patients with multiple sclerosis (MS) experience fatigue. Some observations indicate that fatigue and related manifestations concomitant with MS could be associated with an intracellular mild thiamine deficiency. We recruited 15 patients with MS who also experience fatigue and assessed the severity of the fatigue using the ...
Kuan Yi-Chun - - 2013
Multiple sclerosis (MS) is less common in Asia, including Taiwan, and some characteristics of MS in Asians differ from those of Caucasians. Tumefactive brain lesion is even rarer in MS patients. To review patients with tumefactive MS and compare them with those in other studies investigating tumefactive demyelinating lesions and ...
Borghi Martina - - 2013
To investigate the presence and the nature of cognitive impairment in a large sample of patients with Multiple Sclerosis (MS), and to identify clinical and demographic determinants of cognitive impairment in MS. 303 patients with MS and 279 healthy controls were administered the Brief Repeatable Battery of Neuropsychological tests (BRB-N); ...
Möhrke Jan - - 2013
Recent studies on Multiple Sclerosis (MS) pathology mention the involvement of "tertiary B cell follicles" in MS pathogenesis. This inflammatory process, which occurs with interindividually great variance, might be a link between MS pathology and headaches. The aim of this study was to detect the prevalence of headaches and of ...
Khosoosi Niaki Mohammad Reza - - 2013
Background : Cardiovascular mortality and morbidity are high in chronic renal failure (CRF) patients. Increased dispersion of QT intervals is known to predispose to ventricular arrhythmias and sudden cardiac death. This study was conducted to assess the effect of hemodialysis (HD) on corrected QT (QTc) intervals and their dispersions (QTd) ...
Emamgholipour Solaleh - - 2013
Adipocytokines may be involved in multiple sclerosis (MS) as well as other autoimmune and inflammatory-related diseases. This study aims to compare levels of resistin, visfatin and leptin in three subgroups of MS patients with healthy subjects and also to study their relationship with Foxp3 expression and levels of several pro-inflammatory ...
Levinthal David J - - 2013
Background. Multiple sclerosis (MS) patients often suffer from gastrointestinal (GI) symptoms. However, the full extent and prevalence of such symptoms are not clearly established. Thus, we sought to define the prevalence of GI symptoms and syndromes in those with MS. Methods. 218 MS patients completed self-reported demographic and clinical data ...
Edwards Keith R - - 2013
Meningeal inflammation, including the presence of semi-organized tertiary lymphoid tissue, has been associated with cortical pathology at autopsy in secondary progressive multiple sclerosis (SPMS).  Accessible and robust biochemical markers of cortical inflammation for use in SPMS clinical trials are needed.  Increased levels of chemokines in the cerebrospinal fluid (CSF) can ...
Xia Zongqi - - 2013
To optimally leverage the scalability and unique features of the electronic health records (EHR) for research that would ultimately improve patient care, we need to accurately identify patients and extract clinically meaningful measures. Using multiple sclerosis (MS) as a proof of principle, we showcased how to leverage routinely collected EHR ...
Warabi Yoko - - 2013
Objective. Chronic inflammatory demyelinating polyneuropathy (CIDP) has been reported in patients with multiple sclerosis (MS). However, there have been limited reports of peripheral neuropathy as a complication of neuromyelitis optica (NMO). In this paper, we showed the characteristics and differences between peripheral neuropathy as a complication of MS and NMO. ...
Granberg Tobias T Department of Clinical Science, Intervention and Technology, Karolinska Institutet, Stockholm, - - 2013
The improved availability of MRI in medicine has led to an increase in incidental findings. Unexpected brain MRI findings suggestive of multiple sclerosis (MS) without typical symptoms of MS were recently defined as radiologically isolated syndrome (RIS). The prevalence of RIS is uncertain. The aim of this study was to ...
Kallweit Ulf U Department of Neurology, University Hospital Zurich, Frauenklinikstraße 26, 8091 Zurich, Switzerland ; Department of Neurology, Kamillus-Klinik, Hospitalstrasse 6, 53567 Asbach, - - 2013
Background. Fatigue in patients with multiple sclerosis (MS) is highly prevalent and severely impacts quality of life. Recent studies suggested that sleep-disordered breathing (SDB) significantly contributes to fatigue in MS. Study Objective. To evaluate the importance of routine respirography in MS patients with severe fatigue and to explore the effects ...
Ayatollahi Azin A Department of Neurology, School of Medicine, Tehran University of Medical Sciences, Tehran, - - 2013
Multiple sclerosis (MS) is a demyelinating disease which can cause many disabilities for the patient. Recent data suggests that MS patients have higher risk for osteoporosis. This study was performed to investigate if the osteoporosis prevalence is higher in MS patients and to determine the possible factors affecting bone mineral ...
Rezaali Saeed S Researcher, MS Research Center, Neuroscience institute, Sina Hospital, Tehran University of Medical Sciences AND Tehran Medical Branch, Islamic Azad University, Tehran, - - 2013
Recent studies have demonstrated controversial results and somewhat increased frequency of multiple sclerosis (MS). We reevaluated the files of MS patients from Qom Province of Iran in order to investigate the epidemiology of the disease. Demographic and clinical records of 592 MS patients were reviewed, which included; age, sex, date ...
Harirchian Mohammad Hossein MH Professor, Iranian Center of Neurological Research, Department of Neurology, School of Medicine, Tehran University of Medical Sciences, Tehran, - - 2013
Fatigue, a major cause of disability in individuals with multiple sclerosis (MS), is associated with reduced quality of life. The aim of this study was to evaluate the reliability and reproducibility of the Persian version of Modified Fatigue Impact Scale (MFIS) in Iranian patients with MS. This study included 15 ...
Ratchford John N JN Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, - - 2013
To determine the effect of clinical and radiologic disease activity on the rate of thinning of the ganglion cell/inner plexiform (GCIP) layer and the retinal nerve fiber layer in patients with multiple sclerosis (MS) using optical coherence tomography (OCT). One hundred sixty-four patients with MS and 59 healthy controls underwent ...
Peters Brian T BT Wyle Science, Technology and Engineering Group, Houston, TX, - - 2013
Dynamic visual acuity (DVA) testing may be a useful, indirect indicator of vestibulo-ocular reflex function. Previous evidence shows that acuity for 2 m targets differs little between patients and normals using a 75 ms display duration and that healthy subjects do not differ in acuity when standing and walking while ...
Thorsteinsdottir Sigrun S Department of Hematology, Roskilde Hospital, University of Copenhagen, - - 2013
The concurrence of myeloproliferative neoplasms (MPNs) and multiple sclerosis (MS) is unusual. We report five patients from a localized geographic area in Denmark with both MS and MPN; all the patients were diagnosed with MPNs in the years 2007-2012. We describe the patients' history and treatment. A potential link between ...
Cramer S P SP Functional Imaging Unit, Dept. of Diagnostics, Glostrup Hospital, University of Copenhagen, Denmark ; Dept. of Neurology, Glostrup Hospital, University of Copenhagen, - - 2013
To investigate whether blood-brain barrier (BBB) permeability is disrupted in normal appearing white matter in MS patients, when compared to healthy controls and whether it is correlated with MS clinical characteristics. Dynamic contrast-enhanced MRI was used to measure BBB permeability in 27 patients with MS and compared to 24 matched ...
Bakanidze George G Genetic Section, Department of Psychiatry and Psychotherapy, CCM, Charité University Medicine , Berlin , - - 2013
The nicotinic system is involved in the pathophysiology of schizophrenia. However, very little is known about its genetic basis and how it relates to clinical symptoms and potentially pharmacological intervention. Here, we investigated five single nucleotide polymorphisms (SNPs) [rs3826029] [rs2337506] [rs982574] [rs904952] [rs2337980] of the cholinergic nicotinic receptor gene, alpha ...
Makowski Karol K Internal Medicine and Car diology Department, Military Institute of Medicine, Warsaw, Poland. - - 2013
To evaluate the usefulness of the Holter method of sinoatrial conduction time (SACT) calculation in predicting the future occurrence of sinus node disease, and the emergence of indications for permanent pacing in patients with unexplained syncope. The study group included 218 patients (mean age 55 ± 17 years, 116 men) ...
Hatamian Hamidreza H Associate Professor, Department of Neurology, Poursina Hospital, Guilan University of Medical Sciences, Rasht, - - 2013
Although the precise etiology of multiple sclerosis (MS) is unknown, it seems that both genetic and environmental factors are important. Recent studies suggest that low serum vitamin D levels are important environmental factor in MS. The aim of this study was to compare the serum levels of vitamin D between ...
Solomon Andrew J AJ Department of Neurological Sciences, University of Vermont College of Medicine, Burlington, Vermont, United States of America. - - 2013
Rheumatologic diseases may cause neurologic disorders that mimic multiple sclerosis (MS). A panel of serum autoantibodies is often obtained as part of the evaluation of patients suspected of having MS. To determine, in light of recently revised diagnostic criteria for MS, neuromyelitis optica, and Sjogren's Syndrome, if testing for autoantibodies ...
Garg Anubhav - - 2012
BACKGROUND: -Clinicians commonly rely on automated diagnostic interpretations for initial, point-of-care identification of electrocardiogram (ECG) abnormalities. Our study goal was to investigate how one widely used computerized ECG analysis system performs in labeling prolongation of heart rate (HR)-corrected QT interval (QTc), an arrhythmia risk marker. METHODS AND RESULTS: -ECGs acquired ...
Carraro Nicola - - 2012
BACKGROUND: Recent studies suggest that alterations in the cerebrospinal venous system may play a role in multiple sclerosis (MS) and that chronic cerebrospinal venous insufficiency correlates with clinical features of MS patients. OBJECTIVES: To evaluate the vascularization of optic nerve (ONr) and measure ONe thickness by color Doppler ultrasonography in ...
Sharafaddinzadeh Naser - - 2012
BACKGROUND: Based on previous studies, Iran is located in a low risk area in terms of multiple sclerosis (MS). The objective of this study was to determine and compare the incidence, prevalence and demographic characteristics of MS in two ethnic groups of Persian and Arab over the period spanning 2009 ...
Ancona Roberta - - 2012
BACKGROUND: The aim of this study was to assess systolic left atrial (LA) reservoir function in patients with mitral stenosis (MS) using two-dimensional (2D) strain (ε) and strain rate imaging and its prognostic value in predicting atrial fibrillation (AF) at 4-year follow-up. METHODS: One hundred one asymptomatic patients with pure ...
Romaní Jorge - - 2013
Psoriasis has been related to metabolic syndrome (MS). Adipocytokines produced by white adipose tissue may be involved in the pathogenesis of psoriasis and its association with MS. Our objectives were to characterize the profile of a number of different inflammatory and atherogenic markers, vitamins, adipokines and cytokines and their potential ...
Adamec Ivan - - 2012
BACKGROUND: The aim of this study was to determine if there is a difference in the frequency of postural orthostatic tachycardia syndrome (POTS) in patients with multiple sclerosis (MS) compared to patients with symptoms of orthostatic intolerance and with no evidence of MS or other neurological illness. METHODS: We analyzed ...
Rojas J I - - 2012
INTRODUCTION: Previous studies showed gender-associated clinical and MRI differences in multiple sclerosis (MS) evolution. However, only few studies were done with non conventional MRI techniques and no one was done in a South American MS population. The aim of this study was to investigate gender differences according to nonconventional MRI ...
Sternberg Z - - 2012
Background: Inflammation is known to play a role in cererovascular (CV) risk. Multiple sclerosis (MS) is a neurodegenerative disease that is initially characterized by inflammatory changes in the brain. We hypothesized that due to chronic inflammation, MS patients would present with a higher levels of CV risk factors than non-MS ...
Tipirneni Anita - - 2012
PURPOSE: To investigate the MRI characteristics in a large cohort of multiple sclerosis (MS) patients with and without a family history of MS. METHODS: Enrolled in this prospective study were 758 consecutive MS patients (mean age 46.2 ± 10.1 years, disease duration 13.6 ± 9.2 years and EDSS 3.4 ± ...
Dinkin Marc - - 2012
In the evaluation of patients with multiple sclerosis (MS), optical coherence tomography (OCT) is gaining traction as a tool to assess thinning of the retinal nerve fiber layer (RNFL) and, more recently, for looking at total macular volume (TMV) thickness, with both measures used as potential biomarkers for progression of ...
Carrai Valentina - - 2012
OBJECTIVE: Recently autologous haematopoietic stem cell transplantation (AHSCT) has been introduced for the treatment of severe forms of multiple sclerosis (MS). As little data are available on bone marrow (BM) of MS patients undergoing AHSCT, we investigated the morphological and phenotypic characteristics of MS BM. METHODS: BM biopsies of 14 ...
Shang Ying-Ying - - 2012
The cochlear hydrops analysis masking procedure (CHAMP) is a new diagnostic technique for Meniere's disease (MD). But its value has not been well proven. This study aimed to evaluate the diagnostic value of CHAMP for MD. CHAMP test was taken in three populations using the Auditory Evoked Potential system delivered ...
Corrado E - - 2012
The metabolic syndrome (MS) is associated with increased cardiovascular and cerebrovascular risk. This study aimed to compare the difference of the three established diagnostic criteria of MS, developed by Adult Treatment Panel III (ATP III), American Heart Association (AHA) and National Heart Lung and Blood Institute (NHLBI), and International Diabetes ...
Mesliniene Sandra - - 2012
Objective: To review and assess the role of vitamin D on the onset, progression and relapse of multiple sclerosis (MS), based on evidence acquired from the analysis of preclinical, observational and interventional studies.Methods: All English language literature in MEDLINE (January 1969-April 2012) was searched for observational and interventional studies on ...
Romme Christensen Jeppe - - 2012
BACKGROUND: The mechanism underlying disease progression in progressive multiple sclerosis (MS) is uncertain. Pathological studies found widespread inflammation in progressive MS brains correlating with disease progression and axonal damage. OBJECTIVES: To study cerebrospinal fluid (CSF) biomarkers and clarify whether inflammation and axonal damage are associated in progressive MS. METHODS: Using ...
Ben-Fredj Nadia - - 2012
Human herpesvirus 6 (HHV-6) has been linked to the pathogenesis of multiple sclerosis (MS). Based on antibody detection and quantitative HHV-6 polymerase chain reaction assay, this study aimed to analyze the possible association between infection with HHV-6 and MS. A total of 131 serum samples were analyzed by ELISA for ...
Scalise F - - 2012
OBJECTIVES: Chronic cerebrospinal venous insufficiency (CCSVI) is a malformative condition characterized by several anomalies of the azygos and/or internal jugular veins (IJVs). Recommended diagnosis of CCSVI is performed with colour-Doppler (CD) sonography. Though catheter venography (CV) is considered as the gold standard for determining vascular anatomy, its uniplanar point of ...
Yu Fei - - 2012
Fatigue is reported as the most common symptom by patients with multiple sclerosis (MS). The physiological and functional parameters related to fatigue in MS patients are currently not well established. A new wearable wireless body measurement system, named Fatigue Monitoring System (FAMOS), was developed to study fatigue in MS. It ...
Harding Katharine E - - 2012
BACKGROUND: Age of onset of multiple sclerosis (MS) peaks in the 3rd and 4th decades and is rarely less than 18. Robust longitudinal studies in paediatric-onset MS (POMS) are limited, and a clearer understanding of outcome could optimise management strategies. METHODS: Patients with disease onset <18 years were identified from ...
Bacaksiz Ahmet - - 2013
Psoriasis vulgaris is one of the most common skin disorders. Patients with psoriasis carry an excessive risk of atrial fibrillation (AF). The differences between the maximum (Pmax) and the minimum (Pmin) P-wave duration on ECG are defined as P-wave dispersion (PWD). Prolongation of PWD is an independent risk factor for ...
Yongjun Qian - - 2012
BACKGROUND: The prevalence of atrial fibrillation (AF) and the frequency cardioversion of AF postoperatively are different in different forms of mitral valve disease. We hypothesized that these differences would relate to different extent of histopathological characteristics and oxidative injury in different forms of mitral valve diseases. METHODS: Left atrial appendages ...
Van den Berg P J - - 2012
BACKGROUND: A new treatable venous disorder, chronic cerebrospinal venous insufficiency (CCSVI), has been proposed in patients with multiple sclerosis (MS). Its relationship with iron metabolism is suggested, but has not been examined prospectively. METHODS: We performed extra- and transcranial echo colour Doppler (ECD) in 90 patients with MS and 41 ...
Bender Matthew T - - 2012
Object Patients with trigeminal neuralgia due to multiple sclerosis (TN-MS) and idiopathic TN (ITN) who underwent glycerol rhizotomy (GR) and radiofrequency thermocoagulation with glycerol rhizotomy (RFTC-GR) were compared to investigate the effectiveness of these percutaneous ablative procedures in the TN-MS population. Methods Between 1998 and 2010, 822 patients with typical ...
Wu Aimin - - 2012
Background: Neuromyelitis optica (NMO) and multiple sclerosis (MS) are inflammatory demyelinating diseases of human central nervous system (CNS) with complex pathogenesis. IL-21/IL-21R regulates activation, proliferation and survival of both T cells and B cells, which are involved in the pathogenesis of NMO and MS. High levels of serum IL-21 were ...
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