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Zecca C C Department of Neurology, Neurocenter of Southern Switzerland, Ospedale Regionale, Lugano, - - 2014
Fumaric acid esters (FAEs) are effective in patients with moderate to severe psoriasis. Recent studies also report the efficacy of one FAE component, dimethylfumarate, in relapsing forms of multiple sclerosis (MS). We describe the case of a patient with MS who developed severe plaque psoriasis during interferon-β-1a treatment for MS. ...
Ropele Stefan S Medical University of Graz, Auenbruggerplatz 22, 8036 Graz, - - 2014
Iron accumulation in deep grey matter (GM) structures is a consistent finding in multiple sclerosis (MS) patients. This study focused on the identification of independent determinants of iron accumulation using R2* mapping. Ninety-seven MS patients and 81 healthy controls were included in this multicentre study. R2* mapping was performed on ...
Khalil M M Medical University of Graz, Auenbruggerplatz 22, A-8036 Graz, - - 2014
Previous magnetic resonance imaging (MRI) studies have demonstrated increased iron deposition in the basal ganglia of multiple sclerosis (MS) patients. However, it is not clear whether these alterations are associated with changes of iron metabolism in body fluids. The purpose of this study was to investigate if iron metabolism markers ...
Ceccato Filippo F F Ceccato, Department of Medicine DIMED, University-Hospital of Padova, Endocrinology Unit, Padova, - - 2014
The Endocrine Society Clinical Guidelines recommend measuring 24h urinary free cortisol (UFF) using a highly accurate method as one of the first-line screening tests for the diagnosis of Cushing's Syndrome (CS). We evaluated the performance of UFF, urinary free cortisone (UFE), and the UFF/UFE ratio, measured using a liquid chromatography-tandem ...
Demirel Aysegul A Department of Psychiatry, Cerrahpaşa Faculty of Medicine, Istanbul University, Turkey. Electronic address: - - 2014
The use of atypical antipsychotic drugs in patients with psychiatric illness may result in dyslipidemia, hypertension, glucose intolerance, and abdominal obesity, which are together referred to as metabolic syndrome (MS). To investigate any correlations among insulin-like growth factor-1 (IGF-1), schizophrenia, and MS, we examined the metabolic profiles of patients with ...
Amorini Angela M AM Institute of Biochemistry and Clinical Biochemistry, Catholic University of Rome, Largo F. Vito 1, 00168 Rome, Italy. Electronic address: - - 2014
Multiple sclerosis (MS) is a primary inflammatory demyelinating disease associated with a probably secondary progressive neuronegenerative component. Impaired mitochondrial functioning has been hypothesised to drive neurodegeneration and to cause increased anaerobic metabolism in MS. The aim of our multicentre study was to determine whether MS patients had values of circulating ...
Torres do Rego Ana A Cardiovascular Risk and Lipid Unit, Instituto de Investigaciones Sanitarias, Hospital General Universitario Gregorio Marañón, Facultad de Medicina, Universidad Complutense Madrid, Red Investigación Cardiovascular (RIC), RD12/0042/0033, Instituto de Salud Carlos III, - - 2014
Metabolic syndrome (MS) is an association of cardiovascular risk factors that increases the risk of coronary disease or type 2 diabetes mellitus (DM2), and has also been associated with the presence of liver steatosis (LS). In this study the relation of MS and LS with cholesterol control was analyzed in ...
Kallaur A P AP Health Sciences Postgraduate Program, Health Sciences Center, State University of Londrina, Londrina, Paraná, Brazil, - - 2014
This study evaluated the association of tumor necrosis factor beta (TNF-β) NcoI polymorphism with the presence of multiple sclerosis (MS), disability, and HLA-DRB1 alleles in 208 Brazilian MS patients. As controls, 147 healthy individuals were included. The disability was evaluated at baseline and 5-year follow-up using the Expanded Disability Status ...
González-Senac Nicolás M NM a Division of Internal Medicine, Metabolic-Vascular Unit , La Paz University - - 2014
Background and Objectives. Primary gout has traditionally been associated with obesity, arterial hypertension, and abnormal lipid and glucose homeostasis, but we do not know the prevalence of these vascular risk factors in patients with primary gout from a Mediterranean country. Patients and Method. All patients with primary gout and 2 ...
Warntjes J B M JB From the Center for Medical Image Science and Visualization, (J.B.M.W., A.T., P.L.) and Clinical Physiology (J.B.M.W.) and Radiation Physics (P.L.), Department of Medical and Health Sciences, Linköping University, Linköping, Sweden; Departments of Clinical Physiology (J.B.M.W.), Clinical Neuroscience (A.-M.L.), and Radiation Physics (P.L.), UHL, County Council of Östergötland, Linköping, Sweden; Radiation Physics (A.T.), Department of Medical and Health Sciences, Faculty of Health Sciences, Linköping University, Linköping, Sweden; and Neurology, Department of Clinical and Experimental Medicine (A.-M.L.), Linköping University, Linköping, - - 2014
The administration of gadolinium contrast agent is a common part of MR imaging examinations in patients with MS. The presence of gadolinium may affect the outcome of automated tissue classification. The purpose of this study was to investigate the effects of the presence of gadolinium on the automatic segmentation in ...
Lakshmi Sristi S Department of Dermatology, Indira Gandhi Medical College and Research Institute, Puducherry, - - 2014
Psoriasis patients are at increased risk of developing the metabolic syndrome (MS). Proinflammatory cytokines such as tumor necrosis factor-α, interleukin-6 that are increased in the psoriatic plaques are known to contribute to features of MS such as hypertension, dyslipidemia and insulin resistance. (1) To establish the frequency of MS in ...
Cappelli Carlo C Department of Medical and Surgical Sciences, Endocrine and Metabolic Unit, University of Brescia; - - 2014
Metformin treatment may induce a decrease/suppression in serum TSH levels, mimicking sub-clinical hyperthyroidism (SHT). The aim of the present study was to retrospectively evaluate changes in several electrocardiographic indices in euthyroid subjects with diabetes who, after starting metformin treatment, developed a low serum TSH as compared to patients with SHT ...
Spagnolo Salvatore S Department of Cardiac and Vascular Surgery, Policlinico di Monza, Monza, Italy; Cardiac and Vascular Catheterization Laboratory, Policlinico di Monza, Monza, Italy; CCSVI Research Center, Policlinico di Monza, Monza, - - 2014
Chronic cerebrospinal venous insufficiency (CCSVI) is a vascular condition characterized by morphological alterations involving efferent cerebral vascular paths. CCSVI has been implicated as a contributing factor to multiple sclerosis (MS) but this theory is highly controversial. We report three cases of CCSVI patients with MS who had undergone internal jugular ...
Sawalhi Samer S From the *Department of Surgery, College of Medicine, Taibah University; †Department of Radiology, King Fahd Hospital; ‡Medical Laboratory Department, College of Applied Medical Sciences, Taibah University; and §Department of Surgery, Al-Ansar Hospital, Al Madina, Saudi - - 2014
The incidence of acute pancreatitis (AP) is rising with increased prevalence of obesity, which exacerbates pancreatic injury. Metabolic syndrome (MS) is defined as a cluster condition of cardiovascular risk factors, including hyperglycemia, dyslipidemia, hypertension, and central obesity. We analyze if the presence of obesity and/or MS affects the course of ...
Charlebois Kathleen K 1.Centre de recherche de l'Hôpital Charles LeMoyne, Université de Sherbrooke, Québec, - - 2014
Malgré un vif intérêt pour la participation des patients à la gestion et à la prestation des soins de santé primaires, il n'existe aucune revue de la littérature sur le rôle des personnes vulnérables dans les projets de recherche participative menés dans le domaine des soins primaires. Une revue de ...
Jahromi Soodeh Razeghi - - 2014
Month-long daytime Ramadan fasting pose s major challenges to multiple sclerosis (MS) patients in Muslim countries. Physicians should have practical knowledge on the implications of fasting on MS. We present a summary of database searches (Cochrane Database of Systematic Reviews, PubMed) and a mini-symposium on Ramadan fasting and MS. In ...
Okumura Yuka Y Department of Clinical Brain Sciences, Chubu Medical Center for Prolonged Traumatic Brain Dysfunction, Kizawa Memorial Hospital, Gifu University Graduate School of Medicine , Minokamo, Gifu , - - 2014
Abstract Objective: The aim of this study was to objectively evaluate the brain activity potential of patients with impaired consciousness in a chronic stage of diffuse brain injury (DBI) using functional MRI (fMRI) following music stimulation (MS). Methods: Two patients in a minimally conscious state (MCS) and five patients in ...
Nikseresht Alireza A Shiraz University of Medical Sciences, Shiraz, - - 2014
Multiple sclerosis (MS) is the most common chronic autoimmune demyelinating disease of the central nervous system. The purpose of this study is to determine the relationship between the site of the cervical discopathy and cervical spinal cord plaque in MS patients. This retrospective study included all patients with a definite ...
De Bock Muriel M GIGA Research (GIGA-I³, GIGA-cancer, and GIGA-Neuroscience), University of Liège, CHU, B36, B-4000 Liège, - - 2014
Acute graft-versus-host disease (aGVHD) remains a life-threatening complication of hematopoietic stem cell transplantation (HSCT) therefore limiting its application. To optimize the management of aGVHD and reduce therapy-related toxicity, early specific markers are needed. The main objective of this study was to uncover diagnostic biomarkers by comparing plasma protein profiles of ...
Niino Masaaki M Department of Clinical Research, Hokkaido Medical Center, Sapporo, Japan. Electronic address: - - 2014
We investigated whether calcitriol (1,25-dihydroxyvitamin D) differentially modulates cytokine production by peripheral blood mononuclear cells from multiple sclerosis (MS) patients compared with that from healthy controls. In response to phytohemagglutinin (PHA) or lipopolysaccharide (LPS), cytokine level in a calcitriol-added sample was normalized to that in a calcitriol-absent sample, and this ...
Eaton L H LH Faculty of Life Sciences, The University of Manchester, Manchester, United - - 2014
An episode of guttate psoriasis can be: an isolated event, recur as guttate episodes, or develop into chronic plaque psoriasis (CPP). A previous study, revealed that early-onset (before age 40y) CPP is associated with inhibition of epidermal Langerhans' cell (LC) migration. To determine whether guttate psoriasis is also associated with ...
Bruno E E Section of Neurosciences, Department GF Ingrassia, University of Catania, Catania, - - 2014
A population-based case-control study in the city of Catania, Sicily, was carried out to determine restless legs syndrome (RLS) prevalence and its association with multiple sclerosis (MS). Patients were randomly selected from a cohort of MS patients resident in the study area and a group of age and sex matched ...
Igeta Hirofumi H Department of Psychiatry, Niigata University Graduate School of Medical and Dental Sciences, Niigata, - - 2014
Although several case reports suggested that donepezil hydrochloride can induce bradycardia or atrioventricular block, the details remain unclear. We implemented a study of the impact of donepezil hydrochloride administration on PR, RR, and QT intervals. The subjects were 18 patients who were diagnosed with either dementia or cognitive disorder (DSM-IV-TR) ...
Thelen Joanie M JM Department of Psychology, University of Missouri - Kansas City, Kansas City, MO, United - - 2014
Patients with multiple sclerosis (MS) commonly use a variety of medications to slow disease progression, alleviate symptoms, and treat comorbid conditions. Polypharmacy has been linked to adverse outcomes in other patient groups, but has not been studied extensively in MS. We investigated the impact of polypharmacy on fatigue, objective neuropsychological ...
Glasnović Anton A Department of Physiology and Immunology, University of Zagreb School of Medicine, Zagreb, - - 2014
Objectives: Receptor for advanced glycation end products (RAGE) ligands/RAGE interactions have been proposed to have a pathogenic role in neuroinflammatory disorders. Our study aimed to assess changes in high-mobility group box (HMGB)1 and its receptor RAGE in peripheral blood (PBL) and cerebrospinal fluid (CSF) of patients with multiple sclerosis (MS) ...
Reuss Reinhard R Department of Neurology, Bezirkskrankenhaus Bayreuth, Bayreuth, - - 2014
Objective: To elucidate the role of tumor necrosis factor (TNF) receptor signal transduction in multiple sclerosis (MS). Methods: We performed a cross-sectional analysis of the gene expression of TNF receptor-associated death domain protein (TRADD) and Fas-associated death domain protein (FADD) in peripheral blood leukocytes of 23 relapsing remitting (RR), 19 ...
Lapuente Torrents Ana - - 2014
Comorbidities of OSA PostersSESSION TYPE: Poster PresentationsPRESENTED ON: Saturday, March 22, 2014 at 01:15 PM - 02:15 PMPURPOSE: The aim of our study was to determine the relationship between some inflammatory mediators, Obstructive Sleep Apnea (OSA) and the Metabolic Syndrome (MS). A total of 140 patients with clinical suspicion of ...
Oliveira Sayonara Rangel SR Postgraduate Program, Health Sciences Center, State University of Londrina, Paraná, - - 2014
The aims of the present study were to report the prevalence of insulin resistance (IR) in patients with multiple sclerosis (MS); to verify differences in metabolic and inflammatory biomarkers, and oxidative stress in patients with MS with or without IR; and to assess if IR and adiposity are associated with ...
Hesse Swen S Department of Nuclear Medicine, University of Leipzig, Liebigstraße 18, 04103, Leipzig, Germany, - - 2014
Modulation of the immune system by the CNS may involve serotonergic regulation via the brain serotonin transporters (SERT). This regulation may be disturbed in patients with CNS disorders including multiple sclerosis (MS). Central serotonergic mechanisms have not been investigated in MS by in vivo imaging. The objective of the study ...
Pavlova Milena M Division of Epilepsy, Neurophysiology, and Sleep, Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA. Electronic address: - - 2014
Differentiating between epileptic seizures (ES) and seizure-like nonepileptic events (SLNE) is often difficult using descriptions of seizure semiology. Cardiopulmonary dysfunction is frequent in ES but has not been objectively examined in relation to SLNE. Our purpose was to compare cardiopulmonary dysfunction between ES and SLNE. We prospectively recorded cardiopulmonary function ...
Oh Jiwon J From the Department of Neurology (J. Oh, S.S., P.A.C., S.D.N.), Johns Hopkins University, Baltimore; and Neuroimmunology Branch (I.C., J. Ohayon, B.B.), National Institute of Neurological Disorders and Stroke, Bethesda, - - 2014
To report 3 patients with multiple sclerosis (MS) who presented with daclizumab-related adverse events (AEs) in multiple organ systems. A retrospective chart review was performed of patients with MS who had clinical and histopathologic findings suggestive of daclizumab-induced AEs between 2004 and 2010 at the Johns Hopkins MS Clinic. This ...
Balood Mohammad M Department of Clinical Biochemistry, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, - - 2014
A plethora of studies have shown that lysophosphatidic acid (LPA) is involved both in inflammation and T cell apoptosis evasion. The aim of this study was to measure the concentrations of LPA in serum of patients with multiple sclerosis (MS). Twenty MS patients along with 20 age-sex matched healthy individuals ...
Rietberg Marc B MB 1Department of Rehabilitation Medicine, MOVE Research Institute Amsterdam, VU University Medical Center, Amsterdam, The - - 2014
. Reduced physical activity is an important consequence of multiple sclerosis (MS). However, little is known about the real quantity and type of daily activities that people with MS perform in their own home environment. To gain insight into differences in the amount and patterns of physical activities performed over ...
Lim Young-Min YM Department of Neurology, Asan Medical Center, University of Ulsan College of Medicine, 88, Olympic-Ro 43-Gil Songpa-Gu, Seoul, 138-736, Republic of - - 2014
To identify factors distinguishing subsequent neuromyelitis optica (NMO) from multiple sclerosis (MS) after first-ever optic neuritis (ON), we compared ophthalmic findings and MRI features of 24 NMO and 55 MS patients who initially presented with ON. The female-to-male ratio was higher, and bilateral ON was more common in NMO patients ...
Cioffi Giovanni G Department of Cardiology, Villa Bianca Hospital, Trento, Italy. Electronic address: - - 2014
In this study, we tested the hypothesis that impaired midwall shortening predicts cardiovascular (CV) mortality in patients with type 2 diabetes mellitus (DM). In patients with DM without overt cardiac disease, systolic left ventricular (LV) function analyzed by midwall shortening may be impaired although LV ejection fraction is preserved. Impaired ...
Kalay Nihat N Department of Cardiology, Erciyes University Medical Faculty, Kayseri, - - 2014
The role of hyaluronan (HA) was previously demonstrated in patients with idiopathic pulmonary arterial hypertension (PAH). Mitral stenosis (MS) and pulmonary arterial thromboembolism (PTE) are important health problems that can cause pulmonovascular pathology. Pulmonary arterial hypertension develops especially in untreated patients with severe MS and most of patients with PTE. ...
Zito Giancarlo G Laboratory of Electrophysiology for Translational neuroScience (LET'S), ISTC, Consiglio Nazionale delle Ricerche, 'S. Giovanni Calibita' Fatebenefratelli Hospital, Rome I-00186; Department of Clinical Neuroscience, AFaR, 'San Giovanni Calibita' Fatebenefratelli Hospital, Rome, I-00186. Electronic address: - - 2014
Multiple sclerosis (MS) affects myelin sheaths within the central nervous system, concurring to cause brain atrophy and neurodegeneration as well as gradual functional disconnections. To explore early signs of altered connectivity in MS from a structural and functional perspective, the morphology of corpus callosum (CC) was correlated with a dynamic ...
Liu Hai - - 2014
Structural changes of the left and right atria associated with atrial fibrillation (AF) in mitral stenosis (MS) patients are well known, and alterations in microRNA (miRNA) expression profiles of the right atria have also been investigated. However, miRNA changes in the left atria still require delineation. This study evaluated alterations ...
Alkhouri Naim N Department of Gastroenterology and Hepatology, Digestive Disease Institute, Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH, 44195, USA, - - 2014
Oxidative stress is a core abnormality responsible for disease progression in nonalcoholic fatty liver disease (NAFLD). By employing a highly sensitive liquid chromatography-tandem mass spectrometry (LC/MS/MS) approach we recently were able to define the circulating profile of bioactive lipid peroxidation products characteristic of patients with nonalcoholic steatohepatitis (NASH) and developed ...
Alroughani R R Division of Neurology, Department of Medicine, Amiri Hospital, Sharq, Kuwait; Neurology Clinic, Department of Medicine, Dasman Diabetes Institute, Dasman, Kuwait. Electronic address: - - 2014
Post-marketing studies are important to confirm what was established in clinical trials, and to assess the intermediate and long-term efficacy and safety. To assess efficacy and safety of fingolimod in multiple sclerosis (MS) in Kuwait. We retrospectively evaluated MS patients using the MS registries in 3 MS clinics. Relapsing remitting ...
Jarčuška Peter P 1st Department of Internal Medicine, Pavol Jozef Šafárik University in Košice, Trieda SNP 1, 04001 Košice, Slovakia. Electronic address: - - 2014
The presence of hepatitis B infection (HBI) and metabolic syndrome (MS) at the same time constitutes a high risk for liver cirrhosis and potentially hepatocellular carcinoma. In this study we aim to explore the relationship between MS and HBI. We used data from the cross-sectional HepaMeta study conducted in 2011 ...
Ciftel Murat M Department of Pediatric Cardiology, Erzurum Region Training and Research Hospital, Erzurum, Turkey, - - 2014
Right ventricular (RV) dysfunction, pulmonary hypertension, atrial enlargement, and cor pulmonale may be associated with asthma. These pathological conditions may disturb the electrophysiological properties of the right atrium. This study investigated the atrial electromechanical delay and P-wave dispersion (PWD) in patients with asthma. Thirty-four children aged 8-16 years who were ...
Badawy Radwa A B RA Departments of Medicine and Electrical and Electronic Engineering, The University of Melbourne, Parkville, Victoria 3010, Australia , Department of Clinical Neurosciences, St Vincent's Hospital, 41 Victoria Parade Fitzroy, Victory 3065, - - 2014
Paired pulse transcranial magnetic stimulation was used to investigate differences in cortical excitability between patients with isolated (unrecurrent, unprovoked) seizures and those with epilepsy. Compared to controls, cortical excitability was higher in the isolated seizure group at 250-300 ms. Compared to epilepsy, cortical excitability was lower in patients with isolated ...
Espinosa-Ramírez Guillermo - - 2014
Objective: We analysed past and current sun exposure in multiple sclerosis (MS) patients as compared with matched controls in Mexico, a country with tropical climate. Methods: In a case-controlled study that include 83 MS patients and 166 matched controls, we inquired about sunlight exposure on two different periods: during adolescence ...
Freedman Mark S MS Department of Medicine, University of Ottawa, 501 Smyth Road, Ottawa, ON, K1H 8L6, Canada, - - 2014
The REFLEX study (NCT00404352) established that subcutaneous (sc) interferon (IFN) β-1a reduced the risks of McDonald MS (2005 criteria) and clinically definite multiple sclerosis (CDMS) in patients with a first clinical demyelinating event suggestive of MS. The aim of this subgroup analysis was to assess the treatment effect of sc ...
Fellner Avi A Department of Neurology Belinson Hospital, Rabin Medical Center (AF), - - 2014
MS and psoriasis are both autoimmune diseases putatively mediated mainly by T cells. We conducted a case control study to investigate whether patients with MS have a high rate of comorbid psoriasis. The cohort consisted of 214 consecutive MS patients and a control group of 192 consecutive patients with headache. ...
Weigel Kelsey J - - 2014
Histochemical and MRI studies have demonstrated that multiple sclerosis (MS) patients have abnormal deposition of iron in both gray and white matter structures. Data is emerging indicating that this iron could partake in pathogenesis by various mechanisms, e.g., promoting the production of reactive oxygen species and enhancing the production of ...
Kuračka Lubomír L Institute of Medical Chemistry, Biochemistry and Clinical Biochemistry, Faculty of Medicine, Comenius University, 811 08 Bratislava, - - 2014
In the pathogenesis of demyelinating diseases including multiple sclerosis (MS) an important role is played by oxidative stress. Increased energy requirements during remyelination of axons and mitochondria failure is one of the causes of axonal degeneration and disability in MS. In this context, we analyzed to what extent the increase ...
Cavallari Michele M Center for Neurological Imaging, Department of Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America; Dipartimento di Neuroscienze, Salute Mentale e Organi di Senso (NESMOS), Università La Sapienza, Rome, - - 2014
Grey matter (GM) damage is a clinically relevant feature of multiple sclerosis (MS) that has been previously assessed with diffusion tensor imaging (DTI). Fractional anisotropy (FA) of the basal ganglia and thalamus might be increased in MS patients, and correlates with disability scores. Despite the established role of the striatum ...
Wang Kai-Chen KC Department of Neurology, Cheng Hsin General Hospital, Taipei, Taiwan; Neurological Institute, Taipei Veterans General Hospital, Taipei, Taiwan; National Yang-Ming University, School of Medicine, Taipei, - - 2014
Interferon-beta (IFN-β) treatment may not be effective in neuromyelitis optica (NMO). Whether the poor response to IFN-β is related to long spinal cord lesions (LSCL) or the NMO disease entity itself is unclear. We evaluated the spinal cord involvement of patients with multiple sclerosis (MS) and NMO, as well as ...
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