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Park Susanna B SB Institute of Neurology, University College London, United Kingdom; Prince of Wales Clinical School & Neuroscience Research Australia, University of New South Wales, - - 2014
Although autoantibodies targeted against voltage-gated potassium channel (VGKC)-associated proteins have been identified in limbic encephalitis (LE) and acquired neuromyotonia (aNMT), the role of these antibodies in disease pathophysiology has not been elucidated. The present study investigated axonal function across the spectrum of VGKC-complex antibody associated disorders. Peripheral axonal excitability studies ...
Blom Marieke T MT 1Heart Center, Academic Medical Center, University of Amsterdam, Amsterdam, the - - 2014
-The causes of the increased risk of sudden cardiac death (SCD) in schizophrenia are not resolved. We aimed to establish whether 1) ECG markers of SCD-risk, in particular, Brugada-ECG pattern, are more prevalent among schizophrenia patients, 2) increased prevalence of these ECG markers in schizophrenia is explained by confounding factors, ...
Mints Yuliya Y The Johns Hopkins University School of Medicine, Baltimore, - - 2014
Atrial fibrillation (AF) is the most common form of cardiac arrhythmia. Despite significant progress in identification of predisposing factors, the pathophysiology of AF remains to be elucidated. Previous studies have reported that single nucleotide polymorphisms (SNPs) in potassium-channel genes associate with AF and the instantaneous corrected QT interval (QTc). The ...
Ghoraani B - - 2013
In humans, the existence of rotors or reentrant sources maintaining AF and the underlying electroanatomic substrate has not been well defined. Our objective was to determine the prevalence of localized rotational activation (RotA) in the left atrium (LA) during human AF and whether CFAEs or low voltage areas co-localize with ...
Malloy Lindsey - - 2013
Voltage guidance for the ablation of the slow pathway in atrioventricular nodal reentry tachycardia (AVNRT) is a dramatic shift from the traditional anatomy-guided approach within the triangle of Koch. The use of voltage gradient mapping has been evaluated in adults as an aid to identification of the slow pathway guiding ...
Ferlazzo Edoardo - - 2013
We used permutation entropy (PE) to disclose abnormalities of cerebral activity in patients with typical absences (TAs). We evaluated 24 EEG of TA patients and 40 EEG of healthy subjects. PE was estimated channel by channel, with electrodes being divided into high-PE cluster (high randomness), low-PE cluster (low randomness), and ...
Peng Hong - - 2013
Abnormalities in schizophrenia are thought to be associated with functional disconnections between different brain regions. Most previous studies on schizophrenia have considered high-band connectivity in preference to the Alpha band, as there has been some uncertainty correlating the latter to the condition. In this paper we attempt to clarify this ...
Molteni Erika - - 2013
Near Infrared Spectroscopy (NIRS) was employed for the detection of possible residual functional activations in two patients in minimally conscious state. An "ad hoc" protocol for somatosensory and motor stimulations was created and administered to the patients, synchronously to NIRS recordings. One healthy subject was also assessed with the same ...
Horaguchi Jun - - 2013
BACKGROUND: Pancreatobiliary reflux (PBR) can occur in individuals without pancreaticobiliary maljunction. The aim of this study was to elucidate the incidence of PBR in individuals with a normal pancreaticobiliary junction and its impact on the biliary tree. METHODS: Data were prospectively collected from 15 centers on 420 patients with a ...
Cheng Christopher K - - 2013
We report a patient who recently had a liver transplant presented with increasing confusion and intermittent hallucinations. MRI of the brain revealed diffuse left temporal and parietal lobe swelling with cortical diffusion restriction suggestive of possible infectious aetiology, although stroke was also possible given the presence of left posterior cerebral ...
Bürk Katrin - - 2012
Abstract We report a female patient of German descent with a molecular diagnosis of SCA13 who presented with a history of cerebellar ataxia and epilepsy. The underlying mutation R420H had been shown to cause a dominant negative effect on the functional properties of the voltage-gated potassium channel KCNC3. Despite widespread ...
Zijlmans Maeike - - 2012
Purpose:  Epileptic high-frequency oscillations (HFOs; 80-500 Hz) may be used to guide neurosurgeons during epilepsy surgery to identify epileptogenic tissue. We studied the effect of the anesthetic agent propofol on the occurrence of HFOs in intraoperative electrocorticography (ECoG). Methods:  We selected patients who were undergoing surgery for temporal lobe epilepsy with ...
Sant'anna Thaís - - 2012
OBJECTIVE: To assess the criterion validity and reproducibility of the Power Walker 610 motion sensor (PW) in patients with chronic obstructive pulmonary disease (COPD). DESIGN: Cross-sectional study. SETTING: Outpatient Physiotherapy Clinic from an University Hospital. PARTICIPANTS: Thirty patients with COPD (17 male, FEV(1) 44±17%pred) were videotaped while performing two protocols: ...
Fujishiro Hirofumi - - 2011
BACKGROUND: The prevalence of eosinophilic esophagitis (EE) is increasing rapidly in Western countries. Several case series of EE have also been reported in Japan. However, the prevalence of EE in Japanese patients as investigated by upper gastrointestinal endoscopy is unknown. Therefore, we carried out a prospective multicenter study to address ...
Gartzen K - - 2011
To investigate possible peripheral nervous system (PNS) affection in patients with multiple sclerosis (MS) by standard nerve conduction velocity (SNC) and pain-related evoked potentials (PREP), a novel electrophysiological method for diagnosing small fibre neuropathy. Former neuropathological and electrophysiological studies demonstrated subtle PNS affection in MS, but routine measurements are mostly ...
Arnold Paul M - - 2011
A case series of 15 patients. To report a series of patients with coexisting multiple sclerosis (MS) and progressive myeloradiculopathy who were successfully treated with surgical decompression, fusion, and fixation. MS and cervical myeloradiculopathy share clinical signs, including gait dysfunction, motor weakness, and hyperreflexia. Distinguishing between these 2 entities may ...
Gray Charnelda L - - 2011
Purpose The pharmacology, pharmacokinetics, clinical efficacy, and safety of febuxostat are reviewed. Summary Febuxostat is a novel non-purine selective inhibitor of xanthine oxidase for the management of hyperuricemia in patients with gout. The ability of febuxostat to decrease serum uric acid production through selective inhibition of enzyme xanthine oxidase has ...
Burman J - - 2011
Burman J, Raininko R, Fagius J. Bilateral and recurrent optic neuritis in multiple sclerosis. Acta Neurol Scand: 2011: 123: 207-210. © 2010 John Wiley & Sons A/S. Objective -  To assess the frequency of bilateral and recurrent optic neuritis (ON) in multiple sclerosis (MS) and to compare these results with epidemiological ...
Liao M F - - 2011
Background:  Patients with acute disseminated encephalomyelitis (ADEM) may relapse and some may ultimately convert to multiple sclerosis (MS); however, no criteria that can predict MS conversion are available to date. Our aim was to describe the clinical and magnetic resonance imaging (MRI) features of patients with an initial ADEM attack ...
Gladstone Douglas E - - 2011
High-dose cyclophosphamide (HDC) is a chemotherapy treatment designed to eradicate autoreative B- and T-cells responsible for lymphocyte-mediated autoimmune illness while sparing the pluripotent blood stem cell of any ill effects. Multiple sclerosis (MS) is the most common inflammatory and demyelinating immune-mediated disorder of the central nervous system in young adults. ...
Rinaldi F - - 2011
Natalizumab has been demonstrated to be highly effective in reducing measures of disease activity, such as clinical relapse rate, and gadolinium (Gd)-enhancing and new or enlarging T2 lesions appearance in patients with relapsing remitting multiple sclerosis (RRMS). Up to date, no data on the effect of natalizumab on cortical pathology ...
Heim K F - - 2011
The efficacy of granulocyte transfusions in patients with HLA alloimmunization is uncertain. A flow cytometric assay using dihydrorhodamine 123 (DHR), a marker for cellular NADPH oxidase activity, was used to monitor the differential survival of transfused oxidase-positive granulocytes in alloimmunized patients with chronic granulomatous disease (CGD). Ten patients with CGD ...
Mostert J P - - 2010
To assess the predictive value of T2 lesions on the rate of progression of disability in multiple sclerosis (MS). We reanalyzed T2 lesion number and load on brain MRI scans, performed before 1997, of 186 MS patients, who were clinically followed. There were 90 patients with progressive MS (35 secondary ...
Kitsos G - - 2011
Background and purpose:  Several previous studies have employed optical coherence tomography (OCT) of the optic disc and 'white-on-white' automated perimetry to evaluate optic neuritis (ON) associated with multiple sclerosis (MS). This study employed OCT, white-on-white automated perimetry as well as 'blue-on-yellow' automated perimetry to evaluate MS patients with or without ...
Sola Patrizia - - 2011
Background: There is increasing evidence on cerebrospinal fluid (CSF) oligoclonal IgM (OCIgM) predicting a more aggressive disease course in relapsing-remitting Multiple Sclerosis (MS), while there is a scarcity of data for primary progressive MS (PPMS). Objective: Our aim was to investigate the presence and possible prognostic value of CSF OCIgM ...
Lo Coco Daniele - - 2010
We aimed to evaluate the frequency and determinants of restless legs syndrome (RLS) in a group of 76 patients with amyotrophic lateral sclerosis (ALS) and 100 control subjects. A diagnosis of RLS was made according to the criteria of the International RLS Study Group, and severity was assessed by the ...
Sacco Rosaria - - 2011
Gait impairment and fatigue are common and disabling problems in multiple sclerosis (MS). Characterisation of abnormal gait in MS patients has been done mainly using observational studies and simple walking tests providing only limited quantitative and no qualitative data, or using intricate and time-consuming assessment procedures. In addition, the correlation ...
Fazio Raffaella - - 2011
Neuromyelitis optica (NMO) is a rare demyelinating disease, affecting selectively the optic nerve and the spinal cord. It was previously considered to be a severe variant of multiple sclerosis (MS) due to the similar pathological features and its resemblance to optico-spinal, or Japanese, MS, typical of Asian populations. The finding ...
Weinstock-Guttman Bianca - - 2011
The associations between vitamin D and MRI measures of brain tissue injury have not been previously investigated in multiple sclerosis (MS). This research evaluates the significance of vitamin D and its active metabolites in brain tissue injury and clinical disability in MS patients. The study population consisted of 193 MS ...
Ahn Suk-Won - - 2010
The motor unit number index (MUNIX) refers to an electrophysiologic technique that measures the approximate number of motor units using the surface electromyographic interference pattern (SIP) recorded during voluntary contraction. This study was done to assess the reproducibility of MUNIX performed on hypothenar muscles in 62 normal controls and 22 ...
Yamout Bassem - - 2010
Extracranial venous stenosis (EVS) has recently been implicated as the primary cause of multiple sclerosis (MS). Objective: The aim of this study was to determine the presence of EVS in MS patients. We performed selective extracranial venography on 42 patients with early MS (EMS): clinically isolated syndrome (CIS) or relapsing-remitting ...
Lode K - - 2010
To examine how coping styles among patients with multiple sclerosis (MS) change over time and how patients' coping styles after 5 years are associated with disability pension. Seventy-six MS patients and 94 healthy controls were included in this study. The patients were examined at baseline and 5 years later. This ...
Kelly S - - 2010
Using atypical symptoms at presentation as red flags to indicate an alternative diagnosis to MS has not been formally assessed. The purpose of this study was to assess the utility of defining the typicality and atypicality of symptoms at presentation in the diagnosis of patients referred as being "query MS". ...
Ingram G - - 2010
Complement is known to play a key role in MS and recent work utilising proteomic analysis identified raised serum levels of C4a in patients compared to controls which decreased following relapse. In order to replicate and validate this finding which has significant implications for the pathogenesis of MS, we have ...
Lin F - - 2011
Many studies have observed atrophy and abnormal diffusion within the CC in MS. However, few studies have addressed whether such abnormalities appear at the earliest stage of MS, especially in CIS. In this study, we aimed to investigate the CC integrity and patterns of CC abnormalities in CIS with diffusion ...
Blanco-Kelly F - - 2011
TNFRSF6B and TNFRSF14 genes were recently associated with Crohn's disease and rheumatoid arthritis. TNFRSF14 is known as herpes virus entry mediator (HVEM), and herpes viruses have been involved in the aetiology of multiple sclerosis (MS). MS patients present human herpes virus 6 (HHV6) in active plaques and increased antibody responses ...
Rigotti D J - - 2011
Neuro-axonal damage is a well known sequelae of MS pathogeneses. Consequently, our aim was to test whether the ∼20% of patients with MS exhibiting a clinically benign disease course also have minimal neural dysfunction as reflected by the global concentration of their MR imaging marker NAA. Q(NAA) was obtained with ...
Schneider Andrea - - 2012
Fragile X-associated tremor/ataxia syndrome (FXTAS) is a late onset neurodegenerative disorder that affects carriers of the fragile X premutation, typically after age 50. Common symptoms include intention tremor, ataxia, neuropathy, autonomic dysfunction, cognitive decline, and dementia. The objectives of this study were to determine if patients with FXTAS have altered ...
Dinacci D - - 2011
Brain derived neurotrophic factor (BDNF) regulates several CNS physiological and pathological processes. To investigate in multiple sclerosis (MS) patients, the relationship between the Val66Met polymorphism of BDNF and clinical markers of disease activity and MRI markers of focal and diffuse brain pathologies. 45 MS patients and 34 healthy controls (HCs) ...
Ben-Amitai D - - 2011
Background  Tuberous sclerosis complex is a multisystem inherited disorder characterized by the development of tumour-like growths in brain, skin and other organs. Although cutaneous vascular anomalies are not considered a common manifestation, we have encountered co-occurrence of port wine stains and tuberous sclerosis. Objective  To assess the prevalence of port ...
Kim Hyun-Jung - - 2011
To monitor increases or decreases in cardiovascular disease (CVD)-related proteins that will be released from the deposits or plaque on the inner wall of blood vessels. Protein profiles of sera from healthy subjects and CVD patients were determined via 2-DE. Differentially expressed spots in CVD patients were identified by ESI-Q-TOF ...
Vaknin-Dembinsky Adi - - 2010
Anti-aquaporin-4 antibodies are believed to have a central pathogenetic role in neuromyelitis optica (NMO). B-cell activating factor (BAFF) is one of the crucial factors that determines the fate and survival of B cells and may play a role in induction of antibody-mediated autoimmunity. To evaluate the blood and cerebrospinal fluid ...
Arababadi Mohammad Kazemi - - 2010
Several lines of evidence exist which suggest that changes in the expression of circulating cytokines are linked to the development or reoccurrence of multiple sclerosis (MS). This study aimed to evaluate the serum levels of relevant cytokines after therapy with IFN-β formulations in MS patients. In this study, blood samples ...
Rietberg Marc B - - 2010
OBJECTIVE: To determine the reproducibility of 24-hour monitoring of motor activity in patients with multiple sclerosis (MS). DESIGN: Test-retest design; 6 research assistants visited the participants twice within 1 week in the home situation. SETTING: General community. PARTICIPANTS: A convenience sample of ambulatory patients (N=43; mean age ± SD, 48.7±7.0y; ...
Sorarù Gianni - - 2010
A new amyotrophic lateral sclerosis (ALS) category named 'UMN-dominant ALS' and defined as 'due predominantly to UMN signs but with minor electromyogram (EMG) denervation or LMN signs on examination' has been proposed. The clinical and laboratory features of 20 patients with UMN-dominant ALS are described here, their disease course is ...
Worthington V - - 2010
Chronic cerebrospinal venous insufficiency (CCSVI) has been suggested to be a possible cause of multiple sclerosis (MS). If the presumed mechanism of venous stasis-related parenchymal iron deposition and neurodegeneration were true, then upregulation of intrathecal iron transport proteins may be expected. This was a cross-sectional (n = 1,408) and longitudinal ...
Mattioli Flavia - - 2011
The objective of the study was to assess the natalizumab effect on the course of cognitive impairment in patients with relapsing-remitting multiple sclerosis (MS). Patients with active relapsing-remitting MS (n = 17) were treated with natalizumab for 1 year. The quasi control group included patients (n = 7) with clinically stable MS. Assessment of disease ...
Mota Patrícia Caetano - - 2011
Prevalence of metabolic syndrome (MS) in obstructive sleep apnea (OSA) patients is high. The effect of autoadjusting positive airway pressure (APAP) on MS remains unclear. This study aimed to determine the prevalence of MS in OSA patients before and 6 months after APAP, and to identify potential determinants of metabolic status ...
Catenoix H - - 2011
The association between epilepsy and multiple sclerosis (MS) is not a coincidence. Our objective was to compare MS patients with or without history of seizures. In a population of 5041 MS patients, we identified 102 (2%) patients with epileptic seizures. In 67 patients (1.3%), epileptic seizure could not be explained ...
Deschamps R - - 2011
Despite similarities, neuromyelitis optica (NMO) can be distinguished from multiple sclerosis (MS) by clinical, radiological and serological findings. This case-control study aimed to determine whether patients with NMO or with MS in an Afro-Caribbean population originating from French West Indies shared the same or different HLA class I and II ...
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