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Nazemian Fatemeh - - 2010
Chronic inflammation in dialysis patients increases the production of cytokines such as TNF-α, IL-1β and IFN- IFN-γ and there is evidence of a significant mortality rate in dialysis patients due to inflammation. Overproduction of inflammatory cytokines can induce complications such as atherosclerosis, malnutrition and anaemia, which are mostly resistant to ...
Khanna Deepshikha - - 2010
To study and compare dermatological manifestations in patients with various stages of chronic kidney disease (CKD) and end stage renal disease (ESRD), undialysed and dialysed, in a developing country. 200 patients were recruited, 50 each in stages 3, 4 and 5 CKD (undialysed) and 50 in stage 5 undergoing maintenance ...
Tomo Tadashi - - 2011
We investigated the effects of online hemodiafiltration (HDF) using acetate-free bicarbonate dialysis (AFD) fluid on bioincompatibility as represented by inflammatory markers in patients undergoing maintenance hemodialysis therapy and compared it with conventional acetate-containing bicarbonate dialysis (ACD) fluid. A total of 24 maintenance hemodialysis patients were registered for cross-over design during ...
Gugliucci Alejandro - - 2010
Studies regarding aspirin metabolism can be important in patients with renal failure who have an increased risk of cardiovascular diseases. We undertook this study to assess the aspirin esterase (AE) status in end-stage renal disease (ESRD) patients. A total of 42 patients on long-term haemodialysis (HD) with a mean dialysis ...
Tabata Taku - - 2010
The role of the accessory pancreatic duct (APD) in pancreatic pathophysiology has been unclear. We previously examined the patency of the APD in 291 control cases who had a normal pancreatogram in the head of the pancreas by dye-injection endoscopic retrograde pancreatography (ERP). APD patency was 43% and was closely ...
Yang Chih-Chao - - 2010
Ultrasonographic evaluation of the kidney size is a useful method for assessment of the progression and, in some cases, the type of nephropathy. Ultrasonography (USG) also plays an important role in the evaluation of both acute and chronic renal failure. To investigate the ultrasonographic appearance of the kidneys in patients ...
Noordzij Marlies - - 2011
Previous studies have shown that simple imaging methods may be useful for detection of vascular calcifications in dialysis patients. Based on annual, plain chest X-rays during follow-up on dialysis, we studied the associations of mineral metabolism with the presence and progression of aortic calcification. In addition, we assessed the impact ...
Coll Blai - - 2010
Cardiovascular disease is the leading cause of mortality in chronic kidney disease (CKD). As matrix metalloproteinases have a major role in atherosclerosis, we hypothesized that alterations in metalloproteinases-8, -10 and their tissue inhibitor-1 can be associated with the severity of atherosclerosis in patients with kidney disease. This was evaluated in ...
Castoldi Giovanna - - 2010
To evaluate oxidative stress in uremia and dialysis and chromogranin A, a stress hormone that could be related to oxidative processes. Plasma oxidative stress biomarkers (-SH, 8-OHdG, and ox-LDL) and chromogranin A were measured in 89 outpatients (21 uremic patients, 17 in peritoneal dialysis, and 51 in haemodialysis), and in ...
Evans M - - 2011
To investigate how the timing of dialysis initiation is associated with mortality. Population-based, prospective, observational cohort study. Clinical laboratories (n = 69) provided information on all patients in Sweden whose serum creatinine level for the first time and exceeded 3.4 mg dL(-1) (men) or 2.8 mg dL(-1) (women) between 20 ...
Johansen Kirsten L - - 2010
Physical inactivity contributes to the frailty and the decline in function that develops over time among patients with end-stage renal disease. We assessed physical activity among 1547 ambulatory patients new to dialysis in the United States Renal Data System Comprehensive Dialysis Study. We used a self-reporting Human Activity Profile that ...
Huang Qiu-Lin - - 2010
The aim of the study was to establish the value of urinary trypsinogen-2 in predicting the severity of acute pancreatitis (AP) and to compare it with the accuracy of the urinary trypsinogen activation peptide (TAP) and the computed tomography severity index (CTSI). The study population consisted of 187 consecutive patients ...
Coaccioli S - - 2010
Oxidative stress is defined as tissue damage caused by an imbalance between the excessive production of the oxidant components and an insufficient defence mechanism. It has been observed, as in patients with chronic kidney failure, that there exists a pro-oxidant state characterised by a higher level of reactive oxygen species ...
Coaccioli S - - 2010
Uraemia is a disease characterised by a significant oxidative stress, and it is a wide agreement that oxidative stress which accompanies uraemia, increases the inflammatory state and promotes the alterations of tiny molecules such as amino acids, proteins, lipids, and carbohydrates. There are numerous records of how ROS are connected ...
Stolic R - - 2010
The results of numerous investigations on the impact of obesity on renal insufficiency conducted in recent years introduce certain dilemmas about their mutual agreement. Some studies suggest that obesity is negatively correlated with the terminal phase of renal failure. On the other hand, other research has shown that reducing the ...
Adabala Madhuri - - 2010
A 48-year-old man, with end-stage renal disease (ESRD) on haemodialysis, presented to the emergency department with sulphonylurea-induced hypoglycaemia. His hypoglycaemia was persistent despite glucose infusion, so he was treated with octreotide. Octreotide administration reversed the hypoglycaemia but also resulted in severe hyperkalaemia. The patient was urgently dialysed, the octreotide was ...
Booth John - - 2011
Intradialytic hypotension remains the commonest complication of routine outpatient haemodialysis treatments. Multifrequency bioimpedance allows assessment of body fluid volumes. Multifrequency bioimpedance can potentially monitor changes in extracellular volume during dialysis and may therefore help to reduce intradialytic hypotension. Hypotension-prone patients have been reported to start dialysis with relatively more fluid ...
Reiche Ines - - 2011
Niaspan® is an extended-release formulation of nicotinic acid with improved tolerability compared with the immediate-release and sustained-release formulations. It is used to treat hypertriglyceridaemia with low high-density lipoprotein levels. This type of dyslipidaemia frequently appears in patients with chronic kidney disease (CKD). Dose recommendations for these patients are not available ...
Souberbielle Jean-Claude - - 2010
The Kidney Disease: Improving Global Outcomes (KDIGO) have recently replaced the K/DOQI guidelines to help nephrologists in diagnosing, treating and monitoring chronic kidney disease mineral and bone disorders (CKD-MBD). Here, we comment on the KDIGO recommendations concerning the interpretation of parathyroid hormone (PTH) concentrations in dialysis patients: "In patients with ...
Parés Albert - - 2010
Albumin dialysis using molecular adsorbent recirculating system (MARS) is a new procedure for treating resistant pruritus from cholestasis, but it is usually published as a case report or a short series. Therefore, we analyzed patients with resistant pruritus treated with MARS from three centers, to assess the changes on pruritus ...
Medrano Guillermo - - 2010
Bioimpedance spectroscopy is a potential candidate for monitoring of body fluids during dialysis. In this article, the suitability of knee-to-knee (KK) as an alternative to wrist-to-ankle (WA) bioimpedance spectroscopy measurements during dialysis is evaluated. Measurements on eight patients (22 dialysis sessions) showed a good correlation between the change in extracellular ...
Iraj Najafi - - 2011
Acute kidney injury (AKI) is a severe and preventable problem of crushed earthquake victims. Early hydration therapy started before fully removing earthquake rubbles has been claimed to play a decisive role in AKI prevention, which saves the necessity of later dialysis. However, the extent, quality, and appropriateness of its know-how ...
Nowicki Micha? - - 2010
BACKGROUND: Pedometers are simple devices which measure spontaneous physical activity. In nonrenal disease populations, pedometers were successfully used to encourage patients to increase their habitual physical activity through self-monitoring of its intensity. Our aim was to investigate how an awareness of using pedometers helps in increasing daily spontaneous physical activity ...
Zabel R - - 2010
BACKGROUND: Haemodialysis patients show signs of chronic inflammation and reduced appetite, which is associated with a worse clinical status and an increased mortality risk. Fish oil has anti-inflammatory properties and may be useful as a therapeutic treatment. There is limited evidence to indicate the feasibility and efficacy of this intervention ...
Sozeri Betul - - 2010
Cardiovascular disease is a leading cause of long-term morbidity and mortality among children with chronic kidney disease (CKD). At which stage of CKD these appear in children is unknown. This study aimed to determine the prevalence of cardiovascular disease in pediatric CKD patients and to explore the relationship of these ...
Wesseling-Perry Katherine - - 2010
Factors contributing to PTH resistance in dialysis patients remain elusive. The study assessed the skeletal and biochemical response to 46 h of PTH(1-34) infusion in dialysis patients. The study was a prospective, controlled assessment of response to PTH(1-34). The study was performed at the University of California, Los Angeles, General ...
Chan Wing Lam Winnie - - 2010
Lanthanum carbonate (LC) is a noncalcium-containing phosphate binder of proven utility in treating hyperphosphatemia in dialysis patients, and displays a good tolerability profile. This study addressed whether this tolerability profile could result in improved phosphate control in patients intolerant of other phosphate binders, and who remain hyperphosphatemic despite intensive dietary ...
Hsu Ching-Wei - - 2010
AIM: Chronic inflammation, which is common in dialysis patients, often causes malnutrition and even protein-energy wasting. However, the association of high-calcium dialysate with malnutrition and/or inflammation in non-diabetic maintenance haemodialysis patients remains unclear. This study investigated the possible adverse effects of high-calcium dialysate and mortality in this population. METHODS: A ...
Nasrallah Mohamed M - - 2010
BACKGROUND: Vascular calcification has detrimental consequences on chronic kidney disease (CKD) patients, yet its pathogenesis is not fully understood. Fibroblast growth factor-23 (FGF-23) is involved in the regulation of mineral metabolism which may in turn affect vascular calcification. Data on the relationship between FGF-23 and peripheral vascular calcification, using conventional ...
Lassalle Mathilde - - 2010
Starting patients on dialysis early has been increasing in incidence in several countries. However, some studies have questioned its utility, finding a counter-intuitive effect of increased mortality when dialysis was started at a higher estimated glomerular filtration rate (eGFR). To examine this issue in more detail we measured mortality hazard ...
Ashizawa Tatsuto - - 2010
We investigated changes in drug disposition and toxicities with CPT-11 in 15 dialysis patients with gastrointestinal cancers to clarify whether CPT-11 could be administered safely in such patients. For comparison, the same parameters were also investigated in 10 cancer patients not undergoing dialysis. Items investigated included (1) plasma concentrations of ...
Bäumer Amelie - - 2010
To identify dialysis patients with low fetuin-A levels, a sensitive immunoluminometric assay (ILMA) was developed. For the two-site ILMA, one monoclonal antibody was coated to polystyrene beads and one polyclonal antibody was labelled with acridinium ester. The lower detection threshold was 0.013 g/L, with the normal range 0.20-0.87 g/L (arithmetic ...
Walkowiak Jaroslaw - - 2010
High prevalence of elevated serum pancreatic enzymes in children with cholestasis with normal fecal elastase-1 concentrations has been documented. However, this state is related predominantly to biliary atresia. Therefore, we aimed to assess pancreatic damage by measuring serum pancreatic enzymes in patients with progressive familial intrahepatic cholestasis type 2 (PFIC ...
Gallucci F - - 2010
This study was addressed to assess the clinical characteristics of patients presenting with chronic hyperamylasemia unrelated to pancreatic diseases (CHUPD). Almost all patients presenting with chronic hyperamylasemia undergo expensive, long, difficult, and often unnecessarily repeated diagnostic procedures. This is in conjunction with the poor knowledge of the fact that besides ...
do Nascimento Ginivaldo Victor Ribeiro - - 2010
The indications for dialysis in patients with acute kidney injury (AKI), as well as the dose and timing of initiation, remain uncertain. Recent data have suggested that early initiation of renal replacement therapy (RRT) may be associated with decreased mortality but not with the recovery of kidney function. A blood ...
Molina Núñez M - - 2010
The haemodialysis dose is a good marker of dialysis adequacy, and we usually monitor it with Kt/V measure. The dialysis dose monitored with Kt allows a better discrimination, detecting a percentage of the patients that perhaps do not get an adequate dose for their gender or body surface area after ...
Malekmakan Leila - - 2010
INTRODUCTION: We conducted this study to measure hemodialysis adequacy and determine to what extent some Kidney Disease Outcomes Quality Initiative (KDOQI) goals are achieved in our patients. MATERIALS AND METHODS: In a cross-sectional study in Fars province, Iran, we assessed 632 patients on hemodialysis in 15 dialysis centers. The Kt/V ...
Baskin Esra - - 2010
This article reviews our experience with 111 pediatric patients following open-heart surgery over 1-year period. Peritoneal dialysis was required in 34 of 111 children (30.6%). We randomly selected 33 patients who did not require peritoneal dialysis as control group. The indications of dialysis were oligoanuria and/or elevated serum creatinine level ...
Musso C G - - 2010
Chronic dialysis is a valid therapeutic option in very elderly ESRD patients, even though the decision to dialyze or not has little impact on survival. Additionally, very old patients usually do not agree with starting chronic dialysis. Even though, activated charcoal is a cheap treatment for working as adsorbent for ...
Campostrini Natascia - - 2010
The hepatic iron regulator hormone hepcidin consists, in its mature form, of 25 amino acids, but two other isoforms, hepcidin-20 and hepcidin-22, have been reported, whose biological meaning remains poorly understood. We evaluated hepcidin isoforms in sera from 57 control and 54 chronic haemodialysis patients using a quantitative proteomic approach ...
Nieto J - - 2010
Patients under chronic dialysis treatment suffer from atherosclerotic disease and anemia more frequently than the normal population. This, together with the frequent hypotension, put these patients at increased risk for anterior ischemic optic neuropathy (AION), which may be bilateral and blinding. We present two cases of patients under chronic dialysis ...
Ramasubbu Kumudha - - 2010
Pulmonary hypertension (PH), a disease which carries substantial morbidity and mortality, has been reported to occur in 25%-45% of dialysis patients. No prospective evaluation of the prevalence or clinical significance of PH in chronic dialysis patients in the United States (US) has been undertaken. Echocardiograms were performed prospectively in chronic ...
López-Gómez J M - - 2010
Darbepoetin alpha (DA) administered every-other-week (Q2W) is efficacious and safe for the treatment of anaemia in patients undergoing dialysis. There are no data available regarding the evolution of erythropoietic resistance index (ERI) after conversion from weekly (QW) to Q2W administration of DA in clinical practice. Multicenter, observational, retrospective, 16-weeks study, ...
Caussé E E CHU RANGUEIL, Toulouse University, France. - - 2010
To investigate the possible relationship between homocysteine and allantoin levels in hemodialyzed patients, serum levels of thiols and purine compounds were analyzed before and after dialysis sessions. 16 clinically stable non-diabetic patients hemodialyzed on polysulfone membranes were compared with 36 control subjects. Serum samples were collected before and after hemodialysis ...
Talar-Wojnarowska Renata R Department of Digestive Tract Diseases, Medical University of Lodz, Katowice, Poland. - - 2010
Neopterin and tissue polypeptide-specific antigen (TPS) have been suggested to be useful in differential diagnosis between pancreatic adenocarcinoma (PA) and chronic pancreatitis (CP). The aim of our study was to compare the clinical usefulness of CA19-9, neopterin and TPS serum levels in patients with PA and CP. The study included ...
Eloot Sunny - - 2010
BACKGROUND: Absorption of large quantities of iodine, as induced by the use of topical antimicrobial povidone-iodine in burn-injured patients, may cause metabolic and electrolyte abnormalities as well as renal failure. To diminish iodine levels, haemodialysis was previously reported to be a suitable therapy. We therefore studied the kinetics of iodine ...
Shimada Takashi T Endocrine Unit, Thier 10, 50 Blossum Street, Massachusetts General Hospital, Boston, Massachusetts 02114, - - 2010
Fibroblast growth factor 23 (FGF23) regulates phosphorus homeostasis and vitamin D metabolism. Circulating FGF23 levels are elevated in inherited and acquired hypophosphatemic disorders that can cause rickets or osteomalacia. Particularly increased concentrations of FGF23 are observed in patients with chronic kidney disease (CKD), in which increased FGF23 is associated with ...
Anees Muhammad - - 2009
OBJECTIVE: To determine the survival of patients undergoing chronic maintenance hemodialysis by determining the relative risk (RR) of anemia and hypoalbuminemia at initiation of dialysis on survival. STUDY DESIGN: Cohort study. PLACE AND DURATION OF STUDY: Hemodialysis Unit of Shalamar Hospital, Lahore, from June 2003 to October 2006. METHODOLOGY: This ...
Nakai Shigeru - - 2009
A nationwide statistical survey of 4098 dialysis facilities was conducted at the end of 2007, and 4052 facilities (98.88%) participated. The number of patients undergoing dialysis at the end of 2007 was determined to be 275 242, an increase of 10 769 patients (4.1%) compared with that at the end ...
Spiegel David M - - 2010
BACKGROUND: Erythropoiesis-stimulating agents (ESAs) have had a positive effect on anemia treatment in dialysis patients. However, several events in recent years, including new clinical study results, ESA product label revisions, and coverage and reimbursement policy changes, have had an impact on ESA dosing patterns and consequently on hemoglobin (Hb) distribution ...
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