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Burgess Richard E - - 2011
Multimodal neuroimaging is assuming an increasingly important role in the initial evaluation and management of acute stroke patients in parallel with the expansion of therapeutic options. Multimodal MRI can identify the type of stroke (ischemia or hemorrhage), severity and location of the lesion, the patency of the intracranial vessels, the ...
Burger Charles D - - 2011
To investigate the correlation between body mass index (BMI) and pulmonary artery systolic pressure in a large population of patients with pulmonary arterial hypertension (PAH). The BMI of patients with group 1 PAH enrolled in the Registry to Evaluate Early and Long-term PAH Disease Management (REVEAL) was compared with that ...
Vasileiou A-M - - 2011
Oedema is a common finding in obesity and its cause is not always clear. Possible causes include impairment of cardiac, respiratory and/or renal function, chronic venous insufficiency and lymphatic problems. Lymphoscintigraphy is the best method to detect structural lymphatic abnormalities that can cause lymphoedema. We reviewed 49 female subjects with ...
Kuruvilla Abraham - - 2011
Up to 15-25% of patients with ischemic stroke wake up with their deficits. Because of the uncertainty about the time of onset, these patients are generally not offered thrombolytic therapy. Some of these wake-up stroke patients may be eligible for acute endovascular stroke therapy based on hyperacute CT or MR ...
Zimmermann Esther - - 2011
Non-alcoholic fatty liver disease (NAFLD) is a major hepatic consequence of obesity. It has been suggested that the high sensitivity C-reactive protein (hs-CRP) is an obesity-independent surrogate marker of severity of NAFLD, especially development of non-alcoholic steato-hepatitis (NASH), but this remains controversial. We aimed to investigate whether associations between various ...
Cohen Gerald - - 2011
Dysfunction of polymorphonuclear leucocytes (PMNLs) in end-stage renal disease (ESRD) patients contributes to a diminished immune defence. The serum levels of leptin are elevated in patients with ESRD. We analysed in vitro effects of leptin on PMNLs from healthy subjects (HS; n = 12) and haemodialysis (HD) patients (n = ...
Feuillan Penelope P - - 2011
Bardet-Biedl syndrome (BBS) is a genetically heterogeneous disorder of the primary cilium associated with obesity. In BBS mouse models, ciliary dysfunction leads to impaired leptin signaling and hyperleptinemia before obesity onset. To study the pathophysiology of obesity in BBS, we compared patients with BBS and body mass index Z-score (BMI-Z)-matched ...
Koskinen Anna - - 2011
In the present study, we investigated the role of adipocytokine leptin in the pathogenesis of osteoarthritis (OA) by measuring its effects on matrix metalloproteinase (MMP) production in human OA cartilage. In addition, the correlations between leptin and MMP concentrations in synovial fluid from OA patients were studied. Cartilage tissue obtained ...
Schiavon Leonardo L - - 2011
The role of apoptosis in treatment-induced HCV clearance is controversial. We sought to assess the kinetics of serum apoptosis-related cytokines during pegylated interferon-α2a or -α2b plus weight-based ribavirin therapy for genotype 1 chronic HCV infection. Serum levels of soluble Fas (sFas), soluble Fas ligand (sFasL) and soluble tumour necrosis factor ...
Moriyama Yukie - - 2011
The risk of cardiovascular disease is substantially high in hemodialysis patients. The risk factors for cardiovascular disease in dialysis patients include age, malnutrition, duration of dialysis, diabetes mellitus and hyperphosphatemia. However, it is not clear whether cardiovascular disease is associated with abdominal obesity in dialysis patients. The aim of the ...
Binder R K - - 2011
The burden of abdominal obesity (AO) and its association with other cardiovascular risk factors is not known in coronary artery disease (CAD) patients attending cardiac rehabilitation (CR). The aim of this study was, therefore, to investigate the prevalence of AO and differences in cardiovascular risk factors between AO and non-AO ...
Díez Juan José - - 2011
We aimed to evaluate the relationship between serum leptin and the leptin/body mass index (BMI) ratio with prevalent cardiovascular disease (CVD), and their influence on all-cause and CVD-related mortality in patients on hemodialysis (HD). 118 stable HD patients (50 women, median [interquartile range] age, 65.1 [54.7-72.2] years) were studied. All ...
Koh S-H - - 2011
in this prospective study, we evaluated mutual relationships amongst microbleeds, matrix metalloproteinase-9 (MMP-9) and neurological deterioration in patients with their first acute lacunar stroke. based on diffusion-weighted image findings, we recruited 206 patients with their first acute lacunar stroke. Those without a MRI scan were excluded. Small (a maximum lesion ...
Vayá A - - 2011
Background: The pathogenic role of hyperhomocysteinemia in cryptogenic stroke is not well established. We aimed to determine homocysteine levels in patients with cryptogenic stroke considering the possible variables that may act as confounders and analyze the influence of obesity on this association. Patients and methods: We conducted a case-control study ...
Al-Mutairi Nawaf - - 2011
Objective: The aim of the present study was to determine the spectrum of skin diseases seen among adult obese patients referred to Farwaniya Hospital. Materials and Methods: A total of 437 overweight/obese subjects (200 men and 237 women) aged 18-74 years were enrolled in the study, which was conducted from ...
Janssen A W M - - 2011
To analyze risk factors for ischemic stroke and transient ischemic attack (TIA) in young adults under the age of 50. To make recommendations for additional research and practical consequences. From 97 patients with ischemic stroke or TIA under the age of 50, classical cardiovascular risk factors, coagulation disorders, history of ...
Pecori Giraldi Francesca - - 2011
Desmopressin is a known haemostatic agent and is also being used, albeit at lower doses, during the diagnostic work-up of Cushing's syndrome, a condition characterized by excess cortisol concentrations and frequent thromboembolic events. No study has yet evaluated whether administration of desmopressin for diagnostic purposes induces significant, adverse changes in ...
Hung Jen-Wen JW Department of Rehabilitation, Chang Gung Memorial Hospital-Kaohsiung Medical Center, Chang Gung University College of Medicine, - - 2011
The objectives of this study are to investigate the long-term effect of anterior ankle-foot orthosis on the functional walking ability of chronic stroke patients and their subjective perception and to identify the type of chronic stroke patients who are better responders to the wearing of anterior ankle-foot orthosis. This is ...
Karcz W K - - 2011
Background. Nonalcoholic fatty liver disease is present in up to 85% of adipose patients and may proceed to nonalcoholic steatohepatitis (NASH). With insulin resistance and obesity being the main risk factors for NASH, the effect of isolated sleeve gastrectomy (ISG) on these parameters was examined. Methods. 236 patients underwent ISG ...
Barceló A - - 2011
Obesity and metabolic syndrome (MS) occur frequently in patients with obstructive sleep apnoea syndrome (OSAS). We hypothesised that circulating free fatty acids (FFAs) are elevated in OSAS patients independently of obesity. This elevation may contribute to the development of MS in these patients. We studied 119 OSAS patients and 119 ...
Chou Yii-Her - - 2010
The prevalence and incidence of urinary stone disease have been reported to be associated with body weight and body mass index (BMI). The aim of the study was to determine the difference in stone components among different BMI groups in patients with urolithiasis. Between Dec 2005 and Jan 2008, 907 ...
Frauscher Birgit - - 2011
Friedreich ataxia (FA) is the most common type of hereditary ataxia. Frataxin deficiency due to a GAA expansion in the first intron of chromosome 9 results in intramitochondrial iron accumulation. On the basis of the patients' complaints about sleep disturbance and pathophysiological considerations, we systematically assessed sleep history and polysomnography ...
Frauscher Birgit - - 2010
Friedreich ataxia (FA) is the most common type of hereditary ataxia. Frataxin deficiency due to a GAA expansion in the first intron of chromosome 9 results in intramitochondrial iron accumulation. On the basis of the patients' complaints about sleep disturbance and pathophysiological considerations, we systematically assessed sleep history and polysomnography ...
Benson Lacey J - - 2011
Obesity is becoming an increasingly prevalent problem among American children. Screening for obesity associated comorbid conditions has been shown to be inconsistent. The current study was undertaken to explore patterns of ordering screening tests among obese pediatric patients. We analyzed electronic medical records (EMR) from 69,901 patients ages 2-18 years ...
Vemmos Konstantinos - - 2011
limited data exist concerning obesity and survival in patients after acute stroke. The objective of this study was to investigate the association between obesity and survival in patients with acute first-ever stroke. patients were prospectively investigated based on a standard diagnostic protocol over a period of 16 years. Evaluation was ...
Galougahi K K - - 2010
Background:  Assessment for source of stroke is a common indication for transoesophageal echocardiography (TOE). Although an abnormality is frequently found, it remains uncertain how frequently the findings alter patient management. Also, the role of transthoracic echocardiography (TTE) prior to or instead of TOE is not well defined. We sought to ...
Gur Alexander Y - - 2010
Cerebral hemodynamic features of patients with post-stroke dementia (PSD) are still obscure. We compared cerebral vasomotor reactivity (VMR) assessed in the acute phase of ischemic stroke (IS) in patients with and without PSD. VMR was also assessed and compared in demented and non-demented patients in the late phase of IS. ...
Jang Sung Ho - - 2010
We reviewed the literature on walking recovery of stroke patients as it relates to the following subjects:epidemiology of walking dysfunction, recovery course of walking, and recovery mechanism of walking (neural control of normal walking, the evaluation methods for leg motor function, and motor recovery mechanism of leg).The recovery of walking ...
Wu Ming-Ju - - 2011
The aim of this study was to investigate whether physical evaluations could be used for predicting the presence and severity of obstructive sleep apnea (OSA) in non-obese snoring patients. This is a retrospective study, and a total of 244 non-obese (body mass index, BMI, <27 kg/m(2)) snoring patients (178 men and ...
Ishikawa Yuichi - - 2010
Cerebral aneurysms (CA) are incidentally detected by magnetic resonance angiography (MRA) in acute stroke patients or asymptomatic volunteers. We investigated whether incidental CA influences stroke subtypes and clinical outcome of patients with acute brain infarction (BI) and hemorrhage (BH). Moreover, frequency and neuroradiological profile of incidental CA were compared between ...
Rost N S - - 2010
White matter hyperintensity (WMH) may be a marker of an underlying cerebral microangiopathy. Therefore, we hypothesized that WMH would be most severe in patients with lacunar stroke and intracerebral hemorrhage (ICH), 2 types of stroke in which cerebral small vessel (SV) changes are pathophysiologically relevant. We determined WMH volume (WMHV) ...
De Castro Stefano - - 2010
We evaluated the feasibility and clinical utility of transesophageal echocardiography (TEE) in the early management of ischemic stroke. TEE was performed in consecutive patients with acute cerebral ischemia within 48 hours of symptoms onset. The data were analyzed by age (<55 vs ≥55 years), and the baseline stroke etiology was ...
Domingues-Montanari S - - 2010
The angiotensin-converting enzyme 1 (ACE1) gene has been extensively studied in stroke, yet generating conflicting results. The goal of our study was thus to clarify the influence of the ACE1 on the risk of suffering an ischaemic stroke (IS). We genotyped the rs4341 (in linkage disequilibrium with the I/D polymorphism) ...
Schulz U - - 2010
Introduction The explanation for the prognostic value of the ABCD2-score remains uncertain. If it genuinely measures cerebral susceptibility to ischaemia, it should correlate with other markers of susceptibility, such as leukoaraiosis (LA). We studied the association of the ABCD2-score with the severity of LA in a large cohort of patients ...
Roerdink Melvyn - - 2011
. In hemiplegic gait, step length typically differs in magnitude between paretic and nonparetic sides. However, the direction of step-length asymmetry varies across stroke patients. . The study sought to understand directional variations in step-length asymmetry in terms of asymmetries in forward foot placement relative to the trunk and trunk ...
Liu Y - - 2010
To evaluate apparent diffusion coefficient (ADC) in cerebellar subregions in patients with stroke. The total counts and ADCs were bilaterally measured on cerebellar white matter, gray matters of medial (G1), intermediate (G2), and lateral zones (G3) on SPECT and ADC maps from 20 patients with supratentorial ischemic stroke within the ...
Bouffioulx Edouard E Unité de Réadaptation et de Médecine Physique, Université Catholique de Louvain, Brussels, Belgium. - - 2010
To investigate clinical changes among the acute, post-acute and chronic phases in stroke patients' satisfaction with activities and participation. The SATIS-Stroke questionnaire's sensitivity to change was investigated with a sample of 45 stroke patients. The SATIS-Stroke questionnaire was used to collect data from the 45 patients (mean age 69 years, ...
Iguchi Yasuyuki - - 2011
Our aim was to confirm the utility of paramedics using the Kurashiki Prehospital Stroke Scale (KPSS), with a maximum score of 13, for patients who may be eligible for administration of intravenous tissue plasminogen activator (IV t-PA). The subjects comprised acute stroke and transient ischemic attack (TIA) patients transferred to ...
Carod-Artal Francisco Javier - - 2011
The knowledge about the natural history of stroke in Chagas disease is incomplete. Vascular risk factors and stroke subtypes of asymptomatic Trypanosoma cruzi-infected patients with no clinical evidence of heart failure were assessed. They were compared with chronic chagasic cardiomyopathy patients who suffered a stroke and with a control group ...
Tsivgoulis Georgios - - 2011
Background and purpose A recent retrospective study using an online list service established by the American Academy of Neurology has suggested that ischaemic cerebrovascular events may occur in patients who undergo 'bubble studies' (BS) with either transcranial Doppler (TCD) or transoesophageal echocardiography (TOE). The safety of TCD-BS for right to ...
Mendioroz M - - 2011
Osteopontin (OPN) is a multifunctional protein which has shown neuroprotective properties in animal models of cerebral ischemia. Nevertheless, its role in acute human stroke has not yet been established. Therefore, we aimed to determine human serum OPN level during acute ischemic stroke and its relationship with patient outcome. We measured ...
Chan Wesley - - 2010
Patients with TIA and minor stroke are at high risk for recurrent stroke. Obstructive sleep apnea (OSA) may increase this risk. The objectives of our study were to determine the prevalence and severity of OSA and its clinical presentation in this population. Patients who presented with TIA and minor stroke ...
Alvarez-Perez F J - - 2011
ABSTRACT Background: Lower level of albumin was related to worse prognosis of stroke and clinical trials showed that albumin therapy reduced mortality. However, stroke is heterogeneous and differences in the baseline concentration of albumin among subtypes of stroke were not assessed. The aim was to assess albumin level in patients ...
Seitz Rüdiger J - - 2011
The factors determining recovery from hemiparetic stroke are manifold. We studied spontaneous arm movement activity in the acute phase after stroke as a predictor of recovery. Included in this prospective study were 25 patients (63 ± 10 years; 9 women, 16 men) with acute middle cerebral artery stroke and 7 control patients without ...
Coelho Fernando Morgadinho Santos - - 2010
The association between obstructive sleep apnea and stroke is well established. Less is known about the relationship between stroke and periodic limb movements of sleep (PLMS). This study sought to assess the frequency of PLMS in patients with a history of stroke. We reviewed the medical and polysomnographic records of ...
Alhadramy Osama - - 2010
BACKGROUND AND PURPOSE: Our aims were to quantify the yield of Holter monitor for detection of paroxysmal atrial fibrillation (PAF) in patients with stroke and TIA, and to determine potential predictors of PAF to allow more focused testing. METHODS: We reviewed records of 1128 consecutive patients attending a university stroke ...
Hoshino Haruhiko - - 2012
To evaluate the independent effect of moderate renal dysfunction on stroke severity and to disclose the clinical features of stroke patients with moderate renal dysfunction. We studied consecutive stroke patients presenting within 48 hours of onset. The National Institutes of Health Stroke Scale (NIHSS) score at the time of presentation ...
Dankbaar J W - - 2011
Damage to the blood brain barrier (BBB) may lead to haemorrhagic transformation after ischaemic stroke. The purpose of this study was to evaluate the effect of patient characteristics and stroke severity on admission BBB permeability (BBBP) values measured with perfusion-CT (PCT) in acute ischaemic stroke patients. We retrospectively identified 65 ...
Michel Patrik - - 2010
BACKGROUND AND PURPOSE: Stroke registries are valuable tools for obtaining information about stroke epidemiology and management. The Acute STroke Registry and Analysis of Lausanne (ASTRAL) prospectively collects epidemiological, clinical, laboratory and multimodal brain imaging data of acute ischemic stroke patients in the Centre Hospitalier Universitaire Vaudois (CHUV). Here, we provide ...
Gupta Nishant - - 2010
The purpose of this study was to determine the value of transesophageal echocardiography (TEE) in determining the presence of cardiac manifestations that required anticoagulation in patients presenting with acute stroke. Of 626 consecutive stroke patients who underwent TEE, 188 patients with no obvious etiology for stroke were subcategorized according to ...
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