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de Ferranti Sarah D SD 1Department of Cardiology, Boston Children's Hospital, Boston, MA, - - 2014
Background. Omega-3 fatty acids supplements lower triglyceride (TG) levels in adults; little pediatric information is available. We evaluated their effect in hypertriglyceridemic adolescents. Methods. Twenty-five patients aged 10 to 19 years with TG levels 150 to 1000 mg/dL were randomized to 6 months double-blind trial of Lovaza (~3360 mg docosahexaenoic ...
Hua Wen Jin WJ Department of Pharmacy, The First Affiliated Hospital of Nanchang University, Nanchang, China, - - 2014
Chinese herbal medicines such as hawthorn, salvia, etc., are frequently combined with statins so as to treat cardiovascular diseases more effectively. Chinese herbal medicines contain many kinds of active components, which may have drug-drug interactions with statins. This study aims to explore the effect and mechanism by which ursolic acid ...
Gebauer S K SK USDA, Agricultural Research Service, Beltsville Human Nutrition Research Center, Beltsville, MD, - - 2014
The effects of stearic acid (STA) on cardiovascular disease risk beyond lipid and lipoprotein risk factors, including hemostasis, are unclear, particularly when compared with unsaturated fatty acids. The aim of the present study is to compare the effects of STA with those of oleic acid (OL) on markers of hemostasis. ...
Lee Na-Ri NR College of Natural Resources and Life Science, Life and Industry Convergence Institute, Pusan National University, Miryang, 627-706, Republic of - - 2014
The objectives of this study was to improve poly-γ-glutamic acid (γ-PGA) production by Bacillus subtilis D7 isolated from a Korean traditional fermented food and to assess its antioxidant activity for applications in the cosmetics and pharmaceutical industries. Strain D7 produced γ-PGA in the absence of L-glutamic acid, indicating L-glutamic acid-independent ...
Xu Lisheng L Department of Chemistry and Life Science, Suzhou University, Suzhou, 234000, People's Republic of China, - - 2014
A new method for the synthesis of γ-glutamylmethylamide is presented. Glutamic acid γ-methyl ester was used as substrate for γ-glutamylmethylamide synthesis catalyzed by Escherichia coli with γ-glutamyltranspeptidase activity. Reaction conditions were optimized by using 300 mM glutamic acid γ-methyl ester and 3,000 mM methylamine at pH 10 and 40 °C. Bioconversion rate of ...
Shea Beverley B From the Bruyère Research Institute (BRI); Centre for Global Health, Institute of Population Health, University of Ottawa, Ottawa, ON, Canada; Epidemiological Research Center, National Academy of Medicine, Buenos Aires, Argentina; Rheumatology Division, Department of Medicine, Siriraj Hospital, Mahidol University, Bangkok, Thailand; Cochrane Musculoskeletal Group, Ottawa; Institute for Work and Health, Toronto; Department of Epidemiology and Community Medicine, and the Department of Medicine, Faculty of Medicine, University of Ottawa; Ottawa Hospital Research Institute, Clinical Epidemiology Program; Institute of Population Health and Department of Epidemiology and Community Medicine, University of Ottawa, Ottawa, ON, - - 2014
To perform a systematic review of the benefits and harms of folic acid and folinic acid in reducing the mucosal, gastrointestinal, hepatic, and hematologic side effects of methotrexate (MTX); and to assess whether folic or folinic acid supplementation has any effect on MTX benefit. We searched the Cochrane Library, MEDLINE, ...
Adams Mark K MK University of Alabama - Birmingham, United - - 2014
The retinoic acid inducible Dehydrogenase Reductase 3 (DHRS3) is thought to function as a retinaldehyde reductase that controls the levels of all trans retinaldehyde, the immediate precursor for bioactive all trans retinoic acid. However, the weak catalytic activity of DHRS3 and the lack of changes in retinaldehyde conversion to retinol ...
Guo Wei W Tianjin Key Laboratory for Industrial BioSystem and Bioprocessing Engineering, Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, 32 Xiqidao, Airport Economic Park, Tianjin, 300308, - - 2014
Lactobacillus brevis is a promising lactic acid producing strain that simultaneously utilizes glucose and xylose from lignocellulosic hydrolysate without carbon catabolic repression and inhibition. The production of by-products acetic acid and ethanol has been the major drawback of this strain. Two genes, pfkA (fructose-6-phosphate kinase [PFK]) and fbaA (fructose-1,6-biphosphate aldolase ...
Chang Lan L Zhejiang Provincial Key Laboratory of Pathophysiology, Medical School, Ningbo University, Ningbo, 315211, China, - - 2014
Soluble amyloid-β protein (Aβ) oligomers have been recognized to be early and key intermediates in Alzheimer's disease-related synaptic dysfunction. In this study, using in vitro electrophysiology, we investigated interactions of the acidic oligosaccharide sugar chain (AOSC), a marine-derived acidic oligosaccharide, with oligomeric Aβ. We found that the inhibition of long-term ...
Brunke Sascha S Department of Microbial Pathogenicity Mechanisms, Hans Knoell Institute, Jena, - - 2014
The ability to acquire nutrients during infections is an important attribute in microbial pathogenesis. Amino acids are a valuable source of nitrogen if they can be degraded by the infecting organism. In this work, we analyzed histidine utilization in the fungal pathogen of humans, Candida glabrata. Hemiascomycete fungi, like C. ...
Reed Harris Allison Early - - 2014
Pyruvic acid in the atmosphere is found in both the gas and aqueous phase and its behavior gives insight into other alpha-keto acids. Photolysis is a significant degradation pathway for this molecule in the environment, and in aqueous solution the major photoproducts are higher molecular weight compounds which may contribute ...
McMaster Claire - - 2014
Simple solid-phase synthesis of 4,4-dioxo-1,4-dihydro-46-thia-1,3a,9-triaza-cyclopenta[b]naphthalen-2-ones is described, with Fmoc--amino acids and 2-nitrobenzenesulfonylchlorides (2-NosCls) being the key building blocks. Fmoc--amino acids were immobilized on Wang resin and transformed to the corresponding 2-nitrobenzenesulfonamides in two steps. After reduction of the nitro group, Fmoc-thioureas were synthesized followed by cyclization of the 1,2,4-benzothiadiazine-1,1-dioxide scaffold ...
Wang Bo B Department of Internal Medicine, South Branch of Yantaishan Hospital, Yantai 264025, Shandong Province, China. Electronic address: - - 2014
Cilostazol is a drug licensed for the treatment of intermittent claudication. Its main action is to elevate intracellular levels of cyclic monophosphate (cAMP) by inhibiting the activity of type III phosphodiesterase, a cAMP-degrading enzyme. The effects of cilostazol on fatty acid oxidation (FAO) are as yet unknown. In this study, ...
Numnuam Apon A Trace Analysis and Biosensor Research Center, Prince of Songkla University, Hat Yai, Songkhla, 90112, Thailand, - - 2014
A novel amperometric uric acid biosensor was fabricated by immobilizing uricase on an electrospun nanocomposite of chitosan-carbon nanotubes nanofiber (Chi-CNTsNF) covering an electrodeposited layer of silver nanoparticles (AgNPs) on a gold electrode (uricase/Chi-CNTsNF/AgNPs/Au). The uric acid response was determined at an optimum applied potential of -0.35 V vs Ag/AgCl in a ...
de Castro Antonio A a Food Biotechnology Department , Instituto de la Grasa (C.S.I.C.) , Seville , - - 2014
The effects of different packing conditions and storage times on the stability of monosodium glutamate (MSG) added to two different fermented vegetables (Spanish-type green table olives and pickled cucumbers) were studied. Factors such as packaging material (glass bottle vs. plastic pouch), heat treatment (pasteurization vs. non-pasteurization), and the presence or ...
Chen Mingxun M Dr Zhejiang - - 2014
ABSTRACT Fatty acids (FAs) and FA-derived complex lipids have important functions in plant growth and vegetative development. They are a class of prominent metabolites stored in mature seeds. The factors and regulatory networks that control FA accumulation in plant seeds remain largely unknown. The function of TRANSPARENT TESTA 8 (TT8) ...
Deng Haiqiang H Laboratoire d'Electrochimie Physique et Analytique, Ecole Polytechnique Fédérale de Lausanne (EPFL), Station 6, CH-1015 Lausanne, Switzerland. - - 2014
Lithium cations are shown to have a significant role in catalyzing oxygen and proton reduction along with SN1 reactions in biphasic systems. We propose that this catalytic effect is due to the surprising acidity of the hydrated cations; interactions between the cation and its surrounding solvation shell will make the ...
Strandberg Ursula U Department of Biology, University of Eastern Finland, PO Box 111, 80101, Joensuu, Finland, - - 2014
The aim of this study was to assess metabolic pathways for arachidonic acid (20:4n-6) biosynthesis in Daphnia magna. Neonates of D. magna were maintained on [(13)C] enriched Scenedesmus obliquus and supplemented with liposomes that contained separate treatments of unlabeled docosapentaenoic acid (22:5n-6), 20:4n-6, linoleic acid (18:2n-6) or oleic acid (18:1n-9). ...
Kinzurik Matias I MI Department of Chemistry and ‡Department of Biochemistry and Cell Biology, Rice University , Houston, Texas 77005, United - - 2014
Combining bioengineering with chemical synthesis has enabled an efficient method for producing Δ7-dafachronic acid, a steroidal hormone associated with nematode germline longevity. Saccharomyces cerevisiae was engineered to produce 7,24-cholestadienol, a convenient starting material for a four-step synthesis of Δ7-dafachronic acid.
Stremmel Wolfgang W Department of Gastroenterology, University Hospital Heidelberg, Heidelberg, - - 2014
Excess hepatic fat accumulation leads to nonalcoholic steatohepatitis (NASH), a serious threat to health for which no effective treatment is available. However, the mechanism responsible for fatty acid uptake by hepatocytes remains unclear. Using the human hepatocyte-derived tumor cell line HepG2, we found that fatty acid influx is mediated by ...
Matsui Takahide T Graduate School of Life Sciences, Tohoku University, - - 2014
Small GTPase Rab12 regulates mTORC1 (mammalian target of rapamycin complex 1) activity and autophagy through controlling PAT4 (proton/amino acid transporter 4) trafficking from recycling endosomes to lysosomes, where PAT4 is degraded. However, the precise regulatory mechanism of the Rab12-mediated membrane trafficking pathway remained to be determined, because a physiological Rab12-GEF ...
Gelabert-Baldrich Mariona M *Departament de Biologia Cellular, Immunologia i Neurociències, Facultat de Medicina, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), and †Unitat de Microscopia Òptica Avançada, Facultat de Medicina, Centres Científics i Tecnològics, Universitat de Barcelona, Barcelona, - - 2014
The endocytic compartment is emerging as a functional platform for controlling important cellular processes. We have found that ∼10 to 15% of total KRas, a protein that is frequently mutated in cancer, is present on endosomes, independent of its activation state. The dynamics of GFP-KRas wild-type (WT) and constitutively active ...
Wang Caixia C College of Agronomy and Plant Protection, Qingdao Agricultural University, Qingdao 266109, P.R. China; Department of Plant Pathology, University of Kentucky, Lexington, KY 40546, - - 2014
Systemic acquired resistance (SAR) is a form of resistance that protects plants against a broad spectrum of secondary infections. However, exploiting SAR for the protection of agriculturally important plants warrants a thorough investigation of the mutual interrelationships among the various signals that mediate SAR. Here, we show that nitric oxide ...
Phong Ngo Dang ND International Rice Research Institute (IRRI), Los Baños, Philippines; University of Agriculture and Forestry, Ho Chi Minh City, Viet Nam. Electronic address: - - 2014
Acidic pollution can cause severe environmental consequences annually in coastal areas overlain with acid sulfate soils (ASS). A water quality model was used as an analytical tool for exploring the effects of water management options and other interventions on acidic pollution and salinity in Bac Lieu, a coastal province of ...
Evers Laurens J M LJ Koraalgroup, MFCG, Heel, The - - 2014
Patients with 22q11 deletion syndrome (22q11DS) have a high prevalence of psychiatric disorders and intellectual disability. At present the neurobiology underlying psychopathology in 22q11DS is still not understood. In the present study, we analyzed urinary serotonergic, dopaminergic and noradrenergic markers in 67 adults with 22q11DS. Levels of serotonin and the ...
Paik Jisun J University of Washington, United - - 2014
The regulation of testicular retinoic acid synthesis is crucial for understanding its role in spermatogenesis. Bisdichloroacetyldiamines (BDADs) strongly inhibit spermatogenesis. We previously reported that one of these compounds, WIN 18,446, potently inhibited spermatogenesis in rabbits by inhibiting retinoic acid synthesis. To understand how WIN 18,446 inhibits retinoic acid synthesis, we ...
Zeni Ana L B AL Department of Biochemistry, Biological Sciences Center, Federal University of Santa Catarina, Florianópolis, Santa Catarina, Brazil; Department of Natural Sciences, Natural and Exact Sciences Center, Regional University of Blumenau, Blumenau, Santa Catarina, - - 2014
Aloysia gratissima aqueous extract (AE) was investigated as a putative protective agent against quinolinic acid (QA)-induced seizures in mice and hippocampal cell damage. Additionally, AE and ferulic acid (FA), the major compound of AE, were tested against neurotoxicity evoked by glutamate or its N-methyl-D-aspartate receptor (NMDAR) agonist, QA on hippocampal ...
Zhou Yingjie - - 2014
Solid acids have received considerable attention as alternatives to traditional corrosive and hazardous homogeneous acids because of their advantages in practical applications, including their low corrosion of equipment and high catalytic activity and recyclability. In this work, a strong solid acid was prepared by anchoring thiol group terminated chains on ...
Woo Ji-Min JM Department of Food Science & Engineering, Ewha Womans University, Seoul, 120-750, Republic of - - 2014
Cellular responses of Saccharomyces cerevisiae to high temperatures of up to 42 °C during ethanol fermentation at a high glucose concentration (i.e., 100 g/L) were investigated. Increased temperature correlated with stimulated glucose uptake to produce not only the thermal protectant glycerol but also ethanol and acetic acid. Carbon flux into the tricarboxylic ...
Arsiningtyas Ines Septi IS a Division of Applied Bioscience, Graduate School of Agriculture, Hokkaido University , Kita-Ku, Sapporo 060-8589 , - - 2014
A promising approach for treating diabetes mellitus (DM) is to decrease postprandial hyperglycaemia by suppressing carbohydrate digestion using α-glucosidase inhibitors. Pluchea indica leaf extracts possess inhibitory activity against intestinal maltase. Enzyme assay-guided fractionation by chromatography yielded five active caffeoylquinic acid derivatives (1-5). Their structures were elucidated by mass spectrometry and ...
Raudone Lina L Department of Pharmacognosy Medical Academy, Lithuanian University of Health Sciences, Mickevičiaus str. 9, Kaunas, LT-44307, Lithuania. - - 2014
The mechanism of action of polyphenolic compounds is attributed to their antioxidant, anti-inflammatory, and anti-proliferative properties and their effects on subcellular signal transduction, cell cycle impairment and apoptosis. A raspberry (Rubus idaeus L.) fruit extract contains various antioxidant active compounds, particularly ellagic acid (EA); however the exact intracellular mechanism of ...
Zhou Xiaodong X Key Laboratory of Agricultural Meteorology, Jiangsu Province, Nanjing University of Information Science and Technology, Nanjing, 210044, People's Republic of - - 2014
Rising tropospheric ozone affects crop yield and quality. Rice protein concentration which is closely associated with eating/cooking quality is of critical importance to nutritional quality. The ozone effect on amino acids of rice grains were little known especially under different cultivation conditions. A hybrid rice cultivar Shanyou 63 was grown ...
Galano Annia - - 2014
Several aspects related to the antioxidant activity of ellagic acid were investigated using the Density Functional Theory. It was found that this compound is unusually versatile for protecting against the toxic effects caused by oxidative stress. Ellagic acid, in aqueous solution at physiological pH, is able of deactivating a wide ...
Ren Qiuyue Q Key Laboratory of Smart Drug Delivery (Fudan University), Ministry of Education, Department of Pharmaceutics, School of Pharmacy, Fudan University, Shanghai, 201203, - - 2014
In this study, the effect of the saturated fatty acid (FA) chain length in the oil phase on the behavior of Ibuprofen (IBU)-loaded transdermal microemulsion (ME) was evaluated in vitro, ex vivo, and in vivo. Three oils classified as long (LFA), medium (MFA), and short (SFA) chain length oils, Cremophor ...
De Simone Alessio A Dept. of Drug Discovery and Development, Istituto Italiano di Tecnologia, via Morego n.30, 16163 Genova, Italy. - - 2014
Combining computer-assisted drug design and synthetic efforts, we generated compounds with potent and balanced activities toward both D3 dopamine receptor and fatty acid amide hydrolase (FAAH) enzyme. By concurrently modulating these targets, our compounds hold great potential toward exerting a disease-modifying effect on nicotine addiction and other forms of compulsive ...
Jang Yu-Sin YS Metabolic and Biomolecular Engineering National Research Laboratory, Department of Chemical and Biomolecular Engineering, BioProcess Engineering Research Center, Center for Systems and Synthetic Biotechnology, Institute for the BioCentury, KAIST, Daejeon 305-701, Republic of - - 2014
A typical characteristic of the butyric acid-producing Clostridium is coproduction of both butyric and acetic acids. Increasing the butyric acid selectivity important for economical butyric acid production has been rather difficult in clostridia due to their complex metabolic pathways. In this work, Clostridium acetobutylicum was metabolically engineered for highly selective ...
Li Ying Y Faculty of Basic Medical Sciences, Chongqing Medical University, Chongqing 400016, China. Electronic address: - - 2014
Oleanolic acid, a triterpenoid contained in more than 1620 plants including various fruits and foodstuffs, has numerous metabolic effects, such as hepatoprotection. However, its underlying mechanisms remain poorly understood. Adipose tissue insulin resistance (Adipo-IR) may contribute to the development and progress of metabolic abnormalities through release of excessive free fatty ...
Chen Mingxun M College of Agriculture and Biotechnology, Zhejiang University, 866 Yu-Hang-Tang Road, Hangzhou 310058, PR - - 2014
Leaf senescence is an integrated response of leaf cells to developmental age and various internal and environmental signals. However, the role of gibberellins (GA) in leaf senescence is not clear. In the current study, we investigated the effect of DELLA on leaf senescence. Compared with the wild type (WT), leaf ...
Usaga Jessie J New York State Agricultural Experiment Station, Cornell University, Department of Food Science, 630 West North Street, Geneva, New York 14456, - - 2014
Numerous outbreaks involving fresh juices contaminated with Escherichia coli O157:H7 have occurred in the United States and around the world, raising concern for the safety of these products. Until now, only a few studies regarding the thermal tolerance of this pathogen in acidic juices over a wide range of pH ...
Kolev Joshua N JN Department of Chemistry, University of Rochester, Hutchison Hall, Rochester, NY 14620 - - 2014
The development of effective strategies for modulating the reactivity and selectivity of cytochrome P450 enzymes represents a key step toward expediting the use of these biocatalysts for synthetic applications. We have investigated the potential of unnatural amino acid mutagenesis to aid efforts in this direction. Four unnatural amino acids with ...
Krüssel Lena L 1 Institute for Plant Genetics, Leibniz University - - 2014
The sulfur dioxygenase ETHE1 catalyzes the oxidation of persulfides in the mitochondrial matrix and is essential for early embryo development in Arabidopsis thaliana. We investigated the biochemical and physiological function of ETHE1 in plant metabolism using recombinant Arabidopsis ETHE1 and three T-DNA insertion lines with 50-99 % decreased sulfur dioxygenase ...
Yun Soyoung - - 2014
The objective of this study is to evaluate the catalytic potential of Pt/Al-MCM-48 catalysts in hydroisomerization of n-dodecane. The effects of the Si/Al ratio and platinum loading on the acid characteristics of Al-MCM-48 and the catalytic performance in n-dodecane hydroisomerization were analyzed. The catalysts were characterized by X-ray diffraction, nitrogen ...
Alvarez-Munoz Diana - - 2014
Alcohol polyethoxylate (AEO) surfactants are widely used in household and industrial products , but the health effects arising from short term exposures to sublethal concentrations are unknown. A metabolomics approach was used to investigate the biotransformation and effects of exposure to sublethal concentrations of hexaethylene glycol monododecylether (C12EO6) in juvenile ...
Herbert Samantha L SL Behavior and Metabolism Laboratory, Champalimaud Neuroscience Programme, Champalimaud Centre for the Unknown, 1400-038 Lisbon, - - 2014
Animals need to ingest a full set of essential amino acids through their diet. A new study in Drosophila larvae describes how activation of the kinase GCN2 in three dopaminergic neurons mediates the rejection of amino-acid-imbalanced food.
Usami Yuki Y Department of Chemistry and Biological Science, College of Science and Engineering, Aoyama Gakuin University, Sagamihara, - - 2014
Leucine is a major amino acid in nutrients and proteins and is also an important precursor of higher alcohols during brewing. In Saccharomyces cerevisiae, leucine uptake is mediated by multiple amino acid permeases, including the high-affinity leucine permease Bap2. Although BAP2 transcription has been extensively analyzed, the mechanisms by which ...
Fonseca María Isabel MI Laboratorio de Biotecnología Molecular, Módulo de Bioquímica y Farmacia, Facultad de Ciencias Exactas Químicas y Naturales, UNaM, Av. Mariano Moreno 1375 (3300), Posadas, Misiones, Argentina, - - 2014
Nine aromatic compounds (caffeic acid, syringaldehyde, vanillic acid, guaiacol, vanillin, sinapic acid, syringol, syringic acid and ferulic acid) and four metallic compounds (CuSO4, AgNO3, MnSO4, and CaCl2) were tested for their ability to increase laccase (Lac) activity in the ligninolytic basidiomycete Phlebia brevispora BAFC 633. The addition of syringaldehyde, syringol, ...
Zhang Jun-Xia JX Department of Endocrinology and Metabolism, Southwest Hospital, Third Military Medical University, No. 30, Gaotanyanzheng Street, Shapingba District, Chongqing, 400038, - - 2014
Hyperuricemia is recently reported involving in various obesity-related cardiovascular disorders, especially hypertension. However, the underlying mechanisms are not completely understood. In the present study, we investigated whether uric acid upregulates renin-angiotensin system (RAS) expression in adipocytes. We also examined whether RAS activation plays a role in uric acid-induced oxidative stress ...
Li Weiguang W School of Municipal and Environmental Engineering, Harbin Institute of Technology, 73 Huanghe Road, Harbin, 150090, People's Republic of China, - - 2014
The effects of the organic loading rate (OLR) on the performance and the granular sludge characteristics of an expanded granular sludge bed (EGSB) reactor used for treating real traditional Chinese medicine (TCM) wastewater were investigated. Over 90 % of the COD removal by the EGSB reactor was observed at the OLRs ...
Karau Andreas A Evonik Industries AG, Business Line Health Care, Rodenbacher Chaussee 4, 63457, Hanau-Wolfgang, Germany, - - 2014
: Amino acids are key components of human and animal nutrition, both as part of a protein-containing diet, and as supplemented individual products. In the last 10 years there has been a marked move away from the extraction of amino acids from natural products, which has been replaced by efficient fermentation ...
Thalluri Kishore - - 2014
Ethyl 2-cyano-2-(4-nitrophenylsulfonyloxyimino)acetate (4-NBsOXY) mediated Lossen rearrangement and its application for the synthesis of ureas is demonstrated. Required hydroxamic acids for the Lossen rearrangement were synthesized from carboxylic acids using the same reagent. Finally, reaction of an amine with the produced isocyanate resulted in urea. Good yields without racemization were achieved ...
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