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Da-Costa-Rocha Inês I Centre for Pharmacognosy and Phytotherapy, UCL School of Pharmacy, University of London, 29-39 Brunswick Square, London WC1N 1AX, - - 2014
Hibiscus sabdariffa L. (Hs, roselle; Malvaceae) has been used traditionally as a food, in herbal drinks, in hot and cold beverages, as a flavouring agent in the food industry and as a herbal medicine. In vitro and in vivo studies as well as some clinical trials provide some evidence mostly ...
Sun Shu Yang SY School of Food Engineering, Ludong University, Yantai, Shandong 264025, PR China. Electronic address: - - 2014
This study examined the effect of mixed fermentation of non-Saccharomyces (Torulaspora delbrueckii ZYMAFLORE Alpha(TD n. Sacch) and Metschnikowia pulcherrima JS22) and Saccharomyces cerevisiae yeasts (D254 and EC1118) on the production of cherry wines, in comparison with commonly used mono-culture. Results obtained during AF demonstrated that negligible inhibitory effect was observed ...
Kumar Pardeep P a Department of Chemical and Biological Engineering , University of Saskatchewan , Saskatoon , - - 2014
Naphthenic acids are a complex mixture of organic components, some of which include saturated alkyl-substituted cycloaliphatic carboxylic acids and acyclic aliphatic acids. They are naturally found in hydrocarbon deposits like oil sand, petroleum, bitumen and crude oil. In this study, the oxidation of a relatively high molecular weight naphthenic acid ...
Holmes Emma P EP a Faculty of Land and Food Systems , The University of British Columbia , Vancouver , - - 2014
Chrysotile asbestos is considered an environmental health hazard. It is postulated that the surface of chrysotile, with its inherent positive charge and chemical content of trace transition metals within the mineral is a causative factor of the concern. Weathering may reduce the negative health effects of chrysotile asbestos, by alteration ...
Huang Yan - - 2014
Atopic dermatitis (AD) is the most common inflammatory skin disease in children. In the study, ultra high performance liquid chromatography-mass spectrometry was used to investigate serum metabolic abnormalities of AD children. Two batch fasting sera were collected from AD children and healthy control, one of them was for nontargeted metabolomics ...
Jiráková Anna A Dermatovenereology Department, 2nd Faculty of Medicine Charles University, Bulovka Hospital, Prague, Czech - - 2014
An adverse toxic reaction to the topical application of a 2% boric acid solution is described in a 2-year-old girl. Topical boric acid is licensed for use in children above the age of 10 in the Czech Republic. However, it can be bought over the counter and it is very ...
Chimentão R J RJ Department of Chemical Engineering, Universitat Rovira i Virgili Campus Sescelades, Av Paisos Catalans, 43007 Tarragona, Spain. Electronic address: - - 2014
The hydrolysis of dilute acid-pretreated cellulose was investigated in a conventional oven and under microwave heating. Two acids - sulfuric and oxalic - were studied. For both hydrothermal conditions (oven and microwave) the resultant total organic carbon (TOC) values obtained by the hydrolysis of the cellulose pretreated with sulfuric acid ...
Gopalakrishnan Lalitha L Centre for Nanotechnology & Advanced Biomaterials (CeNTAB), School of Chemical & Biotechnology, SASTRA University, Thanjavur - 613 401, Tamil Nadu, - - 2014
Ellagic acid, a naturally occurring polyphenol was encapsulated in chitosan particles prepared by ionotropic gelation and characterized for its physicochemical properties. A maximum encapsulation efficiency of 49% was achieved. The blood clotting time and clot retraction time were calculated for different concentrations of ellagic acid, chitosan and ellagic acid-encapsulated chitosan. ...
Sun Xue X Shanghai Diabetes Institute, Shanghai Clinical Center for Diabetes, Shanghai Key Clinical Center for Metabolic Disease, Shanghai Key Laboratory of Diabetes Mellitus, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai 200233, - - 2014
Aim:Genome-wide association studies have identified several novel loci associated with serum uric acid concentrations in individuals of European descent. In the current study, we aimed to evaluate the associations between these loci and serum uric acid concentrations in a Chinese population.Methods:Fourteen single nucleotide polymorphisms (SNPs) mapped in or near 11 ...
Wang Lihong L State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi 214122, China; School of Environmental and Civil Engineering, Jiangnan University, Wuxi 214122, - - 2014
Rare earth elements (REEs) pollution and acid rain are environmental issues, and their deleterious effects on plants attract worldwide attention. These two issues exist simultaneously in many regions, especially in some rice-growing areas. However, little is known about the combined effects of REEs and acid rain on plants. Here, the ...
Keller Julia - - 2014
A specific behavioural response of Caenorhabditis elegans, the rapid increase of locomotion in response to anoxia/reoxygenation called the O2-ON response, has been used to model key aspects of ischemia/reperfusion injury. A genetic suppressor screen demonstrated a direct causal role of CYP-13A12 in this response and suggested that CYP-eicosanoids, which in ...
Kızılşahin Sadi S a Department of Biology , Faculty of Science, Ege University , Izmir , - - 2014
The aim of this study was to determine in vitro synergistic efficacy of conjugated linoleic acid (CLA), oleic acid (OLA), safflower oil and taxol (Tax) cytotoxicity on human prostate cancer (PC3) cell line. To determine synergistic efficacy of oil combinations, PC3 treated with different doses of compounds alone and combined ...
Heleno Sandrina A SA Centro de Investigação de Montanha, Escola Superior Agrária, Bragança, Portugal. - - 2014
Despite the available data regarding antimicrobial activity of phenolic acids, studies dealing with the effects of their metabolites or derivatives are scarce. Therefore, the antimicrobial and demelanizing activities of Coprinopsis atramentaria extract, its organic acids, and methylated and glucuronated derivatives were evaluated. The antifungal activity was stronger than the antibacterial ...
Janke J Joel - - 2014
Fatty acid aggregation is important for a number of diverse applications: from origins of life research to industrial applications to health and disease. Experiments have characterized the phase behavior of oleic acid mixtures, but the molecular details are complex and hard to probe with many experiments. Coarse-grained molecular dynamics computer ...
Panda Achyut K AK Department of Chemistry, Veer Surendra Sai University of Technology, India - - 2014
Waste polypropylene was subjected to thermal degradation in the presence of kaolin and acid-treated kaolin, with different catalyst-to-plastics ratios, in a semi-batch reactor at a temperature range of 400-550°C to obtain optimized process conditions for the production of liquid fuels. The effects of process temperature, catalyst and feed composition on ...
Wang Sheng S Ministry of Education Key Laboratory of Protein Science, Tsinghua-Peking Joint Center for Life Sciences, Center for Structural Biology, School of Life Sciences and School of Medicine, Tsinghua University, Beijing 100084, - - 2014
Enteropathogenic bacteria, exemplified by Escherichia coli, rely on acid-resistance systems (ARs) to survive the acidic environment of the stomach. AR3 consumes intracellular protons through decarboxylation of arginine (Arg) in the cytoplasm and exchange of the reaction product agmatine (Agm) with extracellular Arg. The latter process is mediated by the Arg:Agm ...
Leyva Luis A LA Environmental Microbiology Group, Northwestern Center for Biological Research (CIBNOR), Av. IPN #195, La Paz, B.C.S., 23096, - - 2014
The relation between fatty acid accumulation, activity of acetyl-CoA carboxylase (ACC), and consequently lipid accumulation was studied in the microalgae Chlorella vulgaris co-immobilized with the plant growth-promoting bacterium Azospirillum brasilense under dark heterotrophic conditions with Na acetate as a carbon source. In C. vulgaris immobilized alone, cultivation experiments for 6 days ...
Springer Stevan A SA Glycobiology Research and Training Center, Department of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA, - - 2014
Human sialic acid biology is unusual and thought to be unique among mammals. Humans lack a functional cytidine monophosphate-N-acetylneuraminic acid hydroxylase (CMAH) protein and cannot synthesize the sugar Neu5Gc, an innate mammalian signal of self. Losing this sugar changed how humans interact with some of our deadliest pathogens: malaria, influenza, ...
Mai Ngoc Lan NL Department of Biological Engineering, Inha University, Incheon 402-751, Republic of - - 2014
Sugar fatty acid esters are bio-surfactants known for their non-toxic, non-ionic and high biodegradable properties. With great emulsifying and conditioning effects, sugar fatty acids are widely used in food, pharmaceutical and cosmetic industries. Biosynthesis of sugar fatty acid esters has attracted growing attention during the past decades. In this study, ...
Zeng Dan D Department of Chemical Engineering, School of Chemical Engineering and Technology, Xi'an Jiaotong University, Xi'an, 710049, - - 2014
An integrated process of supercritical methanol (SCM) and sodium methoxide catalyst was developed to produce fatty acid methyl esters (FAMEs) via continuous esterification from crude biodiesel. The crude biodiesel with high free fatty acid (FFA) content must be refined to reduce the acid value (AV) for meeting the quality standards. ...
Calestani D D IMEM-CNR, Parco Area delle Scienze 37/A, Parma-43124, - - 2014
High sensitivity zinc oxide (ZnO) tetrapods (TPs) have been functionalized by nucleating cadmium sulphide (CdS) nanoparticles (NPs) directly on their surface with a spotted coverage thanks to an optimized synthesis in dimethylformamide (DMF). The obtained hybrid coupled material has been used to realize a gas sensing device with a highly ...
Kim Mi Kyoung - - 2014
Quercetin-amino acid conjugates with alanine or glutamic acid moiety attached at 7-O and/or 3-O position of quercetin were prepared, and their multidrug resistance (MDR)-modulatory effects were evaluated. A quercetin-glutamic acid conjugate, 7-O-Glu-Q (3a), was as potent as verapamil in reversing MDR, and sensitized MDR MES-SA/Dx5 cells to various anticancer drugs ...
Bae Jin H JH School of Chemical and Biological Engineering, Seoul National University, Seoul, South - - 2014
A major problem of long-chain fatty acid (LCFA) hydroxylation using Escherichia coli is that FadD (long-chain fatty acyl-CoA synthetase), which is necessary for exogenous LCFA transport, also initiates cellular consumption of LCFA. In this study, an effective method to prevent the cellular consumption of LCFA without impairing its transport is ...
Kok Bernard P BP Department of Chemical Physiology, The Scripps Research Institute, 10550 N. Torrey Pines Road, La Jolla, CA 92037, - - 2014
Diterpene derivatives of the natural product acanthoic acid have potent anti-inflammatory effects in vivo. In this issue of Chemistry & Biolgy, Través and colleagues report that the primary molecular mechanism of action of diterpenes structurally related to acanthoic acid is the direct activation of PI3-kinase signaling in macrophages, which in turn ...
Lee Jong-Min JM Biorefinery Research Group & Industrial Biochemical Research Group, Korea Research Institute of Chemical Technology (KRICT), Jang-dong 100, Yuseong, Daejeon 305-600 - - 2014
Catalytic hydrogenation of organic carboxylic acids and their esters, for example, cellulosic ethanol from fermentation of acetic acid and hydrogenation of ethyl acetate is a promising possibility for future biorefinery concepts. A hybrid conversion process based on selective hydrogenation of butyric acid combined with fermentation of glucose has been developed ...
Klawitter Jost J iC42 Integrated Solutions in Systems Biology, University of Colorado, Aurora, CO, 80045-7503, USA, - - 2014
Stearoyl-CoA desaturase 1 (SCD1) plays a role in the development of obesity and related conditions, such as insulin resistance, and potentially also in neurological and heart diseases. The activity of SCD1 can be monitored using the desaturation index (DI), the ratio of product (16:1n-7 and 18:1n-9) to precursor (16:0 and ...
Hou Jia J Teagasc Food Research Center, Moorepark, Fermoy, Co. Cork, - - 2014
Washed (W) and nonwashed (NW) variants of standard (SCa) and reduced-calcium (RCa) Cheddar cheeses were made in triplicate, ripened for a 270-d period, and analyzed for composition and changes during maturation. Curd washing was applied to cheeses to give a target level of lactose plus lactic acid in cheese moisture ...
Worth Andrew J AJ University of Pennsylvania, United - - 2014
Rotenone is a naturally occurring mitochondrial complex I inhibitor with a known association to Parkinsonian phenotypes in both human populations and rodent models. Despite this finding, a clear mechanistic link between rotenone exposure and neuronal damage remains to be determined. Here, we report alterations to lipid metabolism in SH-SY5Y neuroblastoma ...
Hacıbekiroğlu Işıl I a Department of Analytical Chemistry , Faculty of Pharmacy, Bezmialem Vakif University , 34093 Istanbul , - - 2014
This study reports in vitro anticholinesterase, antioxidant and antimicrobial effects of the n-hexane, dichloromethane, ethanol and ethanol-water extracts prepared from Pistacia terebinthus L. fruits and Pistacia khinjuk Stocks seeds as well as their total phenolic and flavonoid contents, and fatty acid compositions. Ethanol and ethanol-water extracts of both species exhibited ...
Shinkai Hiroki H Animal Immune and Cell Biology Research Unit, Division of Animal Sciences, National Institute of Agrobiological Sciences, 1-2 Owashi, Tsukuba, Ibaraki 305-8634, - - 2014
Nucleotide-binding oligomerization domain 1 (NOD1) is a cytosolic pattern recognition receptor that recognizes γ-d-glutamyl-meso-diaminopimelic acid (iE-DAP), a component of bacterial peptidoglycan. NOD1 is thought to be involved in the immune homeostasis mediated by intestinal microbiota as well as the host defense against infection. In this study, we identified 12 synonymous ...
Chen Yan Y Department of Molecular and Cellular Medicine, Health Science Center, Texas A&M University, College Station, TX 77843, - - 2014
Natural foods contain not only nutrients, but also nonnutritious and potentially harmful chemicals. Thus, animals need to evaluate food content in order to make adequate feeding decisions. Here, we investigate the effects of acids on the taste neuron responses and on taste behavior of desirable, nutritious sugars and sugar/bitter compound mixtures ...
Bautista-Gallego J J Department of Food Biotechnology, Instituto de la Grasa (CSIC), Avda\ Padre García Tejero, n° 4, 41012, Seville, - - 2014
Zinc chloride has been used previously as a preservative in directly brined olives with promising results. However, this is the first time that the effects of ZnCl2 addition (0-1 g L(-1) ) on green Spanish-style table olive (Manzanilla cv.) packaging has been studied. The presence of ZnCl2 affected the physicochemical characteristics of ...
Peng Kun-Tao - - 2014
Microalgae are important primary producers in the marine ecosystem and excellent sources of lipids and other bioactive compounds. The marine diatom Phaeodactylum tricornutum accumulates eicosapentaenoic acid (EPA, 20:5n-3) as its major component of fatty acids. To improve the EPA production, delta 5 desaturase, which plays a role in EPA biosynthetic ...
Yao Xiao-Qin XQ The College of Life Sciences, Hebei University, Baoding, 071002, - - 2014
The paper studied UV-B-effects on biochemical parameters and active ingredients in flowers of Qi chrysanthemum and Huai chrysanthemum during the bud stage. The experiment included four UV-B radiation levels (CK, ambient UV-B; T1, T2 and T3 indicated a 5%, 10% and 15% increase in ambient UV-BBE , respectively) to determine ...
Sakai Hiromichi H Chiba University Graduate School of Science, - - 2014
Decreased expression of diacylglycerol (DG) kinase (DGK) δ in skeletal muscles is closely related to the pathogenesis of type 2 diabetes. To identify DG species that are phosphorylated by DGKδ in response to high-glucose stimulation, we investigated high glucose-dependent changes in phosphatidic acid (PA) molecular species in mouse C2C12 myoblasts ...
Pratelli Réjane R Plant Pathology, Physiology and Weed Science, Virginia Tech, Blacksburg, VA 24060, - - 2014
Amino acids play several critical roles in plants, from providing the building blocks of proteins to being essential metabolites interacting with many branches of metabolism. They are also important molecules that shuttle organic nitrogen through the plant. Because of this central role in nitrogen metabolism, amino acid biosynthesis, degradation, and ...
Martino Antonio DI AD Polymer Centre, Faculty of Technology, Tomas Bata University in Zlin, nam. T.G. Masaryka 275, 76272 Zlin, Czech Republic; Centre of polymer systems, University Institute, Nad Ovčírnou 3685, 76001 Zlin, Czech - - 2014
The aim of this work was to investigate the potential of an amphiphilic system comprising chitosan-grafted polylactide and carboxyl-functionalized polylactide acid as a carrier for the controlled release and co-release of two DNA alkylating drugs: doxorubicin and temozolomide. Polylactide and carboxyl-functionalized polylactide acid were obtained through direct melt polycondensation reaction, ...
Mimitsuka Takashi T New Frontiers Research Laboratories, Toray Industries, Inc., 6-10-1 Tebiro, Kamakura, Kanagawa 248-8555, Japan. Electronic address: - - 2014
Poly d-lactic acid is an important polymer because it improves the thermostability of poly l-lactic acid by stereo complex formation. To demonstrate potency of continuous fermentation using a membrane-integrated fermentation reactor (MFR) system, continuous fermentation using genetically modified Saccharomyces cerevisiae which produces d-lactic acid was performed at the low pH ...
Wittek Finni F Helmholtz Zentrum Muenchen, Department of Environmental Sciences, Institute of Biochemical Plant Pathology, Ingolstaedter Landstr. 1, D-85764 Neuherberg, - - 2014
Systemic acquired resistance (SAR) is a form of inducible disease resistance that depends on salicylic acid and its upstream regulator ENHANCED DISEASE SUSCEPTIBILITY1 (EDS1). Although local Arabidopsis thaliana defence responses activated by the Pseudomonas syringae effector protein AvrRpm1 are intact in eds1 mutant plants, SAR signal generation is abolished. Here, ...
Dichlberger Andrea A Wihuri Research Institute, 00290 Helsinki, - - 2014
Human mast cells (MCs) contain TG-rich cytoplasmic lipid droplets (LDs) with high arachidonic acid (AA) content. Here, we investigated the functional role of adipose TG lipase (ATGL) in TG hydrolysis and the ensuing release of AA as substrate for eicosanoid generation by activated human primary MCs in culture. Silencing of ...
Zhang Xi X College of Biosystems Engineering and Food Science, Zhejiang University, Hangzhou, 310058, China; Zhejiang Key Laboratory for Agro-Food Processing, Zhejiang University, Hangzhou, 310058, - - 2014
Sugar medium chain fatty acid esters, a new type of biodegradable, nontoxic, nonirritant, and nonionic surfactant with proven antimicrobial activity. Various sugar medium-chain fatty monoesters were prepared enzymatically using Lipozyme TLIM in organic solvent. The properties such as surface tension, antimicrobial activity, and ability to foam, emulsify, and stabilize emulsions ...
Robinson Sarah L SL West Virginia University, Division of Plant and Soil Sciences, Genetics and Developmental Biology Program, Morgantown, WV - - 2014
Different lineages of fungi produce distinct classes of ergot alkaloids. Lysergic acid-derived ergot alkaloids produced by fungi in the Clavicipitaceae are particularly important in agriculture and medicine. The pathway to lysergic acid is partly elucidated, but the gene encoding the enzyme that oxidizes the intermediate agroclavine is unknown. We investigated ...
Mühlig Anna A Abteilung Mikrobiologie (ZIEL), Technische Universität München, Freising, - - 2014
The antimicrobial action of the curing agent sodium nitrite (NaNO2), which is added as a preservative to raw meat products, depends on its conversion to nitric oxide and other reactive nitrogen species under acidic conditions. In this study, we applied RNA-sequencing to analyze the acidified NaNO2 shock and adaptive response ...
Bravo Karent K Grupo de Investigación en Sustancias Bioactivas, Facultad de Química Farmacéutica, Universidad de Antioquia UdeA, Calle 70 No. 52-21, Medellín, - - 2014
Cape gooseberry (Physalis peruviana) is an exotic fruit with high valued for its organoleptic properties and bioactive compounds. Considering that the presence of phenolics and ascorbic acid could contribute to their functional capacity, it is important to investigate the quality parameters and bioactive contents and functional properties with respect to ...
van Zanten Gabriella C GC Department of Food Science, Faculty of Science, University of Copenhagen, Frederiksberg, Denmark; Enzyme and Protein Chemistry, Department of Systems Biology, Technical University of Copenhagen, Kgs. Lyngby, - - 2014
Probiotics, prebiotics and combinations thereof, i.e. synbiotics, have been reported to modulate gut microbiota of humans. In the present study effects of a novel synbiotic on the composition and metabolic activity of human gut microbiota were investigated. Healthy volunteers (n =18) were enrolled in a double-blinded, randomized, placebo-controlled crossover study ...
Hoogeveen Ellen K EK Departments of Internal Medicine and Nephrology - - 2014
Kidney function gradually decreases with age, and myocardial infarction accelerates this deterioration. Omega-3 (n-3) fatty acids may slow down the decline of kidney function. The effect of marine and plant-derived n-3 fatty acids on kidney function in patients after myocardial infarction was examined. In the Alpha Omega Trial, 2344 patients ...
Shen Peihong P College of Life Science and Technology of Guangxi University, Nanning, Guangxi, China; State Key Laboratory for Conservation and Utilization of Agricultural Bioresources in the Subtropics, Nanning, Guangxi, - - 2014
Anisic acid, the precursor of a variety of food flavors and industrial raw materials, can be bioconversed from anethole which extracted from star anise fruits. WGB31 strain with anisic acid molar production rate of 10.25% was isolated and identified as Burkholderia sp. Three significant influential factors, namely, glucose concentration, initial ...
Wu Xiao-Hui XH Tianjin Key Laboratory on Technologies Enabling Development of Clinical, Therapeutics and Diagnostics, College of Pharmacy, Tianjin Medical University, Tianjin, 300070, China; Tang Center for Herbal Medicine Research, University of Chicago, Chicago, IL, 60637, - - 2014
The roots and rhizomes of Smilax riparia, called 'Niu-Wei-Cai' in traditional Chinese medicine, are believed to be effective in treating the symptoms of gout. However, the active constituents and their uricosuric mechanisms are unknown. In this study, we isolated two steroidal glycosides, named smilaxchinoside A and smilaxchinoside C, from the ...
Patil Renukadevi - - 2014
Lysophosphatidic acid (LPA) is a growth factor-like mediator and a ligand for multiple GPCR. The LPA2 GPCR mediates antiapoptotic and mucosal barrier-protective effects in the gut. We synthesized sulfamoyl benzoic acid (SBA) analogs that are the first specific agonists of LPA2, some with subnanomolar activity. We also developed an experimental ...
Purcell Robert R From Comparative Biomedical Sciences, Royal Veterinary College (RP, SHL, KMB, and CPDW-J) and Diabetes & Nutritional Sciences Division (WLH), King's College London, London, United - - 2014
Eicosapentaenoic acid (EPA) plus docosahexaenoic acid (DHA) supplementation has beneficial cardiovascular effects, but postprandial influences of these individual fatty acids are unclear. The primary objective was to determine the vascular effects of EPA + DHA compared with DHA only during postprandial lipemia relative to control high-oleic acid meals; the secondary ...
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