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Da-Costa-Rocha Inês I Centre for Pharmacognosy and Phytotherapy, UCL School of Pharmacy, University of London, 29-39 Brunswick Square, London WC1N 1AX, - - 2014
Hibiscus sabdariffa L. (Hs, roselle; Malvaceae) has been used traditionally as a food, in herbal drinks, in hot and cold beverages, as a flavouring agent in the food industry and as a herbal medicine. In vitro and in vivo studies as well as some clinical trials provide some evidence mostly ...
Holmes Emma P EP a Faculty of Land and Food Systems , The University of British Columbia , Vancouver , - - 2014
Chrysotile asbestos is considered an environmental health hazard. It is postulated that the surface of chrysotile, with its inherent positive charge and chemical content of trace transition metals within the mineral is a causative factor of the concern. Weathering may reduce the negative health effects of chrysotile asbestos, by alteration ...
Chimentão R J RJ Department of Chemical Engineering, Universitat Rovira i Virgili Campus Sescelades, Av Paisos Catalans, 43007 Tarragona, Spain. Electronic address: - - 2014
The hydrolysis of dilute acid-pretreated cellulose was investigated in a conventional oven and under microwave heating. Two acids - sulfuric and oxalic - were studied. For both hydrothermal conditions (oven and microwave) the resultant total organic carbon (TOC) values obtained by the hydrolysis of the cellulose pretreated with sulfuric acid ...
Gopalakrishnan Lalitha L Centre for Nanotechnology & Advanced Biomaterials (CeNTAB), School of Chemical & Biotechnology, SASTRA University, Thanjavur - 613 401, Tamil Nadu, - - 2014
Ellagic acid, a naturally occurring polyphenol was encapsulated in chitosan particles prepared by ionotropic gelation and characterized for its physicochemical properties. A maximum encapsulation efficiency of 49% was achieved. The blood clotting time and clot retraction time were calculated for different concentrations of ellagic acid, chitosan and ellagic acid-encapsulated chitosan. ...
Wang Lihong L State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi 214122, China; School of Environmental and Civil Engineering, Jiangnan University, Wuxi 214122, - - 2014
Rare earth elements (REEs) pollution and acid rain are environmental issues, and their deleterious effects on plants attract worldwide attention. These two issues exist simultaneously in many regions, especially in some rice-growing areas. However, little is known about the combined effects of REEs and acid rain on plants. Here, the ...
Güngör Irfan I Department of Anesthesiology and Reanimation, Medical Faculty of Gazi University, 06500 Beşevler, Ankara, Turkey. - - 2014
In this study, we aimed to study the anti-apoptotic effects of hyaluronic acid on the apoptotic effects of bupivacaine in cultured rat chondrocytes in a time and dose-dependent manner. The rat chondrocytes were treated with 7.69 µM, 76.9 µM, and 384.5 µM bupivacaine and 50 µg/ml hyaluronic acid concentrations for ...
Oyedeji Opeoluwa O OO Department of Chemistry, University of Fort Hare, Alice, South Africa ooyedeji@ufh.ac.za - - 2014
Oleanolic acid is a triterpenoid that has shown in vitro cytotoxic activity against human tumour cells and is known to be present in many higher plants. Oleanolic acid is known to have some biological potential including anticancer property. Oleanolic acid was isolated from the ethyl acetate fraction of Syzygium aromaticum ...
Hu Huiqing H State Key Laboratory of Food Science and Technology, School of Environmental and Civil Engineering, Jiangnan University, Wuxi, 214122, - - 2014
To explore how lead (Pb) and acid rain simultaneously affect plants, the combined effects of Pb and acid rain on the chlorophyll content, chlorophyll fluorescence reaction, Hill reaction rate, and Mg(2+)-ATPase activity in soybean seedlings were investigated. The results indicated that, when soybean seedlings were treated with Pb or acid ...
Stanley Jill J School of Biomolecular and Physical Science, Griffith University, Nathan, QLD 4111, Australia and The New Zealand Institute for Plant & Food Research Ltd, RD 1, Alexandra 9391, New - - 2014
Improving apricot fruit quality delivered to consumers is key to ensuring a successful apricot industry. Previous studies have focused on effects of either soluble solids content (SSC) or fruit firmness on consumer preferences and results have been equivocal. This study evaluated the effects of crop load and harvest maturity, how ...
Heesen M M Department of Anaesthesia, Klinikum Bamberg, Bamberg, - - 2014
Tranexamic acid is effective in reducing blood loss during various types of surgery and after trauma. No compelling evidence has yet been presented for post-partum haemorrhage. A systematic literature search of relevant databases was performed to identify trials that assessed blood loss and transfusion incidence after tranexamic acid administration for ...
Becker Axel - - 2014
Valerian is commonly used for the treatment of insomnia and anxiety. Valerian extracts allosterically modulate GABA-A receptors and induced an anxiolytic activity. This activity is closely related to valerenic acid. In the present experiments it was investigated whether acetoxy valerenic acid may interfere with the anxiolytic action of valerenic acid. ...
Kumar Muthukannan Satheesh MS Division of Microbial Biodiversity and Bioenergy, Department of Microbiology, School of Life Sciences, Bharathidasan University, Tiruchirappalli, 620 024, Tamil Nadu, India; Department of Environmental Engineering, Yonsei University, Wonju, 220 710, Republic of - - 2014
The study investigated the effect of pesticide chlorpyrifos on a freshwater cyanobacterium Chroococcus turgidus NTMS12. The changes in chlorophyll-a, proline, superoxide dismutase, catalase activities and fatty acids composition of the test organism were analyzed. Organism was grown at 6, 9 and 12 mg l(-1) of chlorpyrifos and based on the ...
Hou Xue-Dan XD State Key Laboratory of Pulp and Paper Engineering, College of Light Industry and Food Sciences, South China University of Technology, Guangzhou 510640, China; College of Biosciences and Bioengineering, South China University of Technology, Guangzhou 510006, - - 2014
In this work, 28 cholinium ILs, most of which are good solvents for dissolving lignin, were used for rice straw pretreatment to improve subsequent enzymatic hydrolysis. The anion exerted a significant effect on the pretreatment effectiveness of the IL as well as the subsequent enzymatic hydrolysis efficiency of rice straw ...
Paczkowski Melissa M M Paczkowski, Research, National Foundation for Fertility Research, Lone Tree, United - - 2014
Fatty acid oxidation (FAO) is essential for oocyte maturation in mice. The objective of this experiment was to determine the effect of etomoxir (a FAO inhibitor; 100 μM), carnitine (1 mM), and palmitic acid (1 or 100 μM) during maturation on metabolism and gene expression of the oocyte and cumulus ...
Moro Artur J - - 2014
The kinetics and thermodynamics of the 2,6-bis(2-hydroxybenzilidene)cyclohexanone chemical reactions network was studied at different pH values using NMR, UV-Vis, continuous irradiation and flash photolysis. The chemical behavior of the system partially resembles with anthocyanins and their analogue compounds. 2,6-Bis(2-hydroxybenzilidene)cyclohexanone exhibits slow color change from yellow to red styrylflavylium under extreme ...
Maddipati Krishna Rao KR Bioactive Lipids Research Program, Department of Pathology, Lipidomics Core Facility, and Department of Obstetrics and Gynecology, Wayne State University School of Medicine, Detroit, Michigan, USA;Bioactive Lipids Research Program, Department of Pathology, Lipidomics Core Facility, and Department of Obstetrics and Gynecology, Wayne State University School of Medicine, Detroit, Michigan, USA; - - 2014
Lipid mediators play an important role in reproductive biology, especially, in parturition. Enhanced biosynthesis of eicosanoids, such as prostaglandin E2 (PGE2) and PGF2α, precedes the onset of labor as a result of increased expression of inducible cyclooxygenase 2 (COX-2) in placental tissues. Metabolism of arachidonic acid results in bioactive lipid ...
Chen Xiulai X State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi 214122, China; Key Laboratory of Industrial Biotechnology, Ministry of Education, Jiangnan University, Wuxi 214122, China; Laboratory of Food Microbial-Manufacturing Engineering, Jiangnan University, Wuxi 214122, - - 2014
A multi-vitamin auxotrophic Torulopsis glabrata strain, a pyruvate producer, was further engineered to produce fumaric acid. Using the genome-scale metabolic model iNX804 of T. glabrata, four fumaric acid biosynthetic pathways, involving the four cytosolic enzymes, argininosuccinate lyase (ASL), adenylosuccinate lyase (ADSL), fumarylacetoacetase (FAA) and fumarase (FUM1), were found. Athough single ...
Sanematsu Keisuke K Kyushu University, - - 2014
Gymnemic acids are triterpene glycosides that selectively suppress taste responses to various sweet substances in humans, but not in mice. This sweet-suppressing effect of gymnemic acids is diminished by rinsing the tongue with γ-cyclodextrin (γ-CD). However, little is known about the molecular mechanisms underlying sweet-suppressing effect of gymnemic acids and ...
Gou Qian Q Dipartimento di Chimica "G. Ciamician", Università di Bologna, Via Selmi 2, I-40126 Bologna (Italy), Fax: - - 2014
We report the rotational spectra of two conformers of the acetic acid-difluoroacetic acid adduct (CH3 COOH-CHF2 COOH) and supply information on its internal dynamics. The two conformers differ from each other, depending on the trans or gauche orientation of the terminal CHF2 group. Both conformers display splittings of the rotational ...
Kowshika J - - 2014
Background: Blocking vascular endothelial growth factor (VEGF) mediated tumor angiogenesis by phytochemicals has emerged as an attractive strategy for cancer prevention and therapy. Methods: We investigated the anti-angiogenic effects of ellagic acid in a hamster model of oral oncogenesis by examining the transcript and protein expression of hypoxia-inducible factor-1alpha (HIF-1a), ...
Allen Scott E - - 2014
The N-heterocyclic carbene and hydroxamic acid co-catalyzed kinetic resolution of cyclic amines generates enantioenriched amines and amides with selectivity factors up to 127. In this report, a quantum mechanical study of the reaction mechanism indicates that the selectivity-determining aminolysis step occurs via a novel concerted pathway in which the hydroxamic ...
Fang Weiwei W Department of Chemistry, Fudan University, 220 Handan Road, 200433, Shanghai, China. - - 2014
By using metallo-hydrogel as a new platform, a simple and straightforward selective visual discrimination of cysteine, homocysteine and glutathione from each other as well as from other amino acids has been realized.
Gondor Orsolya Kinga OK Agricultural Institute, Centre for Agricultural Research, Hungarian Academy of Sciences, H-2462 Martonvásár, POB 19, - - 2014
UV-B radiation may have either a positive or negative impact under the same conditions in wheat, depending on the type of secondary abiotic stressor: Cd or drought. Supplemental UV-B prevented the wilting and leaf rolling induced by PEG treatment. In contrast, combined UV-B and Cd treatment resulted in pronounced oxidative ...
Inada Takefumi T Department of Anesthesiology, Kansai Medical University , Osaka , - - 2014
Abstract Propofol is an intravenous drug widely used for anesthesia and sedation. Previously, propofol was shown to inhibit cyclo-oxygenase (COX) and 5-lipoxygenase (5-LOX) activities. Because these enzyme-inhibiting effects have only been demonstrated in vitro, this study sought to ascertain whether similar effects might also be observed in vivo. In the ...
Kelley Nirvair S NS 1 Arizona College of Osteopathic Medicine, Midwestern University , Glendale, - - 2014
Abstract Background: Despite many known health benefits of n-3 polyunsaturated fatty acids (PUFA), there is a concern that their high degree of unsaturation may actually increase oxidative stress, lipid peroxidation (LPO), and chronic inflammatory diseases. Methods: In this review, we have analyzed results from published human studies regarding the effects ...
Liljeblad Jonathan F D JF School of Chemistry, Division of Surface and Corrosion Science, KTH Royal Institute of Technology, SE-100 44 Stockholm, Sweden. - - 2014
The morphology and molecular conformation of Langmuir-Blodgett deposited and floating monolayers of a selection of straight chain (eicosanoic acid, EA), iso (19-methyl eicosanoic acid, 19-MEA), and anteiso (18-methyl eicosanoic acid, 18-MEA) fatty acids have been investigated by Vibrational Sum Frequency Spectroscopy (VSFS), AFM imaging, and the Langmuir trough. While the ...
Chen Rui R State Key Laboratory of Biomembrane and Membrane Biotechnology, Tsinghua University-Peking University Joint Center for Life Sciences, School of Life Sciences, Tsinghua University, Beijing 100084, - - 2014
Organisms have evolved elaborate mechanisms to adjust intracellular nutrient levels in response to fluctuating availability of exogenous nutrients. During starvation, cells can enhance amino acid uptake and synthesis through the general amino acid control (GAAC) pathway, whereas nonessential cellular contents are recycled by autophagy. How these two pathways are coordinated ...
Luo Xu-Ying XY State Key Laboratory of Food Science and Technology, Nanchang Univ, Nanchang, 330047, China; Engineering Research Center of Biomass Conversion, Ministry of Education, Nanchang Univ, Nanchang, 330047, - - 2014
To identify inhibitors for lysinoalanine formation in preserved egg, sulfhydryl compounds (glutathione, L-cysteine), carbohydrates (sucrose, D-glucose, maltose), organic acids (L-ascorbic acid, citric acid, DL-malic acid, lactic acid), and sodium sulfite were individually added at different concentrations to a pickling solution to prepare preserved eggs. Lysinoalanine formation as an index of ...
Wakashima Takeshi T Hokkaido University, - - 2014
The sphingolipid metabolite sphingosine-1-phosphate (S1P) functions as a lipid mediator and as a key intermediate of the sole sphingolipid-to-glycerophospholipid metabolic pathway (S1P metabolic pathway). In this pathway, S1P is converted to palmitoyl-CoA through 4 reactions, then incorporated mainly into glycerophospholipids. Although most of the genes responsible for the S1P metabolic ...
Jang Eungyeong - - 2014
Artemisia capillaris (AC) has been recognized as one of the promising candidates for hepatoprotective, hypoglycemic, hypolipidemic, antiobesitic and anti-inflammatory therapeutic effectiveness. This study evaluated the inherent mechanism and anti-apoptotic activity of 30% ethanol extract of AC (AC extract) 100 mug/ml on free fatty acids (FFAs)-induced HepG2 cellular steatosis and lipoapoptosis. ...
Arunagiri Pandiyan P Department of Biochemistry and Biotechnology, Faculty of Science, Annamalai University, Annamalainagar, Tamil Nadu, 608 002, - - 2014
Manic episode in bipolar disorder (BD) was evaluated in the present study with supplementation of omega-3 fatty acids in combination with aripiprazole and lithium on methylphenidate (MPD)-induced manic mice model. Administration of MPD 5 mg/kg bw intraperitoneally (i.p.) caused increase in oxidative stress in mice brain. To retract this effect, supplementation ...
van Beilen J W A JW Molecular Biology & Microbial Food Safety, Swammerdam Institute for Life Sciences, University of Amsterdam, The - - 2014
Sorbic and acetic acid are amongst the most commonly used weak organic acid preservatives to improve the microbiological stability of foods. Both have a similar pKa value but sorbic acid is a far more potent preservative. Weak organic acids are most effective at low pH. Under these circumstances, they are ...
Dolce Vincenza V Department of Pharmacy, Health and Nutritional Sciences, University of Calabria, Arcavacata di Rende Cosenza, - - 2014
The citrate carrier (CiC), characteristic of animals, and the dicarboxylate-tricarboxylate carrier (DTC), characteristic of plants and protozoa, belong to the mitochondrial carrier protein family whose members are responsible for the exchange of metabolites, cofactors, and nucleotides between the cytoplasm and the mitochondrial matrix. Most of the functional data on these ...
Torres-Contreras Ana Mariel - - 2014
Potato tubers under wounding stress synthesize chlorogenic acid isomers, which are phenolic compounds that prevent chronic diseases. Phenolic compounds biosynthesis in plants requires aromatic amino acids that are produced from sugars. Therefore, in the present study, we hypothesized that the wound-induced accumulation of chlorogenic acid isomers in potatoes could be ...
Ruan Weimei W a Department of Chemistry , National University of Singapore , Singapore , - - 2014
The response surface methodology was used to optimise the extraction conditions of Ganoderma lucidum based on a Box-Behnken design. A quadratic model sufficiently simulated the response of ganoderic acid H with a determination coefficient (R(2)) of 0.98. The optimal condition for extracting triterpenoids was determined to be 100.00% ethanol at ...
Honcharenko Dmytro D Department of Biosciences and Nutrition, Karolinska Institutet, S-14183 Huddinge, Sweden. Roger.Stromberg@ki.se - - 2014
Peptide-like compounds containing an arginine have been shown to bind and stabilize the central helix of the Alzheimer's disease related amyloid-β peptide (Aβ) in an α-helical conformation, thereby delaying its aggregation into cytotoxic species. Here we study a novel Aβ targeting ligand AEDabDab containing the triamino acid, N(γ)-(2-aminoethyl)-2,4-diaminobutanoic (AEDab) acid. ...
Bartkiene Elena E Lithuanian University of Health Sciences, Tilzes str. 18, 47181, Kaunas, - - 2014
The ability of bacteriocin-like inhibitory substances (BLIS) producing lactic acid bacteria to degrade biogenic amines as well as to produce L(+) and D(-)-lactic acid during solid state fermentation (SSF) of lupine and soybean was investigated. In addition, the protein digestibility and formation of organic acids during SSF of legume were ...
Sun Xinxiao X State Key Laboratory of Chemical Resource Engineering, Beijing University of Chemical Technology, Beijing, China - - 2014
Non-oxidative decarboxylases belong to a unique enzyme family that does not require any cofactors. Here we report the characterization of a 2,3-dihydroxybenzoic acid (2,3-DHBA) decarboxylase (BDC) from Klebsiella pneumoniae and explore its application on the production of muconic acid. The enzyme properties were systematically studied, including the optimal temperature and ...
Fernández-Galilea Marta M Department of Nutrition, Food Science and Physiology, University of Navarra, Pamplona, - - 2014
α-Lipoic acid (α-LA) is a natural occurring antioxidant with beneficial effects on obesity. The aim of this study was to investigate the putative effects of α-LA on triglyceride accumulation and lipogenesis in subcutaneous adipocytes from overweight/obese subjects and to determine the potential mechanisms involved. Fully differentiated human subcutaneous adipocytes were ...
Zhao Mouming - - 2014
This study aimed to explore the potential of polished adlay, brown adlay, adlay bran and adlay hull to prevent and treat hyperuricemia. Brown adlay extract effectively decreased the serum uric acid levels of oxonate-induced hyperuricemic rats. Free and bound phenolic extracts from these materials contained significant amounts of phenolics, with ...
Malhotra Rajesh R Department of Chemistry, Guru Jambheshwar University of Science and Technology, Hisar, Haryana 125001, - - 2014
First regioselective ring opening of serine derived cyclic sulfamidate by hard nucleophiles like ArONa is developed, where β-elimination of serine sulfamidate ester by stronger nucleophiles is overcome by reversal of the electronic effect of the carboxylate anion. This method provides easy and direct access to a variety of N-Boc- and ...
Sethi Ankur A 1Rosalind Franklin University of Medicine and Science, North Chicago, IL; and 2Department of Medicine, Wright Center of Graduate Medical Education, Scranton, - - 2014
During last 2 decades, multiple studies have evaluated omega-3 polyunsaturated fatty acids (ω-3 PUFA) supplementation for cardiovascular prevention. The benefit found in previous studies was not demonstrated in more contemporary trials. We aimed to investigate effect of study characteristics, particularly concomitant statin therapy on results of randomized controlled trials. We ...
Li Jing J CAS Key Laboratory of Plant Germplasm Enhancement and Specialty Agriculture, Wuhan Botanical Garden, Chinese Academy of Sciences, Wuhan, 430074, China; University of Chinese Academy of Sciences, Beijing, 100049, - - 2014
Betulinic acid is a plant derived triterpenoid with beneficial effects for anti-tumor and anti-human immunodeficiency virus treatments. In Saccharomyces cerevisiae, we previously constructed the betulinic acid biosynthetic pathway, in which several enzymes function in a NADPH or oxygen-dependent manner. To seek whether the intracellular supply of the NADPH/oxygen of S. cerevisiae ...
Ke Haihua - - 2014
Efficient bis(phosphine)nickel catalyzed cross-couplings of diarylborinic acids with aryl chlorides, tosylates and sulfamates have been effected with an assistance of N-heterocyclic carbene (NHC) generated in situ from N,N'-dialkylimidazoliums, e.g. N-butyl-N'-methylimidazolium bromide ([Bmim]Br), in toluene using K3PO43H2O as base. In contrast to bis(NHC)nickel-catalyzed conventional Suzuki coupling of arylboronic acids, mono(NHC)bis(phosphine)nickel species ...
Snapp Anna R AR Department of Plant Sciences and Plant Pathology, Montana State University, Bozeman, MT, 59717-3150, - - 2014
Co-expression of a lesquerella fatty acid elongase and the castor fatty acid hydroxylase in camelina results in higher hydroxy fatty acid containing seeds with normal oil content and viability. Producing hydroxy fatty acids (HFA) in oilseed crops has been a long-standing goal to replace castor oil as a renewable source ...
Kapdi Anant R AR Department of Chemistry, Institute of Chemical Technology, Matunga, Mumbai-400019, - - 2014
Direct transmetallation between palladacyclic complexes and arylboronic acid occurs to give isolable transmetallation products. In THF, the reaction occurs <0.5 h. Prolonged reaction leads to the generation of a dinuclear Pd complex bearing bridging μ-hydroxo and μ-acetoxy ligands. Insight into precatalyst activation for Suzuki-Miyaura cross-couplings mediated by palladacycles has been ...
Arcan Iskender - - 2014
To develop edible films having controlled release properties for multiple bioactive compounds hydrophobicity and morphology of zein films were modified by blending zein with oleic (OLE) (C18:1)Δ9, linoleic (LIN) (C18:2)Δ9,12 or lauric (LAU) (C12) acids in presence of lecithin (LEC). The blend zein films showed 2 to 8.5 and 1.6 ...
Giedyk Maciej M Institute of Organic Chemistry PAS, Kasprzaka 44/52, 01-224 Warsaw (Poland), Fax: - - 2014
Specially designed B-ring-modified cobalamin derivatives were synthesized and tested as potential activators of soluble guanylyl cyclase (sGC). Herein, we disclose the influence of substituents at the c- and d-positions in hydrophilic and hydrophobic cobyrinic acid derivatives on their capacities to activate sGC. The presence of the amide group at c-/d-position ...
Tomaszewska Ludwika L Department of Biotechnology and Food Microbiology, Wrocław University of Environmental and Life Sciences, Chełmońskiego Str. 37/41, 51-630, Wrocław, - - 2014
Citric acid and erythritol biosynthesis from pure and crude glycerol by three acetate-negative mutants of Yarrowia lipolytica yeast was investigated in batch cultures in a wide pH range (3.0-6.5). Citric acid biosynthesis was the most effective at pH 5.0-5.5 in the case of Wratislavia 1.31 and Wratislavia AWG7. With a ...
Li Jianmei J Key Laboratory of Green Chemistry and Technology, Ministry of Education, College of Chemistry, Sichuan University, 29 Wangjiang Road, Chengdu, Sichuan, 610064 (PR China), Fax: - - 2014
Increased energy consumption and environmental concerns have driven efforts to produce chemicals from renewable biomass with high selectivity. Here, the selective conversion of cellulose in corncob residue, a process waste from the production of xylose, to levulinic acid was carried out using AlCl3 as catalyst and NaCl as promoter by ...
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