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Da-Costa-Rocha Inês I Centre for Pharmacognosy and Phytotherapy, UCL School of Pharmacy, University of London, 29-39 Brunswick Square, London WC1N 1AX, - - 2014
Hibiscus sabdariffa L. (Hs, roselle; Malvaceae) has been used traditionally as a food, in herbal drinks, in hot and cold beverages, as a flavouring agent in the food industry and as a herbal medicine. In vitro and in vivo studies as well as some clinical trials provide some evidence mostly ...
Chimentão R J RJ Department of Chemical Engineering, Universitat Rovira i Virgili Campus Sescelades, Av Paisos Catalans, 43007 Tarragona, Spain. Electronic address: - - 2014
The hydrolysis of dilute acid-pretreated cellulose was investigated in a conventional oven and under microwave heating. Two acids - sulfuric and oxalic - were studied. For both hydrothermal conditions (oven and microwave) the resultant total organic carbon (TOC) values obtained by the hydrolysis of the cellulose pretreated with sulfuric acid ...
Gopalakrishnan Lalitha L Centre for Nanotechnology & Advanced Biomaterials (CeNTAB), School of Chemical & Biotechnology, SASTRA University, Thanjavur - 613 401, Tamil Nadu, - - 2014
Ellagic acid, a naturally occurring polyphenol was encapsulated in chitosan particles prepared by ionotropic gelation and characterized for its physicochemical properties. A maximum encapsulation efficiency of 49% was achieved. The blood clotting time and clot retraction time were calculated for different concentrations of ellagic acid, chitosan and ellagic acid-encapsulated chitosan. ...
Wang Lihong L State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi 214122, China; School of Environmental and Civil Engineering, Jiangnan University, Wuxi 214122, - - 2014
Rare earth elements (REEs) pollution and acid rain are environmental issues, and their deleterious effects on plants attract worldwide attention. These two issues exist simultaneously in many regions, especially in some rice-growing areas. However, little is known about the combined effects of REEs and acid rain on plants. Here, the ...
Güngör Irfan I Department of Anesthesiology and Reanimation, Medical Faculty of Gazi University, 06500 Beşevler, Ankara, Turkey. - - 2014
In this study, we aimed to study the anti-apoptotic effects of hyaluronic acid on the apoptotic effects of bupivacaine in cultured rat chondrocytes in a time and dose-dependent manner. The rat chondrocytes were treated with 7.69 µM, 76.9 µM, and 384.5 µM bupivacaine and 50 µg/ml hyaluronic acid concentrations for ...
Allen Scott E - - 2014
The N-heterocyclic carbene and hydroxamic acid co-catalyzed kinetic resolution of cyclic amines generates enantioenriched amines and amides with selectivity factors up to 127. In this report, a quantum mechanical study of the reaction mechanism indicates that the selectivity-determining aminolysis step occurs via a novel concerted pathway in which the hydroxamic ...
Fang Weiwei W Department of Chemistry, Fudan University, 220 Handan Road, 200433, Shanghai, China. - - 2014
By using metallo-hydrogel as a new platform, a simple and straightforward selective visual discrimination of cysteine, homocysteine and glutathione from each other as well as from other amino acids has been realized.
Inada Takefumi T Department of Anesthesiology, Kansai Medical University , Osaka , - - 2014
Abstract Propofol is an intravenous drug widely used for anesthesia and sedation. Previously, propofol was shown to inhibit cyclo-oxygenase (COX) and 5-lipoxygenase (5-LOX) activities. Because these enzyme-inhibiting effects have only been demonstrated in vitro, this study sought to ascertain whether similar effects might also be observed in vivo. In the ...
Kelley Nirvair S NS 1 Arizona College of Osteopathic Medicine, Midwestern University , Glendale, - - 2014
Abstract Background: Despite many known health benefits of n-3 polyunsaturated fatty acids (PUFA), there is a concern that their high degree of unsaturation may actually increase oxidative stress, lipid peroxidation (LPO), and chronic inflammatory diseases. Methods: In this review, we have analyzed results from published human studies regarding the effects ...
Liljeblad Jonathan F D JF School of Chemistry, Division of Surface and Corrosion Science, KTH Royal Institute of Technology, SE-100 44 Stockholm, Sweden. - - 2014
The morphology and molecular conformation of Langmuir-Blodgett deposited and floating monolayers of a selection of straight chain (eicosanoic acid, EA), iso (19-methyl eicosanoic acid, 19-MEA), and anteiso (18-methyl eicosanoic acid, 18-MEA) fatty acids have been investigated by Vibrational Sum Frequency Spectroscopy (VSFS), AFM imaging, and the Langmuir trough. While the ...
Chen Rui R State Key Laboratory of Biomembrane and Membrane Biotechnology, Tsinghua University-Peking University Joint Center for Life Sciences, School of Life Sciences, Tsinghua University, Beijing 100084, - - 2014
Organisms have evolved elaborate mechanisms to adjust intracellular nutrient levels in response to fluctuating availability of exogenous nutrients. During starvation, cells can enhance amino acid uptake and synthesis through the general amino acid control (GAAC) pathway, whereas nonessential cellular contents are recycled by autophagy. How these two pathways are coordinated ...
Luo Xu-Ying XY State Key Laboratory of Food Science and Technology, Nanchang Univ, Nanchang, 330047, China; Engineering Research Center of Biomass Conversion, Ministry of Education, Nanchang Univ, Nanchang, 330047, - - 2014
To identify inhibitors for lysinoalanine formation in preserved egg, sulfhydryl compounds (glutathione, L-cysteine), carbohydrates (sucrose, D-glucose, maltose), organic acids (L-ascorbic acid, citric acid, DL-malic acid, lactic acid), and sodium sulfite were individually added at different concentrations to a pickling solution to prepare preserved eggs. Lysinoalanine formation as an index of ...
Wakashima Takeshi T Hokkaido University, - - 2014
The sphingolipid metabolite sphingosine-1-phosphate (S1P) functions as a lipid mediator and as a key intermediate of the sole sphingolipid-to-glycerophospholipid metabolic pathway (S1P metabolic pathway). In this pathway, S1P is converted to palmitoyl-CoA through 4 reactions, then incorporated mainly into glycerophospholipids. Although most of the genes responsible for the S1P metabolic ...
Jang Eungyeong - - 2014
Artemisia capillaris (AC) has been recognized as one of the promising candidates for hepatoprotective, hypoglycemic, hypolipidemic, antiobesitic and anti-inflammatory therapeutic effectiveness. This study evaluated the inherent mechanism and anti-apoptotic activity of 30% ethanol extract of AC (AC extract) 100 mug/ml on free fatty acids (FFAs)-induced HepG2 cellular steatosis and lipoapoptosis. ...
Arunagiri Pandiyan P Department of Biochemistry and Biotechnology, Faculty of Science, Annamalai University, Annamalainagar, Tamil Nadu, 608 002, - - 2014
Manic episode in bipolar disorder (BD) was evaluated in the present study with supplementation of omega-3 fatty acids in combination with aripiprazole and lithium on methylphenidate (MPD)-induced manic mice model. Administration of MPD 5 mg/kg bw intraperitoneally (i.p.) caused increase in oxidative stress in mice brain. To retract this effect, supplementation ...
van Beilen J W A JW Molecular Biology & Microbial Food Safety, Swammerdam Institute for Life Sciences, University of Amsterdam, The - - 2014
Sorbic and acetic acid are amongst the most commonly used weak organic acid preservatives to improve the microbiological stability of foods. Both have a similar pKa value but sorbic acid is a far more potent preservative. Weak organic acids are most effective at low pH. Under these circumstances, they are ...
Dolce Vincenza V Department of Pharmacy, Health and Nutritional Sciences, University of Calabria, Arcavacata di Rende Cosenza, - - 2014
The citrate carrier (CiC), characteristic of animals, and the dicarboxylate-tricarboxylate carrier (DTC), characteristic of plants and protozoa, belong to the mitochondrial carrier protein family whose members are responsible for the exchange of metabolites, cofactors, and nucleotides between the cytoplasm and the mitochondrial matrix. Most of the functional data on these ...
Torres-Contreras Ana Mariel - - 2014
Potato tubers under wounding stress synthesize chlorogenic acid isomers, which are phenolic compounds that prevent chronic diseases. Phenolic compounds biosynthesis in plants requires aromatic amino acids that are produced from sugars. Therefore, in the present study, we hypothesized that the wound-induced accumulation of chlorogenic acid isomers in potatoes could be ...
Ruan Weimei W a Department of Chemistry , National University of Singapore , Singapore , - - 2014
The response surface methodology was used to optimise the extraction conditions of Ganoderma lucidum based on a Box-Behnken design. A quadratic model sufficiently simulated the response of ganoderic acid H with a determination coefficient (R(2)) of 0.98. The optimal condition for extracting triterpenoids was determined to be 100.00% ethanol at ...
Honcharenko Dmytro D Department of Biosciences and Nutrition, Karolinska Institutet, S-14183 Huddinge, Sweden. Roger.Stromberg@ki.se - - 2014
Peptide-like compounds containing an arginine have been shown to bind and stabilize the central helix of the Alzheimer's disease related amyloid-β peptide (Aβ) in an α-helical conformation, thereby delaying its aggregation into cytotoxic species. Here we study a novel Aβ targeting ligand AEDabDab containing the triamino acid, N(γ)-(2-aminoethyl)-2,4-diaminobutanoic (AEDab) acid. ...
Bartkiene Elena E Lithuanian University of Health Sciences, Tilzes str. 18, 47181, Kaunas, - - 2014
The ability of bacteriocin-like inhibitory substances (BLIS) producing lactic acid bacteria to degrade biogenic amines as well as to produce L(+) and D(-)-lactic acid during solid state fermentation (SSF) of lupine and soybean was investigated. In addition, the protein digestibility and formation of organic acids during SSF of legume were ...
Sun Xinxiao X State Key Laboratory of Chemical Resource Engineering, Beijing University of Chemical Technology, Beijing, China - - 2014
Non-oxidative decarboxylases belong to a unique enzyme family that does not require any cofactors. Here we report the characterization of a 2,3-dihydroxybenzoic acid (2,3-DHBA) decarboxylase (BDC) from Klebsiella pneumoniae and explore its application on the production of muconic acid. The enzyme properties were systematically studied, including the optimal temperature and ...
Fernández-Galilea Marta M Department of Nutrition, Food Science and Physiology, University of Navarra, Pamplona, - - 2014
α-Lipoic acid (α-LA) is a natural occurring antioxidant with beneficial effects on obesity. The aim of this study was to investigate the putative effects of α-LA on triglyceride accumulation and lipogenesis in subcutaneous adipocytes from overweight/obese subjects and to determine the potential mechanisms involved. Fully differentiated human subcutaneous adipocytes were ...
Zhao Mouming - - 2014
This study aimed to explore the potential of polished adlay, brown adlay, adlay bran and adlay hull to prevent and treat hyperuricemia. Brown adlay extract effectively decreased the serum uric acid levels of oxonate-induced hyperuricemic rats. Free and bound phenolic extracts from these materials contained significant amounts of phenolics, with ...
Malhotra Rajesh R Department of Chemistry, Guru Jambheshwar University of Science and Technology, Hisar, Haryana 125001, - - 2014
First regioselective ring opening of serine derived cyclic sulfamidate by hard nucleophiles like ArONa is developed, where β-elimination of serine sulfamidate ester by stronger nucleophiles is overcome by reversal of the electronic effect of the carboxylate anion. This method provides easy and direct access to a variety of N-Boc- and ...
Sethi Ankur A 1Rosalind Franklin University of Medicine and Science, North Chicago, IL; and 2Department of Medicine, Wright Center of Graduate Medical Education, Scranton, - - 2014
During last 2 decades, multiple studies have evaluated omega-3 polyunsaturated fatty acids (ω-3 PUFA) supplementation for cardiovascular prevention. The benefit found in previous studies was not demonstrated in more contemporary trials. We aimed to investigate effect of study characteristics, particularly concomitant statin therapy on results of randomized controlled trials. We ...
Li Jing J CAS Key Laboratory of Plant Germplasm Enhancement and Specialty Agriculture, Wuhan Botanical Garden, Chinese Academy of Sciences, Wuhan, 430074, China; University of Chinese Academy of Sciences, Beijing, 100049, - - 2014
Betulinic acid is a plant derived triterpenoid with beneficial effects for anti-tumor and anti-human immunodeficiency virus treatments. In Saccharomyces cerevisiae, we previously constructed the betulinic acid biosynthetic pathway, in which several enzymes function in a NADPH or oxygen-dependent manner. To seek whether the intracellular supply of the NADPH/oxygen of S. cerevisiae ...
Ke Haihua - - 2014
Efficient bis(phosphine)nickel catalyzed cross-couplings of diarylborinic acids with aryl chlorides, tosylates and sulfamates have been effected with an assistance of N-heterocyclic carbene (NHC) generated in situ from N,N'-dialkylimidazoliums, e.g. N-butyl-N'-methylimidazolium bromide ([Bmim]Br), in toluene using K3PO43H2O as base. In contrast to bis(NHC)nickel-catalyzed conventional Suzuki coupling of arylboronic acids, mono(NHC)bis(phosphine)nickel species ...
Snapp Anna R AR Department of Plant Sciences and Plant Pathology, Montana State University, Bozeman, MT, 59717-3150, - - 2014
Co-expression of a lesquerella fatty acid elongase and the castor fatty acid hydroxylase in camelina results in higher hydroxy fatty acid containing seeds with normal oil content and viability. Producing hydroxy fatty acids (HFA) in oilseed crops has been a long-standing goal to replace castor oil as a renewable source ...
Kapdi Anant R AR Department of Chemistry, Institute of Chemical Technology, Matunga, Mumbai-400019, - - 2014
Direct transmetallation between palladacyclic complexes and arylboronic acid occurs to give isolable transmetallation products. In THF, the reaction occurs <0.5 h. Prolonged reaction leads to the generation of a dinuclear Pd complex bearing bridging μ-hydroxo and μ-acetoxy ligands. Insight into precatalyst activation for Suzuki-Miyaura cross-couplings mediated by palladacycles has been ...
Arcan Iskender - - 2014
To develop edible films having controlled release properties for multiple bioactive compounds hydrophobicity and morphology of zein films were modified by blending zein with oleic (OLE) (C18:1)Δ9, linoleic (LIN) (C18:2)Δ9,12 or lauric (LAU) (C12) acids in presence of lecithin (LEC). The blend zein films showed 2 to 8.5 and 1.6 ...
Giedyk Maciej M Institute of Organic Chemistry PAS, Kasprzaka 44/52, 01-224 Warsaw (Poland), Fax: - - 2014
Specially designed B-ring-modified cobalamin derivatives were synthesized and tested as potential activators of soluble guanylyl cyclase (sGC). Herein, we disclose the influence of substituents at the c- and d-positions in hydrophilic and hydrophobic cobyrinic acid derivatives on their capacities to activate sGC. The presence of the amide group at c-/d-position ...
Tomaszewska Ludwika L Department of Biotechnology and Food Microbiology, Wrocław University of Environmental and Life Sciences, Chełmońskiego Str. 37/41, 51-630, Wrocław, - - 2014
Citric acid and erythritol biosynthesis from pure and crude glycerol by three acetate-negative mutants of Yarrowia lipolytica yeast was investigated in batch cultures in a wide pH range (3.0-6.5). Citric acid biosynthesis was the most effective at pH 5.0-5.5 in the case of Wratislavia 1.31 and Wratislavia AWG7. With a ...
Li Jianmei J Key Laboratory of Green Chemistry and Technology, Ministry of Education, College of Chemistry, Sichuan University, 29 Wangjiang Road, Chengdu, Sichuan, 610064 (PR China), Fax: - - 2014
Increased energy consumption and environmental concerns have driven efforts to produce chemicals from renewable biomass with high selectivity. Here, the selective conversion of cellulose in corncob residue, a process waste from the production of xylose, to levulinic acid was carried out using AlCl3 as catalyst and NaCl as promoter by ...
Nieto-Peñalver Carlos G CG PROIMI, CONICET (Planta Piloto de Procesos Industriales Microbiológicos), Av. Belgrano y Caseros, Tucumán T4001MVB, Argentina; Instituto de Microbiología, Facultad de Bioquímica, Química y Farmacia, Universidad Nacional de Tucumán, Tucumán, Argentina. Electronic address: - - 2014
Gluconic acid is produced in large quantities by the endophytic and diazotrophic bacterium Gluconacetobacter diazotrophicus Pal5. This organic acid derives from direct oxidation of glucose by a pyrroloquinoline-quinone-linked glucose dehydrogenase in this plant growth-promoting bacterium. In the present article, evidence is presented showing that gluconic acid is also responsible for ...
Jansson Therese - - 2014
The enzymatic hydrolysis of lactose to glucose and galactose gives rise to reactions that changes the chemistry and quality of ambient-stored lactose-hydrolyzed milk. The aim of the present study was to investigate and compare chemical changes in lactose-hydrolyzed and conventional UHT milk during a 9-month ambient storage period. Several complementary ...
Kim Moon Il MI Department of Chemical and Biomolecular Engineering (BK 21+ program), KAIST, Daejeon 305-701, Republic of Korea. - - 2014
A label-free colorimetric method to detect nucleic acids, which relies on target DNA induced shielding of the oxidase activity of CeO2 NPs, is developed. With this novel strategy, target nucleic acids can be identified within a few minutes and without the need for post-purification of PCR products.
Atanasova-Penichon Vessela V INRA, UR 1264 MycSA, 33882 Villenave d'Ornon, 71 Avenue Edouard Bourlaux, CS 20032, France ; - - 2014
Fusarium verticillioides infects maize ears, causing ear rot disease and contamination of grain with fumonisin mycotoxins. This contamination can be reduced by the presence of bioactive compounds in kernels that are able to inhibit fumonisin biosynthesis. To identify such compounds, we used kernels from a maize genotype with moderate susceptibility ...
Frankowski K M KM Department of Food, Bioprocessing and Nutrition Sciences, Southeast Dairy Foods Research Center, North Carolina State University, Raleigh - - 2014
Many food companies are trying to limit the amount of sodium in their products. Permeate, the liquid remaining after whey or milk is ultrafiltered, has been suggested as a salt substitute. The objective of this study was to determine the sensory and compositional properties of permeates and to determine if ...
Mykolayivna Lemishko Kateryna - - 2014
A significant acidity enhancement and changes on aromaticity were previously observed in squaric acid and its derivatives when beryllium bonds are present in those systems. In order to know if these changes on the chemical properties could be considered a general behavior of carboxylic acids upon complexation with beryllium compounds, ...
Areche Carlos C Departamento de Química, Facultad de Ciencias, Universidad de Chile, Casilla 653, Santiago, Chile. - - 2014
Four new mulinane-type diterpenoids besides the known compounds mulin-11,13-dien-20-oic acid, 13α-hydroxyazorellane, 13β-hydroxyazorellane, mulinolic acid, azorellanol, and mulin-11,13-dien-18-acetoxy-16,20-dioic acid were isolated from the Chilean plant Azorella trifurcata. One of the new metabolites isolated, 7α-acetoxy-9-epi-13β-hydroxymulinane, possesses a new trans-syn-trans arrangement in a tricyclic ring system not previously encountered in nature. Among the ...
Yang Xiao-Ming XM School of Food and Biological Engineering, Jiangsu University, Zhenjiang 212013, China. Electronic address: - - 2014
Ginkgolic acids are alkylsalicylic acid derivatives with a thermolabile carboxylic group from Ginkgo biloba L., and they exhibit anticancer activity. Their anticancer effects are closely associated with their thermal stability. In this study, the thermal decomposition of ginkgolic acids was analyzed at temperatures of 30, 50, 70 and 250ºC. The ...
Karwowska Ma Łgorzata ML Department of Meat Technology and Food Quality, University of Life Sciences in Lublin, ul. Skromna 8, 20-704, Lublin, - - 2014
The influence of the addition of mustard seed and acid whey on the stability of nitrite-free organic fermented sausage during 90 days of vacuum storage, by measuring primary and secondary products of lipid oxidation, the changes in the fatty acid composition and antioxidant capacity as well as water activity was ...
De Ruigh A A Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA; Department of Gastroenterology, Academic Medical Center Amsterdam, Amsterdam, The - - 2014
Recent studies have shown that Gaviscon Double Action Liquid (a combination alginate-antacid) administered post-prandially co-localises with the acid pocket, the 'reservoir' for post-prandial acid reflux. This study compared the effectiveness of Gaviscon Double Action Liquid to an equivalent strength antacid without alginate in controlling post-prandial acid reflux in GERD patients. ...
Herbst Annika A Institut für Anorganische Chemie und Strukturchemie, Heinrich-Heine-Universität Düsseldorf, Universitätsstrasse 1 , D-40225 Düsseldorf, - - 2014
Porous chromium(III) 2-nitro-, 2-amino-, and nonfunctionalized terephthalate (MIL-101Cr) metal organic frameworks are heterogeneous catalysts for diacetal formation from benzaldehyde and methanol (B-M reaction) as well as other aldehydes and alcohols. MIL-101Cr-NO2 obtained by direct reaction between CrO3 and 2-nitro-terephthalate showed the highest activity with 99% conversion in the B-M reaction ...
Pierce Barbara J BJ *Department of Biology, Sacred Heart University, 5151 Park Avenue, Fairfield, CT 06825, USA; Department of Natural Resources Science, University of Rhode Island, Coastal Institute in Kingston, 1161 Greenhouse Road, Kingston, RI 02881, USA - - 2014
Fatty-acid composition of fat stores affects exercise performance in a variety of vertebrates although few such studies focus on flying vertebrates such as migratory birds, which are exceptional exercisers. We first discuss the natural variation in quality of fat available in natural foods eaten by migratory birds and their behavioral ...
Lv Xiaomei X Department of Chemical and Biological Engineering, Zhejiang University, Hangzhou, 310027, PR - - 2014
To explore the capacity of isoprene production in Saccharomyces cerevisiae, a rational push-pull-restrain strategy was proposed to engineer the mevalonic acid (MVA) and acetyl-CoA pathways. The strategy can be decomposed into the up-regulation of precursor supply in the acetyl-CoA module and the MVA pathway (push-strategy), increase of the isoprene branch ...
Snelders Jeroen J Laboratory of Food Chemistry and Biochemistry & Leuven Food Science and Nutrition Research Centre (LFoRCe), KU Leuven , Kasteelpark Arenberg 20, B-3001 Leuven, - - 2014
The impact of arabinoxylanoligosaccharides (AXOS) with varying bound or free ferulic acid (FA) content on dough and bread properties was studied in view of their prebiotic and antioxidant properties. AXOS with an FA content of 0.1-1.7% caused an increase in dough firmness with increasing AXOS concentration. AXOS with a high ...
Mietkiewska Elzbieta E Alberta Innovates Phytola Centre, Department of Agricultural, Food and Nutritional Science, University of Alberta, 4-10 Agriculture/Forestry Centre, Edmonton, AB, T6G 2P5, - - 2014
Arabidopsis was engineered to produce 21.2 % punicic acid in the seed oil. Possible molecular factors limiting further accumulation of the conjugated fatty acid were investigated. Punicic acid (18:3Δ(9cis,11trans,13cis) ) is a conjugated linolenic acid isomer and is a main component of Punica granatum (pomegranate) seed oil. Medical studies have shown ...
Dollah Sarafhana S Department of Food Science, Faculty of Food Science and - - 2014
Blends (30:70, 50:50 and 70:30 w/w) of Moringa oleifera seed oil (MoO) with palm olein (PO), palm stearin (PS), palm kernel oil (PKO) and virgin coconut oil (VCO) were prepared. To determine the physicochemical properties of the blends, the iodine value (IV), saponication value (SV), fatty acid (FA) composition, triacylglycerol ...
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