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Song Li-Ying LY Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Datun Road, Chaoyang District, Beijing, 100101, China, - - 2013
Δ(8)-sphingolipid desaturase and Δ(6)-fatty acid desaturase share high protein sequence identity. Thus, it has been hypothesized that Δ(6)-fatty acid desaturase is derived from Δ(8)-sphingolipid desaturase; however, there is no direct proof. The substrate recognition regions of Δ(6)-fatty acid desaturase and Δ(8)-sphingolipid desaturase, which aid in understanding the evolution of these ...
Hall Daniel J DJ Department of Clinical Sciences, Tufts Cummings School of Veterinary Medicine, North Grafton, MA, - - 2013
n-3 fatty acids have some benefits in humans and dogs with cardiac disease, and plasma n-3 fatty acid concentrations have been shown to be decreased in dogs with congestive heart failure (CHF). However, there are no published studies reporting fatty acid concentrations in cats with cardiac disease. Therefore, the goal ...
Rudkowska Iwona I Institute of Nutrition and Functional Foods (INAF), Laval University, Quebec, Canada; Department of Endocrinology and Nephrology, CHU de Québec Research Center, Quebec, - - 2013
To determine if single nucleotide polymorphisms (SNPs) in stearoyl-CoA desaturase (SCD)-1 gene that encodes a key enzyme for fatty acid metabolism are associated with the response of cardiometabolic risk factors to n-3 PUFA supplementation. Two hundred and ten subjects completed a 2-week run-in period followed by 6-week supplementation with 5 ...
Kam Antony A Faculty of Pharmacy, University of Sydney, NSW 2006, - - 2013
The aim of this study was to investigate the protective effects of gallic acid, a common phenolic compound naturally present in food and nutraceuticals, on endothelial cell death and the mechanisms involved. Endothelial cell death was induced by the combination of homocysteine, adenosine and tumour necrosis factor (TNF) in human ...
Mohamed Riyaz R Department of Studies in Biochemistry, University of Mysore, Mysore, - - 2013
Lipoxygenases (LOX) are the key enzymes involved in the biosynthesis of leukotrienes and reactive oxygen species, which are implicated in pathophysiology of inflammatory disorders. This study was conducted to evaluate the inhibitory effect of water-soluble antioxidant ascorbic acid and its lipophilic derivative, ascorbic acid 6-palmitate (Vcpal) on polymorphonuclear lymphocyte 5-LOX ...
Nguyen Chi C 1] Departments of Molecular Biology and Biochemistry, Chemistry, and Pharmaceutical Sciences, University of California, Irvine, California 92697, USA - - 2013
Acyl carrier protein (ACP) transports the growing fatty acid chain between enzymatic domains of fatty acid synthase (FAS) during biosynthesis. Because FAS enzymes operate on ACP-bound acyl groups, ACP must stabilize and transport the growing lipid chain. ACPs have a central role in transporting starting materials and intermediates throughout the ...
Li Chuang-Jun CJ State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China. Electronic address: - - 2013
Three novel xanthonolignoid C-glycosides, glomexanthones A-C, with a trans-dihydrobenzofuran on B ring and a 2-hydroxymethyl-5-hydroxyl-2-pentenoic acid moiety in the sugar chain were isolated from an ethanol extract of Polygala glomerata. Their structures and absolute configurations were characterized by extensive NMR, MS, and CD spectroscopic studies. Screening results indicated that compounds ...
Jiang Lilong L School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210046, China; School of Pharmacy, Hainan Medical University, Haikou 571101, - - 2013
Factor Xa (FXa) plays an important role in blood coagulation. This study investigated glycyrrhetinic acid, a small molecule derived from Chinese herbs, and whether it has a direct inhibitory effect on FXa to display its anticoagulant activity. Enzyme activities of FXa, plasmin, trypsin and thrombin, inhibition of FXa enzyme kinetics ...
Shimotori Yasutaka Y Department of Biotechnology and Environmental Chemistry, Kitami Institute of Technology, 165 Koen-cho, Kitami, Hokkaido 090-8507, Japan. Electronic address: - - 2013
Various hydroxycinnamoyl β-d-xylopyranosides were efficiently prepared from 2,3,4-tri-O-acetyl-α-d-xylopyranosyl bromide (TAXB) with amine by amine-promoted glycosylation. The resulted acetylated hydroxycinnamoyl β-d-xylopyranosides with acetoxy groups at C-2, C-3, and C-4 were regioselectively deacetylated at C-4 position with Novozym 435. Antioxidant activities of free hydroxycinnamic acids and the respective β-d-xylopyranosides were evaluated by ...
Rana Muhit M Department of Chemistry and RNA Institute, University at Albany, SUNY, 1400 Washington Avenue, Albany, New York 12222, USA. - - 2013
Graphene oxide has gained significant attention due to its exceptional physical properties at biological interfaces. It has extraordinary quenching, fast adsorption and desorption properties that are suitable for detection of molecular interactions in nucleic acids. Here we studied the interaction between locked nucleic acid (LNA) modified oligonucleotides and its complementary ...
Sangthong Winyoo W Laboratory for Computational and Applied Chemistry, Department of Chemistry, Faculty of Science and Center of Nanotechnology, Kasetsart University Research and Development Institute, Kasetsart University, Bangkok 10900 (Thailand), Fax: (+66) 2-562-5555; NANOTEC Center for Nanoscale Materials for Green Nanotechnology, Kasetsart University, Bangkok 10900 (Thailand); Center for Advanced Studies in Nanotechnology and its Applications in Chemical, Food, and Agricultural Industries, Kasetsart University, Bangkok 10900 - - 2013
Finding novel catalysts for the direct conversion of CO2 to fuels and chemicals is a primary goal in energy and environmental research. In this work, density functional theory (DFT) is used to study possible reaction mechanisms for the conversion of CO2 and C2 H6 to propanoic acid over a gold-exchanged ...
Leite Carla A - - 2013
Lysine plays an important role in Streptomyces clavuligerus metabolism; it takes part in its catabolism, via cadaverine, and in its secondary metabolism, in which lysine is converted via 1-piperideine-6-carboxylate to alpha-aminoadipic acid, a beta-lactam antibiotic precursor. The role of lysine as an enhancer of cephamycin C production, when added to ...
Wang Yanlong Y State Key Laboratory of Structural Chemistry, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, Fujian, Fuzhou 350002 (P.R. China), Fax: (+86) 591-8371-4946; Graduate School of the Chinese Academy of Sciences, Beijing 100039 (P.R. - - 2014
The microporous metal-organic framework (MMOF) Zn4 O(L1)2 ⋅9 DMF⋅9 H2 O (1-H) and its functionalized derivatives Zn4 O(L1-CH3 )2 ⋅9 DMF⋅9 H2 O (2-CH3 ) and Zn4 O(L1-Cl)2 ⋅9 DMF⋅9 H2 O (3-Cl) have been synthesized and characterized (H3 L1=4-[N,N-bis(4-methylbenzoic acid)amino]benzoic acid, H3 L1-CH3 =4-[N,N-bis(4-methylbenzoic acid)amino]-2-methylbenzoic acid, H3 L1-Cl=4-[N,N-bis(4-methylbenzoic acid)amino]-2-chlorobenzoic acid). Single-crystal X-ray diffraction analyses confirmed ...
Takei Toshiki - - 2013
Although the catalytic triad of glutathione peroxidase (GPx) has been well recognized, there was little evidence for the relevance of the interactions among the triad amino acid residues, i.e., selenocysteine (U), glutamine (Q), and tryptophan (W), to the GPx antioxidative functions. Using a designed selenopeptide having an amino acid sequence ...
Saprygina Natalya N - - 2013
The kinetics of the photooxidation of aromatic amino acids histidine (His), tyrosine (Tyr), and tryptophan (Trp) by 3,3',4,4'-benzophenone tetracarboxylic acid (TCBP) has been investigated in aqueous solutions using time-resolved laser flash photolysis and time-resolved chemically induced dynamic nuclear polarization. The pH dependence of quenching rate constants is measured within a ...
Nakagawa Fumiyuki F Department of Medicine, Shiga University of Medical Science, Seta Tsukinowa-Cho, Otsu, Shiga 520-2192, Japan.; Osaka Laboratory, JCL Bioassay Corporation, 5-16-26, Minamisuita, Suita-shi, Osaka 564-0043, - - 2013
It has recently been reported that expression of heme oxygenase-1 (HO-1) plays a protective role against many diseases. Furthermore, n-3 polyunsaturated fatty acids (PUFAs) were shown to induce HO-1 expression in several cells in vitro, and in a few cases also in vivo. However, very few reports have demonstrated that ...
Borges Anabela A a LEPABE, Faculty of Engineering, Department of Chemical Engineering , University of Porto , Porto , - - 2013
Quorum sensing (QS) is an important regulatory mechanism in biofilm formation and differentiation. Interference with QS can affect biofilm development and antimicrobial susceptibility. This study evaluates the potential of selected phytochemical products to inhibit QS. Three isothiocyanates (allylisothiocyanate - AITC, benzylisothiocyanate - BITC and 2-phenylethylisothiocyanate - PEITC) and six phenolic ...
Chen Wen-Hsing WH Department of Environmental Engineering, National Ilan University, Yilan, 260, Taiwan, - - 2013
This study evaluated a cost-effective approach for the conversion of rice straw into fermentable sugars. The composition of rice straw pretreated with 1 % sulfuric acid or 1 % sodium hydroxide solution was compared to rice straw with no chemical pretreatment. Enzymatic saccharification experiments on non-pretreated rice straw (NPRS), pretreated rice straw ...
Liu Zhen Z State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, , Kunming 650223, China, University of the Chinese Academy of Sciences, , Beijing 100039, China, Key Laboratory of Adaptation and Evolution of Plateau Biota, Northwest Institute of Plateau Biology, Chinese Academy of Sciences, , Xining 810008, China, Centre for Biodiversity and Conservation Biology, Royal Ontario Museum, , Toronto, Canada , M5S - - 2014
Hibernating mammals need to be insensitive to acid in order to cope with conditions of high CO2; however, the molecular basis of acid tolerance remains largely unknown. The African naked mole-rat (Heterocephalus glaber) and hibernating mammals share similar environments and physiological features. In the naked mole-rat, acid insensitivity has been ...
Augustine Alicia H AH Department of Public Health Sciences, University of Rochester Medical Center, Rochester, NY, United - - 2013
The effects of dietary fatty acid supplementation on lipoprotein fatty acid composition have rarely been described. Sixty-one overweight and obese adults with dyslipidemia and insulin resistance were randomized to placebo, 2g/day extended-release nicotinic acid (ERN), 4g/day prescription omega-3 fatty acid ethyl ester (P-OM3), or combination therapy for 16 weeks. Lipoprotein ...
Flock Michael R MR Department of Nutritional Sciences, The Pennsylvania State University, Pennsylvania, - - 2013
The purpose of this review is to discuss macronutrient replacement options for saturated fatty acids (SFAs) to optimize cardiovascular disease (CVD) risk reduction. Dietary recommendations advise decreasing SFAs. There is convincing evidence that replacing SFAs with unsaturated fat, both omega-6 and omega-3 polyunsaturated fatty acids, reduces CVD risk. Monounsaturated fatty ...
Wang Jie J The Key Laboratory of Food Colloids and Biotechnology, Ministry of Education, School of Chemical and Material Engineering, Jiangnan University, Wuxi 214122, PR - - 2013
The copolymer of poly(l-malic acid-co-d,l-lactic acid) (PML) was synthesized through a direct polycondensation of l-malic acid (MA) and d,l-lactic acid (LA). Then, a new polyelectrolyte complex (PEC) based on the complexation between the copolymer (PML) and chitosan (CS) was prepared. The PEC formed stable nano particles in aqueous solutions with ...
Demiralay Ebru Çubuk EC Department of Chemistry, Faculty of Science and Literature, Süleyman Demirel University, 32260 Isparta, Turkey. Electronic address: - - 2013
In this work, thermodynamic acidity constants (pssKa) of methicillin, oxacillin, nafcillin, cloxacilin, dicloxacillin were determined with reverse phase liquid chromatographic method (RPLC) by taking into account the effect of the activity coefficients in hydro-organic water-acetonitrile binary mixtures. From these values, thermodynamic aqueous acidity constants of these drugs were calculated by ...
Wang Caixia C National Key Laboratory of Biochemical Engineering, Institute of Process Engineering, Chinese Academy of Sciences, Beijing 100190, PR China; Graduate University of Chinese Academy of Sciences, Beijing 100049, PR - - 2013
Succinic acid was produced in a novel membrane-based fermentation and separation integrated system. With this integrated system, product inhibition was alleviated by removing acids and replenishing fresh broth. High cell density maintain for a longer time from 75 to 130h and succinic acid concentration increased from 53 to 73g/L. In ...
Martí-Centelles Vicente - - 2013
A family of pseudopeptidic macrocycles containing non-natural amino acids has been synthesized. The macrocyclization reaction was studied experimentally and computationally, demonstrating the key role of the amino acid side chain and the catalytic bromide anion. The anion acts as a template assisting the folding of the open-chain precursor in a ...
Macdonald Jacob P JP Department of Chemistry, University of California, One Shields Avenue, Davis, California 95616, USA. - - 2013
A Lewis acid-catalyzed stereoselective [3+2] annulation of crotylsilanes with iminooxindoles is reported to access 2,3'-pyrrolidinyl spirooxindoles with four stereocenters. The addition of NaBArF significantly enhances reactivity, allowing either metal salts or acidic clay to be effective catalysts for the stereoselective reaction.
Ito Junitsu J Department of Biochemistry and Molecular Biology, Yamagata University School of Medicine, Yamagata, - - 2013
Aldehyde reductase (AKR1A), a member of the aldo-keto reductase superfamily, is highly expressed in the liver and is involved in both the detoxification of carbonyl compounds and ascorbic acid biosynthesis. By comparison with wild-type mice, Akr1a-knockout (Akr1a(-/-)) mice and human Akrla-transgenic (Akr1a(tg/+)) mice experience different anesthetic actions from pentobarbital-prolonged in ...
Nam Kyong-Hee KH Bio-Evaluation Center, KRIBB, 30 Yeongudanji-ro, Ochang-eup, Cheongwon, 363-883, Republic of - - 2014
Comparing well-watered versus deficit conditions, we evaluated the chemical composition of grains harvested from wild-type (WT) and drought-tolerant, transgenic rice (Oryza sativa L.). The latter had been developed by inserting AtCYP78A7, which encodes a cytochrome P450 protein. Two transgenic Lines, '10B-5' and '18A-4', and the 'Hwayoung' WT were grown under ...
Wang K K Department of Physiology, School of Medical Sciences, University of New South Wales, Sydney, New South Wales, - - 2013
Dietary iron supplementation is associated with gastrointestinal (GI) side effects including vomiting, nausea, and diarrhea. Although inorganic iron in high concentrations may be damaging to the intestinal mucosa, we hypothesize that there are physiological effects on the GI tract that occur at concentrations achieved by supplementation. Thus, our aim was ...
Lee Young-Chul YC Department of Biological Engineering, College of Engineering, Inha University, Incheon 402-751, Republic of - - 2013
Biofuels (biodiesel) production from oleaginous microalgae has been intensively studied for its practical applications within the microalgae-based biorefinement process. For scaled-up cultivation of microalgae in open ponds or, for further cost reduction, using wastewater, humic acids present in water-treatment systems can positively and significantly affect the harvesting of microalgae biomass. ...
Yu Yuanshan Y Sericulture and Agri-Food Research Institute, Guangdong Academy of Agricultural Sciences, Guangzhou 510610, PR - - 2014
In this study, the effects of ultra-high pressure homogenisation (UHPH) processing at 200MPa for 1-3 successive passes (inlet temperatures at 4°C) were compared with pasteurisation (95°C, 1min) processing on phenolic compounds, antioxidant capacity (ORAC value) and anti-glucosidase of mulberry juice. Compared with thermal pasteurisation processing, the more reductions in the ...
Mullooly Niamh N 1 University College Dublin, - - 2013
Recent metabolic profiling studies have identified a correlation between branched-chain amino acid levels, insulin resistance associated with pre-diabetes and susceptibility to type 2 diabetes. Glucose and lipids in chronic excess have been reported to induce toxic effects in pancreatic beta cells but the effect of elevated amino acid concentrations on ...
Wan P-J PJ State Key Laboratory of Rice Biology, China National Rice Research Institute, Hangzhou, China; Education Ministry Key Laboratory of Integrated Management of Crop Diseases and Pests, College of Plant Protection, Nanjing Agricultural University, Nanjing, - - 2013
Nilaparvata lugens is a serious phloem-feeding pest of rice throughout Asia. Rice phloem sap can meet its nutrition requirement for sugars but not for some essential amino acids such as isoleucine, leucine, methionine, phenylalanine, tryptophan, lysine, arginine and histidine. N. lugens harbours yeast-like symbionts in mycetocytes formed by abdominal fat body cells. ...
Flanagan John J Naturex SA, Site d'Agroparc BP 1218, 84911, Avignon Cedex 9, - - 2013
The beneficial health effects of chlorogenic acids (CGAs), major components of coffee beans, are well known and have been attributed to multiple mechanisms of action. However, the lipolytic activity of CGAs does not appear to have been reported. We studied the effects of varying concentrations of Svetol®, a decaffeinated green ...
Kim Hye Yoom HY Hanbang Body-fluid Research Center & Professional Graduate School of Oriental Medicine, Wonkwang University, Iksan, Jeonbuk 570-749, Republic of - - 2013
Ursolic acid has recently been reported to increase both atrial natriuretic peptide (ANP) secretion and mechanical dynamics in rabbit atria. The present study was designed to clarify the regulatory effects of ursolic acid on the β-adrenergic or muscarinic receptor-mediated changes in ANP secretory and contractile function allowing measurement of atrial ...
Kim Daniel Seung - - 2013
Paraoxonase 1 (PON1) is a cardioprotective, HDL-associated glycoprotein enzyme with broad substrate specificity. Our previous work found associations between dietary cholesterol and vitamin C with PON1 activity. The goal of this study was to determine the effect of specific dietary fatty acid (DFA) intake on PON1 activity. 1,548 participants with ...
Moreno-Pérez Antonio Javier - - 2013
The substrate specificity of the acyl-acyl carrier protein (ACP) thioesterases significantly determines the type of fatty acids that are exported from plastids. Thus, designing acyl-ACP thioesterases with different substrate specificities or kinetic properties would be of interest for plant lipid biotechnology to produce oils enriched in specialty fatty acids. In ...
Kampe Kapil K 1University Hospital - - 2013
Type 2 diabetes is characterized by dyslipidemia with elevated free fatty acids (FFAs). Loss of podocytes is a hallmark of diabetic nephropathy, and podocytes are susceptible to saturated FFAs, which induce endoplasmic reticulum (ER) stress and podocyte death. Genome wide association studies indicate that expression of acetyl-CoA carboxylase (ACC) 2, ...
Radhakrishnakartha Harikrishnan H Department of Biochemistry, University of Kerala, Thiruvananthapuram-695 581, - - 2013
The impact of ascorbic acid supplementation against ethanol induced Leydig cell toxicity was studied in guinea pigs. Male guinea pigs were exposed to ethanol (4g/ kg b.wt.) for 90 days. After 90 days, ethanol administration was completely stopped and animals in the ethanol group were divided into abstention group and ...
Lee Ji-Hyun JH Department of Endocrinology and Metabolism, Ajou University School of Medicine, Suwon, Kyunggi-do 442-749, Republic of - - 2013
This work was initiated to determine whether toxicity generated through inhibition of mitochondrial fuel metabolism is similar to high glucose/palmitate (HG/PA)-induced glucolipotoxicity. Influx of glucose and free fatty acids into the tricarboxylic acid (TCA) cycle was inhibited by treatment with the pyruvate carboxylase (PC) inhibitor phenylacetic acid (PAA) and carnitine ...
Oshiro Noriko N Massachusetts General Hospital, United - - 2013
Activation of mTOR complex 1 by amino acids is mediated in part by the Rag GTPases, which bind the raptor subunit of mTORC1 in an amino acid stimulated manner and promote mTORC1 interaction with Rheb-GTP, the immediate activator. Herein we examine whether the ability of amino acids to regulate mTORC1 ...
Luo Zhibing - - 2013
For most organisms, carbon and nitrogen uptake are essential for growth, development, and where applicable, pathogenesis. The role of the carbon catabolite repressor transcription factor homolog, BbcreA, in the entomopathogenic fungus Beauveria bassiana was investigated. Deletion of BbcreA resulted in pleiotropic effects including nutrient toxicity leading to a novel cell ...
Nostro Antonia - - 2013
Staphylococcal growth and biofilm formation in culture medium where pH was lowered with weak organic (acetic and lactic) or strong inorganic (hydrochloric) acids were studied. The effects were evaluated by biomass measurements, cell-surface hydrophobicity, scanning electron microscopy (SEM), and confocal laser scanning microscopy (CLSM). The results demonstrated that the inhibition ...
Tao Rongsheng - - 2013
L-2-Aminobutyric acid (L-ABA) is an unnatural amino acid that is a key intermediate for the synthesis of several important drugs. It can be produced by transaminase or dehydrogenase from α-ketobutyric acid, which can be synthesized enzymatically from the bulk amino acid, L-threonine. Deamination of L-threonine followed by a hydrogenation reaction ...
Zhao Yang - - 2013
One of the two branches of the α-linolenic acid metabolism pathway is catalyzed by OPRI, and the other is involved in JA synthesis. The former is known to be active in the response to salinity tolerance in wheat (Triticum aestivum), but the participation of the latter in this response has ...
Kumar Pushpender P Department of Pharmacology, I.S.F. College of Pharmacy, Ferozepur Road, Ghal Kalan, Moga 142001, Punjab, - - 2013
Huntington's disease is an autosomal dominant, progressive, and fatal neurodegenerative disease characterized by motor and non-motor symptoms. Systemic administration of 3-nitropropionic acid, a complex II inhibitor of the electron transport chain induces selective striatal lesions in rodents. Neurosteroids are synthesized in central nervous system, able to modulate GABAA receptor function ...
Tamaru Shun-Ichi - - 2013
Amphoteric β-1,3-glucans possessing both amino groups and carboxylic acid groups on the C6 positions of glucose units were designed and synthesized from naturally produced curdlan. The amphoteric polysaccharides showed the isoelectric point and the pH responsive interconversion between the original triple helix and single-stranded random structures. Since the pH dependences ...
Remling N - - 2013
The aim of this study was to determine the influence of fumaric acid (FA) on ruminal fermentation and its effects on the acid-base balance of seven ruminally and duodenally fistulated multiparous German Holstein cows. The experiment was conducted in a change-over design with three periods in which the animals were ...
Ortega-Heras Miriam - - 2013
The aim of this study was to determine the effect of three factors directly related to the amino acid content of grapes and their interaction. These three factors were vintage, maturity degree and irrigation. The amino acid evolution was also assessed during the winemaking along with the effect of maturity ...
Kakiuchi Hitoshi H Laboratory of Physiology II, Department of Veterinary Medicine, School of Veterinary Medicine, Azabu University, 1-17-71 Fuchinobe, Chuo-ku, Sagamihara, Kanagawa 252-5201, - - 2013
Tranexamic acid suppresses post-partum haemorrhage and idiopathic menorrhagia through its anti-fibrinolytic action. Although it is clinically useful, it is associated with high risks of side effects such as emesis. Understanding the mechanisms underlying tranexamic acid-induced emesis is very important to explore appropriate anti-emetic drugs for the prevention and/or suppression of ...
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