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Chen J - - 2014
Enalapril maleate (EM) is unstable in poorly designed tablet formulations. To improve the stability of EM, the degradation mechanism should be elucidated. In this study, we found that several commonly used excipients promoted the degradants of EM, particularly a diketopiperazine derivative (DKP). We propose two degradation pathways in which both ...
Dibrova Daria V - - 2014
While certain archaea appear to synthesize and/or metabolize fatty acids, the respective pathways still remain obscure. By analysing the genomic distribution of the key lipid-related enzymes, we were able to identify the likely components of the archaeal pathway of fatty acid metabolism, namely, a combination of the enzymes of bacterial-type ...
Tyurenkov I N IN Volgograd State Medical University, Volgograd, - - 2014
In contrast to L-glutamic acid (200 mg/kg), β-phenylglutamic acid hydrochloride (26 mg/kg) produces no anticonvulsant effects during generalized convulsions induced by "maximum electric shock". However, β-phenylglutamic acid hydrochloride was more potent than L-glutamic acid in increasing survival rate, promoting recovery of spontaneous motor activity, and maintainance locomotor and exploratory activity ...
Wójcik Cezary - - 2014
We have evaluated the effects of three different omega-3 polyunsaturated fatty acids (ω-3 PUFAs) – docosahexaenoic acid (DHA), eicosapentaenoic acid (EPA) and docosapentaenoic acid (DPA) on fat accumulation and expression of adipogenic and inflammatory markers using both 3T3-L1 pre-adipocytes and differentiated 3T3-L1 adipocytes. Our results indicate that ω-3 PUFAs induce ...
Stojanović Gordana S - - 2014
Three lichen secondary metabolites atranorin (1), evernic acid (2), and usnic acid (3), were evaluated for their in vitro clastogenic and antiproliferative effects on human lymphocytes using the cytochalasin-B blocked micronucleus (CBMN) assay at concentrations of 2 microg/mL, 4 microg/mL and 6 microg/mL of final culture solution. The frequency of ...
Honda Shinichi S a Frontier Biochemical & Medical Research Laboratories, Kaneka Corporation , Takasago , - - 2014
We applied Chrysanthemum flower oil (CFO) to a hyperuricemia model by feeding rats a hyperuricemia-inducing diet (HID) and investigated its effect on serum uric acid (SUA) levels and its mode of action. CFO is the oily fraction that contains polyphenols derived from chrysanthemum flowers. Oral administration of CFO to HID-fed ...
Alvarez-Munoz Diana - - 2014
Alcohol polyethoxylate (AEO) surfactants are widely used in household and industrial products , but the health effects arising from short term exposures to sublethal concentrations are unknown. A metabolomics approach was used to investigate the biotransformation and effects of exposure to sublethal concentrations of hexaethylene glycol monododecylether (C12EO6) in juvenile ...
Herbert Samantha L SL Behavior and Metabolism Laboratory, Champalimaud Neuroscience Programme, Champalimaud Centre for the Unknown, 1400-038 Lisbon, - - 2014
Animals need to ingest a full set of essential amino acids through their diet. A new study in Drosophila larvae describes how activation of the kinase GCN2 in three dopaminergic neurons mediates the rejection of amino-acid-imbalanced food.
Usami Yuki Y Department of Chemistry and Biological Science, College of Science and Engineering, Aoyama Gakuin University, Sagamihara, - - 2014
Leucine is a major amino acid in nutrients and proteins and is also an important precursor of higher alcohols during brewing. In Saccharomyces cerevisiae, leucine uptake is mediated by multiple amino acid permeases, including the high-affinity leucine permease Bap2. Although BAP2 transcription has been extensively analyzed, the mechanisms by which ...
Fonseca María Isabel MI Laboratorio de Biotecnología Molecular, Módulo de Bioquímica y Farmacia, Facultad de Ciencias Exactas Químicas y Naturales, UNaM, Av. Mariano Moreno 1375 (3300), Posadas, Misiones, Argentina, - - 2014
Nine aromatic compounds (caffeic acid, syringaldehyde, vanillic acid, guaiacol, vanillin, sinapic acid, syringol, syringic acid and ferulic acid) and four metallic compounds (CuSO4, AgNO3, MnSO4, and CaCl2) were tested for their ability to increase laccase (Lac) activity in the ligninolytic basidiomycete Phlebia brevispora BAFC 633. The addition of syringaldehyde, syringol, ...
Teixeira Januana S JS Department of Agricultural, Food and Nutritional Science, University of Alberta, 4-10 Ag/For, Edmonton, AB, Canada T6G - - 2014
This study aimed to determine whether glutamine deamidation improves acid resistance of Lactobacillus reuteri, and to assess whether arginine, glutamine, and glutamate-mediated acid resistance are redundant or complementary mechanisms of acid resistance. Three putative glutaminase genes, gls1, gls2, and gls3, were identified in L. reuteri 100-23. All three genes were expressed ...
Zhang Jun-Xia JX Department of Endocrinology and Metabolism, Southwest Hospital, Third Military Medical University, No. 30, Gaotanyanzheng Street, Shapingba District, Chongqing, 400038, - - 2014
Hyperuricemia is recently reported involving in various obesity-related cardiovascular disorders, especially hypertension. However, the underlying mechanisms are not completely understood. In the present study, we investigated whether uric acid upregulates renin-angiotensin system (RAS) expression in adipocytes. We also examined whether RAS activation plays a role in uric acid-induced oxidative stress ...
Li Weiguang W School of Municipal and Environmental Engineering, Harbin Institute of Technology, 73 Huanghe Road, Harbin, 150090, People's Republic of China, - - 2014
The effects of the organic loading rate (OLR) on the performance and the granular sludge characteristics of an expanded granular sludge bed (EGSB) reactor used for treating real traditional Chinese medicine (TCM) wastewater were investigated. Over 90 % of the COD removal by the EGSB reactor was observed at the OLRs ...
Karau Andreas A Evonik Industries AG, Business Line Health Care, Rodenbacher Chaussee 4, 63457, Hanau-Wolfgang, Germany, - - 2014
: Amino acids are key components of human and animal nutrition, both as part of a protein-containing diet, and as supplemented individual products. In the last 10 years there has been a marked move away from the extraction of amino acids from natural products, which has been replaced by efficient fermentation ...
Thalluri Kishore - - 2014
Ethyl 2-cyano-2-(4-nitrophenylsulfonyloxyimino)acetate (4-NBsOXY) mediated Lossen rearrangement and its application for the synthesis of ureas is demonstrated. Required hydroxamic acids for the Lossen rearrangement were synthesized from carboxylic acids using the same reagent. Finally, reaction of an amine with the produced isocyanate resulted in urea. Good yields without racemization were achieved ...
Sugiyama Minetaka M Department of Biotechnology, Graduate School of Engineering, Osaka University 2-1 Yamadaoka, Suita, Osaka 565-0871, - - 2014
Improvement of lactic acid resistance of the yeast Saccharomyces cerevisiae is important for the application of this yeast in industrial production of lactic acid from renewable resources. However, we still do not know the precise mechanisms of the lactic acid adaptation response in yeast and consequently lack effective approaches for ...
Wang Pei-Hui PH MOE Key Laboratory of Aquatic Product Safety / State Key Laboratory of Biocontrol, School of Life Sciences. Electronic address: - - 2014
Nucleic acids derived from viral pathogens are typical pathogen associated molecular patterns (PAMPs). In mammals, the recognition of viral nucleic acids by pattern recognition receptors (PRRs), which include Toll-like receptors (TLRs) and retinoic acid-inducible gene (RIG)-I-like receptors (RLRs), induces the release of inflammatory cytokines and type I interferons (IFNs) through ...
Duarte Susan Hartwig SH Laboratory of Bioprocess Engineering, Faculty of Food Engineering - UNICAMP, Campinas, Brazil. Electronic address: - - 2014
The quality of biodiesel from lipids produced by the yeast Candida sp. LEB-M3 was predicted, by the use of mathematical models for parameters that specify quality as a function of the fatty acid profile. The lipid production was studied according to the experimental design methodology, for different cultivation conditions for ...
Ma Linlin L From the Department of Physiology and Membrane Biology (L.M., B.H.L., J.Z.) and Division of Cardiovascular Medicine (H.C., S.S.), University of California School of Medicine, Davis; Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan Province, China (R.M, A.C., Y.J., L.X.); and Institute for Molecular Bioscience, University of Queensland, St Lucia, Queensland, Australia - - 2014
Nicotinic acid (also known as niacin or vitamin B3), widely used to treat dyslipidemias, represents an effective and safe means to reduce the risk of mortality from cardiovascular disease. Nonetheless, a substantial fraction of patients discontinue treatment because of a strong side effect of cutaneous vasodilation, commonly termed flushing. In ...
El Azzouny Mahmoud A MA University of Michigan, United - - 2014
Acute fatty acid (FA) exposure potentiates GSIS in β-cells through metabolic and receptor mediated effects. We assessed the effect of fatty acids on the dynamics of the metabolome in INS-1 cells following exposure to U-[13C]glucose to assess flux through metabolic pathways. Metabolite profiling showed a fatty acid-induced increase in long ...
Yu Hai-Ning HN College of Pharmaceutical Science, Zhejiang University of Technology, Hangzhou, - - 2014
Many studies show that fish oil with high content of n-3 polyunsaturated fatty acids (PUFAs) plays an important role in human health and disease. But the effects of fish oil with high content of PUFAs on gut microbiota, which are also known play a significant role in several human diseases, ...
Michas George G Unit of Human Nutrition, Department of Food Science and Human Nutrition, Agricultural University of Athens, Iera Odos 75, Athens 11855, - - 2014
Dietary fatty acids play significant roles in the cause and prevention of cardiovascular disease (CVD). Trans fatty acids from partially hydrogenated vegetable oils have well-established adverse effects and should be eliminated from the human diet. CVD risk can be modestly reduced by decreasing saturated fatty acids (SFA) and replacing it ...
Wang Kun K School of Environmental Science and Engineering, Zhejiang Gongshang University, Hangzhou 310012, China; Zhejiang Provincial Key Laboratory of Solid Waste Treatment and Recycling, Hangzhou 310012, - - 2014
Food waste anaerobic fermentation was carried out under acidic conditions using inocula based on aerobic activated sludge (Inoculum AE) or anaerobic activated sludge (Inoculum AN) for volatile fatty acids (VFAs) production. The results showed that food waste hydrolysis increased obviously when Inoculum AN was used relative to Inoculum AE at ...
Kemppainen Robert J RJ Department of Anatomy, Physiology, and Pharmacology, College of Veterinary Medicine, Auburn University, Auburn, - - 2014
A commercial immunoradiometric assay kit designed for the measurement of endogenous adrenocorticotropin (ACTH) concentrations in human plasma does not detect the molecule in plasma samples from cats. It was hypothesized that the inability of the assay to detect the molecule was related to variation(s) in the amino acid sequence of ...
Li Suhua - - 2014
Mono-selective γ-C-H olefination and carbonylation of aliphatic acids has been accomplished by using a combination of a quinoline-based ligand and a weakly coordinating amide directing group. The reaction provides a new route for constructing richly functionalized all-carbon quaternary carbon centers at the beta-position of aliphatic acids.
Hu Shengjun S Department of Food, Agricultural, and Biological Engineering, The Ohio State University/Ohio Agricultural Research and Development Center, 1680 Madison Ave, Wooster, OH 44691-4096, - - 2014
A two-step sequential biomass liquefaction process was developed to produce bio-based polyols and polyurethane (PU) foams using crude glycerol as a liquefaction solvent. The first step, acid-catalyzed liquefaction, was highly effective in liquefying biomass, while the second step, base-catalyzed liquefaction, featured extensive condensation reactions. By using the developed two-step liquefaction ...
Wang Haiwei H Division of Livestock Infectious Diseases, State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, No. 427 Maduan Street, Harbin, 150001, - - 2014
Infection by foot-and-mouth disease virus (FMDV) is triggered by the acidic pH in endosomes after virus uptake by receptor-mediated endocytosis. However, dissociation of the FMDV 146S particle in mildly acidic conditions renders inactivated foot-and-mouth disease (FMD) vaccines much less effective. Type Asia1 FMDV mutants with increased resistance to acid inactivation ...
Zwane Eunice N EN Department of Microbiology, Stellenbosch University, Private Bag X1, Matieland, 7602, South - - 2014
The production of ferulic acid esterase involved in the release of ferulic acid side groups from xylan was investigated in strains of Aspergillus tubingensis, Aspergillus carneus, Aspergillus niger and Rhizopus oryzae. The highest activity on triticale bran as sole carbon source was observed with the A. tubingensis T8.4 strain, which ...
Yamada Hidetoshi H Iwate Biotechnology Research Center, - - 2014
Peroxisome proliferator-activated receptors (PPARs) regulate the expression of genes for energy metabolism in a ligand-dependent manner. PPARs can influence fatty acid oxidation, the level of circulating triglycerides, glucose uptake and insulin sensitivity. Here, we demonstrate that 5-HEPE, 8-HEPE, 9-HEPE, 12-HEPE and 18-HEPE (hydroxylation products of eicosapentaenoic acid, EPA) obtained from ...
Hong Jun J a College of Life Science and Engineering, Henan University of Urban Construction , Pingdingshan 467036 , P. R. - - 2014
Panax notoginseng and its flowers are both well-known traditional Chinese medicinal herbs. To date, antimicrobial and antioxidant activities of flavonoids from P. notoginseng flowers (PNF) remain unclear. In this study, antimicrobial and antioxidant activities of flavonoids from PNF were investigated. The crude flavonoids were purified using a column (25 cm × 1.5 cm) packed ...
Lian Qianwen Q Key Laboratory of Bioelectrochemistry & Environmental Analysis of Gansu Province, College of Geography and Environment Science, Northwest Normal University, Lanzhou, 730070, PR - - 2014
A new type of tryptophan-functionalized graphene nanocomposite (Trp-GR) was synthesized by utilizing a facile ultrasonic method via π-π conjugate action between graphene (GR) and tryptophan (Trp) molecule. The material as prepared had well dispersivity in water and better conductivity than pure GR. The surface morphology of Trp-GR was characterized by ...
Sadouki Mohamed M Département de technologie alimentaire et de nutrition humaine 1 , Ecole Nationale Supérieure Agronomique, El-Harrach, Alger , Algérie - - 2014
Abstract Aims: To describe the effect of two food emulsifiers, lecithin (E322) and citric acid esters of mono-and diglycerides of fatty acids (E472c), on the intestinal absorption of lipids. Methods: The experiment was conducted on 24 male Wistar rats randomly assigned in three groups. For two groups of six rats, ...
Trinh Ly Thi Phi LT Department of Bioenergy Science and Technology, Chonnam National University, 77 Yongbong-ro, Buk-gu, Gwangju 500-757, Republic of Korea; Research Institute for Biotechnology and Environment, Nong Lam University, Hochiminh City, Viet - - 2014
An integrated detoxification process with electrodialysis (ED) followed by adsorption was performed to remove fermentation inhibitors from hemicellulose hydrolysates. The hydrolysates were prepared by oxalic acid pretreatment of yellow poplars at different temperatures. Of fermentation inhibitors, acetic acid showed high removal efficiency of about 90% and high transport rate during ...
Lin Gang G State Key Laboratory of Animal Nutrition, China Agricultural University, Beijing, 100193, - - 2014
Intrauterine growth restriction (IUGR) is one of the most common concerns in human obstetrics and domestic animal production. It is usually caused by placental insufficiency, which decreases fetal uptake of nutrients (especially amino acids) from the placenta. Amino acids are not only building blocks for protein but also key regulators ...
Atale Neha N Department of Biotechnology, Jaypee Institute of Information Technology, A-10, Sector-62, Noida, 201307, Uttar Pradesh, - - 2014
Pesticide-induced toxicity is a serious issue which has resulted in plethora of diseases all over the world. The organophosphate pesticide malathion has caused many incidents of poisoning such as cardiac manifestations. The present study was designed to evaluate the effect of Syzygium cumini on malathion-induced cardiotoxicity. Dose optimization of malathion ...
Liu Xiaoyan X Jiangsu Key Laboratory for Biomass-based Energy and Enzyme Technology, Huaiyin Normal University, Huai'an, China, - - 2014
The immobilized cellulase-producing mycelium of Trichoderma reesei was found to produce 2.9 U/ml of cellulase activity within 144 h while 2.1 U/ml of cellulase activity was produced within 120 h by the free mycelium of the same strain. When the immobilized mycelium of T. reesei was co-cultivated with the free ...
Schuchardt Jan Philipp JP Institute of Food Science and Human Nutrition, Leibniz University Hannover, Germany. Electronic address: - - 2014
Several supplementation studies with long-chain omega-3 polyunsaturated fatty acids (LC n-3 PUFA) describe an increase of EPA-derived hydroxy, epoxy and dihydroxy fatty acids in blood, while changes in levels of other LC n-3 and n-6 PUFA-derived oxylipins were minor. In order to investigate the kinetics of changes in oxylipin levels ...
Ren Tiegang T Fine Chemistry and Engineering Research Institute, College of Chemistry and Chemical Engineering, Henan University, Kaifeng 475004, People's Republic of - - 2014
Two series of quinoline derivatives containing pyrazole group were synthesized and characterized by means of (1)H NMR, FT-IR, MS, elemental analysis and X-ray single crystal diffraction, and their UV-vis absorption behavior and fluorescence properties were also measured. Moreover, the effects of acetic acid and triethylamine on the spectroscopic properties of ...
Fukuta Megumi M Graduate School of Engineering, Osaka University, 2-1 Yamadaoka, Suita, Osaka 565-0871, Japan; Japan Science and Technology Agency, CREST, 5 Sanbancho, Chiyoda-ku, Tokyo 102-0075, Japan. Electronic address: - - 2014
The adsorption mechanism of titanium-binding peptide (TBP) on metal oxide substrates was investigated by evaluating the adsorption behavior of ferritins with various alanine-substituted TBPs. Results revealed that (a) a positively charged amino acid, lysine (K) or arginine (R), in TBP can anchor ferritin to negative zeta-potential substrates, (b) the adsorption ...
Riedel Annett A Department of Nutritional and Physiological Chemistry, University of Vienna, Vienna, - - 2014
Pyridines are widely distributed in foods. Nicotinic acid (NA), a carboxylated pyridine derivative, inhibits lipolysis in adipocytes by activation of the orphan NA receptor (HM74A) and is applied to treat hyperlipidemia. However, knowledge on the impact of pyridine derivatives on intestinal lipid metabolism is scarce. This study was performed to ...
Sun Liqin L Department of Biological Engineering, College of Life Science, Yantai University, Shandong 264005, PR China. Electronic address: - - 2014
Water-soluble polysaccharides from Pavlova viridis and Sarcinochrysis marina Geitler (P0 and S0, respectively) and their degradation fragments (P1, P2, S1, S2 and S3) were screened for their antioxidant activity using 1,1-diphenyl-2-picrylhydrazyl (DPPH), hydroxyl-radical (OH) scavenging, lipid peroxidation (LPO) inhibition and the mouse red blood cells (RBCs) hemolysis assay. The physicochemical ...
Li XiaoLing X State Key Laboratory of Urban Water Resource and Environment, Harbin Institute of Technology, Harbin 150090, Heilongjiang, - - 2014
The effects of temperatures (15-55 °C) on the alkaline fermentation of sewage sludge were investigated in semi-continuous stirred tank reactors (semi - CSTR) at the pH of 10. The highest soluble chemical oxygen demand (SCOD) yield was obtained at 55 °C (764.2 mg/(gVS L d)), while the highest short chain fatty acids (SCFAs) yield ...
Li Xinjian X The College of Chemistry and Molecular Engineering, Zhengzhou University , Zhengzhou, Henan 450001, PR - - 2014
A novel protocol to synthesize tert-butyl esters from boronic acids or boronic acid pinacol esters and di-t-butyl dicarbonate has been successfully achieved. The cross-coupling reactions can produce up to 94% yields by using palladium acetate and triphenylphosphine as catalyst system, dioxane as a solvent. Moreover, a wide range of substrates ...
Santolla Maria Francesca MF Department of Pharmacy, Health and Nutritional Sciences, University of Calabria, 87036 Rende (CS), - - 2014
Nicotinic acid, also known as niacin, is the water soluble vitamin B3 used for decades for the treatment of dyslipidemic diseases. Its action is mainly mediated by the G protein-coupled receptor (GPR) 109A, however certain regulatory effects on lipid levels occur in a GPR109A- independent manner. The amide form of ...
Kocic Gordana G 1 Department of Biochemistry, Medical Faculty, University Nis , - - 2014
Abstract Sufficient intake of folic acid is necessary for normal embryogenesis, fetal, and neonatal development. Folic acid facilitates nucleic acid internalization, and protects cellular DNA from nuclease degradation. Human milk contains enzymes, antimicrobial proteins, and antibodies, along with macrophages, that protect against infections and allergies. However, little to no information ...
Olaimat Amin N AN Dept. of Food Science, Faculty of Agriculture and Food Science, Univ. of Manitoba, Winnipeg, MB, R3T 2N2, - - 2014
The antimicrobial activities of oriental mustard extract alone or combined with malic acid and EDTA were investigated against Salmonella spp. or Listeria monocytogenes at different temperatures. Five strain Salmonella or L. monocytogenes cocktails were separately inoculated in Brain Heart Infusion broth containing 0.5% (w/v) aqueous oriental mustard extract and incubated ...
Moore Simon J SJ School of Biosciences, University of Kent, Giles Lane, Canterbury, Kent CT2 7NJ, - - 2014
Bacillus megaterium is a bacterium that has been used in the past for the industrial production of vitamin B12 (cobalamin), the anti-pernicious anaemia factor. Cobalamin is a modified tetrapyrrole with a cobalt ion coordinated within its macrocycle. More recently, B. megaterium has been developed as a host for the high-yield ...
Hu Jia J Longevity Institute, Davis School of Gerontology, University of Southern California, Los Angeles, CA, 90089, USA; Department of Biological Sciences, School of Dornsife College of Letters, Arts and Sciences, University of Southern California, Los Angeles, CA, 90089, - - 2014
In mammals, extended periods of fasting leads to the accumulation of blood ketone bodies including acetoacetate. Here we show that similar to the conversion of leucine to acetoacetate in fasting mammals, starvation conditions induced ketone body-like acetic acid generation from leucine in S. cerevisiae. Whereas wild-type and ras2Δ cells accumulated acetic ...
Woyda-Ploszczyca Andrzej M AM Laboratory of Bioenergetics, Adam Mickiewicz University, Umultowska 89, 61-614 Poznan, - - 2014
Using isolated potato tuber mitochondria possessing uncoupling protein (StUCP), we found that, under non-phosphorylating conditions, the sensitivity of aldehyde (all trans-retinal or 4-hydroxy-2-nonenal)-induced and fatty acid (linoleic acid)-induced StUCP-mediated proton leaks to GTP is controlled by the endogenous ubiquinone (Q) reduction level. The action of StUCP activators was abolished by ...
Le Thanh-Blicharz Joanna J Department of Food Concentrates and Starch Products in Poznań, Institute of Agricultural and Food Biotechnology, Poznań, - - 2014
Resistant starches are type of dietary fibers. However, their physiological effects depend on the way they resist digestion in the gastrointestinal tract. The objective of this study was to examine the hypothesis that new type of RS4 preparations, of in vitro digestibility of about 50%, obtained by cross-linking and acetylation, ...
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