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Results 301 - 350 of 4178
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Yamada Ryosuke - - 2014
Kojic acid (5-Hydroxy-2-(hydroxymethyl)-4-pyrone) is one of the major secondary metabolites in Aspergillus oryzae. It is widely used in food, pharmaceuticals, and cosmetics. The production cost, however, is too high for its use in many applications. Thus, an efficient and cost-effective kojic acid production process would be valuable. However, little is ...
Ramlall Chandika C School of Life Sciences, University of KwaZulu-Natal, Westville Campus, Durban, 4001, South - - 2014
Increased air pollution in a number of developing African countries, together with reports of vegetation damage typically associated with acid precipitation in commercial forests in South Africa, has raised concerns over the potential impacts of acid rain on natural vegetation in these countries. Recalcitrant (i.e. desiccation sensitive) seeds of many ...
Hosseini Morteza M Department of Life Science Engineering, Faculty of New Sciences & Technologies, University of Tehran, Tehran, Iran. Electronic address: - - 2014
The enhancing effect of histidine and tryptophan on chemiluminescence (CL) of CdSe quantum dots (QDs)-H2O2 system was studied. This reaction is based on the catalytic effect of amino acids, causing a significant increase in the light emission, as a result of the reaction of quantum dots (QDs) with hydrogen peroxide. ...
Tamura Masazumi M Graduate School of Engineering, Tohoku University, Aoba 6-6-07, Aramaki, Aoba-ku, Sendai, 980-8579, Japan. - - 2014
Rh-MoOx/SiO2 is an effective heterogeneous catalyst for selective hydrogenation of amino acids to amino alcohols in a water solvent. MoOx modification of Rh drastically enhanced the activity and improved the selectivity and ee. Various amino alcohols were obtained in high yields (90-94%) with complete retention of configuration.
Holthausen Michael H MH Department of Chemistry, University of Toronto, 80 St. George St, Toronto Ontario M5S3H6 - - 2014
The dicationic imidazolium-phosphonium salt [(SIMes)PFPh2 ][B(C6 F5 )4 ]2 has been prepared and shown to exhibit remarkable Lewis acidity in stoichiometric reactions and acting as an effective Lewis acid catalyst for the hydrodefluorination of fluoroalkanes and the hydrosilylation of olefins.
Polo-Hernández Erica E Instituto de Neurociencias de Castilla y León (INCYL), Universidad de Salamanca, - - 2014
Our previous work has shown that oleic acid synthesized by astrocytes in response to serum albumin behaves as a neurotrophic factor in neurons, upregulating the expression of GAP-43 and MAP-2 proteins, which are respectively markers of axonal and dendrite growth. In addition, oleic acid promoted neuron migration and aggregation, resulting ...
Zhang Yan Y Tianjin Key Laboratory of Drug Delivery and High-Efficiency, School of Pharmaceutical Science and Technology, Tianjin University, 300072, Tianjin, People's Republic of - - 2014
In a previous study, a synergistic retardation effect of 1,4-cyclohexanediol and 1,2-hexanediol on percutaneous absorption and penetration of metronidazole (MTZ) was discovered. A complex formation between 1,4-cyclohexanediol and 1,2-hexanediol was proposed to be responsible for the observed effect. The objective of this study was to investigate the necessity of hydroxyl ...
Zhang Jing - - 2014
Abstract Cortex Pseudolaricis is the root bark of Pseudolarix amabilis Rehder found only in China and has been widely used as folk antifungal remedies in traditional Chinese medicine. In order to find the natural antifungal agents against mango anthracnose, eight compounds namely pseudolaric acid A (1), ethyl pseudolaric acid B ...
Cisneros Fausto H - - 2014
The effect of roasting of sacha-inchi (Plukenetia volubilis L.) seeds on the oxidative stability and composition of its oil was investigated. The seeds were subjected to light, medium and high roasting intensities. Oil samples were subjected to high-temperature storage at 60 ºC for 30 days, and evaluated for oxidation (peroxide ...
Neo Yun Ping - - 2014
Effects of heat treatment on structure and physicochemical properties of zein (Ze) and gallic acid loaded zein (Ze-GA) electrospun fiber mats were investigated. The electrospun fiber mats displayed different surface and physicochemical properties after heat-cured at 150 °C for 24 hr, which were closely related to the initial amount of ...
Boonyarikpunchai Wanvisa W Chulalongkorn University Drug and Health Products Innovation Promotion Center, Department of Pharmacology and Physiology, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok 10330, - - 2014
Rosmarinic acid (RA) was isolated from an ethanolic extract of Thunbergia laurifolia leaves. The antinociceptive activity of RA was assessed in mice using hot-plate, acetic acid-induced writhing, and formalin tests. The anti-inflammatory effects of RA were determined in two mouse models of carrageenan-induced paw edema and cotton pellet-induced granuloma formation. ...
Salakhutdinov Nariman F NF Vorozhtsov Institute of Organic Chemistry, Siberian Division, Russian Academy of Sciences, pr. akademika Lavrent'eva 9, Novosibirsk 630090, Russian Federation; Novosibirsk State University, Pirogova str. 2, Novosibirsk 630090, Russian - - 2014
This review is the first attempt at systematization of the literature data on the structures and activities of triglyceride-lowering agents which used in medical practice or are in development. The effects and mechanisms of action of statins, squalene synthase inhibitors, fibrates, PPARα and PPARα/γ agonists, nicotinic acid, omega-3 fatty acids ...
Zheng Ming-Ming - - 2014
Diglycerides and phytosterol ester were two important functional lipids. Phytosterol esters mixed with dietary diglyceride could not only influence body weight, but also prevent or reverse insulin resistance and hyperlipidemia. In this study, a kind of novel functional oil rich in both diglycerides and phytosterol esters was prepared with "one-pot" ...
Lamaziere Antonin A Université Pierre et Marie Curie 6, Assistance Publique Hôpitaux de Paris, Laboratory INSERM U1157/UMR CNRS , Hôpital Saint-Antoine, Paris, 7203 , - - 2014
Introduction: Automated lipidomic methods based on mass spectrometry (MS) are now proposed to screen a large variety of candidate drugs available that inhibit de novo lipid synthesis and replace tedious methods based on radiotracer incorporation. A major new interest in inhibitors of de novo lipogenesis is their proapoptotic effect observed ...
Sugimoto Naoshi N Baylor Institute for Immunology Research, Baylor Research Institute, Dallas, TX - - 2014
The recognition of cytoplasmic nucleic acid is critical for innate immune responses against microbial infection and is responsible for autoimmunity induced by dead cells. Here, we report the identification of a unique cytosolic nucleic acid cosensor in human airway epithelial cells and fibroblasts: DEAH (Asp-Glu-Ala-His) box polypeptide 29 (DHX29), a ...
Oboh Ganiyu - - 2014
Abstract Background: Chlorogenic acid is a major phenolic compound that forms a substantial part of plant foods and is an ester of caffeic acid and quinic acid. However, the effect of the structures of both chlorogenic and caffeic acids on their antioxidant and antidiabetic potentials have not been fully understood. ...
Fouladi Elham E Food Biopolymer Research Group, Food Science and Technology Department, Damghan Branch, Islamic Azad University, Damghan, Semnan, - - 2014
In this study, sago starch was hydrolyzed by 0.14M HCl for 6, 12, 18, and 24h, and then modified by propylene oxide at a concentration of 0% to 30% (v/w). The effects of hydrolysis and etherification on molecular weight distribution, physicochemical, rheological, and thermal properties of dually modified starch were ...
Cadavid-Rodríguez Luz Stella LS National University of Colombia, Engineering Department, Carrera 32 No 12-00, Palmira, Colombia. Electronic address: - - 2014
Screenings recovered from the inlet works of wastewater treatment plants were digested without pre-treatment or dilution using a lab-scale, leach-bed reactor. Variations in recirculation ratio of the leachate of 4 and 8 l/lreactor/day and pH values of 5 and 6 were evaluated in order to determine the optimal operating conditions for ...
Fokin Andrey A - - 2014
We present an effective sequence for the preparation of phosphonic acid derivatives of the diamondoids diamantane, triamantane, [121]tetramantane, and [1(2,3)4]pentamantane. The reactions of the corresponding diamondoid hydroxy derivatives with PCl3 in sulfuric or trifluoroacetic acid give mono- as well as di-dichlorophosphorylated diamondoids in high preparative yields.
Wang Mingming M Shanghai Key Laboratory of Regulatory Biology, School of Life Sciences, East China Normal University, Shanghai 200241, PR - - 2014
Dendrimers have shown great promise in the design of high efficient and low cytotoxic gene vectors. In this study, we synthesized a list of fluorobenzoic acid-modified dendrimers by a facile synthetic route and explored their potential applications as non-viral gene vectors. Fluorination on the aromatic rings significantly improves the transfection ...
Sievers-Engler Adrian A Institute of Pharmaceutical Sciences, University of Tübingen, Auf der Morgenstelle 8, 72076 Tübingen, - - 2014
A set of N-derivatized amino acids were separated into enantiomers on a tert-butylcarbamoylated quinine-based chiral stationary phase (CSP). Quantitative structure-property relationship (QSPR) studies were then employed to investigate the retention behavior and factors responsible for enantioselectivity. Computations were performed using a general linear model and a Free-Wilson matrix with indicator ...
Garde-Cerdán T T Instituto de Ciencias de la Vid y del Vino (Gobierno de La Rioja-CSIC-Universidad de La Rioja), Ctra. Mendavia-Logroño NA 134, Km. 90, 26071 Logroño, La Rioja, Spain. Electronic address: - - 2014
The aim of this work was to study the influence of foliar application of different nitrogen sources on grape amino acid content. The nitrogen sources applied to Tempranillo grapevines were proline, phenylalanine, urea, and two commercial nitrogen fertilisers, both without and with amino acids in their formulations. All treatments were ...
Neff Margaret R MR Ontario Ministry of the Environment, Sport Fish Contaminant Monitoring Program, Environmental Monitoring and Reporting Branch, 125 Resources Road, Toronto, Ontario M9P 3V6, - - 2014
Fish is often promoted as a healthy part of the human diet due its high content of long chain n-3 polyunsaturated fatty acids (LC-PUFA). Previous studies have shown that cooked fish can have different fatty acid profiles than raw fillets, depending on the cooking method and fish species. In this ...
Simcock Nicola K NK Institute of Neuroscience, Newcastle University, Newcastle upon Tyne, NE1 - - 2014
Obtaining the correct balance of nutrients requires that the brain integrates information about the body's nutritional state with sensory information from food to guide feeding behaviour. Learning is a mechanism that allows animals to identify cues associated with nutrients so that they can be located quickly when required. Feedback about ...
Hadzik B B Department of General Paediatrics, University Childrens' Hospital Duesseldorf, Duesseldorf, - - 2014
The aim of our report is to increase awareness that the antioxidant alpha-lipoic acid, which is marketed primarily as weight loss and energy supplement, has potentially lethal effects. A 14-year-old girl ingested in suicidal intention a large amount of alpha-lipoic acid, which led to multiorgan failure and subsequent death within ...
Li Na N State Key Laboratory of Oil and Gas Reservoir Geology and Exploitation, Chengdu University of Technology, Chengdu, 610059, People's Republic of - - 2014
The use of noble metal nanoparticles (NPs) as reductants in chemiluminescence (CL) has been reported only rarely owing to their high oxidation potentials. Interestingly, nucleophiles could dramatically lower the oxidation potential of Ag NPs, such that in the presence of nucleophiles Ag NPS could be used as reductants to induce ...
Leckie Regina L RL University of Pittsburgh, Department of Psychology, 210S. Bouquet St, Pittsburgh, PA 15260 USA; Center for the Neural Basis of Cognition, Pittsburgh, PA USA. Electronic address: - - 2014
Greater amounts of physical activity (PA) and omega-3 fatty acids have both been independently associated with better cognitive performance. Because of the overlapping biological effects of omega-3 fatty acids and PA, fatty acid intake may modify the effects of PA on neurocognitive function. The present study tested this hypothesis by ...
Deslauriers Jessica J Department of Physiology and Biophysics, Faculty of Medicine and Health Sciences, Université de Sherbrooke, 12[e] avenue Nord, Sherbrooke (QC), Canada J1H - - 2014
Some pathophysiological models of schizophrenia posit that prenatal inflammation sensitizes the developing brain to second insults in early life and enhances brain vulnerability, thereby increasing the risk of developing the disorder during adulthood. We previously developed a two-hit animal model, based on the well-established prenatal immune challenge with polyI:C, followed ...
Gorres Kelly L KL Departments of Molecular Biophysics and - - 2014
The lytic cycles of Epstein-Barr virus (EBV) and Kaposi sarcoma-associated herpesvirus (KSHV) are induced in cell culture by sodium butyrate (NaB), a short-chain fatty acid (SCFA) histone deacetylase (HDAC) inhibitor. Valproic acid (VPA), another SCFA and HDAC inhibitor, induces the lytic cycle of KSHV, but blocks EBV lytic reactivation. To ...
Wu Chunyan C Department of Biotechnology, Graduate School of Life Sciences and Biotechnology, BK21-PLUS, Korea University, Seoul 136-713, Republic of - - 2014
Intake of dietary aroma compounds may regulate cellular lipid metabolism. We demonstrated that trans-caryophyllene, a flavor compound in plant foods and teas, activates peroxisome proliferator-activated receptor (PPAR)-α through direct interaction with the ligand-binding domain of PPAR-α. The agonistic activity of trans-caryophyllene was investigated by the luciferase reporter assay, surface plasmon ...
Huang Xiaojie X College of Food Science and Engineering, Liaoning Medical University, Jinzhou, 121000, - - 2014
The effects of postharvest methyl jasmonate (MeJA) fumigation on the total soluble solids (TSS), titratable acidity (TA), ascorbic acid, total phenolic content (TPC), total monomeric anthocyanins (TMAs), individual anthocyanins, and antioxidant activity of blueberries stored at 1 °C for 28 days were evaluated. Prior to storage, the blueberries were fumigated with ...
Suzuki Hiromi H Department of Biological Sciences; Tokyo Metropolitan University; Tokyo, - - 2014
Studies using inhibitors of indole-3-acetic acid (IAA) transport, not only for efflux but influx carriers, provide many aspects of auxin physiology in plants. 1-Naphtoxyacetic acid (1-NOA), an analog of the synthetic auxin 1-N-naphtalene acetic acid (NAA), inhibits the IAA influx carrier AUX1. However, 1-NOA also shows auxin activity because of ...
Scholz Birgit B Lehrstuhl für Allgemeine Lebensmitteltechnologie, Technische Universität München , Maximus-von-Imhof-Forum 2, D-85350 Freising, - - 2014
A method for the analysis of phytostanyl fatty acid esters, the functional ingredients of cholesterol-lowering enriched foods, was developed. The procedure is based on (i) separation of the intact esters via reversed-phase ultrahigh-performance liquid chromatography; (ii) detection by atmospheric pressure chemical ionization-mass spectrometry; and (iii) quantitation using selected ion monitoring ...
Tuntiyasawasdikul Sarunya S Center for Research and Development of Herbal Health Products, Faculty of Pharmaceutical Sciences, Khon Kaen University, Khon Kaen, 40002, - - 2014
Kaempferia parviflora (K. parviflora) rhizomes have long been used in traditional folk medicines and as general health-promoting agents. Several biological activities of K. parviflora, especially its anti-inflammatory effect, are due to its major constituents, methoxyflavones. However, the oral bioavailability of these methoxyflavones has been shown to be low. The aim ...
Wei Y Y Cell Biology and Metabolism Program, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, - - 2014
Target of rapamycin complex 1 (TORC1) is a master regulator of metabolism in eukaryotes that integrates information from multiple upstream signaling pathways. In yeast, the Nitrogen permease regulators 2 and 3 (Npr2 and Npr3) mediate an essential response to amino-acid limitation upstream of TORC1. In mammals, the Npr2 ortholog, Nprl2, ...
Stevenson Timothy J TJ Department of Biological Sciences, College of Arts and Sciences, University of Alaska Anchorage. - - 2014
Arctic ground squirrels (Urocitellus parryii) are active for a scant three to five months of the year. During the active season adult squirrels compete for mates, reproduce, and fatten in preparation for hibernation while juvenile squirrels, weaned in early July, must grow and acquire sufficient fat to survive their first ...
Wu Jianting J Guangdong and Shenzhen Key Laboratory of Male Reproductive Medicine and Genetics, Institute of Urology, Peking University Shenzhen Hospital, Shenzhen PKU-HKUST Medical Center, Shenzhen, - - 2014
Glucose confers acid resistance to exponentially growing bacteria by repressing formation of the cAMP-CRP complex and consequently activating acid resistance genes. Therefore, in a glucose-rich growth environment, bacteria are capable of resisting acidic stresses due to low levels of cAMP-CRP. Here we reveal a second mechanism for the glucose-conferred acid ...
Bandiera Tiziano T Drug Discovery and Development, Istituto Italiano di Tecnologia, Via Morego 30, I-16163 Genova, Italy. Electronic address: - - 2014
N-acylethanolamine acid amidase (NAAA) is a cysteine amidase that hydrolyzes saturated or monounsaturated fatty acid ethanolamides, such as palmitoylethanolamide (PEA) and oleoylethanolamide (OEA). PEA has been shown to exert analgesic and anti-inflammatory effects by engaging peroxisome proliferator-activated receptor-α. Like other fatty acid ethanolamides, PEA is not stored in cells, but ...
Kilic Ismail I Trakya University, Faculty of Education, Edirne, Turkey. Electronic address: - - 2014
Ellagic acid (EA, C14H6O8) is a natural dietary polyphenol whose benefits in a variety of diseases shown in epidemiological and experimental studies involve anti-inflammation, anti-proliferation, anti-angiogenesis, anticarcinogenesis and anti-oxidation properties. In vitro radical scavenging and antioxidant capacity of EA were clarified using different analytical methodologies such as total antioxidant activity ...
Jones Edward H EH Ground Water and Ecosystems Restoration Division, National Risk Management Research Laboratory, Office of Research and Development, United States Environmental Protection Agency, 919 Kerr Research Drive, Ada, OK 74820, USA. Electronic address: - - 2014
The potential toxicity of nanoparticles (NPs) has received considerable attention, but there is little knowledge relating to the fate and transport of engineered ZnO NPs in the environment. Column experiments were performed at pH 7.3-7.6 to generate effluent concentrations and retention profiles for assessing the fate and transport of ZnO ...
Cao Shifeng S Nanjing Research Institute for Agricultural Mechanization, Ministry of Agriculture, Liuying 100, Nanjing 210014, PR China; College of Food Science and Technology, Nanjing Agricultural University, Nanjing 210095, Jiangsu, PR - - 2014
Two cultivars of loquat fruit were stored at 20°C for 10days to investigate the relationship between disease resistance, and fatty acid composition and activities of endogenous antioxidant enzymes. The results showed that decay incidence increased with storage time in both cultivars. A significantly lower disease incidence was observed in 'Qingzhong' ...
de Ferranti Sarah D SD 1Department of Cardiology, Boston Children's Hospital, Boston, MA, - - 2014
Background. Omega-3 fatty acids supplements lower triglyceride (TG) levels in adults; little pediatric information is available. We evaluated their effect in hypertriglyceridemic adolescents. Methods. Twenty-five patients aged 10 to 19 years with TG levels 150 to 1000 mg/dL were randomized to 6 months double-blind trial of Lovaza (~3360 mg docosahexaenoic ...
Yustiawati Graduate School of Environmental Science, Hokkaido University, Kita-ku, Kita 10 Nishi 5, Sapporo, 060-0810, Japan, - - 2014
When peat forest fires happen, it leads to burn soil and also humic acids as a dominant organic matter contained in peat soil as well as the forest. The structure and properties of humic acids vary depending on their origin and environment, therefore the transformation of humic acid is also ...
Chen Cong C Center for Mitochondrial Biology and Medicine, - - 2014
C75 (4-methylene-2-octyl-5-oxotetra- hydrofuran-3-carboxylic acid) is a synthetic fatty acid synthase (FASN) inhibitor with potential therapeutic effects in several cancer models. Mitochondrial β-ketoacyl-acyl carrier protein synthase (HsmtKAS) is a key enzyme in the newly discovered mitochondrial fatty acid synthesis pathway (mtFAS II) that can produce the substrate for lipoic acid (LA) ...
Goodarzi Boroojeni F F Institute of Animal Nutrition, Department of Veterinary Medicine, Freie Universität Berlin, Königin-Luise-Str. 49, 14195 Berlin, - - 2014
Poultry feed is a potential vector for pathogens. Heat processing and organic acid treatments may decontaminate feed and can affect bird performance as well as feed digestibility. The present study was performed to investigate the effect of different thermal treatments including pelleting (P), long-term conditioning at 85°C for 3 min (L), ...
Mikula Hannes H Institute of Applied Synthetic Chemistry, Vienna University of Technology, 1060, Vienna, Austria, - - 2014
The synthesis of 3-acyltetramic acids by C-acylation of pyrrolidine-2,4-diones was studied by density functional theory (DFT). DFT was applied to the mycotoxin tenuazonic acid (TeA), an important representative of these bioactive natural compounds. Lewis acid mediated C-acylation in combination with previous pH-neutral domino N-acylation-Wittig cyclization can be used for the ...
Averous Julien J INRA, UMR 1019 Nutrition Humaine, Centre de Clermont-Ferrand-Theix, F-63122 Saint Genès Champanelle, France; Université Clermont 1, UFR Médecine, UMR 1019 Nutrition Humaine, Clermont-Ferrand, France. Electronic address: - - 2014
The mammalian Target Of Rapamycin Complex 1 (mTORC1) is a master regulator of cell growth and metabolism. It controls many cell functions by integrating nutrient availability and growth factor signals. Amino acids, and in particular leucine, are among the main positive regulators of mTORC1 signaling. The current model for the ...
Knipp Ralph J RJ Department of Chemistry, University of Louisville, Louisville, KY 40292, - - 2014
The relative cleavage of an alcohol from a panel of amino esters and amino carbonates via intramolecular cyclization was examined as a mechanism for substrate release. Thermal stability at 37 °C was observed only for the 7-membered ring progenitors. Applicability of the approach was illustrated by δ-lactam formation within a ...
Wang Renlei - - 2014
The effects of exogenous ascorbic acid (AsA) and reduced glutathione (GSH) on antioxidant enzyme activities [superoxide dismutase (SOD), ascorbate peroxidase (APX), and glutathione reductase (GR)] and the contents of malondialdehyde (MDA) and H2O2, as well as of endogenous AsA and GSH, in the chloroplasts of two rice cultivars, the salt-tolerant ...
Zhang Qian - - 2014
Graphene-TiO2 was obtained by reduction of graphite oxide by the hydrothermal method. Using photocatalytic activity to reduce carbon dioxide to methanol and formic acid was investigated in this study. The results show that the graphene loading affects the absorption of light in the visible light region. A larger surface area ...
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