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Yu Jia-Le JL State Key Laboratory of Bioreactor Engineering, School of Biotechnology, East China University of Science and Technology, 130 Meilong Road, Shanghai, 200237, - - 2014
The C6 dicarboxylic acid, adipic acid, is an important platform chemical in industry. Biobased production of adipic acid is a promising alternative to the current petrochemical route. Here we report biosynthesis of adipic acid using an artificial pathway inspired by the reversal of beta-oxidation of dicarboxylic acids. The biosynthetic pathway ...
Liu Hung-Wen - - 2014
Toona Sinensis (T. sinensis) leaf (TSL) has been shown to lower plasma triacylglycerol levels and diminish the size of visceral fat cells in vivo. The molecular mechanism of TSL ethanol extract (TSL-E) on lipid metabolism in 3T3-L1 adipocytes was investigated in this study. Oil Red O staining as well as ...
Teramoto Hidetoshi - - 2014
Silk fibroin incorporated with unnatural amino acids was produced by in vivo feeding of p-chloro-, p-bromo-, and p-azido-substituted analogues of L-phenylalanine (Phe) to transgenic silkworms (Bombyx mori) that expressed a mutant of phenylalanyl-tRNA synthetase with expanded substrate recognition capabilities in silk glands. Cutting down the content of Phe in the ...
Peterson Eric C EC Department of Chemical Engineering, Dupuis Hall, 19 Division St. Queen's University, Kingston Ontario, Canada, - - 2014
Through the use of high partial pressures of CO2 (pCO2 ) to achieve temporary pH reductions in two-phase partitioning bioreactors (TPPBs), improved pH dependent partitioning of butyric acid was observed which achieved in situ product recovery (ISPR), alleviating end-product inhibition (EPI) during the production of butyric acid by Clostridium tyrobutyricum ...
Isca Vera M S VM Department of Chemistry & QOPNA, University of Aveiro, Campus de Santiago, 3810-193 Aveiro, Portugal. Electronic address: - - 2014
Salicornia ramosissima J. Woods is considered, in the Iberian Peninsula and France, a gourmet product. Nevertheless, is one of the less studied Salicornia species. In this work, GC-MS was employed to, for the first time; fully characterise the lipophilic profile of S. ramosissima and to assess the effect of natural ...
Zhao Hong H Key Laboratory of Chinese Materia Medica, Heilongjiang University of Chinese Medicine, Ministry of Education, Harbin 150040, China; Key Laboratory of Biological Medicine Preparations, Institute of Pharmacy, Jiamusi University, Jiamusi 154007, - - 2014
Four purified polysaccharide fractions from seeds of Plantago depressa (PDSP-1, PDSP-2, PDSP-3 and PDSP-4) were obtained by isolation and purification using DEAE-52 cellulose and Sephacryl S-400 HR chromatography. Basic physicochemical properties including molecular weight, chemical composition, FT-IR and glycosidic linkage of these fractions were investigated. They seemed to be homogeneous ...
Yang Huaiyu - - 2014
Amino acid transporters in plants are crucial for distributing amino acids between plant organs and cellular compartments. The H(+)-coupled plasma membrane transporter CAT1 (cationic amino acid transporter 1) facilitates the high-affinity uptake of basic amino acids. The uptake of lysine (Lys) via the roots was not altered in loss-of-function mutants, ...
Dudek Magdalena M Department of Pharmacodynamids, Jagiellonian University, Medical College, Kraków, Poland. Electronic address: - - 2014
The cardiovascular effects of alpha lipoic acid were evaluated in isolated rat hearts exposed to ischemia-reperfusion injury in vitro. Alpha-lipoic acid raised the level of sulfane sulfur playing an important role in the release of hydrogen sulfide. H2S was shown to prevent the post-reperfusion arrhythmias and to protect the cardiomyocytes ...
Beer Kenneth R KR Kenneth R Beer MD - General, Esthetic and Surgical Dermatology, West Palm Beach, FL, - - 2014
Botulinum toxins are currently used to reduce facial muscle activity, and hyaluronic acid is used to correct volume loss. This study evaluates the combination of abobotulinumtoxinA (Dysport) and hyaluronic acid 20 mg/mL (Perlane) for rejuvenating specific areas of the upper face. Subjects (n = 20) with mild to moderate temporal volume loss as ...
Dugan Christine E CE Department of Nutritional Sciences, University of Connecticut, Storrs, - - 2014
Metabolic syndrome (MetS), characterized by central obesity, dyslipidemias, hypertension, and hyperglycemia, impacts 34 percent of the U.S. adult population. MetS has been demonstrated to be affected by dietary components. Data from epidemiological studies and clinical interventions suggest that one or more dairy components might directly affect MetS parameters. For example, ...
Espahbod Camelia C NYU College of Dentistry, New York, - - 2014
Data sourcesMedline, Embase and the reference lists of identified articles were also scanned for relevant papers.Study selectionOnly randomised controlled trials in English were considered.Data extraction and synthesisTwo reviewers extracted data independently and study quality was assessed using the Jadad score. Meta-analysis was conducted.ResultsFour RCTs with a total of 183 patients ...
Kim Myung Chul MC College of Pharmacy, Chung-Ang University, Seoul 156-756, - - 2014
To investigate the underlying mechanisms of C18 fatty acids (stearic acid, oleic acid, linoleic acid and α-linolenic acid) on mast cells, we measured the effect of C18 fatty acids on intracellular Ca(2+) mobilization and histamine release in RBL-2H3 mast cells. Stearic acid rapidly increased initial peak of intracellular Ca(2+) mobilization, ...
Pszczolkowski Maciej A - - 2014
The idea of enhancing insecticide efficacy against phytophagous insects with feeding stimulators was proposed as early as the 1960s, and a number of insect feeding stimulators based on sugars, molasses, and cottonseed extracts, biologically active at relatively high (5% and higher) concentrations, have been advocated. Here, we show that an ...
Outlaw Victor K VK Department of Chemistry, The Johns Hopkins University, Remsen Hall, 3400 N. Charles Street, Baltimore, MD 21218, - - 2014
Despite a rising demand for anti-obesity therapeutics, few effective pharmacological options are clinically available that target the synthesis and accumulation of body fat. Moderate inhibition of mammalian glycerol-3-phosphate acyltransferase (GPAT) with 2-(alkanesulfonamido)benzoic acids has recently been described in vitro, accompanied by promising weight loss in vivo. In silico docking studies ...
Machin John T - - 2014
The administration of tranexamic acid to decrease blood loss in primary total hip replacement is established. In this observational study three different regimes of tranexamic acid were used to investigate the effects of combined intravenous and topical administration of tranexamic acid to a single intravenous bolus given at induction or ...
Lebda Mohamed M Department of Biochemistry, Faculty of Veterinary Medicine, Alexandria University, - - 2014
Acrylamide is very toxic to various organs and associated with significant increase of oxidative stress and depletion of antioxidants. Alpha-lipoic acid enhances cellular antioxidant defense capacity, thereby protecting cells from oxidative stress. This study aimed to evaluate the protective role of alpha-lipoic acid on the oxidative damage induced by acrylamide ...
Esquivel-Elizondo S S Bioprocesses Department, Unidad Profesional Interdisciplinaria de Biotecnología, Instituto Politécnico Nacional, P.O. Box 07340, Mexico City, - - 2014
Dark fermentation for bio-hydrogen (bio-H2) production is an easily operated and environmentally friendly technology. However, low bio-H2 production yield has been reported as its main drawback. Two strategies have been followed in the past to improve this fact: genetic modifications and adjusting the reaction conditions. In this paper, the second ...
Ammar Ehab Mohamed EM William G. Lowrie Department of Chemical and Biomolecular Engineering, The Ohio State University, 140 West 19th Avenue, Columbus, OH, 43210, - - 2014
Propionic acid is currently produced mainly via petrochemicals, but there is increasing interest in its fermentative production from renewable biomass. However, the current propionic acid fermentation process suffers from low product yield and productivity. In this work, the gene encoding phosphoenolpyruvate carboxylase (PPC) was cloned from Escherichia coli and expressed ...
Bi Hongkai H Department of Microbiology and 3Biochemistry, B103 Chemical and Life Sciences Laboratory, University of Illinois, 601 S. Goodwin Ave, Urbana, Illinois 61801, - - 2014
In Xanthomonas campestris pv. campestris (Xcc), the proteins encoded by the rpf (regulator of pathogenicity factor) gene cluster produce and sense a fatty acid signal molecule called diffusible signaling factor (DSF, 2(Z)-11-methyldodecenoic acid). RpfB was reported to be involved in DSF processing and was predicted to encode an acyl-CoA ligase. ...
Botha Claude C Centre for Digestive Diseases, Blizard Institute of Cell & Molecular Science, Wingate Institute of Neurogastroenterology, Barts and the London School of Medicine & Dentistry, Queen Mary University of London, London, - - 2014
Autonomic nervous system dysfunction has been implicated in visceral hypersensitivity. However, the specific contribution of the parasympathetic nervous system (PNS) is unclear. We aimed to determine whether physiological and pharmacological manipulation of parasympathetic tone influences the development of hypersensitivity in a validated model of acid-induced oesophageal pain. Prior to, and ...
Schebb Nils Helge NH Institute for Food Toxicology and Analytical Chemistry, University of Veterinary Medicine Hannover, Germany. Electronic address: - - 2014
It is believed that many of the beneficial effects of long-chain omega-3 polyunsaturated fatty acids (LC n-3 PUFA) are mediated by their oxidized metabolites, the oxylipins. The formation and biological role of many cytochrome P450 and lipoxygenase derived hydroxy, epoxy and dihydroxy FA, particularly of oxylipins esterified in polar lipids ...
Lee In-Kyoung IK Division of Biotechnology and Advanced Institute of Environment and Bioscience, Chonbuk National University, 79 Gobong-ro, Iksan-si 570-752, Republic of - - 2014
Ten phenylpropanoic acid esters were isolated from an ethanolic extract of Korean propolis. Their structures were elucidated by spectroscopic methods including NMR and ESI-MS. Caffeic acid esters with catechol moiety exhibited significant ABTS and DPPH radical scavenging activity and protective effect against DNA damage by a Fenton reaction.
Pappas Ioannis A IA Chemical Process Engineering Research Institute, LPRE, 6th km Harilaou Thermi Road, 57001 Thessaloniki, Greece; Aristotle University, Department of Forestry and Natural Environment, Range Ecology Laboratory, 54124 Thessaloniki, Greece. Electronic address: - - 2014
The effect of dilute acid pretreatment severity on the bioconversion efficiency of Phalaris aquatica lignocellulosic biomass into fermentable sugar monomers was studied. The pretreatment conditions were expressed in a combined severity factor (CSF), ranged from 0.13 to 1.16. The concentration of xylose and total monomeric sugars released from hemicellulose increased ...
Botsoglou Evropi E Laboratory of Hygiene of Foods of Animal Origin, Faculty of Veterinary Medicine, University of Thessaly, Karditsa, - - 2014
Our previous study has demonstrated the protective effects of olive leaf extracts on the oxidation of pork patties from n-3 fatty acid-enriched meat during refrigerated storage. The target of the present study was to examine these effects during frozen storage. Results showed that frozen storage accelerated (P=0.05) both lipid and ...
Widenhorn-Müller Katharina K Transfer Center for Neuroscience and Learning, University Hospital, Ulm, Germany; Department of Psychiatry, University Hospital, Ulm, Germany. Electronic address: - - 2014
To determine whether supplementation with the long-chain omega-3 polyunsaturated fatty acids eicosapentaenoic (EPA) and docosahexaenoic acid (DHA) affects behavioral symptoms and cognitive impairments in children 6-12 years of age diagnosed with attention-deficit/hyperactivity disorder (ADHD). The randomized, double-blind placebo-controlled 16 weeks trial was conducted with 95 children diagnosed with ADHD according ...
Hao Guangfei G State Key Laboratory of Food Science and Technology, School of Food Science and Technology, Jiangnan University, Wuxi, 214122, People's Republic of - - 2014
Malic enzyme (ME) catalyses the oxidative decarboxylation of L-malate to pyruvate and provides NADPH for intracellular metabolism, such as fatty acid synthesis. Here, the mitochondrial ME (mME) gene from Mortierella alpina was homologously over-expressed. Compared with controls, fungal arachidonic acid (ARA; 20:4 n-6) content increased by 60 % without affecting the ...
Katz Jonathan R JR School of Life Sciences, University of Sussex, Falmer, Brighton, BN1 9QJ, - - 2014
The interaction of small molecules with non-covalent assemblies is of wide interest. The use of a magnetically active reporter nucleus allows information to be obtained in the presence of spectral overlap or in cases of high dynamic range. In this paper, we explore the interaction of a larger probe molecule, ...
Maeda K K Department of Biological Mechanisms and Functions, Graduate School of Bioagricultural Sciences, Nagoya University, Chikusa, Nagoya, Aichi, 464-8601, - - 2014
Acivicin is an inhibitor of γ-glutamyl transpeptidase and glutamine amidotransferase. When grown on a synthetic minimal agar medium, acivicin strongly inhibited the growth of Magnaporthe oryzae and Alternaria brassicicola, and to a lesser extent, Botrytis cinerea. However, only partial or marginal growth inhibition was observed with regard to Fusarium sporotrichioides ...
Lynch Caitlin C Department of Pharmaceutical Sciences, University of Maryland School of Pharmacy, Baltimore, Maryland - - 2014
Accumulating evidence suggests that activation of mouse constitutive androstane receptor (mCAR) alleviates type 2 diabetes and obesity by inhibiting hepatic gluconeogenesis, lipogenesis, and fatty acid synthesis. However, the role of human (h) CAR in energy metabolism is largely unknown. The present study aims to investigate the effects of selective hCAR ...
Radhakumari M M Chemical Engineering Division, CSIR-Indian Institute of Chemical Technology, Hyderabad 500007, - - 2014
The main objective of the present study is aimed to optimize the process parameters for the production of glucose from karanja seed cake. The Taguchi robust design method with L9 orthogonal array was applied to optimize hydrolysis reaction conditions and maximize sugar yield. Effect of temperature, acid concentration, and acid ...
Al Fahad Ahmed A School of Chemistry, University of Bristol, Cantock's Close, Bristol, BS8 1TS - - 2014
A series of directed knockout experiments, combined with an in vitro assay of pathway components, has elucidated for the first time the chemical steps involved in the biosynthesis of the tropolone class of fungal maleic anhydrides. The pathway involves the stepwise oxidation of aldehyde and methyl carbon atoms to form ...
Velásquez-Cock J J Facultad de Ingeniería Química, Universidad Pontificia Bolivariana, Circular 1° N° 70-01, Medellín, - - 2014
Chitosan films reinforced with bacterial cellulose (BC) nanoribbons were studied to understand the influence of acid (acetic and lactic acids) on the reinforcing effect. For both acids, the maximum concentration of the reinforcing constituent was 5 wt% with respect to the dry weight of chitosan. The infrared spectra, mechanical properties, ...
Gibson E L EL Department of Psychology, Whitelands College, University of Roehampton, Holybourne Avenue, London, SW15 4JD, UK, - - 2014
Effective functioning of the neurotransmitter serotonin is important for optimal cognitive and emotional function. Dietary supplements able to increase availability to the brain of the precursor amino acid, tryptophan (TRP), and thereby enhance serotonin synthesis, can have measurable impact on these psychological processes. This study involves a randomised controlled trial ...
Liu Xiaofang X Key Laboratory of Luminescent and Real-Time Analytical Chemistry, Ministry of Education, College of Chemistry and Chemical Engineering, Southwest University, Chongqing, 400715, People's Republic of - - 2014
In this paper, graphene-multiwall carbon nanotube-gold nanocluster (GP-MWCNT-AuNC) composites were synthesized and used as modifier to fabricate a sensor for simultaneous detection of ascorbic acid (AA), dopamine (DA), and uric acid (UA). The electrochemical behavior of the sensor was investigated by electrochemical impedance spectroscopy (EIS), cyclic voltammetry (CV) and differential ...
Esteban-Torres María M Laboratorio de Biotecnología Bacteriana, Instituto de Ciencia y Tecnología de Alimentos y Nutrición, ICTAN-CSIC , Juan de la Cierva 3, 28006 Madrid, - - 2014
The gene lp_1002 from Lactobacillus plantarum WCFS1 encoding a putative lipase/esterase was cloned and overexpressed in Escherichia coli BL21(DE3). The purified Lp_1002 protein was biochemically characterized. Lp_1002 is an arylesterase which showed high hydrolytic activity on phenyl acetate. Although to a lesser extent, Lp_1002 also hydrolyzed most of the esters ...
Shioda Norifumi N Tohoku University, - - 2014
α-Synuclein (αSyn) accumulation in dopaminergic (DA) neurons is partly regulated by long-chain polyunsaturated fatty acids (PUFAs). We found that fatty acid-binding protein 3 (FABP3, H-FABP), a factor critical for arachidonic acid (AA) transport and metabolism in brain, is highly expressed in DA neurons. Fabp3 knockout (Fabp3(-/-)) mice were resistant to ...
Le Goff Wilfried W INSERM UMR_S1166, Team 4: Integrative Biology of Atherosclerosis, F-75013 Paris, France; Université Pierre et Marie Curie-Paris6, F-75005 Paris, France; Institute of Cardiometabolism and Nutrition (ICAN), Pitié-Salpêtrière Hospital, F-75013 Paris, France. Electronic address: - - 2014
Omega-3 fatty acids (n-3) FA are reported to be protective against cardiovascular disease (CVD), notably through their beneficial action on atherosclerosis development. In this context dietary intake of long-chain marine eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) is recommended and randomised trials largely support that EPA and DHA intake is ...
Verma Kushagra K Department of Orthopaedics, Jefferson Medical College, Thomas Jefferson University, 834 Chestnut Street, Philadelphia, PA - - 2014
Antifibrinolytics can reduce intraoperative blood loss. The primary aim of this study was to determine the efficacy of intraoperative tranexamic acid, epsilon-aminocaproic acid, and placebo at reducing perioperative blood loss and the transfusion rate in patients with adolescent idiopathic scoliosis undergoing posterior spinal arthrodesis. This is a prospective, randomized, double-blind ...
Chen Wei-Nan - - 2014
Substance P is an important neuropeptide released from nociceptors to mediate pain signals. We recently revealed antinociceptive signaling by substance P in acid-sensing ion channel 3 (ASIC3)-expressing muscle nociceptors in a mouse model of acid-induced chronic widespread pain. However, methods to specifically trigger the substance P antinociception were still lacking. ...
Karlsdottir Magnea G MG Matis ohf. Icelandic Food and Biotech R&D, Biotechnology and Biomolecules, Vinlandsleid 12, IS-113 Reykjavík, Iceland; University of Iceland, Department of Food Science, Vinlandsleid 12, IS-113 Reykjavík, Iceland. Electronic address: - - 2014
Lipid decomposition of saithe (Pollachius virens) light and dark muscles was monitored during frozen storage at -25°C of raw (up to 18months) and cooked products. Samples were cooked after 0, 6 and 12months raw storage then refrozen and stored at -25°C for 12months to determine the stability of cooked-then-stored samples. ...
Kim Kyu-Bong KB College of Pharmacy, Dankook University, 119 Dandae-ro, Cheonan, Chungnam,330-714, - - 2014
α-Linolenic acid (ALA), a carboxylic acid with 18 carbons and three cis double bonds, is an essential fatty acid needed for human health and can be acquired via regular dietary intake of foods that contain ALA or dietary supplementation of foods high in ALA, for example flaxseed. ALA has been ...
Shen Liang L Department of Chemical and Biochemical Engineering, College of Chemistry and Chemical Engineering, The Key Lab for Synthetic Biotechnology of Xiamen City, Xiamen University, Xiamen 361005, - - 2014
The two-stage process, coupling volatile fatty acids (VFAs) fermentation and poly(hydroxybutyrate-hydroxyvalerate) (P(HB/HV)) biosynthesis, was investigated for five waste organic materials. The overall conversion efficiencies were glycerol>starch>molasses>waste sludge>protein, meanwhile the maximum P(HB/HV) (1.674g/L) was obtained from waste starch. Altering the waste type brought more effects on VFAs composition other than the ...
Stewart-Sloan Charlotte R CR Departments of Materials Science and Engineering and Chemical Engineering, Massachusetts Institute of Technology , Cambridge, Massachusetts 02139, United - - 2014
Block copolymers composed of poly(oligo ethylene glycol methyl ether methacrylate) and poly(2-vinylpyridine) are disordered in the neat state but can be induced to order by protonation of the P2VP block, demonstrating a tunable and responsive method for triggering assembly in thin films. Comparison of protonation with the addition of salts ...
Flanigan Patrick M PM Department of Chemistry and Biochemistry, Southwestern University, Georgetown, TX 78626, United States. Electronic address: - - 2014
In this study, we determined the effect of cultivar on total and individual anthocyanin concentrations and phenolic acid levels in eight purple basil varieties and examined the relationship between anthocyanin content, phenolic acid composition, and antioxidant properties. Cultivar had a significant influence on total anthocyanin concentrations as well as individual ...
Freitag Johannes J Department of Biology, Philipps-Universität Marburg, Karl-von-Frisch-Str. 8, 35032 Marburg, Germany; Senckenberg Gesellschaft für Naturforschung, Cluster for Integrative Fungal Research, Georg-Voigt-Str. 14-16, 60325 Frankfurt am Main, - - 2014
Many microorganisms secrete surface-active glycolipids. The basidiomycetous fungus Ustilago maydis produces two different classes of glycolipids, mannosylerythritol lipids (MEL) and ustilagic acids (UAs). Here we report that biosynthesis of MELs is partially localized in peroxisomes and coupled to peroxisomal fatty acid degradation. The acyltransferases, Mac1 and Mac2, which acylate mannosylerythritol ...
Li Jianfang J School of Pharmaceutical Sciences, Shandong University of Traditional Chinese Medicine, Jinan 250355, China; Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Shandong University, Jinan 250012, - - 2014
Natural small-molecule products are promising lead compounds for developing a generation of novel antimicrobials agents to meet the challenge of antibiotic-resistant pathogens. To facilitate the search for novel anti-virulence agents, we chose a virulence factor of type three secretion system (T3SS) as a drug target to screen candidates from a ...
Emran Sahar S Institute of Healthy Ageing, Department of Genetics, Evolution and Environment, University College London, London WC1E 6BT, United - - 2014
Dietary restriction (DR), defined as a moderate reduction in food intake short of malnutrition, has been shown to extend healthy lifespan in a diverse range of organisms, from yeast to primates. Reduced signalling through the insulin/IGF-like (IIS) and Target of Rapamycin (TOR) signalling pathways also extend lifespan. InDrosophila melanogaster the ...
León-Rivera Ismael I Centro de Investigaciones Químicas, Universidad Autónoma del Estado de Morelos, Avenida Universidad 1001, Col. Chamilpa, 62209, Cuernavaca, Morelos, Mexico, - - 2014
The methanol-soluble extract from the root of Ipomoea tyrianthina was studied in order to isolate compounds with activity on the central nervous system and vasorelaxant effects. Chromatographic methods were used to isolate and purify seven new glycolipids (2-8). The structures of compounds 1-8 were elucidated by a combination of NMR ...
Yamada Ryosuke - - 2014
Kojic acid (5-Hydroxy-2-(hydroxymethyl)-4-pyrone) is one of the major secondary metabolites in Aspergillus oryzae. It is widely used in food, pharmaceuticals, and cosmetics. The production cost, however, is too high for its use in many applications. Thus, an efficient and cost-effective kojic acid production process would be valuable. However, little is ...
Ramlall Chandika C School of Life Sciences, University of KwaZulu-Natal, Westville Campus, Durban, 4001, South - - 2014
Increased air pollution in a number of developing African countries, together with reports of vegetation damage typically associated with acid precipitation in commercial forests in South Africa, has raised concerns over the potential impacts of acid rain on natural vegetation in these countries. Recalcitrant (i.e. desiccation sensitive) seeds of many ...
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