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Machado Lorenna L School of Marine and Tropical Biology, James Cook University, Townsville, Queensland, Australia ; Centre for Sustainable Tropical Fisheries and Aquaculture, James Cook University, Townsville, Queensland, - - 2014
This study aimed to evaluate the effects of twenty species of tropical macroalgae on in vitro fermentation parameters, total gas production (TGP) and methane (CH4) production when incubated in rumen fluid from cattle fed a low quality roughage diet. Primary biochemical parameters of macroalgae were characterized and included proximate, elemental, ...
Crick Eric W EW R.N. Adams Institute for Bioanalytical Chemistry, Department of Chemistry, University of Kansas, 2030 Becker Drive, Lawrence, KS - - 2014
The goal of this study was to use a status epilepticus steady-state chemical model in rats using the convulsant, 3-mercaptopropionic acid (3-MPA), and to compare the changes in striatal neurotransmission on a slow (5 minute) and fast (60 second) timescale. In vivo microdialysis was combined with electrophysiological methods in order ...
Simplício Janaína A JA Programa de Pós-Graduação em Farmacologia, Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo (USP), Ribeirão Preto, SP, - - 2014
We investigated the mechanisms underlying the vasorelaxant and hypotensive actions of the labdane-type diterpene ent-3-acetoxy-labda-8(17),13-dien-15-oic acid (labda-15-oic acid). Vascular reactivity experiments were performed in aortic rings isolated from male Wistar rats. cAMP and cGMP were measured by enzyme immunoassay (EIA) whereas nitrate measurement was performed by chemiluminescence. Nitric oxide (NO) ...
Romano Andrea A Research and Innovation Centre, Fondazione Edmund Mach, via Mach 1, San Michele all'Adige, Italy. Electronic address: - - 2014
Decarboxylation pathways are widespread among lactic acid bacteria; their physiological role is related to acid resistance through the regulation of the intracellular pH and to the production of metabolic energy via the generation of a proton motive force and its conversion into ATP. These pathways include, among others, biogenic amine ...
Xu Pan P State Key Laboratory of Coordination Chemistry, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210093, P. R. China. - - 2014
A visible-light-induced decarboxylative trifluoromethylation of α,β-unsaturated carboxylic acids, which uses the Togni reagent as the CF3 source is disclosed. The corresponding trifluoromethylated alkenes were obtained in moderate to high yields with excellent functional group tolerance at ambient temperature. Preliminary mechanistic analyses suggest a radical-type mechanism.
Riedel Annett A Department of Nutritional and Physiological Chemistry, University of Vienna, Althanstrasse 14 (UZAII) Room 2B578, A-1090 Vienna, Austria. - - 2014
N-Methylpyridinium (NMP) is a thermal degradation product of trigonelline formed upon coffee roasting and hypothesized to exert several health benefits in humans. Since for trigonelline evidence for hypoglycemic effects exists, we examined whether NMP also affects mechanisms of glucose utilization and cellular energy formation. For this purpose, the impact of ...
Chen Liwei L School of Chemical and Biomedical Engineering, College of Engineering, Nanyang Technological University, Singapore, - - 2014
Fatty acid-derived biofuels and biochemicals can be produced in microbes using β-oxidation pathway engineering. In this study, the β-oxidation pathway of Saccharomyces cerevisiae was engineered to accumulate a higher ratio of medium chain fatty acids (MCFAs) when cells were grown on fatty acid-rich feedstock. For this purpose, the haploid deletion ...
Adwan Lina L Department of Biomedical & Pharmaceutical Sciences, University of Rhode Island, Kingston, RI, - - 2014
Environmental exposure to lead (Pb) early in life results in a latent upregulation of genes and products associated with Alzheimer's disease (AD), particularly the plaque forming protein amyloid beta (Aβ). Furthermore, animals exposed to Pb as infants develop cognitive decline and memory impairments in old age. Studies from our lab ...
Pontes Adriana S AS Laboratório de Imunologia Celular Aplicada à Saúde, Fundação Oswaldo Cruz, FIOCRUZ Rondônia, Porto Velho-RO, - - 2014
The in vitro effects of LAAO, an l-amino acid oxidase isolated from Calloselasma rhodosthoma snake venom, on isolated human neutrophil function were investigated. LAAO showed no toxicity on neutrophils. At non-cytotoxic concentrations, LAAO induced the superoxide anion production by isolated human neutrophil. This toxin, in its native form, is also able ...
Utrilla-Coello R G RG Universidad Autónoma Metropolitana-Iztapalapa, Departamento de Ingeniería de Procesos e Hidráulica, Apartado Postal 55-534, México, D.F. 09340, Mexico; Centro de Desarrollo de Productos Bióticos (CEPROBI) del Instituto Politécnico Nacional, Yautepec, Morelos, - - 2014
The acid hydrolysis of native corn starch at 35°C was monitored during 15 days. After this time, the residual solids were about 37.0±3.0%. First-order kinetics described the hydrolysis data, giving a constant rate of kH=0.18±0.012days(-1). Amylose content presented a sharp decrement of about 85% and X-ray diffraction results indicated a ...
Shibata Norio N Department of Frontier Materials, Graduate School of Engineering, Nagoya Institute of Technology, Gokiso, Showa-ku, Nagoya 466-8555, Japan. - - 2014
Inorganic as well as organic base catalysis was found to be effective for diastereoselective Mannich additions of malonic acid derivatives to (SS)-N-(tert-butanesulfinyl)-3,3,3-trifluoroacetaldimine. In the presence of catalytic amounts of inorganic bases, n-BuLi or DMAP, the reaction gives the corresponding (R,SS)-β-aminomalonates in good yield and with diastereoselectivity up to 9/1 dr. ...
Türky- Meltem M Institute of Food Safety, Ankara University Diskapi Campus, Diskapi, 06110, Ankara, - - 2014
This study was conducted to determine the differences in some analytical properties of four apricot cultivars and to determine the changes in these analytical properties during sulfuring and sun-drying. There were significant differences in the contents of polyphenol, carotenoid and organic acid (OA) as well as antioxidant activities (AOAs) of ...
Yu Xiao-Zhang XZ The Guangxi Key Laboratory of Theory and Technology for Environmental Pollution Control, College of Environmental Science & Engineering, Guilin University of Technology, Guilin, 541004, People's Republic of China, - - 2014
Solution culture was carried to investigate capacity of synthetic aminopolycarboxylic acids (ethylenediamine tetraacetate, N-hydroxyethylenediaminetriacetic acid, and diethylenetriamine-pentaacetate) for enhancing botanical removal and transport of heavy metals (Cu and Zn) by plants. Biodegradable organic acids (citric acid, malic acid, and oxalic acid) were also selected as alternatives to compare them with ...
Basak Souvik S School of Chemical & Biomedical Engineering, Nanyang Technological University, 62 Nanyang Drive, Singapore - - 2014
Bioprocesses such as production of organic acids or acid hydrolysis of bioresources during biofuel production often suffer limitations due to microbial sensitivity under acidic conditions. Approaches for improving the acid tolerance of these microbes have mainly focused on using metabolic engineering tools. Here, we tried to improve strain acidic tolerance ...
Du Peng P Division of Bioorganic Chemistry, School of Pharmacy, Saarland University, D-66123 Saarbruecken, - - 2014
Selenium compounds play a major role in Biology, where they are often associated with pronounced antioxidant activity or toxicity. Whilst most selenium compounds are not necessarily hazardous, their often selective cytotoxicity is interesting from a biochemical and pharmaceutical perspective. We have synthesized a series of amphiphilic molecules which combine a ...
Wang Yu-Long YL School of Nuclear Science and Technology, Lanzhou University, Lanzhou, 730000, PR China. - - 2014
Three different functional SBA-15 were prepared by a post-grafting method using three iminodiacetic acid derivatives of ethylenediaminetriacetic acid (ED3A), diethylenetriaminetetraacetic acid (DT4A), and 1,2-cyclohexylenedinitrilotriacetic acid (CyD3A), which were used as adsorbents for removal of uranium(vi) from aqueous solution. These materials were characterized by FT-IR, NMR, TEM, nitrogen adsorption/desorption experiments, and ...
Andreeva Valentina A VA Nutritional Epidemiology Research Unit, Sorbonne-Paris-Cité, University of Paris XIII, French Institute of Health and Medical Research, National Institute of Agronomic Research, National Conservatory of Arts and Crafts, Bobigny, - - 2014
Despite growing attention to nutrition and quality of life in cardiovascular disease survivors, the impact of dietary factors according to disease type or to quality of life domain is poorly understood. We investigated the effects of B vitamin and/or n-3 fatty acid supplementation on health-related quality of life among survivors ...
Hao Gengxin G College of Biological Engineering, Jimei University , Xiamen , China - - 2014
Abstract Context: Oysters [Crassostrea plicatula Gmelin (Ostreidae)] are widely used for food in coastal areas. It is reported to have several qualities such as improving sexual and immune function. They has been approved by Chinese Ministry of Health as a functional food. Objective: The effects of five types of oyster ...
Shi Haitao H Key Laboratory of Plant Germplasm Enhancement and Specialty Agriculture, Wuhan Botanical Garden, Chinese Academy of Sciences, Wuhan, 430074, - - 2014
As an important second messenger, calcium is involved in plant cold stress response, including chilling (< 20 (°) C) and freezing (< 0 (°) C). In this study, exogenous application of calcium chloride (CaCl2 ) improved both chilling and freezing stress tolerances, while ethylene glycol-bis-(β-aminoethyl) ether-N, N, N, N-tetraacetic acid ...
Chaufan Gabriela G Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Ciudad Universitaria, Buenos Aires, Argentina. - - 2014
In the present study, the effects on oxidative balance and cellular end points of glyphosate, aminomethylphosphonic acid (AMPA), and a glyphosate formulation (G formulation) were examined in HepG2 cell line, at dilution levels far below agricultural recommendations. Our results show that G formulation had toxic effects while no effects were ...
Ahn Hong Ryul - - 2014
We investigated the effects of an ethanol extract of C. denticulatum (EECD) in a mouse model of glaucoma established by optic nerve crush (ONC), and found that EECD significantly protected against retinal ganglion cell (RGC) death caused by ONC. Furthermore, EECD effectively protected against N-methyl-D-aspartate-induced damage to the rat retinas. ...
Zhang Lili L Guangdong Provincial Key Laboratory of Biotechnology for Plant Development, School of Life Sciences, South China Normal University, Guangzhou, - - 2014
In insects, cholesterol is one of the membrane components in cells and a precursor of ecdysteroid biosynthesis. Because insects lack two key enzymes, squalene synthase and lanosterol synthase, in the cholesterol biosynthesis pathway, they cannot autonomously synthesize cholesterol de novo from simple compounds and therefore have to obtain sterols from ...
Wu Hong H Department of Microbiology and Infection Control, Osaka Medical College, 2-7 Daigaku-machi, Takatsuki, Osaka, 569-8686, Japan, - - 2014
Helicobacter pylori possesses intrabacterial nanotransportation systems (ibNoTSs) for CagA and urease. Both systems are UreI-dependent and urea-independent, and activated by extrabacterial acid. The activation occurs/appears within 15 min after exposure to extrabacterial acid stimulation. Although it has been clarified that VacA is secreted via the type-V secretion machinery, it remains unclear ...
Silva Inês R IR Center for Bioprocess Engineering, Department of Chemical and Biochemical Engineering, Technical University of Denmark, Building 229, 2800, Kongens Lyngby, - - 2014
Rhamnogalacturonan I lyases (RGI lyases) (EC 4.2.2.-) catalyze cleavage of α-1,4 bonds between rhamnose and galacturonic acid in the backbone of pectins by β-elimination. In the present study, targeted improvement of the thermostability of a PL family 11 RGI lyase from Bacillus licheniformis (DSM 13/ATCC14580) was examined by using a ...
Sonntag Frank F DECHEMA Forschungsinstitut, Theodor-Heuss-Allee 25, 60486, Frankfurt, - - 2014
The ethylmalonyl-coenzyme A pathway (EMCP) is a recently discovered pathway present in diverse α-proteobacteria such as the well studied methylotroph Methylobacterium extorquens AM1. Its glyoxylate regeneration function is obligatory during growth on C1 carbon sources like methanol. The EMCP contains special CoA esters, of which dicarboxylic acid derivatives are of ...
Fang Lei - - 2014
By taking advantage of the cytotoxic effect of nitric oxide (NO) and PepT1 for molecule-targeted drug delivery, a series of amino acid/dipeptide diester prodrugs of NO-donating oleanolic acid derivatives were designed and synthesized. Two prodrugs 6a and 8a showed potent cytotoxcity, which is probably due to their high PepT1 affinity ...
Sahar Saurabh S University of California, Irvine, United - - 2014
The circadian clock regulates a wide range of physiological and metabolic processes, and its disruption leads to metabolic disorders such as diabetes and obesity. Accumulating evidence reveals that the circadian clock regulates levels of metabolites that, in turn, may regulate the clock. Here we demonstrate that the circadian clock regulates ...
Whitt James J SAIC-Frederick, Inc., Frederick National Laboratory for Cancer Research , P.O. Box B, Frederick, Maryland 21702, United - - 2014
Coculture of the fungus Fusarium pallidoroseum with the bacterium Saccharopolyspora erythraea was found to produce three new decalin-type tetramic acid analogues related to equisetin. The structures were determined by spectroscopic methods. The absolute configurations were established by circular dichroism spectroscopy and comparing the data with those of equisetin.
Loomans Eva M EM Department of Developmental Psychology, Tilburg University, Tilburg, The Netherlands; Department of Epidemiology, and Health Promotion, Public Health Service of Amsterdam (GGD), Amsterdam, The Netherlands. Electronic address: - - 2014
To prospectively investigate the association between maternal long-chain polyunsaturated fatty acid (LCPUFA) status and ratio during pregnancy and children's risk of problem behavior at 5 years of age. Maternal LCPUFA status in plasma phospholipids during pregnancy (M = 13.3, SD = 3 weeks) was available for 4336 women. Children's behavior ...
Filipiak Kamila K Departamento de Química y Bioquímica, Facultad de Farmacia, Universidad CEU San Pablo, Urbanización Monteprincipe, 28668 Madrid, - - 2014
Gallic acid and anthocyanins are abundant plant food bioactives present in many fruits and vegetables, being especially important in the composition of berries. Gallic acid has been shown to possess cytotoxic properties in several cancer cell lines and to inhibit carcinogenesis in animal models. However, its mechanism of action is ...
Hennebelle Marie M Department of Physiology and Biophysics, University of Sherbrooke, Sherbrooke, Quebec, - - 2014
Chronic stress causes the release of glucocorticoids, which greatly influence cerebral function, especially glutamatergic transmission. These stress-induced changes in neurotransmission could be counteracted by increasing the dietary intake of omega-3 polyunsaturated fatty acids (n-3 PUFAs). Numerous studies have described the capacity of n-3 PUFAs to help protect glutamatergic neurotransmission from ...
Millard Andrew A Division of Microbiology and Infection, Warwick Medical School, University of Warwick, Coventry, CV4 7AL, - - 2014
Biosynthesis of retinoic acid from retinaldehyde (retinal) is catalysed by an aldehyde dehydrogenase (ALDH) and its oxidation by cytochrome P450 enzymes (CYPs). Herein we show by phylogenetic analysis that the ALDHs and CYPs in the retinoic acid pathway in animals are much closer in evolutionary terms to cyanobacterial orthologs than ...
Bolognesi Maria Laura ML Department of Pharmacy and Biotechnology, University of Bologna, Via Belmeloro 6 and, Via Irnerio 4, 40126, Bologna, - - 2014
A series of new lipoic acid derivatives were designed and synthesized as multitarget ligands against Alzheimer's disease (AD). In particular, analogues combining both lipoic acid and cysteine core structures were synthesized. The antioxidant properties of these compounds were evaluated by 1,1-diphenyl-2-picrylhydrazyl (DPPH), 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid (ABTS(•+) ) radical cation scavenging assays ...
Turesson J J Department of Pediatrics, Karolinska Institute, Stockholm, - - 2014
Microinjections of kynurenic acid and kainic acid into the general visceral nucleus (nGV), homologous to the mammalian nucleus tractus solitarius of the medulla, in anesthestized, spontaneously breathing catfish were used to identify central areas and mechanisms controlling resting normoxic heart rate and blood pressure and the cardiovascular responses to hypoxia. ...
Hauser Joachim J Department of Experimental Psychology, University of Regensburg, 93040, Regensburg, - - 2014
The present study investigated the effects of nutritional omega-3 polyunsaturated fatty acids on locomotor activity in spontaneously hypertensive rats (SHRs), which are used as an animal model of attention-deficit/hyperactivity disorder (ADHD). For 6 weeks, two groups of randomly assigned SHRs received food either enriched with or deficient in omega-3 fatty acids ...
Qin Xianhui X Division of Nephrology, Nanfang Hospital, Southern Medical University, Guangzhou, China; Institute of Biomedicine, Anhui Medical University, Hefei, - - 2014
There is a growing amount of data and a continuing controversy over the effect of folic acid supplementation with and without vitamin B6 on revascularization risk. We conducted a meta-analysis based on up-to-date published relevant randomized trials to further examine this issue. Relative risk (RR) was used to measure the ...
Liu Benzhi B School of Environmental Science and Engineering, Yancheng Institute of Technology, Yancheng, Jiangsu Province, 224051, China. Electronic address: - - 2014
Silver nanodendrites were successfully prepared by electrodeposition on the glassy carbon electrode. The effects of synthesis parameters such as concentrations of reagents and applied potentials on the morphology and structure of silver nanodendrites have been investigated. Electrochemical experiments showed that silver nanodendrites electrode had extraordinary electrocatalytic activity toward the dechlorination ...
Chiang Ming-Lun ML 1 Department of Tourism and Hospitality, Kainan University , Taoyuan, Taiwan - - 2014
Abstract Three strains of Vibrio parahaemolyticus (690, BCRC 13023, and BCRC 13025), involved in foodborne outbreaks in Taiwan, were subjected to acid adaptation at pH 5.5 for 90 min. The effects of acid adaptation on the tolerance of V. parahaemolyticus to various environmental stresses, including heat (47°C), cold (4°C and -20°C), ...
Cheng Gui-Juan GJ Lab of Computational Chemistry and Drug Design, Laboratory of Chemical Genomics, Peking University Shenzhen Graduate School , Shenzhen 518055, - - 2014
A combined experimental/computational study on the amino acid ligand-assisted Pd-catalyzed C-H bond activation reveals a mechanism in which the amino acid acts as both a dianionic bidentate ligand and a proton acceptor. This new model explains the effects of amino acids on reactivity and selectivity and unveils the dual roles ...
Wu Dongdong D Department of Chemistry, Brandeis University, 415 South St., Waltham, MA 02454, USA. - - 2014
Here we report the first example of a hydrogelator made of a conjugate of nucleobase-saccharide-amino acids by incorporating l-3-(2-naphthyl)-alanine to the conjugate, which illustrates a facile and effective method for generating bioactive and functional hydrogelators from the basic biological building blocks.
Vlaardingerbroek Hester H Department of Pediatrics, Division of Neonatology, Erasmus MC - Sophia Children's Hospital, c/o Room SP3433, P.O. Box 2060, 3000 CB Rotterdam, The - - 2014
An anabolic state can be achieved upon intravenous amino acid administration during the immediate postnatal phase despite a low energy intake. The optimal dosing of amino acid and energy intake has yet to be established. The aim was to quantify the efficacy of early initiation of parenteral lipids and increased ...
Xu Gang - - 2014
RW-Cb, the first processed product of Cibotium barometz (L.) J. Sm. (Dicksoniaceae) in TCM has been widely used to treat osteoporosis, a major worldwide health problem, influencing more and more people in the word et al. To do research on RW-Cb, one processed product of Cibotium barometz (L.) J. Sm. ...
Perez-Cornago A A Department of Nutrition, Food Science and Physiology, University of Navarra, C/Irunlarrea 1, 31008, Pamplona, - - 2014
The application of metabolomics in nutritional research may be a useful tool to analyse and predict the response to a dietary intervention. The aim of this study was to examine metabolic changes in serum samples following exposure to an energy-restricted diet (-15 % of daily energy requirements) over a period of ...
Yoo Wonbaek W Division of Endocrinology and Metabolism, Department of Internal Medicine, Korea University College of Medicine, Seoul, Republic of Korea; Graduate School of Medicine, Korea University, Seoul, Republic of - - 2014
Free fatty acid-induced lipotoxicity via increased endoplasmic reticulum (ER) stress and hepatocyte apoptosis is a key pathological mechanism of non-alcoholic steatohepatitis. A role of hypoxia inducible factor 1α (HIF-1α), in this process has been suggested, but direct evidence is lacking. Here, we used HepG2 cells as a model to study ...
Kwon Soon-Gu - - 2014
We previously developed a thrombus-induced ischemic pain (TIIP) animal model, which was characterized by chronic bilateral mechanical allodynia without thermal hyperalgesia (TH). On the other hand we had shown that intraplantar injection of acidic saline facilitated ATP-induced pain, which did result in the induction of TH in normal rats. Because ...
Cantarella Maria M Department of Industrial and Information Engineering and Economics, University of l'Aquila, via Giovanni Gronchi n.18-Nucleo industriale di Pile, 67100 L'Aquila, Italy. Electronic address: - - 2014
This study focusses on the reversible/irreversible damage that selected phenolic compounds, released during steam-explosion pretreatment, mandatory for cellulose accessibility, causes on both stability and activity of a commercial cellulase (half-life=173h) during carboxymethyl-cellulose hydrolysis. Long-term experiments performed in continuous stirred UF-membrane bioreactors, operating at steady-state regime, in controlled operational conditions, allowed ...
Sun Yiran Y Beijing National Laboratory for Molecular Sciences, Key Laboratory of Photochemistry, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190 - - 2014
The degradation behaviours of five straight-chain dicarboxylic acids (from ethanedioic acid to hexanedioic acid) were compared in aqueous TiO2 -based photocatalysis. When all other conditions were identical, the degradation rates were found to fluctuate regularly with the parity of the number of carbon atoms. Dicarboxylic acids with an even number ...
Haider Muhammad H MH Cardiff Catalysis Institute, School of Chemistry, Cardiff University, Main Building, Park Place, Cardiff, CF10 3AT (United - - 2014
The effect of ceria and zirconia grafting onto alumina (α and θ-δ phases) as supports for silicotungstic acid for the dehydration of glycerol to acrolein was studied. 30 % Silicotungstic acid (STA) supported on 5 % zirconia/δ,θ-alumina was the best catalyst, producing 85 % selectivity to acrolein at 100 % glycerol conversion, and it ...
Vitale Romina R Drug Discovery & Development, Italian Institute of Technology (IIT), Via Morego 30, 16163 Genova - - 2014
N-Acylethanolamine acid amidase (NAAA) is a cysteine amidase that preferentially hydrolyzes saturated or monounsaturated fatty acid ethanolamides (FAEs), such as palmitoylethanolamide (PEA) and oleoylethanolamide (OEA), which are endogenous agonists of nuclear peroxisome proliferator-activated receptor-α (PPAR-α). Compounds that feature an α-amino-β-lactone ring have been identified as potent and selective NAAA inhibitors ...
Inai Miyuki - - 2014
The effect of antioxidant polyphenols and related phenolic compounds from plants on the reduction of metmyoglobin (MetMb) was investigated. Potent activity in the reduction of MetMb to oxymyoglobin (MbO2), a bright red protein in meat, was observed for three flavonols, kaempferol, myricetin, and quercetin at 300µmol/L against 60 µmol/L of ...
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