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Russo Laura L Department of Biotechnology and Biosciences , University of Milano-Bicocca , Piazza della Scienza 2, Milano 20126 , - - 2014
Different methods for the functionalization of carbonate hydroxyapatite granules with free amine groups by reaction with (3-aminopropyl)triethoxysilane (APTES) have been compared in order to improve the potential for tethering of bioactive molecules to bioceramics. The combined use of tetraethoxyorthosilicate and APTES with acid catalysis resulted in an evident increase in ...
Borreani Giorgio G Department of Agricultural, Forest and Food Sciences (DISAFA), University of Torino, Via Leonardo da Vinci 44, I-10095, Grugliasco, - - 2014
The most important factor that can influence silage quality is the degree of anaerobiosis maintained during conservation. The quality of the plastic film is a key factor, since the permeability of polyethylene to oxygen is too high for silage conservation. The aim of this work was to assess the effects ...
Lee Seung Sik SS Advanced Radiation Technology Institute (ARTI), Korea Atomic Energy Research Institute (KAERI), Jeongeup 580-185, Republic of - - 2014
Anthocyanins are naturally occurring phenolic compounds having broad biological activities including anti-mutagenesis and anti-carcinogenesis. We studied the effects and the degradation mechanisms of the most common type of anthocyanins, cyanidin-3-rutinoside (cya-3-rut), by using gamma ray. Cya-3-rut in methanol (1mg/ml) was exposed to gamma-rays from 1 to 10kGy. We found that ...
Ma Rongna R State Key Laboratory of Analytical Chemistry for Life Science, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210093, P.R. China. - - 2014
A stepwise strategy was developed to synthesize boronic acid functionalized magnetic carbon nanotubes (MCNTs) for highly specific enrichment of glycopeptides. The MCNTs were synthesized by a solvothermal reaction of Fe(3+) loaded on the acid-treated CNTs and modified with 1-pyrenebutanoic acid N-hydroxysuccinimidyl ester (PASE) to bind aminophenylboronic acid (APBA) via an ...
Morrill Louis C LC EaStCHEM, School of Chemistry, University of St Andrews , North Haugh, St Andrews, KY16 9ST, - - 2014
Isothiourea HBTM-2.1 promotes the catalytic asymmetric α-functionalization of 3-alkenoic acids through formal [2 + 2] cycloadditions with N-tosyl aldimines and formal [4 + 2] cycloadditions with either 4-aryltrifluoromethyl enones or N-aryl-N-aroyl diazenes, providing useful synthetic building blocks in good yield and with excellent enantiocontrol (up to >99% ee). Stereodefined products ...
Chen Shih-Yuan SY Hydrotreating Catalysis Team, Research Center for New Fuels and Vehicle Technology, National Institute of Advanced Industrial Science and Technology (AIST), 1-1-1 Higashi, Tsukuba, Ibaraki 305-8565, Japan. Electronic address: - - 2014
Sulfonic acid-functionalized platelet SBA-15 mesoporous silica with an acid capacity of 2.44mmol H(+) g-cat(-1) (shortly termed 15SA-SBA-15-p) was one-pot synthesized by co-condensation method. When applied as solid acid catalyst in synthesis of Jatropha biodiesel fuel (BDF), the 15SA-SBA-15-p catalyst showed higher activity and resistances to water and free fatty acid ...
Guise R R Institute for Biotechnology and Bioengineering, Centre of Genomics and Biotechnology, (IBB/CGB-UTAD), Universidade de Trás-os-Montes e Alto Douro, School of Life Sciences and Environment, Edifício de Enologia, Apartado 1013, 5001-801 Vila Real, Portugal; CQ-VR, Chemistry Research Centre of Vila Real, Chemistry Department, Universidade de Trás-os-Montes e Alto Douro, Apartado 1013, 5000-801 Vila Real, - - 2014
Carboxylmethylcellulose (CMC) is authorised to prevent wine tartaric instability. The effect of CMC structural characteristics on their effectiveness is not well understood. The main purpose of this study was to compare the impact of CMC's with different degrees of substitution and molecular weight, on tartaric stability, tartaric acid, mineral concentration, ...
Zhang Juan J Shanghai Key Laboratory of Bio-Energy Crops, School of Life Sciences, Shanghai University, Shanghai 200444, - - 2014
Alkali-soluble pectin, which has been extracted from Canna edulis Ker, was characterized by single sugar determination and atomic force microscopy (AFM). The results indicated that the amounts of four predominant sugars including arabinose (Ara), glucose (Glc), galactose (Gal) and galacturonic acid (GalA) significantly decreased during the process of mild acid ...
Wang Xiaoming X College of Food Science and Technology, Nanjing Agriculture University , Nanjing 210095, - - 2014
Peroxidation radical formation and the regiospecificity of recombinated lipoxygenase from Anabaena sp. PCC7120 (ana-rLOX) were characterized by using ESR and HPLC-MS. It was found that ana-rLOX oxygenated at the C-13 position of the substrate linoleic acid (LA); at C-13 and C-16 of α-linolenic acid (ALA); at C-9, C-12, and C-15 ...
Shi Y Y 1Department of Horticulture, Zhejiang University, Hangzhou, Zhejiang, - - 2014
The effects of 1-methylcyclopropene (1-MCP) on shelf life, fruit visual quality and nutritional quality were investigated. Netted melons were treated with air (control) and 0.6 µl l(-1) 1-MCP at 25  for 24 h, and then stored at 25  or 10  for 10 days. 1-MCP significantly extended the shelf life, inhibited weight loss ...
Vivijs Bram B Laboratory of Food Microbiology, KU Leuven, Kasteelpark Arenberg 22, 3001 Leuven, Belgium; Leuven Food Science and Nutrition Research Centre (LFoRCe), KU Leuven, Kasteelpark Arenberg 22, 3001 Leuven, Belgium; Department of Microbial and Molecular Systems (M(2)S), Faculty of Bioscience Engineering, KU Leuven, Kasteelpark Arenberg 22, 3001 Leuven, - - 2014
The mechanisms by which Enterobacteriaceae can survive or grow at low pH are of interest because members of this family are increasingly linked to problems of spoilage and foodborne infection related to mildly acidic foods. In this work, we investigated the contribution of the 2,3-butanediol fermentation pathway in coping with ...
Makiguchi Kosuke K Graduate School of Chemical Sciences and Engineering, and Faculty of Engineering, Hokkaido University, Sapporo, 060-8628, Japan. - - 2014
A high enantiomer-selectivity for the polymerization of rac-lactide was achieved using chiral binaphthol-derived monophosphoric acids as organocatalysts. During the polymerization, d-lactide (DLA) preferentially polymerized via kinetic resolution with the maximum selectivity factor (kD/kL) of 28.3. The selective polymerization of DLA was derived from a dual activation, i.e., monomer activation and ...
Liu Yanlong Y College of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, China; Departments of Medicine and Pharmacology and Toxicology, University of Louisville, Louisville, - - 2014
During periods of cellular hypoxia, hepatocytes adapt to consume less oxygen by shifting energy production from mitochondrial fatty acid β-oxidation to glycolysis. One of the earliest responses to pathologic hypoxia is the activation of the hypoxia-inducible factor (HIF). In the present study, we examined whether HIF-1 and HIF-2 were involved ...
Antunes Margarida M MM Department of Chemistry, CICECO, University of Aveiro, Campus de Santiago, 3810-193 Aveiro - - 2014
The acid-catalyzed reaction of 5-(hydroxymethyl)-2-furfural with ethanol is a promising route to produce biofuels or fuel additives within the carbohydrate platform; specifically, this reaction may give 5-ethoxymethylfurfural, 5-(ethoxymethyl)furfural diethylacetal, and/or ethyl levulinate (bioEs). It is shown that sulfonated, partially reduced graphene oxide (S-RGO) exhibits a more superior catalytic performance for ...
Puri Basant K BK Department of Medicine and Department of Imaging, Hammersmith Hospital, Imperial College London, Du Cane Road, London W12 0HS, England, UK. Electronic address: - - 2014
Concerns about growth retardation and unknown effects on long-term brain development with stimulants have prompted interest in polyunsaturated fatty acid supplementation (PUFA) as an alternative treatment. However, randomized controlled trials (RCTs) and meta-analyses of PUFA supplementation in ADHD have shown marginal benefit, and uncertainty exists as to which, if any, ...
Colpo Elisângela E Departamento de Química, Centro de Ciências Naturais e Exatas, Universidade Federal de Santa Maria (UFSM), Santa Maria, RS, - - 2014
To investigate the potential antioxidant effects of Phyllanthus niruri (P. niruri, Euphorbiaceae) tea on healthy subjects. Five non-smoking, male healthy volunteers, 20 to 31 years old, were enrolled. Each subject was treated twice, following a randomized crossover fashion regarding the ingestion of P. niruri infusion (5 g/750 mL) (tea group) ...
Harant-Farrugia Isabelle I Institut des Maladies Métaboliques et Cardiovasculaires, Institut National de la Santé et de la Recherche Médicale (INSERM U1048) and Université Paul Sabatier, I2MC-UPS, 31432, Toulouse Cedex 4, - - 2014
Differential effects of n-3 and n-6 polyunsaturated fatty acids (PUFAs) have been demonstrated on adipose tissue physiology. Facing to the widely recognized beneficial effects of n-3 PUFAs, the n-6 PUFA effects remain controversial. Thus, we further analyzed the linoleic acid (LA) influence on adipocyte functions. To this aim, we treated ...
Wang Yue-Fei YF Department of Tea Science, Zhejiang University, Hangzhou 310058, China; Key Laboratory of Horticultural Plant Growth, Development and Quality Improvement, Ministry of Agriculture, Hangzhou 310058, China; College of Pharmacy, Zhejiang Chinese Medical University, Hangzhou 310053, - - 2014
The conditions for extracting polysaccharides from tea (Camellia sinensis L.) fruit peel (TFPPs) were studied. Three parameters (temperature, time, and liquid/solid ratio) affecting the extraction of TFPP were optimized using response surface methodology (RSM). Under the optimized conditions, the yield of TFPP was predicted to be 4.98%. The physicochemical properties, ...
Karrasch T T Department of Internal Medicine III, Giessen University Hospital, - - 2014
Visfatin represents a new adipokine secreted by visceral adipose tissue and possibly regulating insulin sensitivity. Data on the regulation of visfatin are sparse and contradictory. Our study investigates the regulation of serum visfatin concentrations in healthy and non-diabetic subjects in response to the ingestion of a newly developed oral lipid ...
Zhong R Z - - 2014
Direct inhibitory effects of tannic acid on Haemonchus contortus viability were studied in vitro using the larval migration inhibition (LMI) assay. Sheep white blood cells (WBC) were preincubated with 5 and 50 lg/mL tannic acid or not followed by whole H. contortus antigen (WHA). Cells were harvested at 24 h ...
Alves Carlos Tiago CT IBB-Institute for Biotechnology & Bioengineering, Centre of Biological Engineering, University of Minho, 4710-057 Braga, - - 2014
Aim: To evaluate the antifungal effect of gallic acid, catechin, luteolin and quercetin, phenolic compounds identified from flowers of North Eastern Portugal, against Candida planktonic and biofilm cells. Materials & methods: The MICs were determined in Candida planktonic cells and the effect of phenolic compounds on Candida biofilms was assessed ...
Zhang Zhi-Yu ZY School of Chemical Engineering and Technology, Tianjin University, Tianjin 300072, China; State Key Laboratory of Drug Delivery Technology and Pharmacokinetics, Tianjin Institute of Pharmaceutical Research, Tianjin 300193, - - 2014
A significant number of organic carboxylic acids have been shown to influence the absorption and distribution of drugs mediated by organic anion transporters (OATs). In this study, uptake experiments were performed to assess the inhibitory effects of cinnamic acid, ferulic acid, oleanolic acid, deoxycholic acid, and cynarin on hOAT1, hOAT3, ...
Douša Michal M Zentiva, k.s. Praha, U Kabelovny 130, 102 37 Praha 10, Czech - - 2014
The retention behavior of several series of free α- and ω-amino acids and positional isomers of amino pentanoic acid in the hydrophilic interaction chromatography mode (HILIC) was studied. The study was carried out on three stationary phases followed by post-column derivatization with fluorescence detection in order to describe the retention ...
Baenas Nieves - - 2014
Several biotic elicitors have been used in Brassicaceae species to enhance their phytochemical quality. However, there is no comparison between elicitors under controlled-growth conditions. In order to draw general conclusions about the use of elicitors to enrich ready-to-eat sprouts in health-promoting glucosinolates, the aim of this study was to unveil ...
Sassa Takayuki T Hokkaido University, - - 2014
X-linked adrenoleukodystrophy (X-ALD) is a peroxisomal disorder caused by impaired degradation of very long-chain fatty acids (VLCFAs) due to mutations in the ABCD1 gene responsible for VLCFA transport into peroxisomes. Lorenzo's oil, a 4:1 mixture of glyceryl trioleate and glyceryl trierucate, has been used to reduce the saturated VLCFA level ...
Malik-Wolf Brittany B Division of Forensic Toxicology, Armed Forces Medical Examiner System, Dover, DE, - - 2014
This study examined the potential of abalone β-glucuronidase as a viable and cost effective alternative to current hydrolysis procedures using acid, Helix pomatia β-glucuronidase and Escherichia coli β-glucuronidase. Abalone β-glucuronidase successfully hydrolyzed oxazepam-glucuronide and lorazepam-glucuronide within 5% of the spiked control concentration. Benzodiazepines present in authentic urine specimens were within ...
Keith John M JM Janssen Pharmaceutical Companies of Johnson & Johnson, 3210 Merryfield Row, San Diego, CA 92121, United States. Electronic address: - - 2014
A series of 1-aryl-2-(((6-aryl)pyrimidin-4-yl)amino)ethanols have been found to be competitive inhibitors of fatty acid amide hydrolase (FAAH). One member of this class, JNJ-40413269, was found to have excellent pharmacokinetic properties, demonstrated robust central target engagement, and was efficacious in a rat model of neuropathic pain.
Fowler Alpha A AA - - 2014
Parenterally administered ascorbic acid modulates sepsis-induced inflammation and coagulation in experimental animal models. The objective of this randomized, double-blind, placebo-controlled, phase I trial was to determine the safety of intravenously infused ascorbic acid in patients with severe sepsis. Twenty-four patients with severe sepsis in the medical intensive care unit were ...
Yang Yi - - 2014
The effect of halides on organic contaminant destruction efficiency was compared for UV/H2O2 and UV/S2O82- AOP treatments of saline waters; benzoic acid, 3-cyclohexene-1-carboxylic acid and cyclohexanecarboxylic acid were used as models for aromatic, alkene and alkane constituents of naphthenic acids in oil-field waters. In model freshwater, contaminant degradation was higher ...
Pandurangan Kamalakannan K Department of Pharmacology, Meenakshi Medical College & Research Institute, Meenakshi Academy of Higher Education and Research, Kanchipuram, Pincode - 631 552, India. Electronic address: - - 2014
The aim of the present study was to evaluate the antinociceptive action of certain dimethoxy flavones (DMF, (7,2'-Dimethoxy flavone, 7,3'-Dimethoxy flavone, 7,4'-Dimethoxy flavone and 7,8,-Dimethoxy flavone) and the possible mechanisms involved. The antinociceptive effect of dimethoxy flavones was investigated in mice employing acetic acid-induced abdominal writhings, formalin-induced nociception and hot ...
Angcajas Aileen B AB Department of Applied Biological Chemistry, Faculty of Agriculture, Graduate School of Science and Technology,. Electronic address: - - 2014
Autophagy is the intracellular bulk degradation process to eliminate damaged cellular machinery and to recycle building blocks, and is crucial for cell survival and cell death. Amino acids modulate autophagy in response to nutrient starvation and oxidative stress. We investigated the relevance of reactive oxygen species (ROS) production on the ...
Druart Céline C Metabolism and Nutrition Research Group, Louvain Drug Research Institute, Université catholique de Louvain, Avenue E. Mounier 73, PO box B1.73.11, 1200, Brussels, - - 2014
The aim of this human study was to assess the influence of prebiotic-induced gut microbiota modulation on PUFA-derived bacterial metabolites production. Therefore, we analyzed the circulating fatty acid profile including CLA/CLnA in obese women treated during 3 months with inulin-type fructan prebiotics. In these patients, we had already determined gut microbiota ...
Bianchi Ana Clara AC Departamento de Bioingeniería, Facultad de Ingeniería, Instituto de Ingeniería Química, Julio Herrera y Reissig 565, 11300, Montevideo, - - 2014
Docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) are long-chain polyunsaturated fatty acids (PUFAs) that belong to the omega-3 group. They are essential fatty acids found in phospholipid of cell membranes. There is strong evidence that these nutrients may also favorably modulate many diseases. Primary sources of omega-3 PUFAs in the ...
Escobar Cícero C Departamento de Engenharia Química-Universidade Federal do Rio Grande do Sul Rua Eng. Luis Englert s/n, 90040-040, Porto Alegre, RS, - - 2014
A series of silica xerogels that support Rhodamine B as a template were synthesized using distinct sol-gel routes, namely, acid-catalyzed routes, a base-catalyzed route, acid-catalyzed with base-catalyzed (two steps) hydrolytic routes and a FeCl3 -catalyzed non-hydrolytic route. The extraction methods (thermal, Soxhlet, water washing, and ultrasound) were also evaluated. The ...
Kobylarz Marek J MJ Department of Microbiology and Immunology, Life Sciences Institute, The University of British Columbia, Vancouver, BC V6T 1Z3, - - 2014
L-2,3-diaminopropionic acid (L-Dap) is an amino acid that is a precursor of antibiotics and staphyloferrin B a siderophore produced by Staphylococcus aureus. SbnA and SbnB are encoded by the staphyloferrin B biosynthetic gene cluster and are implicated in L-Dap biosynthesis. We demonstrate here that SbnA uses PLP and substrates O-phospho-L-serine ...
Peters-Wendisch P P Genetics of Prokaryotes, Faculty of Biology and CeBiTec, Bielefeld University, Bielefeld, Germany. Electronic address: - - 2014
The Gram-positive Corynebacterium glutamicum is auxotrophic for biotin. Besides the biotin uptake system BioYMN and the transcriptional regulator BioQ, this bacterium possesses functional enzymes for the last three reactions of biotin synthesis starting from pimeloyl-CoA. Heterologous expression of bioF from the Gram-negative E. coli enabled biotin synthesis from pimelic acid ...
Prasher Parteek P Department of Chemistry, Guru Nanak Dev University, Amritsar 143005, - - 2014
N-1 tosyl indoles carrying amino acid as a part of C-3 substituent are identified with considerable 5-LOX inhibitory activities. On the basis of enzyme inhibitory activities and logP, it is found that these compounds are more suitable to use as ester prodrugs. In addition to the significant Ka and Ki ...
Toquero Cristina C Department of Chemical Engineering and Environmental Technology, University of Valladolid, Dr. Mergelina s/n, 47011 Valladolid, - - 2014
Pretreatment is essential in the production of alcohol from lignocellulosic material. In order to increase enzymatic sugar release and bioethanol production, thermal, dilute acid, dilute basic and alkaline peroxide pretreatments were applied to wheat straw. Compositional changes in pretreated solid fractions and sugars and possible inhibitory compounds released in liquid ...
Zeng Li-Mei LM State Key Laboratory of Agricultural Microbiology and Key Laboratory of Plant Pathology of Hubei Province, Huazhong Agricultural University, Wuhan 430070, - - 2014
Coniothyrium minitans (Cm) is a mycoparasite of the phytopathogenic fungus Sclerotinia sclerotiorum (Ss). Ss produces a virulence factor oxalic acid (OA) which is toxic to plants and also to Cm, and Cm detoxifies OA by degradation. In this study, two oxalate decarboxylase genes, Cmoxdc1 and Cmoxdc2, were cloned from Cm ...
Buerth Christoph C Institut für Molekulare Mykologie, Heinrich-Heine-Universität, Universitätsstr. 1/26.12, 40225 Düsseldorf, - - 2014
CalB of Pseudozyma aphidis (formerly named Candida antarctica) is one of the most widely applied enzymes in industrial biocatalysis. Here, we describe a protein with 66 % sequence identity to CalB, designated Ustilago maydis lipase 2 (Uml2), which was identified as the product of gene um01422 of the corn smut fungus ...
Tuley Alfred A Department of Chemistry, Texas A&M University, College Station, TX 77843, USA. - - 2014
Thirteen novel non-canonical amino acids were synthesized and tested for suppression of an amber codon using a mutant pyrrolysyl-tRNA synthetase-tRNA pair. Suppression was observed with varied efficiencies. One non-canonical amino acid in particular contains an azide that can be applied for site-selective protein labeling.
Debrassi Aline A Laboratory of Organic Chemistry, Wageningen University , Dreijenplein 8, 6703 HB Wageningen, The - - 2014
Porous aluminum oxide (PAO), a nanostructured support for, among others, culturing microorganisms, was chemically modified in order to attach biomolecules that can selectively interact with target bacteria. We present the first comprehensive study of monolayer-modified PAO using conditions that are relevant to microbial growth with a range of functional groups ...
Derényi I I ELTE-HAS "Lendulet" Biophysics Research Group, Department of Biological Physics, Eötvös Loránd University, Budapest H-1111, - - 2014
Division of a millimeter-sized and compartmentalized fatty acid droplet is triggered by a chemical pH clock reaction operating on the ten-second time scale. The autonomous pH change inside the compartment translates into the deprotonation of the fatty acid molecules, leading to a negative interfacial tension at the water-oil interface inside ...
Larsson Jenny J IFM Biology, Linköping University, SE-581 83 Linköping, - - 2014
The gustatory responsiveness of four adult spider monkeys to the 20 proteinogenic amino acids was assessed in two-bottle preference tests of brief duration (1min). We found that Ateles geoffroyi responded with significant preferences for seven amino acids (glycine, L-proline, L-alanine, L-serine, L-glutamic acid, L-aspartic acid, and L-lysine) when presented at ...
Huang Wen-Cheng WC Department of Human Development and Family Studies, National Taiwan Normal University, Taipei, - - 2014
Δ7-eicosatrienoic acid (Δ7-ETrA; Δ7,11,14-20:3), an elongation metabolite of pinolenic acid (PNA; Δ5,9,12-18:3), is a rare polyunsaturated fatty acid (PUFA) originally from pine seeds. Incorporation of PNA and Δ7-ETrA into murine macrophages inhibited lipopolysaccharide (LPS)-stimulated prostaglandin E2 (PGE2) production. Due to the lack of availability of the naturally-occurring fatty acid, we ...
Kaminskyy Danylo D Department of Pharmaceutical, Organic and Bioorganic Chemistry, Danylo Halytsky Lviv National Medical University, Pekarska 69, Lviv 79010, - - 2014
A series of new isothiocoumarin-3-carboxylic acids derivatives had been obtained based on the 5-arylidenerhodanines hydrolysis. Anticancer activity screening allowed identification of 7,8-dimethoxy-1-oxo-1H-isothiochromene-3-carboxylic acid (4-phenylthiazol-2-yl)-amide (30) with the highest level of antimitotic activity (GI50NCI-H322M/NSC Lung Cancer = 1.28 μM). Evaluation of the antitrypanosomal activity against Trypanosoma brucei brucei showed that investigated compounds did not ...
Yan Daojiang D National Key Laboratory of Biochemical Engineering, Institute of Process Engineering, Chinese Academy of Sciences, P.O. Box 353, Beijing 100190, PR China; University of Chinese Academy of Sciences, Beijing 100049, PR - - 2014
Succinic acid is an important precursor for the synthesis of high-value-added products. Saccharomyces cerevisiae is a suitable platform for succinic acid production because of its high tolerance towards acidity. In this study, a modified pathway for succinate production was established and investigated in S. cerevisiae. The engineered strain could produce ...
Shao Ping P Department of Food Science and Technology, Zhejiang University of Technology, Zhejiang Hangzhou 310014, PR - - 2014
Ulva fasciata belonging to the family Ulvaceae, commonly known as 'sea lettuce', is an abundantly growing green seaweed in coastal seashore of South China. Three different molecular weight sulfated polysaccharides (UFP1, UFP2 and UFP3) were extracted and separated from Ulva fasciata by hot water extraction and ultrafiltration. The three native ...
Haggarty Paul P Rowett Institute of Nutrition & Health, University of Aberdeen, Aberdeen, Scotland, - - 2014
The aim of this review is to summarize recent evidence on the importance of individual long chain polyunsaturated fatty acid (LCPUFA) to the developing fetus and the maternal dietary requirement for these. Large-scale randomized controlled trials and innovative genetic and stable isotope studies are providing new insights in this field. ...
Felker Dana D University of California, Berkeley, Morgan Hall, Berkeley, CA 94720-3104, - - 2014
Valproic acid is approved for treatment of seizures and manic episodes of bipolar disorder, and continues to be one of the most commonly prescribed antiepileptic drugs in the world. Hepatotoxicity is a rare but serious side effect resulting from its use, particularly in young patients. This adverse effect does not ...
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