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Yang Xue X Xinjiang Institute of Ecology and Geography, Chinese Academy of Sciences, Urumqi, Xinjiang 830011, China; School of Municipal and Environmental Engineering, Harbin Institute of Technology, Harbin 150090, - - 2014
This study adopted rapid alkaline treatment at pH 12 to hydrolyze 66% of total chemical oxygen demands. Then the hydrolyzed liquor was fermented in a continuous-flow stirred reactor to produce volatile fatty acids (VFAs) at 8-h hydraulic retention time and at 35°C. The maximum VFA productivity reached 365mg VFAsg(-1) volatile ...
Perez Adrián A AA Consejo Nacional de Investigaciones Científicas y Técnicas de la República Argentina, Argentina; Grupo de Biocoloides, Instituto de Tecnología de Alimentos, Universidad Nacional del Litoral, 1 de mayo 3250, 3000 Santa Fe, - - 2014
The aim of this work was to obtain heat-induced β-lactoglobulin (BLG) aggregates in order to test them as carriers of a model polyunsaturated fatty acid (PUFA), linoleic acid (LA). BLG aggregates were obtained at 85°C by varying the heating time (0-60min) and pH of protein dispersion (6.5-7.5). Aggregates were characterised ...
Ralston J C JC Department of Human Health and Nutritional Sciences, University of Guelph, Guelph, Ontario, - - 2014
Background:Stearoyl-CoA desaturase-1 (SCD1) is rate-limiting for the conversion of saturated fatty acids palmitate (16:0) and stearate (18:0) to monounsaturated fatty acids palmitoleate (16:1n7) and oleate (18:1n9), respectively. Given that reduced SCD1 activity is associated with improved insulin sensitivity and decreased body weight, there is considerable interest to elucidate the role ...
Lin Yuheng Y College of Engineering, University of Georgia, Athens, GA 30602, - - 2014
cis,cis-Muconic acid (MA) and salicylic acid (SA) are naturally-occurring organic acids having great commercial value. MA is a potential platform chemical for the manufacture of several widely-used consumer plastics; while SA is mainly used for producing pharmaceuticals (for example, aspirin and lamivudine) and skincare and haircare products. At present, MA ...
Logan Sreemathi S University of Oklahoma HSC, United - - 2014
Autosomal dominant Stargardt-like macular dystrophy (STGD3) in humans results from mutations in Elongation of Very Long chain fatty acids like-4 (ELOVL4), which leads to vision loss in young adults. ELOVL4 is an integral endoplasmic reticulum (ER) protein that mediates the elongation of very long chain (VLC) fatty acids. Mutations in ...
Chan S S M SS Department of Medicine, Norwich Medical School University of East Anglia, Norwich, UK; Norfolk & Norwich University Hospitals NHS Trust, Norwich, - - 2014
There are plausible mechanisms for how dietary docosahexaenoic acid (DHA), an n-3 polyunsaturated fatty acid, could prevent Crohn's disease (CD). To conduct a prospective study to investigate the association between increased intake of DHA and risk of CD. Overall, 229 702 participants were recruited from nine European centres between 1991 and ...
Santos Samantha Christine SC Department of Hydraulic and Sanitation, University of São Paulo, Av. Trabalhador Sãocarlense, 400, Centro, CEP 13566-590, São Carlos, SP, - - 2014
This study aimed to evaluate the effect of high organic loading rates (OLR) (60.0-480.00kgCODm(-3)d(-1)) on biohydrogen production at 55°C, from sugarcane stillage for 15,000 and 20,000mgCODL(-1), in two anaerobic fluidized bed reactors (AFBR1 and AFBR2). It was obtained, for H2 yield and content, a decreasing trend by increasing the OLR. ...
Kamata Shotaro S Department of Biochemistry, Keio University Graduate School of Pharmaceutical Sciences, Tokyo, - - 2014
Dietary deprivation of essential amino acids (EAAs) in mammals is known to cause reductions in food intake and body weight. The aim of this study was to determine whether and how mice respond to deprivation of individual EAA species. Dietary deprivation of any single EAA (not non-EAA) in mice led ...
Li Huiling H State Key Laboratory of Pulp and Paper Engineering, South China University of Technology, Guangzhou 510640, - - 2014
Selectively catalytic hydrothermal pretreatment of corncob into xylose and furfural has been developed in this work using solid acid catalyst (SO4(2-)/TiO2-ZrO2/La(3+)). The effects of corncob-to-water ratio, reaction temperature and residence time on the performance of catalytic hydrothermal pretreatment were investigated. Results showed that the solid residues contained mainly lignin and ...
Ishola Mofoluwake M MM Swedish Centre for Resource Recovery, University of Borås, Sweden; Department of Chemical and Polymer Engineering, Lagos State University, Nigeria. Electronic address: - - 2014
Oil palm empty fruit bunches (OPEFB), a lignocellulosic residue of palm oil industries was examined for ethanol production. Milled OPEFB exposed to simultaneous saccharification and fermentation (SSF) with enzymes and Saccharomyces cerevisiae resulted just in 14.5% ethanol yield compared to the theoretical yield. Therefore, chemical pretreatment with phosphoric acid, a ...
Cortés-Tolalpa Larisa - - 2014
Efficient production of shikimic acid (SA) in Escherichia coli has been achieved by modifying key genes of the central carbon metabolism and SA pathway, resulting in overproducing strains grown in batch- or fed-batch-fermentor cultures using a complex broth including glucose and yeast extract (YE). In this study, we performed a ...
Shkundina Irina I Institutes of Molecular Genetics of the Russian Academy of Sciences, Moscow, - - 2014
Microcin B (McB) is a ribosomally-synthesized antibacterial peptide. It contains up to nine oxazole and thiazole heterocycles that are introduced post-translationally and are required for activity. McB inhibits the DNA gyrase, a validated drug target. Previous structure-activity analyses indicated that two fused heterocycles located in the central part of McB ...
Venturini Chiara - - 2014
The role of the alkyl chain length and of the headgroup on the thermal behavior of mixtures of ASC8 (ascorbyl-octanoate) and ASC16 (ascorbyl-hexadecanoate) was investigated through differential scanning calorimetry, small and wide angle X-ray scattering and Fourier transform infrared spectroscopy experiments. The formation of two eutectics and of a peritectic ...
Saravanamurugan Shunmugavel S Centre for Catalysis and Sustainable Chemistry, Department of Chemistry, Technical University of Denmark, DK-2800 Kgs. Lyngby (Denmark), Fax: - - 2014
Ionic liquids (ILs) comprised of ammonium cations and anions of naturally occurring amino acids containing an additional amine group (e.g., lysine, histidine, asparagine, and glutamine) were examined as high-capacity absorbents for CO2 . An absorption capacity of 2.1 mol CO2 per mol of IL (3.5 mol CO2 per kg IL, 13.1 wt % CO2 ...
Liang Rongcai R School of Pharmacy, Yantai University, No. 32 Qingquan Road, 264005, Yantai, Shandong Province, - - 2014
To prepare acylated exenatide analogues and investigate their biological properties for guiding the development of PLGA formulations of exenatide. The acylated exenatide analogues were prepared by reaction with glycolic acid (GA), one constitutional unit of PLGA, and characterized by HPLC-MS/MS and Circular Dichroism (CD). The pharmacokinetic properties and anti-diabetic activities ...
Dorado J J Animal Reproduction Group, Department of Medicine and Animal Surgery, Faculty of Veterinary Medicine, University of Cordoba, 14071 Córdoba, Spain. Electronic address: - - 2014
The main aim of this study was to evaluate the efficacy of two commercially available liquid stallion semen extenders for the preservation of Andalusian donkey semen at 5°C for up to 72h, and to evaluate the effect of amino acid addition on sperm quality of cooled donkey semen. In addition, ...
Mali Sachitanand M - - 2014
Thioacids are recently gaining momentum due to their versatile reactivity. The reactivity of thioacids has been widely explored in the selective amide/peptide bond formation. Thioacids are generally synthesized from the reaction between activated carboxylic acids such as acid chlorides, active esters etc. and Na2S, H2S, or NaSH. We sought to ...
Jung Jae Yoon JY Department of Dermatology, Seoul National University Hospital, Seoul, - - 2014
This study was undertaken to evaluate the clinical efficacy, safety, and histological changes induced by dietary omega-3 fatty acid and γ-linoleic acid in acne vulgaris. A 10-week, randomised, controlled parallel dietary intervention study was performed in 45 participants with mild to moderate acne, which were allocated to either an omega-3 ...
Peterson Ryan M RM Division of Pharmaceutical Sciences, University of Wisconsin-Madison, Madison, WI 53705, - - 2014
Platensimycin (PTM) and platencin (PTN) are potent inhibitors of bacterial fatty acid synthases and have emerged as promising antibacterial drug leads. We previously characterized the PTM and PTN biosynthetic machineries in the Streptomyces platensis producers. We now identify two mechanisms for PTM and PTN resistance in the S. platensis producers-the ...
Bhavsar Satyendra P SP Ontario Ministry of the Environment, Toronto, ON M9P 3V6, Canada; University of Toronto, Toronto, ON M5S 3E8, Canada. Electronic address: - - 2014
Consumption of fish is considered a part of a healthy diet; however, health risks from fish consumption exist due to potential exposure to various contaminants accumulated in fish. Cooking fish can reduce exposure to many organic chemicals in fish. Similar results have been presented for low levels of perfluoroalkyl and ...
Landolt Peter J - - 2014
Research to discover and develop attractants for the codling moth, Cydia pomonella L., has involved identification of the chemicals eliciting moth orientation to conspecific female moths, host fruits, fermented baits, and species of microbes. Pear ester, acetic acid, and N-butyl sulfide are among those chemicals reported to attract or enhance ...
Li Min M State Key Laboratory of Agricultural Microbiology, Life Science and Technology College, Huazhong Agricultural University, Number 1 Shizishan Street, Hongshan District,, Wuhan, Hubei, 430070, - - 2014
The effects of the addition of short-chain fatty acids and lower alcohols on the production of natamycin from Streptomyces natalensis F4-245 was investigated, and propanol was found to be the most effective additive. Under the optimal condition of propanol addition, the maximal natamycin titer reached 10.38 g/l, which was 17 % higher ...
Zhang Zilian Z State Key Laboratory of Marine Environmental Science, Institute of Marine Microbes and Ecospheres, Xiamen University, Xiamen, 361102, People's Republic of China, - - 2014
Exopolysaccharide (EPS) is produced by many marine bacteria and is important for cell aggregation in the ocean. D-amino acids are important components in bacteria and are recently recognized as signal molecules for regulation of bacterial growth. In this study, the effects of D-amino acids on EPS production, cell aggregation, and ...
Wase Nishikant - - 2014
Nitrogen starvation induces a global stress response in microalgae that results in the accumulation of lipids as a potential source of biofuel. Using GC-MS based metabolite and iTRAQ labeled protein profiling, we examined and correlated the metabolic and proteomic response of Chlamydomonas reinhardtii under nitrogen stress. Key amino acids and ...
Kajimoto Masaki M Seattle Children's Research - - 2014
Extracorporeal membrane oxygenation (ECMO) is frequently used in infants with postoperative cardiopulmonary failure. ECMO also suppresses circulating triiodothyronine (T3) levels and modifies myocardial metabolism. We assessed the hypothesis that T3 supplementation reverses ECMO induced metabolic abnormalities in the immature heart. Twenty-two male Yorkshire pigs (age 25-38 days) with ECMO received ...
Armentrout Peter B - - 2014
Metal cation-amino acid interactions are key components controlling the secondary structure and biological function of proteins, enzymes, and macromolecular complexes comprising these species. Determination of pairwise interactions of alkali metal cations with amino acids provides a thermodynamic vocabulary that begins to quantify these fundamental processes. In the present work, we ...
Min Keun Young KY Division of Animal Life Science, Konkuk University, Seoul 143-701, - - 2014
Citrus fruit (Citrus unshiu) peels were extracted with hot water and then acid-hydrolyzed using hydrochloric acid. Antimicrobial activities of acid-hydrolyzed Citrus unshiu peel extract were evaluated against pathogenic bacteria, including Bacillus cereus, Staphylococcus aureus, and Listeria monocytogenes. Antilisterial effect was also determined by adding extracts at 1, 2, and 4% ...
Stocks S E SE Department of Animal Science, Michigan State University, East Lansing - - 2014
Propionic acid is more hypophagic for cows with elevated hepatic acetyl coenzyme A (CoA) concentration in the postpartum period. The objective of this experiment was to evaluate the interaction of hepatic acetyl CoA concentration, which is elevated by intravenous lipid infusion, and intraruminal propionic acid infusion on feed intake and ...
Esposito G G University of Pretoria, Faculty of Veterinary Sciences, Department of Production Animal Studies, 0110, Onderstepoort, South - - 2014
The effect of season of the year associated with changes in feeding and management system (pasture-based vs. confinement) on milk and cheese fatty acid profile and on sensory properties of Caciocavallo cheese was evaluated on 3 mountain dairy farms. Each farm used a pasture-based feeding system from April to June ...
Porrini Lucía L Instituto de Biología Molecular y Celular de Rosario (IBR), Consejo Nacional de Investigaciones Científicas y Técnicas, Rosario, Argentina; Departamento de Microbiología Facultad de Ciencias Bioquímicas y Farmacéuticas, Universidad Nacional de Rosario. Ocampo y Esmeralda, Rosario, - - 2014
Bacillus subtilis responds to a sudden decrease in temperature by transiently inducing the expression of the des gene encoding for a lipid desaturase, Δ5-Des, which introduces a double bond into the acyl chain of preexisting membrane phospholipids. This Δ5-Des-mediated membrane remodeling is controlled by the cold-sensor DesK. After cooling, DesK ...
Zhao Tingting T Department of Food and Nutrition, Korea University, Seoul 136-703, Republic of Korea; Department of Public Health Sciences, Graduate School, Korea University, Seoul 136-703, Republic of - - 2014
n-3 Polyunsaturated fatty acids (n-3 PUFA)-enriched phosphatidylcholine (PC) was successfully produced with fatty acid from fish oil and PC from soybean by immobilized phospholipase A1-catalyzed acidolysis. Detailed studies of immobilization were carried out, and Lewatit VP OC 1600 was selected as a carrier for preparation of immobilized phospholipase A1, which ...
Xu Jian J The Key Laboratory of Industrial Biotechnology, Ministry of Education, School of Biotechnology, Jiangnan University, 1800 Lihu Road, Wuxi, 214122, - - 2014
In order to solve the problem of extraction wastewater pollution in citric acid industry, an integrated citric acid-methane fermentation process is proposed in this study. Extraction wastewater was treated by mesophilic anaerobic digestion and then used to make mash for the next batch of citric acid fermentation. The recycling process ...
Demetriades Constantinos C German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany. Electronic address: - - 2014
TOR complex 1 (TORC1) is a potent anabolic regulator of cellular growth and metabolism. When cells have sufficient amino acids, TORC1 is active due to its lysosomal localization mediated via the Rag GTPases. Upon amino acid removal, the Rag GTPases release TORC1, causing it to become cytoplasmic and inactive. We ...
Radočaj Olga O Faculty of Technology, Univ. of Novi Sad, Bulevar cara Lazara 1, 21000, Novi Sad, - - 2014
A mixture, simplex centroid, 2 components experimental design was used to evaluate the addition of hemp seed oil press-cake and decaffeinated green tea leaves, as functional ingredients to assess nutritional characteristics and antioxidant properties of gluten-free crackers. All samples with added hemp flour had much better nutritional qualities than the ...
Jin Dong D Department of Chemistry, Brown University, Providence, RI 02912 - - 2014
The catalytic conversion of carbon dioxide and olefins into acrylates has been a long standing target, because society attempts to synthesize commodity chemicals in a more economical and sustainable fashion. Although nickel complexes have been known to successfully couple CO2 and ethylene for decades, a key β-hydride elimination step has ...
Li Yao Y Department of Chemistry, University of Pittsburgh, 219 Parkman Avenue, Pittsburgh, PA 15260, USA. - - 2014
A series of acid-cleavable ester-type protecting groups, with acid-sensitivity profiles parallel to those of 2-naphthylmethyl (NAP) or p-methoxybenzyl (PMB) ether, were designed and TFA in toluene was identified as a technically simple and effective deblocking cocktail for their global removal in the context of oligosaccharide synthesis.
Cheon Hyae Gyeong - - 2014
Excessive saturated fatty acids have been considered to be one of major contributing factors for the dysfunction of skeletal muscle cells as well as pancreatic beta cells, leading to the pathogenesis of type 2 diabetes. PA induced cell death in a dose dependent manner up to 1.5 mM, but AA ...
Ostermann Carola - - 2014
Backround Chlamydia psittaci (Cp) is a respiratory pathogen capable of inducing acute pulmonary zoonotic disease (psittacosis) or persistent infection. To elucidate the pathogenesis of this infection, a translational large animal model was recently introduced by our group. This study aimed at quantifying and differentiating pulmonary dysfunction and acid base imbalances ...
Glencross Brett D BD CSIRO Food Futures Flagship, CSIRO Marine and Atmospheric Research, GPO Box 2583, Brisbane, QLD, 4001, Australia, - - 2014
A study with varying dietary inclusion levels (1, 5, 10, 15 and 20 g kg(-1)) of docosahexaenoic acid (DHA; 22:6n-3) was conducted with post-smolt (111 ± 2.6 g; mean ± S.) Atlantic salmon (Salmo salar) over a 9-week period. In addition to the series of DHA inclusion levels, the study included further diets that had DHA at ...
Arunima Sakunthala S Department of Biochemistry, University of Kerala, Thiruvananthapuram-695581, - - 2014
The present study was carried out to evaluate the effects of virgin coconut oil (VCO) compared with copra oil, olive oil and sunflower-seed oil on the synthesis and oxidation of fatty acids and the molecular regulation of fatty acid metabolism in normal rats. Male Sprague-Dawley rats were fed the test ...
Magnusson Marie M MACRO - the Centre for Macroalgal Resources and Biotechnology, and School of Marine & Tropical Biology, James Cook University, Townsville, Queensland, 4811, Australia, - - 2014
Biomass productivity was quantified for the marine macroalga Derbesia tenuissima cultivated outdoors at seven stocking densities from 0.25 to 8 g L(-1) for 5 weeks. Total lipids and fatty acid quantity and quality was measured from samples that were freeze-dried, dried by oven (75 °C), food dehydrator (60 °C), or outdoor in the sun (40 °C) ...
Zhao Xu X School of Environmental Science and Engineering, Tianjin University, Tianjin 300072, - - 2014
A Box-Behnken design of response surface method was used to optimize acetic acid-catalyzed hydrothermal pretreatment of corn stover, in respect to acid concentration (0.05-0.25%), treatment time (5-15min) and reaction temperature (180-210°C). Acidogenic fermentations with different initial pH and hydrolyzates were also measured to evaluate the optimal pretreatment conditions for maximizing ...
He Yu-Cai YC Laboratory of Biochemical Engineering, College of Pharmaceutical Engineering and Life Sciences, Changzhou University, Changzhou, 213164, China, - - 2014
Brevibacterium sp. CCZU12-1 with high nitrilase activity could effectively hydrolyze benzoyl cyanide into benzoylformic acid. After the culture optimization, the preferred carbon sources, nitrogen sources, and inducer were glucose (10 g/L), a composite of peptone (10 g/L) plus yeast extract (2.5 g/L), and ε-caprolactam (2.0 mM), respectively. After the reaction optimization, the optimum reaction ...
Janesko Benjamin G BG Texas Christian University, Fort Worth, TX 76129, USA. - - 2014
This work presents a computational mechanistic study of the acid-catalyzed hydrolysis of lignin β-O-4 linkages in ionic liquid solvents. Model compound 2-hydroyxyethyl phenyl ether undergoes dehydration to vinyl phenyl ether followed by hydrolysis to phenol and "Hibbert's ketones". Larger model compound α-hydroxy-phenethyl phenyl ether illustrates an E1 dehydration mechanism involving ...
Kapras Vojtěch V Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic , Flemingovo nam. 2, 166 10, Prague 6, Czech - - 2014
Nonproteinogenic amino acids are prepared by an unprecedented domino aza-Michael addition-1,3-dipolar cycloaddition, leading to enantiopure highly substituted pyrrolidinopyrazolines. Nonaflyl azide serves as highly effective diazo transfer reagent, forming the link between the conjugate addition and cycloaddition steps. The resulting pyrrolidinopyrazolines can be rapidly transformed to either α,β,γ-triamino acids or 3,4-methano-β-prolines. ...
Ruhanen Hanna H Minerva Foundation Institute for Medical Research, - - 2014
The I148M substitution in PNPLA3 (PNPLA3(I148M)) determines a genetic form of non-alcoholic fatty liver disease. To elucidate the mode of PNPLA3 action in human hepatocytes, we studied effects of wild-type PNPLA3 (PNPLA3(WT)) and PNPLA3(I148M) on HuH7 cell lipidome after [(13)C]glycerol labelling, cellular turnover of [D17]oleic acid in triacylglycerols (TAGs), and ...
Chen Pan P School of Pharmaceutical Sciences, Sun Yat-sen - - 2014
Oleanolic acid (OA) is a natural triterpenoid and has been demonstrated to protect against varieties of hepatotoxicants. However recently, OA at high doses was reported to produce apparent cholestasis in mice. In this study, we characterized the protective effect of OA at low doses against lithocholic acid (LCA)-induced cholestasis in ...
Vasi Ana-Maria AM "Gheorghe Asachi" Technical University of Iasi, Faculty of Chemical Engineering and Environmental Protection, 73 Prof. dr. docent Dimitrie Mangeron Street, 700050 Iasi, - - 2014
Functionalized hyaluronic acid (HA) derivatives were obtained by ring opening mechanism of maleic anhydride (MA). FTIR and H(1) NMR spectroscopy were used to confirm the chemical linkage of MA on the hyaluronic acid chains. Thermal analysis (TG-DTG and DSC) and GPC data for the new products revealed the formation of ...
Greetham D D School of Biosciences, University of Nottingham, Loughborough, Leicestershire, LE12 5RD, UK, - - 2014
Fermentation of sugars released from lignocellulosic biomass (LCMs) is a sustainable option for the production of bioethanol. LCMs release fermentable hexose sugars and the currently non-fermentable pentose sugars; ethanol yield from lignocellulosic residues is dependent on the efficient conversion of available sugars to ethanol, a side-product of the process is ...
Andrewartha Sarah J SJ Developmental and Integrative Biology, Department of Biological Sciences, University of North Texas, 1155 Union Circle #305220, Denton, Texas 76203, - - 2014
The regulation of blood acid-base balance and hematology in day 15 chicken embryos in response to partial water submersion (with egg's air cell in air) and complete submersion producing severe intrinsic hypercapnic hypoxia and recovery in air was studied. The acid-base disturbance during submersion was characterized by initial rapid respiratory ...
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