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Delattin Nicolas N Centre of Microbial and Plant Genetics, CMPG, KU Leuven, Kasteelpark Arenberg 20, box 2460, 3001 Leuven, - - 2014
We performed a structure-activity relationship study of the antibiofilm plant-derived decapeptide OSIP108. Introduction of positively charged amino acids R, H and K resulted in up to 5-fold increased antibiofilm activity against Candida albicans compared to native OSIP108, whereas substitution of R9 resulted in complete abolishment of its antibiofilm activity. By ...
Tateno Kotaro K Department of Chemistry, Faculty of Science, Tokyo University of Science , 1-3 Kagurazaka, Shinjuku-ku, Tokyo 162-8601, - - 2014
Acid-responsive fluorescent compounds were prepared by introducing a nitrophenyl group to L-shaped pentacycles with a pyrrolo[1,2-a][1,8]naphthylidine backbone. These compounds show almost no fluorescence under neutral conditions, but emit green to orange fluorescence upon addition of trifluoroacetic acid. Acid titration experiments and NMR spectroscopy, plus DFT calculations, show that formation of ...
Tzeng Yu-Zan - - 2014
Trans fatty acids (TFAs) create deleterious effects, thus their existence in human is a great health concern. TFAs can be obtained through diet, or they can be formed endogenously by radical induced cis to trans isomerization. The mechanism of isomerization of fatty acid catalyzed by radicals including nitrogen dioxide (NO2(.)), ...
Moon Morgan L ML Division of Nutritional Sciences, University of Illinois, Urbana IL, - - 2014
Excess fat in the diet can impact neuropsychiatric functions by negatively affecting cognition, mood and anxiety. We sought to show that the free fatty acid (FFA), palmitic acid, can cause adverse biobehaviors in mice that last beyond an acute elevation in plasma FFAs. Mice were administered palmitic acid or vehicle ...
Chhetri Ravi Kumar RK Department of Environmental Engineering, Technical University of Denmark, Bygningstorvet, Building 115, 2800 Kgs. Lyngby, - - 2014
We investigated the possibility of applying performic acid (PFA) and peracetic acid (PAA) for disinfection of combined sewer overflow (CSO) in existing CSO management infrastructures. The disinfection power of PFA and PAA towards Escherichia coli (E. coli) and Enterococcus was studied in batch-scale and pre-field experiments. In the batch-scale experiment, ...
Fradinho J C JC REQUIMTE/CQFB, Chemistry Dpt., FCT, Universidade Nova de Lisboa, 2829-516 Caparica, - - 2014
This work studied the effect of the substrate feeding composition on the polyhydroxyalkanoate (PHA) accumulation capacity of an acetate enriched photosynthetic mixed culture (PMC). From the six tested organic acids-malate, citrate, lactate, acetate, propionate and butyrate-only the three volatile fatty acids (VFAs) enabled PHA production, with acetate and butyrate leading ...
Alsufyani Taghreed T Friedrich Schiller University Jena, Institute for Inorganic and Analytical Chemistry, Lessingstr. 8, Jena 07743, - - 2014
Lipoxygenase/hydroperoxide lyase mediated transformations convert polyunsaturated fatty acids into various oxylipins. First, lipoxygenases catalyze fatty acid oxidation to fatty acid hydroperoxides. Subsequently, breakdown reactions result in a wide array of metabolites with multiple physiological and ecological functions. These fatty acid transformations are highly diverse in marine algae and play a ...
Tao Li L Department of Pharmacology, College of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210023, - - 2014
Integrated research of herbs and formulas characterized by functions of promoting blood circulation and removing blood stasis is one of the most active fields in traditional Chinese medicine. This paper strives to demonstrate the roles of a homologous series of phenolcarboxylic acids from these medicinal herbs in cancer treatment via ...
Sahu Bidya Dhar BD Medicinal Chemistry & Pharmacology Division, CSIR-Indian Institute of Chemical Technology (IICT), Hyderabad, 500 007, - - 2014
Carnosic acid is a well-known antioxidant. Recently, it has been identified as modulator of nuclear factor erythroid 2-related factor 2 (Nrf2). The effect of carnosic acid in the context of cardiovascular disorders has not been studied. In the present study, we investigated the beneficial effect and the underlying cardioprotective mechanism ...
Diwakar Ganesh G Analytical Sciences, Research & Development, Amway Corporation, 7575 Fulton St East, Ada, MI 49355, USA. Electronic address: - - 2014
In recent years, dietary fatty acids have been extensively evaluated for nutritional as well as cosmetic benefits. Among the dietary fats, the omega-3 (ω3) and omega-6 (ω6) forms of polyunsaturated fatty acids (PUFAs) have been found to exhibit many biological functions in the skin such as prevention of transepidermal water ...
Pal Priyanka D PD Department of Biophysics, University Of Mumbai, Vidyanagri Santacruz (E), Mumbai, 400098, - - 2014
Biological macromolecules evolve and function within intracellular environments that are crowded with other macromolecules. Crowding results in surprisingly large quantitative effects on both the rates and the equilibria of interactions involving macromolecules, but such interactions are commonly studied outside the cell in uncrowded buffers. The addition of high concentrations of ...
Yoon Jisoo J Department of Chemistry, Research Institute for Basic Sciences, Kyung Hee University, Seoul 130-701, Korea. - - 2014
A chemosensor compound () consisting of a central ferrocene with two butylaminomethyl arms showed unexpected facile electrochemical oxidation of the secondary amines in proximity to the ferrocene, which was utilized for electrochemical discrimination of phthalic acid selectively over two other isomers, isophthalic acid and terephthalic acid.
Ozkul Yilmaz Y From the Department of Otorhinolaryngology, Izmir Katip Celebi University, Ataturk Training and Research Hospital, Izmir, - - 2014
The aim of our study was to determine the effectiveness of intratympanic α-lipoic acid injection as an otoprotective agent against cisplatin-induced ototoxicity in guinea pigs. Twenty-four adult male albino guinea pigs with normal hearing were divided into 4 groups. The guinea pigs received intraperitoneal cisplatin in group 1, intraperitoneal cisplatin ...
Sittiwong Wantanee W Department of Chemistry, University of Nebraska-Lincoln, Lincoln, NE 68588-0304 - - 2014
Eleven fatty acid analogues incorporating four-membered carbocycles (cyclobutenes, cyclobutanes, cyclobutanones, and cyclobutanols) were investigated for the ability to inhibit the growth of Mycobacterium smegmatis (Msm) and Mycobacterium tuberculosis (Mtb). A number of the analogues displayed inhibitory activity against both mycobacterial species in minimal media. Several of the molecules displayed potent ...
Torres-Moreno M M Health Sciencies and Welfare Faculty, Department of Health and Social Action, University of Vic - Central University of Catalonia, Vic, Spain. Electronic address: - - 2015
Nutritional composition and fatty acids (FA) profile were determined in cocoa and chocolates of different geographical origin and subject to different processing conditions. Cocoa butter was the major nutrient in cocoa beans and carbohydrates were the most important in chocolates. Cocoa composition and FA profile varied depending on geographical origin ...
Rabinovitz Sharon S School of Criminology, University of Haifa, Israel; Psychopharmacology Laboratory, Bar Ilan University, Israel - - 2014
Cigarette smoke induces oxidative stress with subsequent polyunsaturated fatty acids (PUFAs) peroxidation. Low concentrations of omega-3 PUFAs can affect neurotransmission, resulting in hypofunctioning of the mesocortical systems associated with reward and dependence mechanisms and thus may increase cigarette craving, hampering smoking cessation efforts. PUFA deficiency, in particular eicosapentaenoic acid (EPA; ...
Wang Hong-Lei HL Department of Biology, Lund University, 223 62, Lund, Sweden, - - 2014
Representatives of the highly speciose tropical butterfly genus Bicyclus (Lepidoptera: Nymphalidae) are characterized by morphological differences in the male androconia, a set of scales and hair pencils located on the surface of the wings. These androconia are assumed to be associated with the release of courtship pheromones. In the present ...
Pei Fei F College of Food Science and Technology, Nanjing Agricultural University, Nanjing 210095, PR - - 2014
Button mushroom slices were dehydrated using freeze drying (FD) or FD combined with microwave vacuum drying (FMVD), and the non-volatile component profiles were studied. The results showed that the level of non-volatile components in button mushroom firstly increased during sublimation of FD/FMVD process and then fell during desorption in FD ...
Karlsson Isabella - - 2014
Photocontact allergy is a well-known side effect of topical preparations of the nonsteroidal anti-inflammatory drug ketoprofen. Photocontact allergy to ketoprofen appears to induce a large number of photocross-allergies to both structurally similar and structurally unrelated compounds. Contact and photocontact allergy is explained by structural modification of skin proteins by the ...
Zhang Hong-Jia HJ College of Life Science and Technology, Beijing University of Chemical Technology, Beijing, 100029, - - 2014
Steam explosion is the most promising technology to replace conventional acid hydrolysis of lignocellulose for biomass pretreatment. In this paper, a new screw-steam-explosive extruder was designed and explored for xylose production and lignocellulose biorefinery at the pilot scale. We investigated the effect of different chemicals on xylose yield in the ...
Ma Guobin G School of Materials Science and Engineering, Department of Chemistry, Shanghai University, Shanghai 200444, China. wanwen@staff.shu.edu.cn - - 2014
A copper-mediated gem-difluoromethylenation of aryl, heteroaryl and vinyl boronic acids with bromodifluoromethylated oxazole or thiazole derivatives has been developed. This novel reaction showed an excellent functional group tolerance and wide substrate scope, providing facile access to practical application in drug discovery and development.
Smyrniotis Christopher J - - 2014
5-LOX reacts with AA to first generate 5(S)-hydroperoxy-6E,8Z,11Z,14Z-eicosatetraenoic acid (5(S)-HpETE) and then an epoxide from 5(S)-HpETE to form leukotriene A4, from a single polyunsaturated fatty acid (PUFA). The current work investigates the kinetic mechanism of these two processes and the role of ATP in their activation. Specifically, it was determined ...
Mercali Giovana Domeneghini - - 2014
In this work, the influence of electric field frequency and solids content on the degradation kinetics of ascorbic acid during ohmic heating of acerola pulp and acerola serum was investigated. The degradation percentage of ascorbic acid in the pulp after 120 min of heating varied between 12 and 17%. For ...
Xiao Chaoni C College of Life Sciences, Northwest University, Xi'an, 710069, - - 2014
Weak self-interaction plays an important role in interpreting the biomechanisms and modes of drug action. The structure-dependent self-association of five phenolic acids with various bioactivities, including danshensu (DSS), caffeic acid (CA), rosmarinic acid (RA), lithospermic acid (LA), and salvianolic acid B (SA), was investigated by (1) H NMR. These phenolic ...
Tian Yu-Jing YJ School of Medical Engineering, Hefei University of Technology , Hefei, Anhui 230009, P. R. - - 2014
A platinum(II) acetylide-based bolaamphiphile equipped with two peripheral B18C6 moieties has been successfully prepared, which demonstrates cooperative recognition behavior toward l-alanine ester salt in chloroform. In a polar methanol/chloroform (3/1, v/v) medium, the amino acid additives influence the aggregation of the bolaamphiphile significantly, leading to the morphological transition from nanospherical ...
Yu Jia-Le JL State Key Laboratory of Bioreactor Engineering, School of Biotechnology, East China University of Science and Technology, 130 Meilong Road, Shanghai, 200237, - - 2014
The C6 dicarboxylic acid, adipic acid, is an important platform chemical in industry. Biobased production of adipic acid is a promising alternative to the current petrochemical route. Here we report biosynthesis of adipic acid using an artificial pathway inspired by the reversal of beta-oxidation of dicarboxylic acids. The biosynthetic pathway ...
Liu Hung-Wen - - 2014
Toona Sinensis (T. sinensis) leaf (TSL) has been shown to lower plasma triacylglycerol levels and diminish the size of visceral fat cells in vivo. The molecular mechanism of TSL ethanol extract (TSL-E) on lipid metabolism in 3T3-L1 adipocytes was investigated in this study. Oil Red O staining as well as ...
Teramoto Hidetoshi - - 2014
Silk fibroin incorporated with unnatural amino acids was produced by in vivo feeding of p-chloro-, p-bromo-, and p-azido-substituted analogues of L-phenylalanine (Phe) to transgenic silkworms (Bombyx mori) that expressed a mutant of phenylalanyl-tRNA synthetase with expanded substrate recognition capabilities in silk glands. Cutting down the content of Phe in the ...
Peterson Eric C EC Department of Chemical Engineering, Dupuis Hall, 19 Division St. Queen's University, Kingston Ontario, Canada, - - 2014
Through the use of high partial pressures of CO2 (pCO2 ) to achieve temporary pH reductions in two-phase partitioning bioreactors (TPPBs), improved pH dependent partitioning of butyric acid was observed which achieved in situ product recovery (ISPR), alleviating end-product inhibition (EPI) during the production of butyric acid by Clostridium tyrobutyricum ...
Isca Vera M S VM Department of Chemistry & QOPNA, University of Aveiro, Campus de Santiago, 3810-193 Aveiro, Portugal. Electronic address: - - 2014
Salicornia ramosissima J. Woods is considered, in the Iberian Peninsula and France, a gourmet product. Nevertheless, is one of the less studied Salicornia species. In this work, GC-MS was employed to, for the first time; fully characterise the lipophilic profile of S. ramosissima and to assess the effect of natural ...
Yang Huaiyu - - 2014
Amino acid transporters in plants are crucial for distributing amino acids between plant organs and cellular compartments. The H(+)-coupled plasma membrane transporter CAT1 (cationic amino acid transporter 1) facilitates the high-affinity uptake of basic amino acids. The uptake of lysine (Lys) via the roots was not altered in loss-of-function mutants, ...
Dudek Magdalena M Department of Pharmacodynamids, Jagiellonian University, Medical College, Kraków, Poland. Electronic address: - - 2014
The cardiovascular effects of alpha lipoic acid were evaluated in isolated rat hearts exposed to ischemia-reperfusion injury in vitro. Alpha-lipoic acid raised the level of sulfane sulfur playing an important role in the release of hydrogen sulfide. H2S was shown to prevent the post-reperfusion arrhythmias and to protect the cardiomyocytes ...
Beer Kenneth R KR Kenneth R Beer MD - General, Esthetic and Surgical Dermatology, West Palm Beach, FL, - - 2014
Botulinum toxins are currently used to reduce facial muscle activity, and hyaluronic acid is used to correct volume loss. This study evaluates the combination of abobotulinumtoxinA (Dysport) and hyaluronic acid 20 mg/mL (Perlane) for rejuvenating specific areas of the upper face. Subjects (n = 20) with mild to moderate temporal volume loss as ...
Dugan Christine E CE Department of Nutritional Sciences, University of Connecticut, Storrs, - - 2014
Metabolic syndrome (MetS), characterized by central obesity, dyslipidemias, hypertension, and hyperglycemia, impacts 34 percent of the U.S. adult population. MetS has been demonstrated to be affected by dietary components. Data from epidemiological studies and clinical interventions suggest that one or more dairy components might directly affect MetS parameters. For example, ...
Espahbod Camelia C NYU College of Dentistry, New York, - - 2014
Data sourcesMedline, Embase and the reference lists of identified articles were also scanned for relevant papers.Study selectionOnly randomised controlled trials in English were considered.Data extraction and synthesisTwo reviewers extracted data independently and study quality was assessed using the Jadad score. Meta-analysis was conducted.ResultsFour RCTs with a total of 183 patients ...
Kim Myung Chul MC College of Pharmacy, Chung-Ang University, Seoul 156-756, - - 2014
To investigate the underlying mechanisms of C18 fatty acids (stearic acid, oleic acid, linoleic acid and α-linolenic acid) on mast cells, we measured the effect of C18 fatty acids on intracellular Ca(2+) mobilization and histamine release in RBL-2H3 mast cells. Stearic acid rapidly increased initial peak of intracellular Ca(2+) mobilization, ...
Pszczolkowski Maciej A - - 2014
The idea of enhancing insecticide efficacy against phytophagous insects with feeding stimulators was proposed as early as the 1960s, and a number of insect feeding stimulators based on sugars, molasses, and cottonseed extracts, biologically active at relatively high (5% and higher) concentrations, have been advocated. Here, we show that an ...
Outlaw Victor K VK Department of Chemistry, The Johns Hopkins University, Remsen Hall, 3400 N. Charles Street, Baltimore, MD 21218, - - 2014
Despite a rising demand for anti-obesity therapeutics, few effective pharmacological options are clinically available that target the synthesis and accumulation of body fat. Moderate inhibition of mammalian glycerol-3-phosphate acyltransferase (GPAT) with 2-(alkanesulfonamido)benzoic acids has recently been described in vitro, accompanied by promising weight loss in vivo. In silico docking studies ...
Esquivel-Elizondo S S Bioprocesses Department, Unidad Profesional Interdisciplinaria de Biotecnología, Instituto Politécnico Nacional, P.O. Box 07340, Mexico City, - - 2014
Dark fermentation for bio-hydrogen (bio-H2) production is an easily operated and environmentally friendly technology. However, low bio-H2 production yield has been reported as its main drawback. Two strategies have been followed in the past to improve this fact: genetic modifications and adjusting the reaction conditions. In this paper, the second ...
Ammar Ehab Mohamed EM William G. Lowrie Department of Chemical and Biomolecular Engineering, The Ohio State University, 140 West 19th Avenue, Columbus, OH, 43210, - - 2014
Propionic acid is currently produced mainly via petrochemicals, but there is increasing interest in its fermentative production from renewable biomass. However, the current propionic acid fermentation process suffers from low product yield and productivity. In this work, the gene encoding phosphoenolpyruvate carboxylase (PPC) was cloned from Escherichia coli and expressed ...
Bi Hongkai H Department of Microbiology and 3Biochemistry, B103 Chemical and Life Sciences Laboratory, University of Illinois, 601 S. Goodwin Ave, Urbana, Illinois 61801, - - 2014
In Xanthomonas campestris pv. campestris (Xcc), the proteins encoded by the rpf (regulator of pathogenicity factor) gene cluster produce and sense a fatty acid signal molecule called diffusible signaling factor (DSF, 2(Z)-11-methyldodecenoic acid). RpfB was reported to be involved in DSF processing and was predicted to encode an acyl-CoA ligase. ...
Botha Claude C Centre for Digestive Diseases, Blizard Institute of Cell & Molecular Science, Wingate Institute of Neurogastroenterology, Barts and the London School of Medicine & Dentistry, Queen Mary University of London, London, - - 2014
Autonomic nervous system dysfunction has been implicated in visceral hypersensitivity. However, the specific contribution of the parasympathetic nervous system (PNS) is unclear. We aimed to determine whether physiological and pharmacological manipulation of parasympathetic tone influences the development of hypersensitivity in a validated model of acid-induced oesophageal pain. Prior to, and ...
Schebb Nils Helge NH Institute for Food Toxicology and Analytical Chemistry, University of Veterinary Medicine Hannover, Germany. Electronic address: - - 2014
It is believed that many of the beneficial effects of long-chain omega-3 polyunsaturated fatty acids (LC n-3 PUFA) are mediated by their oxidized metabolites, the oxylipins. The formation and biological role of many cytochrome P450 and lipoxygenase derived hydroxy, epoxy and dihydroxy FA, particularly of oxylipins esterified in polar lipids ...
Lee In-Kyoung IK Division of Biotechnology and Advanced Institute of Environment and Bioscience, Chonbuk National University, 79 Gobong-ro, Iksan-si 570-752, Republic of - - 2014
Ten phenylpropanoic acid esters were isolated from an ethanolic extract of Korean propolis. Their structures were elucidated by spectroscopic methods including NMR and ESI-MS. Caffeic acid esters with catechol moiety exhibited significant ABTS and DPPH radical scavenging activity and protective effect against DNA damage by a Fenton reaction.
Pappas Ioannis A IA Chemical Process Engineering Research Institute, LPRE, 6th km Harilaou Thermi Road, 57001 Thessaloniki, Greece; Aristotle University, Department of Forestry and Natural Environment, Range Ecology Laboratory, 54124 Thessaloniki, Greece. Electronic address: - - 2014
The effect of dilute acid pretreatment severity on the bioconversion efficiency of Phalaris aquatica lignocellulosic biomass into fermentable sugar monomers was studied. The pretreatment conditions were expressed in a combined severity factor (CSF), ranged from 0.13 to 1.16. The concentration of xylose and total monomeric sugars released from hemicellulose increased ...
Botsoglou Evropi E Laboratory of Hygiene of Foods of Animal Origin, Faculty of Veterinary Medicine, University of Thessaly, Karditsa, - - 2014
Our previous study has demonstrated the protective effects of olive leaf extracts on the oxidation of pork patties from n-3 fatty acid-enriched meat during refrigerated storage. The target of the present study was to examine these effects during frozen storage. Results showed that frozen storage accelerated (P=0.05) both lipid and ...
Widenhorn-Müller Katharina K Transfer Center for Neuroscience and Learning, University Hospital, Ulm, Germany; Department of Psychiatry, University Hospital, Ulm, Germany. Electronic address: - - 2014
To determine whether supplementation with the long-chain omega-3 polyunsaturated fatty acids eicosapentaenoic (EPA) and docosahexaenoic acid (DHA) affects behavioral symptoms and cognitive impairments in children 6-12 years of age diagnosed with attention-deficit/hyperactivity disorder (ADHD). The randomized, double-blind placebo-controlled 16 weeks trial was conducted with 95 children diagnosed with ADHD according ...
Hao Guangfei G State Key Laboratory of Food Science and Technology, School of Food Science and Technology, Jiangnan University, Wuxi, 214122, People's Republic of - - 2014
Malic enzyme (ME) catalyses the oxidative decarboxylation of L-malate to pyruvate and provides NADPH for intracellular metabolism, such as fatty acid synthesis. Here, the mitochondrial ME (mME) gene from Mortierella alpina was homologously over-expressed. Compared with controls, fungal arachidonic acid (ARA; 20:4 n-6) content increased by 60 % without affecting the ...
Katz Jonathan R JR School of Life Sciences, University of Sussex, Falmer, Brighton, BN1 9QJ, - - 2014
The interaction of small molecules with non-covalent assemblies is of wide interest. The use of a magnetically active reporter nucleus allows information to be obtained in the presence of spectral overlap or in cases of high dynamic range. In this paper, we explore the interaction of a larger probe molecule, ...
Maeda K K Department of Biological Mechanisms and Functions, Graduate School of Bioagricultural Sciences, Nagoya University, Chikusa, Nagoya, Aichi, 464-8601, - - 2014
Acivicin is an inhibitor of γ-glutamyl transpeptidase and glutamine amidotransferase. When grown on a synthetic minimal agar medium, acivicin strongly inhibited the growth of Magnaporthe oryzae and Alternaria brassicicola, and to a lesser extent, Botrytis cinerea. However, only partial or marginal growth inhibition was observed with regard to Fusarium sporotrichioides ...
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