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Kobayashi Keiichi K Department of Applied Chemistry, Faculty of Science and Engineering, Waseda University, 3-4-1 Ohkubo, Shinjuku-ku, Tokyo, 169-8555, - - 2014
The filamentous fungus Aspergillus niger is used worldwide in the industrial production of citric acid. However, under specific cultivation conditions, citric acid-producing strains of A. niger accumulate oxalic acid as a by-product. Oxalic acid is used as a chelator, detergent, or tanning agent. Here, we sought to develop oxalic acid ...
Wang Zikun Z Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 130022, China. yjliang@ciac.ac.cn - - 2014
A novel copper-catalyzed formal O-H insertion of α-diazo-1,3-dicarbonyl compounds to carboxylic acids has been developed, providing a straightforward synthetic method for α-acyloxy-1,3-dicarbonyl compounds, in which the activation of carboxylic acids by isocyanide plays a crucial role.
Teng Yinglai Y Biobased Commodity Chemistry, Wageningen University, Bornse Weilanden 9, 6708, WG Wageningen, The - - 2014
Amino acids (AAs) derived from hydrolysis of protein rest streams are interesting feedstocks for the chemical industry due to their functionality. However, separation of AAs is required before they can be used for further applications. Electrodialysis may be applied to separate AAs, but its efficiency is limited when separating AAs ...
Yuan Xiaowei X College of Life Sciences, State Key Laboratory of Crop Biology, Shandong Agricultural University, Tai'an 271018, People's Republic of - - 2014
IgASE1, a C18 Δ(9)-specific polyunsaturated fatty acid elongase from the marine microalga Isochrysis galbana, is able to convert linoleic acid and α-linolenic acid to eicosadienoic acid and eicosatrienoic acid in Arabidopsis. Eicosadienoic acid and eicosatrienoic acid are precursors of arachidonic acid, eicosapentaenoic acid, and docosahexaenoic acid, which are synthesized via ...
Rado X0161 Du X0161 Ica DX Instituto de Tecnologia Química e Biológica, Universidade Nova de Lisboa, Av. da República - EAN, 2780-157 Oeiras, - - 2014
Corynebacterium glutamicum wild type produces a mixture of lactic, succinic and acetic acid from glucose under oxygen deprivation. We investigated the effect of CO2 on the production of organic acids in a two-stage process: cells were grown aerobically in glucose and, subsequently, organic acid production by non-growing cells was studied ...
Poverenov Elena - - 2014
Conjugated polymers which can undergo unusual non-oxidative doping were designed. A series of polymers based on donor-acceptor-donor moieties 2,1,3-benzoselenadiazole, 2,1,3-benzothiadiazole, 2,1,3-benzoxadiazolebenzo[2,1,5]oxodiazole and 2-hexylbenzotriazole as acceptor fragments and 3,4-ethylenedioxyselenophene (EDOS) and 3,4-ethylenedioxythiophene (EDOT) as donor fragments was prepared. When the studied polymers were reacted with Lewis acids and bases notable optical ...
Ochsenreither Katrin K Institute of Process Engineering in Life Sciences, Section II: Technical Biology, Karlsruhe Institute of Technology (KIT), Engler-Bunte-Ring 1, 76131, Karlsruhe, Germany, - - 2014
L-Malic acid and fumaric acid are C4 dicarboxylic organic acids and considered as promising chemical building blocks. They can be applied as food preservatives and acidulants in rust removal and as polymerization starter units. Molds of the genus Aspergillus are able to produce malic acid in large quantities from glucose ...
Wang Ziqiang Z National Key Laboratory of Biochemical Engineering, Institute of Process Engineering, Chinese Academy of Sciences, Beijing, 100190, - - 2014
An Escherichia coli-engineered bacterium with cis-epoxysuccinate hydrolase (ESH) activity was used to catalyze the stereospecific hydrolysis of cis-epoxysuccinic acid to L-(+)-tartaric acid. The effect of the substrate composition on the production efficiency of L-(+)-tartaric acid was investigated. Based on the sodium-type homogeneous substrate system, a heterogeneous substrate system, composed of ...
O'Mahony Aoife M AM Pharmacodelivery Group, School of Pharmacy, University College Cork, Cork, - - 2014
Modified cyclodextrins (CDs) have shown great promise as non-viral gene and siRNA delivery vectors in a range of in vitro and in vivo studies. In the current study, structural and biophysical characterisation of selected CDs was carried out to enhance our understanding of their interaction with nucleic acids. The methods ...
Hochuli Michel M Division of Endocrinology, Diabetes, and Clinical Nutrition (M.Ho., I.A., P.A.G., G.A.S., K.B.), University Hospital Zurich, 8091 Zurich, Switzerland; Division of Clinical Chemistry and Biochemistry (A.W., M.He., H.T.), University Children's Hospital Zurich, 8032 Zurich, Switzerland; Human Nutrition Laboratory (I.A.), Institute of Food, Nutrition, and Health and Competence Center for Systems Physiology and Metabolic Diseases (P.A.G., G.A.S.), ETH Zurich, 8092 Zurich, Switzerland; Zurich Center for Integrative Human Physiology (K.B.), 8057 Zurich, - - 2014
Context: The impact of sugar-sweetened beverages (SSB) on lipid metabolism when consumed in moderate amounts by normal weight subjects is debated. Objective: The objective of the study was to investigate the effect of different types of sugars in SSB on fatty acid metabolism (ie, fatty acid synthesis and oxidation) in ...
Baba Takashi T Tokyo University of Pharmacy and Life Sciences, - - 2014
Recent studies have suggested that phosphatidic acid (PA), a cone-shaped phospholipid that can generate negative curvature of lipid membranes, participates in mitochondrial fusion. However, precise mechanisms underling the production and consumption of PA on the mitochondrial surface are not fully understood. Phosphatidic acid-preferring phospholipase A1 (PA-PLA1) is the first identified ...
Zhang Yue Y School of Chemical and Pharmaceutical Engineering, Hebei University of Science and - - 2014
A set of polyethylene glycol (PEG)-resveratrol (RES) conjugates with amino acid as spacers was designed and synthesized to improve certain defects of resveratrol, such as poor stability and solubility, its short half-life and the difficulty of obtaining controlled release. Amino acids, which are released along with resveratrolRES, are necessary for ...
Ng Fo-Ning FN State Key Laboratory of Chirosciences, Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hung Hom, Kowloon (Hong Kong), Fax: - - 2014
A Rh(III) -catalyzed direct ortho-CH amidation/amination of benzoic acids with N-chlorocarbamates/N-chloromorpholines was achieved, giving anthranilic acids in up to 85 % yields with excellent ortho-selectivity and functional-group tolerance. Successful benzoic acid aminations were achieved with carbamates bearing various amide groups including NHCO2 Me, NHCbz, and NHTroc (Cbz=carbobenzyloxy; Troc=trichloroethylchloroformate), as well as ...
Li Shiqing S Key Laboratory of Green Chemistry and Technology of Ministry of Education, College of Chemistry, Sichuan University, 29 Wangjiang Road, Chengdu 610064, PR China. gg2b@scu.edu.cn - - 2014
Imidazolium salts were conveniently prepared by direct aryl quaternization using arylboronic acids. This process features the tolerance of a broad range of functional groups and excellent chemoselectivity, and is especially effective for the synthesis of unsymmetrical imidazolium salts.
You H H a Department of Biotechnology , Yonsei University , Seoul , - - 2014
Gas phase acidity and basicity estimation models have been developed for acidic and basic functional groups of amino acid side-chains and also for a number of small organic molecules. The acidic functional groups include aliphatic and aromatic alcohol, and aliphatic and aromatic carboxylic acid, and the basic functional groups include ...
McEntee Monica - - 2014
The oxidative-dehydrogenation of carboxylic acids to selectively produce unsaturated acids at the second and third carbons regardless of alkyl chain length was found to occur on a Au/TiO2 catalyst. Using transmission infrared spectroscopy (IR) and density functional theory (DFT), unsaturated acrylate (H2C=CHCOO) and crotonate (CH3CH=CHCOO) were observed to form from ...
Wang Jiani J State Key Laboratory of Marine Geology, Tongji University, Shanghai, People's Republic of - - 2014
Pressure is an important thermodynamic property of the ocean and the deep biosphere that affects microbial physiology and biochemistry. Here, we report on our investigation of the response of Gram-positive piezotolerant bacterium Sporosarcina sp. DSK25 to hydrostatic pressure. Strain DSK25 responded in an adaptive manner to upshifts of growth pressure ...
Kis Olena O Department of Pharmaceutical Sciences, Leslie Dan Faculty of Pharmacy, University of Toronto, 144 College Street, Room 1001, Toronto, Ontario, M5S 3M2, - - 2014
The objectives of this study were to evaluate the effects of intestinal lumen pH, food intake, and acid-reducing agents on the intestinal permeability of atazanavir, an HIV-1 protease inhibitor. Atazanavir permeability across Caco-2 cell monolayers (P app) and in situ steady-state permeability across rat jejunum and ileum (P eff) were ...
Feng Lin-Min LM State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing, - - 2014
Cycloastragenol (CA) is the genuine sapogenin of astragaloside IV (ASI). This study focuses on the preparation of CA from ASI. Five hydrolysis methods were compared including H2SO4 hydrolysis, HCl hydrolysis, two-phase acid hydrolysis, mild acid hydrolysis, and Smith degradation. Seven hydrolysis products were purified, and five of them were identified ...
Kapetanakou A E AE Agricultural University of Athens, Department of Food Science and Human Nutrition, Laboratory of Food Quality Control & Hygiene, Iera Odos 75, GR-11855 Athens, - - 2014
The present study aimed to evaluate the effect of AB vapors on microbial, physicochemical, and sensory profile of pork meat stored in different MAP conditions. Pork pieces (10g) and cotton/cellulose absorbent cloths (2×2cm) were placed into compartmentalized Petri-dishes in two sections. Aliquots (1mL) of water (control), 30% v/v and 40% ...
Reyes-Darias José A JA Instituto de Parasitología y Biomedicina "López-Neyra", CSIC (IPBLN-CSIC), PTS Granada, Avda. del Conocimiento s/n, Armilla, 18016 Granada, - - 2014
Transfection of mammalian cells or in vivo administration of nucleic acids can induce inflammatory cytokines and/or interferon response, which could significantly influence the ex vivo or in vivo applications of gene-targeting strategies based on nucleic acids. Further induction of the interferon and inflammatory related stress responses may result in off-target effects and toxicity. ...
Cao Cao - - 2014
Autocatalytic hydrolysis of fatty acid anhydrides induced by the spontaneously formed vesicles has been studied for years. However, whether the reaction autocatalyzed by vesicles formed in diluted solutions applies also to macromolecular crowded conditions remains unknown. The aim of this study is to characterize hydrolysis behavior of fatty acid anhydrides ...
Kara Yusuf Y Serik Central Hospital, Medical Biochemistry Department, Antalya, Turkey. Electronic address: - - 2014
Chronic inflammation occurs systematically in the central nervous system during ageing, it has been shown that neuroinflammation plays an important role in the pathogenesis of many neurodegenerative disorders. Aspirin, a nonselective COX inhibitor, as well as ascorbic acid, has been purported to protect cerebral tissue. We investigated the effects of ...
Sajewicz Mieczyslaw M Institute of Chemistry, University of Silesia, 9 Szkolna Street, 40-006 Katowice, - - 2014
We employ the achiral liquid chromatography with diode array, evaporative light scattering and mass spectrometric detection (HPLC-DAD, HPLC-ELSD and LC-MS) to assess structural instability (understood as spontaneous oscillatory chiral conversion and spontaneous oscillatory condensation) of the two pairs of amino acids, l-proline-l-phenylalanine (l-Pro-l-Phe) and l-hydroxyproline-l-phenylalanine (l-Hyp-l-Phe), in aqueous acetonitrile. In ...
Li Xihong X Key Laboratory of Food Nutrition and Safety, Tianjin University of Science and Technology, Ministry of Education, Tianjin, - - 2014
Ascorbic acid dip and high O2 modified atmosphere packaging were used to alleviate browning and quality loss of fresh-cut eggplants. Fresh-cut eggplants were dipped in water or 0.5% ascorbic acid solution for 2 min before being packed in polyethylene film bags filled with air or high O2. The physiochemical and sensorial ...
Alqarawi A A AA King Saud University Plant Production Department, College of Food & Agriculture Sciences P. O. Box 2460 Riyadh 11451 Saudi - - 2014
The present work was carried out to uncover the effect of salinity stress on shoot moisture percentage, pigment content and lipid composition of Ephedra alata Decne. The results suggested that salinity caused significant decrease in plant moisture content. The chl. a, b and carotenoids showed significant decrease with increasing concentration ...
Dumont Jennifer J INRA, UMR1137 EEF, F-54280 Champenoux, - - 2014
Ozone is an air pollutant that causes oxidative stress by generation of reactive oxygen species (ROS) within the leaf. The capacity to detoxify ROS and repair ROS-induced damage may contribute to ozone tolerance. Ascorbate and glutathione are known to be key players in detoxification. Ozone effects on their biosynthesis and ...
Laohakunjit Natta N Division of Biochemical Technology, School of Bioresources and Technology, King Mongkut's University of Technology Thonburi, 49 Tientalay 25 Rd., Takham, Bangkhuntien, Bangkok 10150, Thailand. Electronic address: - - 2014
An enzymatic bromelain seaweed protein hydrolysate (eb-SWPH) was characterised as the precursor for thermally processed seafood flavour. Seaweed (Gracilaria fisheri) protein after agar extraction was hydrolysed using bromelain (enzyme activity=119,325U/g) at 0-20% (w/w) for 0.5-24h. Optimal hydrolysis conditions were determined using response surface methodology. The proposed model took into account ...
Johnson Kelly S KS Department of Biological Sciences, Ohio University, Athens, OH, 45701, USA, - - 2014
The spatial congruence of chemical and biological recovery along an 18-km acid mine impaired stream was examined to evaluate the efficacy of treatment with an alkaline doser. Two methods were used to evaluate biological recovery: the biological structure of the benthic macroinvertebrate community and several ecosystem processing measures (leaf litter ...
Bock Harald H Centre de Recherche Paul Pascal, CNRS & Université de Bordeaux , 115 avenue Schweitzer, 33600 Pessac, - - 2014
Perkin condensations of arylglyoxylic acids with arylacetic acids, followed by the addition of alkylamine, yield diarylmaleimides in a one-pot procedure. The arylglyoxylic acids are obtained by arene acylation with ClCOCO2Et and reduced with NaI and hypophosphorous acid to the arylacetic acids. With 2,7-di-tert-butyl-pyren-4-yl or chrysen-6-yl as the aryl, photocyclodehydrogenation of ...
Li Yan Y State Key Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou, Gansu 730000, - - 2014
To optimize antioxidant activity and lipophilicity of cinnamic acid derivatives (CAs) including ferulic acid, sinapic acid, 3,4-dimethoxycinnamic acid, and p-hydroxycinnamic acid, four analogs bearing an additional double bond between their aromatic ring and propenoic acid moiety were designed and synthesized based on the conjugated chain elongation strategy. The antioxidant performance ...
Niwa Masahiro M Pharmaceutical Technology R&D Laboratories; CMC Center, Takeda Pharmaceutical Company Ltd., 2-17-85 Jusohonmachi, Yodogawa-ku, Osaka, 532-8686, Japan, - - 2014
Enteric coatings are used to reduce gastrointestinal side effects and control the release properties of oral medications. Although widely used, the effect of formulation and process conditions on physicochemical and functional properties of enteric coatings remains unclear. Terahertz pulsed imaging (TPI) was employed to evaluate the coat properties of enteric ...
Byzia Anna A Division of Bioorganic Chemistry, Faculty of Chemistry, Wroclaw University of Technology, Wybrzeze Wyspianskiego 27, 50-370, Wrocław, - - 2014
Leukotriene A4 hydrolase (LTA4H--EC 3.3.2.6) is a bifunctional zinc metalloenzyme, which processes LTA4 through an epoxide hydrolase activity and is also able to trim one amino acid at a time from N-terminal peptidic substrates via its aminopeptidase activity. In this report, we have utilized a library of 130 individual proteinogenic ...
Adamek Jakub - - 2014
A variety of N-(1-methoxyalkyl)amides or carbamates react readily with sodium aryl sulfinates in the presence of triphenylphosphonium tetrafluoroborate or bromide in CHCl3 under mild conditions to give 1-(N-acylamino)alkyl sulfones in good yields. A combinaton of this reaction with the recently described electrochemical decarboxylative alpha-methoxylation of N-acyl-alpha-amino acids to N-(1-methoxyalkyl)amides in ...
Yang Meiyan M State Key Laboratory of Food Science and Technology, Nanchang University , Nanchang , China - - 2014
Abstract To assess effects of heated edible oils on intake of trans fatty acids (TFAs); the formation of TFAs in cooking conditions was investigated by a frying system model, in which chicken fillet was fried in a commercial corn oil at 170 °C, for 12 frying cycles. The main TFAs detected ...
Zhang Yu-Fei - - 2014
Omega-3 fatty acids are known to prevent cardiac death. However, previous observational studies have suggested that omega-3 fatty acids are associated with cancer risk in adults. We conducted a meta-analysis based on randomized controlled trials to evaluate the effect of omega-3 fatty acids on the risk of cancer incidence, nonvascular ...
Sung Jin-Hee JH Department of Anatomy, College of Veterinary Medicine, Research Institute of Life Science, Gyeongsang National University, 900 Gajwa-dong, Jinju 660-701, South - - 2014
Ferulic acid, a phenolic phytochemical compound found in various plants, has a neuroprotective effect through its anti-oxidant and anti-inflammation functions. Peroxiredoxin-2 and thioredoxin play a potent neuroprotective function against oxidative stress. We investigated whether ferulic acid regulates peroxiredoxin-2 and thioredoxin levels in cerebral ischemia. Sprague-Dawley rats (male, 210-230g) were treated ...
Miyagi Junko J Department of Psychiatry, Tokyo Women's Medical University, 8-1, Kawada-Cho, Shinjuku-Ku, Tokyo 168-8666, - - 2014
Valproic acid, an established antiepileptic and antimanic drug, has recently emerged as a promising emotion-stabilizing agent for patients with psychosis. Although dopamine transmission in the amygdala plays a key role in emotional processing, there has been no direct evidence about how valproic acid acts on the dopaminergic system in the ...
Gómez Alexia A Department of Animal Physiology-II, Faculty of Biological Sciences, Complutense University of Madrid (UCM), Madrid, - - 2014
The membrane fatty acid unsaturation hypothesis of aging and longevity is experimentally tested for the first time in mammals. Lifelong treatment of mice with the β1-blocker atenolol increased the amount of the extracellular-signal-regulated kinase signaling protein and successfully decreased one of the two traits appropriately correlating with animal longevity, the ...
Chang Cheng C Biotechnology Center, National Chung-Hsing University, Taichung, 40227, Taiwan, - - 2014
Over 1,000-fold carbofuran resistance has been observed in Chilo suppressalis (Walker) collected from Changhua (CH) and Chiayi (CY) prefectures of Taiwan.(1) An understanding of the pertinent mechanisms will benefit effective insecticide resistance management of C. suppressalis. Among the five amino acid substitutions of acetylcholinesterase (AChE) identified in C. suppressalis, A314S ...
Weyda István I Section for Sustainable Biotechnology, Aalborg University Copenhagen, A. C. Meyers Vænge 15, 2450, Copenhagen SV, - - 2014
Aspergillus carbonarius accumulates xylitol when it grows on D-xylose. In fungi, D-xylose is reduced to xylitol by the NAD(P)H-dependent xylose reductase (XR). Xylitol is then further oxidized by the NAD(+)-dependent xylitol dehydrogenase (XDH). The cofactor impairment between the XR and XDH can lead to the accumulation of xylitol under oxygen-limiting ...
Yang Xue X Xinjiang Institute of Ecology and Geography, Chinese Academy of Sciences, Urumqi, Xinjiang 830011, China; School of Municipal and Environmental Engineering, Harbin Institute of Technology, Harbin 150090, - - 2014
This study adopted rapid alkaline treatment at pH 12 to hydrolyze 66% of total chemical oxygen demands. Then the hydrolyzed liquor was fermented in a continuous-flow stirred reactor to produce volatile fatty acids (VFAs) at 8-h hydraulic retention time and at 35°C. The maximum VFA productivity reached 365mg VFAsg(-1) volatile ...
Perez Adrián A AA Consejo Nacional de Investigaciones Científicas y Técnicas de la República Argentina, Argentina; Grupo de Biocoloides, Instituto de Tecnología de Alimentos, Universidad Nacional del Litoral, 1 de mayo 3250, 3000 Santa Fe, - - 2014
The aim of this work was to obtain heat-induced β-lactoglobulin (BLG) aggregates in order to test them as carriers of a model polyunsaturated fatty acid (PUFA), linoleic acid (LA). BLG aggregates were obtained at 85°C by varying the heating time (0-60min) and pH of protein dispersion (6.5-7.5). Aggregates were characterised ...
Ralston J C JC Department of Human Health and Nutritional Sciences, University of Guelph, Guelph, Ontario, - - 2014
Background:Stearoyl-CoA desaturase-1 (SCD1) is rate-limiting for the conversion of saturated fatty acids palmitate (16:0) and stearate (18:0) to monounsaturated fatty acids palmitoleate (16:1n7) and oleate (18:1n9), respectively. Given that reduced SCD1 activity is associated with improved insulin sensitivity and decreased body weight, there is considerable interest to elucidate the role ...
Lin Yuheng Y College of Engineering, University of Georgia, Athens, GA 30602, - - 2014
cis,cis-Muconic acid (MA) and salicylic acid (SA) are naturally-occurring organic acids having great commercial value. MA is a potential platform chemical for the manufacture of several widely-used consumer plastics; while SA is mainly used for producing pharmaceuticals (for example, aspirin and lamivudine) and skincare and haircare products. At present, MA ...
Logan Sreemathi S University of Oklahoma HSC, United - - 2014
Autosomal dominant Stargardt-like macular dystrophy (STGD3) in humans results from mutations in Elongation of Very Long chain fatty acids like-4 (ELOVL4), which leads to vision loss in young adults. ELOVL4 is an integral endoplasmic reticulum (ER) protein that mediates the elongation of very long chain (VLC) fatty acids. Mutations in ...
Chan S S M SS Department of Medicine, Norwich Medical School University of East Anglia, Norwich, UK; Norfolk & Norwich University Hospitals NHS Trust, Norwich, - - 2014
There are plausible mechanisms for how dietary docosahexaenoic acid (DHA), an n-3 polyunsaturated fatty acid, could prevent Crohn's disease (CD). To conduct a prospective study to investigate the association between increased intake of DHA and risk of CD. Overall, 229 702 participants were recruited from nine European centres between 1991 and ...
Santos Samantha Christine SC Department of Hydraulic and Sanitation, University of São Paulo, Av. Trabalhador Sãocarlense, 400, Centro, CEP 13566-590, São Carlos, SP, - - 2014
This study aimed to evaluate the effect of high organic loading rates (OLR) (60.0-480.00kgCODm(-3)d(-1)) on biohydrogen production at 55°C, from sugarcane stillage for 15,000 and 20,000mgCODL(-1), in two anaerobic fluidized bed reactors (AFBR1 and AFBR2). It was obtained, for H2 yield and content, a decreasing trend by increasing the OLR. ...
Kamata Shotaro S Department of Biochemistry, Keio University Graduate School of Pharmaceutical Sciences, Tokyo, - - 2014
Dietary deprivation of essential amino acids (EAAs) in mammals is known to cause reductions in food intake and body weight. The aim of this study was to determine whether and how mice respond to deprivation of individual EAA species. Dietary deprivation of any single EAA (not non-EAA) in mice led ...
Li Huiling H State Key Laboratory of Pulp and Paper Engineering, South China University of Technology, Guangzhou 510640, - - 2014
Selectively catalytic hydrothermal pretreatment of corncob into xylose and furfural has been developed in this work using solid acid catalyst (SO4(2-)/TiO2-ZrO2/La(3+)). The effects of corncob-to-water ratio, reaction temperature and residence time on the performance of catalytic hydrothermal pretreatment were investigated. Results showed that the solid residues contained mainly lignin and ...
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