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Hajdu Zsanett Z Department of Pharmacognosy, University of Szeged , H-6720 Szeged, - - 2014
The discovery of the interaction of plant-derived N-alkylamides (NAAs) and the mammalian endocannabinoid system (ECS) and the existence of a plant endogenous N-acylethanolamine signaling system have led to the re-evaluation of this group of compounds. Herein, the isolation of seven NAAs and the assessment of their effects on major protein ...
Abood Walaa Najm - - 2014
Immunomodulators are substances that modify immune system response to a threat. Immunomodulators modulate and potentiate the immune system, keeping it highly prepared for any threat. The immunomodulatory effect of the traditional medicine Tinospora crispa is investigated in this work. T. crispa ethanol extract was fractionated by using different solvents. The ...
Graham Daniel J DJ Department of Chemistry and Chemical Biology, Harvard University, 12 Oxford St, Cambridge, MA 02138 - - 2014
We report a multi-gram scale synthesis of methyl 6-formyl-4-dibenzofurancarboxylate and its subsequent use in the gram scale synthesis of a dibenzofuran-functionalized hangman porphyrin containing a pendant carboxylic acid (HPD-CO2 H). HPD-CO2 H can be isolated as a free carboxylic acid in high purity with minimal purification. Post-synthetic modification of HPD-CO2 ...
Bhat Wajid Waheed WW Plant Biotechnology Division, CSIR - Indian Institute of Integrative Medicine, Canal Road, Jammu Tawi-180001, - - 2014
Picrorhiza kurrooa Royle ex Benth. is a highly reputed medicinal herb utilised in the preparation of a number of herbal drug formulations, principally due to the presence of novel monoterpene iridoid glycosides kenned as picrosides. Phenylalanine ammonia-lyase catalyses an important rate-limiting step in phenylpropanoid pathway and supplies precursors like cinnamic ...
Li Yun-Cheng YC College of Light Industry Textile and Food Engineering, Sichuan University, Chengdu, 610064, Sichuan, - - 2014
In the industrial production of bioethanol from lignocellulosic biomass, a strain of Saccharomyces cerevisiae that can ferment xylose in the presence of inhibitors is of utmost importance. The recombinant, industrial-flocculating S. cerevisiae strain NAPX37, which can ferment xylose, was used as the parent to delete the gene encoding p-nitrophenylphosphatase (PHO13) ...
Bo Yang Y Instrumental Analysis Center, Shanghai Jiao Tong University, 800 Dongchuan Road, 200240, Shanghai, - - 2014
Abstract Titanium dioxide nanoparticles (nano TiO2) have been widely applied in daily life and subsequent problem on the potential health risk are raised. Studies on the toxicity of nano TiO2 have shown that nano TiO2 could lead to toxic effects on human and environment. However, the mechanisms are still unclear. ...
Carroll Bernadette B Institute for Ageing and Health, Newcastle University, Campus for Ageing and Vitality, Newcastle upon Tyne, NE4 5PL, - - 2014
Maintenance of amino acid homeostasis is important for healthy cellular function, metabolism and growth. Intracellular amino acid concentrations are dynamic; the high demand for protein synthesis must be met with constant dietary intake, followed by cellular influx, utilization and recycling of nutrients. Autophagy is a catabolic process via which superfluous ...
Estupiñán Mónica M Department of Microbiology, Faculty of Biology, University of Barcelona, Barcelona, Spain; Unitat de Microbiologia i Parasitologia Sanitàries, Facultat de Farmàcia, University of Barcelona, Barcelona, - - 2014
P. aeruginosa displays the ability to perform bioconversion of oleic acid into a class of hydroxylated fatty acids known as oxylipins. A diol synthase activity is responsible for such a conversion, which proceeds through the dioxygenation of oleic acid to release hydroperoxide 10-H(P)OME ((10S)-hydroxy-(8E)-octadecenoic acid), followed by conversion of the ...
Talbot Nicola A NA Department of Comparative Biomedical Sciences, Royal Veterinary College, University of London, Royal College Street, London NW1 0TU, - - 2014
Obesity and saturated fatty acid (SFA) treatment are both associated with skeletal muscle insulin resistance (IR) and increased macrophage infiltration. However, the relative effects of SFA and unsaturated fatty acid (UFA)-activated macrophages on muscle are unknown. Here, macrophages were treated with palmitic acid, palmitoleic acid or both and the effects ...
Zhu Weiqin W Key Laboratory of Hangzhou City for Ecosystem Protection and Restoration, Hangzhou Normal University, Hangzhou, 310036, People's Republic of China, - - 2014
Vermicomposting is an eco-friendly method for disposing of livestock and poultry manure. In addition, dissolved organic matter (DOM) can serve as a carrier that enhances the migration and transformation of heavy metals. Here, pig manure amended with rice straw was vermicomposted with Eisenia fetida. The DOM content, molecular weight distribution, ...
Chang Huazhen H State Key Joint Laboratory of Environment Simulation and Pollution Control (SKLESPC), School of Environment, Tsinghua University, Beijing, 100084, China. - - 2014
A novel mechanism is proposed for the poisoning effect of acid gases and N2O formation on SCR catalysts involving base-acid properties correlated with redox ability of M-O or M-OH (M = Ce or V) of metal oxides and the strength of their basicity responsible for resistance to HCl and SO2 ...
Ortiz Maria Eugenia ME Centro de Referencia para Lactobacilos (CERELA)-CONICET,Chacabuco - - 2014
Summary There are no studies that document the production of prostaglandins (PGs) or their role in Rhinella arenarum oocyte maturation. In this study, we analysed the effect of arachidonic acid (AA) and prostaglandins (PGs) on maturation, activation and pronuclear formation in R. arenarum oocytes. Our results demonstrated that AA was ...
Gao Yu Y The Second Department of Cardiology, The Fifth Affiliated Hospital of Zhengzhou University , Zhengzhou , China - - 2014
Abstract Context: Geniposidic acid, one of the main active ingredients in Gardenia jasminoides J. Ellis (Rubiaceae), may also possess important pharmacological activities for cardiovascular disorders similar to other derivatives, such as geniposide. Objective: To evaluate its anti-atherosclerosis (anti-AS) effect, the related pharmacological activities and possible cellular mechanisms were studied. Materials ...
Krieg Andreas - - 2014
The release behavior of a model compound (β-naphtholorange) encapsulated in (meth)acrylate based statistical copolymers under different environmental conditions was investigated in a structure-property relationship study. Using monomers of varying polarity (methyl acrylate, ethyl acrylate, tert-butyl acrylate, 2-ethylhexyl methacrylate, and benzyl methacrylate) in combination with methacrylic acid, five polymer series were ...
Pędziwiatr-Werbicka Elżbieta E Department of General Biophysics, Faculty of Biology and Environmental Protection, University of Lodz, Pomorska 141/143, 90-236 Lodz - - 2014
Novel silicates were prepared by using silylated natural fatty acids (derived from triglyceride renewable oils) as co-condensing reagents in presence of tetraethyl orthosilicate (TEOS) and the triblock copolymer, pluronic P123, as a structure directing agent. A series of carboxylic acid functionalized SBA-15-type mesoporous silicates were obtained with tunable nanoscopic order ...
Zheng Jing J Institute of Materia Medica and College of Pharmaceutical Sciences, Zhejiang University , 866 Yuhangtang Road, Hangzhou 310058, P. R. - - 2014
A Rh(III)-catalyzed selective coupling of N-methoxy-1H-indole-1-carboxamide and aryl boronic acids is reported. The coupling is mild and efficient toward diverse product formation, with selective C-C and C-C/C-N bond formation. Kinetic isotope effects studies were conducted to reveal a mechanism of C-H activation and electrophilic addition.
Hester Austin G AG Wake Forest University School of Medicine, United - - 2014
Dramatic shifts in the Western diet have led to a marked increase in the dietary intake of the n-6 polyunsaturated fatty acid (PUFA), linoleic acid (LA). Dietary LA can then be converted to arachidonic acid (ARA) utilizing three enzymatic steps. Two of these steps are encoded for by the fatty ...
Salah El Dine Riham R a Department of Pharmacognosy , Faculty of Pharmacy, Cairo University , 11562 Cairo , - - 2014
The α-glucosidase and maltase inhibitory effects of Punica granatum L. flowers (PGF) were investigated. The methanol extract (PGFMe), n-hexane extract (PGFH), chloroform extract (PGFC) and the remaining water fraction (PGFW) were assayed for their α-glucosidase and maltase inhibitory effects. PGFW showed potent α-glucosidase inhibition with IC50 of 0.8 μg/mL followed by ...
Liu Qing Q The MOE Key Laboratory of Standardization of Chinese Medicines, and SATCM Key Laboratory of New Resources and Quality Evaluation of Chinese Medicines, Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine , Shanghai 201210, People's Republic of - - 2014
Six new diterpenoids, 4-epi-7α-O-acetylscoparic acid A (1), 7α-hydroxyscopadiol (2), 7α-O-acetyl-8,17β-epoxyscoparic acid A (3), neo-dulcinol (4), dulcinodal-13-one (5), and 4-epi-7α-hydroxydulcinodal-13-one (6), and a new flavonoid, dillenetin 3-O-(6″-O-p-coumaroyl)-β-d-glucopyranoside (10), along with 12 known compounds, were isolated from the aerial parts of Scoparia dulcis. The 7S absolute configuration of the new diterpenoids 1-4 ...
Forsgård R A RA Institute of Biomedicine, Pharmacology, Medical Nutrition Physiology, University of Helsinki, Helsinki, - - 2014
We have previously shown in mice that the fecal proportion and concentration of the hydrophobic bile acid deoxycholic acid (DCA) is elevated with high-fat feeding and that these changes are able to disrupt the intestinal barrier function. The aim of this study was to investigate whether these changes are mediated ...
Ito Toshihiko T Department of Biological Resource Sciences, Akita Prefectural University, Nakano Shimoshinjyo, Akita 010-0195, - - 2014
Phenolic acid (ferulic and p-coumaric acid) liberation from rice grains was examined using rice samples containing phenolic acid at different levels, using two sake mash simulated digestion tests to elucidate influencing factors. Phenolic acid levels in a digest made from steamed rice using dialyzed rice koji enzymes were smaller than ...
Yan Jing-Kun JK The Key Laboratory of Carbohydrate Chemistry & Biotechnology, Ministry of Education, Jiangnan University, Wuxi 214122, Jiangsu, China; School of Food & Biological Engineering, Jiangsu University, Zhenjiang 212013, China; Department of Applied Biology & Chemical Technology, State Key Laboratory of Chinese Medicine and Molecular Pharmacology in Shenzhen, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong. Electronic address: - - 2014
Polysaccharide-functionalized silver nanoparticles (Oc-AgNPs) with a mean diameter of 15nm were utilized as a novel and effective fluorescence-sensing platform for nucleic acid detection. Tests on the oligonucleotide sequences associated with the human immunodeficiency virus as a model system showed that the Oc-AgNPs effectively absorbed and quenched dye-labeled single-stranded DNA through ...
Koca Nülüfer N Department of Medicinal and Aromatic Plants, Turkoglu Vocational High School, Kahramanmaras Sutcu Imam University, 46100 Turkoglu-Kahramanmaras, Turkey. Electronic address: - - 2015
The effects of methyl jasmonate (MeJA), spermine (Spm), epibrassinolide (EBL) and l-phenylalanine on sweet basil (Ocimum basilicum L.) were studied to determine the amount of phenolic compounds and enzymatic activity of phenylalanine ammonia-lyase (PAL). Total phenolic and total flavonoid contents of sweet basils were determined by a spectrophotometer, and individual ...
Salamanca-Cardona Lucia L Department of Chemistry; State University of New York; College of Environmental Science and Forestry; Syracuse, NY - - 2014
Engineering of microorganisms to directly utilize plant biomass as a feedstock for the biosynthesis of value-added products such as bioplastics is the aim of consolidated bioprocessing. In previous research we successfully engineered E. coli LS5218 to produce polyhydroxyalkanoates (PHAs) from xylan. In this study we report further genetic modifications to ...
Liang Meng-Yao MY Key Laboratory of Agricultural Biological Functional Genes, Northeast Agricultural University, Mucai Street 59, Xiangfang District, Harbin, 150030, Heilongjiang Province, - - 2014
Milk fat is the major energy component of milk, and regulation of its production relies on transcription factors sterol regulatory element-binding protein 1 (SREBP1) and peroxisome proliferator-activated receptor gamma (PPARγ). As one of the target genes of SREBP1 and PPARγ, fatty acid-binding protein 3(FABP3) is the main protein allowing for ...
Rahmati Mitra M INRA, PSH, site agroparc, Avignon, - - 2014
Literature mostly abounds with the impacts of drought conditions on the concentration of non-structural compounds (NSC) and acids in peach fruits without distinction as to the direct effect of drought on fruit metabolism and its indirect effect through dilution. Moreover, there is a need to investigate the sensitivity of the ...
Wu Ya Y Key Laboratory of Applied Surface and Colloid Chemistry, MOE, School of Chemistry and Chemical Engineering, Shaanxi Normal University, Xi'an 710062 (P.R. China), Fax: - - 2014
A binary acid system has been developed that features an air-stable organometallic precursor, titanocene dichloride, and simple organic cooperative Brønsted acids, which allowed for mild and highly efficient Mannich reactions of both aryl and alkyl ketones with excellent yields and satisfactory diastereoselectivity. Mechanistic studies, including (1) H NMR titration, X-ray structure ...
Grosskinsky Dominik K DK University of Copenhagen, Dpt. of Plant and Environmental Sciences, Copenhagen Plant Science Centre, Taastrup, Denmark ; - - 2014
Phytohormones are known as essential regulators of plant defenses, with ethylene, jasmonic and salicylic acid as central immunity backbone, while other phytohormones have been demonstrated to interact with this. Only recently, a function of the classic phytohormone cytokinin in plant immunity has been described in Arabidopsis, rice and tobacco. Although ...
Vereshchagina Y V YV Institute of Biology and Soil Science, Far Eastern Branch of the Russian Academy of Sciences, 159 Stoletija Str., Vladivostok, 690022, - - 2014
Caffeoylquinic acids are found in artichokes, and they are currently considered important therapeutic or preventive agents for treating Alzheimer's disease and diabetes. We transformed artichoke [the cultivated cardoon or Cynara cardunculus var. altilis DC (Asteraceae)] with the rolC gene, which is a known inducer of secondary metabolism. High-performance liquid chromatography ...
Cengiz Fatma Pelin FP Kars State Hospital , Kars , Turkey - - 2014
Abstract Objective: Although there are several methods to treat Verruca plana, warts do not respond well to the common therapeutic options. In this study, we compared the safety and efficacy of 10% trichloroacetic acid, 25% trichloroacetic acid, and cryotherapy for the treatment of warts caused by Verruca plana. Methods: Ten ...
Crapeau Myriam M Universite Libre de Bruxelles (ULB), - - 2014
Gap1, the yeast general amino acid permease, is a convenient model for studying how the intracellular traffic of membrane transporters is regulated. Present at the plasma membrane under poor nitrogen supply conditions, it undergoes ubiquitylation, endocytosis, and degradation upon activation of the TORC1 kinase complex in response to an increase ...
Won Eun-Ji EJ Department of Biological Sciences, College of Science, Sungkyunkwan University, Suwon 440-746, South - - 2014
Ultraviolet (UV) radiation can become an ecological problem due to its deleterious impact on organisms. To evaluate the effects of UV radiation on the reproductive physiology and macromolecules in marine zooplankton, several doses of UV radiation were used to treat the copepod Paracyclopina nana, and we analyzed in vivo endpoints ...
Fernandes Fabrício F A FF Programa de Pós-Graduação em Farmacologia e Química Medicinal, Instituto de Ciências Biomédicas - Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ, - - 2014
Serotherapy against snakebite is often unavailable in some regions over Brazil, where people make use of plants from folk medicine to deal with ophidic accidents. About 10% of Combretum species have some ethnopharmacological use, including treatment of snakebites. We evaluated the ability of the extract of Combretum leprosum and its ...
Ma Dongyun D National Engineering Research Center for Wheat, Henan Agricultural University, Zhengzhou, Henan, China, 450002; Key Laboratory of Physiology, Ecology and Genetic Improve of Food Crops in Henan Province, Zhengzhou, Henan, China, - - 2014
Understanding the variance of antioxidant in wheat grain responses to irrigation and nitrogen (N) fertilizer management will improve the nutrient quality of wheat grain. Four N rates (0, 180, 240, and 300 kg ha(-1) ) combined with irrigation times (I0 , no irrigation; I1 , jointing time irrigation; I2 , jointing + flowering time ...
Samimi Mansooreh M Department of Gynecology and Obstetrics, School of Medicine, Kashan University of Medical Sciences, Kashan, - - 2014
We are aware of no study that examined the effects of omega-3 fatty acid supplementation on insulin metabolism and lipid profiles in gestational diabetes (GDM). This study was designed to assess the effects of omega-3 fatty acid supplementation on insulin concentrations and lipid profiles among pregnant women with GDM. This ...
Kumar Manoj - - 2014
Density functional theory calculations predict that the gas-phase decomposition of carbonic acid, a high energy, 1,3-hydrogen atom transfer reaction, can be catalyzed by a monocarboxylic acid or a dicarboxylic acid, including carbonic acid itself. Carboxylic acids are found to be more effective catalysts than water. Among the carboxylic acids, the ...
Freund-Levi Yvonne Y Divisions of Clinical Geriatrics, Karolinska Institutet, Karolinska University Hospital at Huddinge, Stockholm, - - 2014
Background: Oxidative stress and inflammation are two key mechanisms suggested to be involved in the pathogenesis of Alzheimer's disease (AD). Omega-3 fatty acids (ω-3 FAs) found in fish and fish oil have several biological properties that may be beneficial in AD. However, they may also auto-oxidize and induce in vivo ...
Könczöl Arpád A Compound Profiling Laboratory, Gedeon Richter Plc., H-1475 Budapest, - - 2014
Oxybaphus nyctagineus (Michx.) Sweet has traditionally been used by several Native American tribes predominantly as a topical anti-inflammatory and analgesic agent. To evaluate the antioxidant, analgesic and anti-inflammatory activity of the extracts prepared from the aerial parts of O. nyctagineus and to characterize the major chemical constituents of the bioactive ...
Genovese Salvatore S Dipartimento di Farmacia, Università "G. d'Annunzio" Chieti-Pescara, Via dei Vestini 31, 66100, Chieti Scalo, (CH), Italy, - - 2014
4'-Geranyloxyferulic (GOFA) and boropinic acid have been discovered during the last decade as interesting phytochemicals having valuable pharmacological effects as cancer chemopreventive, anti-inflammatory, neuroprotective, and anti-Helicobacter pylori agents. A reverse-phase HPLC-UV/Vis method for the separation and quantification of the title oxyprenylated ferulic acid derivatives in extracts obtained from peels of ...
Scheringer Martin M Institute for Chemical and Bioengineering, ETH Zürich, 8093 Zürich, Switzerland. Electronic address: - - 2014
In this discussion paper, the transition from long-chain poly- and perfluorinated alkyl substances (PFASs) to fluorinated alternatives is addressed. Long-chain PFASs include perfluoroalkyl carboxylic acids (PFCAs) with 7 or more perfluorinated carbons, perfluoroalkyl sulfonic acids (PFSAs) with 6 or more perfluorinated carbons, and their precursors. Because long-chain PFASs have been ...
Bellido Carolina C Department of Chemical Engineering and Environmental Technology, University of Valladolid, Dr. Mergelina s/n, 47011 Valladolid, - - 2014
ABE fermentation by Clostridium beijerinckii of steam-exploded and ozonated wheat straw hydrolysates was investigated. In steam-exploded hydrolysates, highest yields of 0.40g/g ABE yield and 127.71gABE/kg wheat straw were achieved when the whole slurry from the pretreatment was used. In ozonated hydrolysates, 0.32g/g ABE yield and 79.65gABE/kg wheat straw were obtained ...
Zhang Weichao - - 2014
In this paper, for the hydrogen abstraction reaction of HCHO by OH radicals assisted by water, formic acid or sulfur acid, the possible reaction mechanisms and kinetics have been investigated theoretically using quantum chemistry methods and transition state theory. The potential energy surfaces calculated at the CCSD(T)/6-311++G(df,pd)//MP2(full)/6-311++G(df,pd) levels of theory ...
Tischer Alexander A Division of Hematology, Departments of Internal Medicine, Biochemistry and Molecular Biology, Mayo Clinic, Rochester, Minnesota, - - 2014
The ionic liquid 1-ethyl-3-methyl imidazolium chloride (EMIM Cl) and the amino acid l-ArgHCl have been successfully used to improve the yield of oxidative refolding for various proteins. However, the molecular mechanisms behind the actions of such solvent additives - especially of ionic liquids - are still not well understood. In ...
Stadler Jens M JM Interfaculty Institute of Biochemistry, Auf der Morgenstelle 15. and University of Tübingen, 72076 Tübingen, Germany. - - 2014
Applying psoralen interstrand crosslinks for the photoactivation of nucleic acids is a new concept. To find chromophores that can efficiently stimulate crosslink repair we screened several pyrenes and appended them to peptide nucleic acids for their site-selective addressing. Even though pyrenes conjugated to uracil revealed desirable spectroscopic properties they were ...
Gómez Diego A DA Department of Agricultural Chemistry, Facultad de Ciencias, Universidad Autónoma de Madrid, Carretera Colmenar Viejo km 15, 28049 Madrid, Spain. Electronic address: - - 2014
The effect of NAA (1-naphthaleneacetic acid) on organic acid exudation in white lupin plants grown under phosphorus deficiency was investigated. Plants were sampled periodically for collecting of organic acids (citrate, malate, succinate), and also were used to study the effect on proton extrusion and release of Na(+), K(+), Ca(2+) and ...
Ravasio Davide D Carlsberg Laboratory, Yeast Genetics, Gamle Carlsberg Vej 10, DK-1799, Copenhagen V, - - 2014
Aroma alcohols of fermented food and beverages are derived from fungal amino acids catabolism via the Ehrlich Pathway. This linear pathway consists of three enzymatic reactions to form fusel alcohols. Regulation of some of the enzymes occurs on the transcriptional level via Aro80. The riboflavin overproducer Ashbya gossypii produces strong ...
Prochaska Krystyna K Poznan University of Technology, Institute of Chemical Technology and Engineering, pl. M. Skłodowskiej-Curie 2, 60-965 Poznań, Poland. Electronic address: - - 2014
A novel approach based on a hybrid system allowing nanofiltration, bipolar electrodialysis and reactive extraction, was proposed to remove fumaric acid from fermentation broth left after bioconversion of glycerol. The fumaric salts can be concentrated in the nanofiltration process to a high yield (80-95% depending on pressure), fumaric acid can ...
Umadevi P P Department of Physics, Bharathiar University, Coimbatore 641 046, Tamil Nadu, - - 2014
In this work, using ab initio and density functional theory (DFT) methods halogen substituted formic acid (FA) dimer is studied. The dimer stability is due to the hydrogen bonds, either conventional (OH⋯O, OH⋯F, OH⋯Cl) or non-conventional (CH⋯O, CH⋯F, CH⋯Cl). Among all the dimers, trans-trans form is more stable than the ...
Zhou Alice Qinhua AQ Department of Molecular Biophysics & Biochemistry, Yale University, New Haven, CT, USA; Integrated Graduate Program in Physical and Engineering Biology (IGPPEB), Yale University, New Haven, CT, USA; Howard Hughes Medical Institute International Research - - 2014
The side-chain dihedral angle distributions of all amino acids have been measured from myriad high-resolution protein crystal structures. However, we do not yet know the dominant interactions that determine these distributions. Here, we explore to what extent the defining features of the side-chain dihedral angle distributions of different amino acids ...
Senol F Sezer - - 2014
Current evidence suggests that endogenous dopamine may act as a neurotoxin following its oxidation to an o-quinone and reaction with cellular thiols, which are neutoxic, which may occur spontaneously or via reaction with tyrosinase or some other enzymes. Tyrosinase (E.C. 1.14.18.1) with two cupper ions coordinated by three histidines is ...
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