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Utrilla M C MC Department of Analytical Chemistry and Food Technology, Faculty of Sciences and Technologies Chemistries, University of Castilla-La Mancha, Avda. Camilo José Cela s/n, 13071 Ciudad Real, Spain; Regional Institute for Applied Scientific Research (IRICA), University of Castilla-La Mancha, Avda Camilo José Cela s/n, 13071 Ciudad Real, - - 2014
The minimum percentage of pork meat to be added to traditional venison salchichon has been determined in order to ensure a nutritionally healthier product without impairing physicochemical or sensory properties. Six types of salchichon were made using lean venison and a varying amount of pork meat (40%, 30%, 25%, 20%, ...
Güngör Irfan I Department of Anesthesiology and Reanimation, Medical Faculty of Gazi University, 06500 Beşevler, Ankara, Turkey. - - 2014
In this study, we aimed to study the anti-apoptotic effects of hyaluronic acid on the apoptotic effects of bupivacaine in cultured rat chondrocytes in a time and dose-dependent manner. The rat chondrocytes were treated with 7.69 µM, 76.9 µM, and 384.5 µM bupivacaine and 50 µg/ml hyaluronic acid concentrations for ...
Oyedeji Opeoluwa O OO Department of Chemistry, University of Fort Hare, Alice, South Africa ooyedeji@ufh.ac.za - - 2014
Oleanolic acid is a triterpenoid that has shown in vitro cytotoxic activity against human tumour cells and is known to be present in many higher plants. Oleanolic acid is known to have some biological potential including anticancer property. Oleanolic acid was isolated from the ethyl acetate fraction of Syzygium aromaticum ...
Van Hauwenhuyse Frédérique F Department of Molecular Microbiology, VIB, Leuven, Belgium Laboratory of Molecular Cell Biology, KU Leuven, Kasteelpark Arenberg 31 bus 2438, 3001 Leuven, - - 2014
Morphogenetic transitions of the opportunistic fungal pathogen Candida albicans are influenced by temperature changes, with induction of filamentation upon a shift from 30 to 37°C. Hsp90 was identified as a major repressor of an elongated cell shape morphology at low temperatures, as treatment with specific inhibitors of Hsp90 results in ...
Kim Hye-In HI Department of Pharmaceutical Science, College of Pharmacy, Kyung Hee University, 26 Kyung-Heedaero, Seoul 130-701, Republic of - - 2014
Extracts of Prunella vulgaris have been shown to exert antiestrogenic effects. To identify the compounds responsible for these actions, we isolated the constituents of P. vulgaris and tested their individual antiestrogenic effects. Rosmarinic acid, caffeic acid, ursolic acid (UA), oleanolic acid, hyperoside, rutin and betulinic acid (BA) were isolated from ...
Li Ying Y College of Sciences, Nanjing Agricultural University , Nanjing, P.R. China - - 2014
Cu(II) catalytic reduction of Cr(VI) by tartaric acid under the irradiation of simulated solar light was investigated through batch experiments at pHs from 3 to 6 and at temperatures from 15°C to 35°C. Results demonstrated that introduction of Cu(II) could markedly improve reduction of Cr(VI) in comparison with tartaric acid ...
Aarak K E KE Department of Chemistry-, Biotechnology and Food Science, UMB, Ås, - - 2014
The aim of the present work was to study the effect of a broccoli phytochemical extract (Br-ex) on the release of fatty acids (FA) from salmon muscle (SM) and salmon oil (SO) during in vitro digestion. The hypothesis of the study was that Br-ex contains polyphenols which might act as ...
Huang Qiang - - 2014
Graphene oxide and its derivative have attracted extensive interests in many fields including catalytic chemistry, organic synthesis and electrochemistry recently. We explored whether the use of graphene after chemical modification with amino acids to immobilize copper nanoparticles could achieve a more excellent catalytic activity for N-arylation reactions. A facile and ...
Chang Dong D a First Affiliated Hospital of the Harbin Medical University , Harbin , - - 2014
Purpose: To evaluate and compare the levels of free fatty acids between senile cataract patients and normal controls. Methods: Fifty consecutive patients with newly diagnosed senile cataract and 50 age- and gender-matched controls were evaluated. Subjects/patients were randomized according to selection criteria. The levels of free fatty acids (FFAs) in ...
Xu Jian J The Key Laboratory of Industrial Biotechnology, Ministry of Education, School of Biotechnology, Jiangnan University, 1800 Lihu Road, Wuxi, 214122, - - 2014
An integrated citric acid-methane fermentation process was proposed to solve the problem of extraction wastewater in citric acid fermentation process. Extraction wastewater was treated by anaerobic digestion and then recycled for the next batch of citric acid fermentation to eliminate wastewater discharge and reduce water resource consumption. Acetic acid as ...
Kikuchi Mari M Department of Biochemical Engineering, Graduate School of Science and Technology, Yamagata University , Yonezawa, Yamagata 9928510, - - 2014
Total synthesis of callipeltins B and M, peptidyl cytotoxic agents isolated from marine sponges, by the combination of Fmoc solid-phase peptide synthesis and cyclization and global deprotection in the solution phase is described. Eight amino acids, including several unusual amino acids, were assembled on a solid support, and effective TFA-mediated ...
Rogers Michael A - - 2014
The bioaccessibility of salicylic acid (SA) can be effectively modified by incorporating the pharmacological compound directly into poly(anhydride-esters) of salicylic acid (SADG-P) and salicylic acid diglycolylic acid (SADG). After simulated digestion conditions, the bioaccessibility of SA was observed to be statistically different (p<0.0001) in each sample: 40.3 ± 2.0 % ...
Hu Huiqing H State Key Laboratory of Food Science and Technology, School of Environmental and Civil Engineering, Jiangnan University, Wuxi, 214122, - - 2014
To explore how lead (Pb) and acid rain simultaneously affect plants, the combined effects of Pb and acid rain on the chlorophyll content, chlorophyll fluorescence reaction, Hill reaction rate, and Mg(2+)-ATPase activity in soybean seedlings were investigated. The results indicated that, when soybean seedlings were treated with Pb or acid ...
Stanley Jill J School of Biomolecular and Physical Science, Griffith University, Nathan, QLD 4111, Australia and The New Zealand Institute for Plant & Food Research Ltd, RD 1, Alexandra 9391, New - - 2014
Improving apricot fruit quality delivered to consumers is key to ensuring a successful apricot industry. Previous studies have focused on effects of either soluble solids content (SSC) or fruit firmness on consumer preferences and results have been equivocal. This study evaluated the effects of crop load and harvest maturity, how ...
Chen Si S Divisions of Biochemical Toxicology; National Center for Toxicological Research/ U.S. FDA, Jefferson, AR - - 2014
The use of usnic acid and usnic acid containing products is associated with acute liver failure; however, mechanistic studies of hepatotoxicity caused by usnic acid are limited. In this study, we investigated and characterized the possible mechanisms, especially the role of autophagy in usnic acid's toxicity in human HepG2 cells. ...
Heesen M M Department of Anaesthesia, Klinikum Bamberg, Bamberg, - - 2014
Tranexamic acid is effective in reducing blood loss during various types of surgery and after trauma. No compelling evidence has yet been presented for post-partum haemorrhage. A systematic literature search of relevant databases was performed to identify trials that assessed blood loss and transfusion incidence after tranexamic acid administration for ...
Cardenas Javier J Department of Chemical Engineering and Materials Science, University of California, Irvine, CA, 92697-2575 - - 2014
Biobased chemicals have become attractive replacements for their fossil-fuel counterparts. Recent studies have shown triacetic acid lactone (TAL) to be a promising candidate, capable of undergoing chemical conversion to sorbic acid and other valuable intermediates. In this study, Saccharomyces cerevisiae was engineered for the high-level production of TAL by overexpression ...
Kumar Muthukannan Satheesh MS Division of Microbial Biodiversity and Bioenergy, Department of Microbiology, School of Life Sciences, Bharathidasan University, Tiruchirappalli, 620 024, Tamil Nadu, India; Department of Environmental Engineering, Yonsei University, Wonju, 220 710, Republic of - - 2014
The study investigated the effect of pesticide chlorpyrifos on a freshwater cyanobacterium Chroococcus turgidus NTMS12. The changes in chlorophyll-a, proline, superoxide dismutase, catalase activities and fatty acids composition of the test organism were analyzed. Organism was grown at 6, 9 and 12 mg l(-1) of chlorpyrifos and based on the ...
Nozzi Nicole E NE Department of Chemistry, University of California, Davis, One Shields Ave, Davis, CA, 95616, - - 2014
Engineering microbial hosts for the production of higher alcohols looks to combine the benefits of renewable biological production with the useful chemical properties of larger alcohols. In this review we outline the array of metabolic engineering strategies employed for the efficient diversion of carbon flux from native biosynthetic pathways to ...
Choi Jin Wook JW Department of Chemical Engineering and Materials Science, University of California, Irvine, CA, 92697-2575 - - 2014
Polyketides and fatty acids are important in the production of pharmaceuticals, industrial chemicals, and biofuels. The synthesis of the malonyl-CoA building block, catalyzed by acetyl-CoA carboxylase (Acc1), is considered a limiting step to achieving high titers of polyketides and fatty acids in Saccharomyces cerevisiae. Acc1 is deactivated by AMP-activated serine/threonine ...
Jung Bahngmi B Chemical Engineering Program, Texas A&M University at Qatar, Education City, PO Box 23874, Doha, Qatar. Electronic address: - - 2014
The introduction of nanoscale zero valent iron (nZVI) into the subsurface has recently received significant attention as a potentially effective method for remediation of source zones of chlorinated solvents present as dense nonaqueous phase liquids (DNAPL). One of the challenges in the deployment of nZVI is to achieve good subsurface ...
Becker Axel - - 2014
Valerian is commonly used for the treatment of insomnia and anxiety. Valerian extracts allosterically modulate GABA-A receptors and induced an anxiolytic activity. This activity is closely related to valerenic acid. In the present experiments it was investigated whether acetoxy valerenic acid may interfere with the anxiolytic action of valerenic acid. ...
Hou Xue-Dan XD State Key Laboratory of Pulp and Paper Engineering, College of Light Industry and Food Sciences, South China University of Technology, Guangzhou 510640, China; College of Biosciences and Bioengineering, South China University of Technology, Guangzhou 510006, - - 2014
In this work, 28 cholinium ILs, most of which are good solvents for dissolving lignin, were used for rice straw pretreatment to improve subsequent enzymatic hydrolysis. The anion exerted a significant effect on the pretreatment effectiveness of the IL as well as the subsequent enzymatic hydrolysis efficiency of rice straw ...
Paczkowski Melissa M M Paczkowski, Research, National Foundation for Fertility Research, Lone Tree, United - - 2014
Fatty acid oxidation (FAO) is essential for oocyte maturation in mice. The objective of this experiment was to determine the effect of etomoxir (a FAO inhibitor; 100 μM), carnitine (1 mM), and palmitic acid (1 or 100 μM) during maturation on metabolism and gene expression of the oocyte and cumulus ...
Moro Artur J - - 2014
The kinetics and thermodynamics of the 2,6-bis(2-hydroxybenzilidene)cyclohexanone chemical reactions network was studied at different pH values using NMR, UV-Vis, continuous irradiation and flash photolysis. The chemical behavior of the system partially resembles with anthocyanins and their analogue compounds. 2,6-Bis(2-hydroxybenzilidene)cyclohexanone exhibits slow color change from yellow to red styrylflavylium under extreme ...
Maddipati Krishna Rao KR Bioactive Lipids Research Program, Department of Pathology, Lipidomics Core Facility, and Department of Obstetrics and Gynecology, Wayne State University School of Medicine, Detroit, Michigan, USA;Bioactive Lipids Research Program, Department of Pathology, Lipidomics Core Facility, and Department of Obstetrics and Gynecology, Wayne State University School of Medicine, Detroit, Michigan, USA; - - 2014
Lipid mediators play an important role in reproductive biology, especially, in parturition. Enhanced biosynthesis of eicosanoids, such as prostaglandin E2 (PGE2) and PGF2α, precedes the onset of labor as a result of increased expression of inducible cyclooxygenase 2 (COX-2) in placental tissues. Metabolism of arachidonic acid results in bioactive lipid ...
Chen Xiulai X State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi 214122, China; Key Laboratory of Industrial Biotechnology, Ministry of Education, Jiangnan University, Wuxi 214122, China; Laboratory of Food Microbial-Manufacturing Engineering, Jiangnan University, Wuxi 214122, - - 2014
A multi-vitamin auxotrophic Torulopsis glabrata strain, a pyruvate producer, was further engineered to produce fumaric acid. Using the genome-scale metabolic model iNX804 of T. glabrata, four fumaric acid biosynthetic pathways, involving the four cytosolic enzymes, argininosuccinate lyase (ASL), adenylosuccinate lyase (ADSL), fumarylacetoacetase (FAA) and fumarase (FUM1), were found. Athough single ...
Sanematsu Keisuke K Kyushu University, - - 2014
Gymnemic acids are triterpene glycosides that selectively suppress taste responses to various sweet substances in humans, but not in mice. This sweet-suppressing effect of gymnemic acids is diminished by rinsing the tongue with γ-cyclodextrin (γ-CD). However, little is known about the molecular mechanisms underlying sweet-suppressing effect of gymnemic acids and ...
Gou Qian Q Dipartimento di Chimica "G. Ciamician", Università di Bologna, Via Selmi 2, I-40126 Bologna (Italy), Fax: - - 2014
We report the rotational spectra of two conformers of the acetic acid-difluoroacetic acid adduct (CH3 COOH-CHF2 COOH) and supply information on its internal dynamics. The two conformers differ from each other, depending on the trans or gauche orientation of the terminal CHF2 group. Both conformers display splittings of the rotational ...
Kowshika J - - 2014
Background: Blocking vascular endothelial growth factor (VEGF) mediated tumor angiogenesis by phytochemicals has emerged as an attractive strategy for cancer prevention and therapy. Methods: We investigated the anti-angiogenic effects of ellagic acid in a hamster model of oral oncogenesis by examining the transcript and protein expression of hypoxia-inducible factor-1alpha (HIF-1a), ...
Allen Scott E - - 2014
The N-heterocyclic carbene and hydroxamic acid co-catalyzed kinetic resolution of cyclic amines generates enantioenriched amines and amides with selectivity factors up to 127. In this report, a quantum mechanical study of the reaction mechanism indicates that the selectivity-determining aminolysis step occurs via a novel concerted pathway in which the hydroxamic ...
Fang Weiwei W Department of Chemistry, Fudan University, 220 Handan Road, 200433, Shanghai, China. - - 2014
By using metallo-hydrogel as a new platform, a simple and straightforward selective visual discrimination of cysteine, homocysteine and glutathione from each other as well as from other amino acids has been realized.
Gondor Orsolya Kinga OK Agricultural Institute, Centre for Agricultural Research, Hungarian Academy of Sciences, H-2462 Martonvásár, POB 19, - - 2014
UV-B radiation may have either a positive or negative impact under the same conditions in wheat, depending on the type of secondary abiotic stressor: Cd or drought. Supplemental UV-B prevented the wilting and leaf rolling induced by PEG treatment. In contrast, combined UV-B and Cd treatment resulted in pronounced oxidative ...
Inada Takefumi T Department of Anesthesiology, Kansai Medical University , Osaka , - - 2014
Abstract Propofol is an intravenous drug widely used for anesthesia and sedation. Previously, propofol was shown to inhibit cyclo-oxygenase (COX) and 5-lipoxygenase (5-LOX) activities. Because these enzyme-inhibiting effects have only been demonstrated in vitro, this study sought to ascertain whether similar effects might also be observed in vivo. In the ...
Kelley Nirvair S NS 1 Arizona College of Osteopathic Medicine, Midwestern University , Glendale, - - 2014
Abstract Background: Despite many known health benefits of n-3 polyunsaturated fatty acids (PUFA), there is a concern that their high degree of unsaturation may actually increase oxidative stress, lipid peroxidation (LPO), and chronic inflammatory diseases. Methods: In this review, we have analyzed results from published human studies regarding the effects ...
Liljeblad Jonathan F D JF School of Chemistry, Division of Surface and Corrosion Science, KTH Royal Institute of Technology, SE-100 44 Stockholm, Sweden. - - 2014
The morphology and molecular conformation of Langmuir-Blodgett deposited and floating monolayers of a selection of straight chain (eicosanoic acid, EA), iso (19-methyl eicosanoic acid, 19-MEA), and anteiso (18-methyl eicosanoic acid, 18-MEA) fatty acids have been investigated by Vibrational Sum Frequency Spectroscopy (VSFS), AFM imaging, and the Langmuir trough. While the ...
Chen Rui R State Key Laboratory of Biomembrane and Membrane Biotechnology, Tsinghua University-Peking University Joint Center for Life Sciences, School of Life Sciences, Tsinghua University, Beijing 100084, - - 2014
Organisms have evolved elaborate mechanisms to adjust intracellular nutrient levels in response to fluctuating availability of exogenous nutrients. During starvation, cells can enhance amino acid uptake and synthesis through the general amino acid control (GAAC) pathway, whereas nonessential cellular contents are recycled by autophagy. How these two pathways are coordinated ...
Luo Xu-Ying XY State Key Laboratory of Food Science and Technology, Nanchang Univ, Nanchang, 330047, China; Engineering Research Center of Biomass Conversion, Ministry of Education, Nanchang Univ, Nanchang, 330047, - - 2014
To identify inhibitors for lysinoalanine formation in preserved egg, sulfhydryl compounds (glutathione, L-cysteine), carbohydrates (sucrose, D-glucose, maltose), organic acids (L-ascorbic acid, citric acid, DL-malic acid, lactic acid), and sodium sulfite were individually added at different concentrations to a pickling solution to prepare preserved eggs. Lysinoalanine formation as an index of ...
Wakashima Takeshi T Hokkaido University, - - 2014
The sphingolipid metabolite sphingosine-1-phosphate (S1P) functions as a lipid mediator and as a key intermediate of the sole sphingolipid-to-glycerophospholipid metabolic pathway (S1P metabolic pathway). In this pathway, S1P is converted to palmitoyl-CoA through 4 reactions, then incorporated mainly into glycerophospholipids. Although most of the genes responsible for the S1P metabolic ...
Jang Eungyeong - - 2014
Artemisia capillaris (AC) has been recognized as one of the promising candidates for hepatoprotective, hypoglycemic, hypolipidemic, antiobesitic and anti-inflammatory therapeutic effectiveness. This study evaluated the inherent mechanism and anti-apoptotic activity of 30% ethanol extract of AC (AC extract) 100 mug/ml on free fatty acids (FFAs)-induced HepG2 cellular steatosis and lipoapoptosis. ...
Arunagiri Pandiyan P Department of Biochemistry and Biotechnology, Faculty of Science, Annamalai University, Annamalainagar, Tamil Nadu, 608 002, - - 2014
Manic episode in bipolar disorder (BD) was evaluated in the present study with supplementation of omega-3 fatty acids in combination with aripiprazole and lithium on methylphenidate (MPD)-induced manic mice model. Administration of MPD 5 mg/kg bw intraperitoneally (i.p.) caused increase in oxidative stress in mice brain. To retract this effect, supplementation ...
van Beilen J W A JW Molecular Biology & Microbial Food Safety, Swammerdam Institute for Life Sciences, University of Amsterdam, The - - 2014
Sorbic and acetic acid are amongst the most commonly used weak organic acid preservatives to improve the microbiological stability of foods. Both have a similar pKa value but sorbic acid is a far more potent preservative. Weak organic acids are most effective at low pH. Under these circumstances, they are ...
Dolce Vincenza V Department of Pharmacy, Health and Nutritional Sciences, University of Calabria, Arcavacata di Rende Cosenza, - - 2014
The citrate carrier (CiC), characteristic of animals, and the dicarboxylate-tricarboxylate carrier (DTC), characteristic of plants and protozoa, belong to the mitochondrial carrier protein family whose members are responsible for the exchange of metabolites, cofactors, and nucleotides between the cytoplasm and the mitochondrial matrix. Most of the functional data on these ...
Torres-Contreras Ana Mariel - - 2014
Potato tubers under wounding stress synthesize chlorogenic acid isomers, which are phenolic compounds that prevent chronic diseases. Phenolic compounds biosynthesis in plants requires aromatic amino acids that are produced from sugars. Therefore, in the present study, we hypothesized that the wound-induced accumulation of chlorogenic acid isomers in potatoes could be ...
Ruan Weimei W a Department of Chemistry , National University of Singapore , Singapore , - - 2014
The response surface methodology was used to optimise the extraction conditions of Ganoderma lucidum based on a Box-Behnken design. A quadratic model sufficiently simulated the response of ganoderic acid H with a determination coefficient (R(2)) of 0.98. The optimal condition for extracting triterpenoids was determined to be 100.00% ethanol at ...
Honcharenko Dmytro D Department of Biosciences and Nutrition, Karolinska Institutet, S-14183 Huddinge, Sweden. Roger.Stromberg@ki.se - - 2014
Peptide-like compounds containing an arginine have been shown to bind and stabilize the central helix of the Alzheimer's disease related amyloid-β peptide (Aβ) in an α-helical conformation, thereby delaying its aggregation into cytotoxic species. Here we study a novel Aβ targeting ligand AEDabDab containing the triamino acid, N(γ)-(2-aminoethyl)-2,4-diaminobutanoic (AEDab) acid. ...
Bartkiene Elena E Lithuanian University of Health Sciences, Tilzes str. 18, 47181, Kaunas, - - 2014
The ability of bacteriocin-like inhibitory substances (BLIS) producing lactic acid bacteria to degrade biogenic amines as well as to produce L(+) and D(-)-lactic acid during solid state fermentation (SSF) of lupine and soybean was investigated. In addition, the protein digestibility and formation of organic acids during SSF of legume were ...
Sun Xinxiao X State Key Laboratory of Chemical Resource Engineering, Beijing University of Chemical Technology, Beijing, China - - 2014
Non-oxidative decarboxylases belong to a unique enzyme family that does not require any cofactors. Here we report the characterization of a 2,3-dihydroxybenzoic acid (2,3-DHBA) decarboxylase (BDC) from Klebsiella pneumoniae and explore its application on the production of muconic acid. The enzyme properties were systematically studied, including the optimal temperature and ...
Fernández-Galilea Marta M Department of Nutrition, Food Science and Physiology, University of Navarra, Pamplona, - - 2014
α-Lipoic acid (α-LA) is a natural occurring antioxidant with beneficial effects on obesity. The aim of this study was to investigate the putative effects of α-LA on triglyceride accumulation and lipogenesis in subcutaneous adipocytes from overweight/obese subjects and to determine the potential mechanisms involved. Fully differentiated human subcutaneous adipocytes were ...
Flock Michael R MR Department of Nutritional Sciences, The Pennsylvania State University, University Park, PA, 16802, United - - 2014
The long-chain omega-3 polyunsaturated (n-3 PUFA), eicosapentaenoic (EPA) and docosahexaenoic acid (DHA), may have anti-inflammatory effects. We evaluated the dose-response effect of EPA+DHA supplementation on circulating TNF-α, IL-6, and CRP and explored associations between red blood cell (RBC) membrane PUFA content and TNF-α, IL-6, and CRP. Young adults with low ...
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