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Results 601 - 650 of 3659
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Wisastra Rosalina - - 2013
Lipoxygenases (LOXs) and cyclooxygenases (COXs) metabolize poly-unsaturated fatty acids into inflammatory signaling molecules. Modulation of the activity of these enzymes may provide new approaches for therapy of inflammatory diseases. In this study, we screened novel anacardic acid derivatives as modulators of human 5-LOX and COX-2 activity. Interestingly, a novel salicylate ...
Bertin Matthew J - - 2013
Harmful algal blooms (HABs) expose aquatic organisms to multiple physical and chemical stressors during an acute time period. Algal toxins themselves may be altered by water chemistry parameters affecting their bioavailability and resultant toxicity. The purpose of this study was to determine the effects of two abiotic parameters (pH, inorganic ...
Chen Wei - - 2013
Patients with gout have lower calcitriol levels that improve when uric acid is lowered. The mechanism of these observations is unknown. We hypothesized that uric acid inhibits 1-αhydroxylase. In vivo, Sprague Dawley rats were randomized to control (n=5), allantoxanamide (n=8), febuxostat (n=5), or allantoxanamide+febuxostat (n=7). Vitamin D, PTH, and 1-αhydroxylase ...
Xiao Xirui - - 2013
The entire fatty acid biosynthetic pathway from Escherichia coli, starting from the acetyl-CoA carboxylase, has been reconstituted in vitro from fourteen purified protein components. Radiotracer analysis verified stoichiometric conversion of acetyl-CoA and NAD(P)H into the free fatty acid product, allowing implementation of a facile spectrophotometric assay for kinetic analysis of ...
Guo Rongfang - - 2013
The interplay of plant hormones and glucose (Glu) in regulating glucosinolate accumulation in Arabidopsis thaliana was investigated in this study. Glucose-induced glucosinolate biosynthesis was enhanced significantly by the addition of jasmonic acid (JA), whereas the synergistic effect of salicylic acid (SA) and Glu was less obvious. The enhanced glucosinolate accumulation ...
Sooksawat Dhassida - - 2013
We report that the acid-base induced changes to a cyclometallated platinum complex can be used to drive the exchange of accompanying ligands with different denticities.
Brewster Timothy P - - 2013
A series of half-sandwich Ir and Rh compounds are demonstrated to be competent catalysts for the hydrogenation of carboxylic acids under relatively mild conditions. Of the structurally diverse group of catalysts tested for activity, a Cp*Ir complex supported by an electron-releasing 2,2'-bipyridine ligand was the most active. Higher activity was ...
Dumitru Liviu Mihai - - 2013
We report the use of a polyanionic proton conductor, poly(acrylic acid) PAA, to gate a poly(2,5-bis(3-tetradecylthiophen-2-yl)thienol[3,2-b]thiophene) pBTTT-C14 based Organic Field-Effect Transistor (OFET). A planar configuration of the OFET was evaluated and the electrical performances as well as the implementation on flexible substrates will be discussed.
Mba Miriam - - 2013
Light-responsive vesicles: Derivatives of an α-amino acid with two azobenzene side chains self-assemble into vesicular structures that undergo morphological transitions upon light irradiation. This is the first example of photoresponsive vesicle-like supramolecular structures formed exclusively by peptides or derivatized amino acids. The entrapment and subsequent light-induced release of functionalized gold ...
Saw Constance Lay Lay - - 2013
Oxidative stress is a major driver of many diseases, including cancer. The induction of Nrf2-ARE-mediated antioxidant enzymes provides a cellular defense against oxidative stress. Astaxanthin (AST), a red dietary carotenoid, possesses potent antioxidant activity, and inhibits oxidative damages. Polyunsaturated fatty acids (PUFAs), docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA), are ...
Afitlhile Meshack - - 2013
Previous studies have shown that a mutant of Arabidopsis that lacks the Toc159 receptor is impaired in chloroplast biogenesis. The mutant is referred as plastid protein import 2 or ppi2 and has an albino phenotype due to its inability to import the photosynthetic proteins. In this study, we measured fatty ...
Winkler H H Fraunhofer Institute for Applied Polymer Research, Division Biopolymers, Department Starch/Biotechnological Processes, Geiselbergstr. 69, 14476 Potsdam, Germany. Electronic address: - - 2014
The current study examined thermal and mechanical properties of fatty acid starch esters (FASEs). All highly soluble esters were obtained by the sustainable, homogeneous transesterification of fatty acid vinyl esters in dimethylsulfoxide (DMSO). Casted films of products with a degree of substitution (DS) of 1.40-1.73 were compared with highly substituted ...
Zhang Hao - - 2013
Dephosphorylation reactions of phosphoprotein phosphatases (PPPs) share a common catalytic cycle. In one stage of the cycle, the active site is regenerated through formation of a new nucleophilic μ-hydroxy moiety and reprotonation of the proton donor, His125 (numbered according to the protein phosphatase 1 sequence). To date the exact details ...
Torzewska Agnieszka - - 2013
Infectious urolithiasis is a consequence of persistent urinary tract infections caused by urease producing bacteria e.g. Proteus mirabilis. These stones are composed of struvite and carbonate apatite. Their rapid growth and high recurrence indicate that so far appropriate methods of treatment have not been found. In the present study, the ...
Carbonera Fabiana - - 2014
This study evaluated the effect of the dietary replacement of sunflower oil with perilla oil in Nile tilapia (GIFT strain) at 0, 10, 20 and 30days. There was an increase in total omega 3 fatty acids (n-3) in muscle tissue (from 63.6 to 181.5mgg(-1)) and a decrease in total concentration ...
Cheerlavancha Raju - - 2013
Backbone-homologated amino acids have been synthesized, containing three vicinal fluorine atoms placed stereospecifically along the carbon chain. Different trifluoro stereoisomers are found to have contrasting conformations, consistent with known stereoelectronic effects associated with C-F bonds.
Costentin Cyrille - - 2013
A detailed cyclic voltammetric investigation of the reduction of moderately weak acids on platinum reveals that they are reduced in two steps, one involving the hydrated protons initially present at equilibrium and the second the reduction of the acid through its prior conversion into hydrated protons. The reduction of pyridinium ...
Schuster Gertrud U - - 2013
ABSTRACT While the effects of fish oil supplements on airway inflammation in asthma have been studied with varying results, the independent effects of the fish oil components, eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), administered separately are untested. Objective/ Methods: Here we investigated airway inflammation and hyper-responsiveness using a mouse ...
Maitin Vatsala - - 2013
One mechanism of the lipid-lowering effects of the fish oil n-3 fatty acids (e.g., docosahexaenoic acid; DHA) in cell and animal models is induced hepatic apolipoprotein B100 (apoB) pre-secretory degradation. This degradation occurs post-ER, but whether DHA induces it prior to or after intracellular VLDL formation remains an open question. ...
Xu Wen-Ai - - 2013
Rhizoma Smilacis Glabrae (RSG) has been used in the clinical treatment of gout and hyperuricemia in China for thousands of years. Modern pharmacological studies have shown that RSG exhibits hypouricemic effects because of its significant inhibitory effect on the activity of xanthine oxidase. The Rhizoma Smilacis Glabrae extract (RSGE) at ...
Bordessa Andrea - - 2013
We describe the synthesis of a library of new pseudopeptides and their inhibitory activity of the rabbit 20S proteasome chymotrypsin-like (ChT-L) activity. We replaced a natural α-amino acid by an α- or a β-hydrazino acid and obtained inhibitors of proteasome up to a submicromolar range (0.7 μM for molecule 24b). Structural ...
Xue Feng - - 2013
An efficient rhodium/olefin-sulfoxide catalyzed asymmetric conjugate addition of organoboronic acids to various unsaturated esters has been developed, where 2-methoxy-1-naphthyl sulfinyl functionalized olefin ligands have been shown to be highly effective, and are especially applicable to unsaturated methyl esters with up to 99% yield and 91% ee.
Gray B - - 2013
An increase in adiposity is associated with altered levels of biologically active proteins. These include the hormones adiponectin and leptin. The marked change in circulating concentrations of these hormones in obesity has been associated with the development of insulin resistance and metabolic syndrome. Variations in dietary lipid consumption have also ...
Digennaro Angela - - 2013
Oligothiophene-proline hybrids were synthesized via click-reaction showing intriguing self-assembly behavior in an aqueous environment by forming chiral superstructures, whose helicity is controlled by the configuration of the amino acid moiety.
Fang Guoyong - - 2013
Rapid atomic layer deposition (RALD) has been applied to prepare various nanolaminates with repeated multilayer structures. The possible reaction pathways for RALD of the Al2O3/SiO2 nanolaminate using trimethylaluminum (TMA) and tris(tert-butoxy)silanol (TBS) are investigated by using density functional theory (DFT) calculations. The introduction of a Lewis-acid catalyst, TMA, can result ...
Hwang Su Jung - - 2013
Chlorogenic acid, which belongs to the polyphenols, is an anti-oxidant and anti-obesity agent. In this study, we investigated the role of chlorogenic acid in inflammation. Anti-inflammatory effects of chlorogenic acid were examined in lipopolysaccharide (LPS)-stimulated murine RAW 264.7 macrophages and BV2 microglial cells. We observed the level of various inflammation ...
Emenike Bright U - - 2013
Substituent effects in N─H...O hydrogen bonds were estimated by comparing the acidities of two series of model compounds: N-benzoylanthranilic acids (A) and 4-benzoylamidobenzoic acids (B). Intramolecular N─H...O hydrogen bonds were found to be present in the A series of compounds, while B acids were used as control models. The respective ...
Hashimoto Takuya - - 2013
The synthetic utility of quinone imine ketals in the context of asymmetric catalysis was disclosed for the first time. By expanding the utility of chiral Brønsted acid catalysis to the electrophilic activation of quinone imine ketals, we succeeded in the development of highly enantioselective arylation of encarbamates to give α-amino-β-aryl ...
Itoh Masaki - - 2013
The dehydrogenative coupling of maleic acids with alkynes proceeds smoothly accompanied by decarboxylation under rhodium catalysis to produce variously substituted alpha-pyrone derivatives. The catalyst system is also applicable to the coupling with 1,3-diynes and alkenes.
Kubota Tadafumi - - 2013
Eicosapentaenoic acid (EPA) has beneficial effects in many inflammatory disorders. In this study, dietary EPA was converted to 17,18-epoxyeicosatetraenoic acid (17,18-EpETE) by ω-3 epoxygenation in the mouse peritoneal cavity. Mediator lipidomics revealed a series of novel oxygenated metabolites of 17,18-EpETE, and one of the major metabolites, 12-hydroxy-17,18-epoxyeicosatetraenoic acid (12-OH-17,18-EpETE), displayed ...
Ziemba Amy - - 2013
Together with ubiquitin ligases (E3s), ubiquitin-conjugating enzymes (E2s) are charged with the essential task of synthesizing ubiquitin chains onto protein substrates. Some 75 percent of the known E2s in the human proteome contain unique insertions in their primary sequences, yet it is largely unclear what effect these insertions impart on ...
Zheng Ruijin - - 2013
Nitric oxide and various by-products including nitrite contribute to tissue injury by forming novel intermediates via redox-mediated nitration reactions. Nitration of unsaturated fatty acids generates electrophilic nitrofatty acids such as 9-nitrooleic acid (9-NO) and 10-nitrooleic acid (10-NO), which are known to initiate intracellular signaling pathways. In these studies, we characterized ...
Sillerová Hana - - 2013
This work investigates the mechanisms behind Cr(VI) biosorption/reduction on three biomaterials (brewers draff, grape waste and synthetic humic acid). Coupled Cr isotope analysis with ICP-OES, XPS and SEM was tested as a novel approach to study the reduction of Cr(VI) by the biomaterials. The Cr(VI) biosorption process was accompanied with ...
Monteiro-Cardoso Vera F - - 2013
Cancer cells can adapt their metabolic activity under nutritional hostile conditions in order to ensure both bioenergetics and biosynthetic requirements to survive. In this study, the effect of glucose deprivation on Caco-2 cells bioenergetics activity and putative relationship with membrane lipid changes were investigated. Glucose deprivation induces a metabolic remodeling ...
Alvarez-Vasco Carlos - - 2013
This study investigated softwood hemicelluloses degradation pathways during alkaline hydrogen peroxide (AHP) pretreatment of Douglas fir. It was found that glucomannan is much more susceptible to alkaline pretreatment than xylan. Organic acids, including lactic, succinic, glycolic and formic acid are the predominant products from glucomannan degradation. At low treatment temperature ...
Hosseini Hedayat - - 2014
In this study, the influence of four cooking methods (baking, boiling, microwaving and frying) was evaluated on the nutritional value of kutum roach. Proximate, fatty acid composition, vitamin and mineral contents and also nutritional quality indices (NQI) of kutum roach were investigated before and after cooking treatment. All treated samples ...
Xu Yue - - 2013
Well-crystallized BiOCl nanoplates with exposed {001} facets were synthesized by a facile electrochemical anodic oxidation method. The thickness of the nanoplates decreases with increasing citric acid content in the electrolyte. The optical absorption edge of the BiOCl nanoplates shifts to a longer wavelength with citric acid. The BiOCl nanoplates obtained ...
Jabbar Saqib - - 2013
Abstract This study was conducted to evaluate the combined effects of blanching and sonication on carrot juice quality. Carrots were blanched at 100 °C for 4 min in normal and acidified water. Juice was extracted and sonicated at 15 °C for 2 min keeping pulse duration 5 s on and 5 s off (70% amplitude level ...
Wei Benxi - - 2013
The effect of defatting on the physiochemical properties and the acid hydrolysis rate of maize starch with different amylose contents was evaluated in this study. The increase in the number of pores and the stripping of starch surface layers were observed after defatting by scanning electron microscopy. X-ray diffraction spectrum ...
Márquez Lorenzo - - 2013
The gastric acid secretion of juvenile Sparus aurata was characterized in Ussing chambers; secretion rates were determined by a pH-stat method at pH5.50 and bioelectrical parameters were measured in current-clamped tissues. The basal secretion equaled 535±87nmol·cm(-2)·h(-1). Serosal carbachol 100μM produced an increase (ΔJH+) of 725±133nmol·cm(-2)·h(-1) from basal secretion, this effect ...
Tavano Lorena - - 2013
Recently niosomes have been used as nutraceutical vehicles of functional components, useful in the prevention of many diseases caused by oxidative stress, with the aim to control their delivery into the body and to increase the nutritional quality of food dairy products with which these products can be enriched. We ...
Uygur R - - 2013
The aim of this study was to examine the protective effects of fish omega-3 (n-3) fatty acids on acute doxorubicin (DOX)-induced testicular apoptosis and oxidative damage. 24 male rats were divided into three groups: control, DOX-treated and DOX+fish n-3 fatty acids. Fish n-3 fatty acids (400 mg kg(-1) ) were given ...
Menichini Francesco - - 2013
Abstract Cardiospermum halicacabum is widely used in traditional medicine. Previous studies have focused on the aerial parts, while the seeds have been poorly investigated. This work aimed to analyse the chemical composition of extracts from aerial parts and seeds obtained using Naviglio and Soxhlet (PN, PS, and SN, SS, respectively), ...
Le Masurier Marisa - - 2013
Depletion of the catecholamine precursor tyrosine using tyrosine-free amino acid mixtures is an important tool in neuropsychological studies, and often considered dopamine selective on the basis of neuropharmacological studies. However, little is known of the effects of tyrosine depletion when catecholamine neurons are activated physiologically. Here we investigated the effect ...
Lozano Aquiles - - 2013
A deficit in adiponectin plays an important causal role in insulin resistance and metabolic syndrome. We hypothesized that as seen during the fasting state, the intake of a walnut-enriched meal increased postprandial adiponectin. Twenty-one healthy white men followed a 4-week baseline diet and then consumed 3 fat-loaded meals that included ...
Kim Sol - - 2014
Glycol chitosan (GC) grafted with 2,3-dimethylmaleic acid (DMA) and fullerene (C60) conjugates (GC-g-DMA-g-C60) were developed for use in a photosensitizer prodrug. GC-g-DMA-g-C60 was prepared via the simple two-step chemical grafting reactions of (i) DMA to free amine groups of GC and (ii) hydroxyl groups of GC-g-DMA to ππ carbon bonds ...
Wang Hong-Wei - - 2013
A novel laccase (LACB3) from the endophytic fungus, Phomopsis liquidambari, was cloned and its potential to promote peanut growth was evaluated. The full-length cDNA is 1,731 bp, encoding a mature protein of 556 amino acids with a molecular mass of 60.1 kDa. Using 2,2'-azino-bis(3-ethylbenzthiazoline-6-sulfonate), LACB3 exhibited a K m and k cat ...
Jia Yong - - 2013
Fungi had become the main resource of polyunsaturated fatty acids, especially linoleic acid. The research studied the effects and mechanism of selenium on polyunsaturated fatty acids of Diasporangium jonesianum. The results showed that selenium could significantly increase the yields of linoleic acid. In contrast, the growth and γ-linolenic acid yield ...
Shen Qian - - 2013
Abstract Our findings show that temperature plays a significant role in the induction of acid-stress adaptation in Listeria monocytogenes, and two distinct patterns were observed: (1) Presence of sublethal acid at 37°C or 22°C significantly induced acid-stress adaptation; and (2) Presence of sublethal acid at 4°C did not induce any ...
Tongpim Saowanit - - 2013
By applying non-sterile open fermentation of food waste, various thermotolerant l-lactic acid-producing bacteria were isolated and identified. The predominant bacterial isolates showing higher accumulation of l-lactic acid belong to 3 groups of Bacillus coagulans, according to their 16S rRNA gene sequence similarities. B. coagulans strains M21 and M36 produced high amounts ...
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