Search Results
Results 1 - 50 of 3555
1 2 3 4 5 6 7 8 9 10 >
Tee Lee Hong LH Chemical Engineering Discipline, School of Engineering, Monash University, Jalan Lagoon Selatan, 47500 Bandar Sunway, Selangor, - - 2014
Dacryodes species are evergreen, perennial trees with fleshy fruits and belong to the family Buseraseae. Many Dacryodes species are underutilized but are widely applied in traditional folk medicine to treat malaria, fever and skin diseases. The nutritional compositions, phytochemicals and biological activities of Dacryodes edulis, Dacryodes rostrata, Dacryodes buettneri, Dacryodes ...
Oliveira Raquel R Centro de Química, Universidade do Minho, Campus de Gualtar, 4710-057 Braga, - - 2014
A method is proposed and tested concerning the characterization of antioxidants by means of their reaction with electrogenerated HO radicals in galvanostatic assays with simultaneous O2 evolution, using a Pt anode fairly oxidized. The consumption of a set of species with antioxidant activity, ascorbic acid (AA), caffeic acid (CA), gallic ...
Gökalp Hilal H Department of Dermatology, Malatya Government Hospital, Malatya, - - 2014
Oral isotretinoin treatment might influence the levels of vitamin B12 and folic acid. The aim of this study is to compare vitamin B12 and folic acid levels in patients with moderate and severe acne vulgaris with those of the healthy control group and to investigate the effect of isotretinoin treatment ...
Jang Yoonsun Y World Class University (WCU) Program of Chemical Convergence for Energy & Environment (C2E2) School of Chemical and Biological Engineering, College of Engineering, Seoul National University (SNU), Seoul, Korea. - - 2014
The folic acid conjugated hollow nanosphere is used to encapsulate protoporphyrin IX and is utilized for photodynamic therapy. This system represents a 3.33 times higher photodynamic efficiency than previous protoporphyrin IX-based systems. The result proposes a new opportunity for effective photodynamic therapy of folate receptor positive tumor cells.
Park Dongjin D Molecular Imaging & Therapy Branch, National Cancer Center, 323 Ilsan-ro, Goyang-si, Gyeonggi-do 410-769, Korea. - - 2014
Doxorubicin-loaded hyaluronic acid-polypyrrole nanoparticles were developed for pH-responsive activatable fluorescence imaging and therapy of proliferating macrophages.
Huerta-Angeles Gloria G Contipro Pharma a.s., Dolni Dobrouč 401, 561 02 Dolni Dobrouč, Czech Republic. Electronic address: - - 2014
The present work describes a novel and efficient method of synthesis of amphiphilic hyaluronan (HA) by esterification with alkyl fatty acids. These derivatives were synthesized under mild aqueous and well controlled conditions using mixed aliphatic aromatic anhydrides. These anhydrides characterized by the general formula RCOOCOC6H2Cl3 can be easily prepared by ...
Liu Yefei Y CAS Key Laboratory of Bio-based Materials, Qingdao Institute of Bioenergy and Bioprocess Technology, Chinese Academy of Sciences, 189 Songling Road, Qingdao 266101, China; University of Chinese Academy of Sciences, Beijing 100049, - - 2014
In this work, a sustainable and green process to prepare nanocrystalline cellulose (NCC) from bleached hardwood pulp was demonstrated. Rod-like nanocrystalline cellulose with the size of 15-40nm in width and hundreds of nanometers in length was obtained through H3PW12O40 (HPW)-catalyzed hydrolysis of bleached pulp fibers under the mild reaction conditions. ...
Hattori Yoshihide Y Research Center of Boron Neutron Capture Therapy, Research Organization for the 21st Century, Osaka Prefecture University, 1-1 Gakuen-cho, Nakaku, Sakai, Japan, - - 2014
Boron-neutron capture therapy (BNCT) is an attractive technique for cancer treatment. As such, α, α-cycloalkyl amino acids containing thiododecaborate ([B12H11](2-)-S-) units were designed and synthesized as novel boron delivery agents for BNCT. In the present study, new thiododecaborate α, α-cycloalkyl amino acids were synthesized, and biological evaluation of the boron ...
Gholami Zahra - - 2014
Conjugated linoleic acid (CLA) has attracted considerable attention in health due to its important physiological properties proved in several in vivo experiments. Many bacteria, especially some probiotics, are able to produce CLA from the linoleic acid (LA) present in milk. In this review, CLA production by microorganisms is described. Then ...
Turan Başak B Graduate School of Natural and Applied Sciences, Biochemistry Department, Ege University, 35100, Bornova, Izmir, - - 2014
Amino acids are constituents of proteins and enzymes which take part almost in all metabolic reactions. Glutamic acid, with an ability to form a negatively charged side chain, plays a major role in intra and intermolecular interactions of proteins, peptides, and enzymes. An exhaustive conformational analysis has been performed for ...
Chumsae Chris - - 2014
Recombinant therapeutic monoclonal antibodies exhibit a high degree of heterogeneity that can arise from various post-translational modifications. The formulation for a protein product is to maintain a specific pH and to minimize further modifications. Generally Recognized as Safe (GRAS), citric acid is commonly used for formulation to maintain a pH ...
Neuber Corinna - - 2014
Sphingosine 1-phosphate (S1P), a bioactive lipid involved in various physiological processes, can be irreversibly degraded by the membrane-bound S1P lyase (S1PL) yielding (2E)-hexadecenal and phosphoethanolamine. It is discussed, that (2E)-hexadecenal is further oxidized to (2E)-hexadecenoic acid by the long-chain fatty aldehyde dehydrogenase ALDH3A2 (also known as FALDH) prior to activation ...
Milligan G G Molecular Pharmacology Group, Institute of Molecular, Cell and Systems Biology, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow G12 8QQ, Scotland, - - 2014
The G protein-coupled receptors FFA1 (previously designated GPR40) and FFA4 (previously GPR120) are both activated by saturated and unsaturated longer-chain free fatty acids. With expression patterns and functions anticipated to directly or indirectly promote insulin secretion, provide homeostatic control of blood glucose and improve tissue insulin sensitivity, both receptors are ...
Li Yongguo Y Molecular Nutritional Medicine, Else Kröner Fresenius Center for Nutritional Medicine, Technische Universität München, Freising, - - 2014
Thermogenesis in brown adipocytes, conferred by mitochondrial uncoupling protein 1 (UCP1), is receiving great attention because metabolically active brown adipose tissue may protect humans from metabolic diseases. In particular, the thermogenic function of brown-like adipocytes in white adipose tissue, known as brite (or beige) adipocytes, is currently of prime interest. ...
Xie Guoxiang - - 2014
Recent studies have identified that several amino acids, in particular, branched-chain amino acids (BCAAs), increased significantly in obese compared with lean individuals. Additionally, these metabolites were strongly associated with future diabetes, rendering them prognostic markers suitable for obese populations. Here we report a metabonomic study that reveals new findings on ...
Kashiwagi Yasuyo Y Department of Pediatrics, Tokyo Medical University, - - 2014
Rotavirus is the most common cause of severe gastroenteritis in young children; however, its pathogenesis and immunity are not completely understood. Even less well recognized is rotavirus-induced central nervous system (CNS) involvement, which has been associated with seizure, encephalopathy and death, among others. To elucidate the host response to rotavirus ...
Chidambaram Archana A Department of Materials Science and Engineering, University of Florida, 210A Rhines Hall, P.O. Box 116400, Gainesville, FL, 32611-6400, USA, - - 2014
Randall's plaque (RP) deposits seem to be consistent among the most common type of kidney stone formers, idiopathic calcium oxalate stone formers. This group forms calcium oxalate renal stones without any systemic symptoms, which contributes to the difficulty of understanding and treating this painful and recurring disease. Thus, the development ...
Wu Jason Hy JH The George Institute for Global Health, Sydney Medical School, The University of Sydney, Sydney, New South Wales, Australia - - 2014
-While omega-6 polyunsaturated fatty acids(n-6 PUFA) have been recommended to reduce CHD, controversy remains about benefits vs. harms, including concerns over theorized pro-inflammatory effects of n-6 PUFA. We investigated associations of circulating n-6 PUFA including linoleic acid(LA, the major dietary PUFA), γ-linolenic acid(GLA), dihomo-γ-linolenic acid(DGLA), and arachidonic acid(AA),with total and ...
Li Jun-Long JL Organisch-Chemisches Institut, NRW Graduate School of Chemistry, Westfälische Wilhelms-Universität Münster, Corrensstrasse 40, 48149 Münster (Germany) - - 2014
A sterically hindered homoenolate has been generated by the NHC-catalyzed conjugate umpolung of β,β-disubstituted enals and successfully employed in a facile stereoselective annulation with isatins. The strategy provides efficient access to spirocyclic oxindoles bearing two highly congested contiguous quaternary carbon centers. The use of a Brønsted acid cocatalyst was found ...
Eggert Thorsten T evocatal GmbH, Alfred-Nobel-Str. 10, 40789 Monheim am Rhein, Germany. Electronic address: - - 2014
Ursodeoxycholic acid, a secondary bile acid, is used as a drug for the treatment of various liver diseases, the optimal dose comprises the range of 8 to 10mg/kg/day. For industrial syntheses, the structural complexity of this bile acid requires the use of an appropriate starting material as well as the ...
Vanegas Julie P JP Instituto de Ciencia Molecular (ICmol), Univ. Valencia, Catedrático José Beltrán 2, 46980, Paterna, Valencia, Spain. jupauva@alumni.uv.es - - 2014
A ratiometric, specific probe of formic acid has been developed. It is based on intermolecular nucleobase-pairing of inosine-capped plasmonic nanoparticles to form nucleoside channels, which are destabilised by the analyte.
Barlow T M A TM Research Group of Organic Chemistry, Departments of Chemistry and Bioengineering Sciences, Vrije Universiteit Brussel, Pleinlaan 2, B-1050 Brussels, Belgium. mouhamad.jida@vub.ac.be - - 2014
Herein we describe a catalyst-free procedure employing an Ugi-4CR between a β-azido-α-amino acid, propargylamine, an isocyanide and an aldehyde, followed by a thermal azide-alkyne Huisgen cycloaddition to generate a 16-member library of amino-triazoloazepinone-bearing di- and tripeptides with up to four points of diversification and high atom economy.
Brew B K BK Woolcock Institute of Medical Research, University of Sydney, Sydney, NSW, - - 2014
Background/objectives:Consumption of oily fish more than once per week has been shown to improve cognitive outcomes in children. However, it is unknown whether similar benefits can be achieved by long-term omega-3 fatty acid supplementation. The objective was to investigate the effect of omega-3 fatty acid supplementation during the first 5 ...
Falck John R - - 2014
The cytochrome P450 eicosanoid 14,15-epoxyeicosa-5,8,11-trienoic acid (14,15-EET) is a powerful endogenous autacoid that has been ascribed an impressive array of physiologic functions including regulation of blood pressure. Since 14,15-EET is chemically and metabolically labile, structurally related surrogates containing epoxide bioisosteres were introduced and have become useful in vitro pharmacologic tools, ...
Chisaguano Aida Maribel AM 1] Department of Nutrition and Food Science, Faculty of Pharmacy, University of Barcelona, Barcelona, Spain. [2] CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), Instituto de Salud Carlos III (ISCIII), Spanish Government, Madrid, - - 2014
BACKGROUND:Few studies have explored whether fetal exposure to trans fatty acids (TFAs) influences the inception of atopic diseases. The aim of this study was to investigate the relationship between the concentration of specific TFAs (elaidic, vaccenic and rumenic acid) in maternal plasma and the risk of developing atopic manifestations in ...
Passioura Toby T Department of Chemistry, Graduate School of Science, The University of Tokyo, 7-3-1 Bunkyo-ku, Tokyo 113-0033, - - 2014
The site-specific introduction of non-canonical amino acids into polypeptides through genetic code reprogramming has become a powerful tool for biochemical studies and bioorganic synthesis. Although a variety of such techniques have been developed, all are based on the 'mis-acylation' of tRNA molecules with non-canonical amino acids. Multiple strategies have been ...
Zhang Zhicai Z Institute of Agro-production Processing Engineering, Jiangsu University, Xuefu Road 301, Zhenjiang, 212013, People's Republic of China, - - 2014
Fresh biomass of Aspergillus oryzae (A. oryzae) CGMCC5992 can effectively remove gallic acid from aqueous solution. To improve the removal rate of gallic acid, this study first identified the important factors affecting the removal rate of gallic acid with univariate analysis, and then used four-factor and three-level Box-Behnken design (BBD) ...
Santini Antonello A Department of Pharmacy, University of Napoli Federico II, Via D. Montesano 49, 80131, Napoli, Italy, - - 2014
The secondary metabolite profiles of microfungi of the genus Penicillium isolated from samples of grape berries collected in two different phases during two vegetative seasons in Slovakia is described to assess the taxonomy. Three Slovak vine regions have been selected for this study, based on their climatic differences and national ...
Mandal Pijus K - - 2014
We report a very mild synthesis of N-protected alpha-methyl amines from corresponding amino acids. Carboxyl groups of amino acids are reduced to iodomethyl groups via hydroxymethyl intermediates. Reductive de-iodination to methyl groups is achieved by hydrogenation or catalytic transfer hydrogenation under alkaline conditions. Basic hydro-dehalogenation is selective for the iodomethyl ...
Deshpande Sagar - - 2014
Abstract Acyl migration in chlorogenic acids describes the process of migration of cinnamoyl moieties from one quinic acid alcohol group to another thus interconverting chlorogenic acid regioisomers. It therefore constitutes a special case of a transesterification reaction. Acyl migration constitutes an important reaction pathway in both coffee roasting and brewing ...
d'Ippolito Giuliana G Istituto di Chimica Biomolecolare, Consiglio Nazionale delle Ricerche, Via Campi Flegrei 34, 80078 Pozzuoli-Napoli - - 2014
The heterotrophic bacterium Thermotoga neapolitana produces hydrogen by fermentation of sugars. Under capnophilic (carbon dioxide requiring) conditions, the process is preferentially associated with the production of lactic acid, which, as shown herein, is synthesized by reductive carboxylation of acetyl coenzyme A. The enzymatic coupling is dependent on the carbon dioxide stimulated ...
Fasani Rick A RA Department of Biomedical Engineering and Microbiology Graduate Group, University of California, Davis, One Shields Avenue, Davis, CA 95616 - - 2014
Overcoming the stress of starvation is one of an organism's most challenging phenotypic responses. Those organisms that frequently survive the challenge, by virtue of their fitness, will have evolved genomes that are shaped by their specific environments. Understanding this genotype-environment-phenotype relationship at a deep level will require quantitative predictive models ...
Cladis Dennis P DP Department of Nutrition Science, Purdue University, Stone Hall, 700 W. State St., West Lafayette, IN, 47907-2059, - - 2014
Fillets of 76 finfish species (293 composites of three fish) were obtained from commercial seafood vendors in six regions of the United States (i.e., Great Lakes, Mid-Atlantic, New England, Northwest, Southeast, and Southwest). Full fatty acid profiles were determined for each species and are presented here. Eicosapentaenoic acid (EPA) and ...
Jansen Mickel LA ML DSM Biotechnology Center, Alexander Fleminglaan 1, 2613 AX Delft, The Netherlands. Electronic address: - - 2014
Fermentative production of succinic acid (SA) from renewable carbohydrate feed-stocks can have the economic and sustainability potential to replace petroleum-based production in the future, not only for existing markets, but also new larger volume markets. To accomplish this, extensive efforts have been undertaken in the field of strain construction and ...
Li Kaixin K Chemical and Biomedical Engineering, School of Chemical and Biomedical Engineering, Nanyang Technological University, Singapore 637459 (Singapore), - - 2014
Currently, levulinic acid (LA) and formic acid (FA) are considered as important carbohydrates for the production of value-added chemicals. Their direct production from biomass will open up a new opportunity for the transformation of biomass resource to valuable chemicals. In this study, one-pot transformation of cellobiose into LA and FA ...
Ye Chunhong C School of Light Industry Science and Engineering, Nanjing Forestry University, Nanjing, Jiangsu, 210037, PR China; School of Materials Science and Engineering, Georgia Institute of Technology, Atlanta, Georgia, 30332, - - 2014
Robust and stable microcapsules are assembled from poly-amino acid-modified silk fibroin reinforced with graphene oxide flakes using layer-by-layer (LbL) assembly, based on biocompatible natural protein and carbon nanosheets. The composite microcapsules are extremely stable in acidic (pH 2.0) and basic (pH 11.5) conditions, accompanied with pH-triggered permeability, which facilitates the ...
Valenzuela-Reyes Edgardo E División de Ciencias Ambientales, IPICyT, Instituto Potosino de Investigación Científica y Tecnológica, Camino a la Presa San José 2055, Lomas 4ta. Sección, C. P. 78216, San Luis Potosí, - - 2014
In this work, several conditions of pH and inlet load (IL) were applied to a scale laboratory biofilter treating n-hexane vapors during 143 days. During the first 79 days of operation (period 1, P1), the system was fed with neutral pH mineral medium (MM) and the IL was progressively decreased from 177 ...
Cespedes E E Departments of Nutrition and Epidemiology, Harvard School of Public Health, Boston, MA, - - 2014
Background:Evidence regarding the relationship of n-3 fatty acids (FA) to type 2 diabetes and metabolic syndrome components (MetS) is inconsistent.Objective:To examine associations of adipose tissue n-3 FA with MetS.Design:We studied 1611 participants without prior history of diabetes or heart disease who were participants in a population-based case-control study of diet ...
Montoya Guillermo - - 2014
Sugarcane industry worldwide have seen how biomass production in sugar mills would be converted in a readily source of molecules besides sugar. Properly managed, by-products would be transformed in a sustainable source of renewable and environmentally friendly chemical products. As a principal and more abundant organic acid in sugarcane juice, ...
Mori Takamichi T Graduate School of Engineering, Nagasaki University, 1-14 Bunkyo machi, Nagasaki 852-8521 (Japan) - - 2014
A nickel catalyst promotes the multicomponent coupling reaction of diketene, an alkyne, and Me2 Zn to provide 3-methylene-4-hexenoic acids in excellent yields. Under similar conditions, the combination of the nickel catalyst and Et2 Al(OEt) promotes a cycloaddition reaction involving dimerization of an alkyne to furnish phenylacetic acids. In the presence ...
Gong Yangmin Y Key Laboratory of Biology and Genetic Improvement of Oil Crops, Ministry of Agriculture, Oil Crops Research Institute of Chinese Academy of Agricultural Sciences, No. 2 Xudong Second Road, Wuhan 430062, PR China. Electronic address: - - 2014
Omega-3 long-chain polyunsaturated fatty acids (LC-PUFAs) have received growing attention due to their significant roles in human health. Currently the main source of these nutritionally and medically important fatty acids is marine fish, which has not met ever-increasing global demand. Microorganisms are an important alternative source also being explored. Although ...
Davidson Michael H MH Department of Medicine, The University of Chicago, 5841 S. Maryland Avenue, MC 6080, Chicago, IL 60637, - - 2014
The incidence of hypertriglyceridemia has grown alongside that of obesity. Statin therapy has been widely recommended for the treatment of dyslipidemias. Omega-3 (OM3) fatty acid concentrates are commonly prescribed concurrently with statins in patients with persistent hypertriglyceridemia for additional lowering of triglyceride and non-HDL cholesterol. The bioavailability of currently available ...
Georgiopoulos P P School of Applied Mathematical and Physical Sciences, Department of Mechanics, National Technical University of Athens, Athens, - - 2014
In this work a series of polylactic acid/SiO2 nanocomposites have been prepared by a melt mixing procedure. The dispersion quality was examined by scanning electron microscopy. To study the degradation behavior of the polylactic acid/nanocomposites prepared, the samples were immersed in a buffer solution at a temperature of 37℃ with ...
Sasaki Makoto M Graduate School of Life Sciences, Tohoku University, Katahira, Aoba-ku, Sendai 980-8577, Japan. - - 2014
More than thirty years after the discovery of polycyclic ether marine natural products, they continue to receive intense attention from the chemical, biological, and pharmacological communities because of their potent biological activities and highly complex molecular architectures. Gambieric acids are intriguing polycyclic ethers that exhibit potent antifungal activity with minimal ...
Myung Jaewook J Department of Civil and Environmental Engineering, Stanford University, Stanford, CA 94305-4020, - - 2014
An abiotic-biotic strategy for recycling of polyhydroxyalkanoates (PHAs) is evaluated. Base-catalyzed PHA depolymerization yields hydroxyacids, such as 3-hydroxybutyrate (3HB), and alkenoates, such as crotonate; catalytic thermal depolymerization yields alkenoates. Cyclic pulse addition of 3HB to triplicate bioreactors selected for an enrichment of Comamonas, Brachymonas and Acinetobacter. After each pulse, poly(3-hydroxybutyrate) ...
Arafiles Kim Hazel V KH Graduate School of Advanced Sciences of Matter, Hiroshima University, Higashi-Hiroshima, 739-8530, - - 2014
Thraustochytrid production of polyunsaturated fatty acids and xanthophylls have been generally sourced from crop-derived substrates, making the exploration of alternative feedstocks attractive since they promise increased sustainability and lower production costs. In this study, a distinct two-stage fermentation system was conceptualized for the first time, using the brown seaweed sugar ...
Castro Kamila - - 2014
Autism spectrum disorders (ASD) consist in a range of neurodevelopmental conditions that share common features with autism, such as impairments in communication and social interaction, repetitive behaviors, stereotypies, and a limited repertoire of interests and activities. Some studies have reported that folic acid supplementation could be associated with a higher ...
Tabata Atsushi A Department of Biological Science and Technology, Life System, Institute of Technology and Science, The University of Tokushima Graduate School, Tokushima, - - 2014
This study aimed to determine the preferred conditions for the transpeptidase reaction of sortase A from Staphylococcus aureus, for the purpose of creating functional liposomes useful for a drug-delivery system (DDS). His-tagged recombinant sortase A with 59 amino acids deleted from the N-terminus (His-ΔN59SrtA) was prepared using an Escherichia coli ...
Dhamole Pradip B PB Department of Chemical Engineering, Birla Institute of Technology and Science, Pilani Hyderabad Campus, R.R. District, Hyderabad, 500078, Telangana, India, - - 2014
Ferulic acid (FA) and p-coumaric acid (pCA) are high-value products that can be obtained by alkaline hydrolysis of lignocellulose. Present work explores the potential of surfactant-based cloud-point extraction (CPE) for FA and pCA extraction from corn cob hydrolysate. More than 90 % (w/w) extraction of both FA and pCA was achieved ...
Rafiqul I S M IS Faculty of Chemical and Natural Resources Engineering, Universiti Malaysia Pahang, 26300 Kuantan, Pahang, - - 2014
Xylitol production by bioconversion of xylose can be economically interesting if the raw material can be recovered from a cheap lignocellulosic biomass (LCB). Meranti wood sawdust (MWS) is a renewable and low-cost LCB that can be used as a promising and economic source of xylose, a starting raw material for ...
1 2 3 4 5 6 7 8 9 10 >