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Malan André A Institute for Cellular and Integrative Neurosciences, CNRS and University of Strasbourg, 5 Rue Blaise Pascal, 67084 Strasbourg Cedex, - - 2014
The conquest of land has endowed air-breathers with the capability to utilize ventilation not only to acquire oxygen but also to control blood and intracellular acid-base state. Hypercapnic acidosis (resulting from ventilatory control and/or behavioral choice), thus, has become a universal component of hypometabolic states in air-breathers, with inhibitory and/or ...
He Yanqing Y State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, 130 Meilong Road, Shanghai 200237, - - 2014
Impregnation of lignocellulose materials with dilute acid solution is a routine operation in conventional dilute acid pretreatment. The dry dilute acid pretreatment (DDAP) at high solids content up to 70% is naturally considered to require longer impregnation time. In this study, a co-currently feeding operation of corn stover and dilute ...
Wang Yechun Y Donald Danforth Plant Science Center, 975 North Warson Road, Saint Louis, MO, 63132, - - 2014
Malonyl-CoA is the essential building block of natural products such as fatty acids, polyketides, and flavonoids. Engineering the biosynthesis of fatty acids is important for biofuel production while that of polyketides provides precursors of medicines and nutritional supplements. However, microorganisms maintain a small amount of cellular malonyl-CoA, which could limit ...
Hibi Makoto M Industrial Microbiology, Graduate School of Agriculture, Kyoto University, Kitashirakawa-oiwakecho, Sakyo-ku, Kyoto, 606-8502, - - 2014
The asymmetric hydroxylation of inactive carbon atoms is still an important reaction in the industrial synthesis of valuable chiral compounds such as pharmaceuticals and fine chemicals. Applications of monooxygenation enzymes, like cytochrome P450 monooxygenases, flavin-containing monooxygenases, and Fe(II)/α-ketoglutarate-dependent dioxygenases (Fe/αKG-DOs), are strongly desired as hydroxylation biocatalysts because they have great ...
Longhi Catia C Department of Public Health and Infectious Diseases, Sapienza University, P.le A. Moro 5, 00185 Rome, Italy. Electronic address: - - 2014
It has been suggested that the rarity of human listeriosis due to Listeria ivanovii reflects not only host tropism factors but also the rare occurrence of this species in the environment, compared with Listeria monocytogenes. In the present study we evaluate the effects on the reference strain L. ivanovii ATCC 19119 ...
Finkbeiner Peter P Institut für Organische Chemie, Eberhard Karls Universität Tübingen , Auf der Morgenstelle 18, 72076 Tübingen, - - 2014
An efficient electrophilic alkynylation of azlactones (oxazol-5(4H)-ones) is developed using alkynyl(phenyl)iodonium salts as the electrophilic alkyne source. After remarkably short reaction times, the desired alkyne functionalized azlactones are obtained in 60-97% yield and can be transformed easily into a variety of quaternary α-amino acid derivatives.
Kotouńćová Hana H Department of Organic Chemistry, Institute of Chemical Technology, Prague, Technická 5, 16628 Prague 6, Czech Republic. - - 2014
Flavin-catalysed oxidative hydroxylation of substituted arylboronic acids by molecular oxygen with the assistance of hydrazine or ascorbic acid resulted in phenols in high yields. This mild organocatalytic protocol is compatible with a variety of functional groups and it is alternatively usable for transformation of alkylboronic acids to alcohols. Reaction takes ...
Schäfer Gabriel G Laboratorium für Organische Chemie, Department of Chemistry and Applied Biosciences, ETH Zürich , Vladimir Prelog Weg 1-5, 8093 Zürich, - - 2014
Sterically hindered N-acyl, gem-disubstituted amino acids are easily prepared via the addition of organometallic reagents to N-carboxyanhydrides (NCA). The process tolerates a wide variety of functional groups and allows the synthesis of amide products not readily accessible by traditional acylation chemistry. The existence of an isocyanate intermediate was established by ...
Zhou Pan-Pan - - 2014
Nicotinic acid is a well-known pharmaceutical in vitamin B group that has attracted great interest in the past decades due to its significant importance in the treatment of the human diseases like pellagra. Also, nicotinic acid derivatives have been devoted to much attention due to their different pharmaceutical effects in ...
Vilcocq Léa L Centro de Química da Madeira, Universidade da Madeira, Campus da Penteada, 9020-105 Funchal - - 2014
Mild fractionation/pretreatment processes are becoming the most preferred choices for biomass processing within the biorefinery framework. To further explore their advantages, new developments are needed, especially to increase the extent of the hydrolysis of poly- and oligosaccharides. A possible way forward is the use of solid acid catalysts that may ...
Subba Reddy Basireddy Venkata - - 2014
An unprecedented oxa- vs thia- selectivity has been observed in Prins cyclization of 6-mercaptohex-3-en-1-ol with aldehydes. In the presence of a stoichiometric amount of strong Lewis or Bronsted acids,the reaction provides the hexahydro-2H-thieno[3,2-c]pyran skeleton predominantly via oxonium-Prins cyclization. In contrast, a catalytic amount of weak Lewis or Bronsted acids provides ...
Ma Xiao X School of Chemistry, Northeast Normal University, Changchun, 130024 (P. R. China), Fax: - - 2014
Carbon nanotubes (CNTs) have been widely employed as electrode materials in diverse branches of electrochemistry, which are claimed to display dramatically improved electrochemical behaviour compared to the conventional carbon materials. But a series of recent publications have demonstrated that the electrocatalysis of CNTs might be due to the presence of ...
Gualandi Andrea A Dipartimento di Chimica "G. Ciamician", ALMA MATER STUDIORUM, Università di Bologna, Via Selmi 2, 44126, Bologna (Italy), Fax: - - 2014
In recent years there has been an accelerated rate of development in the field of organocatalysis, with asymmetric organocatalysis now reaching full maturity. The invention of new organocatalytic reactions and the exploration of new concepts now appear in tandem with the application of organocatalytic techniques in the synthesis of natural ...
Zhang Di D Department of Landscape Science and Engineering, School of Agriculture and Biology, Shanghai Jiao Tong University, Shanghai 200240, - - 2014
The transition from vegetative to reproductive growth represents a major phase change in angiosperms. Hormones play important roles in this process. In this study, gibberellic acid (GA), cytokinins (CKs), indoleacetic acid (IAA), and abscisic acid (ABA) were analyzed during the flowering in Agapanthus praecox ssp. orientalis. Eleven types of endogenous ...
Yang Senpei S CAU & ACC Joint-Laboratory of Space Food, College of Food Science and Nutritional Engineering, Beijing Key Laboratory of Functional Food from Plant Resources, China Agricultural University, Beijing 100083, - - 2014
Under physiological conditions, exogenous chelators such as polyphenols might interact with non-protein bound ferric complexes, such as Fe(III)-citrate. Additionally, Fe(III) and citrate are widely distributed in various fruits and vegetables which are also rich in phenolic acids. In this study, we focus on the interaction between phenolic acids (gallic acid, ...
Xu Yu Y School of Chemistry and Chemical Engineering, Shandong University, Jinan 250100, PR China; Taishan College, Shandong University, Jinan 250100, PR - - 2014
A novel turn-off fluorescent probe based on coumarin and imidazole moiety for extremely acidic conditions was designed and developed. The probe with pKa=2.1 is able to respond to very low pH value (below 3.5) with high sensitivity relying on fluorescence quenching at 460nm in fluorescence spectra or the ratios of ...
Sullivan Michael L ML US Dairy Forage Research Center, US Department of Agriculture, Agricultural Research Service, 1925 Linden Drive, Madison, WI, 53705, USA, - - 2014
Many plants accumulate hydroxycinnamoyl esters to protect against abiotic and biotic stresses. Caffeoyl esters in particular can be substrates for endogenous polyphenol oxidases (PPOs). Recently, we showed that perennial peanut (Arachis glabrata Benth.) leaves contain PPO and identified one PPO substrate, caftaric acid (trans-caffeoyl-tartaric acid). Additional compounds were believed to ...
Fenech Goël G Paris Descartes University, Faculty of Medicine, AP-HP, Diagnosis and Therapeutic Center, Hôtel-Dieu University Hospital, place du Parvis-Notre-Dame, Paris, - - 2014
Hyperuricaemia is commonly found in subjects with cardiovascular disease, but its role as risk factor is very controversial. Although several studies reported serum uric acid as a marker of an underlying pathophysiological process, other studies hypothesis a potential causal link between serum uric acid and cardiovascular diseases. Some studies suggest ...
Guschina Irina A IA School of Biosciences, Cardiff University, Cardiff CF10 3AX, - - 2014
Although there is much knowledge of the enzymology (and genes coding their proteins) of lipid biosynthesis in higher plants, relatively little attention has been paid to regulation. We have demonstrated the important role for cholinephosphate cytidylyltransferase in the biosynthesis of the major extra-plastidic membrane lipid, phosphatidylcholine. We followed this work ...
Berry Susan A SA University of Minnesota, Minneapolis, MN, USA. Electronic address: - - 2014
To evaluate glycerol phenylbutyrate (GPB) in the treatment of pediatric patients with urea cycle disorders (UCDs). UCD patients (n=26) ages 2months through 17years were treated with GPB and sodium phenylbutyrate (NaPBA) in two short-term, open-label crossover studies, which compared 24-hour ammonia exposure (AUC0-24) and glutamine levels during equivalent steady-state dosing ...
Pinto Isabel S S IS 1REQUIMTE, Departamento de Engenharia Química, Faculdade de Engenharia, Universidade do Porto, Rua Dr. Roberto Frias, 4200-465, Porto, - - 2014
Aminopolycarboxylates, like ethylenediaminetetraacetic acid (EDTA) and diethylenetriaminepentaacetic acid (DTPA), are chelating agents widely used in several industrial, agricultural, and domestic applications. However, the fact that they are not biodegradable leads to the presence of considerable amounts in aquatic systems, with serious environmental consequences. The replacement of these compounds by biodegradable ...
Lemercier Bérénice C BC Department of Chemistry, North Carolina State University , Raleigh, North Carolina 27695, United - - 2014
An improved and expanded preparation of thiohydroxamic acids is reported along with a one-pot conversion of these compounds to novel thiohydroximic acid derivatives. A variety of aryl, heteroaryl, and alkyl substituents are well tolerated to provide a rapid approach to alkene-functionalized thiohydroximic acids that serve as potentially useful building blocks ...
Sydney Eduardo Bittencourt EB Bioprocess Engineering and Biotechnology Department, Federal University of Parana, Centro Politécnico, Usina Piloto B, CEP 81531-990 Curitiba, Paraná, Brazil; Clermont Université, Université Blaise Pascal, Labex IMobS3, Institut Pascal, Polytech Clermont-Ferrand, 24 avenue des Landais, BP 20206, 63174 Aubière Cedex, - - 2014
This work evaluates the potential of vinasse (a waste obtained at the bottom of sugarcane ethanol distillation columns) as nutrient source for biohydrogen and volatile fatty acids production by means of anaerobic consortia. Two different media were proposed, using sugarcane juice or molasses as carbon source. The consortium LPBAH1 was ...
Cronan John E JE Departments of Microbiology and Biochemistry, University of Illinois, Urbana, Illinois - - 2014
The Firmicute bacteria readily incorporate exogenous fatty acids into their phospholipids. In some (but not all) family members incorporation of the fatty acids present in human serum precludes the use of fatty acid synthesis inhibitors to treat infections. However, the pathway(s) of exogenous fatty acid incorporation in these bacteria remained ...
Xu Xianghuai X Department of Respiratory Medicine, Tongji Hospital, Tongji University School of Medicine, Shanghai, - - 2014
Little is known about non-acid gastroesophageal reflux-induced chronic cough (GERC). The purpose of the study is to explore the clinical characteristics of non-acid GERC. Clinical symptoms, cough symptom score, capsaicin cough sensitivity, gastroesophageal reflux diagnostic questionnaire (GerdQ) score, findings of multichannel intraluminal impedance-pH monitoring (MII-pH) and response to pharmacological anti-reflux ...
Arean Carlos O CO Department of Chemistry, University of the Balearic Islands, 07122 Palma de Mallorca, Spain. - - 2014
Brønsted-acid zeolites are currently being used as catalysts in a wide range of technological processes, spanning from the petrochemical industry to biomass upgrade, methanol to olefin conversion and the production of fine chemicals. For most of the involved chemical processes, acid strength is a key factor determining catalytic performance, and ...
Wagner Anna M AM Department of Chemistry, University of Michigan , 930 North University Avenue, Ann Arbor, Michigan 48109, United - - 2014
The preparation of diaryl and alkyl aryl sulfides via acid-mediated coupling of thiols and thioethers with diaryliodonium salts is reported. The scope, limitations, and mechanism of the transformation are discussed.
Yu Haibo H School of Chemistry, University of Wollongong, Wollongong NSW 2552, Australia. - - 2014
Glycoside hydrolase families 33 and 34 catalyse the hydrolysis of terminal sialic acid residues from sialyl oligosaccharides and glycoconjugates with a net retention of the stereochemistry at the anomeric centre. It is generally believed that the conserved aspartic acid in the active site functions as a general acid to protonate ...
Peng Wei - - 2014
Triterpenoids were thought to be biologically ineffective for a very long time, but aggregating proof on their widely range pharmacological activities paired with dubious toxicity portrait has motivated regenerated attraction for human health and disease. In the current contribution, our central goal was to integrative dissect the biointeraction of two ...
Wulff-Pérez Miguel M Biocolloid and Fluid Physics Group, Department of Applied Physics, Faculty of Sciences, University of Granada, 18071 Granada, - - 2014
Oral drug delivery systems based on lipids are biodegraded in a process called lipolysis to release free fatty acids and monoglycerides. The rate of this lipolysis is usually measured by pH titration. Nevertheless, this technique has some limitations, such as not providing any information about the actual composition of the ...
Sherlock Huang Lin-Chiang LC Nuclear Science & Technology Development Center, National Tsing Hua University, Hsinchu 30013, Taiwan; Department of Chemistry, National Tsing Hua University, Hsinchu 30013, - - 2014
This work presents a novel approach for labeling hippuric acid with I-131 using microwaves. It utilizes copper(II) acetate as a catalyst of the labeling. The process involves the use of this catalytic copper(II) acetate at low dilutions that were nevertheless sufficient to produce labeled hippuric acid with high radiochemical purity ...
Kern Wolfram W Biologics Process Research and Development, Novartis Pharma, Postfach, 4002 Basel, - - 2014
Isomerization of aspartic acid residues is one of the major causes of chemical degradation during the shelf life of biological pharmaceuticals. Monoclonal antibody biopharmaceuticals are typically stored at mildly acidic pH conditions, which can lead to the isomerization reaction. The mechanism of this non-enzymatic chemical reaction has been studied in ...
Ulrich Andrea E AE Institute for Environmental Decisions (IED), Natural and Social Science Interface, ETH Zurich Universitässtrasse 22, 8092 Zurich, Switzerland; Institute for Agricultural Sciences, Plant Nutrition, ETH Zurich, Eschikon 33, 8315 Lindau, Switzerland. Electronic address: - - 2014
This study seeks to identify and specify the components that make up the prospects of U recovery from phosphate rock. A systems approach is taken. The assessment includes i) reviewing past recovery experience and lessons learned; ii) identifying factors that determine recovery; and iii) establishing a contemporary evaluation of U ...
Gibson Matthew I MI Laboratoire des Polymères, Ecole Polytechnique Fédérale de Lausanne, CH-1015 Lausanne, - - 2014
Epimerisation between ribofuranose and arabinofuranose sugars is crucial in several biosynthetic pathways, but is typically challenging to monitor. Here, we have screened for fluorescent boronic acids that can be used as molecular probes for the specific detection of ribofuranose over arabinofuranose sugars in solution. We show excellent specificity of the ...
Silvia Sandrone Silvana SS Biología Celular, Histología y Embriología, Facultad de Ciencias Médicas, INICSA (CONICET-Universidad Nacional de Córdoba), Córdoba, Argentina; Servicio de Patología, Hospital Rawson de Córdoba, Córdoba, - - 2014
Certain polyunsaturated fatty acids (PUFAs) called essential fatty acids (EFAs) cannot be biosynthesized by the body and hence, need to be obtained from diet. These PUFAs and their metabolites have multiple physiological functions that are altered in tumor cells due to a decreased expression of Δdelta-6-desaturase, which is an essential ...
Hao Guangfei G State Key Laboratory of Food Science and Technology, School of Food Science and Technology, Jiangnan University, Wuxi 214122, P.R. - - 2014
The generation of NADPH by malic enzyme (ME) was postulated to be a rate-limiting step during fatty acid synthesis in oleaginous fungi, primarily based on the results from research focusing on ME in Mucor circinelloides. This hypothesis is challenged by a recent study showing that leucine metabolism, rather than ME, ...
Wei Wei W The Key Laboratory of Life-Organic Analysis, Qufu Normal University, Qufu 273165, China. - - 2014
A novel Cu-catalyzed direct hydrosulfonylation of alkynes with arylsulfinic acids for the synthesis of (E)-vinyl sulfones has been realized under mild conditions with 100% atom efficiency. The present protocol provides an attractive approach to various vinyl sulfones in good to excellent yields, with the advantages of operation simplicity, atom economy, ...
Manrique-Arias Juan C JC Unidad PET, Facultad de Medicina, Universidad Nacional Autónoma de México, México, D.F., Mexico; Facultad de Ciencias, Universidad Autónoma del Estado de México, Toluca, Edo. México, - - 2014
Nickel targets for the cyclotron production of (64)Cu were prepared by electrodeposition on a gold backing from nickel chloride solutions using boric acid as buffer. Parameters studied were nickel chloride and boric acid concentration, temperature and current density. All plating conditions studied were successful obtaining efficiencies of approximately 90% in ...
Wang Cuiping C Key Laboratory for Functional Material, Educational Department of Liaoning Province, University of Science and Technology Liaoning, Anshan, 114051, P. R. China. - - 2014
An efficient Cu-catalyzed decarboxylative C3-acylation of free (N-H) indoles using α-oxocarboxylic acids as acylating agents has been developed. This method was compatible with a variety of functional groups and provided an attractive alternative access to 3-acylindoles in moderate to high yields.
Dara Saidulu S Academy of Scientific and Innovative Research, CSIR-Indian Institute of Integrative Medicine, Jammu 180 001, India; Medicinal Chemistry Division, CSIR-Indian Institute of Integrative Medicine, Jammu 180 001, - - 2014
Here we report a high-yielding method for the regioselective reductive ring opening of 4,6-O-benzylidene acetals of hexapyranosides using inexpensive and robust HClO4-SiO2 as the acidic catalyst and triethylsilane as the hydride donor. Under the optimized condition, gluco- and mannopyranosides give the respective 6-O-benzyl derivative in good to excellent yields while ...
Santala Suvi S Department of Chemistry and Bioengineering, Tampere University of Technology , Tampere 33101, - - 2014
Wax esters are industrially relevant high-value molecules. For sustainable production of wax esters, bacterial cell factories are suggested to replace the chemical processes exploiting expensive starting materials. However, it is well recognized that new sophisticated solutions employing synthetic biology toolbox are required to improve and tune the cellular production platform ...
Wilent Jennifer - - 2014
The desymmetrization of prochiral diesters with a chiral phosphoric acid catalyst to produce highly enantioenriched lactones in excellent yield is reported. The process is easily scaled and accommodates a variety of substitution patterns, many of which result in the generation of an enantioenriched all-carbon quaternary center. Manipulation of lactone product ...
Shartau R B RB Department of Zoology, University of British Columbia, 6270 University Blvd., Vancouver, BC, V6T 1Z4 - - 2014
The evolution of air breathing during the Devonian provided early fishes with bimodal respiration with a stable O2 supply from air. This was, however, probably associated with challenges and trade-offs in terms of acid-base balance and ionoregulation due to reduced gill:water interaction and changes in gill morphology associated with air ...
Sardella Roccaldo R Dipartimento di Scienze Farmaceutiche, Università degli Studi di Perugia, Via Fabretti 48, 06123, Perugia, - - 2014
To the best of our knowledge enantioselective chromatographic protocols on β-amino acids with polysaccharide-based chiral stationary phases (CSPs) have not yet appeared in the literature. Therefore, the primary objective of this work was the development of chromatographic methods based on the use of an amylose derivative CSP (Lux Amylose-2), enabling ...
Gratzl Günther G Johannes Kepler University Linz, Institute for Chemical Technology of Organic Materials, Altenberger Str. 69, 4040 Linz, Austria. Electronic address: - - 2014
The increasing number of antibiotic-resistant bacterial strains has developed into a major health problem. In particular, biofilms are the main reason for hospital-acquired infections and diseases. Once formed, biofilms are difficult to remove as they have specific defense mechanisms against antimicrobial agents. Antimicrobial surfaces must therefore kill or repel bacteria ...
Matthaus B B a Max Rubner-Institut (MRI), Bundesforschungsinstitut für Ernährung und Lebensmittel, Institut für Sicherheit und Qualität bei Getreide , Schützenberg 12, D-32756 Detmold , - - 2014
The oleic acid content of seed oils varied between 21.4% (ATAEM7) and 26.6% (Türksoy). The proportion of linoleic acid of soybean oil ranged from 49.0% (Türksoy) to 53.5% (ATAEM7), while the palmitic acid of oils varied between 9.2% (Adasoy) and 11.2% (Noya). The major tocopherols were ¥-tocopherol, α-tocopherol and δ-tocopherol ...
Lee Heeyoung H Department of Biomedical Science, Daegu University, Gyeongsan 712-714, South Korea; Center for Bio-Nanomaterials, Daegu University, Gyeongsan 712-714, South - - 2014
In this study, we report the intrinsic catalytic activity of graphene oxide (GO) for the non-specific cleavage of proteins. We used bovine serum albumin (BSA) and a recombinant esterase (rEstKp) from the cold-adapted bacterium Pseudomonas mandelii as test proteins. Cleavage of BSA and rEstKp was non-specific regarding amino acid sequence, ...
Mukai Nobuhiko N National Research Institute of Brewing, 3-7-1 Kagamiyama, Higashihiroshima, Hiroshima 739-0046, Japan. Electronic address: - - 2014
Among industrial yeasts used for alcoholic beverage production, most wine and weizen beer yeasts decarboxylate ferulic acid to 4-vinylguaiacol, which has a smoke-like flavor, whereas sake, shochu, top-fermenting, and bottom-fermenting yeast strains lack this ability. However, the factors underlying this difference among industrial yeasts are not clear. We previously confirmed ...
Burchell Richard K RK Department of Companion Animal Clinical Studies, Faculty of Veterinary Science, University of Pretoria, Onderstepoort 0110, South Africa. Electronic address: - - 2014
The acid-base disturbances in canine parvoviral (CPV) enteritis are not well described. In addition, the mechanisms causing these perturbations have not been fully elucidated. The purpose of the present study was to assess acid-base changes in puppies suffering from CPV enteritis, using a modified strong ion model (SIM). The hypothesis ...
Te Vruchte Danielle - - 2014
Lysosomal storage disorders (LSDs) occur at a frequency of 1 in every 5,000 live births and are a common cause of pediatric neurodegenerative disease. The relatively small number of patients with LSDs and lack of validated biomarkers are substantial challenges for clinical trial design. Here, we evaluated the use of ...
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