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Masiewicz Paweł P Department of Microbiology, Ludwik Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Wrocław, - - 2014
During infection of macrophages, Mycobacterium tuberculosis, the pathogen that causes tuberculosis, utilizes fatty acids as a major carbon source. However, little is known about the coordination of the central carbon metabolism of M. tuberculosis with its chromosomal replication, particularly during infection. A recently characterized transcription factor called PrpR is known ...
Chaplin Jason H JH Medicinal Chemistry, Monash Institute of Pharmaceutical Sciences, Monash University , 381 Royal Parade, Parkville, Victoria 3052, - - 2014
Reductive coupling of α,β-unsaturated acid chlorides A with alkynoyls B provides convergent access to Nazarov cyclization precursors, α-carboxy divinyl ketones C. Cyclization of C gives an intermediate oxyallyl cation intermediate D, which can be trapped with tethered arenes (Ar). The resultant products can be further cyclized through nucleophilic displacement of ...
Zou Xiang X College of Pharmaceutical Sciences, Southwest University, 2 Tian Sheng Road, Beibei, Chongqing, 400715, People's Republic of China, - - 2014
Polymalic acid (PMA) is a water-soluble polyester with many attractive properties for biomedical application. Its monomer L-malic acid is widely used in the food industry and also a potential C4 platform chemical. Cofactor and CO2 donor involved in the reductive routes were investigated for PMA production by Aureobasidium pullulans. Biotin ...
Shen Yiru Y Poultry Institute, Chinese Academy of Agricultural Sciences, Yangzhou, Jiangsu 225125, China. - - 2014
Ascites is a major problem for both human health and animal production, due to its association with high rates of morbidity and mortality, low efficiency of nutrient utilization, and permanent adverse effects on performance. Although it is one of the three major metabolic diseases in poultry production, the underlying mechanisms ...
Haitao Qu - - 2014
Abstract Existent nucleic acid isothermal detection techniques for clinical diseases are difficult to promote greatly due to limitations in such aspects as methodology, costs of detection, amplification efficiency and conditions for operation. Therefore, there is an urgent need for a new isothermal amplification method with the characteristics of high accuracy, ...
Sanikommu Suma - - 2014
Phosphate released from phytic acid can be used as a measure of phytase activity. However, most of the phosphate estimation methods have not examined the interference or interaction of phytic acid in the assay. In this article, we report the kinetics and influence of unreduced phytic acid on phosphate estimation ...
Kallas Zein Z Centre for Agro-food Economy and Development (CREDA-UPC-IRTA), Casteldefells, Barcelona, Spain. Electronic address: - - 2014
This paper uses Choice Experiments (CE) to investigate Spanish consumers' preferences towards beef meat enriched with polyunsaturated fatty acids (omega-3 and conjugated linoleic acid). Data were gathered from self-completed questionnaires in a controlled environment with two different samples (320 and 322 consumers) differentiated by the information received. The surveys were ...
Qing Qing Q Department of Biochemical Engineering, College of Pharmaceutical Engineering and Life Science, Changzhou University, Changzhou, Jiangsu, 213164, - - 2014
Pretreatment of lignocellulosic materials is a prerequisite to facilitate the disruption of the natural recalcitrance of their carbohydrate-lignin shield and to allow enzymes to easily access the crystalline cellulose surfaces. Recently, pretreatment of ionic liquids (ILs) has been widely studied as a promising pretreatment technique; however, it is too expensive ...
Sridhar Y Y Division of Natural Products Chemistry, CSIR-Indian Institute of Chemical Technology, Hyderabad-500007, India. - - 2014
A flexible stereoselective approach to the common C1-C14 skeleton present in natural products of the pseudomonic acid family is described. The strategy has been extended and the total synthesis of pseudomonic acid methyl monate C was achieved. The key synthetic reactions utilized include Achmatowicz rearrangement, Johnson-Claisen rearrangement, Julia-Kocienski olefination, and ...
Fauvelle Vincent V Irstea, UR EABX, Laboratoire de Chimie des Eaux, 50 Avenue de Verdun, 33612, Cestas Cedex, - - 2014
This paper presents an optimization of the pharmaceutical Polar Organic Chemical Integrative Sampler (POCIS-200) under controlled laboratory conditions for the sampling of acidic (2,4-dichlorophenoxyacetic acid (2,4-D), acetochlor ethanesulfonic acid (ESA), acetochlor oxanilic acid, bentazon, dicamba, mesotrione, and metsulfuron) and polar (atrazine, diuron, and desisopropylatrazine) herbicides in water. Indeed, the conventional ...
Nano Adela A Laboratoire de Chimie Organique et Spectroscopies Avancées (ICPEES-LCOSA), UMR 7515 au CNRS, Ecole Européenne de Chimie, Polymères et Matériaux, Université de Strasbourg, 25 rue Becquerel, 67087 Strasbourg Cedex 02, France. - - 2014
A new type of fluorescent pH indicator has been developed whereby two dissimilar amino-styryl units are attached to a boron dipyrromethene (Bodipy) dye. The photophysical properties of this hybrid dye, and its simpler counterparts bearing only a single amino-styryl residue, depend on the polarity of the surrounding medium. Of the ...
Wang Gang - - 2014
Previous studies have demonstrated altered metabolites in samples of Alzheimer's disease (AD) patients. However, the sample size from many of them is relatively small and the metabolites are relatively limited. Here we applied a comprehensive platforms using ultra performance liquid chromatography-time-of-flight mass spectrometry and gas chromatography-time-of-flight mass spectrometry to analyze ...
Shen Pengfei - - 2014
For the first time, non-enzymatic blood glucose sensing has been achieved by using fluorescent boronic acid modified carbon dots (C-dots) as the signal readout. The functionalized C-dots are fabricated by one-step hydrothermal carbonization, using phenylboronic acid as the sole precursor. Compared with conventional two-step fabrication of nanoparticle based sensors, the ...
Kur-Kowalska Karolina K Lodz University of Technology, Institute of General Food Chemistry, Stefanowskiego 4/10, 90-924 Lodz, - - 2014
Preliminary results of a study of the interaction between 3-amino phenylboronic acid and glucose or ZnS:Cu quantum dots are presented in this paper. ZnS:Cu quantum dots with mercaptopropionic acid as a capping agent were obtained and characterized. Quenching of 3-amino phenylboronic acid fluorescence was studied by steady-state and timeresolved measurements. ...
Aktas Ayse Burcu AB Izmir Institute of Technology, Department of Food Engineering, Urla, Izmir, - - 2014
Some olives grown in Karaburun peninsula in the west part of Turkey and mostly coming from Erkence variety lose their bitterness while still on the tree and are called Hurma among locals. This olive type does not require further processing to remove the bitter compounds. In this study, sugar, organic ...
Zunk Matthew M Institute for Glycomics, Griffith University Gold Coast Campus, Southport, Queensland 4222, Australia. - - 2014
The pseudaminic acids are a family of 5,7-diamino-3,5,7,9-tetradeoxynonulosonic acids that are essential components of bacterial polysaccharides and glycoproteins. This paper describes our approach towards the synthesis of analogues of pseudaminic acid, and involves the efficient introduction of the requisite nitrogen functionalities from a readily available precursor.
Cabanes Juana - - 2014
Betalains are plant pigments with high antioxidant and cancer chemopreventive properties used by the food industry as safe colorants. Betalains are restricted to species of the order Caryophyllales and difficulty in obtaining individual molecules has limited their structural identification and application. This study was designed to develop a betalamic acid-derivatized ...
Kwantes Jonathan M JM Department of Medicinal Chemistry, College of Pharmacy, University of Florida, Gainesville, Florida, - - 2014
ABSTRACT In the last few years there has been a noticeable increase in both the promotion and research of krill oil for its purported health benefits, including the management and treatment of conditions, such as hyperlipidemia, inflammation, and arthritis. Additionally, because krill oil contains the same omega-3 fatty acids eicosapentaenoic ...
Han Da D Center for Research at Bio/nano Interface, Department of Chemistry and Department of Physiology and Functional Genomics, Shands Cancer Center, UF Genetics Institute and McKnight Brain Institute, University of Florida, Gainesville, FL (USA), Fax: - - 2014
Researchers increasingly visualize a significant role for artificial biochemical logical systems in biological engineering, much like digital logic circuits in electrical engineering. Those logical systems could be utilized as a type of servomechanism to control nanodevices in vitro, monitor chemical reactions in situ, or regulate gene expression in vivo. Nucleic ...
Tedone Laura L Dipartimento di Scienze del Farmaco e dei Prodotti per la Salute, Università degli Studi di Messina, Viale Annunziata, 98168, Messina, - - 2014
Ruta chalepensis L. (Rutaceae) is widespread in the Mediterranean area. This plant has a solid tradition in ethnomedicine because of its various biological activities. Based on previous reports, the main volatile constituents of R. chalepensis are 2-undecanone and 2-nonanone, but most are still unknown, particularly fatty acid composition. To exhaustively ...
Lovelock Sarah L SL School of Chemistry, University of Manchester, Manchester Institute of Biotechnology, 131 Princess Street, Manchester, M1 7DN - - 2014
Phenylalanine ammonia lyases (PALs) belong to a family of 4-methylideneimidazole-5-one (MIO) cofactor dependent enzymes which are responsible for the conversion of L-phenylalanine into trans-cinnamic acid in eukaryotic and prokaryotic organisms. Under conditions of high ammonia concentration, this deamination reaction is reversible and hence there is considerable interest in the development ...
Seiple Ian B IB Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA 02138 - - 2014
β-Hydroxy-α-amino acids figure prominently as chiral building blocks in chemical synthesis and serve as precursors to numerous important medicines. Reported herein is a method for the synthesis of β-hydroxy-α-amino acid derivatives by aldolization of pseudoephenamine glycinamide, which can be prepared from pseudoephenamine in a one-flask protocol. Enolization of (R,R)- or ...
Nygård Yvonne Y VTT Technical Research Centre of Finland, Espoo, - - 2014
Resistance to weak organic acids is important relative to both weak organic acid preservatives and development of inhibitor tolerant yeast as industrial production organisms. The ABC transporter Pdr12 is important for resistance to sorbic and propionic acid, but its role in tolerance to other weak organic acids with industrial relevance ...
Eguchi Kosei K Department of Cardiovascular Medicine, The University of - - 2014
The epidemic growth in the prevalence of obesity has made the impact of metabolic syndrome on cardiovascular events increasingly significant. Elevated visceral adiposity, the indispensable component of metabolic syndrome, is thought to play a primary role in the increasing incidence of cardiometabolic disorders. Importantly, obesity is not merely the simple ...
Yu Zhi-Rui ZR Department of Occupational and Environmental Health, Tianjin Medical University, Tianjin, 300070, China, - - 2014
Metabolic syndrome (MetS) is a serious threat to public health worldwide with an increased risk of developing type 2 diabetes, cardiovascular diseases and all-cause morbidity and mortality. In this study, a urinary metabolomic approach was performed on high performance liquid chromatography quadrupole time-of-flight mass spectrometry to discriminate 36 male MetS ...
Lee L K LK Department of Paediatrics and Adolescent Medicine, Caritas Medical Centre, Shamshuipo, Hong - - 2014
A 15-year-old Chinese male with infantile-onset hypotonia, developmental delay, ptosis, and oculogyric episodes presented with a history of chronic diarrhoea since the age of 5 years. At presentation, he had an exacerbation of diarrhoeal symptoms resulting in dehydration and malnutrition with a concurrent severe chest infection. In view of his ...
Vleggaar Danny - - 2014
Poly-L-lactic acid (PLLA) was first approved for soft tissue augmentation in Europe in 1999 for the cosmetic correction of scars and wrinkles. Due, in part, to inadequate usage recommendations that included those related to product reconstitution and hydration, injection sites, techniques, and timing, and patient selection, PLLA use was initially ...
Burstein Sumner H SH Department of Biochemistry and Molecular Pharmacology, The University of Massachusetts Medical School, Worcester, MA 01605, USA. Electronic address: - - 2014
The cannabinoid acids are a structurally heterogeneous group of compounds some of which are endogenous molecules and others that are metabolites of phytocannabinoids. The prototypic endogenous substance is N-arachidonoyl glycine (NAgly) that is closely related in structure to the cannabinoid agonist anandamide. The most studied phytocannabinoid is Δ(9)-THC-11-oic acid, the ...
Ramesh B N BN Department of Agricultural Biotechnology, Agricultural College, Karekere, Hassan, University of Agricultural Sciences (B), Mysore, Karnataka, - - 2014
Amyloidosis, oxidative stress and inflammation have been strongly implicated in neurodegenerative disorders like Alzheimer's disease. Traditionally, Caesalpinia crista and Centella asiatica leaf extracts are used to treat brain related diseases in India. C. crista is used as a mental relaxant drink as well as to treat inflammatory diseases, whereas C. ...
Rao Archana N AN Department of Pharmaceutics and Pharmaceutical Chemistry, University of Utah, Salt Lake City, UT 84112 - - 2014
Both clinical and analytical metrics produced by microarray-based assay technology have recognized problems in reproducibility, reliability and analytical sensitivity. These issues are often attributed to poor understanding and control of nucleic acid behaviors and properties at solid-liquid interfaces. Nucleic acid hybridization, central to DNA and RNA microarray formats, depends on ...
Bailey Abby M AM UK Health Care, Departments of Pharmacy Services and Pharmacy Practice and Science, University of Kentucky College of Pharmacy, Lexington, Kentucky (Drs Bailey and Baker); and North Carolina Public Health Preparedness and Response, North Carolina Department of Health and Human Services, Raleigh, North Carolina (Dr - - 2014
Trauma-related deaths represent a leading cause of mortality among persons younger than 45 years. A significant percentage of these are secondary to hemorrhage. In trauma, massive and rapid loss of blood creates an imbalance in hemostasis. Mainstays of resuscitation include surgical interventions, restoring intravascular volume, and pharmacologic interventions. Providers continue ...
Chu Chu C State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 210009, - - 2014
To reveal the profile of astragalosides for better quality evaluation of Radix Astragali, this study was aimed to investigate the transformation of astragalosides under different conditions. Seven major astragalosides were selected for evaluation under acidic, neutral and alkaline conditions. The transformation in real plant samples was also examined and the ...
Ibrahim Victor V VA SYD, SE-201 21 Malmö, Sweden. Electronic address: - - 2014
In anaerobic digestion, the production of short-chain fatty acids (SCFAs) can be beneficial or harmful to the overall process, depending on the concentration of accumulated acids. Therefore, the accurate determination of the SCFA concentration in both fresh and stored sludge hydrolysates is important. To select a suitable method for monitoring ...
Michael Botros R BR a Department of Pharmacognosy , Faculty of Pharmacy, Mansoura University (MU) , Mansoura 35516 , - - 2014
A phytochemical investigation on the 5-lipoxygenase (5-LOX) inhibitory methanolic extract of Rudbeckia hirta L. flowers yielded 10 phenolic metabolites, including three phenolic acids, two phenolic acid esters, four flavonol glycosides and a trimethylated flavonol. The structures of the isolated metabolites were determined on the basis of spectroscopic analyses and by ...
Mioni Roberto R Division of Nephrology, Civil and University Hospital, Santa Maria della Misericordia , Udine , - - 2014
Titratable Acidity (TA) in urine can be measured directly or calculated from actual and reference pH, by using the pKa2 6,8 for phosphate. In urine, H2PO4(-) represents the excretion of filtered H2PO4(-), filtrated HPO4(2-) being completely reabsorbed by the proximal tubule (the Van Slyke approach). Since excretion of H2PO4(-) frequently ...
Yang Xiaoyu X Department of Chemistry, University of California , Berkeley, California 94720, United States - - 2014
We report a study involving the successful merger of two separate chiral catalytic cycles: a chiral anion phase-transfer catalysis cycle to activate Selectfluor and an enamine activation cycle, using a protected amino acid as organocatalyst. We have demonstrated the viability of this approach with the direct asymmetric fluorination of α-substituted ...
Bar-Peled Liron L Department of Chemical Physiology, The Scripps Research Institute, La Jolla, CA 92037, - - 2014
The mechanistic target of rapamycin complex I (mTORC1) is a central regulator of cellular and organismal growth, and hyperactivation of this pathway is implicated in the pathogenesis of many human diseases including cancer and diabetes. mTORC1 promotes growth in response to the availability of nutrients, such as amino acids, which ...
Tah Bidisha B Department of Spectroscopy, Indian Association for the Cultivation of Science, Jadavpur, Kolkata 700032, - - 2014
In this article Quantum mechanical (QM) calculations by Density Functional Theory (DFT) have been performed of all amino acids present in bovine insulin. Simulated Raman spectra of those amino acids are compared with their experimental spectra and the major bands are assigned. The results are in good agreement with experiment. ...
Ianni Federica F Department of Pharmaceutical Sciences, University of Perugia, Via del Liceo 1, 06123 Perugia, Italy; Institute of Pharmaceutical Sciences, University of Tübingen, Auf der Morgenstelle 8, 72076 Tübingen, - - 2014
While aliphatic 2-hydroxyalkanoic acids have been more or less successfully enantioseparated with various chiral stationary phases by HPLC and GC, analogous applications on underivatized aliphatic 3-hydroxyalkanoic acids are completely absent in the scientific literature. With the aim of closing this gap, the enantioseparation of 3-hydroxybutyric acid, 3-hydroxydecanoic acid and 3-hydroxymyristic ...
Oupický David D Department of Pharmaceutical Sciences, Center for Drug Delivery and Nanomedicine, University of Nebraska Medical Center, Durham Research Center, 985830 Nebraska Medical Center, Omaha, NE 68198-5830, USA. - - 2014
Polycations that are degradable by reduction of disulfide bonds are developed for applications in delivery of nucleic acids. This Feature Article surveys methods of synthesis of bioreducible polycations and discusses current understanding of the mechanism of action of bioreducible polyplexes. Emphasis is placed on the relationship between the biological redox ...
Zhang Shuai S a College of Food Science , South China Agricultural University , Guangzhou , - - 2014
Tannases, mainly produced by microorganisms, are able to hydrolyze gallotannins, ellagitannins, complex tannins, and gallic acid esters into gallic acid, ellagic acid, glucose or alcohols, and also synthesize gallic acid esters using tannic acid or gallic acid with a variety of alcohols in nonaqueous media. At present, microbial tannases have ...
Wang Jinfan - - 2014
Abstract Applications of N-methyl amino acids (NMAAs) in drug discovery are limited by their low efficiencies of ribosomal incorporation and little is known mechanistically about the steps leading to incorporation. Here, we demonstrate that a synthetic tRNA body based on a natural N-alkyl amino acid carrier, tRNAPro, increases translation incorporation ...
Krkošek W H WH Department of Civil and Resource Engineering, Dalhousie University, 1360 Barrington St. D514, Halifax, Nova Scotia B3H 4R2, Canada. Electronic address: - - 2014
The fate of pharmaceutically active compounds (PhACs) in wastewater treatment systems is an area of increasing concern. Little research has been done to understand this issue in rural or decentralized communities. The objective of this research was to examine the ability of a bench scale nitrifying recirculating biofilter (RBF) to ...
Huynh Michael - - 2014
First-row metals have been a target for the development of oxygen evolution reaction (OER) catalysts because they comprise non-critical elements. We now report a comprehensive electrochemical characterization of manganese oxide (MnOx) over a wide pH range, and establish MnOx as a functionally stable OER catalyst owing to self-healing. Its functional ...
Boiteux Joana J Instituto de Biología Agrícola de Mendoza (IBAM-CONICET), Facultad de Ciencias Agrarias, Universidad Nacional de Cuyo, Mendoza, - - 2014
Phytophthora spp is important in plant pathology due to the importance of the diseases it causes. In olive trees, severe damages are caused by the disease known as "dry branch" occasioned by P. nicotianae, P. citrophthora and P. palmivora. Much effort has been done to find efficient methods of control, ...
Darula Zsuzsanna Z Laboratory of Proteomics Research, Institute of Biochemistry, Biological Research Centre of the Hungarian Academy of Sciences, Szeged, Hungary, - - 2014
Tris(hydroxymethyl)aminomethane (Tris) is one of the most frequently used buffer ingredients. Among other things, it is recommended and is usually used for lectin-based affinity enrichment of glycopeptides. Here we report that sialic acid, a common 'capping' unit in both N- and O-linked glycans may react with this chemical, and this ...
Ledesma-Amaro Rodrigo R Departamento de Microbiología y Genética, Universidad de Salamanca, Campus Miguel de Unamuno, E-37007, Salamanca, - - 2014
Microbial oils represent a sustainable alternative to vegetable oils and animal fats as feedstock for both the chemical and biofuel industries. The applications of microbial oils depends on their fatty acid composition, which is defined by the relative amount of each fatty acid, also considering the length and unsaturations of ...
Curto John M JM Department of Chemistry, Penn Merck High Throughput Experimentation Laboratory, University of Pennsylvania , Philadelphia, Pennsylvania 19104-6323, United - - 2014
The first asymmetric synthesis of α-allyl-α-aryl α-amino acids by means of a three-component coupling of α-iminoesters, Grignard reagents, and cinnamyl acetate is reported. Notably, the enolate from the tandem process provides a much higher level of reactivity and selectivity than the same enolate generated via direct deprotonation, presumably due to ...
Capitani Donatella D Istituto di Metodologie Chimiche, Laboratorio di Risonanza Magnetica "Annalaura Segre", CNR, I-00015 Monterotondo, Rome, - - 2014
An NMR analytical protocol based on complementary high and low field measurements is proposed for blueberry characterization. Untargeted NMR metabolite profiling of blueberries aqueous and organic extracts as well as targeted NMR analysis focused on anthocyanins and other phenols are reported. Bligh-Dyer and microwave-assisted extractions were carried out and compared ...
Nehdi Imededdine Arbi IA King Saud Univ., College of Science, Chemistry Dept., Riyadh 1145, Saudi - - 2014
Chamaerops humilis L. var. argentea André (C. humilis) date palm seeds are an underutilized source of vegetable oil, and no studies describing their physicochemical characteristics to indicate the potential uses of this seed or seed oil have been reported. The oil content of the seeds is about 10%, mainly composed ...
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