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Kwantes Jonathan M JM Department of Medicinal Chemistry, College of Pharmacy, University of Florida, Gainesville, Florida, - - 2014
ABSTRACT In the last few years there has been a noticeable increase in both the promotion and research of krill oil for its purported health benefits, including the management and treatment of conditions, such as hyperlipidemia, inflammation, and arthritis. Additionally, because krill oil contains the same omega-3 fatty acids eicosapentaenoic ...
Han Da D Center for Research at Bio/nano Interface, Department of Chemistry and Department of Physiology and Functional Genomics, Shands Cancer Center, UF Genetics Institute and McKnight Brain Institute, University of Florida, Gainesville, FL (USA), Fax: - - 2014
Researchers increasingly visualize a significant role for artificial biochemical logical systems in biological engineering, much like digital logic circuits in electrical engineering. Those logical systems could be utilized as a type of servomechanism to control nanodevices in vitro, monitor chemical reactions in situ, or regulate gene expression in vivo. Nucleic ...
Tedone Laura L Dipartimento di Scienze del Farmaco e dei Prodotti per la Salute, Università degli Studi di Messina, Viale Annunziata, 98168, Messina, - - 2014
Ruta chalepensis L. (Rutaceae) is widespread in the Mediterranean area. This plant has a solid tradition in ethnomedicine because of its various biological activities. Based on previous reports, the main volatile constituents of R. chalepensis are 2-undecanone and 2-nonanone, but most are still unknown, particularly fatty acid composition. To exhaustively ...
Lovelock Sarah L SL School of Chemistry, University of Manchester, Manchester Institute of Biotechnology, 131 Princess Street, Manchester, M1 7DN - - 2014
Phenylalanine ammonia lyases (PALs) belong to a family of 4-methylideneimidazole-5-one (MIO) cofactor dependent enzymes which are responsible for the conversion of L-phenylalanine into trans-cinnamic acid in eukaryotic and prokaryotic organisms. Under conditions of high ammonia concentration, this deamination reaction is reversible and hence there is considerable interest in the development ...
Seiple Ian B IB Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA 02138 - - 2014
β-Hydroxy-α-amino acids figure prominently as chiral building blocks in chemical synthesis and serve as precursors to numerous important medicines. Reported herein is a method for the synthesis of β-hydroxy-α-amino acid derivatives by aldolization of pseudoephenamine glycinamide, which can be prepared from pseudoephenamine in a one-flask protocol. Enolization of (R,R)- or ...
Nygård Yvonne Y VTT Technical Research Centre of Finland, Espoo, - - 2014
Resistance to weak organic acids is important relative to both weak organic acid preservatives and development of inhibitor tolerant yeast as industrial production organisms. The ABC transporter Pdr12 is important for resistance to sorbic and propionic acid, but its role in tolerance to other weak organic acids with industrial relevance ...
Eguchi Kosei K Department of Cardiovascular Medicine, The University of - - 2014
The epidemic growth in the prevalence of obesity has made the impact of metabolic syndrome on cardiovascular events increasingly significant. Elevated visceral adiposity, the indispensable component of metabolic syndrome, is thought to play a primary role in the increasing incidence of cardiometabolic disorders. Importantly, obesity is not merely the simple ...
Yu Zhi-Rui ZR Department of Occupational and Environmental Health, Tianjin Medical University, Tianjin, 300070, China, - - 2014
Metabolic syndrome (MetS) is a serious threat to public health worldwide with an increased risk of developing type 2 diabetes, cardiovascular diseases and all-cause morbidity and mortality. In this study, a urinary metabolomic approach was performed on high performance liquid chromatography quadrupole time-of-flight mass spectrometry to discriminate 36 male MetS ...
Lee L K LK Department of Paediatrics and Adolescent Medicine, Caritas Medical Centre, Shamshuipo, Hong - - 2014
A 15-year-old Chinese male with infantile-onset hypotonia, developmental delay, ptosis, and oculogyric episodes presented with a history of chronic diarrhoea since the age of 5 years. At presentation, he had an exacerbation of diarrhoeal symptoms resulting in dehydration and malnutrition with a concurrent severe chest infection. In view of his ...
Vleggaar Danny - - 2014
Poly-L-lactic acid (PLLA) was first approved for soft tissue augmentation in Europe in 1999 for the cosmetic correction of scars and wrinkles. Due, in part, to inadequate usage recommendations that included those related to product reconstitution and hydration, injection sites, techniques, and timing, and patient selection, PLLA use was initially ...
Burstein Sumner H SH Department of Biochemistry and Molecular Pharmacology, The University of Massachusetts Medical School, Worcester, MA 01605, USA. Electronic address: - - 2014
The cannabinoid acids are a structurally heterogeneous group of compounds some of which are endogenous molecules and others that are metabolites of phytocannabinoids. The prototypic endogenous substance is N-arachidonoyl glycine (NAgly) that is closely related in structure to the cannabinoid agonist anandamide. The most studied phytocannabinoid is Δ(9)-THC-11-oic acid, the ...
Ramesh B N BN Department of Agricultural Biotechnology, Agricultural College, Karekere, Hassan, University of Agricultural Sciences (B), Mysore, Karnataka, - - 2014
Amyloidosis, oxidative stress and inflammation have been strongly implicated in neurodegenerative disorders like Alzheimer's disease. Traditionally, Caesalpinia crista and Centella asiatica leaf extracts are used to treat brain related diseases in India. C. crista is used as a mental relaxant drink as well as to treat inflammatory diseases, whereas C. ...
Rao Archana N AN Department of Pharmaceutics and Pharmaceutical Chemistry, University of Utah, Salt Lake City, UT 84112 - - 2014
Both clinical and analytical metrics produced by microarray-based assay technology have recognized problems in reproducibility, reliability and analytical sensitivity. These issues are often attributed to poor understanding and control of nucleic acid behaviors and properties at solid-liquid interfaces. Nucleic acid hybridization, central to DNA and RNA microarray formats, depends on ...
Bailey Abby M AM UK Health Care, Departments of Pharmacy Services and Pharmacy Practice and Science, University of Kentucky College of Pharmacy, Lexington, Kentucky (Drs Bailey and Baker); and North Carolina Public Health Preparedness and Response, North Carolina Department of Health and Human Services, Raleigh, North Carolina (Dr - - 2014
Trauma-related deaths represent a leading cause of mortality among persons younger than 45 years. A significant percentage of these are secondary to hemorrhage. In trauma, massive and rapid loss of blood creates an imbalance in hemostasis. Mainstays of resuscitation include surgical interventions, restoring intravascular volume, and pharmacologic interventions. Providers continue ...
Chu Chu C State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 210009, - - 2014
To reveal the profile of astragalosides for better quality evaluation of Radix Astragali, this study was aimed to investigate the transformation of astragalosides under different conditions. Seven major astragalosides were selected for evaluation under acidic, neutral and alkaline conditions. The transformation in real plant samples was also examined and the ...
Michael Botros R BR a Department of Pharmacognosy , Faculty of Pharmacy, Mansoura University (MU) , Mansoura 35516 , - - 2014
A phytochemical investigation on the 5-lipoxygenase (5-LOX) inhibitory methanolic extract of Rudbeckia hirta L. flowers yielded 10 phenolic metabolites, including three phenolic acids, two phenolic acid esters, four flavonol glycosides and a trimethylated flavonol. The structures of the isolated metabolites were determined on the basis of spectroscopic analyses and by ...
Mioni Roberto R Division of Nephrology, Civil and University Hospital, Santa Maria della Misericordia , Udine , - - 2014
Titratable Acidity (TA) in urine can be measured directly or calculated from actual and reference pH, by using the pKa2 6,8 for phosphate. In urine, H2PO4(-) represents the excretion of filtered H2PO4(-), filtrated HPO4(2-) being completely reabsorbed by the proximal tubule (the Van Slyke approach). Since excretion of H2PO4(-) frequently ...
Yang Xiaoyu X Department of Chemistry, University of California , Berkeley, California 94720, United States - - 2014
We report a study involving the successful merger of two separate chiral catalytic cycles: a chiral anion phase-transfer catalysis cycle to activate Selectfluor and an enamine activation cycle, using a protected amino acid as organocatalyst. We have demonstrated the viability of this approach with the direct asymmetric fluorination of α-substituted ...
Bar-Peled Liron L Department of Chemical Physiology, The Scripps Research Institute, La Jolla, CA 92037, - - 2014
The mechanistic target of rapamycin complex I (mTORC1) is a central regulator of cellular and organismal growth, and hyperactivation of this pathway is implicated in the pathogenesis of many human diseases including cancer and diabetes. mTORC1 promotes growth in response to the availability of nutrients, such as amino acids, which ...
Tah Bidisha B Department of Spectroscopy, Indian Association for the Cultivation of Science, Jadavpur, Kolkata 700032, - - 2014
In this article Quantum mechanical (QM) calculations by Density Functional Theory (DFT) have been performed of all amino acids present in bovine insulin. Simulated Raman spectra of those amino acids are compared with their experimental spectra and the major bands are assigned. The results are in good agreement with experiment. ...
Ianni Federica F Department of Pharmaceutical Sciences, University of Perugia, Via del Liceo 1, 06123 Perugia, Italy; Institute of Pharmaceutical Sciences, University of Tübingen, Auf der Morgenstelle 8, 72076 Tübingen, - - 2014
While aliphatic 2-hydroxyalkanoic acids have been more or less successfully enantioseparated with various chiral stationary phases by HPLC and GC, analogous applications on underivatized aliphatic 3-hydroxyalkanoic acids are completely absent in the scientific literature. With the aim of closing this gap, the enantioseparation of 3-hydroxybutyric acid, 3-hydroxydecanoic acid and 3-hydroxymyristic ...
Oupický David D Department of Pharmaceutical Sciences, Center for Drug Delivery and Nanomedicine, University of Nebraska Medical Center, Durham Research Center, 985830 Nebraska Medical Center, Omaha, NE 68198-5830, USA. - - 2014
Polycations that are degradable by reduction of disulfide bonds are developed for applications in delivery of nucleic acids. This Feature Article surveys methods of synthesis of bioreducible polycations and discusses current understanding of the mechanism of action of bioreducible polyplexes. Emphasis is placed on the relationship between the biological redox ...
Zhang Shuai S a College of Food Science , South China Agricultural University , Guangzhou , - - 2014
Tannases, mainly produced by microorganisms, are able to hydrolyze gallotannins, ellagitannins, complex tannins, and gallic acid esters into gallic acid, ellagic acid, glucose or alcohols, and also synthesize gallic acid esters using tannic acid or gallic acid with a variety of alcohols in nonaqueous media. At present, microbial tannases have ...
Wang Jinfan - - 2014
Abstract Applications of N-methyl amino acids (NMAAs) in drug discovery are limited by their low efficiencies of ribosomal incorporation and little is known mechanistically about the steps leading to incorporation. Here, we demonstrate that a synthetic tRNA body based on a natural N-alkyl amino acid carrier, tRNAPro, increases translation incorporation ...
Krkošek W H WH Department of Civil and Resource Engineering, Dalhousie University, 1360 Barrington St. D514, Halifax, Nova Scotia B3H 4R2, Canada. Electronic address: - - 2014
The fate of pharmaceutically active compounds (PhACs) in wastewater treatment systems is an area of increasing concern. Little research has been done to understand this issue in rural or decentralized communities. The objective of this research was to examine the ability of a bench scale nitrifying recirculating biofilter (RBF) to ...
Huynh Michael - - 2014
First-row metals have been a target for the development of oxygen evolution reaction (OER) catalysts because they comprise non-critical elements. We now report a comprehensive electrochemical characterization of manganese oxide (MnOx) over a wide pH range, and establish MnOx as a functionally stable OER catalyst owing to self-healing. Its functional ...
Boiteux Joana J Instituto de Biología Agrícola de Mendoza (IBAM-CONICET), Facultad de Ciencias Agrarias, Universidad Nacional de Cuyo, Mendoza, - - 2014
Phytophthora spp is important in plant pathology due to the importance of the diseases it causes. In olive trees, severe damages are caused by the disease known as "dry branch" occasioned by P. nicotianae, P. citrophthora and P. palmivora. Much effort has been done to find efficient methods of control, ...
Darula Zsuzsanna Z Laboratory of Proteomics Research, Institute of Biochemistry, Biological Research Centre of the Hungarian Academy of Sciences, Szeged, Hungary, - - 2014
Tris(hydroxymethyl)aminomethane (Tris) is one of the most frequently used buffer ingredients. Among other things, it is recommended and is usually used for lectin-based affinity enrichment of glycopeptides. Here we report that sialic acid, a common 'capping' unit in both N- and O-linked glycans may react with this chemical, and this ...
Ledesma-Amaro Rodrigo R Departamento de Microbiología y Genética, Universidad de Salamanca, Campus Miguel de Unamuno, E-37007, Salamanca, - - 2014
Microbial oils represent a sustainable alternative to vegetable oils and animal fats as feedstock for both the chemical and biofuel industries. The applications of microbial oils depends on their fatty acid composition, which is defined by the relative amount of each fatty acid, also considering the length and unsaturations of ...
Curto John M JM Department of Chemistry, Penn Merck High Throughput Experimentation Laboratory, University of Pennsylvania , Philadelphia, Pennsylvania 19104-6323, United - - 2014
The first asymmetric synthesis of α-allyl-α-aryl α-amino acids by means of a three-component coupling of α-iminoesters, Grignard reagents, and cinnamyl acetate is reported. Notably, the enolate from the tandem process provides a much higher level of reactivity and selectivity than the same enolate generated via direct deprotonation, presumably due to ...
Capitani Donatella D Istituto di Metodologie Chimiche, Laboratorio di Risonanza Magnetica "Annalaura Segre", CNR, I-00015 Monterotondo, Rome, - - 2014
An NMR analytical protocol based on complementary high and low field measurements is proposed for blueberry characterization. Untargeted NMR metabolite profiling of blueberries aqueous and organic extracts as well as targeted NMR analysis focused on anthocyanins and other phenols are reported. Bligh-Dyer and microwave-assisted extractions were carried out and compared ...
Nehdi Imededdine Arbi IA King Saud Univ., College of Science, Chemistry Dept., Riyadh 1145, Saudi - - 2014
Chamaerops humilis L. var. argentea André (C. humilis) date palm seeds are an underutilized source of vegetable oil, and no studies describing their physicochemical characteristics to indicate the potential uses of this seed or seed oil have been reported. The oil content of the seeds is about 10%, mainly composed ...
Tamulis Arvydas A Institute of Theoretical Physics and Astronomy, Vilnius University, A. Gostauto 12, Vilnius, - - 2014
This paper contains the review of quantum entanglement investigations in living systems, and in the quantum mechanically modelled photoactive prebiotic kernel systems. We define our modelled self-assembled supramolecular photoactive centres, composed of one or more sensitizer molecules, precursors of fatty acids and a number of water molecules, as a photoactive ...
Igoli John O - - 2014
Chemical investigation of the lichen Cetraria islandica has led to the isolation of four compounds identified as protolichesterinic acid, lichesterinic acid, protocetraric acid and fumarprotocetraric acid. Their structures were characterized using their physical and spectroscopic data. Using an AlamarblueTM 96 well microplate assay, these compounds were tested to evaluate their ...
Nilsson Robert R Division of Chemical Engineering, Luleå University of Technology, SE-971 87 Luleå, Sweden. Electronic address: - - 2014
This paper presents a novel process for n-butanol production which combines a fermentation consuming carbon dioxide (succinic acid fermentation) with subsequent catalytic reduction steps to add hydrogen to form butanol. Process simulations in Aspen Plus have been the basis for the techno-economic analyses performed. The overall economy for the novel ...
Ryckebosch Eline E KU Leuven Kulak, Research Unit Food & Lipids, Department of Molecular and Microbial Systems Kulak, Leuven Food Science and Nutrition Research Centre (LFoRCe), Etienne Sabbelaan 53, 8500 Kortrijk, - - 2014
The purpose of this work was to evaluate the nutritional value of the total lipid extract of different omega-3 long chain polyunsaturated fatty acids producing photoautotrophic microalgae in one study. It was shown that microalgae oils from Isochrysis, Nannochloropsis, Phaeodactylum, Pavlova and Thalassiosira contain sufficient omega-3 LC-PUFA to serve as ...
Abbet Christian C Division of Pharmaceutical Biology, Department of Pharmaceutical Sciences, University of Basel, Klingelbergstrasse 50, CH-4056 Basel, - - 2014
Plants which have been traditionally eaten by alpine populations may provide new opportunities of agricultural development for mountain regions. In this context we investigated the chemical composition of Cirsium spinosissimum (Asteraceae), a perennial thistle. Its receptacles were eaten by shepherds in Valais (Switzerland). Extracts of aerial parts were subjected to ...
Obruca Stanislav S Materials Research Centre, Faculty of Chemistry, Brno University of Technology, Purkynova 118, Brno, 612 00, Czech Republic, - - 2014
Spent coffee grounds (SCG), an important waste product of the coffee industry, contain approximately 15 wt% of coffee oil. The aim of this work was to investigate the utilization of oil extracted from SCG as a substrate for the production of poly(3-hydroxybutyrate) (PHB) by Cupriavidus necator H16. When compared to other ...
Wu Jiaxi J Department of Molecular Biology - - 2014
The innate immune system utilizes pattern-recognition receptors (PRRs) to detect the invasion of pathogens and initiate host antimicrobial responses such as the production of type I interferons and proinflammatory cytokines. Nucleic acids, which are essential genetic information carriers for all living organisms including viral, bacterial, and eukaryotic pathogens, are major ...
Dessì Mariarita - - 2014
Dyslipidemia and abnormal phospholipid metabolism are frequent in uremic patients and increase their risk of cardiovascular disease (CVD): omega-3 polyunsaturated fatty acids (PUFAs) may reduce this risk in the general population. In this study we compared the plasma and erythrocyte cell membrane composition of PUFAs in a group of Caucasian ...
Nadvorny Daniela - - 2014
Usnic acid is a secondary metabolite found in several species of lichens, organisms resulting from the symbiosis between fungi and algae. This compound has been extensively studied due of its pharmacological properties. Despite its potential medicinal importance, it exhibits a high degree of toxicity. The confinement of the usnic acid ...
Lv Zesheng Z Department of Polymer Science and Technology, School of Chemical Engineering and Technology, Tianjin University, Tianjin 300072, - - 2014
In this work, a new hydrogel was constructed using poly(ɛ-caprolactone-co-1,4,8-trioxa[4.6]spiro-9-undecanone)-poly(ethylene glycol)-poly(ɛ-caprolactone-co-1,4,8-trioxa[4.6]spiro-9-undecanone) tri-block copolymers (PECT) with hyaluronic acid (HA) in order to expand application scopes of PECT hydrogel. The rheological and sol-gel phase transition behaviors were investigated by rheometer and test tube inversion method, and the interior morphologies of hydrogel systems ...
Tang Xiaoling X School of Chemical and Biomedical Engineering, College of Engineering, Nanyang Technological University, 62 Nanyang Drive, Singapore 637459, - - 2014
In this study, the Saccharomyces cerevisiae wild type strain and engineered strain with an overexpressed heterologous ATP-citrate lyase (acl) were cultured in medium with different carbon and nitrogen concentrations, and their fatty acid production levels were investigated. The results showed that when the S. cerevisiae engineered strain was cultivated under ...
Taghvaei Mostafa M Department of Food Materials and Process Design Engineering, Faculty of Food Science and Technology, University of Agricultural Sciences and Natural Resources, Gorgan, Iran. Electronic address: - - 2014
Microwave assisted extraction (MAE) is a novel method, which can reduce the extraction time and solvent consumption. This study aimed to evaluate the influence of MAE on oxidative stability and physicochemical properties of cottonseed oil. We found that the optimum extraction conditions were: irradiation time 3.57min; cottonseed moisture content 14% ...
Zha Ying - - 2014
Inhibitors are formed that reduce the fermentation performance of fermenting yeast during the pretreatment process of lignocellulosic biomass. An exometabolomics approach was applied to systematically identify inhibitors in lignocellulosic biomass hydrolysates. We studied the composition and fermentability of 24 different biomass hydrolysates. To create diversity, the 24 hydrolysates were prepared ...
Sułkowska-Ziaja Katarzyna K Department of Pharmaceutical Botany, Faculty of Pharmacy, Jagiellonian University Medical College, Medyczna 9, 30-688 Kraków, Poland. Electronic address: - - 2014
Phylum Basidiomycota fungal species are of great interest in many studies as a source of valuable biological compounds. The estimation of the levels of antioxidant compounds (phenolic acids, indole compounds and sterols) in edible species of Aphyllophorales (sensu lato): Hydnum repandum L. and Sparassis crispa (Wulf.) Fr. A reversed-phase high ...
Zhang Tong T Chiral Technologies Europe, Bd. Gonthier d'Andernach, 67400, Illkirch, - - 2014
An extensive series of free amino acids and analogues were directly resolved into enantiomers (and stereoisomers where appropriate) by HPLC on zwitterionic chiral stationary phases (Chiralpak ZWIX(+) and Chiralpak ZWIX(-)). The interaction and chiral recognition mechanisms were based on the synergistic double ion-paring process between the analyte and the chiral ...
Lemercier Bérénice C BC Department of Chemistry, North Carolina State University , Raleigh, North Carolina 27695, United - - 2014
A copper catalyzed aminobromination of alkene tethered thiohydroximic acids is described, providing a rapid approach to unnatural thiazoline scaffolds not readily available via existing methods. Moderate to high yields of bromothiazolines are obtained with alkyl- and aryl-substituted thiohydroximic acid building blocks containing mono-, di-, and trisubstituted alkenes. The reaction provides ...
Szoka Francis C - - 2014
Herein, we describe an efficient and high-yielding method to synthesize hyaluronan oligosaccharide-lipid conjugates. This strategy is based on first covalently attaching diphytanoyl glycerophosphatidylethanolamine (DiPhPE) to commercially available high molecular weight hyaluronic acid (HA), via the carboxylate group of the glucuronic acid using carbodiimide chemistry. The HA-lipid conjugate mixture is then ...
Deng Yongming Y Department of Chemistry and Biochemistry, Miami University, Oxford, OH 45056, USA. - - 2014
Synergistic-cooperative combination of enamine catalysis with transition metal catalysis is an emerging and exciting field aiming to achieve organic transformations that cannot be accomplished by individual catalysis. The biggest obstacle in this field lies in the catalyst incompatibility arising from Lewis acid-Lewis base interactions. Several strategies including soft/hard combination of ...
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