Search Results
Results 301 - 350 of 3552
< 2 3 4 5 6 7 8 9 10 11 12 >
Tenca Andrea A Gastroenterology Unit 2, Università degli Studi di Milano and Fondazione IRCCS "Ca' Granda" - Ospedale Maggiore Policlinico, Milan, - - 2014
Symptom reflux association analysis is especially helpful for evaluation and management of proton pump inhibitor (PPI) re-fractory patients. An accurate calculation requires manual editing of 24-hour multichannel intraluminal impedance-pH (MII-pH) tracings after automatic analysis. Intra- and inter-observer agreement as well as reliability of rapid editing confined to the time around ...
Malcher Jakub - - 2014
Peptide Nucleic Acids (PNAs) are molecules combining structural features of proteins and nucleic acid. They resemble DNA or RNA by forming helical polyamides containing nitrogen bases attached to the backbone consisting of N-(2-aminoethyl)-glycine monomers, which mimics the alternating ribose-phosphodiester-backbone of a nucleic acid. Because PNAs bind exceptionally strong to complementary ...
Clausen Morten R - - 2014
Genetic variation is the most influential factor for carrot (Daucus carota L.) composition. However, difference in metabolite content between carrot varieties has not been described by NMR although primary metabolites are important for human health and sensory properties. The aim of the present study was to investigate the effect of ...
Mee Michael T MT Department of Biomedical Engineering, Boston University, Boston, MA - - 2014
Metabolic crossfeeding is an important process that can broadly shape microbial communities. However, little is known about specific crossfeeding principles that drive the formation and maintenance of individuals within a mixed population. Here, we devised a series of synthetic syntrophic communities to probe the complex interactions underlying metabolic exchange of ...
Kovash Curtiss S CS Jr Department of Coatings and Polymeric Materials, North Dakota State University, PO Box 6050, Dept 2760, Fargo, ND 58108 - - 2014
A new 100 % bio-based thermosetting coating system was developed from epoxidized sucrose soyate crosslinked with blocked bio-based dicarboxylic acids. A solvent-free, green method was used to block the carboxylic acid groups and render the acids miscible with the epoxy resin. The thermal reversibility of this blocking allowed for the formulation ...
Leskey Tracy C - - 2014
Plum curculio, Conotrachelus nenuphar (Herbst), one of the most important pests of apple in eastern and central North America, is usually managed in New England apple orchards by multiple full-block insecticide applications. Efforts to reduce insecticide inputs against plum curculio include using an "attract and kill" approach: odor-baited trap trees ...
Diesendruck Charles E CE 1] Department of Chemistry, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801, USA [2] Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801, - - 2014
Biological systems rely on recyclable materials resources such as amino acids, carbohydrates and nucleic acids. When biomaterials are damaged as a result of aging or stress, tissues undergo repair by a depolymerization-repolymerization sequence of remodelling. Integration of this concept into synthetic materials systems may lead to devices with extended lifetimes. ...
Ng Carla A CA Safety and Environmental Technology Group, Institute for Chemical and Bioengineering, ETH Zurich , Zurich 8093, - - 2014
In this review, we consider the two prevailing hypotheses for the mechanisms that control the bioaccumulation of perfluorinated alkyl acids (PFAAs). The first assumes that partitioning to membrane phospholipids, which have a higher affinity for charged species than neutral storage lipids, can explain the high bioaccumulation potential of these compounds. ...
Ottosson N N FOM Institute AMOLF, Science Park 104, 1098 XG Amsterdam, The Netherlands. ottosson@amolf.nl - - 2014
We study the conformation and reorientation dynamics of the inhibitory neurotransmitter γ-aminobutyric acid (GABA) under neutral and acidic conditions using a combination of broadband dielectric relaxation spectroscopy and polarization-resolved femtosecond mid-infrared pump-probe spectroscopy. We find that both zwitterionic and cationic GABA adopt nearly linear conformations in aqueous solution, meaning that ...
Dydio Paweł P van 't Hoff Institute for Molecular Sciences, University of Amsterdam, Amsterdam, The - - 2014
This protocol describes how to prepare 2-(2-formylalkyl)-arenecarboxylic acid derivatives, common building blocks for the synthesis of various valuable chemicals (e.g., anti-obesity and Alzheimer's disease treatment pharmaceuticals), by using the fully regioselective hydroformylation of vinyl arene derivatives. This catalytic reaction proceeds cleanly with 100% regioselectivity and chemoselectivity. The procedure is reliably ...
Xu Jiacui J Ernst Moritz Arndt Universität Greifswald, Institut für Biochemie, Felix Hausdorff Strasse 4, 17487 Greifswald (Germany); Current address: Department of Biochemistry, University of Wisconsin, 433 Babcock Drive, Madison, WI 53706 - - 2014
In the transition from the RNA world to the modern DNA/protein world, RNA-catalyzed aminoacylation might have been a key step towards early translation. A number of ribozymes capable of aminoacylating their own 3' termini have been developed by in vitro selection. However, all of those catalysts require a previously activated ...
Le Tien Xuan TX Université Paris-Sud and CNRS, Laboratoire de Synthèse de Biomolécules, Institut de Chimie Moléculaire et des Matériaux d'Orsay, UMR 8182, 91405 Orsay (France); Department of Chemical Engineering, HCMC University of Technology, VNU-HCM, 268 Ly Thuong Kiet, District 10, Ho Chi Minh City - - 2014
The umpolung of glycals with samarium diiodide offers a simple route to novel carbohydrate-derived nucleophilic reagents in a single step using a readily available reductant. The corresponding allyl samarium reagent that arises from the hexose series reacts with ketones at the C3 position with high stereoselectivity; carbon-carbon bond formation takes ...
Chandra Suman - - 2014
Two new chemically stable functional crystalline COFs (Tp-Azo and Tp-Stb) were synthesized using the Schiff base reaction between triformylphloroglucinol (Tp) and 4,4'-azodianiline (Azo) or 4,4'-diaminostilbene (Stb), respectively. Both COFs show the expected keto-enamine form, and high stability towards boiling water, strong acidic and basic media. H3PO4 doping in Tp-Azo leads ...
Escudero-Casao Margarita - - 2014
In recent years, peptidomimetics have gained enormous importance in drug design aiming to achieve increased drug metabolic stability and higher selectivity. In the field of peptidomimetics, β-peptides incorporating β2- and β3-amino acids (the higher homologs of natural β-amino acids) provide a powerful method for the synthesis of peptidomimetics with particular ...
Gangidi Rahul Reddy RR Lipid Science and Traditional Foods Dept, CSIR Central Food Technological Research Inst. (CFTRI), Mysore, Karnataka, 570020, - - 2014
Conjugated linoleic acid (CLA) that is commonly found in dairy and ruminant fats, is geometrical and positional isomer of linoleic acid (LA). Edible oils are not good sources of CLA. Attempts have been made to generate CLA in edible oils through photoisomerization procedures. CLA isomers have several proven health benefits. ...
Alonso Saúl S Department of Chemical Engineering and Environmental Technology, Faculty of Chemistry, University of Oviedo , Oviedo , - - 2014
Abstract Microbial production of organic acids has become a fast-moving field due to the increasing role of these compounds as platform chemicals. In recent years, the portfolio of specialty fermentation-derived carboxylic acids has increased considerably, including the production of glyceric, glucaric, succinic, butyric, xylonic, fumaric, malic, itaconic, lactobionic, propionic and ...
Sbihi Hassen Mohamed HM King Saud Univ, College of Science, Chemistry Dept, P.O. BOX 2454, Riyadh 1145, Saudi - - 2014
Seed oils with high polyunsaturated fatty acid content are used in various industries including the food and pharmaceutical industries. White mahlab (Prunus mahaleb L.) seed was found to contain 31% oil. The oil was highly polyunsaturated and abundant in α-eleostearic (38.32%), oleic (31.29%), and linoleic (22.96%) acids, which together comprised ...
Badenhorst Christoffel Petrus Stephanus CP Biochemistry Division, Centre for Human Metabonomics, North-West University , Potchefstroom , South - - 2014
Abstract A number of endogenous and xenobiotic organic acids are conjugated to glycine, in animals ranging from mosquitoes to humans. Glycine conjugation has generally been assumed to be a detoxification mechanism, increasing the water solubility of organic acids in order to facilitate urinary excretion. However, the recently proposed glycine deportation ...
Astakhova I Kira IK Nucleic Acid Center, Department of Physics, Chemistry and Pharmacy, University of Southern Denmark , Campusvej 55, DK-5230 Odense M, - - 2014
Conspectus Incorporation of chemically modified nucleotide scaffolds into nucleic acids to form assemblies rich in function is an innovative area with great promise for nanotechnology and biomedical and material science applications. The intrinsic biorecognition potential of nucleic acids combined with advanced properties of the locked nucleic acids (LNAs) provide opportunities ...
Lorente José J IBMC-JBT Corp., FoodTech R&D Alliance, Instituto de Biología Molecular y Celular, Universidad Miguel Hernández (UMH) - Campus de Orihuela, Carretera de Beniel km 3.2, 03312 Orihuela, Alicante, - - 2014
To contribute for setting reference guideline for commercial juice extracted from the Spanish lemon varieties, chemical composition of 92 direct and 92 reconstituted samples were investigated. In direct lemon juice, titratable acidity was 52.4g/L, being the citric acid the main component. Glucose, fructose and sucrose concentrations were 7.9, 7.3 and ...
Sun Li-Jun LJ Institute of Analytical Chemistry for Life Science, School of Public Health, Nantong University, 9 Seyuan Rd., Nantong, Jiangsu 226019, People's Republic of - - 2014
Detection of phytohormones in situ has gained significant attention due to their critical roles in regulating developmental processes and signaling for defenses in plants at low concentration. As one type of plant hormones, salicylic acid has recently been found to be one of pivotal signal molecules for physiological behaviors of ...
Tiboni Marcela M Department of Pharmacy, Federal University of Paraná (UFPR), Curitiba, PR, 80210-170, - - 2014
Ligno(hemi)cellulosics (L(h)Cs) as sugarcane bagasse and loblolly pine sawdust are currently being used to produce biofuels such as bioethanol and biobutanol through fermentation of free sugars that are often obtained enzymatically. However, this bioconversion requires a pretreatment to solubilize the hemicellulose fractions, thus facilitating the action of the cellulolytic enzymes. ...
Xie Neng-Zhong NZ State Key Laboratory of Non-food Biomass Energy and Enzyme Technology, National Engineering Research Center for Non-food Biorefinery, Guangxi Academy of Sciences, Nanning 530007, Guangxi, People's Republic of - - 2014
Muconic acid (MA), a high value-added bio-product with reactive dicarboxylic groups and conjugated double bonds, has garnered increasing interest owing to its potential applications in the manufacture of new functional resins, bio-plastics, food additives, agrochemicals, and pharmaceuticals. At the very least, MA can be used to produce commercially important bulk ...
Calce Enrica E Institute of Biostructures and Bioimaging, National Research Council, 80134 Naples, - - 2014
Several pectin derivatives were prepared by chemical modifications of the polysaccharide with natural fatty acids. The obtained biodegradable pectin-based materials, pectin-linoleate, pectin-oleate and pectin-palmitate, were investigated for their antimicrobial activity against several bacterial strains, Staphylococcus aureus and Escherichia coli. Good results were obtained for pectin-oleate and pectin-linoleate, which inhibit the ...
López Garzón Camilo S CS Delft University of Technology, Department of Biotechnology, Julianalaan 67, 2628 BC Delft, the - - 2014
Carboxylic acids such as citric, lactic, succinic and itaconic acid are useful products and are obtained on large scale by fermentation. This review describes the options for recovering these and other fermentative carboxylic acids. After cell removal, often a primary recovery step is performed, using liquid-liquid extraction, adsorption, precipitation or ...
Neerathilingam Muniasamy M Institute of Molecular Medicine, The University of Texas Health Sciences Centre at Houston, 1825 Pressler Street, Houston, TX 77030, U.S.A; Centre for Cellular and Molecular Platforms, NCBS-TIFR, GKVK Post, Bellary Road, Bangalore 560065, India. Electronic address: - - 2014
Inclusion bodies (IBs) are commonly formed in E.coli during over expression of recombinant proteins in non-native state. Isolation, denaturation and refolding of these IBs is generally practiced to obtain functional protein. However, along this process IBs tend to form non-specific interactions with sheared nucleic acids from the genome, thus getting ...
Pradhan Tuhin T Department of Chemistry, Korea University, Seoul 130-701, Korea. - - 2014
In the past few decades, the development of chemosensors for neurotransmitters has emerged as a research area of significant importance, which attracted a tremendous amount of attention due to its high sensitivity and rapid response. This current review focuses on various neurotransmitter detection based on fluorescent or colorimetric spectrophotometry published ...
Napora-Wijata Kamila K ACIB GmbH, Graz, - - 2014
An increasing demand for non-petroleum-based products is envisaged in the near future. Carboxylic acids such as citric acid, succinic acid, fatty acids, and many others are available in abundance from renewable resources and they could serve as economic precursors for bio-based products such as polymers, aldehyde building blocks, and alcohols. ...
Yang Chen - - 2014
The pKa values of a series of chiral Bronsted acids, including N-triflylphosphoramides, bis(sulfonyl)imides, bis(sulfuryl)imides, dicarboxylic acids, sulfonic acids, and N-phosphinyl phosphoramides, were predicted by using the SMD/M06-2x/6-311++G(2df,2p)//B3LYP/6-31+G(d) method in DMSO. The results revealed that the calculated pKa values were from -9.06 to 12.18 for different type acids. By using the ...
Kristiana Ina I Curtin Water Quality Research Centre, Department of Chemistry, Curtin University, Kent Street, Bentley 6102, Perth, Australia. Electronic address: - - 2014
The formation of disinfection by-products (DBPs) is a public health concern due to their potential adverse health effects. Robust and sensitive methods for the analysis of DBPs, as well as appropriate sample handling procedures, are essential to obtain accurate, precise and reliable data on DBP occurrence and formation. In particular, ...
Erb William W Laboratoire de Chimie Moleculaire et Thio-organique, ENSICAEN, Universite de Caen, 6 boulevard du Marechal Juin, 14050 Caen - - 2014
An unprecedented spontaneous reactivity between diazonium salts and diboronic acid has been unveiled, leading to a versatile arylboronic acid synthesis directly from (hetero)arylamines. This fast reaction (35 min overall) tolerates a wide range of functional groups and is carried out under very mild conditions. The radical nature of the reaction mechanism ...
Guy Alexandre A Institut des Biomolécules Max Mousseron,UMR 5247 - CNRS - University Montpellier I and II - ENSCM, Faculty of Pharmacy, Montpellier (France), Fax: - - 2014
A wide variety of metabolic products of polyunsaturated fatty acids is of paramount importance for improving our medical knowledge in the field of oxidized lipids. Two novel metabolites of n-3 polyunsaturated fatty acids, 8-F3t -IsoP and 10-F4t -NeuroP as well as a deuterated derivative thereof were synthesized based on an ...
Pinheiro Vitor B VB MRC Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge, CB2 0QH, - - 2014
Nucleic acids display remarkable properties beyond information storage and propagation. The well-understood base pairing rules have enabled nucleic acids to be assembled into nanostructures of ever increasing complexity. Although nanostructures can be constructed using other building blocks, including peptides and lipids, it is the capacity to evolve that sets nucleic ...
Shimizu Tomoaki - - 2014
The aza-Clasen rearrangement of N-aryl-2-vinylazetidines has been explored. N-aryl-2-vinylazetidines were transformed to corresponding tetrahydrobenzazocines in good yields. Unexpectedly, the tetrahydrobenzazocine was unstable and readily isomerized to vinyltetrahydroquinoline in the presence of acid. The mechanism of this ring contraction was studied in detail.
Xu Ke K State Key Laboratory of Microbial Metabolism, and School of Life Sciences & Biotechnology, Shanghai Jiao Tong University, Shanghai 200240, People's Republic of - - 2014
Lactic acid is a platform chemical with various industrial applications, and its derivative, calcium lactate, is an important food additive. Fermentation coupled with in situ product removal (ISPR) can provide more outputs with high productivity. The method used in this study was based on calcium lactate crystallization. Three cycles of ...
Kintz P P X-Pertise Consulting, 84 route de Saverne, F-67205 Oberhausbergen, France. Electronic address: - - 2014
The hair of 97 cases were analysed for ethyl glucuronide (EtG) and fatty acid ethyl esters (FAEE, including ethyl myristate, ethyl palmitate, ethyl oleate and ethyl stearate) according to the Society of Hair Testing guidelines to examine the role of both tests in documenting chronic excessive alcohol drinking, particularly when ...
Carrascoza Francisco F Department of Chemistry, Faculty of Chemistry and Chemical Engineering, "Babes-Bolyai" University, 11 Arany Janos Str, Cluj-Napoca RO-400028, Romania. Electronic address: - - 2014
Potential energy surface (PES) were built for nineteen amino acids using density functional theory (PW91 and DFT M062X/6-311**). Examining the energy as a function of the φ/ψ dihedral angles in the allowed regions of the Ramachandran plot, amino acid groups that share common patterns on their PES plots and global ...
Zhang Bing B State Key Laboratory of Food Science and Technology, Nanchang University, Nanchang 330047, China; Guelph Food Research Centre, Agriculture and Agri-Food Canada, 93 Stone Road West, Guelph, ON N1G 5C9, - - 2014
Understanding the profile of lipophilic phytochemicals in lentils is necessary to better understand the health benefits of lentils. The fatty acid, carotenoid and tocopherol compositions and antioxidant activities of the lipophilic extracts of 20 lentil cultivars (10 red and 10 green) were therefore examined. Lentils contained 1.52-2.95% lipids, of which ...
Tkaczewska Joanna J Department of Animal Product Technology, Faculty of Food Technology, University of Agriculture, Krakow, - - 2014
Although environmental factors greatly affect the quality of carp meat, no regulations impose labelling the cultivation place of freshwater fish. That is why the purpose of this study was to determine the quality of carp meat cultivated in several regions of Poland as well as assess the necessity of implementing ...
Chia Xinyi X Division of Chemistry and Biological Chemistry, School of Physical and Mathematical Sciences, Nanyang Technological University, 21 Nanyang Link 637371, Singapore - - 2014
Halogenated sp(2) materials are of high interest owing to their important electronic and electrochemical properties. Although methods for graphite and graphene fluorination have been extensively researched, the fundamental electrochemical properties of fluorinated graphite are not well established. In this paper, the electrochemistry of three fluorographite materials of different carbon-to-fluorine ratio ...
Gupta Neil N Epidemic Intelligence Service, Centers for Disease Control and Prevention, Atlanta, - - 2014
Background. Compounding pharmacies often prepare parenteral nutrition (PN) and must adhere to rigorous standards to avoid contamination of the sterile preparation. In March 2011, Serratia marcescens bloodstream infections (BSIs) were identified in five patients receiving PN from a single compounding pharmacy. An investigation was conducted to identify potential sources of contamination ...
Scheler Ott O Department of Biotechnology, IMCB, University of Tartu, Riia 23, Tartu 51010, - - 2014
There is a growing need for quick and reliable methods for microorganism detection and identification worldwide. Although traditional culture-based technologies are trustworthy and accurate at a relatively low cost, they are also time- and labor-consuming and are limited to culturable bacteria. Those weaknesses have created a necessity for alternative technologies ...
Brock Nelson L NL Institut für Organische Chemie, Hagenring 30, 38106 Braunschweig, Germany. - - 2014
The biosynthesis of tropodithietic acid was investigated using a combinatorial approach of feeding experiments, gene knockouts and bioinformatic analyses. The mechanism of sulfur introduction is distinct from known mechanisms in holomycin, thiomarinol A and gliotoxin biosynthesis.
Uttaro Antonio D AD Instituto de Biología Molecular y Celular de Rosario (IBR), CONICET, Facultad de Ciencias Bioquímicas y Farmacéuticas, Universidad Nacional de Rosario, Rosario, Argentina. Electronic address: - - 2014
As components of phospholipids and glycosylphosphatidylinositol anchors, fatty acids are responsible for forming the core of biological membranes and the correct localization of proteins within membranes. They also contribute to anchoring proteins by direct acylation of specific amino acids. Fatty acids can be used as energy sources and serve as ...
Mamai W W Institut de Recherche en Sciences de la Santé, Direction Régionale de l'Ouest, 399 Avenue de la Liberté, 01 BP 545, Bobo-Dioulasso, Burkina Faso; 2Institut de Recherche pour le Développement (IRD), Unité Mixte de Recherche (UMR) IRD 224-Centre National de la Recherche Scientifique (CNRS) 5290-Université de Montpellier 1-Université de Montpellier 2 Maladies Infectieuses et Vecteurs Écologie, Génétique, Évolution et Contrôle, 911 Avenue Agropolis, BP 64501, 34394 Montpellier Cedex 5, France; 3Université Polytechnique de Bobo-Dioulasso, Bobo-Dioulasso, Burkina Faso; 4Université Pierre et Marie Curie (UPMC), UMR Institut National de la Recherche Agronomique-UPMC 1272 PISC, 7 quai St Bernard, 75252 Paris Cedex 05, France; 5Université de Rennes 1, UMR CNRS 6553 Ecosystèmes, Biodiversité, Evolution, Campus de Beaulieu, 263 Avenue du Gal Leclerc, CS 74205 35042 Rennes Cedex, - - 2014
Abstract This study explored the metabolic adjustments prompted by a switch between the rainy and dry season conditions in the African malaria mosquitoes Anopheles gambiae (M and S molecular forms) and Anopheles arabiensis. Mosquitoes were reared in contrasted experimental conditions reflecting environmental variation in Burkina Faso. Thirty-five metabolites (including sugars, ...
Chakraborty Saikat S National Centre for Biological Sciences, TIFR , GKVK Bellary Road, Bangalore, 560065 Karnataka, - - 2014
Conspectus The impact of nucleic acid nanotechnology in terms of transforming motifs from biology in synthetic and translational ways is widely appreciated. But it is also emerging that the thinking and vision behind nucleic acids as construction material has broader implications, not just in nanotechnology or even synthetic biology, but ...
Zhang Haofei H Department of Environmental Sciences and Engineering, Gillings School of Global Public Health, The University of North Carolina at Chapel Hill , Chapel Hill, North Carolina 27599, United - - 2014
Secondary organic aerosol (SOA) formation from 2-methyl-3-buten-2-ol (MBO) photooxidation has recently been observed in both field and laboratory studies. Similar to the level of isoprene, the level of MBO-derived SOA increases with elevated aerosol acidity in the absence of nitric oxide; therefore, an epoxide intermediate, (3,3-dimethyloxiran-2-yl)methanol (MBO epoxide), was synthesized ...
Laghi Luca L Centre of Foodomics, Department of Agro-Food Science and Technology, University of Bologna, Bologna, - - 2014
Bacterial vaginosis (BV) is a common vaginal disorder characterized by the decrease of lactobacilli and overgrowth of Gardnerella vaginalis and resident anaerobic vaginal bacteria. In the present work the effects of rifaximin vaginal tablets on vaginal microbiota and metabolome of women affected by BV were investigated by combining quantitative PCR ...
Matsumoto Kazushige K School of Environmental Science and Engineering, Kochi University of Technology, Miyanokuchi, Tosayamada, Kami, Koch, - - 2014
An improved method, which is highly reproducible, was developed for the enantioseparation of racemic O-ethyl phenylphosphonothioic acid () with brucine by introducing seeding to a supersaturated solution of the diastereomeric salt mixture. The present method gave both diastereomeric salts in high yields with a diastereomeric ratio of >99.5:0.5 upon choosing ...
Masiewicz Paweł P Department of Microbiology, Ludwik Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Wrocław, - - 2014
During infection of macrophages, Mycobacterium tuberculosis, the pathogen that causes tuberculosis, utilizes fatty acids as a major carbon source. However, little is known about the coordination of the central carbon metabolism of M. tuberculosis with its chromosomal replication, particularly during infection. A recently characterized transcription factor called PrpR is known ...
< 2 3 4 5 6 7 8 9 10 11 12 >