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Reboredo-Rodríguez P P Nutrition and Bromatology Group, Department of Analytical and Food Chemistry, Faculty of Food Science and Technology, University of Vigo, Ourense Campus, E-32004 Ourense, - - 2014
Systematic studies of physico-chemical and stability-related properties, and chemical composition, of extra virgin olive oils (EVOOs) obtained from drupes cropped in specific regions are of special agricultural interest. This is particularly so with new production areas, where careful selection of the most suitable olive varieties for EVOO production is required. ...
Müller Ulrich F UF Chemistry and Biochemistry, University of California San Diego, La Jolla, CA 92093 (USA). - - 2014
RNA world: The chelation of magnesium ions by citric acid prevents the magnesium-induced aggregation of lipid vesicles and RNA degradation while promoting nonenzymatic RNA oligomerization. These findings suggest a unique role for this simple organic acid in supporting key processes in RNA world organisms.
Hajra Saumen S Department of Chemistry, Indian Institute Technology Kharagpur, Kharagpur 721302, India. - - 2014
Chiral BOX-Cu(OTf)2 catalyzed enantioselective aminolactonization of the tert-butyl ester of alkenoic acids has been developed via in situ aziridination using PhINNs as the nitrene source. It provides exclusively trans-γ- and δ-amino lactones including an additional all-carbon quaternary stereo-centre with up to 98% ee in good to excellent yields.
Zhang Yinfeng Y Department of Chemistry, State Key Laboratory of Synthetic Chemistry, The University of Hong Kong, Pokfulam Rd., Hong Kong (China), Fax: - - 2014
β-Hydroxy-α-amino acids are not only used by synthetic chemists but are also found in natural products, many of which show anti-microbial or anti-cancer properties. Over the past 30 years, chemists have searched for many asymmetric routes to these useful building blocks. Initial attempts to synthesize these compounds utilized chiral auxiliaries and ...
Hermanson Daniel J DJ A.B. Hancock Jr Memorial Laboratory for Cancer Research, Departments of Biochemistry, Chemistry, and Pharmacology, Vanderbilt Institute of Chemical Biology Center in Molecular Toxicology and Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN 37232, - - 2014
Pharmacologic augmentation of endogenous cannabinoid (eCB) signaling is an emerging therapeutic approach for the treatment of a broad range of pathophysiological conditions. Thus far, pharmacological approaches have focused on inhibition of the canonical eCB inactivation pathways - fatty acid amide hydrolase (FAAH) for anandamide and monoacylglycerol lipase (MAGL) for 2-arachidonoylglycerol. ...
Poreba M M Division of Bioorganic Chemistry, Faculty of Chemistry, Wroclaw University of Technology, Wybrzeze Wyspianskiego 27, Wroclaw, - - 2014
Traditional combinatorial peptidyl substrate library approaches generally utilize natural amino acids, limiting the usefulness of this tool in generating selective substrates for proteases that share similar substrate specificity profiles. To address this limitation, we synthesized a Hybrid Combinatorial Substrate Library (HyCoSuL) with the general formula of Ac-P4-P3-P2-Asp-ACC, testing the approach ...
Adler Philipp P Institute of Biochemical Engineering, Technische Universität Braunschweig, 38106 Braunschweig, - - 2014
Acetic acid bacteria (AAB) play an important role during cocoa fermentation, as their main product acetate is a major driver for development of desired cocoa flavors. Here, we investigated the specialized metabolism of these bacteria under cocoa pulp fermentation simulating conditions. A carefully designed combination of parallel (13)C isotope experiments ...
Azzout-Marniche Dalila D AgroParisTech, UMR914 Nutrition Physiology and Ingestive Behavior, Paris, - - 2014
This review presents the different pathways by which protein and amino acid impact glucose control. The review more particularly discusses the contradictory effects reported in the literature on the involvement of amino acid on glucose production and in insulin secretion and sensitivity. Some recent findings allow a better understanding of ...
Kunacheva Chinagarn C Advanced Environmental Biotechnology Center, Nanyang Environment & Water Research Institute, Nanyang Technological University, 637141 Singapore, Singapore. Electronic address: - - 2014
Effluents from biological processes contain a wide range of complex organic compounds, including soluble microbial products (SMP) and extracellular polymers (ECP), released during bacteria metabolism in mixed culture in bioreactors. It is important to clearly identify the primary components of SMPs and ECPs in order to understand the fundamental mechanisms ...
Bredehöft Jan Hendrik JH Institute for Applied and Physical Chemistry, University of Bremen, Bremen, - - 2014
The basic units that constitute essential biopolymers (proteins and nucleic acids) are enantiomerically biased. Proteins are constructed from L-amino acids and nucleic acids possess a backbone composed exclusively of D-sugars. Photochirogenesis has been postulated to be the source of this homochirality of biomolecules: Asymmetric photochemical reactions were catalyzed by circularly ...
Jaworek K K Institute of Non-Ferrous Metals, 44-100, Gliwice, Sowinskiego 5, Poland, - - 2014
The paper presents results of the studies photodegradation, photooxidation, and oxidation of phenylarsonic acid (PAA) in aquatic solution. The water solutions, which consist of 2.7 g dm(-3) phenylarsonic acid, were subjected to advance oxidation process (AOP) in UV, UV/H2O2, UV/O3, H2O2, and O3 systems under two pH conditions. Kinetic rate constants and ...
Sachleben Joseph R JR Biomolecular NMR Core Facility, Biological Sciences Division, The University of Chicago, Chicago, IL, 60637, USA, - - 2014
Quantifying the amounts and types of lipids present in mixtures is important in fields as diverse as medicine, food science, and biochemistry. Nuclear magnetic resonance (NMR) spectroscopy can quantify the total amounts of saturated and unsaturated fatty acids in mixtures, but identifying the length of saturated fatty acid or the ...
Lin Chen-Chen CC Department of Chemistry, University of Bergen, P.O. Box 7803, NO-5020 Bergen, - - 2014
Fatty acid methyl esters from marine sources were analyzed by gas chromatography-mass spectrometry on three ionic liquid columns, SLB-IL61, SLB-IL82 and SLB-IL100 (Supelco). Retention indices (equivalent chain lengths) are reported for more than 100 compounds and the overlap patterns are evaluated from these data. The influence of chromatographic conditions on ...
Jung Cheulhee C Institute for Cellular and Molecular Biology, University of Texas at Austin , Austin, Texas 78712, United - - 2014
Conspectus While the field of DNA computing and molecular programming was engendered in large measure as a curiosity-driven exercise, it has taken on increasing importance for analytical applications. This is in large measure because of the modularity of DNA circuitry, which can serve as a programmable intermediate between inputs and ...
Vera Pingitore Esteban E Centro de Referencia para Lactobacilos CERELA-CONICET , Tucumán , Argentina - - 2014
Abstract Context: The administration of pharmabiotics is a promising alternative to antimicrobial drugs for the treatment and/or prevention of female urogenital infections. Objective: To design pharmabiotic formulations including bioactive ingredients of microbial origin combined with non-microbial substances and then to evaluate the stability of the combinations during freeze-drying and storage. ...
Dusselier Michiel M Center for Surface Chemistry and Catalysis, KU Leuven, Kasteelpark Arenberg 23, Leuven, 3000, Belgium, - - 2014
This review discusses topical chemical routes and their catalysis for the conversion of cellulose, hexoses, and smaller carbohydrates to lactic acid and other useful α-hydroxy acids. Lactic acid is a top chemical opportunity from carbohydrate biomass as it not only features tremendous potential as a chemical platform molecule; it is ...
Salomon Pierre P Laboratoire de Synthèse Organique, CNRS UMR 7652, Ecole Polytechnique , 91128 Palaiseau, Cedex, - - 2014
The preparation of O-octadecyl-S-chlorodifluoromethyl xanthate from chlorodifluoroacetic acid and its use as a convenient source of chlordifluoromethyl radicals is described. This reagent may be used to access gem-difluoroalkenes and -dienes, as well as (2,2-difluoroethyl)indolines, -indoles, and -naphthols.
Paiva Lisete L Departamento de Ciências Tecnológicas e Desenvolvimento (DCTD), Universidade dos Açores, 9501-801 Ponta Delgada, S. Miguel, Açores, Portugal; Centro de Investigação de Recursos Naturais (CIRN), Departamento de Biologia, Universidade dos Açores, 9501-801 Ponta Delgada, S. Miguel, Açores, Portugal; Centro Interdisciplinar de Investigação Marinha e Ambiental (CIIMAR/CIMAR), Universidade do Porto, Rua dos Bragas 289, 4050-123 Porto, Portugal. Electronic address: - - 2014
Fucus spiralis, Porphyra sp. and Osmundea pinnatifida are macroalgae consumed as food in some of the Azorean Islands, but little information is available on their nutritional value. This paper presents information on the nutritional aspects in terms of proteins (9.71-24.82%), lipids (5.23-8.88%), soluble carbohydrates (17.59-25.37%), ash (22.31-38.55%), minerals (0.96-1.82 for ...
Eddleston Mark D MD Department of Chemistry, University of Cambridge, Cambridge, CB2 1EW, United - - 2014
In previous studies, cocrystals have been shown to be susceptible to dissociation at high humidity because of differences in the solubilities of the two coformer molecules, especially when these molecules can form hydrates. Contrastingly, however, the propensity of the pharmaceutically active compound caffeine to hydrate formation is reduced by cocrystallization ...
Jallet V V Sorbonne Universités, UPMC Univ Paris 06, CNRS UMR 8232, Institut Parisien de Chimie Moléculaire, F-75005 Paris, France. - - 2014
Covalent amphiphilic polyoxometalates generated from alkylphosphonic acids have been synthesized, characterized and monitored by multinuclear NMR spectroscopy. Among them, K3H[γ-SiW10O36(C12H25PO)2] has been successfully used as a surfactant for the stabilization of a Winsor I type microemulsion system.
Masutomi Koji - - 2014
It has been established that a cationic Rh(I)/(S)-Segphos or (S)-DTBM-Segphos complex and benzoic acid catalyze the enantioselective cycloisomerization of 1,6-enynes, possessing carbonyl groups at the enyne linkage, to 2-alkylidenebicyclo[3.1.0]hexanes. The present cycloisomerization may involve site selective γ-hydrogen elimination. The one-pot enantioselective cycloisomerization and lactonization of 1,6-enynes, leading to bicyclic lactones, ...
Noel Amandine A Departments of Chemistry and Chemical Engineering and the Laboratory for Synthetic-Biologic Interactions, Texas A&M University , College Station, Texas 77842-3012, United - - 2014
Ferulic acid (FA), a bio-based resource found in fruits and vegetables, was coupled with a hydroxyl-amino acid to generate a new class of monomers to afford poly(carbonate-amide)s with potential to degrade into natural products. l-Serine was first selected as the hydroxyl-amino partner for FA, from which the activated p-nitrophenyl carbonate ...
Kanayama Yoshinori Y Graduate School of Agricultural Science, Tohoku University, Sendai 981-8555, Japan. Electronic address: - - 2014
The aldo-keto reductase (AKR) superfamily is a large enzyme group of NADP-dependent oxidoreductases with numerous roles in metabolism, but many members in this superfamily remain uncharacterized. Here, PpAKR1, which was cloned from the rosaceous peach tree (Prunus persica), was investigated as a member of the superfamily. While PpAKR1 had amino ...
Hsu Wen-Hung - - 2014
The acid-suppressive agents have been linked with an increased risk of infectious disease. The relationship between these drugs and Mycobacterium Tuberculosis (TB) was not been reported. We conducted a case-control study using data from National Health Insurance research database of Taiwan. From 1996 till 2008, and 6541 cases were defined ...
Ma Huan - - 2014
Novel corncob-derived solid acid catalysts were successfully synthesized for the first time by hydrothermal method. The influences of different preparation conditions were investigated, and the structure-function relationships of the resulting catalysts were also discussed based on the analysis of structure and composition. Compared to conventional solid acid catalysts, the corncob-derived ...
do Nascimento Fernando Henrique FH Instituto de Química, Universidade de São Paulo, C.P. 26077, 05513-970 São Paulo, SP, - - 2014
Geochemical mobility of Hg(II) species is strongly affected by the interactions of these compounds with naturally occurring adsorbents such as humic acids, clay minerals, oxides, etc. Interactions among these sorbents affect their affinity for Hg(II) and a full understanding of these processes is still lacking. The present work describes the ...
Wang Qiang Q Key Laboratory of Pulp & Paper Science and Technology (Qilu University of Technology), Ministry of Education, Jinan, Shandong 250353, PR China; Limerick Pulp and Paper Centre, University of New Brunswick, Fredericton, New Brunswick E3B 5A3, Canada. Electronic address: - - 2014
Lignin removal is essential for value-added utilization of hemicelluloses and acetic acid present in the prehydrolysis liquor (PHL) of a kraft-based hardwood dissolving pulp production. In this paper, a novel process concept, consisting of laccase-induced lignin polymerization, followed by filtration/flocculation, was developed to enhance the lignin removal. The results showed ...
Andre Markus M Institute of Process Engineering in Life Sciences, Section II: Technical Biology, Karlsruhe Institute of Technology, Karlsruhe, Baden-Württemberg, 76131, - - 2014
Oligopeptides are of high importance for various industrial applications, e.g. cosmetical or medical. Homooligomerizations and co-oligomerizations with anionic amino acid esters are well described but a successful synthesis of cationic heterooligopeptides has been missing so far. The present study reports the ficain-catalyzed heterooligomerizations of LysOEt with MetOEt, leading to cationic ...
Singh Purnima P School of Environment and Energy, Peking University Shenzhen Graduate School, Shenzhen, 518055, - - 2014
Thraustochytrids, a group of osmoheterotrophic marine protists, have recently gained increased attention owing to their spectacular biotechnological potentials. They possess enormous capability of producing omega-3 (ω-3) polyunsaturated fatty acids (PUFAs) such as docosahexaenoic acid (DHA), eicosapentaenoic acid (EPA), and several other bioactive metabolites, known to have nutritional implications in human ...
Bera Saurav S Medicinal and Process Chemistry Division, CSIR-Central Drug Research Institute, B.S. 10/1, Jankipuram Extension, Sitapur Road, Lucknow 226031, UP, India. gautam.panda@gmail.com - - 2014
An efficient, general and practical synthesis of diverse 3,4-dihydropyrazines, 6,7-dihydro-[1,2,3]triazolopyrazines and 7,8-dihydro-[1,2,3]triazolodiazepines through intramolecular 1,3-dipolar cycloaddition from amino acid derived common intermediates with high yields is described. Moreover, one-pot access to optically active 3-aryl substituted 6,7-dihydro-[1,2,3]triazolo[1,5-a]pyrazines in the palladium-copper co-catalytic system has also been achieved in this work. The easy ...
Ye Chao C State Key Laboratory of Food Science and Technology, Jiangnan University, 1800 Lihu Road, Wuxi, Jiangsu 214122, China; The Key Laboratory of Industrial Biotechnology, Ministry of Education, Jiangnan University, 1800 Lihu Road, Wuxi, Jiangsu 214122, - - 2014
An artificial microbial ecosystem (AME) consisting of Ketogulonicigenium vulgare and Bacillus megaterium is currently used in a two-step fermentation process for vitamin C production. In order to obtain a comprehensive understanding of the metabolic interactions between the two bacteria, a two-species stoichiometric metabolic model (iWZ-KV-663-BM-1055) consisting of 1718 genes, 1573 ...
Kishida Ryo R Department of Applied Physics, Osaka University, Suita, Osaka, - - 2014
Dopachrome conversion, where dopachrome is converted into 5,6-dihydroxyindole (DHI) or 5,6-dihydroxyindole-2-carboxylic acid (DHICA) upstream of eumelanogenesis, is a key step towards determining the DHI/DHICA monomer ratio in eumelanin, affecting the antioxidant activity. Although the formed ratio of DHI/DHICA and the conversion rate can be regulated depending on pH condition, the ...
Yuanhai Zhang Z 1Zhejiang Quhua Hospital, Quzhou, - - 2014
Hydrofluoric acid, a highly dangerous substance, can cause tissue damage and systemic toxicity by its unique mechanisms. Many cases of severe faciocervical burns due to hydrofluoric acid exposure are lethal. Herein, we present a case of 37-year-old man who suffered from hydrofluoric acid burns to his face, anterior neck, lips, ...
Liao Li-Ting LT Department of Laboratory Medicine, Wan Fang Hospital, Taipei Medical University, No. 111, Section 3, Hsing-Long Rd., Taipei 116, - - 2014
Uric acid measurement has become increasingly important, and electrochemical modified detection method based portable devices hold a dominate position in the market for point of care and self-monitoring of uric acid blood levels. However, there has been a lack of detailed performance evaluation of the electrochemical detection devices that are ...
Yokoi Toshiyuki T Chemical Resources Laboratory, Tokyo Institute of Technology, 4259 Nagatsuta, Midori-ku, Yokohama 226-8503, Japan. - - 2014
Treatment of the zeolitic layered precursor of Al-MWW, so-called Al-MWW(P), with diethoxydimethylsilane (DEDMS) in acidic media leads to the formation of an aluminosilicate-type interlayer-expanded zeolite MWW (Al-IEZ-MWW) with expanded 12-membered ring (12-MR) micropores. However, the silylation process under acidic conditions simultaneously causes dealumination from the MWW framework, resulting in a ...
Han Lianshu L Department of Pediatric Endocrinology and Genetic Metabolism, Xinhua Hospital, Shanghai Institute for Pediatric Research, Shanghai Jiaotong University School of Medicine, Shanghai, - - 2014
Information concerning inherited metabolic diseases in China is scarce. We investigated the prevalence and age distributions of amino acid, organic acid, and fatty acid oxidation disorders in Chinese patients. Blood levels of amino acids and acylcarnitines (tandem mass spectrometry) were measured in 18,303 patients with suspected inherited metabolic diseases. Diagnosis ...
Grijalvo Santiago S Institute for Advanced Chemistry of Catalonia (IQAC-CSIC), and Networking Research Centre of Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN), Department of Chemical and Biomolecular Nanotechnology , Jordi Girona 18-26, 08034 Barcelona , Spain +34 934006145 ; +34 932045904 ; - - 2014
Introduction: The use of aptamers, antisense technology and RNA interference has allowed nucleic acids to be considered as promising alternatives to classical drugs. However, nucleic acids face several obstacles in the creation of effective nucleic acid drugs. The development of these approaches has strengthened the pipeline with an increasing number ...
Mustafa Hussein H HH School of Chemistry, Bangor University, Bangor, Gwynedd, LL57 - - 2014
Ozonolysis of Z,Z,Z-cylonona-1,4,7-triene leads to a 1,9-difunctionalised Z,Z-3,6-nonadiene which is readily converted into a range of polyunsaturated pheromones and fatty acids.
Kesebir Sermin S Erenköy Psychiatry Education and Research Hospital, Istanbul, - - 2014
The aim of this study was to investigate whether uric acid levels are different between patients with remission period of bipolar disorder type I (BD) and patients with remission period of major depressive disorder (MDD). For this aim 41 patients diagnosed with BD and 30 patients diagnosed with recurrent MDD ...
Huerlimann Roger R School of Marine and Tropical Biology, James Cook University, Townsville 4811, Australia; Centre for Sustainable Tropical Fisheries and Aquaculture, Townsville 4811, Australia; James Cook University, Comparative Genomics Centre, Townsville, Queensland 4811, - - 2014
Very long-chain polyunsaturated fatty acids (VLC-PUFAs) are important dietary requirements for maintaining human health. Many marine microalgae are naturally high in ω-3 VLC-PUFAs, however, the molecular mechanisms underpinning fatty acid (FA) desaturation and elongation in algae are poorly understood. An advanced molecular understanding would facilitate improvements of this nascent industry. ...
Liu Bingjie B College of Chemistry and Molecular Engineering, Zhengzhou University, Zhengzhou, Henan Province 450001, China. changjunbiao@zzu.edu.cn - - 2014
A straightforward and efficient copper(i)/amino acid-catalyzed intramolecular Ullmann-type C-O coupling reaction has been developed. This protocol affords a facile methodology for the synthesis of a series of novel 2,4,5-substituted oxazoles from readily accessible N-acyl-2-bromo enamides under mild conditions.
Liu Ming - - 2014
Imine cage molecules can be reduced to amines to improve their chemical stability, but this introduces molecular flexibility. Hence, amine cages tend not to exhibit permanent, solid-state porosity. We report a synthetic strategy to achieve shape per-sistence in amine cages by tying the cage vertices with carbonyls such as formaldehyde. ...
Fonseca-Madrigal Jorge J Universidad Michoacana de San Nicolas de Hidalgo, - - 2014
Currently existing data show that the capability for long-chain polyunsaturated fatty acids (LC-PUFA) biosynthesis in teleost fish is more diverse than in other vertebrates. Such diversity has been primarily linked to the subfunctionalization that teleostei Fads2 desaturases have undergone during evolution. We previously showed that Chirostoma estor, one of the ...
Tang Zhenchen Z State Key Laboratory of Physical Chemistry of Solid Surfaces, Collaborative Innovation Center of Chemistry for Energy Materials, National Engineering Laboratory for Green Chemical Productions of Alcohols, Ethers and Esters, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen 361005 (PR - - 2014
The transformation of cellulose or cellulose-derived carbohydrates into platform chemicals is the key to establish biomass-based sustainable chemical processes. The systems able to catalyze the conversion of cellulose into key chemicals in water without the consumption of hydrogen are limited. We report that simple vanadyl (VO(2+) ) cations catalyze the ...
Vecino X X Chemical Engineering Department, School of Industrial Engineering (EEI), University of Vigo., Campus As Lagoas-Marcosende., 36310, Vigo-Pontevedra, - - 2014
There is currently much interest in the use of natural biosurfactants and bioemulsifiers, mainly in the cosmetic, pharmaceutical and food industries. However, there are no studies about the optimization of the extraction conditions of cell bound biosurfactants. In this work, a biosurfactant with emulsifier properties was extracted from L. pentosus ...
Procentese Alessandra A Dipartimento di Ingegneria Chimica, dei Materiali e della Produzione Industriale, Università degli Studi di Napoli Federico II, P.le V. Tecchio 80, 80125 Napoli, - - 2014
The paper reports the assessment of the growth kinetics of Clostridium acetobutylicum DSM 792 adopting xylose as carbon source. Xylose is the fundamental component of hemicellulose hydrolysis, a relevant fraction of lignocellulosic feedstocks for biofuel production. Tests were carried out in a CSTR operated under controlled pH. The effects of ...
Gao Bifen - - 2014
Anatase TiO2 microspheres with a high percentage of exposed (001) facets were synthesized by a template-free hydrothermal method without using concentrated hydrofluoric acid. The influence of various experiment conditions, such as hydrothermal temperature, acid condition, reaction time, etc., on the morphology of the final products was investigated in detail. The ...
Budak Nilgün H NH Dept. of Food Technology, Egirdir Vocational School, Süleyman Demirel Univ., Isparta, - - 2014
A variety of natural vinegar products are found in civilizations around the world. A review of research on these fermented products indicates numerous reports of health benefits derived by consumption of vinegar components. Therapeutic effects of vinegar arising from consuming the inherent bioactive components including acetic acid, gallic acid, catechin, ...
Weaver Karen - - 2014
Lipid is an essential macronutrient in parenteral nutrition (PN) support. intravenous (IV) lipid provides essential fatty acids and a concentrated calorie source. Preterm infants are at risk for essential fatty deficiency early in life. Lipid administration is associated with some risks, and there are guidelines for administration to minimize complications. ...
- - 2014
A short-cut review was carried out to establish whether topical tranexamic acid can be used to treat spontaneous epistaxis. Thirty-three papers were found, of which two presented the best evidence to answer the clinical question. The author, date and country of publication, patient group studied, study type, relevant outcomes, results ...
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