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Gavara Raquel - - 2014
In the frame of the metamorphosis chemistry, where complexity is achieved at the bottom, a multistate system based on 4'-carboxy-7-hydroxyflavylium is described. Twelve species reversibly interconverted by pH and light stimuli were identified at the equilibrium or as transients. The carboxylic substituent deprotonates at moderately acidic pH values and by ...
Thompson R Adam RA Bredesen Center for Interdisciplinary Research and Graduate Education, The University of Tennessee, Knoxville, TN, - - 2014
Biodiesels in the form of fatty acyl ethyl esters (FAEEs) are a promising next generation biofuel due to their chemical properties and compatibility with existing infrastructure. It has recently been shown that expression of a bacterial acyl-transferase in the established industrial workhorse Saccharomyces cerevisiae can lead to production of FAEEs ...
Castañeda-Arriaga Romina - - 2014
The free radical scavenging activity of lipoic acid (LA) and dihydrolipoic acid (DHLA) has been studied in non-polar and aqueous solutions, using the Density Functional Theory and several oxygen centered radicals. It was found that lipoic acid is capable of scavenging only very reactive radicals, while the dehydrated form is ...
Bullwinkle Tammy T Department of Microbiology , Ohio State University , Columbus , United - - 2014
Aminoacyl-tRNA synthetases use a variety of mechanisms to ensure fidelity of the genetic code and ultimately select the correct amino acids to be used in protein synthesis. The physiological necessity of these quality control mechanisms in different environments remains unclear, as the cost versus benefit of accurate protein synthesis is ...
Castro-Gómez Pilar P Department of Bioactivity and Food Analysis, Lipid Group, Institute of Food Science Research (CIAL), CSIC-UAM, Autónoma University of Madrid, Nicolás Cabrera, 9, 28049, Madrid, - - 2014
Isolation is the main bottleneck in the analysis of fatty acids in biological samples and foods. In the last few decades some methods described direct derivatization procedures bypassing these steps. They involve the utilization of methanolic HCL or BF3 as catalysts, but several evidences from previous works suggest these reagents ...
Martin Camilia R CR NICU, Department of Neonatology, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Avenue, Rose-318, Boston, MA 02215, USA; Division of Translational Research, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Avenue, Boston, MA 02215, USA. Electronic address: - - 2014
Challenges remain in optimizing the delivery of fatty acids to attain their nutritional and therapeutic benefits in neonatal health. In this review, knowledge about placental transfer of fatty acids to the developing fetus is summarized, the potential role and mechanisms of fatty acids in enhancing neonatal health and minimizing morbidities ...
Bayes Stephen K SK Department of Environmental Science, Policy and Management, University of California, Berkeley, CA, 94720-3114, USA, - - 2014
Tracking the movement of small organisms is of tremendous importance to understanding the ecology of populations, communities, and ecosystems. However, it remains one of the most difficult challenges facing the field of movement ecology. We developed an intrinsic marking technique for tracking small organisms using dietary fatty acid profiles as ...
Meijer Alfred J AJ Department of Medical Biochemistry, Academic Medical Center, University of Amsterdam, Meibergdreef 15, 1105 AZ, Amsterdam, The Netherlands, - - 2014
Amino acids not only participate in intermediary metabolism but also stimulate insulin-mechanistic target of rapamycin (MTOR)-mediated signal transduction which controls the major metabolic pathways. Among these is the pathway of autophagy which takes care of the degradation of long-lived proteins and of the elimination of damaged or functionally redundant organelles. ...
Kaluzny L L Department of Pediatric Gastroenterology and Metabolism, I Chair of Pediatrics, Poznan University of Medical Sciences, Szpitalna, Poznan, Poland. - - 2014
Parenteral nutrition is now a standard part of supportive treatment in pediatric departments. We describe four cases in which parenteral nutrition was extremely difficult due to coincidence with inborn errors of metabolism. The first two cases was fatty acid beta-oxidation disorders associated with necrotizing enterocolitis and congenital heart disease. Thus, ...
Mathias Rasika A RA Division of Allergy and Clinical Immunology, Department of Medicine, The Johns Hopkins University, Baltimore, MD 21224, - - 2014
Unequivocally, genetic variants within the fatty acid desaturase (FADS) cluster are determinants of long chain polyunsaturated fatty acid (LC-PUFA) levels in circulation, cells and tissues. A recent series of papers have addressed these associations in the context of ancestry; evidence clearly supports that the associations are robust to ethnicity. However ...
Lau Danny C P - - 2014
Dystrophic lakes are widespread in temperate regions and intimately interact with surrounding terrestrial ecosystems in energy and nutrient dynamics, yet the relative importance of autochthonous and allochthonous resources to consumer production in dystrophic lakes remains controversial. We argue that allochthonous organic matter quantitatively dominates over photosynthetic autotrophs in dystrophic lakes, ...
Etto Rafael Mazer RM Department of Chemistry, Universidade Estadual de Ponta Grossa, CEP 84030-900, Ponta Grossa, Paraná, Brazil. Electronic address: - - 2014
The acidic peatlands of southern Brazil are essential for maintenance of the Atlantic Rain Forest, one of the 25 hot-spots of biodiversity in the world. While these ecosystems are closely linked to conservation issues, their microbial community ecology and composition remain unknown. In this work, histosol samples were collected from ...
Ralla Bernhard B Department of Urology, Charité - Universitätsmedizin Berlin , Berlin , Germany - - 2014
Abstract This review focuses on the promising potential of nucleic acids in body fluids such as blood and urine as diagnostic, prognostic, predictive and monitoring biomarkers in urologic malignancies. The tremendous progress in the basic knowledge of molecular processes in cancer, as shown in the companion review on nucleic acid-based ...
Monaco Mattia Riccardo MR Max-Planck-Institut für Kohlenforschung, Kaiser-Wilhelm-Platz 1, 45470 Mülheim an der Ruhr - - 2014
Organocatalysis, catalysis using small organic molecules, has recently evolved into a general approach for asymmetric synthesis, complementing both metal catalysis and biocatalysis.1 Its success relies to a large extent upon the introduction of novel and generic activation modes.2 Remarkably though, while carboxylic acids have been used as catalyst directing groups ...
Fan Chenguang C Department of Molecular Biophysics and Biochemistry, Yale University, 266 Whitney Avenue, New Haven, CT 06520 - - 2014
We tested the substrate range of four wild-type E. coli aminoacyl-tRNA synthetases (AARSs) with a library of nonstandard amino acids (nsAAs). Although these AARSs could discriminate efficiently against the other canonical amino acids, they were able to use many nsAAs as substrates. Our results also show that E. coli tryptophanyl-tRNA ...
Kukkonen Anna Kaarina AK The Skin and Allergy Hospital, University of Helsinki - - 2014
Turnip rapeseed oil-rich in essential fatty acids and vitamin E- is a significant source of vegetable oils in the diet. Its fatty acid composition is ideal, and in addition to its current use in baby foods and margarines, components of turnip rapeseed may be increasingly used in the future. The ...
Vecino Xanel - - 2014
Corn steep liquor (CSL) is a liquid by-product generated by the corn wet-milling industry. This agro-industrial residue is obtained when corn is digested with warm water and SO2 in the presence of different spontaneously growing microorganisms. The microbial population of CSL includes lactic acid bacteria, which are widely known to ...
Sugimoto Osamu O Laboratory of Organic Chemistry, School of Food and Nutritional Sciences, University of Shizuoka, 52-1 Yada, Suruga-ku, Shizuoka 422-8526, Japan. - - 2014
The reaction of carboxylic acids with Mitsunobu reagents, prepared by the reaction of triphenylphosphine with dialkyl azodicarboxylates, followed by heating at 180-190 °C under solvent-free conditions, afforded 3-alkyl-5-aryl-1,3,4-oxadiazol-2(3H)-ones. This facile and convenient method readily provides the 1,3,4-oxadiazolone ring systems in good yields using a one-pot protocol starting from the corresponding ...
Zhuang Minyang M Beijing National Laboratory for Molecular Sciences, CAS Key Laboratory of Molecular Recognition and Function, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China. - - 2014
This paper describes an enantioselective intermolecular allylic amination catalyzed by a chiral Brønsted acid via a possible chiral contact ion pair intermediate. A variety of symmetrical or unsymmetrical allylic alcohols can be smoothly aminated to afford the desired products in moderate to high yields with good enantioselectivities and/or regioselectivities.
Song W W Department of Physics, Technische Universität München, James-Franck-Str. 1, 85748 Garching, Germany. - - 2014
A direct calorimetric measurement of the overall enthalpy change associated with self-assembly of organic monolayers at the liquid-solid interface is for most systems of interest practically impossible. In previous work we proposed an adapted Born-Haber cycle for an indirect assessment of the overall enthalpy change by using terephthalic acid monolayers ...
Akhatou Ikram - - 2014
Three strawberry varieties cultivated in soilless systems were studied for their content of primary and secondary metabolites in relation to harvest time and crop conditions. The three varieties were chosen based on their sensitivity level to environmental stress: Palomar (very sensitive), Festival (sensitive) and Camarosa (resistant). Throughout the campaign, three ...
Canas Sara S Instituto Nacional de Investigação Agrária e Veterinária, INIAV-Dois Portos, Quinta da Almoinha, 2565-191, Dois Portos, Portugal; ICAAM - Instituto de Ciências Agrárias e Ambientais Mediterrânicas, Universidade de Évora, - - 2014
Graft incompatibility of Vitis spp is an unresolved worldwide problem with important economic consequences. Grafting comprises a complex set of morphological and physiological alterations, in which the phenolic compounds seem to be strongly involved. Therefore, a detailed analysis and recognition of structural phenolic compounds diversity in the two partners of ...
Morrill Louis C LC EastCHEM, School of Chemistry, University of St Andrews, North Haugh, St Andrews, Fife, UKKY16 9ST. - - 2014
This tutorial review highlights the organocatalytic Lewis base functionalisation of carboxylic acids, esters and anhydrides via C1-ammonium/azolium enolates. The generation and synthetic utility of these powerful intermediates is highlighted through their application in various methodologies including aldol-lactonisations, Michael-lactonisations/lactamisations and [2,3]-rearrangements.
Bellavinha Karime Resende KR Departamento de Farmácia - - 2014
Abstract The aqueous solubility and drug product dissolution are important factors that determine the rate and extent of drug absorption from immediate release solid oral dosage forms. The aim of this article was to perform a folic acid biopharmaceutical study to evaluate the biowaiver of new products containing folic acid. ...
Kim Jae Yul JY School of Energy and Chemical Engineering, Ulsan National Institute of Science and Technology (UNIST) , 50 UNIST-gil, Ulsan 689-798, Republic of - - 2014
A convenient method has been discovered to incorporate Ti atoms isomorphically into a SBA-15 lattice without Ti loss. By hydrolysis of a Ti precursor near neutral pH instead of conventional acidic conditions, Ti loss was almost eliminated and its segregation to form TiO2 particles was suppressed while the mesoporous structure ...
Slattery Eoin E Department of Medicine, Division of Preventive Medicine and Nutrition, Columbia University Medical Center-New York Presbyterian Hospital, New York, New York - - 2014
Parenteral nutrition (PN) provides a means of nourishment for patients in whom oral or enteral nutrition is not possible or practical. Initial formulations consisted of carbohydrates (dextrose), amino acids, vitamins, trace minerals, electrolytes, and water. A stable intravenous fat emulsion (IVFE) permitted the combination of all 3 macronutrients in the ...
Sorribes Iván I Leibniz-Institut für Katalyse e. V. an der Universität Rostock, Albert Einstein Str. 29a, 18059 Rostock (Germany), Fax: - - 2014
A general catalytic protocol for the methylation of amines has been developed applying, for the first time, formic acid as the C1 building block and silanes as reducing agents. A broad range of aromatic and aliphatic, both primary and secondary, amines has been converted to the corresponding tertiary amines including ...
von Schacky Clemens C Medizinische Klinik I, Department Preventive Cardiology, Ludwig-Maximilians-University, Ziemssenstrasse 1, D-80336 Munich, Germany; Omegametrix, Am Klopferspitz 19, 82152 Martinsried, Germany(1). Electronic address: - - 2014
In cardiology, results of recent large intervention trials with eicosapentaenoic acid (EPA) plus docosahexaenoic acid (DHA) supplements were neutral. In contrast, in epidemiologic studies, an inverse relation between clinical events and intake of EPA+DHA was found which was steeper for higher levels of EPA+DHA. A standardized way of determining levels ...
Chatterjee Abhishek A Department of Chemistry and the Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037 (USA); Department of Chemistry, Boston College, 2609 Beacon Street, Chestnut Hill, MA 02467 - - 2014
The addition of noncanonical amino acids to the genetic code requires unique codons not assigned to the 20 canonical amino acids. Among the 64 triplet codons, only the three nonsense "stop" codons have been used to encode non-native amino acids. Use of quadruplet "frame-shift" suppressor codons provides an abundant alternative ...
Costantini Lara L Department of Ecological and Biological Sciences (DEB), Tuscia University, Largo dell'Università snc, 01100 Viterbo, Italy. Electronic address: - - 2014
In this study, chia seed flour, which is rich in omega-3 alpha-linolenic acid, and common and tartary buckwheat flour, which has a high antioxidant activity, were integrated into different types of bread with the aim of improving their nutritional value and healthy features. Our results indicate that bread made with ...
Zhang XiQing X Key Laboratory of Industrial Fermentation Microbiology, Ministry of Education, College of Biotechnology, Tianjin University of Science and Technology, Tianjin, People's Republic of - - 2014
Phenyl lactic acid (PLA) has been widely reported as a novel natural antimicrobial compound. In this study, 120 Lactobacillus plantarum were demonstrated to produce PLA by HPLC. L. plantarum IMAU10124 was screened with its PLA yield 0.229 g/l. Compared to all previous reports, it is the highest PLA-producing lactic acid ...
Fiume Monice M MM Cosmetic Ingredient Review Senior Scientific Analyst/Writer, Washington, DC, - - 2014
The CIR Expert Panel (Panel) assessed the safety of citric acid, 12 inorganic citrate salts, and 20 alkyl citrate esters as used in cosmetics, concluding that these ingredients are safe in the present practices of use and concentration. Citric acid is reported to function as a pH adjuster, chelating agent, ...
Blaul Birgit B University of Regensburg, Institute of Zoology, Universitätsstraße 31, 93053 Regensburg, Germany. Electronic address: - - 2014
Linoleic acid (C18:2(Δ9,12), LA) is crucial for many cell functions in organisms. It has long been a paradigm that animals are unable to synthesize LA from oleic acid (C18:1(Δ9), OA) because they were thought to miss Δ12-desaturases for inserting a double bound at the Δ(12)-position. Today it is clear that ...
Veillette M M Department of Chemical Engineering and Biotechnological Engineering, Engineering Faculty, Université de Sherbrooke, 2500 boulevard de l'Université, Sherbrooke, QC, Canada, J1K - - 2014
A new process was tested in order to produce and purify biodiesel from microalgae lipids and to recover unsaponifiable (added-value) lipids. This process is a two-step biodiesel production including a saponification reaction step followed by an esterification reaction step. The process includes a recovery of the unsaponified lipids between both ...
Hu Xiangang - - 2014
Graphene-related research has intensified rapidly in a wide range of disciplines, but few studies have examined ecosystem risks, particularly phytotoxicity. This study revealed that graphene significantly inhibits the number of wheat roots and the biosynthesis of chlorophyll, and altered the morphology of shoots. Humic acid (HA), a ubiquitous form of ...
Wang Zhanyun Z Institute for Chemical and Bioengineering, ETH Zurich, Wolfgang-Pauli-Strasse 10, CH-8093 Zürich, - - 2014
We identify eleven emission sources of perfluoroalkyl carboxylic acids (PFCAs) that have not been discussed in the past. These sources can be divided into three groups: [i] PFCAs released as ingredients or impurities, e.g., historical and current use of perfluorobutanoic acid (PFBA), perfluorohexanoic acid (PFHxA) and their derivatives; [ii] PFCAs ...
Ishidoh Kei-Ichi KI International Center for Biotechnology, Osaka University, 2-1 Yamadaoka, Suita, Osaka, 565-0871, - - 2014
Only limited studies are available on the molecular-level biosynthesis of cyclic lipopeptides (cyclic and hybrid molecules consisting of peptide and fatty acid moieties) in filamentous fungi. Here, we identified and characterized biosynthetic genes of the cyclic lipopeptides, known as verlamelins. Only four genes, coding for non-ribosomal peptide synthetase (NRPS), fatty ...
Laitinen Riikka - - 2014
Co-amorphous drug mixtures with low molecular weight excipients have recently been shown to be a promising approach for stabilization of amorphous drugs and thus an alternative to the traditional amorphous solid dispersion approach using polymers. However, the previous studies are limited to a few drugs and amino acids. To facilitate ...
de Oliveira Clayton R CR Federal University of São Carlos, Department of Chemistry, Rodovia Washington Luís km 235, 13565-905 São Carlos, SP, Brazil. Electronic address: - - 2014
Brazil is currently the largest exporter of concentrated orange juice and, unlike the other exporter countries, the domestic consumption is mainly based on the fresh orange juice. The quality control by evaluating the major chemical constituents under the influence of the most important factors, such as temperature and storage time ...
Del Mónaco Silvana M SM Grupo de Enología, Instituto Multidisciplinario de Investigación y Desarrollo de la Patagonia Norte (IDEPA), Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Universidad Nacional del Comahue (UNCo), Facultad de Ingeniería, Buenos Aires 1400, 8300, Neuquén, Provincia del Neuquén, - - 2014
The purpose of this study was to select autochthonous yeasts with metabolic ability to degrade L-malic acid for its potential use in young wine deacidification. 57 Patagonian non-Saccharomyces yeast of oenological origin were identified by conventional molecular methods and tested in their capability to grow at the expense of L-malic ...
Gu Liuqun L Institute of Bioengineering and Nanotechnology, 31 Biopolis Way, The Nanos, Singapore 138669. gulq@imre.a-star.edu.sg - - 2014
For efficient direct amide condensations, a new class of catalysts are developed by immobilizing boronic acids on mesocellular siliceous foam. Associated with their large pores, the microenvironments surrounding the immobilized active species greatly influence the catalytic activity. The fluoroalkyl moieties on the silica surface significantly enhance the catalytic performance along ...
Stairs Courtney W CW Centre for Comparative Genomics and Evolutionary Bioinformatics, Dalhousie University, Halifax, NS B3H 4R2, Canada; Department of Biochemistry and Molecular Biology, Dalhousie University, Halifax, NS B3H 4R2, - - 2014
Many microbial eukaryotes have evolved anaerobic alternatives to mitochondria known as mitochondrion-related organelles (MROs). Yet, only a few of these have been experimentally investigated. Here we report an RNA-seq-based reconstruction of the MRO proteome of Pygsuia biforma, an anaerobic representative of an unexplored deep-branching eukaryotic lineage. Pygsuia's MRO has a ...
Salas Joaquín J JJ Instituto de la Grasa, Av. Padre García Tejero, 4, 41012 Sevilla, Spain. Electronic address: - - 2014
Fats based on stearic acid could be a healthier alternative to existing oils especially hydrogenated fractions of oils or palm, but only a few non-tropical species produce oils with these characteristics. In this regard, newly developed high stearic oil seed crops could be a future source of fats and hard ...
Mun Sungyong S Department of Chemical Engineering, Hanyang University, Seoul 133-791, South Korea. Electronic address: - - 2014
The performance of a three-zone simulated moving bed (SMB) chromatographic process for separation of succinic acid and lactic acid has been improved to a certain extent in previous researches by applying either a partial-feeding (PF) or a port-location rearrangement (PR) to its operation. To make a further improvement, the strategy ...
Bonella Sara - - 2014
In spite of its relevant biological role, no general consensus exists on the quantitative characterisation of amino acid's hydropathy. In particular, many hydrophobicity scales exist, often producing quite different rankings for the amino acids. To make progress towards a systematic classification, we analyze amino acids' hydropathy based on the orientation ...
Haljasorg Tõiv - - 2014
Wide range of anthropogenic pollutants that possess serious environmental and health risks are known. One type of those harmful substances, that have become to the focus of interest during last decade are perfluoroalkyl acids (PFAA), which are extensively used in industry for different purposes. Due to the harmful effects that ...
Macchione Giuseppe G Glycosystems Laboratory, Instituto de Investigaciones Químicas (IIQ), Centro de Investigaciones Científicas Isla de La Cartuja, CSIC and Universidad de Sevilla, Americo Vespucio, 49, 41092 Sevilla, - - 2014
The synthesis of hyaluronic acid oligomers (tri- and tetrasaccharide) is described. We have followed a pre-glycosylation oxidation strategy. Glucuronic acid units were directly employed in coupling reactions with suitably protected glucosamine derivatives. In order to simplify the purification of synthetic intermediates, a fluorous-assisted strategy has been also explored. Using this ...
Xi Wanpeng W College of Horticulture and Landscape Architecture, Southwest University, Chongqing 400716, PR China; Agricultural College, Shihezi University, Shihezi, Xin Jiang 832003, PR China; Key Laboratory of Horticulture Science for Southern Mountainous Regions, Ministry of Education, Chongqing 400715, PR China. Electronic address: - - 2014
In this study we assessed the impact of carbon dioxide enrichment (CDE) on flavour quality development of peach fruit, using peach trees grown in a greenhouse with a carbon-dioxide-enriched atmosphere. Fruit sugar, organic acids, volatiles contents and consumer acceptability were investigated, focusing on the period of postharvest ripening. Higher levels ...
Reboredo-Rodríguez P P Nutrition and Bromatology Group, Department of Analytical and Food Chemistry, Faculty of Food Science and Technology, University of Vigo, Ourense Campus, E-32004 Ourense, - - 2014
Systematic studies of physico-chemical and stability-related properties, and chemical composition, of extra virgin olive oils (EVOOs) obtained from drupes cropped in specific regions are of special agricultural interest. This is particularly so with new production areas, where careful selection of the most suitable olive varieties for EVOO production is required. ...
Müller Ulrich F UF Chemistry and Biochemistry, University of California San Diego, La Jolla, CA 92093 (USA). - - 2014
RNA world: The chelation of magnesium ions by citric acid prevents the magnesium-induced aggregation of lipid vesicles and RNA degradation while promoting nonenzymatic RNA oligomerization. These findings suggest a unique role for this simple organic acid in supporting key processes in RNA world organisms.
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