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Han Junbin J Department of Chemistry, University of Louisville , Louisville, Kentucky 40292, United - - 2014
Brønsted or Lewis acid assisted activation of an imidogold precatalyst (L-Au-Pht, Pht = phthalimide) offers a superior way to generate cationic gold compared with the commonly used silver-based system. It is also broadly applicable for most common gold-catalyzed reactions. For reactions that require milder conditions, milder acids can be used ...
Bhattacherjee Abhishek A a Department of Botany , Presidency University , 86/1, College Street, Kolkata 700 073 , West Bengal - - 2014
Alternanthera philoxeroides (Mart.) is a tropical weed commonly known as alligator weed. It grows rapidly within a small span of time and easily available all over the world. The objective of this work was to isolate and characterise the major phenolic components present in the methanol-soluble fraction (fraction X) of ...
Boto-Ordóñez María M Biomarkers and Nutritional & Food Metabolomics Research Group, Nutrition and Food Science Department, XaRTA, INSA, Pharmacy Faculty, University of Barcelona, Avenida Joan XXIII s/n, 08028 Barcelona, Spain. - - 2014
The health benefits associated with the consumption of polyphenol-rich foods have been studied in depth, however, the full mechanism of action remains unknown. One of the proposed mechanisms is through microbiota interaction. In the present study, we aimed to explore the relationship between changes in fecal microbiota and changes in ...
Laidlaw Maggie - - 2014
Omega-3 fatty acids confer beneficial health effects, but North Americans are lacking in their dietary omega-3-rich intake. Supplementation is an alternative to consumption of fish; however, not all omega-3 products are created equal. The trial objective was to compare the increases in blood levels of omega-3 fatty acids after consumption ...
Colombo Stefano S University of Copenhagen, Department of Pharmacy, Faculty of Health and Medical Sciences , Universitetsparken 2, Copenhagen, 2100-DK , Denmark +45 35 33 64 02 ; - - 2014
Introduction: Nucleic acids have witnessed a dramatic acceleration in their therapeutic exploitation and currently represent a growing number of applications in drug development pipelines. However, a more wide-spread development of therapeutics based on nucleic acids is restricted by their poor chemical and enzymatic stability in vivo, lack of cellular uptake ...
Kula Józef J Institute of General Food Chemistry, Lodz University of Technology, Lodz 90-924, Poland. Electronic address: - - 2014
(R)-Ricinoleic acid methyl ester obtained from commercial castor oil was transformed in a three-step procedure into its S-enantiomer in overall 36% yield using ionic liquid (1-butyl-3-methylimidazolium acetate) in the key step process. The developed procedure provides easy access to (S)-ricinoleic acid and its methyl ester of over 95% enantiomeric excess. ...
Schneider Manuella M Industrial Chemistry Course, Universidade de Santa Cruz do Sul, Santa Cruz do Sul, Brasil - - 2014
In this study, we propose the use of tung cake for the production of organic acids, with an emphasis on citric acid by solid-state fermentation. We evaluated the conditions of production and the by-products from the biodiesel chain as raw materials involved in this bioprocess. First, we standardized the conditions ...
De Roo Jonathan - - 2014
We synthesized HfO2 nanocrystals from HfCl4 using a surfactant-free solvothermal process in benzylalcohol and found that the resulting nanocrystals could be transferred to nonpolar media using a mixture of carboxylic acids and amines. Using solution 1H NMR and elemental analysis, we studied the details of the transfer reaction and the ...
Nosova Emily V EV Department of Surgery, University of California, San Francisco, San Francisco, Calif; VIPERx Laboratory, San Francisco, - - 2014
Despite available medical therapies, patients with peripheral arterial disease (PAD) remain at high risk for cardiovascular events. The n-3 polyunsaturated fatty acids (PUFA), derived from marine sources, have been shown to improve cardiovascular mortality. The Omega-3 Index (O3I), a proportion of the n-3 PUFA eicosapentaenoic acid and docosahexaenoic acid in ...
Lesma G G a Dipartimento di Chimica , Università degli Studi di Milano , via C. Golgi 19, 20133 Milano , - - 2014
Within a project aimed to reintroduce non-drug hemp cultivars in the Italian Po valley, for fibre but also high added-value nutraceutical production, investigation on locally grown plants has been performed, in order to assess their oil and metabolic content. This study provides useful information regarding three different hemp cultivars, from ...
Labrenz Steven R SR Parenterals and Liquids, Drug Product Development, PDMS, Janssen R&D LLC, Malvern, Pennsylvania, - - 2014
An observation of visible particulate matter was made during formulation development of a mAb and investigations initiated to understand the colloidal instability of the formulation. It was observed that there was a loss of polysorbate in the IgG formulation and concurrent hydrolysis of polysorbate 80 (PS80) into fatty acid, polyethylene ...
Dhamankar Himanshu H Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139; Synthetic Biology Engineering Research Center (SynBERC), Massachusetts Institute of Technology, Cambridge, MA - - 2014
3-hydroxy-γ-butyrolactone (3HBL) is a versatile chiral synthon, deemed a top value-added chemical from biomass by the DOE. We recently reported the first biosynthetic pathway towards 3HBL and its hydrolyzed form, 3,4-dihydroxybutyric acid (3,4-DHBA) in recombinant Escherichia coli using glucose and glycolic acid as feedstocks and briefly described their synthesis solely ...
Hammami Hossein - - 2014
The photodecomposition of herbicides can be affectedvia adding vegetable oils to spray tank. Nine vegetable oils were compared to assess the photodecomposition of sethoxydim under natural light conditions. The experiment was conducted as completely randomized factorial design with three replications at the College of Agriculture, Ferdowsi University of Mashhad, Iran, ...
Kaura Mamta - - 2014
Conformationally restricted nucleotides such as locked nucleic acids (LNAs) are very popular as affinity-, specificity- and stability-enhancing modifications in oligonucleotide chemistry to produce probes for nucleic acid targeting applications in molecular biology, biotechnology and medicinal chemistry. Considerable efforts have been devoted in recent years to optimize LNA's biophysical properties through ...
Cvetesic Nevena N Department of Chemistry, Faculty of Science University of Zagreb, Zagreb, - - 2014
The fidelity of protein synthesis depends on the capacity of aminoacyl-tRNA synthetases (AARSs) to couple only cognate amino acid-tRNA pairs. If amino acid selectivity is compromised, fidelity can be ensured by an inherent AARS editing activity that hydrolyses mischarged tRNAs. Here, we show that the editing activity of Escherichia coli ...
Maria Daglia - - 2014
Gallic acid (3,4,5-trihydroxybenzoic acid) is a phenolic acid widely distributed in many different families of higher plants, both in free state, and as a part of more complex molecules, such as ester derivatives or polymers. In nature, gallic acid and its derivatives are present in nearly every part of the ...
Fan Gang G College of Ethnic Medicine, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, - - 2014
Swertia mussotii Franch. and Swertia chirayita Buch.-Ham. have been commonly used under the same name "Zangyinchen" for the treatment of liver and gallbladder diseases in traditional Tibetan medicine. Detailed characterization and comparison of the complete set of metabolites of these two species are critical for their objective identification and quality ...
Lin Keying K State Key Laboratory Cultivation Base of Natural Gas Conversion, College of Chemistry, Ningxia University, Yinchuan 750021, - - 2014
Liquid sulphuric acid is adopted and compared with carbon-based sulfonated solid acids (coal tar-based and active carbon-based) for furfural residues conversion into reducing sugars. The optimum hydrolysis conditions of liquid acid are at 4% of sulphuric acid, 25:1 of liquid and solid ratio, 175°C of reaction temperature and 120min of ...
Groninger-Poe Fiona P - - 2014
The genome of Agrobacterium tumefaciens C58 encodes twelve members of the enolase superfamily (ENS), eight of which are members of the mandelate racemase (MR) subgroup and, therefore, likely to be acid sugar dehydratases. Using a library of 77 acid sugars for high throughput screening, one protein (UniProt accession ID A9CG74; ...
Kudo Fumitaka F Department of Chemistry, Tokyo Institute of Technology, 2-12-1, O-okayama, Meguro-ku, Tokyo 152-8551, Japan. - - 2014
Covering: up to January, 2014We focus here on β-amino acids as components of complex natural products because the presence of β-amino acids produces structural diversity in natural products and provides characteristic architectures beyond those of ordinary α-l-amino acids, thus generating significant and unique biological functions in nature. In this review, ...
Gatter Michael M Institute of Microbiology, Dresden University of Technology, Zellescher Weg 20b, 01217, - - 2014
Nine potential (fatty) alcohol dehydrogenase genes and one alcohol oxidase gene were identified in Yarrowia lipolytica by comparative sequence analysis. All relevant genes were deleted in Y. lipolytica H222ΔP which is lacking β-oxidation. Resulting transformants were tested for their ability to accumulate ω-hydroxy fatty acids and dicarboxylic acids in the ...
Di Giulio Massimo M Early Evolution of Life Laboratory, Institute of Biosciences and Bioresources, CNR, Via P. Castellino, 111, 80131, Naples, Italy, - - 2014
The phylogenetic analyses as far as the identification of the number of domains of life is concerned have not reached a clear conclusion. In the attempt to improve this circumstance, I introduce the concept that the amino acids codified in the genetic code might be of markers with outstanding phylogenetic ...
Liu Changyong C Biomanufacturing Engineering Laboratory, Graduate School at Shenzhen, Tsinghua University, Shenzhen, - - 2014
Scaffolds are of great importance to the success of tissue engineering. Poly(l-lactide-co-glycolide) acid is one of the most commonly used biopolymers. This study develops a novel low-temperature deposition machine using screw extrusion to fabricate poly(l-lactide-co-glycolide) acid scaffolds. The screw extrusion process of poly(l-lactide-co-glycolide) acid is analysed, and the relationship between ...
Evans Simon J SJ Department of Psychiatry, University of Michigan, United States. Electronic address: - - 2014
Polyunsaturated fatty acids (PUFA) profiles associate with risk for mood disorders. This poses the hypothesis of metabolic differences between patients and unaffected healthy controls that relate to the primary illness or are secondary to medication use or dietary intake. However, dietary manipulation or supplementation studies show equivocal results improving mental ...
Kim Soomin S Department of Chemistry and Nano Science, Ewha Global Top 5 Program, Ewha Womans University, Seoul 120-750, Korea. - - 2014
The terminal amino groups of peptoids have often been protected with acetyl groups to improve cell permeability and therapeutic potential, and to prevent the poisoning of the catalysts in organometallic reactions. Interestingly, the unusual truncation of the terminal peptoid unit has sometimes been encountered when the acetylated linear peptoids were ...
Wang Hou H College of Environmental Science and Engineering, Hunan University, Changsha, 410082, Hunan, People's Republic of - - 2014
Natural adsorbent (Cinnamomum camphora sawdust) modified by organic acid (oxalic acid, citric acid, and tartaric acid) was investigated as a potential adsorbent for the removal of hazardous malachite green (MG) dye in aqueous media in a batch process. The extent of MG adsorption onto modified sawdust increased with increasing organic ...
Makida Yusuke Y EaStCHEM School of Chemistry, University of St Andrews, North Haugh, St Andrews, KY16 9ST, UK. - - 2014
A nickel/N-heterocyclic carbene (NHC) catalysed carboxylation of aryl-, heteroaryl- and alkenylboronates, affording the corresponding carboxylic acids, has been developed. This transformation proceeds under one atmosphere of CO2 with a broad range of substrates and exhibits good functional group compatibility.
Zhou Shengbin S State Key Laboratory of Drug Research, CAS Key Laboratory of Receptor Research Department, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zuchongzhi Road, Shanghai 201203 (P. R. - - 2014
The first chemical method for resolution of N,C-unprotected β-amino acids was developed through enantioselective formation and disassembly of nickel(II) complexes under operationally convenient conditions. The specially designed chiral ligands are inexpensive and can be quantitatively recycled along with isolation of the target β-substituted-β-amino acids in good yields and excellent enantioselectivity. ...
Stefański T T Academic Centre for Dentistry, Bytom, - - 2014
Frequent consumption of acidic beverages is related to excessive tooth wear, namely dental erosion. Preventive measures may involve reduction or elimination of acidic drink consumption. However, the success of this approach is difficult to achieve as it is highly dependent on patient compliance. Therefore, a practical way of minimizing the ...
Jeennor Sukanya S Fermentation Technology and Biochemical Engineering Laboratory, Bioresources Technology Unit, National Center for Genetic Engineering and Biotechnology, National Science and Technology Development Agency, Thailand Science Park, Pathum Thani - - 2014
We identified a novel elongase gene from a selected strain of the Oomycete, Pythium sp. BCC53698. Using a PCR approach, the cloned gene (PyElo) possessed an open reading frame (ORF) of 834 bp encoding 277 amino acid residues. A similarity search showed that it had homology with the PUFA elongases ...
Jia Juntao J Technological Center, Shandong Entry-Exit Inspection and Quarantine Bureau, 266002, Qingdao, - - 2014
Vibrio parahaemolyticus is a common foodborne bacterial pathogen, which survives in cold environments and is sometimes difficult to culture. Fatty acid analysis under cold stress was conducted for several V. parahaemolyticus strains using gas chromatography/mass spectrometry, and the results were compared with those of the controls. All the fatty acid ...
Park Hyunwoo H Department of Agronomy and Horticulture, University of Nebraska-Lincoln, Lincoln, NE, USA; Center for Plant Science Innovation, University of Nebraska-Lincoln, Lincoln, NE, - - 2014
Soybean (Glycine max (L.) Merr) is valued for both its protein and oil, whose seed is composed of 40% and 20% of each component, respectively. Given its high percentage of polyunsaturated fatty acids, linoleic acid and linolenic acid, soybean oil oxidative stability is relatively poor. Historically food processors have employed ...
Catenazzi Maria Chiara E MC Department of Biology, University of York, Heslington, York, YO10 5DD, - - 2014
Neisseria meningitidis is an important human pathogen that is capable of killing within hours of infection. Its normal habitat is the nasopharynx of adult humans. Here we identify a genomic island (the prp gene cluster) in N. meningitidis that enables this species to utilize propionic acid as a supplementary carbon ...
Vivek Hamse K HK Department of Biotechnology, Sri Jayachamarajendra College of Engineering, Mysore-570006, - - 2014
Secretory Phospholipases A2 (sPLA2's) are present in snake venoms, serum, biological fluids of patients with various inflammatory, autoimmune and allergic disorders. Lipid mediators, in the inflammatory processes have potential value of controlling phospholipids metabolism through sPLA2 inhibition. Thus it demands the need for screening of potential leads for sPLA2 inhibition. ...
Sett Arghya A Bioengineering Research Laboratory, Department of Biotechnology, Indian Institute of Technology Guwahati, Guwahati, Assam, 781039, - - 2014
Efforts to replace conventional chromatographic methods for environmental monitoring with cheaper and easy to use biosensors for precise detection and estimation of hazardous environmental toxicants, water or air borne pathogens as well as various other chemicals and biologics are gaining momentum. Out of the various types of biosensors classified according ...
Yu Zhiliang Z College of Biological and Environmental Engineering, Zhejiang University of Technology, Hangzhou, China, - - 2014
L-Amino acid oxidase (LAAO) is widely distributed in many different organisms and found to play important biological roles, thus attracting a great deal of attention for characterization of its activity. Diverse detection methods with their own properties have been established. This review advanced different LAAO activity assays based on substrate ...
Gerbig Dennis - - 2014
Quantum mechanical tunneling governs the C-O bond rotamerization of simple alkyl and aryl carboxylic acid conformers at cryogenic temperatures. In this study, we report tunneling investigations on a series of electronically different α-ketocarboxylic acids including glyoxylic, pyruvic, cyclopropylglyoxylic and phenylglyoxylic acid in solid Ar and Ne as host materials at ...
Govindarajan Sridhar - - 2014
We have used Design of Experiments (DOE) and systematic variance to efficiently explore glutathione transferase substrate specificities caused by amino acid substitutions. Amino acid substitutions selected using phylogenetic analysis were synthetically combined using a DOE design to create an information-rich set of gene variants, termed infologs. We used machine learning ...
Ferroni Claudia C CNR Institute of Organic Synthesis and Photoreactivity, Via P. Gobetti, 101, Bologna, 40129, - - 2014
Pyrethroids are synthetic derivatives of naturally occurring pyrethrum. These molecules are widely used in agriculture for ant, flies and mosquito control and for lawn and garden care. Pyrethroids are the optically active esters of 2,2-dimethyl-3-(2-methylpropenyl)-cyclopropane carboxylic acid, also known as chrysanthemic acid. However, their intense use resulted in the development ...
Kusche Daniel D Kassel University, Faculty of Organic Agricultural Sciences, Nordbahnhofstraße 1a, 37213, Witzenhausen, - - 2014
Intensification of organic dairy production leads to the question if the implementation of intensive feeding incorporating maize silage and concentrates was altering milk quality. Therefore the fatty acid (FA) profiles and antioxidants (AO) of milk on 24 farms divided in 4 system groups in 3 replications (n = 71) during outdoor period ...
Yan Bo B Innovative Catalysis Program, Key Lab of Organic Optoelectronics & Molecular Engineering, Department of Chemistry, Tsinghua University, Beijing, 10084 (PR - - 2014
Gas-phase dehydration of lactic acid (LA) to acrylic acid (AA) was investigated over alkali-exchanged β zeolite (Mx Na1-x β, M=Li(+) , K(+) , Rb(+) , or Cs(+) ) of different exchange degrees (x). The reaction was conducted under varying conditions to understand the catalyst selectivity for AA production and trends ...
de la Torre Fernando F Departamento de Biología Molecular y Bioquímica, Facultad de Ciencias, Universidad de Málaga, Campus Universitario de Teatinos, 29071 Málaga, - - 2014
In the chloroplasts and in non-green plastids of plants, aspartate is the precursor for the biosynthesis of different amino acids and derived metabolites that play distinct and important roles in plant growth, reproduction, development or defence. Aspartate biosynthesis is mediated by the enzyme aspartate aminotransferase (EC 2.6.1.1), which catalyses the ...
Drexler Chad I - - 2014
Hybrid chemical patterning strategies that combine the sophistication of lithography with the intrinsic precision of molecular self-assembly are of broad interest for applications including nanoelectronics and bioactive surfaces. This approach is exemplified by the molecular-ruler process where the sequential deposition of mercaptoalkanoic acid molecules and coordinated metal ions is integrated ...
Rajaram Sujatha S From the Department of Nutrition, School of Public Health, Loma Linda University, Loma Linda, - - 2014
α-Linolenic acid (ALA) is an n-3 (ω-3) fatty acid found mostly in plant foods such as flaxseed, walnuts, and vegetable oils, including canola and soybean oils. Most of the health benefits observed for n-3 fatty acids have been attributed to the marine-derived long-chain n-3 fatty acids eicosapentaenoic acid (EPA) and ...
Lund Peter P School of Biosciences, University of Birmingham, Birmingham, - - 2014
As part of their lifecycle neutralophilic bacteria are often exposed to varying environmental stresses, amongst which fluctuations in pH are the most frequent. In particular, acid environments can be encountered in many situations from fermented food to the gastric compartment of the animal host. Herein we review the current knowledge ...
Choi Youngbo Y World Class University Program of Chemical Convergence for Energy & Environment, Institute of Chemical Processes, School of Chemical and Biological Engineering, College of Engineering, Seoul National University, Seoul 151-742, Republic of Korea. - - 2014
A facile and efficient approach to prepare hierarchically and radially mesoporous nano-catalysts with tunable acidic properties has been successfully developed. The nanospheres show excellent catalytic performance for the acid catalysed reactions, i.e. cracking of 1,3,5-triisopropylbenzene and hydrolysis of sucrose.
Harris William S WS From Health Diagnostic Laboratory Inc, Richmond, VA; OmegaQuant Analytics LLC, Sioux Falls, SD; and Department of Medicine, Sanford School of Medicine, University of South Dakota, Sioux Falls, - - 2014
The long chain n-3 (omega-3) fatty acids eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), although originally synthesized by microorganisms in the oceans, are primarily obtained from the consumption of fish. Vegetarians, by definition, do not eat fish and thus consume virtually no EPA and DHA. Because conversion of the plant-derived ...
Waldron Nick R NR Children's Surgical Centre, Phnom Penh, Cambodia. Electronic address: - - 2014
Acid violence is the deliberate use of acid to attack another human being. Such attacks leave a terrible human, medical and surgical legacy. This study, from one of the largest cohorts of acid attack victims to date, provides insights into Cambodia's unique demographics of such attacks, as well as the ...
Gavara Raquel - - 2014
In the frame of the metamorphosis chemistry, where complexity is achieved at the bottom, a multistate system based on 4'-carboxy-7-hydroxyflavylium is described. Twelve species reversibly interconverted by pH and light stimuli were identified at the equilibrium or as transients. The carboxylic substituent deprotonates at moderately acidic pH values and by ...
Thompson R Adam RA Bredesen Center for Interdisciplinary Research and Graduate Education, The University of Tennessee, Knoxville, TN, - - 2014
Biodiesels in the form of fatty acyl ethyl esters (FAEEs) are a promising next generation biofuel due to their chemical properties and compatibility with existing infrastructure. It has recently been shown that expression of a bacterial acyl-transferase in the established industrial workhorse Saccharomyces cerevisiae can lead to production of FAEEs ...
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