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Sun Bingbing B Beijing National Laboratory for Molecular Sciences, Key Lab of Analytical Chemistry for Living Biosystems, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, PR China; College of Food Sciences and Engineering, Shandong Agricultural University, Tai'an, Shandong 271018, PR - - 2014
New kinds of amino acid ionic liquids (AAILs) with pyridinium as cations and l-lysine (l-Lys) as anion have been developed as the available chiral ligands coordinated with Zn(II) in chiral ligand-exchange capillary electrophoresis (CLE-CE). Four kinds of AAILs, including [1-ethylpyridinium][l-lysine], 1-butylpyridinium][l-lysine], [1-hexylpyridinium][l-lysine] and 1-[octylpyridinium][l-lysine], were successfully synthesized and characterized by ...
Ananthan Bakthavachalam - - 2014
By combining a novel acid-promoted rearrangement of acetal functionality with the controlled installation of the epoxide unit to create the pivotal epoxide intermediates in enantiomerically pure form, a simple, concise, flexible, and readily scalable enantiodivergent synthesis of (+)- and (-)-shikimic acids and (+)- and (-)-4-epi-shikimic acids has emerged. Not only ...
Schäffner Benjamin B Evonik Industries AG, Paul-Baumann-Str. 1, 45772 Marl (Germany) http://www.evonik.com http://ww.creavis.de. - - 2014
Carbon dioxide can be used in various ways as a cheap C1 source. However, the utilization of CO2 requires energy or energy-rich reagents, which leads to further emissions, and therefore, diminishes the CO2 -saving potential. Therefore, life cycle assessment (LCA) is required for each process that uses CO2 to provide ...
Alvarez-Ordóñez Avelino A School of Microbiology, University College Cork, Cork, Ireland; Food for Health Ireland, University College Cork, Cork, Ireland. Electronic address: - - 2014
Cronobacter sakazakii is a foodborne pathogenic microorganism associated with sporadic cases of neonatal meningitis, necrotising enterocolitis, septicaemia, bloody diarrhoea and brain abscesses acquired through the consumption of contaminated powdered infant formula (PIF). This study aimed to investigate the growth of C. sakazakii DPC6529, a particularly stress tolerant clinical isolate, in ...
De Bratati B Phytochemistry and Pharmacognosy research Laboratory, Department of Botany, University of Calcutta, 35, Ballygunge Circular Road, Kolkata 700019, India. Electronic address: - - 2014
The aim of the present work was to analyze metabolic diversity in 26 different indica varieties of rice grains. Seventy-six metabolites could be identified in the methanol extracts of each of the rice varieties analyzed by gas chromatography-mass spectrometry. These metabolites included 9 sugars/sugar alcohols, 17 amino acids/derivatives, 18 fatty ...
Abdullah Bashar Mudhaffar - - 2014
Vegetable oils have different unique properties owing to their unique chemical structure. Vegetable oils have a greater ability to lubricate and have higher viscosity indices. Therefore, they are being more closely examined as base oil for biolubricants and functional fluids. In spite of their many advantages, vegetable oils suffer from ...
Wendell Stacy Gelhaus SG Asthma Institute, UPMC, Department of - - 2014
Fatty acids and consequently diet play an essential role in the formation of inflammatory mediators involved in the pathogenesis of asthma. Because intake variations of omega-6 (n-6) and omega-3 (n-3) fatty acids ultimately determine cell membrane incorporation, changes in diet have the potential to modify downstream production of inflammatory mediators ...
Ni Xiang X State Key Laboratory of Elemento-Organic Chemistry, Department of Chemistry, Nankai University, and Collaborative Innovation Center of Chemical Science and Engineering , Tianjin 300071, - - 2014
A number of popular squaramide organocatalysts' acidities were determined by an overlapping indicator method in DMSO via UV spectrophotometric titrations. The pKa values are in the range of 8.37-16.46. The results may be helpful for the rational design and development of squaramide type new catalysts.
Dunn Michael Frederick MF Centro de Ciencias Genómicas, UNAM , Cuernavaca , - - 2014
Abstract Rhizobia are bacteria in the α-proteobacterial genera Rhizobium, Sinorhizobium, Mesorhizobium, Azorhizobium and Bradyrhizobium that reduce (fix) atmospheric nitrogen in symbiotic association with a compatible host plant. In free-living and/or symbiotically associated rhizobia, amino acids may, in addition to their incorporation into proteins, serve as carbon, nitrogen or sulfur sources, ...
Ding Ya Y 1] Department of Chemistry, University of Massachusetts Amherst, 710 North Pleasant St, Amherst, Massachusetts, MA 01003, USA [2] Key Laboratory of Drug Quality Control and Pharmacovigilance, China Pharmaceutical University, Ministry of Education, Nanjing, Jiangsu 210009, China - - 2014
Gold nanoparticles provide an attractive and applicable scaffold for delivery of nucleic acids. In this review, we focus on the use of covalent and noncovalent gold nanoparticle conjugates for applications in gene delivery and interfering RNA technologies. We also discuss challenges in nucleic acid delivery, including endosomal entrapment/escape and active ...
Nguyen Thanh V TV Department of Chemistry, Curtin University , Perth, WA 6102, - - 2014
A new method for the nucleophilic substitution of alcohols and carboxylic acids using aromatic tropylium cation activation has been developed. This article reports the use of chloro tropylium chloride for the rapid generation of alkyl halides and acyl chlorides under very mild reaction conditions. It demonstrates, for the first time, ...
Wilcox C C Cochrane Medical Education Centre, Cardiff University School of Medicine, Cardiff, - - 2014
Bile acid malabsorption (BAM) is a common, yet under-recognised, cause of chronic diarrhoea, with limited guidance available on the appropriate management of patients with BAM. To summarise the evidence supporting different treatments available for patients with bile acid malabsorption, noting their impact on clinical outcomes, tolerability and associated side effects. ...
Khedri Zahra Z Department of Chemistry, University of California, One Shields Avenue, Davis, CA 95616, - - 2014
Modifications at the glycerol side chain of sialic acid in sialosides modulate their recognition by sialic acid-binding proteins and sialidases. However, limited work has been focused on the synthesis and functional studies of sialosides with C7-modified sialic acids. Here we report chemical synthesis of C4-modified ManNAc and mannose and their ...
Balakrishnan Madhesan M Energy Biosciences Institute, Department of Chemical and Biomolecular Engineering, University of California at Berkeley, CA 94720 - - 2014
Synthesis of transportation fuel from lignocellulosic biomass is an attractive solution to the green alternative-energy problem. The production of biodiesel, in particular, involves the process of upgrading biomass-derived small molecules to diesel precursors containing a specific carbon range (C11 -C23 ). Herein, a carbon-upgrading process utilizing an acid-catalyzed condensation of ...
Lipfert Jan J Department of Bionanoscience, Kavli Institute of Nanoscience, Delft University of Technology, 2628 CJ Delft, and Netherlands and Department of Physics and Center for the NanoScale, University of Munich, 80799 Munich, Germany; email: - - 2014
Ions surround nucleic acids in what is referred to as an ion atmosphere. As a result, the folding and dynamics of RNA and DNA and their complexes with proteins and with each other cannot be understood without a reasonably sophisticated appreciation of these ions' electrostatic interactions. Because the ion atmosphere ...
Schade Matthias M Humboldt-Universität zu Berlin, Institut für Biologie, Invalidenstr. 42, 10115 Berlin, - - 2014
Lipophilic nucleic acids have become a versatile tool for structuring and functionalization of lipid bilayers and biological membranes as well as cargo vehicles to transport and deliver bioactive compounds, like interference RNA, into cells by taking advantage of reversible hybridization with complementary strands. This contribution reviews the different types of ...
Harohally Nanishankar V NV Food Safety and Analytical Quality Control Laboratory, CSIR-CFTRI, KRS Road, Mysore 570020, Karnataka, India. Electronic address: - - 2014
An efficient and practical protocol for the synthesis of Amadori ketoses N-(1-deoxy-d-fructose-1-yl) amino acid (amino acid=l-valine (1), l-leucine (2), l-isoleucine (3), l-tryptophan (4), l-phenylalanine (5), l-arginine (6) has been accomplished by employing ZnCl2 as a catalyst. The developed method circumvents protection and deprotection steps as well as tedious ion-exchange and ...
Sasaki M K MK NAPTISA/Center for Nuclear Energy in Agriculture, University of Sao Paulo, Piracicaba, - - 2014
An automated multi-pumping flow system is proposed for the chemiluminometric determination of ascorbic acid in pharmaceutical formulations, relying on the ability of semiconductor nanocrystals to generate short-lived reactive species upon photo-irradiation. A photo-unit based on visible-light-emitting diodes is used to photo-excite cadmium telluride (CdTe) quantum dots capped with glutathione, leading ...
Shao Zhuzhou Z College of Chemistry and Pharmaceutical Sciences, Qingdao Agricultural University, Qingdao, 266109, China. chemjxiao@gmail.com - - 2014
The tandem Michael addition/decarboxylation of (thio)coumarin-3-carboxylic acids with indoles has been developed and the biologically important indole-3-substituted dihydrocoumarins were obtained in good to excellent yields under catalyst-free conditions.
Hennum Martin - - 2014
The asymmetric nucleophilic 1,2-addition of (S)-N-benzylidene-2-methylpropane-2-sulfinamide with methylmagnesium bromide and methyllithium has been investigated using DFT(B3LYP) computations. The calculated ratio of the two diastereomers agrees with experimental observations and the factors that determine the diastereomeric ratio are discussed. The preference for the E isomer and the rapid equilibrium between the ...
Martínez-Moreno Rubén R Instituto de Ciencias de la Vid y del Vino (CSIC, Universidad de La Rioja, Gobierno de la Rioja), C/Madre de Dios, 51, 26006 Logroño, La Rioja, - - 2014
Nitrogen limitation is the most common cause for stuck or sluggish fermentation in winemaking, and it is usually dealt with by supplementing grape juice with either ammonium salts or organic nutrients. These practices have a direct impact on both fermentation kinetics and the sensorial features of the final product. The ...
Bonafé Luisa L aCenter for Molecular Diseases, Lausanne University Hospital bAdult Intensive Care & Burns, Lausanne University Hospital, Lausanne, Switzerland cDivision of Endocrinology, Diabetes, and Bone Disease, Icahn School of Medicine at Mount Sinai, New York, New York, - - 2014
New insight in mitochondrial physiology has highlighted the importance of mitochondrial dysfunction in the metabolic and neuroendocrine changes observed in patients presenting with chronic critical illness. This review highlights specifically the importance of carnitine status in this particular patient population and its impact on beta-oxidation and mitochondrial function. The main ...
Thumser Alfred E AE aDepartment of Biochemistry and Physiology bDepartment of Nutritional Sciences, Faculty of Health and Medical Sciences, University of Surrey, Guildford, - - 2014
The purpose of this study is to review recent evidence for the role of the cytosolic fatty acid binding proteins (FABPs) as central regulators of whole-body metabolic control. Dysregulated FABPs have been associated with a number of diseases, including obesity and nonalcoholic fatty liver disease (FABP1, FABP2, FABP4), cardiovascular risk ...
Di Girolamo Filippo Giorgio FG aClinica Medica AOUTS, Department of Medical Sciences, University of Trieste bOrthopedic Unit AOUTS cGeriatric Unit AOUTS, Trieste, - - 2014
The increased age observed in most countries, with the associated higher rates of chronic illnesses and cancer, and a diffuse sedentary lifestyle, will increase the number of patients with clinically relevant anabolic resistance, sarcopenia and its complications. The need for solutions to this major health issue is, therefore, pressing. The ...
Keum Nana N Department of Nutrition and Epidemiology, Harvard School of Public Health, Boston, - - 2014
The U.S. has been reported as the only country experiencing a decline in incidence rates of colorectal cancer (CRC), despite increasing prevalence of CRC major risk factors, including the Western dietary pattern and obesity. This paper presents a hypothesis that improved folate status in the U.S. is the factor that ...
Bardaweel Sanaa K - - 2014
Homochirality is fundamental for life. L-Amino acids are exclusively used as substrates for the polymerization and formation of peptides and proteins in living systems. However, D- amino acids were recently detected in various living organisms, including mammals. Of these D-amino acids, D-serine has been most extensively studied. D-Serine was found ...
Kwong Raymond W M RW Department of Biology, University of Ottawa, 30 Marie Curie, Ottawa, ON, Canada, K1N - - 2014
Ionic regulation and acid-base balance are fundamental to the physiology of vertebrates including fish. Acidification of freshwater ecosystems is recognized as a global environmental problem, and the physiological responses to acid exposure in a few fish species are well characterized. However, the underlying mechanisms promoting ionic and acid-base balance for ...
Hussain Shahzad S Drugs Control and Traditional Medicines Division, National Institute of Health, Islamabad, - - 2014
Medicinal plants are believed to be a precious natural reservoir as they are assumed to have paranormal effects for the mankind. Moringa oleifera grows throughout most of the tropics and has numerous industrial and medicinal uses. This review acquaints with the consequence of fera (Moringaceae), a fast growing medicinal plant ...
Salim Vonny V Department of Biological Sciences, 500 Glenridge Avenue, Brock University, St. Catharines, Ontario L2S 3A1, Canada. Electronic address: - - 2014
Iridoids are key intermediates required for the biosynthesis of monoterpenoid indole alkaloids (MIAs), as well as quinoline alkaloids. Although most iridoid biosynthetic genes have been identified, one remaining three step oxidation required to form the carboxyl group of 7-deoxyloganetic acid has yet to be characterized. Here, it is reported that ...
Pinto Andrea A Dipartimento di Scienze Farmaceutiche DISFARM, Università degli Studi di Milano, Via Mangiagalli 25, 20133 Milano, Italy. Electronic address: - - 2014
A convenient synthesis of four new enantiomerically pure acidic amino acids is reported and their affinity at ionotropic glutamate receptors was determined. The new compounds are higher homologues of glutamic acid in which the molecular complexity has been increased by introducing an aromatic/heteroaromatic ring, that is a phenyl or a ...
Garrett Andrew R AR Department of Microbiology and Molecular Biology, Brigham Young University, 855 WIDB, Provo, UT 84602, - - 2014
Epidemiological studies show a positive correlation between oxidative stress and chronic disease development such as heart disease and cancer. While several antioxidant compounds with varying physical and chemical characteristics are able to reduce oxidative stress in biological systems, relatively few studies have been performed to examine the structural characteristics that ...
Ragavendra Thayappa Raju - - 2014
Use of acids and other caustic substances in destroying the human body to avoid personal identification is drawing great deal of attention in recent times. With rapid industrial growth, incidence of industrial disasters has increased. In an event of chemical industry disaster, human identification can become a challenge. Embedding bar ...
Kalinic Dubravka - - 2014
Aim. To explore the association between plasma fatty acids composition and the severity of clinical symptoms in Croatian war veterans with posttraumatic stress disorder (PTSD). Methods. This cross-sectional study included 62 men diagnosed with PTSD caused by combat activities during the War in Croatia 1991-1995. Clinician-Administered PTSD Scale (CAPS), Hamilton ...
Malan André A Institute for Cellular and Integrative Neurosciences, CNRS and University of Strasbourg, 5 Rue Blaise Pascal, 67084 Strasbourg Cedex, - - 2014
The conquest of land has endowed air-breathers with the capability to utilize ventilation not only to acquire oxygen but also to control blood and intracellular acid-base state. Hypercapnic acidosis (resulting from ventilatory control and/or behavioral choice), thus, has become a universal component of hypometabolic states in air-breathers, with inhibitory and/or ...
He Yanqing Y State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, 130 Meilong Road, Shanghai 200237, - - 2014
Impregnation of lignocellulose materials with dilute acid solution is a routine operation in conventional dilute acid pretreatment. The dry dilute acid pretreatment (DDAP) at high solids content up to 70% is naturally considered to require longer impregnation time. In this study, a co-currently feeding operation of corn stover and dilute ...
Wang Yechun Y Donald Danforth Plant Science Center, 975 North Warson Road, Saint Louis, MO, 63132, - - 2014
Malonyl-CoA is the essential building block of natural products such as fatty acids, polyketides, and flavonoids. Engineering the biosynthesis of fatty acids is important for biofuel production while that of polyketides provides precursors of medicines and nutritional supplements. However, microorganisms maintain a small amount of cellular malonyl-CoA, which could limit ...
Hibi Makoto M Industrial Microbiology, Graduate School of Agriculture, Kyoto University, Kitashirakawa-oiwakecho, Sakyo-ku, Kyoto, 606-8502, - - 2014
The asymmetric hydroxylation of inactive carbon atoms is still an important reaction in the industrial synthesis of valuable chiral compounds such as pharmaceuticals and fine chemicals. Applications of monooxygenation enzymes, like cytochrome P450 monooxygenases, flavin-containing monooxygenases, and Fe(II)/α-ketoglutarate-dependent dioxygenases (Fe/αKG-DOs), are strongly desired as hydroxylation biocatalysts because they have great ...
Finkbeiner Peter P Institut für Organische Chemie, Eberhard Karls Universität Tübingen , Auf der Morgenstelle 18, 72076 Tübingen, - - 2014
An efficient electrophilic alkynylation of azlactones (oxazol-5(4H)-ones) is developed using alkynyl(phenyl)iodonium salts as the electrophilic alkyne source. After remarkably short reaction times, the desired alkyne functionalized azlactones are obtained in 60-97% yield and can be transformed easily into a variety of quaternary α-amino acid derivatives.
Kotouńćová Hana H Department of Organic Chemistry, Institute of Chemical Technology, Prague, Technická 5, 16628 Prague 6, Czech Republic. - - 2014
Flavin-catalysed oxidative hydroxylation of substituted arylboronic acids by molecular oxygen with the assistance of hydrazine or ascorbic acid resulted in phenols in high yields. This mild organocatalytic protocol is compatible with a variety of functional groups and it is alternatively usable for transformation of alkylboronic acids to alcohols. Reaction takes ...
Schäfer Gabriel G Laboratorium für Organische Chemie, Department of Chemistry and Applied Biosciences, ETH Zürich , Vladimir Prelog Weg 1-5, 8093 Zürich, - - 2014
Sterically hindered N-acyl, gem-disubstituted amino acids are easily prepared via the addition of organometallic reagents to N-carboxyanhydrides (NCA). The process tolerates a wide variety of functional groups and allows the synthesis of amide products not readily accessible by traditional acylation chemistry. The existence of an isocyanate intermediate was established by ...
Zhou Pan-Pan - - 2014
Nicotinic acid is a well-known pharmaceutical in vitamin B group that has attracted great interest in the past decades due to its significant importance in the treatment of the human diseases like pellagra. Also, nicotinic acid derivatives have been devoted to much attention due to their different pharmaceutical effects in ...
Vilcocq Léa L Centro de Química da Madeira, Universidade da Madeira, Campus da Penteada, 9020-105 Funchal - - 2014
Mild fractionation/pretreatment processes are becoming the most preferred choices for biomass processing within the biorefinery framework. To further explore their advantages, new developments are needed, especially to increase the extent of the hydrolysis of poly- and oligosaccharides. A possible way forward is the use of solid acid catalysts that may ...
Subba Reddy Basireddy Venkata - - 2014
An unprecedented oxa- vs thia- selectivity has been observed in Prins cyclization of 6-mercaptohex-3-en-1-ol with aldehydes. In the presence of a stoichiometric amount of strong Lewis or Bronsted acids,the reaction provides the hexahydro-2H-thieno[3,2-c]pyran skeleton predominantly via oxonium-Prins cyclization. In contrast, a catalytic amount of weak Lewis or Bronsted acids provides ...
Ma Xiao X School of Chemistry, Northeast Normal University, Changchun, 130024 (P. R. China), Fax: - - 2014
Carbon nanotubes (CNTs) have been widely employed as electrode materials in diverse branches of electrochemistry, which are claimed to display dramatically improved electrochemical behaviour compared to the conventional carbon materials. But a series of recent publications have demonstrated that the electrocatalysis of CNTs might be due to the presence of ...
Gualandi Andrea A Dipartimento di Chimica "G. Ciamician", ALMA MATER STUDIORUM, Università di Bologna, Via Selmi 2, 44126, Bologna (Italy), Fax: - - 2014
In recent years there has been an accelerated rate of development in the field of organocatalysis, with asymmetric organocatalysis now reaching full maturity. The invention of new organocatalytic reactions and the exploration of new concepts now appear in tandem with the application of organocatalytic techniques in the synthesis of natural ...
Yang Senpei S CAU & ACC Joint-Laboratory of Space Food, College of Food Science and Nutritional Engineering, Beijing Key Laboratory of Functional Food from Plant Resources, China Agricultural University, Beijing 100083, - - 2014
Under physiological conditions, exogenous chelators such as polyphenols might interact with non-protein bound ferric complexes, such as Fe(III)-citrate. Additionally, Fe(III) and citrate are widely distributed in various fruits and vegetables which are also rich in phenolic acids. In this study, we focus on the interaction between phenolic acids (gallic acid, ...
Xu Yu Y School of Chemistry and Chemical Engineering, Shandong University, Jinan 250100, PR China; Taishan College, Shandong University, Jinan 250100, PR - - 2014
A novel turn-off fluorescent probe based on coumarin and imidazole moiety for extremely acidic conditions was designed and developed. The probe with pKa=2.1 is able to respond to very low pH value (below 3.5) with high sensitivity relying on fluorescence quenching at 460nm in fluorescence spectra or the ratios of ...
Sullivan Michael L ML US Dairy Forage Research Center, US Department of Agriculture, Agricultural Research Service, 1925 Linden Drive, Madison, WI, 53705, USA, - - 2014
Many plants accumulate hydroxycinnamoyl esters to protect against abiotic and biotic stresses. Caffeoyl esters in particular can be substrates for endogenous polyphenol oxidases (PPOs). Recently, we showed that perennial peanut (Arachis glabrata Benth.) leaves contain PPO and identified one PPO substrate, caftaric acid (trans-caffeoyl-tartaric acid). Additional compounds were believed to ...
Fenech Goël G Paris Descartes University, Faculty of Medicine, AP-HP, Diagnosis and Therapeutic Center, Hôtel-Dieu University Hospital, place du Parvis-Notre-Dame, Paris, - - 2014
Hyperuricaemia is commonly found in subjects with cardiovascular disease, but its role as risk factor is very controversial. Although several studies reported serum uric acid as a marker of an underlying pathophysiological process, other studies hypothesis a potential causal link between serum uric acid and cardiovascular diseases. Some studies suggest ...
Guschina Irina A IA School of Biosciences, Cardiff University, Cardiff CF10 3AX, - - 2014
Although there is much knowledge of the enzymology (and genes coding their proteins) of lipid biosynthesis in higher plants, relatively little attention has been paid to regulation. We have demonstrated the important role for cholinephosphate cytidylyltransferase in the biosynthesis of the major extra-plastidic membrane lipid, phosphatidylcholine. We followed this work ...
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