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Kumar Vineet V Chemistry Division, Forest Research Institute, Dehradun-248006 India. Electronic address: - - 2014
Polysaccharides containing uronic acids are of immense biological significance. Colorimetric methods using different chromogens have been explored for uronic acid estimation in polysaccharides but these methods counter numerous difficulties, when neutral sugars are present in substantial amount. The uronic acid content of cold water-soluble polysaccharide (CWSP) and hot water soluble ...
Le Nôtre Jérôme J Chair of Biobased Commodity Chemistry, Wageningen University & Research Centre, P.O. Box 17, 6700AA Wageningen (The Netherlands), Fax: - - 2014
Methacrylic acid, an important monomer for the plastics industry, was obtained in high selectivity (up to 84 %) by the decarboxylation of itaconic acid using heterogeneous catalysts based on Pd, Pt and Ru. The reaction takes place in water at 200-250 °C without any external added pressure, conditions significantly milder than those ...
Wilger Dale J DJ Department of Chemistry, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599-3290, - - 2014
The direct anti-Markovnikov addition of strong Brønsted acids to alkenes remains an unsolved problem in synthetic chemistry. Here, we report an efficient organic photoredox catalyst system for the addition of HCl, HF and also phosphoric and sulfonic acids to alkenes, with complete regioselectivity. These transformations were developed using a photoredox ...
van Elst Kim K Department of Translational Neuroscience Department of Cognitive Neuroscience, Nijmegen, The - - 2014
K. van Elst, H. Bruining, B. Birtoli, C. Terreaux, J.K. Buitelaar and M.J. Kas. Food for thought; dietary changes in essential fatty acid ratios and the increase in Autism Spectrum Disorders. NEUROSCI BIOBEHAV REV 37 (9) XXX-XXX, 2014 The last decades have shown a spectacular and partially unexplained rise in ...
Takeda Ryosuke R Hamari Chemicals Ltd, 1-4-29 Kunijima, Higashi-Yodogawa-ku, Osaka, Japan - - 2014
This work presents the first chemical approach for the resolution of α-amino acids offering the following advantages: (1) The specially designed resolving reagent is derived from α-(phenyl)ethylamine, the most inexpensive chiral auxiliary, which can be recycled and reused, rendering the cost structure of the complete process very attractive; (2) the ...
Saito Takao T Department of Chemistry, Faculty of Science, Tokyo University of Science, Kagurazaka, Shinjuku-ku, Tokyo 162-8601, Japan. tsaito@rs.kagu.tus.ac.jp - - 2014
A new approach towards the synthesis of indole derivatives via triflic acid-promoted cycloisomerization with rearrangement of 2-(alkyn-1-yl)phenyl isothiocyanates and 2-(alkyn-1-yl)phenyl isocyanates has been achieved. By this methodology, structurally diverse types of indole derivatives such as thieno- and furo-indoles, spiro-indolethiones, spiro-oxindoles, and 3-alkylidene-oxindoles were synthesized.
Tateishi-Karimata Hisae H Frontier Institute for Biomolecular Engineering Research (FIBER), Konan University, 7-1-20 Minatojimaminamimachi, Kobe 650-0047, - - 2014
Nucleic acids have become a powerful tool in nanotechnology because of their conformational polymorphism. However, lack of a medium in which nucleic acid structures exhibit long-term stability has been a bottleneck. Ionic liquids (ILs) are potential solvents in the nanotechnology field. Hydrated ILs, such as choline dihydrogen phosphate (choline dhp) ...
Pu Fang F State Key Laboratory of Rare Earth Resource Utilization and Laboratory of Chemical Biology, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, Jilin, 130022, - - 2014
Logic gates can convert input signals into a defined output signal, which is the fundamental basis of computing. Inspired by molecular switching from one state to another under an external stimulus, molecular logic gates are explored extensively and recognized as an alternative to traditional silicon-based computing. Among various building blocks ...
Niu Wei W Department of Chemistry, University of Nebraska-Lincoln , Lincoln, Nebraska 68588, United - - 2014
Biocatalytic syntheses are increasingly explored as the alternate platform of chemical production in order to address the sustainable development challenge faced by the current chemical industry. Here, we report the design and implementation of an artificial pathway to convert lactic acid into 1,2-propanediol. It circumvents a highly cytotoxic intermediate that ...
Wu Changyan - - 2014
Preparation of biopolymer based catalysts for the conversion of carbohydrate polymers to new energies and chemicals is a hot topic nowadays. With the aim to develop an ecological method to converse xylose into furfural without use of inorganic acids, biopolymer-derived catalyst (lignosulfonic acid) was successfully used to catalyze xylose into ...
Yang Guoqiang - - 2014
meta-C-H olefination, arylation and acetoxylation of indolines have been developed using nitrile-containing templates. The combination of a mono-protected amino acid ligand and the nitrile template attached at the indolinyl nitrogen via a sulfonamide linkage is crucial for the meta-selective C-H functionalization of electron-rich indolines that are otherwise highly reactive toward ...
Gordún Elena E Department of Agri-Food Engineering and Biotechnology, Universitat Politècnica de Catalunya, - - 2014
The microbiological culture-dependent characterization and physicochemical characteristics of laboratory sourdough prepared with grape (GS) were evaluated and compared with apple (AS) and yogurt (YS), which are the usual Spanish sourdough ingredients. Ripe GS took longer than AS and YS to reach the appropriate acidity and achieved lower values of lactic ...
Biely Peter P Institute of Chemistry, Center of Glycomics, Slovak Academy of Sciences, Dúbravská cesta 9, SK-84538, Bratislava, - - 2014
Expression of a Trichoderma reesei gene coding for a putative GH30 xylanase in Aspergillus oryzae led to isolation and purification of a novel xylanase exhibiting catalytic properties different from those of the previously characterized GH30 xylanase XYN IV of T. reesei. The novel enzyme, named XYN VI, exhibited catalytic properties similar to appendage-dependent GH30 glucuronoxylanases previously recognized ...
Scharpf Robert B - - 2014
Hyperuricemia is associated with multiple diseases, including gout, cardiovascular disease, and renal disease. Serum urate is highly heritable, yet association studies of single nucleotide polymorphisms (SNPs) and serum uric acid explain a small fraction of heritability. Whether copy number polymorphisms (CNPs) contribute to uric acid levels is unknown. We assessed ...
Chakrapani Kalapu K Department of Inorganic and Physical chemistry, Indian Institute of Science, Bangalore, India. - - 2014
Iridium nanostructures with different morphologies are synthesized by a simple, environmentally friendly approach in aqueous media under mild conditions. The morphology dependent electrocatalytic activity of Ir nanochains and nanoparticles towards oxygen reduction reaction (ORR) has been demonstrated in both acidic and alkaline media. Comparative electrochemical studies reveal that nanochains exhibit ...
Sugimoto Mitsushige M First Department of Medicine, Hamamatsu University School of Medicine, 1-20-1 Handayama, Higashi-ku, Hamamatsu, 431-3192, Japan, - - 2014
The aim of therapeutic regimens using proton pump inhibitors (PPIs) in patients with acid-related diseases is to potently inhibit acid secretion for the full 24 h. However, optimum treatment is still unclear because the pharmacodynamics of PPIs differ among CYP2C19 genotypes and most of the previous studies have had loss of ...
Blazeck John J McKetta Department of Chemical Engineering, The University of Texas at Austin, 200 E Dean Keeton St. Stop C0400, Austin, TX, 78712, - - 2014
Renewable alternatives for petroleum-derived chemicals are achievable through biosynthetic production. Here, we utilize Saccharomyces cerevisiae to enable the synthesis of itaconic acid, a molecule with diverse applications as a petrochemical replacement. We first optimize pathway expression within S. cerevisiae through the use of a hybrid promoter. Next, we utilize sequential, ...
Bayr S S University of Jyväskylä, Department of Biological and Environmental Science, P.O. Box 35, FI-40014 University of Jyväskylä, Finland. Electronic address: - - 2014
In this study, mono-digestion of rendering wastes and co-digestion of rendering wastes with potato pulp were studied for the first time in continuous stirred tank reactor (CSTR) experiments at 55°C. Rendering wastes have high protein and lipid contents and are considered good substrates for methane production. However, accumulation of digestion ...
Wen Yao-Tseng YT Department of Environmental and Occupational Health, College of - - 2014
Streptococcus pyogenes is responsible for various diseases. During infection, bacteria must adapt to adverse environments, such as the acidic environment. Acidic stimuli may stimulate S. pyogenes to invade into deeper tissue. However, how this acidic stimulus causes S. pyogenes to manipulate its secretome for facilitating invasion remains unclear. The dynamic ...
Ryckewaert Lucie L School of Pharmaceutical Sciences, University of Geneva, University of Lausanne, Quai Ernest-Ansermet 30, CH-1211 Geneva 4, Switzerland. Electronic address: - - 2014
Ginkgolic acids and urushiols are natural alkylphenols known for their mutagenic, carcinogenic and genotoxic potential. However, the mechanism of toxicity of these compounds has not been thoroughly elucidated so far. Considering that the SIRT inhibitory potential of anacardic acids has been hypothesized by in silico techniques, we herein demonstrated through ...
Hanke Thomas T Institute of Pharmaceutical Chemistry, Goethe-University Frankfurt, Max-von-Laue-Str. 9, D-60438 Frankfurt am Main, - - 2014
The concept of dual PPARα/γ activation was originally proposed as a new approach for the treatment of the metabolic syndrome. However, recent results indicated that PPARα as well as PPARγ activation might also be beneficial in the treatment of inflammatory diseases and cancer. We have recently identified aminothiazole-featured pirinixic acids ...
Ren Long L State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Xue Yuan Road 38, Beijing 100191 - - 2014
A highly selective Pd/Cu-cocatalyzed aerobic oxidative carbonylative homocoupling of arylboronic acids has been developed. This method employs a simple catalytic system, readily available boronic acids as the substrates, molecular oxygen as the oxidant, and 1 atm of CO/O2 , which makes this method practical for further applications.
Gu Da-Wei DW Shanghai Center for Systems Biomedicine, Ministry of Education Key Laboratory of Systems Biomedicine, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai 200240, China. - - 2014
The annulation of heteroaromatic β-halo-α,β-unsaturated carboxylic acids with alkynes proceeds efficiently in the presence of Cu(OAc)2·H2O as a catalyst to afford the corresponding indolo[2,3-c]pyrane-1-ones and thieno[2,3-c]pyrane-7-ones in moderate to good yields. This strategy offers a simple and efficient route for the synthesis of indolo[2,3-c]pyrane-1-ones and thieno[2,3-c]pyrane-7-ones with good tolerance to ...
Singh Priyanka P Medicinal and Process Chemistry Division, CSIR-Central Drug Research Institute, B.S. 10/1, Jankipuram Extension, Sitapur Road, Lucknow 226031, India. gautam.panda@gmail.com - - 2014
As a result of their easy availability in enantiomerically enriched form and their possession of synthetically transformable diverse functional groups, amino acids have been extensively used by synthetic organic and medicinal chemists as a chiral pool for access to heterocycles (monocycles, bicycles or polycycles, either bridged or fused). This review ...
Cuadri A A AA Departamento de Ingeniería Química, Centro de Investigación en Tecnología de Productos y Procesos Químicos (Pro(2) TecS), Campus de 'El Carmen', Universidad de Huelva, 21071 Huelva, - - 2014
The accumulation of phosphogypsum waste from the fertilizer industries, which remain in regulated stacks occupying considerable land resources, is causing significant environment problems worldwide. In that sense, the scientific community is being pressured to find alternative ways for their disposal. In this research, we propose a novel application for phosphogypsum ...
Gao Xu X Key Laboratory for Environmentally Friendly Chemistry and Application of the Ministry of Education, College of Chemistry, Xiangtan University , Hunan 411105, - - 2014
A practical Brønsted acid promoted benzylic C-H functionalization of 2-alkylazaarenes and nucleophilic addition to nitroso compounds was developed under mild conditions. Switched by Brønsted acids, this method can afford azaarene-2-aldimines, azaarene-2-carbaldehyde, or azaarene-2-oximes selectively. No metal, base, oxidant, or other additives were required.
Buter Jeffrey J Statingh Institute for Chemistry, University of Groningen, Nijenborgh 7, 9747 AG Groningen, The Netherlands. - - 2014
The palladium-catalyzed conjugate addition (Michael addition) of ortho-substituted arylboronic acids to β,β-disubstituted cyclic enones, in particular 3-methyl cyclopent-2-enone and 3-methyl cyclohex-2-enone, is reported. With an achiral bipyridine-based palladium catalyst, good yields are obtained with a variety of ortho-substituted arylboronic acids. In the asymmetric version, good to very high enantiomeric excesses ...
Constable Peter D PD College of Veterinary Medicine, University of Illinois at Urbana-Champaign, 2001 South Lincoln Avenue, Urbana, IL 61802, USA. Electronic address: - - 2014
The Henderson-Hasselbalch equation is probably the most famous equation in biology but is more descriptive than mechanistic. The traditional approach to acid-base assessment using the Henderson-Hasselbalch equation provides a clinically useful and accurate method when plasma protein concentrations are within the reference range. The simplified strong ion approach is a ...
Shariatifar Nabi N Department of Environment Health, School of Public Health, Tehran University of Medical Sciences (TUMS), Tehran, - - 2014
The essential oil from aerial parts of Pulicaria gnaphalodes was studied in soybean oil. The aim of this study was to evaluate the antioxidant activitiey of Iranian Pulicaria gnaphalodes essential oil in soybean oil during the storage period. The essential oil obtained from Pulicaria gnaphalodes by hydrodistillation and analyzed by ...
Xu Kuo - - 2014
The natural product oleanolic acid has been widely used for treating hepatopathy in China, whereas its clinical application was confined by poor solubility in water. Inspired by remarkable bioactivities and physical properties of triterpenoid saponins, synthesis and biological evaluation of oleanolic acid oligoglycosides drew considerable attention. In the past several ...
Brousseau-Foley Magali - - 2014
Digital and interdigital corns are common painful foot conditions encountered by podiatrists during the course of their practice. These corns can often be treated with conservative techniques, although they tend to eventually recur. Currently, no single treatment exists that is efficient, long-lasting, minimally invasive, and easy to administer. This article ...
Patiño-Navarrete Rafael R InstitutCavanilles de Biodiversitat i Biologia Evolutiva, Universitat de València, C/Catedràtic José Beltrán n° 2, Paterna 46980, - - 2014
Uric acid stored in the fat body of cockroaches is a nitrogen reservoir mobilized in times of scarcity. The discovery of urease in Blattabacterium cuenoti, the primary endosymbiont of cockroaches, suggests that the endosymbiont may participate in cockroach nitrogen economy. However, bacterial urease may only be one piece in the ...
Brown Christine M - - 2014
Autism Spectrum Disorder (ASD) has been associated with essential fatty acid (EFA) deficiencies, with some researchers theorising that dysregulation of phospholipid metabolism may form part of the biological basis for ASD. This pilot study compared observable signs of fatty acid status of 19 children with an ASD diagnosis to 23 ...
Wang Pengfei P Weldon School of Biomedical Engineering, Purdue University, West Lafayette, IN, 47907, - - 2014
Barcode-like (BC) nanopatterns from programmed self-assembly of nucleic acids (DNA and RNA) are reported. BC nanostructures are generated by the introduction of open spaces at selected sites to an otherwise closely packed, plain, rectangle nucleic acid nanostructure. This strategy is applied to nanostructures assembled from both origami approach and single ...
Sandström Anders G AG Applied Microbiology, Department of Chemistry, Lund University, PO Box 124, 221 00, Lund, - - 2014
Carboxylic acids are important bulk chemicals that can be used as building blocks for the production of polymers, as acidulants, preservatives and flavour compound or as precursors for the synthesis of pharmaceuticals. Today, their production mainly takes place through catalytic processing of petroleum-based precursors. An appealing alternative would be to ...
Dorović Jelena J Bioengineering Research and Development Center, 34000, Kragujevac, Republic of Serbia, - - 2014
The M05-2X/6-311++G(d,p) and B3LYP-D2/6-311++G(d,p) models are used to evaluate scavenging potency of gallic acid. The hydrogen atom transfer (HAT), sequential proton loss electron transfer (SPLET), and single electron transfer followed by proton transfer (SET-PT) mechanisms of gallic acid with some radicals ((•)OO(-), (•)OH, and CH3OO(•)) were investigated using the corresponding ...
Nishino Naoki N Graduate School of Environmental and Life Science, Okayama University, Okayama, - - 2014
As a forage source for total mixed ration (TMR) silage production, locally produced crop silage is now used in addition to imported hay. This type of TMR ensiling is regarded as a two-step fermentation process; hence, a survey was carried out to determine whether the bacteria in crop silage affect ...
Wang Xu-Sheng XS State Key Laboratory of Structural Chemistry, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, Fuzhou, Fujian 350002, China. ybhuang@fjirsm.ac.cn - - 2014
Highly dispersed Keggin-type phosphotungstic acid (H3PW12O40, PTA) encapsulated in the mesocages of amine-functionalized metal-organic frameworks MIL-101(Cr)-NH2 has been prepared by an anion-exchange method. PTA anions (PW12O40(3-)) are stabilized in the mesocages via the electrostatic interaction with amino groups of the MIL-101(Cr)-NH2. The obtained catalyst (denoted PTA@MIL-101(Cr)-NH2) exhibits high catalytic activity ...
Samanta Mousumi M Department of Chemical Sciences, Indian Institute of Science Education and Research (IISER) Kolkata, Mohanpur, WB 741246, India. - - 2014
Azobenzene-3,3'-dicarboxylic acid exists in photoisomerizable (E) and (Z)-forms. Deprotonation of the carboxylic acid groups from the (E)-form occurs simultaneously, whereas in the (Z)-form it occurs in a stepwise fashion. The mono anionic form of the (Z)-isomer acts as a glycosidase mimic that proceeds through a general acid-general base catalytic mechanism. ...
Yari Abdollah A Department of Chemistry, Faculty of Science, Lorestan University, 68137-17133, Khorramabad, Iran, - - 2014
Here, we are describing the study of the chemiluminescence arising from the reaction of bis (2,4,6-trichlorophenyl) oxalate (TCPO) system with new bis [N-(4-pyridyl)-p-toluene sulfonamide] palladium dichloride (BSPC) as a novel luminescent. The optimum concentrations of all reagents such as sodium salicylate (SS) as catalyst, hydrogen peroxide as oxidizing reagent and ...
Akita Hironaga H Applied Molecular Microbiology and Biomass Chemistry Bioscience and Biotechnology, Faculty of Agriculture, Kyushu University, 6-10-1 Hakozaki, Higashi-ku, Fukuoka, 812-8581, Japan, - - 2014
D-isoleucine (D-Ile) can be assayed using chiral chromatography but the availability of that method is limited by the necessity for special expertise and expensive equipment. We therefore developed a simple and specific colorimetric assay system for D-Ile determination using an artificially created NADP(+)-dependent D-amino acid dehydrogenase (DAADH). The system consists ...
Worm Petra P Laboratory of Microbiology, Wageningen University, Dreijenplein 10, 6703 HB Wageningen, The Netherlands. Electronic address: - - 2014
In sulfate-reducing and methanogenic environments complex biopolymers are hydrolyzed and degraded by fermentative micro-organisms that produce hydrogen, carbon dioxide and short chain fatty acids. Degradation of short chain fatty acids can be coupled to methanogenesis or to sulfate-reduction. Here we study from a genome perspective why some of these micro-organisms ...
Brousseau-Foley Magali M a Université du Québec à Trois-Rivières, Sciences de l'activité - - 2014
Abstract Digital and interdigital corns are common painful foot conditions encountered by podiatrists during the course of their practice. These corns can often be treated using conservative techniques, although they tend to eventually reoccur. Currently, no single treatment exists that is efficient, long-lasting, minimally invasive, and easy to administer. This ...
Pavlickova Aimova Petra P Department of Biological and Medical Sciences, Faculty of Pharmacy in Hradec Kralove, Charles University in Prague, Hradec Kralove, Czech - - 2014
Normal adults require twenty L-amino acids (AA) for protein synthesis. Functional AA regulate key metabolic pathways that are necessary for maintenance, growth, reproduction and immunity. Dietary supplementation with one or a mixture of these AA may be beneficial for ameliorating health problems at various stages of the life cycle and ...
Zhang Liangxiao L Oil Crops Research Institute, Chinese Academy of Agricultural Sciences, Wuhan 430062, China; Key Laboratory of Biology and Genetic Improvement of Oil Crops, Ministry of Agriculture, Wuhan 430062, China; Laboratory of Risk Assessment for Oilseeds Products (Wuhan), Ministry of Agriculture, Wuhan 430062, China. Electronic address: - - 2014
Fatty acids are potential biomarkers of some diseases and also key markers and quality parameters of different dietary fats and related products. Thus, untargeted fatty acid profiles are important in the study of dietary fat quality and fat-related diseases, as well as in other fields such as bioenergy. In addition, ...
Nisbet Mark A - - 2014
Many fermentation volatiles important to wine aroma potentially arise from yeast metabolism of hexose sugars, but assessing the relative importance of these pathways is challenging due to high endogenous hexose substrate concentrations. To overcome this problem, gas chromatography combustion isotope ratio mass spectrometry (GC-C-IRMS) was used to measure high precision ...
Marcellin Esteban E Australian Institute for Bioengineering and Nanotechnology (AIBN), The University of Queensland, Brisbane, 4072, QLD, Australia, - - 2014
Hyaluronic acid (HA) is a ubiquitous polysaccharide found in humans, animals, bacteria, algae and molluscs. Simple yet sophisticated, HA demonstrates unique and valuable rheological properties. In solution, HA behaves as a stiffened random coil and the resultant behaviour, even at low concentrations, is far from Newtonian or 'ideal'. These rheological ...
Xu Yongqian Y College of Science, Northwest A&F University, Yangling, 712100, P. R. China. xuyq@nwsuaf.edu.cn - - 2014
A dual-channel including a colorimetric and fluorescent probe based on the aggregation-caused quenching (ACQ) and enzymolysis approach has been presented to screen acid phosphatase (ACP) and its inhibitor. Moreover, the ACP activity was determined by real time assay.
Monaco Mattia Riccardo MR Max-Planck-Institut für Kohlenforschung, Kaiser -Wilhelm-Platz 1, 45470 Mülheim an der Ruhr - - 2014
The hydrolytic ring opening of epoxides is an important biosynthetic transformation and is also applied industrially. We report the first organocatalytic variant of this reaction, exploiting our recently discovered activation of carboxylic acids with chiral phosphoric acids via heterodimerization. The methodology mimics the enzymatic mechanism, which involves an enzyme-bound carboxylate ...
Boga Carla C Department of Industrial Chemistry, "Toso Montanari", Alma Mater Studiorum- University of Bologna, Viale del Risorgimento 4, 40136, Bologna, - - 2014
Formaldehyde is an effective and popular semi-permanent hair straightener but the severe consequences for human health due to its toxicity have prompted the search for safer alternatives. Different carbonyl compounds, including glyoxylic acid, have recently been proposed as promising candidates. Despite the interest in this topic, there is a lack ...
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