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Singh Priyanka P Medicinal and Process Chemistry Division, CSIR-Central Drug Research Institute, B.S. 10/1, Jankipuram Extension, Sitapur Road, Lucknow 226031, India. gautam.panda@gmail.com - - 2014
As a result of their easy availability in enantiomerically enriched form and their possession of synthetically transformable diverse functional groups, amino acids have been extensively used by synthetic organic and medicinal chemists as a chiral pool for access to heterocycles (monocycles, bicycles or polycycles, either bridged or fused). This review ...
Cuadri A A AA Departamento de Ingeniería Química, Centro de Investigación en Tecnología de Productos y Procesos Químicos (Pro(2) TecS), Campus de 'El Carmen', Universidad de Huelva, 21071 Huelva, - - 2014
The accumulation of phosphogypsum waste from the fertilizer industries, which remain in regulated stacks occupying considerable land resources, is causing significant environment problems worldwide. In that sense, the scientific community is being pressured to find alternative ways for their disposal. In this research, we propose a novel application for phosphogypsum ...
Gao Xu X Key Laboratory for Environmentally Friendly Chemistry and Application of the Ministry of Education, College of Chemistry, Xiangtan University , Hunan 411105, - - 2014
A practical Brønsted acid promoted benzylic C-H functionalization of 2-alkylazaarenes and nucleophilic addition to nitroso compounds was developed under mild conditions. Switched by Brønsted acids, this method can afford azaarene-2-aldimines, azaarene-2-carbaldehyde, or azaarene-2-oximes selectively. No metal, base, oxidant, or other additives were required.
Buter Jeffrey J Statingh Institute for Chemistry, University of Groningen, Nijenborgh 7, 9747 AG Groningen, The Netherlands. - - 2014
The palladium-catalyzed conjugate addition (Michael addition) of ortho-substituted arylboronic acids to β,β-disubstituted cyclic enones, in particular 3-methyl cyclopent-2-enone and 3-methyl cyclohex-2-enone, is reported. With an achiral bipyridine-based palladium catalyst, good yields are obtained with a variety of ortho-substituted arylboronic acids. In the asymmetric version, good to very high enantiomeric excesses ...
Constable Peter D PD College of Veterinary Medicine, University of Illinois at Urbana-Champaign, 2001 South Lincoln Avenue, Urbana, IL 61802, USA. Electronic address: - - 2014
The Henderson-Hasselbalch equation is probably the most famous equation in biology but is more descriptive than mechanistic. The traditional approach to acid-base assessment using the Henderson-Hasselbalch equation provides a clinically useful and accurate method when plasma protein concentrations are within the reference range. The simplified strong ion approach is a ...
Shariatifar Nabi N Department of Environment Health, School of Public Health, Tehran University of Medical Sciences (TUMS), Tehran, - - 2014
The essential oil from aerial parts of Pulicaria gnaphalodes was studied in soybean oil. The aim of this study was to evaluate the antioxidant activitiey of Iranian Pulicaria gnaphalodes essential oil in soybean oil during the storage period. The essential oil obtained from Pulicaria gnaphalodes by hydrodistillation and analyzed by ...
Wang Pengfei P Weldon School of Biomedical Engineering, Purdue University, West Lafayette, IN, 47907, - - 2014
Barcode-like (BC) nanopatterns from programmed self-assembly of nucleic acids (DNA and RNA) are reported. BC nanostructures are generated by the introduction of open spaces at selected sites to an otherwise closely packed, plain, rectangle nucleic acid nanostructure. This strategy is applied to nanostructures assembled from both origami approach and single ...
Sandström Anders G AG Applied Microbiology, Department of Chemistry, Lund University, PO Box 124, 221 00, Lund, - - 2014
Carboxylic acids are important bulk chemicals that can be used as building blocks for the production of polymers, as acidulants, preservatives and flavour compound or as precursors for the synthesis of pharmaceuticals. Today, their production mainly takes place through catalytic processing of petroleum-based precursors. An appealing alternative would be to ...
Dorović Jelena J Bioengineering Research and Development Center, 34000, Kragujevac, Republic of Serbia, - - 2014
The M05-2X/6-311++G(d,p) and B3LYP-D2/6-311++G(d,p) models are used to evaluate scavenging potency of gallic acid. The hydrogen atom transfer (HAT), sequential proton loss electron transfer (SPLET), and single electron transfer followed by proton transfer (SET-PT) mechanisms of gallic acid with some radicals ((•)OO(-), (•)OH, and CH3OO(•)) were investigated using the corresponding ...
Nishino Naoki N Graduate School of Environmental and Life Science, Okayama University, Okayama, - - 2014
As a forage source for total mixed ration (TMR) silage production, locally produced crop silage is now used in addition to imported hay. This type of TMR ensiling is regarded as a two-step fermentation process; hence, a survey was carried out to determine whether the bacteria in crop silage affect ...
Wang Xu-Sheng XS State Key Laboratory of Structural Chemistry, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, Fuzhou, Fujian 350002, China. ybhuang@fjirsm.ac.cn - - 2014
Highly dispersed Keggin-type phosphotungstic acid (H3PW12O40, PTA) encapsulated in the mesocages of amine-functionalized metal-organic frameworks MIL-101(Cr)-NH2 has been prepared by an anion-exchange method. PTA anions (PW12O40(3-)) are stabilized in the mesocages via the electrostatic interaction with amino groups of the MIL-101(Cr)-NH2. The obtained catalyst (denoted PTA@MIL-101(Cr)-NH2) exhibits high catalytic activity ...
Samanta Mousumi M Department of Chemical Sciences, Indian Institute of Science Education and Research (IISER) Kolkata, Mohanpur, WB 741246, India. - - 2014
Azobenzene-3,3'-dicarboxylic acid exists in photoisomerizable (E) and (Z)-forms. Deprotonation of the carboxylic acid groups from the (E)-form occurs simultaneously, whereas in the (Z)-form it occurs in a stepwise fashion. The mono anionic form of the (Z)-isomer acts as a glycosidase mimic that proceeds through a general acid-general base catalytic mechanism. ...
Yari Abdollah A Department of Chemistry, Faculty of Science, Lorestan University, 68137-17133, Khorramabad, Iran, - - 2014
Here, we are describing the study of the chemiluminescence arising from the reaction of bis (2,4,6-trichlorophenyl) oxalate (TCPO) system with new bis [N-(4-pyridyl)-p-toluene sulfonamide] palladium dichloride (BSPC) as a novel luminescent. The optimum concentrations of all reagents such as sodium salicylate (SS) as catalyst, hydrogen peroxide as oxidizing reagent and ...
Akita Hironaga H Applied Molecular Microbiology and Biomass Chemistry Bioscience and Biotechnology, Faculty of Agriculture, Kyushu University, 6-10-1 Hakozaki, Higashi-ku, Fukuoka, 812-8581, Japan, - - 2014
D-isoleucine (D-Ile) can be assayed using chiral chromatography but the availability of that method is limited by the necessity for special expertise and expensive equipment. We therefore developed a simple and specific colorimetric assay system for D-Ile determination using an artificially created NADP(+)-dependent D-amino acid dehydrogenase (DAADH). The system consists ...
Worm Petra P Laboratory of Microbiology, Wageningen University, Dreijenplein 10, 6703 HB Wageningen, The Netherlands. Electronic address: - - 2014
In sulfate-reducing and methanogenic environments complex biopolymers are hydrolyzed and degraded by fermentative micro-organisms that produce hydrogen, carbon dioxide and short chain fatty acids. Degradation of short chain fatty acids can be coupled to methanogenesis or to sulfate-reduction. Here we study from a genome perspective why some of these micro-organisms ...
Brousseau-Foley Magali M a Université du Québec à Trois-Rivières, Sciences de l'activité - - 2014
Abstract Digital and interdigital corns are common painful foot conditions encountered by podiatrists during the course of their practice. These corns can often be treated using conservative techniques, although they tend to eventually reoccur. Currently, no single treatment exists that is efficient, long-lasting, minimally invasive, and easy to administer. This ...
Pavlickova Aimova Petra P Department of Biological and Medical Sciences, Faculty of Pharmacy in Hradec Kralove, Charles University in Prague, Hradec Kralove, Czech - - 2014
Normal adults require twenty L-amino acids (AA) for protein synthesis. Functional AA regulate key metabolic pathways that are necessary for maintenance, growth, reproduction and immunity. Dietary supplementation with one or a mixture of these AA may be beneficial for ameliorating health problems at various stages of the life cycle and ...
Nisbet Mark A - - 2014
Many fermentation volatiles important to wine aroma potentially arise from yeast metabolism of hexose sugars, but assessing the relative importance of these pathways is challenging due to high endogenous hexose substrate concentrations. To overcome this problem, gas chromatography combustion isotope ratio mass spectrometry (GC-C-IRMS) was used to measure high precision ...
Marcellin Esteban E Australian Institute for Bioengineering and Nanotechnology (AIBN), The University of Queensland, Brisbane, 4072, QLD, Australia, - - 2014
Hyaluronic acid (HA) is a ubiquitous polysaccharide found in humans, animals, bacteria, algae and molluscs. Simple yet sophisticated, HA demonstrates unique and valuable rheological properties. In solution, HA behaves as a stiffened random coil and the resultant behaviour, even at low concentrations, is far from Newtonian or 'ideal'. These rheological ...
Xu Yongqian Y College of Science, Northwest A&F University, Yangling, 712100, P. R. China. xuyq@nwsuaf.edu.cn - - 2014
A dual-channel including a colorimetric and fluorescent probe based on the aggregation-caused quenching (ACQ) and enzymolysis approach has been presented to screen acid phosphatase (ACP) and its inhibitor. Moreover, the ACP activity was determined by real time assay.
Monaco Mattia Riccardo MR Max-Planck-Institut für Kohlenforschung, Kaiser -Wilhelm-Platz 1, 45470 Mülheim an der Ruhr - - 2014
The hydrolytic ring opening of epoxides is an important biosynthetic transformation and is also applied industrially. We report the first organocatalytic variant of this reaction, exploiting our recently discovered activation of carboxylic acids with chiral phosphoric acids via heterodimerization. The methodology mimics the enzymatic mechanism, which involves an enzyme-bound carboxylate ...
Boga Carla C Department of Industrial Chemistry, "Toso Montanari", Alma Mater Studiorum- University of Bologna, Viale del Risorgimento 4, 40136, Bologna, - - 2014
Formaldehyde is an effective and popular semi-permanent hair straightener but the severe consequences for human health due to its toxicity have prompted the search for safer alternatives. Different carbonyl compounds, including glyoxylic acid, have recently been proposed as promising candidates. Despite the interest in this topic, there is a lack ...
Onaka Takuya - - 2014
A mild and regioselective 2-arylation of 5-substituted tetrazoles is described. The reaction proceeds regioselectively with a variety of arylboronic acids in the presence of [Cu(OH)(TMEDA)]2Cl2 to afford 2,5-disubstituted tetrazoles. This is the first report of highly regioselective arylation of 5-alkyltetrazoles.
Baiocchi Claudio C Molecular Biotechnology and Health Sciences Department, University of Torino, Via P. Giuria 5, 10125 Torino, - - 2015
Natural sources of triacylglycerols containing ω-3 fatty acids are of particular interest due to their protective role against several human diseases. However, as it has been well ascertained, the position of the ω-3 fatty acid on the triacylglycerol backbone influences how digestion occurs. In particular, occurrence at the sn-2 position ...
Su Erzheng - - 2014
In this work, the low cost naturally immobilized Carica papaya lipase (CPL) was investigated for fatty acid butyl esters (FABE) production to fulfil the aim of reducing the lipase cost in enzymatic butyl-biodiesel process. The CPL showed specificities to different alcohol acyl acceptors. Alcohols with more than three carbon atoms ...
Han Junbin J Department of Chemistry, University of Louisville , Louisville, Kentucky 40292, United - - 2014
Brønsted or Lewis acid assisted activation of an imidogold precatalyst (L-Au-Pht, Pht = phthalimide) offers a superior way to generate cationic gold compared with the commonly used silver-based system. It is also broadly applicable for most common gold-catalyzed reactions. For reactions that require milder conditions, milder acids can be used ...
Bhattacherjee Abhishek A a Department of Botany , Presidency University , 86/1, College Street, Kolkata 700 073 , West Bengal - - 2014
Alternanthera philoxeroides (Mart.) is a tropical weed commonly known as alligator weed. It grows rapidly within a small span of time and easily available all over the world. The objective of this work was to isolate and characterise the major phenolic components present in the methanol-soluble fraction (fraction X) of ...
Boto-Ordóñez María M Biomarkers and Nutritional & Food Metabolomics Research Group, Nutrition and Food Science Department, XaRTA, INSA, Pharmacy Faculty, University of Barcelona, Avenida Joan XXIII s/n, 08028 Barcelona, Spain. - - 2014
The health benefits associated with the consumption of polyphenol-rich foods have been studied in depth, however, the full mechanism of action remains unknown. One of the proposed mechanisms is through microbiota interaction. In the present study, we aimed to explore the relationship between changes in fecal microbiota and changes in ...
Laidlaw Maggie - - 2014
Omega-3 fatty acids confer beneficial health effects, but North Americans are lacking in their dietary omega-3-rich intake. Supplementation is an alternative to consumption of fish; however, not all omega-3 products are created equal. The trial objective was to compare the increases in blood levels of omega-3 fatty acids after consumption ...
Colombo Stefano S University of Copenhagen, Department of Pharmacy, Faculty of Health and Medical Sciences , Universitetsparken 2, Copenhagen, 2100-DK , Denmark +45 35 33 64 02 ; - - 2014
Introduction: Nucleic acids have witnessed a dramatic acceleration in their therapeutic exploitation and currently represent a growing number of applications in drug development pipelines. However, a more wide-spread development of therapeutics based on nucleic acids is restricted by their poor chemical and enzymatic stability in vivo, lack of cellular uptake ...
Kula Józef J Institute of General Food Chemistry, Lodz University of Technology, Lodz 90-924, Poland. Electronic address: - - 2014
(R)-Ricinoleic acid methyl ester obtained from commercial castor oil was transformed in a three-step procedure into its S-enantiomer in overall 36% yield using ionic liquid (1-butyl-3-methylimidazolium acetate) in the key step process. The developed procedure provides easy access to (S)-ricinoleic acid and its methyl ester of over 95% enantiomeric excess. ...
Schneider Manuella M Industrial Chemistry Course, Universidade de Santa Cruz do Sul, Santa Cruz do Sul, Brasil - - 2014
In this study, we propose the use of tung cake for the production of organic acids, with an emphasis on citric acid by solid-state fermentation. We evaluated the conditions of production and the by-products from the biodiesel chain as raw materials involved in this bioprocess. First, we standardized the conditions ...
De Roo Jonathan - - 2014
We synthesized HfO2 nanocrystals from HfCl4 using a surfactant-free solvothermal process in benzylalcohol and found that the resulting nanocrystals could be transferred to nonpolar media using a mixture of carboxylic acids and amines. Using solution 1H NMR and elemental analysis, we studied the details of the transfer reaction and the ...
Nosova Emily V EV Department of Surgery, University of California, San Francisco, San Francisco, Calif; VIPERx Laboratory, San Francisco, - - 2014
Despite available medical therapies, patients with peripheral arterial disease (PAD) remain at high risk for cardiovascular events. The n-3 polyunsaturated fatty acids (PUFA), derived from marine sources, have been shown to improve cardiovascular mortality. The Omega-3 Index (O3I), a proportion of the n-3 PUFA eicosapentaenoic acid and docosahexaenoic acid in ...
Lesma G G a Dipartimento di Chimica , Università degli Studi di Milano , via C. Golgi 19, 20133 Milano , - - 2014
Within a project aimed to reintroduce non-drug hemp cultivars in the Italian Po valley, for fibre but also high added-value nutraceutical production, investigation on locally grown plants has been performed, in order to assess their oil and metabolic content. This study provides useful information regarding three different hemp cultivars, from ...
Labrenz Steven R SR Parenterals and Liquids, Drug Product Development, PDMS, Janssen R&D LLC, Malvern, Pennsylvania, - - 2014
An observation of visible particulate matter was made during formulation development of a mAb and investigations initiated to understand the colloidal instability of the formulation. It was observed that there was a loss of polysorbate in the IgG formulation and concurrent hydrolysis of polysorbate 80 (PS80) into fatty acid, polyethylene ...
Dhamankar Himanshu H Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139; Synthetic Biology Engineering Research Center (SynBERC), Massachusetts Institute of Technology, Cambridge, MA - - 2014
3-hydroxy-γ-butyrolactone (3HBL) is a versatile chiral synthon, deemed a top value-added chemical from biomass by the DOE. We recently reported the first biosynthetic pathway towards 3HBL and its hydrolyzed form, 3,4-dihydroxybutyric acid (3,4-DHBA) in recombinant Escherichia coli using glucose and glycolic acid as feedstocks and briefly described their synthesis solely ...
Hammami Hossein - - 2014
The photodecomposition of herbicides can be affectedvia adding vegetable oils to spray tank. Nine vegetable oils were compared to assess the photodecomposition of sethoxydim under natural light conditions. The experiment was conducted as completely randomized factorial design with three replications at the College of Agriculture, Ferdowsi University of Mashhad, Iran, ...
Kaura Mamta - - 2014
Conformationally restricted nucleotides such as locked nucleic acids (LNAs) are very popular as affinity-, specificity- and stability-enhancing modifications in oligonucleotide chemistry to produce probes for nucleic acid targeting applications in molecular biology, biotechnology and medicinal chemistry. Considerable efforts have been devoted in recent years to optimize LNA's biophysical properties through ...
Cvetesic Nevena N Department of Chemistry, Faculty of Science University of Zagreb, Zagreb, - - 2014
The fidelity of protein synthesis depends on the capacity of aminoacyl-tRNA synthetases (AARSs) to couple only cognate amino acid-tRNA pairs. If amino acid selectivity is compromised, fidelity can be ensured by an inherent AARS editing activity that hydrolyses mischarged tRNAs. Here, we show that the editing activity of Escherichia coli ...
Maria Daglia - - 2014
Gallic acid (3,4,5-trihydroxybenzoic acid) is a phenolic acid widely distributed in many different families of higher plants, both in free state, and as a part of more complex molecules, such as ester derivatives or polymers. In nature, gallic acid and its derivatives are present in nearly every part of the ...
Fan Gang G College of Ethnic Medicine, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, - - 2014
Swertia mussotii Franch. and Swertia chirayita Buch.-Ham. have been commonly used under the same name "Zangyinchen" for the treatment of liver and gallbladder diseases in traditional Tibetan medicine. Detailed characterization and comparison of the complete set of metabolites of these two species are critical for their objective identification and quality ...
Lin Keying K State Key Laboratory Cultivation Base of Natural Gas Conversion, College of Chemistry, Ningxia University, Yinchuan 750021, - - 2014
Liquid sulphuric acid is adopted and compared with carbon-based sulfonated solid acids (coal tar-based and active carbon-based) for furfural residues conversion into reducing sugars. The optimum hydrolysis conditions of liquid acid are at 4% of sulphuric acid, 25:1 of liquid and solid ratio, 175°C of reaction temperature and 120min of ...
Groninger-Poe Fiona P - - 2014
The genome of Agrobacterium tumefaciens C58 encodes twelve members of the enolase superfamily (ENS), eight of which are members of the mandelate racemase (MR) subgroup and, therefore, likely to be acid sugar dehydratases. Using a library of 77 acid sugars for high throughput screening, one protein (UniProt accession ID A9CG74; ...
Kudo Fumitaka F Department of Chemistry, Tokyo Institute of Technology, 2-12-1, O-okayama, Meguro-ku, Tokyo 152-8551, Japan. - - 2014
Covering: up to January, 2014We focus here on β-amino acids as components of complex natural products because the presence of β-amino acids produces structural diversity in natural products and provides characteristic architectures beyond those of ordinary α-l-amino acids, thus generating significant and unique biological functions in nature. In this review, ...
Gatter Michael M Institute of Microbiology, Dresden University of Technology, Zellescher Weg 20b, 01217, - - 2014
Nine potential (fatty) alcohol dehydrogenase genes and one alcohol oxidase gene were identified in Yarrowia lipolytica by comparative sequence analysis. All relevant genes were deleted in Y. lipolytica H222ΔP which is lacking β-oxidation. Resulting transformants were tested for their ability to accumulate ω-hydroxy fatty acids and dicarboxylic acids in the ...
Di Giulio Massimo M Early Evolution of Life Laboratory, Institute of Biosciences and Bioresources, CNR, Via P. Castellino, 111, 80131, Naples, Italy, - - 2014
The phylogenetic analyses as far as the identification of the number of domains of life is concerned have not reached a clear conclusion. In the attempt to improve this circumstance, I introduce the concept that the amino acids codified in the genetic code might be of markers with outstanding phylogenetic ...
Liu Changyong C Biomanufacturing Engineering Laboratory, Graduate School at Shenzhen, Tsinghua University, Shenzhen, - - 2014
Scaffolds are of great importance to the success of tissue engineering. Poly(l-lactide-co-glycolide) acid is one of the most commonly used biopolymers. This study develops a novel low-temperature deposition machine using screw extrusion to fabricate poly(l-lactide-co-glycolide) acid scaffolds. The screw extrusion process of poly(l-lactide-co-glycolide) acid is analysed, and the relationship between ...
Evans Simon J SJ Department of Psychiatry, University of Michigan, United States. Electronic address: - - 2014
Polyunsaturated fatty acids (PUFA) profiles associate with risk for mood disorders. This poses the hypothesis of metabolic differences between patients and unaffected healthy controls that relate to the primary illness or are secondary to medication use or dietary intake. However, dietary manipulation or supplementation studies show equivocal results improving mental ...
Kim Soomin S Department of Chemistry and Nano Science, Ewha Global Top 5 Program, Ewha Womans University, Seoul 120-750, Korea. - - 2014
The terminal amino groups of peptoids have often been protected with acetyl groups to improve cell permeability and therapeutic potential, and to prevent the poisoning of the catalysts in organometallic reactions. Interestingly, the unusual truncation of the terminal peptoid unit has sometimes been encountered when the acetylated linear peptoids were ...
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