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Jambunathan Pooja P Department of Chemical Engineering and Materials Science, University of Minnesota, Twin Cities, MN 55455, - - 2014
Since traditional chemical processes are non-renewable and environmentally unfriendly, biosynthesis is emerging as an attractive alternative for the production of advanced biofuels, chemicals, pharmaceuticals and polymers. Cost-competitive biomanufacturing requires the design of metabolic pathways that can achieve high production yields and rates. Recent advances in natural amino acid production have ...
Kaulmann Anouk A Centre de Recherche Public - Gabriel Lippmann, Environment and Agro-biotechnologies Department, L-4422 Belvaux, - - 2014
The consumption of phytochemicals such as carotenoids and polyphenols within whole fruits and vegetables has been associated with decreased incidence of various inflammation and oxidative stress related chronic diseases, which may be due to direct antioxidant effects, or indirect mechanisms such as affecting signal transduction/gene expression. Within the present study, ...
Rit Raja K RK School of Chemistry, University of Hyderabad , Hyderabad-500046, - - 2014
Pd(II)-catalyzed ortho-C-H acetoxylation of arylacetic acid derivatives is demonstrated with the aid of a novel S-methyl-S-2-pyridylsulfoximine (MPyS) directing group (DG). The α-mono- and α-unsubstituted arylacetic acid derivatives were readily employed in the ortho-C-H acetoxylations. The oxidation products are hydrolyzed, and the MPyS-DG is easily recovered, providing ready access to o-hydroxyarylacetic ...
Tee Ting Wei TW Department of Chemical and Biological Engineering, Iowa State University, Ames, - - 2014
Increasing demand for petroleum has stimulated industry to develop sustainable production of chemicals and biofuels using microbial cell factories. Fatty acids of chain lengths from C6 to C16 are propitious intermediates for the catalytic synthesis of industrial chemicals and diesel-like biofuels. The abundance of genetic information available for Escherichia coli ...
Eddleston Mark D MD Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW, United - - 2014
The dissociation at high humidity of cocrystals formed between caffeine and theophylline with a series of dicarboxylic acids is investigated and found to be driven by the partial dissolution of the acid, rather than by the formation of caffeine/theophylline hydrate. It is shown that partial dissociation occurs under all humidity ...
Thyparambil Aby A AA Department of Bioengineering, 501 Rhodes Engineering Research Center, Clemson University, Clemson, SC - - 2014
The labeling of amino acid residues followed by peptide mapping via mass spectrometry (AAL/MS) is a promising technique to provide detailed information on the adsorption-induced changes in its solvent accessibility. However, the potential of this method for the study of adsorbed protein structure is largely undeveloped at this time. The ...
Miyoshi Yurika Y Graduate School of Pharmaceutical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, - - 2014
Enantioselective amino acid metabolome analysis of the Japanese traditional black vinegars (amber rice vinegar, Kurozu) was performed using two-dimensional high-performance liquid chromatography combining a microbore-monolithic ODS column and narrowbore-enantioselective columns. d-Amino acids, the enantiomers of widely observed l-amino acids, are currently paid attention as novel physiologically active substances, and the ...
Mascal Mark M Department of Chemistry, University of California Davis, 1 Shields Avenue, Davis, CA 95616 (USA). - - 2014
Dehydration of biomass-derived levulinic acid under solid acid catalysis and treatment of the resulting angelica lactone with catalytic K2 CO3 produces the angelica lactone dimer in excellent yield. This dimer serves as a novel feedstock for hydrodeoxygenation, which proceeds under relatively mild conditions with a combination of oxophilic metal and ...
Kim Moon-Il - - 2014
A cell-based assay system for simultaneous quantification of the three amino acids, phenylalanine (Phe), methionine (Met), and leucine (Leu) in a single biological sample, was developed and applied in the multiplex diagnosis of three key metabolic diseases of newborn babies. The assay utilizes three E. coli auxotrophs, which grow only ...
Shanmugam Muthu K MK Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, - - 2014
Oleanolic acid (OA, 3β-hydroxyolean-12-en-28-oic acid) is a ubiquitous pentacyclic multifunctional triterpenoid, widely found in several dietary and medicinal plants. Natural and synthetic OA derivatives can modulate multiple signaling pathways including nuclear factor-κB, AKT, signal transducer and activator of transcription 3, mammalian target of rapamycin, caspases, intercellular adhesion molecule 1, vascular ...
Teng Kim-Tiu - - 2014
Obesity plays a pivotal role in the development of low-grade inflammation. Dietary fatty acids are important modulators of inflammatory responses. Saturated fatty acids (SFA) and n-6 polyunsaturated fatty acids (PUFA) have been reported to exert pro-inflammatory effects. n-3 PUFA in particular, possess anti-inflammatory properties. Numerous clinical studies have been conducted ...
Wolters Lando P LP Department of Theoretical Chemistry, Amsterdam Center for Multiscale Modeling, VU University Amsterdam De Boelelaan 1083, 1081 HV Amsterdam (The - - 2014
Our purpose is to understand the mechanism through which pH affects the competition between base-induced elimination and substitution. To this end, we have quantum chemically investigated the competition between elimination and substitution pathways in H2O+C2H5OH2 (+) and OH(-)+C2H5OH, that is, two related model systems that represent, in a generic manner, ...
Roche Stéphane P SP Department of Chemistry and Biochemistry, Florida Atlantic University, 777 Glades Road, Boca Raton, FL 33431, USA. - - 2014
A novel acetyl chloride-mediated cascade transformation involving three components (benzyl carbamate, ethyl glyoxylate and arene nucleophiles) is reported. Aryl orthogonally protected α-amino acids are obtained in a one pot cascade, using a mild AcOH-AcCl system, via a critical autocatalytic dehydration-activation step ensuring an original and efficient Friedel-Crafts orchestration.
Peluso Ilaria I Department of Physiology and Pharmacology "V. Erspamer", "Sapienza" University of Rome , Rome , - - 2014
Abstract The metabolic syndrome can be prevented by the Mediterranean diet, characterized by fiber, omega-3 polyunsaturated fatty acids and polyphenols. However, the composition of the Mediterranean diet, which can be viewed as a natural multiple supplement, is poorly controlled, and its beneficial effects poorly predictable. The metabolic syndrome is associated ...
Dimitrijević Elena E Department of Chemistry, University of Toronto, 80 St. George St., Toronto, ON M5S 3H6, Canada. - - 2014
Two-fold Suzuki-Miyaura cross-couplings of cyclic diarylborinic acids are described. This novel annulation method enables the synthesis of benzo-fused heterocycles from dihaloarenes or gem-dibromoolefins.
Dan Nily N Department of Chemical and Biological Engineering, Drexel University, Philadelphia, PA 19104, USA. Electronic address: - - 2014
The structure and function of lipid-based complexes (lipoplexes) have been widely investigated as cellular delivery vehicles for nucleic acids-DNA and siRNA. Transfection efficiency in applications such as gene therapy and gene silencing has been clearly linked to the local, nano-scale organization of the nucleic acid in the vehicle, as well ...
Nagendiran Anuja A Department of Organic Chemistry, Arrhenius Laboratory, Stockholm University , SE-106 91 Stockholm, - - 2014
Cycloisomerization of various γ-acetylenic acids to their corresponding γ-alkylidene lactones by the use of a heterogeneous Pd(II) catalyst supported on amino-functionalized siliceous mesocellular foam is described. Substrates containing terminal as well as internal alkynes were cyclized in high to excellent yields within 2-24 h under mild reaction conditions. The protocol ...
Kawata Yoshikazu Y Health Research Institute, National Institute of Advanced Industrial Science and Technology (AIST), 1-8-31 Midorigaoka, Ikeda, Osaka 563-8577, Japan. Electronic address: - - 2014
To establish a sustainable society, commodity chemicals need to be developed from biomass resources. Recently, (R)-3-hydroxybutyric acid ((R)-3-HB), a monomer of bioplastic poly-(R)-3-hydroxybutyric acid (PHB), has attracted attention for its possible use in the chemical industry. Halophilic bacteria have been considered for bioprocess applications due to certain characteristics such as ...
Espinosa-Gonzalez Isabel I Biorefining Conversions and Fermentations Laboratory, Department of Agricultural, Food and Nutritional Science, 4-10 Agriculture/Forestry Centre, University of Alberta, Edmonton, AB T6G 2P5, - - 2014
The aim of this study was to evaluate the conversion of microalgal biomass to renewable chemicals and fuels through a two-step reaction and separation process. High density Chlorella protothecoides culture with 40% lipid accumulation (dwb) was produced in 10L bioreactors and hydrolyzed in batch stainless steel reactors under subcritical conditions. ...
Luna-Palencia Gabriela R - - 2014
Valproic acid (VPA) is extensively used as an anticonvulsive agent and as a treatment for other neurological disorders. It has been shown that VPA exerts an anti-proliferative effect on several types of cancer cells by inhibiting the activity of histone deacetylases (HDACs), which are involved in replication and differentiation processes. ...
Snelders Jeroen J Laboratory of Food Chemistry and Biochemistry & Leuven Food Science and Nutrition Research Centre (LFoRCe), KU Leuven, Kasteelpark Arenberg 20, 3001 Leuven, - - 2014
To assess the potential of acetic and formic acid organosolv fractionation of wheat straw as basis of an integral biorefinery concept, detailed knowledge on yield, composition and purity of the obtained streams is needed. Therefore, the process was performed, all fractions extensively characterized and the mass balance studied. Cellulose pulp ...
Madan Raman K RK Beth Israel Medical Center, Mount Sinai Health System; Department of Dermatology, Icahn School of Medicine at Mount - - 2014
Topical salicylic acid is often used in dermatologic conditions because of its keratolytic, bacteriostatic, fungicidal, and photoprotective properties. The bioavailability of salicylic acid differs depending on the vehicle used and pH of transcellular fluids. Although rare, salicylic acid toxicity (salicylism) can occur from topical application. Physicians should be mindful of ...
Seon Jiyun J The Institute of Cleaner Production, Pukyong National University, 365 Sinseon-ro, Nam-gu, Busan 608-739, Republic of Korea; Department of Civil and Environmental Engineering, Pusan National University, 63 Busandaehak-ro, Geumjeong-gu, Busan 609-735, Republic of - - 2014
Alginate as biomass feedstock for bioconversion into volatile fatty acids (VFAs) is limited primarily by the low solubility in water or little utilization as microbial substrate and yet unknown about the microbial community structure for acidogenesis. The bacterial community structure was demonstrated the reflected changes in VFAs profiles in the ...
Lee Hyungjae H 1 Department of Food Engineering, Dankook University , Cheonan, - - 2014
Abstract With the increasing concern for health and nutrition, dietary fat has attracted considerable attention. The composition of fatty acids in a diet is important since they are associated with major diseases, such as cancers, diabetes, and cardiovascular disease. The biosynthesis of unsaturated fatty acids (UFA) requires the expression of ...
Ma Ruoshui R Voiland School of Chemical Engineering and Bioengineering, Bioproducts, Science & Engineering Laboratory, Washington State University, 2710 Crimson Way, Richland, WA, 99354 - - 2014
The emerging biomass-to-biofuel conversion industry has created an urgent need for identifying new applications for biorefinery lignin. This paper demonstrates a new route to producing dicarboxylic acids from biorefinery lignin through chalcopyrite-catalyzed oxidation in a highly selective process. Up to 95 % selectivity towards stable dicarboxylic acids was obtained for several ...
Zhao Yingjie Y Department of Organic Chemistry, University of Geneva , Geneva, - - 2014
The introduction of new noncovalent interactions to build functional systems is of fundamental importance. We here report experimental and theoretical evidence that anion-π interactions can contribute to catalysis. The Kemp elimination is used as a classical tool to discover conceptually innovative catalysts for reactions with anionic transition states. For anion-π ...
Jirošová Anna A Institute of Organic Chemistry and Biochemistry, Flemingovo n. 2, 166 10 Prague (Czech - - 2014
In 1974, (E)-1-nitropentadec-1-ene, a strong lipophilic contact poison of soldiers of the termite genus Prorhinotermes, was the first-described insect-produced nitro compound. However, its biosynthesis remained unknown. In the present study, we tested the hypothesis that (E)-1-nitropentadec-1-ene biosynthesis originates with condensation of amino acids with tetradecanoic acid. By using in vivo ...
Nakatani Akihiro - - 2014
A manganese-mediated dehydrogenative direct alkylation of 2-pyridones with diethyl malonates has been developed. A similar reaction system is applicable to the direct arylation with arylboronic acids. These manganese-based reactions occur regioselectively at the C3 position of the 2-pyridones. The observed high C3-regioselectivity can complement precedented C-H functionalization protocols of the ...
Crisóstomo Fernando Pinacho FP Instituto de Productos Naturales y Agrobiología, CSIC, Francisco Sánchez, 3, 38206 La Laguna, Tenerife - - 2014
Ascorbic acid (vitamin C) has been used as a radical initiator in a metal-free direct CH arylation of (hetero)arenes. Starting from an aniline, the corresponding arenediazonium ion is generated in situ and immediately reduced by vitamin C to an aryl radical that undergoes a homolytic aromatic substitution with a (hetero)arene. ...
Schulthess Bettina B Institute of Medical Microbiology, University of Zurich, Zurich, - - 2014
Reported MALDI-TOF MS identification rates of Gram-positive rods (GPR) are low compared to identification rates of Gram-positive cocci. In this study, three sample preparation methods were compared for MALDI-TOF MS identification of 190 well-characterized GPR strains: direct transfer, direct transfer-formic acid preparation, and ethanol-formic acid extraction. Using the interpretation criteria ...
Feng Zhang Z Key Laboratory of Organofluorine Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Lu, Shanghai 200032 - - 2014
The palladium-catalyzed difluoroalkylation of aryl boronic acids with bromodifluoromethylphosphonate, bromodifluoroacetate, and further derivatives has been developed. This method provides a facile and useful access to a series of functionalized difluoromethylated arenes (ArCF2 PO(OEt)2 , ArCF2 CO2 Et, and ArCF2 CONR(1) R(2) ) that have important applications in drug discovery and ...
Bradley Christina J CJ Department of Oceanography, University of Hawaii, Honolulu, Hawaii, United States of - - 2014
Compound specific isotopic analysis (CSIA) of amino acids has received increasing attention in ecological studies in recent years due to its ability to evaluate trophic positions and elucidate baseline nutrient sources. However, the incorporation rates of individual amino acids into protein and specific trophic discrimination factors (TDFs) are largely unknown, ...
Li Bi-Qing BQ Key Laboratory of Systems Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, P. R. - - 2014
Aptamers are oligonucleic acid or peptide molecules that bind to specific target molecules. As a novel and powerful class of ligands, aptamers are thought to have excellent potential for applications in the fields of biosensing, diagnostics and therapeutics. In this study, a new method for predicting aptamer-target interacting pairs was ...
Yang Yuanfa Y Key Laboratory of the Ministry of Education for Advanced Catalysis Materials, Zhejiang Normal University, 688 Yingbin Road, Jinhua 321004, China. - - 2014
An unprecedented Pd-catalyzed trans-addition of boronic acids to ynamides has been reported, giving α,β-disubstituted enamides in high yields with excellent regio- and stereoselectivity. A possible mechanism involving the palladium carbene intermediate has been proposed to account for the unusual trans-addition.
Prasad Manish M 1Department of Paediatric Neurology and Neurodisability, Dewsbury Hospital, Wakefield, United - - 2014
Late-onset glutaric aciduria type II has been described recently as a rare but treatable cause of proximal myopathy in teenagers and adults. It is an autosomal recessive disease affecting fatty acid, amino acid, and choline metabolism. This is usually a result of 2 defective flavoproteins: either electron transfer flavoprotein (ETF) ...
Petrie James R JR CSIRO Food Futures National Research Flagship, Canberra, Australian Capital Territory, - - 2014
Omega-3 long-chain (≥C20) polyunsaturated fatty acids (ω3 LC-PUFA) such as eicosapentaenoic acid (EPA) and docosapentaenoic acid (DHA) are critical for human health and development. Numerous studies have indicated that deficiencies in these fatty acids can increase the risk or severity of cardiovascular, inflammatory and other diseases or disorders. EPA and ...
Morrison Michael J MJ Departments of Chemistry and Biology, Massachusetts Institute of Technology , 77 Massachusetts Avenue, Cambridge, Massachusetts 02139, United - - 2014
Prokaryote-specific sugars, including N,N'-diacetylbacillosamine (diNAcBac) and pseudaminic acid, have experienced a renaissance in the past decade because of their discovery in glycans related to microbial pathogenicity. DiNAcBac is found at the reducing end of oligosaccharides of N- and O-linked bacterial protein glycosylation pathways of Gram-negative pathogens, including Campylobacter jejuni and ...
Goufo Piebiep P CITAB-Centre for the Research and Technology of Agro-Environment and Biological Sciences, Universidade de Trás-os-Montes e Alto Douro 5001-801, Vila Real, - - 2014
Epidemiological studies suggested that the low incidence of certain chronic diseases in rice-consuming regions of the world might be associated with the antioxidant compound contents of rice. The molecules with antioxidant activity contained in rice include phenolic acids, flavonoids, anthocyanins, proanthocyanidins, tocopherols, tocotrienols, γ-oryzanol, and phytic acid. This review provides ...
Grininger Martin M Institute of Organic Chemistry and Chemical Biology, Buchmann Institute for Molecular Life Sciences, Cluster of Excellence for Macromolecular Complexes, Goethe University Frankfurt, Max-von-Laue-Str. 15, 60438 Frankfurt am Main, Germany. Electronic address: - - 2014
Recently, atomic models of the mammalian, fungal and the bacterial fatty acid synthases type I (FAS I) were reported. Now, a wealth of functional data, collected during the last decades, can be embedded into structural frames. But there is more, which remains to be done! Our current considerations are implicitly ...
Xu Zhifeng - - 2014
Boronic acid affinity gels are important for effective separation of biological active cis-diols, and are finding applications both in biotech industry and in biomedical research areas. To increase the efficacy of boronate affinity separation, it is interesting to introduce repeating boronic acid units in flexible polymer chains attached on solid ...
Tilborg Anaëlle A Unité de Chimie Physique Théorique et Structurale, Dept. Chemistry, University of Namur, 61, Rue de Bruxelles, B-5000 Namur, Belgium. Electronic address: - - 2014
Salification of new drug substances in order to improve physico-chemical or solid-state properties (e.g. dissolution rate or solubility, appropriate workup process, storage for further industrial and marketing development) is a well-accepted procedure. Amino acids, like aspartic acid, lysine or arginine take a great part in this process and are implicated ...
Bohlke Nina N Chemistry, TU Berlin, Mueller-Breslau-Straße 10, Berlin, - - 2014
One of the major challenges in contemporary synthetic biology is to find a route to engineer synthetic organisms with altered chemical constitution. In terms of core reaction types, nature uses an astonishingly limited repertoire of chemistries when compared with the exceptionally rich and diverse methods of organic chemistry. In this ...
Xu Lubin L College of Chemistry and Pharmaceutical Sciences, Qingdao Agricultural University , Qingdao 266109, - - 2014
The catalyst-free sp(3) C-H functionalization of 2-alkylazaarenes has been achieved in the reaction with (thio)coumarin-3-carboxylic acids. Followed by a tandem decarboxylation, this method provides facile synthesis of biologically important azaarene-substituted 3,4-dihydro(thio)coumarins in a single step in high yields.
Unsworth William Paul - - 2014
Imines and carboxylic acids have been directly coupled using propylphosphonic acid anhydride and NEt(i-Pr)2 to give N acyliminium ions which were intramolecularly trapped with oxygen, nitrogen, sulfur, and carbon nucleophiles to provide a wide range of structurally diverse heterocycles.
Kennedy Allyson E AE Department of Biology, Virginia Commonwealth University, 1000 West Cary Street, Richmond, - - 2014
Xenopus has become a useful tool to study the molecular mechanisms underlying orofacial development. However, few quantitative analyses exist to describe the anatomy of this region. In this study we combine traditional facial measurements with geometric morphometrics to describe anatomical changes in the orofacial region during normal and abnormal development. ...
Ho Shih-Hsin SH Department of Chemical Engineering, National Cheng Kung University, Tainan 701, Taiwan; Organization of Advanced Science and Technology, Kobe University, Kobe, - - 2014
The optimal conditions for cultivating the thermotolerant lipid-rich microalga Desmodesmus sp. F2 to achieve maximal lipid productivity were determined in this study. The conditions were light intensity, 700μmol/m(2)s; temperature, 35°C; cultivation nitrogen source, nitrate; initial nitrogen level, 6.6mM nitrogen. Carbon dioxide (2.5%, 0.2 vvm) was pumped into the cultures continuously. ...
Manley David W - - 2014
Photochemical reactions employing TiO2 and carboxylic acids, under dry anaerobic conditions, led to several types of C-C bond forming processes with electron deficient alkenes. The efficiency of alkylation varied appreciably with substituents in the carboxylic acids. The reactions of aryloxyacetic acids with maleimides resulted in a cascade process in which ...
Su Jing J College of Food Science and Engineering, Northwest A&F University, Yangling, Xianyang, Shannxi, 712100, - - 2014
In an era of economic globalization, the competition among wine businesses is likely to get tougher. Biotechnological innovation permeates the entire world and intensifies the severity of the competition of the wine industry. Moreover, modern consumers preferred individualized, tailored, and healthy and top quality wine products. Consequently, these two facts ...
Wang Huai-Chun HC Department of Mathematics and Statistics, Dalhousie University, Halifax, Nova Scotia, B3H 4R2, - - 2014
Standard protein phylogenetic models use fixed rate matrices of amino acid interchange derived from analyses of large databases. Differences between the stationary amino acid frequencies of these rate matrices from those of a dataset of interest are typically adjusted for by matrix multiplication that converts the empirical rate matrix to ...
Kong Kien Voon KV Singapore Bioimaging Consortium, Agency for Science, Technology, and Research, - - 2014
In this work, we propose a novel glucose binding mechanism on a highly sensitive SERS substrate, in order to overcome challenges in specific glucose detection in bio-fluids. We make use of phenylboronic acid as a receptor for saccharide capture onto the substrate and the ability of the captured glucose molecule ...
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