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Wang Cuiping C Key Laboratory for Functional Material, Educational Department of Liaoning Province, University of Science and Technology Liaoning, Anshan, 114051, P. R. China. - - 2014
An efficient Cu-catalyzed decarboxylative C3-acylation of free (N-H) indoles using α-oxocarboxylic acids as acylating agents has been developed. This method was compatible with a variety of functional groups and provided an attractive alternative access to 3-acylindoles in moderate to high yields.
Dara Saidulu S Academy of Scientific and Innovative Research, CSIR-Indian Institute of Integrative Medicine, Jammu 180 001, India; Medicinal Chemistry Division, CSIR-Indian Institute of Integrative Medicine, Jammu 180 001, - - 2014
Here we report a high-yielding method for the regioselective reductive ring opening of 4,6-O-benzylidene acetals of hexapyranosides using inexpensive and robust HClO4-SiO2 as the acidic catalyst and triethylsilane as the hydride donor. Under the optimized condition, gluco- and mannopyranosides give the respective 6-O-benzyl derivative in good to excellent yields while ...
Santala Suvi S Department of Chemistry and Bioengineering, Tampere University of Technology , Tampere 33101, - - 2014
Wax esters are industrially relevant high-value molecules. For sustainable production of wax esters, bacterial cell factories are suggested to replace the chemical processes exploiting expensive starting materials. However, it is well recognized that new sophisticated solutions employing synthetic biology toolbox are required to improve and tune the cellular production platform ...
Wilent Jennifer - - 2014
The desymmetrization of prochiral diesters with a chiral phosphoric acid catalyst to produce highly enantioenriched lactones in excellent yield is reported. The process is easily scaled and accommodates a variety of substitution patterns, many of which result in the generation of an enantioenriched all-carbon quaternary center. Manipulation of lactone product ...
Shartau R B RB Department of Zoology, University of British Columbia, 6270 University Blvd., Vancouver, BC, V6T 1Z4 - - 2014
The evolution of air breathing during the Devonian provided early fishes with bimodal respiration with a stable O2 supply from air. This was, however, probably associated with challenges and trade-offs in terms of acid-base balance and ionoregulation due to reduced gill:water interaction and changes in gill morphology associated with air ...
Sardella Roccaldo R Dipartimento di Scienze Farmaceutiche, Università degli Studi di Perugia, Via Fabretti 48, 06123, Perugia, - - 2014
To the best of our knowledge enantioselective chromatographic protocols on β-amino acids with polysaccharide-based chiral stationary phases (CSPs) have not yet appeared in the literature. Therefore, the primary objective of this work was the development of chromatographic methods based on the use of an amylose derivative CSP (Lux Amylose-2), enabling ...
Gratzl Günther G Johannes Kepler University Linz, Institute for Chemical Technology of Organic Materials, Altenberger Str. 69, 4040 Linz, Austria. Electronic address: - - 2014
The increasing number of antibiotic-resistant bacterial strains has developed into a major health problem. In particular, biofilms are the main reason for hospital-acquired infections and diseases. Once formed, biofilms are difficult to remove as they have specific defense mechanisms against antimicrobial agents. Antimicrobial surfaces must therefore kill or repel bacteria ...
Matthaus B B a Max Rubner-Institut (MRI), Bundesforschungsinstitut für Ernährung und Lebensmittel, Institut für Sicherheit und Qualität bei Getreide , Schützenberg 12, D-32756 Detmold , - - 2014
The oleic acid content of seed oils varied between 21.4% (ATAEM7) and 26.6% (Türksoy). The proportion of linoleic acid of soybean oil ranged from 49.0% (Türksoy) to 53.5% (ATAEM7), while the palmitic acid of oils varied between 9.2% (Adasoy) and 11.2% (Noya). The major tocopherols were ¥-tocopherol, α-tocopherol and δ-tocopherol ...
Lee Heeyoung H Department of Biomedical Science, Daegu University, Gyeongsan 712-714, South Korea; Center for Bio-Nanomaterials, Daegu University, Gyeongsan 712-714, South - - 2014
In this study, we report the intrinsic catalytic activity of graphene oxide (GO) for the non-specific cleavage of proteins. We used bovine serum albumin (BSA) and a recombinant esterase (rEstKp) from the cold-adapted bacterium Pseudomonas mandelii as test proteins. Cleavage of BSA and rEstKp was non-specific regarding amino acid sequence, ...
Mukai Nobuhiko N National Research Institute of Brewing, 3-7-1 Kagamiyama, Higashihiroshima, Hiroshima 739-0046, Japan. Electronic address: - - 2014
Among industrial yeasts used for alcoholic beverage production, most wine and weizen beer yeasts decarboxylate ferulic acid to 4-vinylguaiacol, which has a smoke-like flavor, whereas sake, shochu, top-fermenting, and bottom-fermenting yeast strains lack this ability. However, the factors underlying this difference among industrial yeasts are not clear. We previously confirmed ...
Burchell Richard K RK Department of Companion Animal Clinical Studies, Faculty of Veterinary Science, University of Pretoria, Onderstepoort 0110, South Africa. Electronic address: - - 2014
The acid-base disturbances in canine parvoviral (CPV) enteritis are not well described. In addition, the mechanisms causing these perturbations have not been fully elucidated. The purpose of the present study was to assess acid-base changes in puppies suffering from CPV enteritis, using a modified strong ion model (SIM). The hypothesis ...
Te Vruchte Danielle - - 2014
Lysosomal storage disorders (LSDs) occur at a frequency of 1 in every 5,000 live births and are a common cause of pediatric neurodegenerative disease. The relatively small number of patients with LSDs and lack of validated biomarkers are substantial challenges for clinical trial design. Here, we evaluated the use of ...
Roy Iain D ID EaStCHEM, School of Chemistry, University of Edinburgh, Joseph Black Building, The King's Buildings, West Mains Road, Edinburgh, EH9 3JJ, - - 2014
A 2,4,6-trialkylanilide-containing chiral diene has been identified as a superior ligand for the enantioselective rhodium-catalyzed arylation of alkenylazaarenes with arylboronic acids.
Hampton Carissa S CS Department of Chemistry, University of Missouri-Columbia , 601 South College Avenue, Columbia, Missouri 65211, United - - 2014
In the course of a study of the alkoxyallylation of allenic sulfones through the use of π-allylpalladium chemistry, we discovered an isomerization of allenic sulfones to arylsulfonyl 1,3-dienes. Under conditions of palladium catalysis in the presence of acids such as acetic acid, allenic sulfones are converted to 1-arylsulfonyl 1,3-dienes. On ...
Liu Xin X Institute of Food Quality and Safety, Jiangsu Academy of Agricultural Sciences, - - 2014
In this study we characterized FgIlv5, a homologue of the Saccharomyces cerevisiae keto-acid reductoisomerase (KARI) from the important wheat head scab fungus Fusarium graminearum. KARI is a key enzyme in the branched-chain amino acids (BCAAs, including leucine, isoleucine and valine) biosynthetic pathway which exists in a variety of organisms from ...
Chen Yun Y Department of Chemical and Biological Engineering, Chalmers University of Technology, SE-41296 Göteborg, - - 2014
3-Hydroxypropionic acid (3-HP) is an attractive platform chemical, which can be used to produce a variety of commodity chemicals, such as acrylic acid and acrylamide. For enabling a sustainable alternative to petrochemicals as the feedstock for these commercially important chemicals, fermentative production of 3-HP is widely investigated and is centered ...
Hamner Heather C HC National Center on Birth Defects and Developmental Disabilities, Centers for Disease Control and Prevention, Atlanta, - - 2014
Corn masa flour, used to make products such as corn tortillas, is a staple food for Hispanic populations residing in the United States, particularly among Mexican Americans and Central Americans. Research has indicated that Hispanic women in the United States continue to be at a higher risk of having a ...
Bell Griffith A - - 2014
Evidence from experimental studies suggests that the long-chain ω-3 fatty acids eicosapentaenoic acid and docosahexaenoic acid have beneficial effects that may lead to reduced mortality from chronic diseases, but epidemiologic evidence is mixed. Our objective was to evaluate whether intake of long-chain ω-3 fatty acids from diet and supplements is ...
Huang Kun - - 2014
A novel bio-based epoxy monomer with conjugated double bonds, glycidyl ester of eleostearic acid (GEEA) was synthesized from tung oil fatty acids and characterized by 1H-NMR and 13C-NMR. Differential scanning calorimeter analysis (DSC) and FT-IR were utilized to investigate the curing process of GEEA with dienophiles and anhydrides. DSC indicated ...
Fernandez Melissa L ML Tissue Repair and Regeneration Program, Institute of Health and Biomedical Innovation, Queensland University of Technology, 60 Musk Avenue, Kelvin Grove, 4059, QLD, Australia, - - 2014
Chronic wounds are an important health problem because they are difficult to heal and treatment is often complicated, lengthy and expensive. For a majority of sufferers the most common outcomes are long-term immobility, infection and prolonged hospitalisation. There is therefore an urgent need for effective therapeutics that will enhance ulcer ...
Goyal Parag P , 402 East 67th Street, New York, NY, 10065, - - 2014
Among the range of lipid modifying medications currently available, statins clearly stand as the primary agent capable of reducing cardiovascular risk. While non-statin lipid-lowering drugs improve lipid parameters, their impact on clinical outcomes is less clear, thus necessitating an even closer look at ancillary effects. Recent studies have reported the ...
Bailey Steven H SH Dallas, Texas From the Department of Plastic Surgery, University of Texas Southwestern Medical - - 2014
Soft-tissue augmentation has become an increasingly popular option for facial rejuvenation. Hyaluronic acid fillers are part of the most rapidly expanding segment of this market, largely because of their safe drug profile and temporary nature. Despite their good safety profile, they can and do have complications ranging from superficial placement, ...
Castellani Christoph C Department of Pediatric and Adolescent Surgery, Medical University Graz, Auenbruggerplatz 34, 8036, Graz, Austria, - - 2014
To evaluate the influence of proton pump inhibitors (PPI) in predominantly milk-fed infants with symptoms of GERD by 24-h pH-multichannel intraluminal impedance (24-h pH-MII). Ten infants (8 males and 2 females) with a mean gestational age of 39 weeks (28-40) were included. 24-h pH-MII was performed before prescription and during intake of PPI. Total ...
Kalburge Sai Siddarth SS Department of Biological Sciences, University of Delaware, Newark, Delaware 19716, - - 2014
Adaptation to changing environmental conditions is an important strategy for survival of foodborne bacterial pathogens. Vibrio parahaemolyticus is a gram-negative seafoodborne enteric pathogen found in the marine environment both free living and associated with oysters. This pathogen is a moderate halophile, with optimal growth at 3 % NaCl. Among the ...
Tang Weizhuo W School of Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, People's Republic of China; Key Laboratory of Structure-Based Drug Design&Discovery Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, People's Republic of - - 2014
Zanthoxylum bungeanum Maxim seed (ZBMS) has been used in Traditional Chinese Medicine (TCM) as an ingredient of polyherbal formulations for the treatment of inflammation and asthma. The aim of this study was to analyze the major composition and to evaluate the anti-asthma activity of ZBMS. Some murine models including acetylcholine/histamine-induced ...
Salinas Dino G DG Centro de Investigación Biomédica, Facultad de Medicina, Universidad Diego Portales, Avda. Ejército 141, Santiago, Chile. Electronic address: - - 2014
Here we study the distribution of randomly generated partitions of the set of amino acid encoding codons. Some results are an application from a previous work, about the Stirling numbers of the second kind and triplet codes, both to the cases of triplet codes having four stop codons, as in ...
Lorenc Z Paul - - 2014
Reversal of the visible signs of facial aging with the use of injectable products as an alternative to surgery has become more popular, with nearly 5 million procedures performed in the United States in 2012. Volume augmentation products, such as hyaluronic acid (HA), calcium hydroxylapatite (CaHA), and poly-L-lactic acid (PLLA), ...
Xu Yong-Jiang YJ Key Laboratory of Insect Development & Evolutionary Biology, Institute of Plant Physiology & Ecology, Shanghai Institute for Biological Science, Chinese Academy of Sciences, NO 300 Fenglin Road, Shanghai 200023, People's Republic of China. - - 2014
Background: Fatty acids play important roles in the pathogenesis of many diseases. In order to investigate a wide spectrum of fatty acids in biological matrix, we developed an approach for quantitative analysis of fatty acids based on a heart-cutting 2D gas chromatographic-flame ionization detector system. Results: This system uses a ...
Taipale Sami J - - 2014
There is considerable interest in the pathways by which carbon and growth-limiting elemental and biochemical nutrients are supplied to upper trophic levels. Fatty acids and sterols are among the most important molecules transferred across the plant-animal interface of food webs. In lake ecosystems, in addition to phytoplankton, bacteria and terrestrial ...
Chakravarty Rubel - - 2014
This paper describes a systematic comparative evaluation of five commonly used bifunctional chelators, namely,p-isothiocyanato benzyl derivatives of diethylenetriaminepentacetic acid (DTPA-NCS), trans-cyclohexyl diethylenetriaminepentaceticacid (CHX-A″-DTPA-NCS), 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid (DOTA-NCS), 1,4,7-triazacyclononane-1,4,7-triacetic acid (NOTA-NCS), and 3,6,9,15-tetraazabicyclo [9.3.1]pentadeca-1(15),11,13-triene-3,6,9-triacetic acid (PCTA-NCS), on the basis of their ability to complex 90Y at room temperature, in vitro and in ...
Kimsey Isaac I Department of Biochemistry, Duke University Medical Center, Durham, NC 27710, United - - 2014
There are a growing number of studies reporting the observation of purine-pyrimidine base-pairs that are seldom observed in unmodified nucleic acids because they entail the loss of energetically favorable interactions or require energetically costly base ionization or tautomerization. These high energy purine-pyrimidine base-pairs include G•C(+) and A•T Hoogsteen base-pairs, which ...
Reddy Banda Venkat - - 2014
During the complete oxidation of fatty acids, the electrons removed from fatty acids in different forms (FADH2 and NADH2) pass through the respiratory chain, driving the ATP synthesis. Generally, the ATP yield due to the complete oxidation of fatty acids is calculated by sum total the ATPs obtained due to ...
Sassa Takayuki T Laboratory of Biochemistry, Faculty of Pharmaceutical Sciences, Hokkaido University, Kita-ku, Sapporo 060-0812, - - 2014
Fatty acids (FAs) are highly diverse in terms of carbon (C) chain-length and number of double bonds. FAs with C>20 are called very long-chain fatty acids (VLCFAs). VLCFAs are found not only as constituents of cellular lipids such as sphingolipids and glycerophospholipids but also as precursors of lipid mediators. Our ...
Nakano Takuo - - 2014
Sialic acid is a carbohydrate moiety of κ-casein glycomacropeptide (GMP), which is a 64 amino acid residue C-terminal sialylated phosphorylated glycopeptide released from κ-casein by the action of chymosin during cheese making. GMP lacks aromatic amino acids including phenylalanine, tyrosine, and tryptophan. Because of its unique amino acid composition and ...
Tegeder Mechthild M School of Biological Sciences, Washington State University, Pullman, WA 99164-4236, - - 2014
In most plant species, amino acids are the predominant chemical forms in which nitrogen is transported. However, in nodulated tropical or subtropical legumes, ureides are the main nitrogen transport compounds. This review describes the partitioning of amino acids and ureides within the plant, and follows their movement from the location ...
Jung N N Karlsruhe Institute of Technology, Campus North, Hermann-von-Helmholtz-Platz 1, 76344 Eggenstein-Leopoldshafen, - - 2014
A solid supported, odorless reagent for the dithioacetalization of aldehydes and ketones has been developed. The new reagent provides the dimercaptoalkane equivalent in combination with stoichiometric amounts of immobilized acid and enables the formation of dithianes and dithiolanes from aldehydes without any additives in good to very good yields with ...
Jambunathan Pooja P Department of Chemical Engineering and Materials Science, University of Minnesota, Twin Cities, MN 55455, - - 2014
Since traditional chemical processes are non-renewable and environmentally unfriendly, biosynthesis is emerging as an attractive alternative for the production of advanced biofuels, chemicals, pharmaceuticals and polymers. Cost-competitive biomanufacturing requires the design of metabolic pathways that can achieve high production yields and rates. Recent advances in natural amino acid production have ...
Kaulmann Anouk A Centre de Recherche Public - Gabriel Lippmann, Environment and Agro-biotechnologies Department, L-4422 Belvaux, - - 2014
The consumption of phytochemicals such as carotenoids and polyphenols within whole fruits and vegetables has been associated with decreased incidence of various inflammation and oxidative stress related chronic diseases, which may be due to direct antioxidant effects, or indirect mechanisms such as affecting signal transduction/gene expression. Within the present study, ...
Rit Raja K RK School of Chemistry, University of Hyderabad , Hyderabad-500046, - - 2014
Pd(II)-catalyzed ortho-C-H acetoxylation of arylacetic acid derivatives is demonstrated with the aid of a novel S-methyl-S-2-pyridylsulfoximine (MPyS) directing group (DG). The α-mono- and α-unsubstituted arylacetic acid derivatives were readily employed in the ortho-C-H acetoxylations. The oxidation products are hydrolyzed, and the MPyS-DG is easily recovered, providing ready access to o-hydroxyarylacetic ...
Tee Ting Wei TW Department of Chemical and Biological Engineering, Iowa State University, Ames, - - 2014
Increasing demand for petroleum has stimulated industry to develop sustainable production of chemicals and biofuels using microbial cell factories. Fatty acids of chain lengths from C6 to C16 are propitious intermediates for the catalytic synthesis of industrial chemicals and diesel-like biofuels. The abundance of genetic information available for Escherichia coli ...
Eddleston Mark D MD Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW, United - - 2014
The dissociation at high humidity of cocrystals formed between caffeine and theophylline with a series of dicarboxylic acids is investigated and found to be driven by the partial dissolution of the acid, rather than by the formation of caffeine/theophylline hydrate. It is shown that partial dissociation occurs under all humidity ...
Thyparambil Aby A AA Department of Bioengineering, 501 Rhodes Engineering Research Center, Clemson University, Clemson, SC - - 2014
The labeling of amino acid residues followed by peptide mapping via mass spectrometry (AAL/MS) is a promising technique to provide detailed information on the adsorption-induced changes in its solvent accessibility. However, the potential of this method for the study of adsorbed protein structure is largely undeveloped at this time. The ...
Miyoshi Yurika Y Graduate School of Pharmaceutical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, - - 2014
Enantioselective amino acid metabolome analysis of the Japanese traditional black vinegars (amber rice vinegar, Kurozu) was performed using two-dimensional high-performance liquid chromatography combining a microbore-monolithic ODS column and narrowbore-enantioselective columns. d-Amino acids, the enantiomers of widely observed l-amino acids, are currently paid attention as novel physiologically active substances, and the ...
Mascal Mark M Department of Chemistry, University of California Davis, 1 Shields Avenue, Davis, CA 95616 (USA). - - 2014
Dehydration of biomass-derived levulinic acid under solid acid catalysis and treatment of the resulting angelica lactone with catalytic K2 CO3 produces the angelica lactone dimer in excellent yield. This dimer serves as a novel feedstock for hydrodeoxygenation, which proceeds under relatively mild conditions with a combination of oxophilic metal and ...
Kim Moon-Il - - 2014
A cell-based assay system for simultaneous quantification of the three amino acids, phenylalanine (Phe), methionine (Met), and leucine (Leu) in a single biological sample, was developed and applied in the multiplex diagnosis of three key metabolic diseases of newborn babies. The assay utilizes three E. coli auxotrophs, which grow only ...
Shanmugam Muthu K MK Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, - - 2014
Oleanolic acid (OA, 3β-hydroxyolean-12-en-28-oic acid) is a ubiquitous pentacyclic multifunctional triterpenoid, widely found in several dietary and medicinal plants. Natural and synthetic OA derivatives can modulate multiple signaling pathways including nuclear factor-κB, AKT, signal transducer and activator of transcription 3, mammalian target of rapamycin, caspases, intercellular adhesion molecule 1, vascular ...
Teng Kim-Tiu - - 2014
Obesity plays a pivotal role in the development of low-grade inflammation. Dietary fatty acids are important modulators of inflammatory responses. Saturated fatty acids (SFA) and n-6 polyunsaturated fatty acids (PUFA) have been reported to exert pro-inflammatory effects. n-3 PUFA in particular, possess anti-inflammatory properties. Numerous clinical studies have been conducted ...
Wolters Lando P LP Department of Theoretical Chemistry, Amsterdam Center for Multiscale Modeling, VU University Amsterdam De Boelelaan 1083, 1081 HV Amsterdam (The - - 2014
Our purpose is to understand the mechanism through which pH affects the competition between base-induced elimination and substitution. To this end, we have quantum chemically investigated the competition between elimination and substitution pathways in H2O+C2H5OH2 (+) and OH(-)+C2H5OH, that is, two related model systems that represent, in a generic manner, ...
Roche Stéphane P SP Department of Chemistry and Biochemistry, Florida Atlantic University, 777 Glades Road, Boca Raton, FL 33431, USA. - - 2014
A novel acetyl chloride-mediated cascade transformation involving three components (benzyl carbamate, ethyl glyoxylate and arene nucleophiles) is reported. Aryl orthogonally protected α-amino acids are obtained in a one pot cascade, using a mild AcOH-AcCl system, via a critical autocatalytic dehydration-activation step ensuring an original and efficient Friedel-Crafts orchestration.
Peluso Ilaria I Department of Physiology and Pharmacology "V. Erspamer", "Sapienza" University of Rome , Rome , - - 2014
Abstract The metabolic syndrome can be prevented by the Mediterranean diet, characterized by fiber, omega-3 polyunsaturated fatty acids and polyphenols. However, the composition of the Mediterranean diet, which can be viewed as a natural multiple supplement, is poorly controlled, and its beneficial effects poorly predictable. The metabolic syndrome is associated ...
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