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Harohally Nanishankar V NV Food Safety and Analytical Quality Control Laboratory, CSIR-CFTRI, KRS Road, Mysore 570020, Karnataka, India. Electronic address: - - 2014
An efficient and practical protocol for the synthesis of Amadori ketoses N-(1-deoxy-d-fructose-1-yl) amino acid (amino acid=l-valine (1), l-leucine (2), l-isoleucine (3), l-tryptophan (4), l-phenylalanine (5), l-arginine (6) has been accomplished by employing ZnCl2 as a catalyst. The developed method circumvents protection and deprotection steps as well as tedious ion-exchange and ...
Sasaki M K MK NAPTISA/Center for Nuclear Energy in Agriculture, University of Sao Paulo, Piracicaba, - - 2014
An automated multi-pumping flow system is proposed for the chemiluminometric determination of ascorbic acid in pharmaceutical formulations, relying on the ability of semiconductor nanocrystals to generate short-lived reactive species upon photo-irradiation. A photo-unit based on visible-light-emitting diodes is used to photo-excite cadmium telluride (CdTe) quantum dots capped with glutathione, leading ...
Shao Zhuzhou Z College of Chemistry and Pharmaceutical Sciences, Qingdao Agricultural University, Qingdao, 266109, China. chemjxiao@gmail.com - - 2014
The tandem Michael addition/decarboxylation of (thio)coumarin-3-carboxylic acids with indoles has been developed and the biologically important indole-3-substituted dihydrocoumarins were obtained in good to excellent yields under catalyst-free conditions.
Hennum Martin - - 2014
The asymmetric nucleophilic 1,2-addition of (S)-N-benzylidene-2-methylpropane-2-sulfinamide with methylmagnesium bromide and methyllithium has been investigated using DFT(B3LYP) computations. The calculated ratio of the two diastereomers agrees with experimental observations and the factors that determine the diastereomeric ratio are discussed. The preference for the E isomer and the rapid equilibrium between the ...
Martínez-Moreno Rubén R Instituto de Ciencias de la Vid y del Vino (CSIC, Universidad de La Rioja, Gobierno de la Rioja), C/Madre de Dios, 51, 26006 Logroño, La Rioja, - - 2014
Nitrogen limitation is the most common cause for stuck or sluggish fermentation in winemaking, and it is usually dealt with by supplementing grape juice with either ammonium salts or organic nutrients. These practices have a direct impact on both fermentation kinetics and the sensorial features of the final product. The ...
Bonafé Luisa L aCenter for Molecular Diseases, Lausanne University Hospital bAdult Intensive Care & Burns, Lausanne University Hospital, Lausanne, Switzerland cDivision of Endocrinology, Diabetes, and Bone Disease, Icahn School of Medicine at Mount Sinai, New York, New York, - - 2014
New insight in mitochondrial physiology has highlighted the importance of mitochondrial dysfunction in the metabolic and neuroendocrine changes observed in patients presenting with chronic critical illness. This review highlights specifically the importance of carnitine status in this particular patient population and its impact on beta-oxidation and mitochondrial function. The main ...
Thumser Alfred E AE aDepartment of Biochemistry and Physiology bDepartment of Nutritional Sciences, Faculty of Health and Medical Sciences, University of Surrey, Guildford, - - 2014
The purpose of this study is to review recent evidence for the role of the cytosolic fatty acid binding proteins (FABPs) as central regulators of whole-body metabolic control. Dysregulated FABPs have been associated with a number of diseases, including obesity and nonalcoholic fatty liver disease (FABP1, FABP2, FABP4), cardiovascular risk ...
Di Girolamo Filippo Giorgio FG aClinica Medica AOUTS, Department of Medical Sciences, University of Trieste bOrthopedic Unit AOUTS cGeriatric Unit AOUTS, Trieste, - - 2014
The increased age observed in most countries, with the associated higher rates of chronic illnesses and cancer, and a diffuse sedentary lifestyle, will increase the number of patients with clinically relevant anabolic resistance, sarcopenia and its complications. The need for solutions to this major health issue is, therefore, pressing. The ...
Keum Nana N Department of Nutrition and Epidemiology, Harvard School of Public Health, Boston, - - 2014
The U.S. has been reported as the only country experiencing a decline in incidence rates of colorectal cancer (CRC), despite increasing prevalence of CRC major risk factors, including the Western dietary pattern and obesity. This paper presents a hypothesis that improved folate status in the U.S. is the factor that ...
Bardaweel Sanaa K - - 2014
Homochirality is fundamental for life. L-Amino acids are exclusively used as substrates for the polymerization and formation of peptides and proteins in living systems. However, D- amino acids were recently detected in various living organisms, including mammals. Of these D-amino acids, D-serine has been most extensively studied. D-Serine was found ...
Kwong Raymond W M RW Department of Biology, University of Ottawa, 30 Marie Curie, Ottawa, ON, Canada, K1N - - 2014
Ionic regulation and acid-base balance are fundamental to the physiology of vertebrates including fish. Acidification of freshwater ecosystems is recognized as a global environmental problem, and the physiological responses to acid exposure in a few fish species are well characterized. However, the underlying mechanisms promoting ionic and acid-base balance for ...
Hussain Shahzad S Drugs Control and Traditional Medicines Division, National Institute of Health, Islamabad, - - 2014
Medicinal plants are believed to be a precious natural reservoir as they are assumed to have paranormal effects for the mankind. Moringa oleifera grows throughout most of the tropics and has numerous industrial and medicinal uses. This review acquaints with the consequence of fera (Moringaceae), a fast growing medicinal plant ...
Salim Vonny V Department of Biological Sciences, 500 Glenridge Avenue, Brock University, St. Catharines, Ontario L2S 3A1, Canada. Electronic address: - - 2014
Iridoids are key intermediates required for the biosynthesis of monoterpenoid indole alkaloids (MIAs), as well as quinoline alkaloids. Although most iridoid biosynthetic genes have been identified, one remaining three step oxidation required to form the carboxyl group of 7-deoxyloganetic acid has yet to be characterized. Here, it is reported that ...
Pinto Andrea A Dipartimento di Scienze Farmaceutiche DISFARM, Università degli Studi di Milano, Via Mangiagalli 25, 20133 Milano, Italy. Electronic address: - - 2014
A convenient synthesis of four new enantiomerically pure acidic amino acids is reported and their affinity at ionotropic glutamate receptors was determined. The new compounds are higher homologues of glutamic acid in which the molecular complexity has been increased by introducing an aromatic/heteroaromatic ring, that is a phenyl or a ...
Garrett Andrew R AR Department of Microbiology and Molecular Biology, Brigham Young University, 855 WIDB, Provo, UT 84602, - - 2014
Epidemiological studies show a positive correlation between oxidative stress and chronic disease development such as heart disease and cancer. While several antioxidant compounds with varying physical and chemical characteristics are able to reduce oxidative stress in biological systems, relatively few studies have been performed to examine the structural characteristics that ...
Ragavendra Thayappa Raju - - 2014
Use of acids and other caustic substances in destroying the human body to avoid personal identification is drawing great deal of attention in recent times. With rapid industrial growth, incidence of industrial disasters has increased. In an event of chemical industry disaster, human identification can become a challenge. Embedding bar ...
Gharby Said S University Mohammed V-Agdal, Rabat, Morocco (S.G., H.H., B.K., Z.C.), University of Reims Champagne Ardenne, Reims, France (D. G.), Universiapolis, Agadir, Morocco (I. C.-M.), and INRA-CRRA Agadir, Morocco - - 2014
The objective of this work is to determine the chemical stability of cosmetic argan oil (INCI: Argania spinosa kernel oil). The methodology involves the repeated measurement over a 1-year period of the quality metrics used in the cosmetic industry: acid and peroxide value and specific absorbance. During this year, storage ...
Kalinic Dubravka - - 2014
Aim. To explore the association between plasma fatty acids composition and the severity of clinical symptoms in Croatian war veterans with posttraumatic stress disorder (PTSD). Methods. This cross-sectional study included 62 men diagnosed with PTSD caused by combat activities during the War in Croatia 1991-1995. Clinician-Administered PTSD Scale (CAPS), Hamilton ...
Malan André A Institute for Cellular and Integrative Neurosciences, CNRS and University of Strasbourg, 5 Rue Blaise Pascal, 67084 Strasbourg Cedex, - - 2014
The conquest of land has endowed air-breathers with the capability to utilize ventilation not only to acquire oxygen but also to control blood and intracellular acid-base state. Hypercapnic acidosis (resulting from ventilatory control and/or behavioral choice), thus, has become a universal component of hypometabolic states in air-breathers, with inhibitory and/or ...
He Yanqing Y State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, 130 Meilong Road, Shanghai 200237, - - 2014
Impregnation of lignocellulose materials with dilute acid solution is a routine operation in conventional dilute acid pretreatment. The dry dilute acid pretreatment (DDAP) at high solids content up to 70% is naturally considered to require longer impregnation time. In this study, a co-currently feeding operation of corn stover and dilute ...
Wang Yechun Y Donald Danforth Plant Science Center, 975 North Warson Road, Saint Louis, MO, 63132, - - 2014
Malonyl-CoA is the essential building block of natural products such as fatty acids, polyketides, and flavonoids. Engineering the biosynthesis of fatty acids is important for biofuel production while that of polyketides provides precursors of medicines and nutritional supplements. However, microorganisms maintain a small amount of cellular malonyl-CoA, which could limit ...
Hibi Makoto M Industrial Microbiology, Graduate School of Agriculture, Kyoto University, Kitashirakawa-oiwakecho, Sakyo-ku, Kyoto, 606-8502, - - 2014
The asymmetric hydroxylation of inactive carbon atoms is still an important reaction in the industrial synthesis of valuable chiral compounds such as pharmaceuticals and fine chemicals. Applications of monooxygenation enzymes, like cytochrome P450 monooxygenases, flavin-containing monooxygenases, and Fe(II)/α-ketoglutarate-dependent dioxygenases (Fe/αKG-DOs), are strongly desired as hydroxylation biocatalysts because they have great ...
Longhi Catia C Department of Public Health and Infectious Diseases, Sapienza University, P.le A. Moro 5, 00185 Rome, Italy. Electronic address: - - 2014
It has been suggested that the rarity of human listeriosis due to Listeria ivanovii reflects not only host tropism factors but also the rare occurrence of this species in the environment, compared with Listeria monocytogenes. In the present study we evaluate the effects on the reference strain L. ivanovii ATCC 19119 ...
Finkbeiner Peter P Institut für Organische Chemie, Eberhard Karls Universität Tübingen , Auf der Morgenstelle 18, 72076 Tübingen, - - 2014
An efficient electrophilic alkynylation of azlactones (oxazol-5(4H)-ones) is developed using alkynyl(phenyl)iodonium salts as the electrophilic alkyne source. After remarkably short reaction times, the desired alkyne functionalized azlactones are obtained in 60-97% yield and can be transformed easily into a variety of quaternary α-amino acid derivatives.
Kotouńćová Hana H Department of Organic Chemistry, Institute of Chemical Technology, Prague, Technická 5, 16628 Prague 6, Czech Republic. - - 2014
Flavin-catalysed oxidative hydroxylation of substituted arylboronic acids by molecular oxygen with the assistance of hydrazine or ascorbic acid resulted in phenols in high yields. This mild organocatalytic protocol is compatible with a variety of functional groups and it is alternatively usable for transformation of alkylboronic acids to alcohols. Reaction takes ...
Schäfer Gabriel G Laboratorium für Organische Chemie, Department of Chemistry and Applied Biosciences, ETH Zürich , Vladimir Prelog Weg 1-5, 8093 Zürich, - - 2014
Sterically hindered N-acyl, gem-disubstituted amino acids are easily prepared via the addition of organometallic reagents to N-carboxyanhydrides (NCA). The process tolerates a wide variety of functional groups and allows the synthesis of amide products not readily accessible by traditional acylation chemistry. The existence of an isocyanate intermediate was established by ...
Zhou Pan-Pan - - 2014
Nicotinic acid is a well-known pharmaceutical in vitamin B group that has attracted great interest in the past decades due to its significant importance in the treatment of the human diseases like pellagra. Also, nicotinic acid derivatives have been devoted to much attention due to their different pharmaceutical effects in ...
Vilcocq Léa L Centro de Química da Madeira, Universidade da Madeira, Campus da Penteada, 9020-105 Funchal - - 2014
Mild fractionation/pretreatment processes are becoming the most preferred choices for biomass processing within the biorefinery framework. To further explore their advantages, new developments are needed, especially to increase the extent of the hydrolysis of poly- and oligosaccharides. A possible way forward is the use of solid acid catalysts that may ...
Subba Reddy Basireddy Venkata - - 2014
An unprecedented oxa- vs thia- selectivity has been observed in Prins cyclization of 6-mercaptohex-3-en-1-ol with aldehydes. In the presence of a stoichiometric amount of strong Lewis or Bronsted acids,the reaction provides the hexahydro-2H-thieno[3,2-c]pyran skeleton predominantly via oxonium-Prins cyclization. In contrast, a catalytic amount of weak Lewis or Bronsted acids provides ...
Ma Xiao X School of Chemistry, Northeast Normal University, Changchun, 130024 (P. R. China), Fax: - - 2014
Carbon nanotubes (CNTs) have been widely employed as electrode materials in diverse branches of electrochemistry, which are claimed to display dramatically improved electrochemical behaviour compared to the conventional carbon materials. But a series of recent publications have demonstrated that the electrocatalysis of CNTs might be due to the presence of ...
Gualandi Andrea A Dipartimento di Chimica "G. Ciamician", ALMA MATER STUDIORUM, Università di Bologna, Via Selmi 2, 44126, Bologna (Italy), Fax: - - 2014
In recent years there has been an accelerated rate of development in the field of organocatalysis, with asymmetric organocatalysis now reaching full maturity. The invention of new organocatalytic reactions and the exploration of new concepts now appear in tandem with the application of organocatalytic techniques in the synthesis of natural ...
Zhang Di D Department of Landscape Science and Engineering, School of Agriculture and Biology, Shanghai Jiao Tong University, Shanghai 200240, - - 2014
The transition from vegetative to reproductive growth represents a major phase change in angiosperms. Hormones play important roles in this process. In this study, gibberellic acid (GA), cytokinins (CKs), indoleacetic acid (IAA), and abscisic acid (ABA) were analyzed during the flowering in Agapanthus praecox ssp. orientalis. Eleven types of endogenous ...
Yang Senpei S CAU & ACC Joint-Laboratory of Space Food, College of Food Science and Nutritional Engineering, Beijing Key Laboratory of Functional Food from Plant Resources, China Agricultural University, Beijing 100083, - - 2014
Under physiological conditions, exogenous chelators such as polyphenols might interact with non-protein bound ferric complexes, such as Fe(III)-citrate. Additionally, Fe(III) and citrate are widely distributed in various fruits and vegetables which are also rich in phenolic acids. In this study, we focus on the interaction between phenolic acids (gallic acid, ...
Xu Yu Y School of Chemistry and Chemical Engineering, Shandong University, Jinan 250100, PR China; Taishan College, Shandong University, Jinan 250100, PR - - 2014
A novel turn-off fluorescent probe based on coumarin and imidazole moiety for extremely acidic conditions was designed and developed. The probe with pKa=2.1 is able to respond to very low pH value (below 3.5) with high sensitivity relying on fluorescence quenching at 460nm in fluorescence spectra or the ratios of ...
Sullivan Michael L ML US Dairy Forage Research Center, US Department of Agriculture, Agricultural Research Service, 1925 Linden Drive, Madison, WI, 53705, USA, - - 2014
Many plants accumulate hydroxycinnamoyl esters to protect against abiotic and biotic stresses. Caffeoyl esters in particular can be substrates for endogenous polyphenol oxidases (PPOs). Recently, we showed that perennial peanut (Arachis glabrata Benth.) leaves contain PPO and identified one PPO substrate, caftaric acid (trans-caffeoyl-tartaric acid). Additional compounds were believed to ...
Fenech Goël G Paris Descartes University, Faculty of Medicine, AP-HP, Diagnosis and Therapeutic Center, Hôtel-Dieu University Hospital, place du Parvis-Notre-Dame, Paris, - - 2014
Hyperuricaemia is commonly found in subjects with cardiovascular disease, but its role as risk factor is very controversial. Although several studies reported serum uric acid as a marker of an underlying pathophysiological process, other studies hypothesis a potential causal link between serum uric acid and cardiovascular diseases. Some studies suggest ...
Guschina Irina A IA School of Biosciences, Cardiff University, Cardiff CF10 3AX, - - 2014
Although there is much knowledge of the enzymology (and genes coding their proteins) of lipid biosynthesis in higher plants, relatively little attention has been paid to regulation. We have demonstrated the important role for cholinephosphate cytidylyltransferase in the biosynthesis of the major extra-plastidic membrane lipid, phosphatidylcholine. We followed this work ...
Berry Susan A SA University of Minnesota, Minneapolis, MN, USA. Electronic address: - - 2014
To evaluate glycerol phenylbutyrate (GPB) in the treatment of pediatric patients with urea cycle disorders (UCDs). UCD patients (n=26) ages 2months through 17years were treated with GPB and sodium phenylbutyrate (NaPBA) in two short-term, open-label crossover studies, which compared 24-hour ammonia exposure (AUC0-24) and glutamine levels during equivalent steady-state dosing ...
Pinto Isabel S S IS 1REQUIMTE, Departamento de Engenharia Química, Faculdade de Engenharia, Universidade do Porto, Rua Dr. Roberto Frias, 4200-465, Porto, - - 2014
Aminopolycarboxylates, like ethylenediaminetetraacetic acid (EDTA) and diethylenetriaminepentaacetic acid (DTPA), are chelating agents widely used in several industrial, agricultural, and domestic applications. However, the fact that they are not biodegradable leads to the presence of considerable amounts in aquatic systems, with serious environmental consequences. The replacement of these compounds by biodegradable ...
Lemercier Bérénice C BC Department of Chemistry, North Carolina State University , Raleigh, North Carolina 27695, United - - 2014
An improved and expanded preparation of thiohydroxamic acids is reported along with a one-pot conversion of these compounds to novel thiohydroximic acid derivatives. A variety of aryl, heteroaryl, and alkyl substituents are well tolerated to provide a rapid approach to alkene-functionalized thiohydroximic acids that serve as potentially useful building blocks ...
Sydney Eduardo Bittencourt EB Bioprocess Engineering and Biotechnology Department, Federal University of Parana, Centro Politécnico, Usina Piloto B, CEP 81531-990 Curitiba, Paraná, Brazil; Clermont Université, Université Blaise Pascal, Labex IMobS3, Institut Pascal, Polytech Clermont-Ferrand, 24 avenue des Landais, BP 20206, 63174 Aubière Cedex, - - 2014
This work evaluates the potential of vinasse (a waste obtained at the bottom of sugarcane ethanol distillation columns) as nutrient source for biohydrogen and volatile fatty acids production by means of anaerobic consortia. Two different media were proposed, using sugarcane juice or molasses as carbon source. The consortium LPBAH1 was ...
Cronan John E JE Departments of Microbiology and Biochemistry, University of Illinois, Urbana, Illinois - - 2014
The Firmicute bacteria readily incorporate exogenous fatty acids into their phospholipids. In some (but not all) family members incorporation of the fatty acids present in human serum precludes the use of fatty acid synthesis inhibitors to treat infections. However, the pathway(s) of exogenous fatty acid incorporation in these bacteria remained ...
Xu Xianghuai X Department of Respiratory Medicine, Tongji Hospital, Tongji University School of Medicine, Shanghai, - - 2014
Little is known about non-acid gastroesophageal reflux-induced chronic cough (GERC). The purpose of the study is to explore the clinical characteristics of non-acid GERC. Clinical symptoms, cough symptom score, capsaicin cough sensitivity, gastroesophageal reflux diagnostic questionnaire (GerdQ) score, findings of multichannel intraluminal impedance-pH monitoring (MII-pH) and response to pharmacological anti-reflux ...
Arean Carlos O CO Department of Chemistry, University of the Balearic Islands, 07122 Palma de Mallorca, Spain. - - 2014
Brønsted-acid zeolites are currently being used as catalysts in a wide range of technological processes, spanning from the petrochemical industry to biomass upgrade, methanol to olefin conversion and the production of fine chemicals. For most of the involved chemical processes, acid strength is a key factor determining catalytic performance, and ...
Wagner Anna M AM Department of Chemistry, University of Michigan , 930 North University Avenue, Ann Arbor, Michigan 48109, United - - 2014
The preparation of diaryl and alkyl aryl sulfides via acid-mediated coupling of thiols and thioethers with diaryliodonium salts is reported. The scope, limitations, and mechanism of the transformation are discussed.
Yu Haibo H School of Chemistry, University of Wollongong, Wollongong NSW 2552, Australia. - - 2014
Glycoside hydrolase families 33 and 34 catalyse the hydrolysis of terminal sialic acid residues from sialyl oligosaccharides and glycoconjugates with a net retention of the stereochemistry at the anomeric centre. It is generally believed that the conserved aspartic acid in the active site functions as a general acid to protonate ...
Peng Wei - - 2014
Triterpenoids were thought to be biologically ineffective for a very long time, but aggregating proof on their widely range pharmacological activities paired with dubious toxicity portrait has motivated regenerated attraction for human health and disease. In the current contribution, our central goal was to integrative dissect the biointeraction of two ...
Wulff-Pérez Miguel M Biocolloid and Fluid Physics Group, Department of Applied Physics, Faculty of Sciences, University of Granada, 18071 Granada, - - 2014
Oral drug delivery systems based on lipids are biodegraded in a process called lipolysis to release free fatty acids and monoglycerides. The rate of this lipolysis is usually measured by pH titration. Nevertheless, this technique has some limitations, such as not providing any information about the actual composition of the ...
Sherlock Huang Lin-Chiang LC Nuclear Science & Technology Development Center, National Tsing Hua University, Hsinchu 30013, Taiwan; Department of Chemistry, National Tsing Hua University, Hsinchu 30013, - - 2014
This work presents a novel approach for labeling hippuric acid with I-131 using microwaves. It utilizes copper(II) acetate as a catalyst of the labeling. The process involves the use of this catalytic copper(II) acetate at low dilutions that were nevertheless sufficient to produce labeled hippuric acid with high radiochemical purity ...
Kern Wolfram W Biologics Process Research and Development, Novartis Pharma, Postfach, 4002 Basel, - - 2014
Isomerization of aspartic acid residues is one of the major causes of chemical degradation during the shelf life of biological pharmaceuticals. Monoclonal antibody biopharmaceuticals are typically stored at mildly acidic pH conditions, which can lead to the isomerization reaction. The mechanism of this non-enzymatic chemical reaction has been studied in ...
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