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Chakraborty Surajit - - 2014
The scenario of tuberculosis has gone deadly due to its high prevalence and emergence of widespread drug resistance. It is now high time to develop novel antimycobacterial strategies and to understand novel mechanisms of existing antimycobacterial compounds so that we are equipped with newer tuberculosis controlling molecules in the days ...
Edward Heather L HL Departments of Medicine, and Pathology and Laboratory Medicine, Division of Hematology/Oncology, Boston University School of Medicine , Boston, Massachusetts , USA - - 2014
Abstract Hb Youngstown is a rare hemoglobin (Hb) variant caused by substitution of glutamic acid with alanine at amino acid residue 101 of the β-globin chain as a result of an A > C transversion on the β-globin gene nucleotide sequences [β101(G3)Glu → Ala; HBB: c.305A > C]. We now report three patients from two different ...
Valentinuzzi Fabio F Faculty of Science and Technology, Free University of Bolzano, Piazza Universitá 5, 39100, Bolzano, - - 2014
Among berries strawberry fruits are one of the richest natural sources of health beneficial components as micronutrients, antioxidants and phytochemicals. Strawberry quality varies greatly upon genotype, environmental factors, cultivation techniques and nutrient supply. The study aimed to assess the influence of phosphorus (P) and iron (Fe) deficiency on the bioactive ...
Kayadibi Huseyin H Huseyin Kayadibi, Department of Medical Biochemistry, Adana Military Hospital, Adana 01150, - - 2014
Red cell distribution width (RDW) may play an important role in predicting steatohepatitis and liver fibrosis. In the original study, it was aimed to determine whether RDW could be used for this purpose or not. There are studies indicating that higher RDW is correlated well with components of metabolic syndrome. ...
Li Guanghui G School of Minerals Processing & Bioengineering, Central South University, Changsha, Hunan 410083, China. Electronic address: - - 2014
The feasibility of an integrated technological route for comprehensive utilization of red mud was verified in this study. Valuable components in the mud, including Fe2O3, Al2O3 and SiO2 were stepwise extracted by magnetic separation and sulfuric acid leaching from reduced red mud, and meanwhile TiO2 was enriched in the leaching ...
Wei Wei W The Key Laboratory of Life-Organic Analysis and Key Laboratory of Pharmaceutical Intermediates and Analysis of Natural Medicine, School of Chemistry and Chemical Engineering, Qufu Normal University, Qufu 273165, Shandong, China. - - 2014
A novel iron-catalyzed direct difunctionalization of alkenes with sulfinic acids and dioxygen for the synthesis of β-ketosulfones has been developed under mild conditions. The present protocol, which utilizes an inexpensive iron salt as the catalyst, readily available benzenesulfinic acids as the sulfonylating reagents, and dioxygen as the oxidant and oxygen ...
Weng Huachun H From the Department of Genomic Medicine, National Cerebral and Cardiovascular Center, Suita, Osaka, Japan. weng@ncvc.go.jp - - 2014
Although proteinuria is known to be associated with the deterioration of chronic kidney disease, the molecular basis of this mechanism is not fully understood. We previously found that Pex11a deficiency was associated with a reduction of functional peroxisomes and impaired fatty acid metabolism in hepatocytes and resulted in steatosis. Proximal ...
Juurlink Bernhard Hj - - 2014
Today we are beginning to understand how phytochemicals can influence metabolism, cellular signaling and gene expression. The hydroxybenzoic acids are related to salicylic acid and salicin, the first compounds isolated that have a pharmacological activity. In this review we examine how a number of hydroxyphenolics have the potential to ameliorate ...
Turak Osman O Department of Cardiology, Türkiye Yüksek Ihtisas Education and Research Hospital, Ankara, - - 2014
Early morning blood pressure surge (MBPS) is a risk factor for cardiovascular events (CVEs), but the relationship with uric acid is not well understood. The authors aimed to determine the association between MBPS and increased uric acid and the effect of elevated MBPS and uric acid combination on CVEs. A ...
Yuzbashian Emad E Nutrition and Endocrine Research Center, Obesity Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, - - 2014
Although dietary components may play a role in the development of chronic kidney disease (CKD), data on this topic are scarce. The objective of this study was to investigate the association between macronutrient intakes and CKD in a large non-diabetic adult population-based study. This cross-sectional study recruited 5,316 participants aged ...
Charles Rebecca L RL King's College London, Cardiovascular Division, British Heart Foundation Centre of Excellence, The Rayne Institute, St. Thomas' Hospital, London SE1 7EH, United - - 2014
Soluble epoxide hydrolase (sEH) is inhibited by electrophilic lipids by their adduction to Cys521 proximal to its catalytic center. This inhibition prevents hydrolysis of the enzymes' epoxyeicosatrienoic acid (EET) substrates, so they accumulate inducing vasodilation to lower blood pressure (BP). We generated a Cys521Ser sEH redox-dead knockin (KI) mouse model ...
Mallamaci Francesca F aCNR-IBIM, Reggio Calabria bUnità Operativa di Nefrologia, Ipertensione e Trapianto Renale Ospedali Riuniti, Reggio Calabria, - - 2014
Hyperuricemia associates with hypertension, but it is uncertain whether this relationship is causal in nature. Glucose transporter 9 (GLUT9) gene is a major genetic determinant of plasma uric acid levels in humans. Since polymorphisms are randomly distributed at mating (Mendelian randomization), studies based on GLUT9 polymorphisms may provide unconfounded assessment ...
Colussi Gianluca G Hypertension Unit, Clinica Medica, Department of Experimental and Clinical Medical Science, University of - - 2014
Aim: The composition of dietary fat affects various modifiable cardiovascular risk factors and cardiovascular outcomes in the general population. We investigated the effects of the regular consumption of fish meals on the fatty acid composition of red blood cell (RBC) membranes and the relationship of this parameter with the carotid ...
Bhullar Khushwant S KS Department of Environmental Sciences, Faculty of Agriculture, Dalhousie University, Truro, NS, Canada B2N - - 2014
Hypertension is a crucial risk factor for cardiovascular diseases and contributes to one third of global mortality. In addition to conventional antihypertensive drugs such as captopril, naturally occurring phytochemicals and their analogs are used for reducing the risk and occurrence of hypertension. Herein, we demonstrate the possible use of caffeic ...
Boban Milojkovic M Department of Biochemistry - - 2014
Abstract Purine nucleotide liberation and their metabolic rate of interconversion may be important in the development of hypertension and its renal consequences. In the present study, blood triphosphate (ATP), adenosine diphosphate (ADP), and adenosine monophosphate (AMP) breakdown pathway was evaluated in relation to uric acid concentration and xanthine dehydrogenase/xanthine oxidase ...
Hemnes Anna R AR 1 Division of Pulmonary and Critical Care - - 2014
Shorter survival in heritable pulmonary arterial hypertension (HPAH), often due to BMPR2 mutation, has been described in association with impaired right ventricle (RV) compensation. HPAH animal models are insulin resistant, and cells with BMPR2 mutation have impaired fatty acid oxidation, but whether these findings affect the RV in HPAH is ...
Dhaun Neeraj N Clinical Pharmacology Unit, University of Edinburgh, The Queen׳s Medical Research Institute, Edinburgh, UK. Electronic address: - - 2014
Elevated serum uric acid is detected in pulmonary arterial hypertension (PAH) and is associated with poor patient outcomes. High serum uric acid is an independent risk factor for cardiovascular disease and renal impairment. We analyzed the effects of endothelin receptor antagonism on serum uric acid in PAH patients participating in ...
Miyazaki Satoshi S Division of Cardiology, Nojima Hospital , Kurayoshi , Japan - - 2014
Abstract Purpose: To examine effects of a long-acting calcium channel blocker (CCB) azelnidipine on uric acid metabolism in hypertensive patients. Methods: Azelnidipine was administered to 72 patients at a daily dose of 8 mg or 16 mg. In 22 cases out of the 72 patients, a different CCB was switched to azelnidipine. ...
Feig Daniel I DI Department of Pediatrics, Division of Nephrology, University of Alabama, Birmingham School of Medicine. Birmingham, Alabama, - - 2014
To discuss the evolving data regarding uric acid as a potential cause of hypertension and progressive renal dysfunction and its clinical and research implications. The potential mechanisms by which uric acid could cause vasoconstriction and a progressive ateriolopathy were established in animal models between 1999 and 2004. Since then, there ...
Yang Rui R School of Medicine, Southeast University, Nanjing, Jiangsu Province, People's Republic of - - 2014
This study aimed to generate targeted folic acid-conjugated, doxorubicin-loaded, magnetic iron oxide bovine serum albumin nanospheres (FA-DOX-BSA MNPs) that lower the side effects and improve the therapeutic effect of antitumor drugs when combined with hyperthermia and targeting therapy. A new nanodrug using magnetic nanospheres for heating and addition of the ...
Moya-Beltrán Ana A Fundación Ciencia & Vida, Santiago, - - 2014
"Ferrovum myxofaciens" is an iron-oxidizing betaproteobacterium with widespread distribution in acidic low-temperature environments, such as acid mine drainage streams. Here, we describe the genomic features of this novel acidophile and investigate the relevant metabolic pathways that enable its survival in these environments.
Chobot Vladimir V Division of Molecular Systems Biology, Department of Ecogenomics and Systems Biology, Faculty of Life Sciences, University of Vienna, Althanstrasse 14, A-1090 Vienna, Austria. - - 2014
Iron is an essential co-factor for many enzymes that catalyze electron transfer reactions. It is well known that so-called "poorly liganded" iron can increase ROS concentrations and trigger oxidative stress that is capable of initiating apoptosis. Conversely, controlled ROS production has been recognized as an integral part of cellular signaling. ...
Bačová B B Institute for Heart Research, Slovak Academy of Sciences, Bratislava, - - 2013
Polyunsaturated omega-3 fatty acids (omega-3 PUFA) are important components of cell membrane affecting its function and their deficiency is deleterious to health. We have previously shown that spontaneously hypertensive rats (SHR) are prone to life-threatening arrhythmias that are reduced by omega-3 PUFA intake. Purpose of this study was to explore ...
Song Kun - - 2013
Previous epidemiologic studies have demonstrated an association between uric acid and hypertension. Our objective was to conduct a prospective cohort study with a nested randomised controlled trial (RCT in cohort) that aims to identify the association of hyperuricemia with the development of hypertension and to examine the efficacy of dietary ...
Sanphui Palash - - 2013
Sildenafil is a drug used to treat erectile dysfunction and pulmonary arterial hypertension. Because of poor aqueous solubility of the drug, the citrate salt, with improved solubility and pharmacokinetics, has been marketed. However, the citrate salt requires an hour to reach its peak plasma concentration. Thus, to improve solubility and ...
Gonzalez-Muñoz Adrian - - 2013
Thirty-three Chilean corn accessions were screened for the first time regarding their phenolic profiles, total phenolic contents (TPC), antioxidant capacity (DPPH and ABTS) and the in vitro inhibition against key enzymes relevant for hyperglycemia (α-amylase and α-glucosidase) and hypertension (angiotensin I-converting enzyme, ACE-I) in both free and cell wall-bound fractions. ...
Chaudhary Kunal K Harry S. Truman Veterans' Hospital, Columbia, Mo., USA ; Division of Nephrology, Department of Medicine, University of Missouri, Columbia, Mo., - - 2013
Elevated serum uric acid levels are a frequent finding in persons with obesity, hypertension, cardiovascular and kidney disease as well as in those with the cardiorenal metabolic syndrome (CRS). The increased consumption of a fructose-rich Western diet has contributed to the increasing incidence of the CRS, obesity and diabetes especially ...
Ulu Arzu A *Department of Entomology and UC Davis Comprehensive Cancer Center, University of California, Davis, CA, - - 2013
The mechanisms underlying the anti-inflammatory and antihypertensive effects of long-chain ω-3 polyunsaturated fatty acids (ω-3 PUFAs) are still unclear. The epoxides of an ω-6 fatty acid, arachidonic acid epoxyeicosatrienoic acids also exhibit antihypertensive and anti-inflammatory effects. Thus, we hypothesized that the major ω-3 PUFAs, including eicosapentaenoic acid (EPA) and docosahexaenoic ...
Singh Surya S - - 2013
Neurolathyrism is past history in India since Lathyrus sativus (khesari dal) is no longer used as a staple. A consensus has evolved that khesari dal is harmless as part of a normal diet. L-ODAP (β-N-oxalyl-l-α-diamino propionic acid) the neurotoxic amino acid, from this pulse, is detoxified in humans but not ...
Nielsen Gorm G Cardiovascular and Renal Research, Institute for Molecular Medicine, University of Southern Denmark, Odense, - - 2013
Polyunsaturated fatty acid (PUFA)-activated two-pore domain potassium channels (K2P ) have been proposed to be expressed in the pulmonary vasculature. However, their physiological or pathophysiological roles are poorly defined. Here, we tested the hypothesis that PUFA-activated K2P are involved in pulmonary vasorelaxation and that alterations of channel expression are pathophysiologically ...
Cao Ai-Hua - - 2013
Long chain polyunsaturated fatty acids (LC-PUFAs) are hypothesized to play an important role in attention deficit/hyperactivity disorder (ADHD). This study evaluated LC-PUFAs composition in different encephalic regions by gas chromatography and its association with behaviour on the attentional set-shifting task, open field test and the Morris water maze of spontaneous ...
Rodrigo Ramón - - 2013
Abstract Oxidative stress (OS) plays a key role in the pathophysiology of essential hypertension and is associated with changes in the cell membrane fatty acid composition and fluidity. As (Na,K)-ATPase is modulated by the surrounding lipid microenvironment, lipid peroxidation could alter the interactions of this enzyme with the membrane components. ...
Kim Oh Yoen - - 2013
OBJECTIVE: We examined the association of cardiac hypertrophy or fibrosis with the phospholipid fatty acid (FA) composition of heart and kidney in hypertensive rats. DESIGN AND METHODS: Eight-week-old spontaneously hypertensive rats (SHRs) (n=8) and Wistar Kyoto rats (WKYs, n=8) as a normotensive control, were fed ad libitum for 6 weeks ...
Park Sung Kyun SK Department of Epidemiology, University of Michigan School of Public Health, Ann Arbor, MI, USA. - - 2013
Few studies have examined the association between hypertension and mercury exposure in the general population. We examined cross-sectional associations between blood (mainly methylmercury) or urinary mercury (mainly inorganic mercury) and hypertension in representative U.S. adults and effect modifications by dietary omega-3 fatty acids and serum selenium. We examined 6607 adults ...
Jeemon Panniyammakal P Centre for Chronic Disease Control, New Delhi, - - 2013
UA (uric acid) is the final product of purine metabolism in humans and is implicated in many disease conditions. Sustained hyperuricaemia has putative adverse roles in cardiovascular diseases. Despite strong evidence emerging from large epidemiological studies supporting the hypothesis that UA independently influences cardiovascular disease outcomes and mortality, a causal ...
Herrera-Meza M S - - 2013
Saturated and trans fatty acids have been associated with the risk to develop cardiovascular diseases. However, health-promoting effects are associated with consumption of anhydrous milk fat (AMF) and ruminant trans fatty acids, such as conjugated linoleic acid (CLA) and vaccenic acid (VA) contained in the lipid fraction of milk and ...
Kanbay Mehmet - - 2013
Hyperuricaemia is common in subjects with cardiovascular disease, but is not commonly considered a true risk factor. Recent studies suggest that uric acid is biologically active and can stimulate oxidative stress, endothelial dysfunction, inflammation and vasoconstriction. Epidemiological studies have found that uric acid can independently predict the development of hypertension, ...
Jeppesen Charlotte - - 2013
Polyunsaturated fatty acids are of particular interest in the nutritional therapy for diabetes, given their potential role in several pathophysiological processes related to cardiovascular disease. Both omega-3 and omega-6 fatty acids are beneficial for improving lipid profiles in healthy individuals and among type 2 diabetic patients: Supplementation with omega-3 fatty ...
Altorf-van der Kuil Wieke - - 2013
BACKGROUND: Inverse associations between dietary protein and hypertension have been reported, which may be attributed to specific amino acids. OBJECTIVE: We examined whether the intake of glutamic acid, arginine, cysteine, lysine, or tyrosine was associated with blood pressure (BP) levels (n = 3086) and incident hypertension (n = 1810) in ...
Ryu Wi-Sun - - 2013
Unlike experimental studies indicating a neuroprotective property of uric acid, clinical studies have shown that elevated levels of uric acid are associated with a risk of ischemic stroke. However, the association of uric acid with cerebral hemorrhage has seldom been tested. We aimed to elucidate the association between uric acid ...
Ma Zhiyong - - 2013
Severe acidic pH-activated chloride channel (ICl,acid) has been found in various mammalian cells. In the present study, we investigate whether this channel participates in reactions of the thoracic aorta to severe acidosis and whether it plays a role in hypertension. We measured isometric contraction in thoracic aorta rings from spontaneously ...
Kundu Arpita - - 2013
We have determined the non-synonymous Single-Nucleotide Polymorphisms (nsSNPs) of PLD2 gene and its variations in different populations to understand its role in hypertension. Out of 350 SNPs, six are found to be non-synonymous, of which two showed significant damaging effect and SNP variability with large differences among the Minor Allele ...
Gupta Prabha Nini - - 2013
The case report illustrates an acute myocardial infarction (MI) in a 41-year-old hypertensive woman possibly because of an intake of a combination of tranexamic acid and mefenamic acid for dysmenorrhoea and menorrhagia. There are multiple case reports of MI occurring in the setting of the use of antifibrinolytic agents including ...
Sham Tung-Ting - - 2013
The dried ripe seed of Raphanus sativus L., commonly known as radish seed (or Raphani Semen), is used as traditional Chinese medicine (TCM) to treat constipation, chronic tracheitis, and hypertension. The major active compounds in Raphani Semen are alkaloids, glucosinolates, brassinosteroids, and flavonoids. Fatty acids are its main nutritional contents. ...
Sedaghat Sanaz - - 2013
There are inconsistent findings on the role of hyperuricemia as an independent risk factor for chronic kidney disease (CKD). Hypertension has been implicated as a factor influencing the association between serum uric acid and CKD. In this population-based study we investigated the association between serum uric acid and decline in ...
Zhang Chun-Yan CY Department of Cardiac Surgery, Liaocheng People's Hospital of Taishan Medical University, Liaocheng, Shandong, People's Republic of - - 2013
To investigate the relationship between serum uric acid levels and pulmonary hypertension in patients with idiopathic pulmonary artery hypertension (IPAH). Serum uric acid levels were measured in 86 patients (mean [± SD] age 35.2±12.3 years; 36 men) with IPAH. Pulmonary arterial pressure and ventricular function were assessed using echocardiography. Serum ...
Bačová Barbara B Institute for Heart Research, Slovak Academy of Sciences, Dúbravská Cesta 9, P.O. Box 104, 840 05 Bratislava, - - 2013
The purpose of this study was to examine whether n-3 PUFA intake affects n-3 and n-6 FA levels in plasma and red blood cells as well as omega-3 index in old male and female spontaneously hypertensive (SHR) and healthy rats. Plasma linoleic acid and eicosapentaenoic acid increased due to n-3 ...
Kay Catherine M CM College of Natural Sciences, Bangor University, Deiniol Road, Bangor, LL57 2UW, UK. - - 2013
A nine year study was carried out on the evolution of macroscopic "acid streamer" growths in acidic, metal-rich mine water from the point of construction of a new channel to drain an abandoned underground copper mine. The new channel became rapidly colonized by acidophilic bacteria: two species of autotrophic iron-oxidizers ...
Helal Imed I Division of Renal Diseases and Hypertension, University of Colorado Denver, Aurora, CO, - - 2013
Hyperuricemia has been implicated in the development and progression of chronic kidney disease, both in animal experiments and in clinical studies. As a potentially modifiable risk factor, we examined whether serum uric acid levels correlate with early hypertension, kidney volume and progression to end-stage renal disease (ESRD) in autosomal-dominant polycystic ...
Alam Md Ashraful - - 2012
ABSTRACT:: Ferulic acid is a simple phenolic acid commonly present in cereals. In this study, changes in heart and kidney structure and function were measured in young L-NAME-treated Wistar rats and 10 month old spontaneously hypertensive rats (SHR) alone and following chronic treatment with ferulic acid (50 mg/kg/day); n=6-10; *p<0.05. ...
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