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Results 201 - 250 of 1147
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Stoicescu Dan F - - 2012
A novel process for the preparation of two ketomethylenic antifolates, 2-(2-{4-[(2,4-diamino-pteridin-6-ylmethyl)-amino]-phenyl}-2-oxo-ethyl) pentanedioic acid and 2-(2-{4-[(2,4-diamino-pteridin-6-ylmethyl)-methyl-amino]-phenyl}-2-oxo-ethyl) pentanedioic acid is described herein. Both compounds were compared with methotrexate as inhibitors of human dihydrofolate reductase and thymidylate synthase. The in-vitro and in-vivo results suggest that these novel antifolate inhibitors could potentially constitute effective ...
Mollan Katie K Harvard School of Public Health, Center for Biostatistics in AIDS Research, FXB Bldg, 651 Huntington Ave, Boston, MA 02115-6017, USA. - - 2012
Although specific human immunodeficiency virus type 1 (HIV-1) drug resistance mutations are well studied, little is known about cumulative amino acid changes, or how regimen and participant characteristics influence these changes. In the AIDS Clinical Trials Group randomized study A5202 of treatment-naive HIV-infected participants, cumulative HIV-1 amino acid changes from ...
Stallforth Pierre - - 2012
A chemoenzymatic synthesis of sialic acid from inexpensive N-acetyl-d-glucosamine is described. In a three-step Wittig-protection-ozonolysis strategy manno-configured aldehydes are obtained. Treatment with oxaloacetate in the presence of macrophomate synthase affords the signature α-keto-γ-hydroxy acid moiety with high diastereoselectivity.
Wolf M J - - 2012
The objective of this research was to compare the effectiveness of two application methods (dip versus spray) of 4.4% lactic acid for reducing pathogens on inoculated beef trim and in ground beef. Beef trim inoculated with cocktail mixtures of E. coli O157:H7, non-O157 Shiga toxigenic E. coli (STEC), or Salmonella ...
Demir Muammer - - 2012
Whey, a by-product of cheese manufacturing is rich in nutrients such as lactose, proteins, and mineral salts. The fungus Mortierella isabellina was used for production of oil containing γ-linoleic acid (GLA) during fermentation on deproteinized whey permeate (DP-WP) with and without lactase addition. The maximum oil concentration was 3.65g/L in ...
Park Jin-Hee - - 2012
Paclitaxel is used extensively as a chemotherapeutic agent against a broad range of tumors but often leads to the early termination of treatment due to severe toxic side effects. In this study, we hypothesized that ascorbic acid could reduce the toxic side effects without interfering with the anticancer effect of ...
Castagna Antonella - - 2013
Nutraceutical (ascorbic acid and carotenoids) and physical (colour and firmness) parameters were evaluated in two tomato genotypes (Money maker and high pigment-1) subjected to post harvest UV-B irradiation at different ripening stages (mature green and turning). UV-B treatment increased the concentration of ascorbic acid and carotenoids in Money maker flesh ...
Sun Zhao-Yong - - 2012
Fuel ethanol can be produced from bamboo by concentrated sulfuric acid hydrolysis followed by continuous ethanol fermentation. To reduce the environmental impact of this process, treatment of the stillage, reuse of the sulfuric acid and reduction of the process water used were studied. The total organic carbon (TOC) concentration of ...
Eom Dahan - - 2012
Substituted indenes can be synthesized via the Brønsted acid catalyzed cyclization of diaryl- and alkyl aryl-1,3-dienes. In this approach, treatment of symmetric or unsymmetric diaryl- and alkyl aryl-1,3-dienes with a catalytic amount of trifluoromethanesulfonic acid gives a variety of indene derivatives in good to excellent yields under mild conditions.
Sogi D S DS Department of Food Science & Technology, Guru Nanak Dev University, Amritsar 143005, - - 2012
Mango (Mangifera indica L.) is a major tropical fruit that has not been exploited for fresh-cut or minimally processed products on a scale similar to apples, pineapples, or melons. The objective of this study was to investigate the effect of infrared (IR) treatment on total phenolics, carotenoids, ascorbic acid, and ...
Meng Fancheng - - 2012
Chemical treatment using concentrated nitric acid (16 M) not only induced significant improvement of mechanical and electrical properties of carbon nanotube fibers due to the enhanced interfacial interaction but also allowed much more efficient deposition of polyaniline for developing fiber-shaped supercapacitors. After the 2 h treatment, the acidized fiber had ...
Che T M - - 2012
An experiment involving 854 crossbred pigs (20 replicate pens of 4 to 8 pigs per pen) was conducted at 8 experiment stations to determine the effects of acids in nursery pig diets and their inclusion levels on growth performance using diets and weaning ages typical of those used in the ...
Park Hui Gyu - - 2012
This study was performed to investigate the effect of high hydrostatic pressure (HHP) on the conversion of linoleic acid, conjugated linoleic acid (CLA) and α-linolenic acid (α-LNA) as substrates by Bifidobacterium breve LMC520 and to optimize the HHP condition. Cell mixture were tested under HHP in a variety of conditions ...
Barbé Florence - - 2013
This study aimed to determine the kinetics of milk protein digestion and amino acid absorption after ingestion of four dairy matrices by six minipigs: unheated or heated skim milk and corresponding rennet gels. Digestive contents and plasma samples were collected over a 7h-period after meal ingestion. Gelation of milk slowed ...
Abd-El-Maeboud Karim H I - - 2012
OBJECTIVE: To investigate whether enhancing vaginal acidity improves the success of medical abortions in the midtrimester. METHODS: A double-blind, randomized, placebo-controlled trial was conducted with 48 women with missed midtrimester abortions. Twice daily, the study participants (n=24) were treated with a 3% acetic acid gel and the controls (n=24) with ...
Niemi Piritta - - 2012
Brewer's spent grain (BSG), the major side-stream of brewing, consists of the husks and the residual parts of malts after the mashing process. BSG was enzymatically fractionated by a two-step enzymatic treatment with carbohydrate and protein degrading enzymes, which solubilized 66% of BSG. BSG contained 11% lipids, which were mostly ...
King Amanda M - - 2012
Current industry chilling practices with and without the application of 2% L-lactic acid were compared for their effectiveness at reducing levels of Salmonella, Yersinia enterocolitica, and Campylobacter coli on pork variety meats. Pork variety meats (livers, intestines, hearts, and stomachs) were inoculated individually with one of the three pathogens and ...
Li Changling - - 2012
The efficiency of treating citric acid effluent by green algae Chlorella was investigated. With the highest growth rate, Chlorella vulgaris C9-JN2010 that could efficiently remove nutrients in the citric acid effluent was selected for scale-up batch experiments under the optimal conditions, where its maximum biomass was 1.04gl(-1) and removal efficiencies ...
Rigane Ghayth G Laboratoire de Chimie Organique-Physique UR11ES74, Faculté des Sciences de Sfax, Université de Sfax, Sfax, - - 2012
A very simple method is proposed to produce hydroxytyrosol, a commercially unavailable compound with well-known biological properties which justify a potential commercial application. The 2-phase Chemlali olive pomace is selected as substrate for chemical treatment. Different conditions of chemical treatment, including concentration of acid and alkaline solutions, time and temperature, ...
Calder Beth L BL Department of Food Science & Human Nutrition, University of Maine, Orono, ME 04469-5735, USA. - - 2012
After-cooking darkening (ACD) is an inherent and undesirable trait that develops in cooked potatoes. The objective of this study was to evaluate the effectiveness of sodium acid sulfate (SAS) dip treatments compared to other antigraying treatments and a control to reduce ACD in boiled, Katahdin potatoes. Dip treatments were applied ...
Zapata Pedro Javier - - 2012
BACKGROUND: Demand for broccoli has increased due to its high content of bioactive compounds. However, broccoli is a perishable commodity with a short shelf life mainly due to dehydration, yellowing and losses of bioactive compounds. Thus, efficient treatments to preserve broccoli quality are needed. RESULTS: The effect of heat treatment ...
Valls Cristina - - 2013
Various combinations of laccases, xylanase and cellulase were used to biobleach cellulose fibres from eucalyptus. The Trametes villosa and Myceliophthora thermophila laccases were used in combination with violuric acid (VA(TvL) system) and methyl syringate (MeS(MtL) system), respectively, as mediator. A dissimilar mode of action of the two systems was found: ...
Gurtler Joshua B - - 2012
A study was conducted to identify sanitizing solutions effective at inactivating ca. 5logCFU of Salmonella enterica inoculated onto the stem scar of red round tomatoes during two-minute immersion treatments. Sixty-three antimicrobial combinations were tested. Vacuum perfusion was applied to tomatoes during selected treatments to promote infiltration of sanitizer into porous ...
Wovkulich Karen - - 2012
Improved linkages between aqueous phase transport and solid-phase reactions are needed to better predict and model transport of contaminants through the subsurface. Here we develop and apply a new method for measuring As mobilization in situ within soil columns that utilizes synchrotron-based X-ray fluorescence. By performing these measurements in situ ...
Emir Çoban Ozlem O Department of Fish Processing Technology, Faculty of Fisheries, Firat University, 23119 Elazığ, - - 2014
This study was investigated the effects of some oils on chemical, microbiological and sensory quality in vacuum packed smoked rainbow trout (Oncorhynchus mykiss W.1792) fillets. Acceptability scores for appearance, taste and odour of untreated and treated smoked trout decreased with storage time. The limit of sensory acceptance was reached after ...
Won Chan-Hee - - 2012
The treatment of hydrofluoric acid (HF) wastewater has been an important environmental issue in recent years due to the extensive use of hydrofluoric acid in the chemical and electronics industries, such as semiconductor manufacturers. Coagulation/precipitation and ion exchange technologies have been used to treat HF wastewater, but these conventional methods ...
Vallverdú-Queralt Anna - - 2013
A metabolite profiling approach was used to study the effect of moderate-intensity pulsed electric field (MIPEF) treatments on the individual polyphenol and carotenoid contents of tomato fruit after refrigeration at 4°C for 24h. The MIPEF processing variables studied were electric field strength (from 0.4 to 2.0kV/cm) and number of pulses ...
Kim Jong-Yea - - 2013
This research investigated conditions by which maize starch granule porosity and load-carrying capacity (LCC) might be enhanced via treatment with varying citric acid concentrations (0.5-1.5M), temperatures (40-60°C), and lengths of treatment (1-8h). At the lowest temperatures (40 and 50°C), citric acid treatment induced minimal physicochemical changes to granules. In contrast, ...
Arroyo J M - - 2012
The protection of sunflower meal (SFM) proteins by treatments with solutions of malic acid (1 M) or orthophosphoric acid (0.67 M) and heat was studied in a 3 × 3 Latin-square design using three diets and three rumen and duodenum cannulated wethers. Acid solutions were applied to SFM at a ...
Paull J D - - 2012
On 16 February 1845 the Reverend W. H. Browne, rector of St John's Church in Launceston, Van Diemen's Land, wrote in his journal, "My dear Wife died very suddenly almost immediately after and in consequence of taking a preparation of Hyd. Cyan. Acid prepared & supplied by Dr Pugh". This ...
Delgado Joaquín - - 2012
Rare earth elements (REE) were analyzed in surface sediments from the Guadiana Estuary (SW Iberian Pyrite Belt). NASC (North American Shale Composite) normalized REE patterns show clearly convex curvatures in middle-REE (MREE) with respect to light- and heavy-REE, indicating acid-mixing processes between fluvial waters affected by acid mine drainage (AMD) ...
El-Tayeb T S - - 2012
This study was designed to evaluate selected chemical and microbiological treatments for the conversion of certain local agro-industrial wastes (rice straw, corn stalks, sawdust, sugar beet waste and sugarcane bagasse) to ethanol. The chemical composition of these feedstocks was determined. Conversion of wastes to free sugars by acid hydrolysis varied ...
Puri Neerja - - 2012
Chemical peels are the mainstay of a cosmetic practitioner's armamentarium because they can be used to treat some skin disorders and can provide aesthetic benefit. To compare 15% TCA peel and 35% glycolic acid peel for the treatment of melasma. We selected 30 participants of melasma aged between 20 and ...
Nanjannawar Lalita G LG Lecturer, Department of Orthodontics, Bharathi Vidyapeeth Dental College and Hospital, Sangli, Maharashtra, India. - - 2012
The purpose of this study was to compare the etching effects of a self-etching primer with 37% phosphoric acid on enamel by using a scanning electron microscope. Bond strength and the site of bond failure were also determined for brackets bonded using SEP and 37% phosphoric acid. A total of ...
Wu Yue Y Department of Chemistry and Chemical Engineering, Binzhou University, Binzhou, Shandong 256603, People's Republic of - - 2012
Recently, low-molecular-weight hyaluronic acid has been reported to have novel features, such as free radical scavenging activities, antioxidant activities, promotion of excisional wound healing, etc. In the present work, degradation of native hyaluronic acid by ozone treatment was performed for preparation of low-molecular-weight hyaluronic acid. The molecular weight of native ...
Kesba Hosny H - - 2012
To investigate the effect of humic acid on nematode infected, resistant and susceptible grapes in relation to lipid peroxidation and antioxidant mechanisms on selected biochemical parameters known as proactive substances. The grape rootstocks, superior, superior/freedom and freedom were reacted differently to Meloidogyne incognita and Rotylenchulus reniformis according to rootstock progenitor. ...
Türkyılmaz Meltem - - 2012
Black carrots (BCs) are a rich source of stable anthocyanins (ACNs). The purpose of this study was to evaluate the effects of clarification and pasteurisation on ACNs of black carrot juice (BCJ). Monomeric ACNs, ACN profile and percent polymeric colour were determined during processing of BCJ. While depectinisation and bentonite ...
Paul Prodyut Kumar PK Pomology and Postharvest Technology, Faculty of Horticulture, Uttar Banga Krishi Viswavidyalaya, Pundibari, Cooch Behar, West Bengal 736 615 - - 2014
The quality and stability of osmotically pre-treated and subsequently vacuum dried pineapple cubes using three different solutes and packed in three different types of packaging materials on storage was evaluated. The experiment was laid out in completely randomized block design with two factors and three replications for each treatment. Treatment ...
Singh Pankaj - - 2012
An experiment was done to assess the effect of various physico-chemical treatments on ripening behavior and post harvest quality of mango cv. Amrapali. The experiment was planned under completely randomized design (CRD) with three replications. The treatment units was five fruits per replication. Total 14 treatments were applied. Out of ...
Licciardi Paul V - - 2012
Histone deacetylase inhibitors (HDACIs) have emerged as a new class of anticancer therapeutics. The hydroxamic acid, suberoylanilide hydroxamic acid (Vorinostat, Zolinza™), and the cyclic peptide, depsipeptide (Romidepsin, Istodax™), were approved by the U.S. Food and Drug Administration (FDA) for the treatment of cutaneous T-cell lymphoma in 2006 and 2009, respectively. ...
Yang Wen-Yu - - 2012
The patatin-related phospholipase A (pPLA) hydrolyzes membrane glycerolipids to produce monoacyl compounds and free fatty acids. Phospholipids are cleaved by pPLAIIα at the sn-1 and sn-2 positions, and galactolipids, including those containing oxophytodienoic acids, can also serve as substrates. Ablation of pPLAIIα decreased lysophosphatidylcholine and lysophosphatidylethanolamine levels, but increased free ...
Edwankar Rahul V RV Department of Chemistry & Biochemistry, University of Wisconsin-Milwaukee, Milwaukee, Wisconsin 53201, - - 2012
The development of an efficient diastereoselective method that permits rapid construction of the tetracyclic core 17 of the Strychnos-Aspidosperma alkaloids is described. Enaminone 16, synthesized in high yield, has been cyclized under the influence of a Brønsted acid to provide the core tetracyclic framework 17 of the Strychnos alkaloids in ...
Guo Li-Na - - 2012
Phytochemical investigation of the ethyl acetate extracts from root barks of Dictamnus dasycarpus led to the isolation of three new compounds, named as dasycarpusenester A (1), dasycarpusester B (2), dasycarpusacid (3). Their structures were elucidated as (2S)-4-(2,2-dimethyl-5-oxotetrahydrofuran-3-yl)-2-hydroxypent-3-enoic acid methyl ester (1), (2R)-4-(2,2-dimethyl-5-oxotetrahydrofuran-3-yl)-2-hydroxypent-3-anoic acid methyl ester (2), and (2S)-4-(2,2-dimethyl-5-oxotetrahydrofuran-3-yl)-2-hydroxypent-3-anoic acid (3), ...
Hussain Javid - - 2012
Two new pentacyclic triterpenes named kirmanoic acid (1) and kurramanoic acid (2) have been isolated from the chloroform-soluble portion of the whole plant of Nepeta clarkei Hook. The structures of the two new compounds were assigned on the basis of their (1)H and (13)C NMR spectra including two-dimensional NMR techniques ...
Zeni Ana Lúcia B - - 2012
Ferulic acid (4-hydroxy-3-methoxycinnamic acid) is a phenolic compound present in several plants with claimed beneficial effects in prevention and treatment of disorders linked to oxidative stress and inflammation. In this study, we aimed to verify the possible antidepressant-like effect of acute oral administration of ferulic acid in the forced swimming ...
Shenoy Megha - - 2012
Ant-plant interactions often are mediated by extrafloral nectar (EFN) composition that may influence plant visitation by ants. Over a 300 km range in the Indian Western Ghats, we investigated the correlation between the EFN composition of the myrmecophytic ant-plant Humboldtia brunonis (Fabaceae) and the number and species of ants visiting EFN. ...
Lavola Anu - - 2012
The Saskatoon berry is currently cultivated in many parts of the world for its suitability for various food products and due to the high content of nutrients and polyphenols. To determine the phytochemical profile of a Saskatoon plant, polyphenols from leaves, stems and berries were screened from four cultivars grown ...
Kokoska Ladislav - - 2012
In this study, we analyzed the chemical composition of volatile oils hydrodistilled from seeds of Consolida regalis, Delphinium elatum, Nigella hispanica, and N. nigellastrum using GC and GC/MS. In C. regalis, octadecenoic (77.79%) and hexadecanoic acid (8.34%) were the main constituents. Similarly, the oils from D. elatum and N. hispanica ...
Tey Ju Nie - - 2012
Effects of doping on single-walled carbon nanotubes (SWNT) networks with different metallicity are reported through the study of sheet resistance changes upon annealing and acid treatment. SWNT film with high metallic tube content is found to have relatively good chemical stability against post treatments, as demonstrated from its stable film ...
Rebane Riin - - 2012
Liquid chromatography electrospray ionization mass-spectrometry (LC-ESI-MS) was used to analyze 9-fluorenylmethylmethoxycarbonyl chloride (Fmoc-Cl) and diethyl ethoxymethylenemalonate (Deemm) derivatives of three amino acids and five other compounds. Influence of boric acid on their ionization was investigated and dramatic impact on the signal was observed. The strongest signal suppression (6% of signal ...
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