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Caito Samuel W SW Division of Clinical Pharmacology and Pediatric Toxicology, Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN 37232-0414, - - 2013
Methylmercury (MeHg) is a potent neurotoxin that enters mammalian cells as a conjugate with L-cysteine through L-type large neutral amino acid transporter, LAT1, by a molecular mimicry mechanism by structurally resembling L-methionine. Caenorhabditis elegans (C. elegans) has been increasingly used to study the neurotoxic effects of MeHg, but little is ...
Rossini Maurizio - - 2013
Introduction: In this article, we have summarized the specific evidence on ibandronic acid (or ibandronate) efficacy, tolerability, and feasibility acquired from trials and clinical use. Areas covered: This critical review focuses on evidence from randomized controlled clinical trials, meta-analyses, surrogate markers, bridging trials, long-term extension studies, observational studies, clinical experiences ...
Tharamapalan Jayapregasham - - 2013
To control carbonate scale formation on reverse osmosis (RO) membrane surfaces, it is common practice to add acid as a pre-treatment chemical. However, advancements in the formulation of proprietary scale inhibitors have resulted in a re-evaluation of the need to suppress the pH of RO feedwater. In this study, a ...
Beuchat Larry R - - 2013
Studies were done to evaluate the efficacy of chlorine (200 to 1,000 μg/ml), lactic acid (0.5 to 2%), levulinic acid (0.5 to 2%), sodium dodecyl sulfate (SDS, 0.05%), lactic acid plus SDS, levulinic acid plus SDS, and a mixed peroxyacid sanitizer (Tsunami 200, 40 and 80 μg/ml) in killing Salmonella ...
Zhao Ying - - 2013
The gut microbiome is known to be extensively involved in human health and disease. In order to reveal the metabolic relationship between host and microbiome, we monitored recovery of the gut microbiota composition and fecal profiles of mice after gentamicin and/or ceftriaxone treatment. This was done by employing (1)H Nuclear ...
Joo Yongho - - 2013
Aggregation and dispersion behaviours of halloysite nanotubes (HNTs) were influenced by pH. The meso- and micro-porosity of halloysite were determined by N2 gas physisorption. The blocking and opening of halloysite nanotube pores with acid, neutral, and base treatment were detected in a micro- and mesoporous matrix of tunable porosity. The ...
Nobre Maria Elizabeth Pereira - - 2013
In the present study, we evaluated omega-3 polyunsaturated fatty acid (PUFA) (consisting of 20:5n-3 and 22:6n-3) properties on inflammation and nociception. Among the in vivo tests, writhing, formalin, and hot plate tests were conducted in mice, and carrageenan-induced paw edema, peritonitis, and Hargreaves tests were performed in rats. Following the ...
Vasile Cornelia C Department of Physical Chemistry of Polymers, Romanian Academy, "Petru Poni" Institute of Macromolecular Chemistry, - - 2013
This paper is a short review on the state-of-the-art of the use of polyelectrolyte complexes containing polysaccharides for wound and burn healing and treatment using the chitosan/hyaluronic acid polyelectrolyte complex (PEC) hydrogel. PEC is suitable for wound healing because a wet treatment can be realized and both components of PEC ...
Villanueva-Suárez M José - - 2013
Okara, a byproduct of soymilk production, has been upgraded through the use of an enzymatic treatment with Ultraflo L® to give a product (okara(ET)) which has a higher content of soluble dietary fibre and an enhanced ratio of soluble: insoluble fibre than is found in okara without treatment. Polysaccharides were ...
Wang Qiang - - 2013
Effects of high-pressure treatment (100MPa to 600MPa) on lipid oxidation and composition of fatty acids in yak body fat at 4°C and 15°C were investigated for up to 20days storage. 400 and 600MPa treatments increase the level of thiobarbituric acid-reactive substances (TBARS) 335% and 400% (p<0.05), respectively. Composition analysis shows ...
Aluigi Annalisa - - 2013
Mats of wool-derived keratin nanofibre have been prepared by electrospinning solutions of keratin in formic acid at 20 and 15wt.%, and obtaining nanofibres with mean diameter of about 400 and 250nm, respectively. These mats can find applications in tissue engineering (they can mimic the native extracellular matrix) and in wastewater ...
Tse Tsz Wah - - 2013
This article reviews an old drug tranexamic acid to its new use in the treatment of melasma. Its mechanism of preventing the activation of melanocyte from UV light, hormone and injured kerationcyte through the inhibition of the plasminogen activator system will be explored. The detail usage for such indication and ...
Monteiro Rochelle C - - 2013
Melasma is a common acquired cause of facial hyperpigmentation seen predominantly among females with significant psychological and social impact. It is often recalcitrant to treatment. Several topical hypopigmenting agents have been used to combat melasma. Hydroquinone and Kojic Acid are well established monotherapeutic agents for treating melasma. This study focuses ...
Kim Dong Chan - - 2013
It is suggested that the hepatic lipid composition is more important than lipid quantity in the pathogenesis of non-alcoholic steatohepatitis. We examined whether lipoic acid (LA) could alter intrahepatic lipid composition and free cholesterol distribution. HepG2 cells were cultured with palmitic acid (PA) with and without LA. Apoptosis, changes of ...
Nairoukh Zackaria - - 2013
Terminal aromatic alkynes are converted rapidly into ketones in a regioselective manner by treatment of their microemulsions with 0.33 M mineral acid between 80 and 140 °C. Internal and aliphatic acetylenes are likewise hydrated, but require longer reaction periods. The products are easily isolated from the reaction mixtures by phase separation. Replacement ...
Villasuso Ana Laura - - 2013
Phosphatidic acid (PA) is the common lipid product in abscisic acid (ABA) and gibberellic acid (GA) response. In this work we investigated the lipid metabolism in response to both hormones. We could detect an in vivo phospholipase D activity (PLD, EC 3.1.4.4). This PLD produced [(32)P]PA (phosphatidic acid) rapidly (minutes) in ...
Jeong Han-Seob - - 2013
In this study, rapeseed cake (RSC) was used as a source of pectins due to its high carbohydrate content. Different combinations of treatments were applied to investigate the effect of combination processes on the extraction of pectin from RSC. The treatments chosen for combination were a fat removal process (FRP) ...
Hideno Akihiro - - 2013
The effects of adding trace acids in ethanol based organosolv treatment were investigated to increase the enzymatic digestibility of Japanese cypress. A high glucose yield (60%) in the enzymatic hydrolysis was obtained by treating the sample at 170°C for 45min in 50% ethanol liquor containing 0.4% hydrochloric acid. Moreover, the ...
Poiroux-Gonord Florine - - 2013
In plants, stress signals propagate to trigger distant responses and thus stress acclimation in non-exposed organs. We tested here the hypothesis that leaves submitted to photooxidative stress may influence the metabolism of nearby fruits and thus quality criteria. Leaves of orange trees (Citrus sinensis (L.) Osbeck cv. 'Navelate') were acclimated ...
Guaraldo Thais T - - 2013
New assays with HepG2 cells indicate that Indigo Carmine (IC), a dye that is widely used as additive in many food and pharmaceutical industries exhibited cytotoxic effects. This work describes the development of a bicomponent nanostructured Ti/TiO(2)/WO(3) electrode prepared by "template" method and investigates its efficiency in a photoelectrocatalytic method ...
Rubio-Senent Fátima - - 2013
A liquid phase rich in bioactive compounds, such as phenols and sugars, is obtained from olive oil waste by novel thermal treatment. Two groups of fractions with common characteristics were obtained and studied after thermal treatment, acid hydrolysis, separation by ultrafiltration and chromatography and finally by Superdex Peptide HR. In ...
Masson Serge - - 2013
Treatment with long-chain n-3 polyunsaturated fatty acids (n-3 PUFAs) can improve clinical outcomes in patients with heart failure (HF). Circulating levels of n-3 PUFA, an objective estimation of exposure, have never been measured in a large cohort of patients with HF. We measured n-3 PUFA in plasma phospholipids at baseline ...
Baumann Leslie S - - 2013
This study evaluated the tolerance and efficacy of 2 facial skin products in subjects with acne using the following acne treatments: 1) treatment A, a combination of salicylic acid, capryloyl salicylic acid, HEPES, glycolic acid, citric acid, and dioic acid, and 2) treatment B (BenzaClin&reg;, clindamycin 1% and benzoyl peroxide ...
Emam M M - - 2013
The combined effects of yeast (1 ppm) and salinity on germination, seedling growth, metabolite accumulation and antioxidant defense system of flax (Linum usitatissimum) seeds grown at 100, 200 and 300 mM NaCl were studied. In this investigation, the germination was completely inhibited at 300 mM NaCl. Moreover, salinity induced marked ...
Hu X B - - 2013
Methods were investigated for biofilm regeneration on carriers in a moving bed biofilm reactor used for vitamin C production wastewater treatment. Three ordinary chemical cleaning agents (hydrochloric acid, sodium hydroxide, and sodium hypochlorite) and physical drying were chosen for evaluation as methods for biofilm detachment. The results showed that these ...
Akiyama Kousuke - - 2013
Treatment of the ether-insoluble resin glycoside (convolvulin) fraction from seeds of Quamoclit pennata (Convolvulaceae) with indium(III) chloride in methanol provided three oligoglycosides of hydroxy fatty acid (glycosidic acid) methyl esters and two methyl glycosides, which were partially acylated by a glycosidic acid, 7S-hydroxydecanoic acid 7-O-β-D-quinovopyranoside (quamoclinic acid B) and/or two ...
Wang L X - - 2013
The changes of photosynthetic parameters, water use efficiency (WUE), fatty acid composition, chlorophyll (Chl) content, malondialdehyde (MDA) content, ATPase and acid phosphatase activities, fluoride (F) content, and leaf anatomical structure of two tea cultivars, "Pingyangtezao" (PY) and "Fudingdabai" (FD), after F treatments were investigated. The results show that net photosynthetic ...
Karimi-Yazdi Alireza A Department of Otorhinolaryngology, School of Medicine, Tehran University of Medical Sciences, Tehran, - - 2013
Otorrhea and granulation tissue in Canal Wall Down mastoidectomy (CWD) is the common problem in cholesteatoma removal and leads to many discomfort for both the patient and the physician. The main objective in CWD is creating the dry cavity, so the topical antibiotic and acetic acid in variable saturations are ...
Reid Ian R IR Faculty of Medical and Health Sciences, University of Auckland , Auckland, New - - 2013
Six patients from the phase 3 trials of zoledronic acid in Paget's disease, who had received zoledronic acid initially and had subsequently relapsed, were entered into an open re-treatment study. Following re-treatment, each patient reached similar absolute nadirs of serum alkaline phosphatase to those recorded after their first dose. No ...
Kuznetsova Tatiana T Department of Virology, National Institute for Health Development, Tallinn, - - 2013
A substantial proportion of hepatitis C virus (HCV)-1b infected patients do not response to pegylated interferon-α plus ribavirin (PegIFNα/RBV) combination therapy that was partially associated with mutations in the non-structural 5A (NS5A) protein. Analysis of NS5A polymorphisms in HCV genotype 1b pre-treatment serum samples from Estonian patients and their effect ...
Kim Hee-Young - - 2013
Waxy maize starch was dispersed (14.7% solids) in an aqueous sulfuric acid solution (3.16M), and hydrolyzed by stirring for up to 7 days at 40°C with ultrasonic treatments at different vibration amplitudes (20 and 40%) and durations (30 and 60min/day). The amount of starch nanoparticles in the hydrolyzates isolated after ...
Pálková Helena - - 2012
The effect of tetrabutylammonium (Bu(4)N(+)) and tetrapentylammonium (Pe(4)N(+)) cations on the modification of the organo-montmorillonite structure upon acid-treatment was investigated. Samples were treated with HCl for various times (2-12h). Structural changes were followed by MAS NMR spectroscopy. The (29)Si MAS NMR spectra of initial Na-saturated form (Na-SAz) showed gradual decrease ...
Poole Chris D - - 2012
BACKGROUND: There are conflicting data regarding the benefits of omega-3 (n-3) fatty acids, most recently in patients with type 2 diabetes. OBJECTIVE: Our goal was to evaluate the impact of licensed, highly purified n-3 fatty acids on all-cause mortality after myocardial infarction (MI). METHODS: This was a retrospective, matched-cohort study ...
Xia Ao - - 2012
Glutamic acid can hardly produce hydrogen via dark- or photo-fermentation without pretreatment. In this study, a novel process of acidogenic pretreatment with bacteria and zeolite treatment for NH(4)(+) removal was proposed to use glutamic acid as feedstock in photo-fermentation for efficient hydrogen production. Glutamic acid pretreated with acidogenic bacteria produces ...
Wong Banny S - - 2013
Elobixibat (formerly A3309) is a first-in-class ileal bile acid transporter (IBAT) inhibitor for treatment of chronic idiopathic constipation (CIC; syn functional constipation). CIC affects up to 25% of the general population; and up to a half are unsatisfied with current therapies. There is an unmet need for safe and effective ...
Mena Jaqueline - - 2012
Neutrophils are critical to the innate immune response; therefore, the proper function of neutrophils is critical to avoid the development of certain diseases. Linoleic acid, a polyunsaturated long-chain fatty acid, is one of the most abundant long-chain fatty acids found in the plasma of cows after giving birth. In this ...
- - 2012
BACKGROUND: Atherogenic dyslipidemia contributes substantially to the residual cardiovascular risk. The aim of this study was to examine the effects of therapeutic doses of n-3 polyunsaturated fatty acids on the three major lipid abnormalities of atherogenic dyslipidemia, i.e. hypertriacylglycerolemia, low HDL cholesterol, and increased levels of small dense LDL particles, ...
Stoicescu Dan F - - 2012
A novel process for the preparation of two ketomethylenic antifolates, 2-(2-{4-[(2,4-diamino-pteridin-6-ylmethyl)-amino]-phenyl}-2-oxo-ethyl) pentanedioic acid and 2-(2-{4-[(2,4-diamino-pteridin-6-ylmethyl)-methyl-amino]-phenyl}-2-oxo-ethyl) pentanedioic acid is described herein. Both compounds were compared with methotrexate as inhibitors of human dihydrofolate reductase and thymidylate synthase. The in-vitro and in-vivo results suggest that these novel antifolate inhibitors could potentially constitute effective ...
Mollan Katie K Harvard School of Public Health, Center for Biostatistics in AIDS Research, FXB Bldg, 651 Huntington Ave, Boston, MA 02115-6017, USA. - - 2012
Although specific human immunodeficiency virus type 1 (HIV-1) drug resistance mutations are well studied, little is known about cumulative amino acid changes, or how regimen and participant characteristics influence these changes. In the AIDS Clinical Trials Group randomized study A5202 of treatment-naive HIV-infected participants, cumulative HIV-1 amino acid changes from ...
Stallforth Pierre - - 2012
A chemoenzymatic synthesis of sialic acid from inexpensive N-acetyl-d-glucosamine is described. In a three-step Wittig-protection-ozonolysis strategy manno-configured aldehydes are obtained. Treatment with oxaloacetate in the presence of macrophomate synthase affords the signature α-keto-γ-hydroxy acid moiety with high diastereoselectivity.
Wolf M J - - 2012
The objective of this research was to compare the effectiveness of two application methods (dip versus spray) of 4.4% lactic acid for reducing pathogens on inoculated beef trim and in ground beef. Beef trim inoculated with cocktail mixtures of E. coli O157:H7, non-O157 Shiga toxigenic E. coli (STEC), or Salmonella ...
Demir Muammer - - 2012
Whey, a by-product of cheese manufacturing is rich in nutrients such as lactose, proteins, and mineral salts. The fungus Mortierella isabellina was used for production of oil containing γ-linoleic acid (GLA) during fermentation on deproteinized whey permeate (DP-WP) with and without lactase addition. The maximum oil concentration was 3.65g/L in ...
Park Jin-Hee - - 2012
Paclitaxel is used extensively as a chemotherapeutic agent against a broad range of tumors but often leads to the early termination of treatment due to severe toxic side effects. In this study, we hypothesized that ascorbic acid could reduce the toxic side effects without interfering with the anticancer effect of ...
Castagna Antonella - - 2013
Nutraceutical (ascorbic acid and carotenoids) and physical (colour and firmness) parameters were evaluated in two tomato genotypes (Money maker and high pigment-1) subjected to post harvest UV-B irradiation at different ripening stages (mature green and turning). UV-B treatment increased the concentration of ascorbic acid and carotenoids in Money maker flesh ...
Sun Zhao-Yong - - 2012
Fuel ethanol can be produced from bamboo by concentrated sulfuric acid hydrolysis followed by continuous ethanol fermentation. To reduce the environmental impact of this process, treatment of the stillage, reuse of the sulfuric acid and reduction of the process water used were studied. The total organic carbon (TOC) concentration of ...
Eom Dahan - - 2012
Substituted indenes can be synthesized via the Brønsted acid catalyzed cyclization of diaryl- and alkyl aryl-1,3-dienes. In this approach, treatment of symmetric or unsymmetric diaryl- and alkyl aryl-1,3-dienes with a catalytic amount of trifluoromethanesulfonic acid gives a variety of indene derivatives in good to excellent yields under mild conditions.
Sogi D S - - 2012
Mango (Mangifera indica L.) is a major tropical fruit that has not been exploited for fresh-cut or minimally processed products on a scale similar to apples, pineapples, or melons. The objective of this study was to investigate the effect of infrared (IR) treatment on total phenolics, carotenoids, ascorbic acid, and ...
Meng Fancheng - - 2012
Chemical treatment using concentrated nitric acid (16 M) not only induced significant improvement of mechanical and electrical properties of carbon nanotube fibers due to the enhanced interfacial interaction but also allowed much more efficient deposition of polyaniline for developing fiber-shaped supercapacitors. After the 2 h treatment, the acidized fiber had ...
Che T M - - 2012
An experiment involving 854 crossbred pigs (20 replicate pens of 4 to 8 pigs per pen) was conducted at 8 experiment stations to determine the effects of acids in nursery pig diets and their inclusion levels on growth performance using diets and weaning ages typical of those used in the ...
Park Hui Gyu - - 2012
This study was performed to investigate the effect of high hydrostatic pressure (HHP) on the conversion of linoleic acid, conjugated linoleic acid (CLA) and α-linolenic acid (α-LNA) as substrates by Bifidobacterium breve LMC520 and to optimize the HHP condition. Cell mixture were tested under HHP in a variety of conditions ...
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