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Avilés C C a MERAGEM Research Group, Veterinary Faculty , University of Cordoba , Cordoba , - - 2015
Stearoyl-CoA desaturase (SCD1 gene) is an enzyme responsible for the endogenous conversion of saturated fatty acid into monounsaturated fatty acids. The objective of this study was to assess the association of a single nucleotide polymorphism (SNP) in the SCD1 gene with the fatty acid composition of beef intramuscular fat of ...
Wu Yun Y Department of Biomedical Engineering, University at Buffalo, State University of New York, 332 Bonner Hall, Buffalo, NY, 14260, USA, - - 2015
Many delivery methods have been developed to improve the therapeutic efficacy and facilitate the clinical translation of nucleic acids-based therapeutics. We present a facile microwell array to mediate the delivery of nucleic acids carried by lipoplexes, which combines the advantages of lipoplexes as an efficient carrier system, the surface mediated ...
Moukha-Chafiq Omar O a Southern Research Institute , Drug Discovery Division , Birmingham , Alabama , - - 2014
A small library of fifty-five adenosine peptide analogs was synthesized, under the Pilot Scale Library (PSL) Program of the NIH Roadmap initiative, from 2',3'-O-isopropylideneadenosine-5'-carboxylic acid 2. The coupling of amine or sulfanilamide reactants to the free 5'-carboxylic acid moiety of 2, in automated solution-phase fashion, led after acid-mediated hydrolysis to ...
Malkar Vishwabharati V VV Radiation & Photochemistry Division, Bhabha Atomic Research Centre, Trombay, Mumbai 400 085, - - 2014
Formation of silver nanoparticles in the presence of various aminipolycarboxylic acids (APCAs) such as iminodiacetic acid (IDA), nitrilotriacetic acid (NTA), ethylenediaminetetraacetic acid (EDTA), N-(2-hydroxyethyl) ethylenediaminetriacetic acid (HEDTA), diethylenetriaminepentaacetic acid (DTPA), and N,N,N',N″,N‴,N‴-triethylenetetraminehexaacetic acid (TTHA) was studied. Monodispersed silver nanoparticles capped by carboxylate groups of APCAs were prepared by the reduction ...
Ueda Minoru M Laboratory of Organic Chemistry, Department of Chemistry, Tohoku University, 6-3 Aramaki-Aza Aoba, Aoba-ku, Sendai 980-8578, Japan. - - 2014
12-O-β-d-Glucopyranosyljasmonic acid (JAG, ) induces nyctinastic leaf-folding of Samanea saman. The SAR studies of revealed the unique role of its glycone moiety. Biological activity and the target affinity of were affected by the stereochemistry of the glycone moiety. JAG belongs to a unique class of ligands in which the structure ...
Jiang Nan N State Key Laboratory of Advanced Technology for Materials Synthesis and Processing, and School of Materials Science and Engineering, Wuhan University of Technology, Wuhan, 430070, China. xyyang@whut.edu.cn tian.ge@yahoo.com - - 2014
Amino acid-based biohybrids have been developed to self-assemble on the surface of desulfurizing bacteria to form nanothin and nanoporous shells. The shells not only endow the encapsulated cells with reusability, but also offer platforms to incorporate titania and magnetic nanoparticles to improve the desulfurizing activity and the separation efficiency.
Chalmers Benjamin A BA Faculty of Science and Engineering, Queensland University of Technology , P.O. Box 2434, 2 George Street, Brisbane, QLD 4001, - - 2014
We report the synthesis of a new class of molecules which are hybrids of long-lived tetramethylisoindolinoxyl (TMIO) radicals and the pyrido[1,2-a]benzimidazole (PyrImid) scaffold. These compounds represent a new lead for noncovalently binding nucleic acid probes, as they interact with nucleic acids with previously unreported C (DNA) and C/U (RNA) complementarity, ...
Yan Ziru Z School of Medicine, Zhejiang University, Hangzhou, - - 2014
The aim of this study was to investigate the transport of two kinds of bile acids by organic anion transporting polypeptide 1B3 (OATP1B3) using first-trimester trophoblasts. The mechanisms of damage to fetuses with intrahepatic cholestasis of pregnancy were investigated, providing new potential strategies for targeted therapies aimed at reducing fetal ...
Zanato Chiara C Kosterlitz Centre for Therapeutics, Institute of Medical Sciences, University of Aberdeen, Foresterhill, AB25 2ZD, Scotland, UK. - - 2014
(-)-Kainic acid potently increases stretch-induced afferent firing in muscle spindles, probably acting through a hitherto uncloned phospholipase D (PLD)-coupled mGlu receptor. Structural modification of (-)-kainic acid was undertaken to explore the C-4 substituent effect on the pharmacology related to muscle spindle firing. Three analogues were synthesised by highly stereoselective additions ...
Agasti Soumitra S Department of Chemistry, Indian Institute of Technology Bombay, Powai, Mumbai-400076, India. - - 2014
A palladium catalyzed intermolecular annulation of cinnamic acids and phenols has been achieved for the selective synthesis of 3-substituted benzofurans. Isotope labeling, competition experiments, kinetic studies, and intermediate trapping have supported a sequence of C-C bond formation and decarboxylation followed by the C-O cyclization pathway.
Li Jie - - 2014
CuInS2 nanorods and networks are interesting candidates for applications requiring efficient charge transport, such as, solar energy conversion, because of the increased electrical conductivity in elongated or interconnected nanocrystals, compared to isolated, quasi-spherical ones. However, little is known about the growth mechanisms involved in the formation of this kind of ...
Myeong Jongyun J Seoul National University College of Medicine, Korea, Republic - - 2014
Canonical transient receptor potential (TRPC) channels are Ca(2+)-permeable nonselective cation channels that are activated by a wide variety of stimuli, including G protein-coupled receptors (GPCRs). The TRPC4 channel is expressed in a punctate distribution in the membrane. To identify the regulating region of the channel trafficking to the membrane, we ...
Brett Katharina K Free University Berlin, - - 2014
S-acylation of hemagglutinin (HA), the main glycoprotein of Influenza viruses, is an essential modification required for virus replication. Using mass spectrometry we have previously demonstrated specific attachment of acyl chains to individual acylation sites. Whereas the two cysteines in the cytoplasmic tail of HA contain only palmitate, stearate is exclusively ...
Insaward Anchana - - 2014
This study aimed to explore the effect of phenolic acid addition on properties of soy protein film. Ferulic (FE), caffeic (CA) and gallic (GA) acids as well as their oxidized products were used in this study. Phenolic acid addition was found to pose a significant effect (p≤0.05) on mechanical properties ...
Manjappa Kiran B KB Department of Chemistry, Tunghai University , No. 1727, Sec. 4, Taiwan Boulevard, Xitun District, Taichung City 40704, Taiwan, Republic of - - 2014
A microwave-promoted, metal- and catalyst-free decarboxylative α,β-difunctionlization of secondary α-amino acids via a pseudo-four-component coupling of proline, aldehyde, and 1,3-diketone to generate multifunctionalized pyrano[2,3-b]pyrrole and pyrrolizinone derivatives is reported.
He Sha S Beijing Engineering Research Center for BioNanotechnology & CAS Key Laboratory for Biological Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology, Beijing 100190, China. xingyujiang@nanoctr.cn - - 2014
This work develops a high-throughput, high-efficiency and straightforward microfluidic blotting method for analyzing proteins and nucleic acids. Sample solutions containing antibodies (for protein detection) or hybridization probes (for nucleic acid detection) are introduced into the parallel, serpentine microchannels to specifically recognize the immobilized targets on the substrate, achieving the identification ...
Ercan Onur O Kluyver Centre for Genomics of Industrial Fermentation, P.O. Box 5057, 2600 GA Delft, The Netherlands Top Institute Food and Nutrition, Nieuwe Kanaal 9A, 6709 PA Wageningen, The Netherlands Laboratory of Microbiology, Wageningen University, P.O. Box 8033, 6700 EJ Wageningen, The Netherlands NIZO food research, P.O. Box 20, 6710 BA Ede, The - - 2014
This paper describes the molecular and metabolic adaptations of Lactococcus lactis during the transition from a growing to a near-zero growth state using carbon-limited retentostat cultivation. Transcriptomic analyses revealed that metabolic patterns shifted between lactic- and mixed-acid fermentation during retentostat cultivation, which appeared to be controlled at the transcription level ...
Zaprasis Adrienne A Philipps-University Marburg, Department of Biology, Laboratory for Microbiology, Karl-von-Frisch-Str. 8, D-35043 Marburg, - - 2014
The data presented here reveal a new facet of the physiological adjustment processes through which Bacillus subtilis can derive osmostress protection. We found that the import of proteogenic (Glu, Gln, Asp, Asn, Arg) and of non-proteogenic (Orn and Cit) amino acids, and their metabolic conversion into proline enhances growth under ...
Lee Wing-Hin WH Advanced Drug Delivery Group, Faculty of Pharmacy, University of Sydney, NSW, 2006, Australia; Respiratory Technology, Woolcock Institute of Medical Research, NSW, 2006, - - 2014
Interactions between proteins and the surface of biomaterials are crucial for the biological function and success of materials implanted in the human body. In this study, hydroxyapatite (HA) with negative and positive surface charges were fabricated by functionalizing the HA surface with acidic or basic amino acids. The influence of ...
Wright Matthew E ME Department of Chemistry and ‡Tennessee Center for Botanical Medicine Research, Middle Tennessee State University , Murfreesboro, Tennessee 37132, United - - 2014
Components previously reported from Cyclocarya paliurus include the oleananes cyclocaric acids A and B, with cyclocaric acid A possessing an oxetane ring. Isolation of cyclocaric acid A from the plant extract and comparison to the literature report show that the compound originally reported as cyclocaric acid A is, in fact, ...
Nagarajan V V Department of Colloids and Materials Chemistry, CSIR-Institute of Minerals and Materials Technology, P. O. R.R.L, Bhubaneswar, India. - - 2014
Tuning the pKa in acid sensitive rhodamine spirolactam derivatives as a function of the solvent medium resulted in the selective detection of picric acid from its lower nitro phenolic analogues and a few other carboxylic acids.
Ahmar Siawash S Department of Chemistry, University of Waterloo , Waterloo, Ontario N2L 3G1, - - 2014
The conjugate alkynylation of alkylidene Meldrum's acids with alkynylalanes and alkynyl Grignards allows for the formation of propargylic all-carbon quaternary stereocenters in high yields. Ag2CO3-catalyzed intramolecular cyclization of propargylic Meldrum's acid derivatives offers a two-step entry into complex γ-alkylidene butyrolactones containing an all-carbon quaternary center at the C-4 position.
Csatayova Kristina - - 2014
A range of enantiopure polyhydroxylated piperidines, including (2R,3S,4R)-dihydroxypipecolic acid, (-)-3-epi-fagomine, (2S,3S,4R)-dihydroxyhomopipecolic acid, (2S,3R,4R)-dihydroxyhomopipecolic acid and two trihydroxy substituted homopipecolic acids, have been prepared using the diastereoselective olefinic oxidations of a range of enantiopure tetrahydropyridines as the key step. The requisite substrates were readily prepared from tert-butyl sorbate using our diastereoselective ...
Oninla Vincent O VO University of Ibadan, - - 2014
During endocytosis, membrane components move to intraluminal vesicles of the endolysosomal compartment for digestion. At the late endosomes, cholesterol is sorted out mainly by two sterol-binding proteins, NPC1 and NPC2. To study the NPC2 mediated intervesicular cholesterol transfer we developed a liposomal assay system (Abdul-Hammed et al. 2010 J. Lipid ...
Kwon Tae-Woo TW Graduated School of EEWS and KAIST Institute NanoCentury, Korea Advanced Institute of Science and Technology (KAIST), Daejeon, 305-701, - - 2014
Covalent or Noncovalent? Systematic investigation of polymeric binders incorporating Meldrum's acid reveals most critical binder properties for silicon -anodes in lithium ion batteries, that is self-healing effect facilitated by a series of noncovalent interactions.
Fei Qiang Q Department of Chemical and Bimolecular Engineering, KAIST, Daejeon, 305-701, Korea, - - 2014
Volatile fatty acids (VFAs) that can be derived from food wastes were used for microbial lipid production by Chlorella protothecoides in heterotrophic cultures. The usage of VFAs as carbon sources for lipid accumulation was investigated in batch cultures. Culture medium, culture temperature, and nitrogen sources were explored for lipid production ...
Guo Zhongpeng Z Department of Chemical and Biological Engineering, Industrial Biotechnology, Chalmers University of Technology, SE-412 96, Gothenburg, - - 2014
Weak acids are present in lignocellulosic hydrolysate as potential inhibitors that can hamper the use of this renewable resource for fuel and chemical production. To study the effects of weak acids on yeast growth, physiological investigations were carried out in batch cultures using glucose as carbon source in the presence ...
Ao Yu-Fei YF Beijing National Laboratory for Molecular Sciences, CAS Key Laboratory of Molecular Recognition and Function, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190 (P.R. - - 2014
Catalyzed by Rhodococcus erythropolis AJ270, a nitrile hydratase-amidase containing microbial whole-cell catalyst under mild conditions, enantioselective desymmetrizations of meso-cyclopentane-1,3-dicarbonitriles and cyclopentane-1,3-dicarboxamides were studied. Although the nitrile hydratase was found to exhibit high enzymatic activity, but low 1R enantioselectivity toward dinitriles, a number of 2,2-unsymmetrically substituted meso-cyclopentane-1,3-dicarboxamide substrates were converted by ...
Xing Su-Fang SF Shandong Key Laboratory of Water Pollution Control and Resource Reuse, School of Environmental Science and Engineering, Shandong University, Jinan, 250100, - - 2014
Bacterial biofilms are structured communities of cells enclosed in a self-produced hydrated polymeric matrix that can adhere to inert or living surfaces. D-amino acids were previously identified as self-produced compounds that mediate biofilm disassembly by causing the release of the protein component of the polymeric matrix. However, whether exogenous D-amino ...
Reichert Robert R Institute of Surface Chemistry and Catalysis, Ulm University, D-89069 Ulm, Germany. - - 2014
A novel thin-layer photoelectrochemical flow cell allowing the online mass spectrometric detection of volatile reaction products during photoelectrocatalytic reactions has been developed and applied for separating the contributions from photoelectrochemical water splitting and photoelectrooxidation of formic acid to the overall photocurrent in formic acid containing aqueous solution, using a nanocrystalline ...
Subramanian Venkataramanan V National Renewable Energy Laboratory , Golden, Colorado 80401, United - - 2014
Chlamydomonas reinhardtii is well adapted to survive under different environmental conditions due to the unique flexibility of its metabolism. Here we report metabolic pathways that are active during acclimation to anoxia, but were previously not thoroughly studied under dark, anoxic H2-producing conditions in this model green alga. Proteomic analyses, using ...
Matthaus B B a Max Rubner-Institut (MRI) Bundesforschungsinstitut für Ernährung und Lebensmittel Institut für Sicherheit und Qualität bei Getreide, Schützenberg 12 , D-32756 Detmold , - - 2014
The oil contents of safflower seeds ranged from 23.08% to 36.51%. The major fatty acid of safflower oil is linoleic acid, which accounted for 55.1-77.0% in oils, with a mean value of 70.66%. Three types of tocopherols were found in safflower oil in various amount α-tocopherol, β-tocopherol and γ-tocopherol, ranged ...
Blériot Yves Y Glycochemistry Group of "Organic Synthesis" Team, Université de Poitiers , UMR-CNRS 7285 IC2MP, Bât. B28, 4 rue Michel Brunet, TSA 51106, 86073 Poitiers Cedex 9, - - 2014
The first synthesis of 1,2-trans-homoiminosugars devised as mimics of β-d-GlcNAc and α-d-ManNAc is described. Key steps include a regioselective azidolysis of a cyclic sulfite and a β-amino alcohol skeletal rearrangement applied to a polyhydroxylated azepane. The β-d-GlcNAc derivative has been coupled to serine to deliver an iminosugar C-amino acid. The ...
Braid Jennifer L - - 2014
Phosphonic acid modification of zinc oxide (ZnO) electron transport layers in inverted P3HT:ICBA solar cells was studied to determine the effect of conjugated linkages between the aromatic and phosphonic acid attachment groups. For example, zinc oxide treated with 2,6-difluorophenylvinylphosphonic acid, having a conjugated vinyl group connecting the aromatic moiety to ...
Frömel Timo T Goethe University, Institute for Vascular Signalling, FRankfurt, Germany ; - - 2014
Significance: Cytochrome P450 (CYP) epoxygenases metabolize arachidonic acid to generate epoxyeicosatrienoic acids (EETs). The latter are biologically active and reported to act as an endothelium-derived hyperpolarizing factor as well as to affect angiogenic and inflammatory signaling pathways. Recent Advances: In addition to arachidonic acid, the CYP enzymes also metabolize the ...
Lin Chien-Yuan CY State Key Laboratory of Tree Genetics and Breeding, Northeast Forestry University, Harbin 150040, China Forest Biotechnology Group, Department of Forestry and Environmental Resources, North Carolina State University, Raleigh, North Carolina 27695, - - 2014
In a number of plant species, downregulation of 4-coumaric acid: coenzyme A ligase (4CL) can reduce lignin content. In lignin precursor (monolignol) biosynthesis during stem wood formation in Populus trichocarpa, two enzymes Ptr4CL3 and Ptr4CL5 catalyze the CoA ligation of 4-coumaric acid to 4-coumaroyl-CoA and caffeic acid to caffeoyl-CoA. CoA ...
Gesbert Gael G Université Paris Descartes, Sorbonne Paris Cité, Bâtiment Leriche. INSERM U1151 - CNRS UMR 8253, Institut Necker-Enfants Malades; Equipe 11: Pathogénie des Infections Systémiques, Paris, - - 2014
Intracellular bacterial pathogens have adapted their metabolism to optimally utilize the nutrients available in infected host cells. We recently reported the identification of an asparagine transporter required specifically for cytosolic multiplication of Francisella. In the present work, we characterized a new member of the Major Super Family (MSF) of transporters, ...
Wang Chuan C Department of Endocrinology, Qilu Hospital of Shandong University, Jinan, 250012, - - 2014
Irisin, a newly identified myokine responsible for browning of white or beige adipocytes, has been reported to be present at reduced levels in diabetic patients and associated with obesity, serum triglyceride (TG) levels, and intrahepatic TG levels. We wondered whether irisin could directly affect fatty acid and TG metabolism in ...
M J Tomy T Inter University Centre for Bioscience, Department of Biotechnology and Microbiology, Kannur University, Thalassery Campus, Kannur, 670661, - - 2014
Piperine is a secondary metabolite of black pepper. Its uses in medicine were already studied. However, its derivatives have not gained considerable attention. In the presented study, the lipoxygenase (LOX) inhibitory activity of piperine and its derivatives, piperonylic acid, piperic acid, and piperonal have been assessed and compared by enzyme ...
Chen Lili L Department of Chemistry, Huaibei Normal University, Huaibei, Anhui 235000, P. R. China. - - 2014
A new protocol for Ru-catalyzed decarboxylative cyclization of mandelic acids with acrylates was established, which allows efficient construction of the phthalide skeleton. Interestingly, this reaction underwent a decarboxylative process, in which only divinylation was observed, and the subsequent cyclization led to the formation of phthalides.
Wei Chenyu - - 2014
Flip-flop of protonated oleic acid molecules dissolved at two different concentrations in membranes made of 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine is studied with the aid of molecular dynamics simulations at a time scale of several microseconds. Direct, single-molecule flip-flop events are observed at this time scale, and the flip-flop rate is estimated at 0.2 ...
Krause André A Institute of Pharmacy and Molecular Biotechnology, Heidelberg University, Im Neuenheimer Feld 364, 69120 - - 2014
An optimized catalyst system of [Pd2 (dba)3 ] and AsPh3 efficiently catalyzes the Stille reaction between a diverse set of functionalized stannanes and halogenated mono-, di- and oligonucleotides. The methodology allows for the facile conjugation of short and long nucleic acid molecules with moieties that are not compatible with conventional ...
Baker Jillian Glenda JG University of Nottingham - - 2014
Salmeterol is a long-acting β2-agonist, widely used as an inhaled treatment for asthma and COPD. It has very high β2-affinity (log KD -8.95) and is very selective for the β2-adrenoceptor (1000-fold selectivity over the β1-adrenoceptor). This study used a mutagenesis approach to determine the exact amino acids in the human ...
Feng Jingwei J School of Civil Engineering, Hefei University of Technology, Hefei, 230009, - - 2014
Degradation of aqueous 3,4-dichloroaniline (3,4-DCA) was conducted in a novel dielectric barrier discharge (DBD) plasma reactor. The factors affecting the degradation efficiency of 3,4-DCA and the degradation mechanism of 3,4-DCA were investigated. The experimental results indicated that the degradation efficiency of 3,4-DCA increased with increasing input power intensity, and the ...
He Yue Y Temasek Life Sciences Laboratory, 1 Research Link, 117604 Singapore Department of Biological Sciences, National University of Singapore, - - 2014
Excess fatty acids and sterols are stored as triacylglycerols and sterol esters in specialized cellular organelles, called lipid droplets. Understanding what determines the cellular amount of neutral lipids and their packaging into lipid droplets is of fundamental and applied interest. Using two species of fission yeast, we show that cycling ...
Chandran Suresh S Suresh Chandran, Department of Neonatology, KK Women's and Children's Hospital, Singapore 229899, - - 2014
The interplay between glucose metabolism and that of the two other primary nutrient classes, amino acids and fatty acids is critical for regulated insulin secretion. Mitochondrial metabolism of glucose, amino acid and fatty acids generates metabolic coupling factors (such as ATP, NADPH, glutamate, long chain acyl-CoA and diacylglycerol) which trigger ...
Vesprini Nicholas David ND Brock - - 2014
Retinoic acid, the active metabolite of Vitamin A, is important for nervous system development, regeneration as well as cognitive functions of the adult CNS. These CNS functions are all highly dependent on neuronal activity. Retinoic acid has previously been shown to induce changes in the firing properties and action potential ...
Yokoyama Takeshi - - 2014
Transthyretin (TTR) is a homo-tetrameric serum protein associated with amyloidoses such as familial amyloid polyneuropathy and senile systemic amyloidosis. The amyloid fibril formation of TTR can be inhibited through stabilization of the TTR tetramer by the binding of small molecules. In this study, we examined the inhibitory potency of caffeic ...
Huang Kewei K Department of Chemistry, ‡Department of Bioengineering, §Department of Materials and Nanoengineering, and ∥Institute of Bioscience and Bioengineering, Rice University , Houston, Texas 77005, United - - 2014
The use of photoluminescent probes for differentiating free amino acids from biomolecules containing the same amino acids is challenging. Photoluminescent probes generally present similar emission spectra when in the presence of either free-amino acids or protein containing those same amino acids. Probes based on cyclometalated iridium(III) complexes Ir(L)2(sol)2 (where L ...
Agostinelli Enzo E Istituto Pasteur-Fondazione Cenci Bolognetti Department of Biochemical Sciences 'A. Rossi Fanelli', Sapienza University of Rome and CNR, Institute of Biology and Molecular Pathology, 00185 Rome, - - 2014
Nanotechnology for cancer gene therapy is an emerging field. Nucleic acids, polyamine analogues and cytotoxic products of polyamine oxidation, generated in situ by an enzyme-catalyzed reaction, can be developed for nanotechnology-based cancer therapeutics with reduced systemic toxicity and improved therapeutic efficacy. Nucleic acid-based gene therapy approaches depend on the compaction of ...
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