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Avilés C C a MERAGEM Research Group, Veterinary Faculty , University of Cordoba , Cordoba , - - 2015
Stearoyl-CoA desaturase (SCD1 gene) is an enzyme responsible for the endogenous conversion of saturated fatty acid into monounsaturated fatty acids. The objective of this study was to assess the association of a single nucleotide polymorphism (SNP) in the SCD1 gene with the fatty acid composition of beef intramuscular fat of ...
Caputo Mariella M Department of Pharmacy, University of Salerno, Fisciano, Salerno, - - 2014
Stearoyl-CoA desaturase 1 (SCD1) is the rate limiting enzyme in unsaturated fatty acid biosynthesis. This enzyme has an important role in the regulation of hepatic lipogenesis and lipid oxidation, and alterations in these pathways may lead to several diseases. We examined, in HepG2 cell cultures, the mechanism of SCD1 regulation ...
Park Gwon Woo GW Department of Chemical and Bimolecular Engineering, KAIST, Yuseong-gu, Daejeon 305-701, - - 2014
Volatile fatty acids (VFAs) derived from waste organics were used as low cost carbon source, for high bioreactor productivity and titer, and multi-stage continuous high cell density culture (MSC-HCDC) process was employed for economic assessment of microbial lipids for biodiesel production. The simulation study used a lipid yield of 0.3g/g-VFAs, ...
Masi Marco - - 2014
Two new phytotoxic sesquiterpenoid acids, named pyrenophoric acids B and C, were isolated together with the related pyrenophoric and abscisic acids from solid Bromus tectorum (cheatgrass) seed culture of the seed pathogen Pyrenophora semeniperda. This fungus has been proposed as a mycoherbicide for biocontrol of cheatgrass (Bromus tectorum), a Eurasian ...
Hronská Helena H Department of Biochemical Technology, Faculty of Chemical and Food Technology, Slovak University of Technology, Radlinského 9, 812 37, Bratislava, Slovakia, - - 2014
The bacterial strains of the genus Nocardia were used for the bioconversion of fumaric acid to L-malic acid. The ability of the bacterial strain Nocardia sp. CCM 4837/A to produce L-malic acid from fumaric acid was investigated under various conditions. The optimal temperature for the bioconversion was approximately 37 °C, and ...
Thulasiraman Padmamalini - - 2014
A major obstacle in the use of retinoid therapy in cancer is the resistance to this agent in tumors. Retinoic acid facilitates the growth of mammary carcinoma cells which express high levels of fatty acid-binding protein 5 (FABP5). This protein delivers retinoic acid to peroxisome proliferator-activated receptor beta/delta (PPARbeta/delta) that ...
Xu Wenlong W Key Laboratory of Colloid and Interface Chemistry, Shandong University , Ministry of Education, Jinan 250100, P. R. - - 2014
Fatty acid bilayers are usually formed due to the hydrogen bonds between the protonated carboxyl (-COOH) and the deprotonated carboxylate (-COO(-)). Therefore, the formation of the bilayers must be at the pH around the pKa of the fatty acid, which is a narrow pH range (mostly about 7-9). Fatty acid ...
Hwang Buyng Su BS Department of Marine Biotechnology, Kunsan National University , Jeonbuk, 573-701, South - - 2014
Acuminolide A (1), along with pectenotoxin II (PTX-2), dinophysistoxin I (DTX-1), okadaic acid (OA), and 7-epi-PTX-2 seco acid, was isolated from a large-scale cultivation of the dinoflagellate Dinophysis acuminata. The new 33-membered macrolide 1 was characterized by detailed analysis of 2D NMR and MS data. Its relative stereochemistry was elucidated ...
Seo Min-Ju MJ Department of Bioscience and Biotechnology, Konkuk University, 1 Hwayang-dong, Gwangjin-Gu, Seoul, 143-701, Republic of - - 2014
The optimal conditions for the production of 5,8-dihydroxy-9(Z)-octadecenoic acid (5,8-diHOME) from oleic acid by whole recombinant Escherichia coli cells expressing diol synthase from Aspergillus nidulans were 40 °C, pH 7.5, 10 % (v/v) dimethyl sulfoxide, 35 g cells l(-1), and 12 g oleic acid l(-1) at 250 rpm in a 250 ml baffled flask. Under these ...
Maeda Dean Yoshimasa - - 2014
The G protein-coupled chemokine receptors CXCR1 and CXCR2 play key roles in inflammatory diseases and carcinogenesis. In inflammation, they activate and recruit polymorphonuclear cells (PMNs) through binding of the chemokines CXCL1 (CXCR1) and CXCL8 (CXCR1 and CXCR2). Structure-activity studies that examined the effect of a novel series of S-substituted 6-mercapto-N-phenyl-nicotinamides ...
Zhang Quanxuan - - 2014
A new simple and practical protocol for scalable synthesis of a novel library of propargylated and PEGylated alpha-hydroxy acids towards the preparation of 'clickable' polylactides was described. The overall synthesis starting from readily available propargyl alcohol, bromoacetaldehyde diethyl acetal and OEGs or PEGs was developed as a convenient procedure with ...
McCune Jade A JA QUILL, The Queen's University of Belfast, Belfast, BT9 5AG, UK. - - 2014
Gutmann Acceptor Number (AN) values have been determined for Brønsted acid-ionic liquid mixtures, over a wide compositional range. Four systems of general formula [C2mim][A]-HA (A(-) = bistriflamide, [NTf2](-); triflate, [OTf](-); mesylate, [OMs](-); or acetate, [OAc](-), [C2mim](+) = 1-ethyl-3-methylimidazolium cation) were studied. A library of Brønsted acidic systems of varying acidity ...
Popeijus Herman E HE Department of Human Biology, NUTRIM School for Nutrition, Toxicology and Metabolism, Maastricht University, PO Box 616, 6200 MD, Maastricht, The - - 2014
Fatty acids regulate PPARα activity, however, most studies evaluated the binding ability of fatty acids to PPARα, which does not necessarily results in PPARα transactivation. We therefore examined dose-response relationships between fatty acids and PPARα transactivation in HepG2 cells. Secretion of apoA-I protein as-well-as CPT1, ACO, and PPARα mRNA expression, ...
Iqbal Zeeshan Z Institute of Molecular Sciences & Bioinformatics, Lahore, - - 2014
Several models that predict where post-translational modifications are likely to occur and formulate the corresponding association rules are available to analyze the functional potential of a protein sequence, but an algorithm incorporating the functional groups of the involved amino acids in the sequence analyses process is not yet available. In ...
Morales-delaRosa Silvia S Sustainable Energy and Chemistry Group (EQS), Instituto de Catálisis y Petroleoquímica, CSIC, Marie Curie, 2 Cantoblanco, 28049 Madrid (Spain) - - 2014
This work describes a relatively simple methodology for efficiently deconstructing cellulose into monomeric glucose, which is more easily transformed into a variety of platform molecules for the production of chemicals and fuels. The approach undertaken herein first involves the dissolution of cellulose in an ionic liquid (IL), followed by a ...
Wang Zhongqiang Z William G. Lowrie Department of Chemical & Biomolecular Engineering, The Ohio State University, 140 W. 19th Ave, Columbus, OH43210, - - 2014
Propionic acid is an important chemical with wide applications and its production via fermentation is of great interest. However, economic production of bio-based propionic acid requires high product titer, yield, and productivity in the fermentation. A highly efficient and stable high cell density (HCD) fermentation process with cell recycle by ...
Yuan Lin L Department of Human Nutritional Sciences, University of Manitoba, Winnipeg, Manitoba, R3T 2N2, - - 2014
Alkali/acid-pretreated canola meal and mustard bran were subjected to endo-1,4-β-xylanase (T. longibrachiatum) hydrolysis for oligosaccharide production. Pretreatments significantly (α = 0.05) increased the relative content of pentose sugars, especially in alkali-pretreated canola meal (∼44 %) and mustard bran (∼72 %). The amounts of pentosan (g/100 g) in acid- and alkali-pretreated canola meal were 7.50 and ...
Barros Stephanie A SA Department of Chemistry, University of Pennsylvania, 231 South 34th Street, Philadelphia, PA 19104 - - 2014
The modulation of nucleic acids by small molecules is an essential process across the kingdoms of life. Targeting nucleic acids with small molecules represents a significant challenge at the forefront of chemical biology. Nucleic acid junctions are ubiquitous structural motifs in nature and in designed materials. Herein, we describe a ...
Duca Frank A FA Toronto General Research Institute and Department of Medicine, UHN, Toronto, Canada, M5G - - 2014
The ability to properly sense both ingested and circulating nutrients is crucial for the maintenance of metabolic homeostasis. As such, both the gastrointestinal tract and the hypothalamus have demonstrated the capacity to sense and effectively respond to nutrients, such as fatty acids, to control food intake and glucose production to ...
Bryant Sarah L SL Division of Cancer Biology, Institute of Cancer Research, 237 Fulham Road, London SW3 - - 2014
The mammalian urogenital sinus (UGS) develops in a sex specific manner, giving rise to the prostate in the male and the sinus vagina in the embryonic female. Androgens, produced by the embryonic testis, have been shown to be crucial to this process. In this study we show that retinoic acid ...
Suk Seo Min M Department of Pharmacology, School of Medicine, Institute of Health Sciences, Gyeongsang National University, Jinju 660-751, - - 2014
Magnolia officinalis (MO) is a traditional Chinese herbal medicine that has been used in clinical practice to treat liver disease. The aim of this study is to examine the effects of MO on the development of nonalcoholic fatty liver in hepatocytes. Human hepatoma-derived HepG2 cells and mouse normal FL83B hepatocytes ...
Kildegaard Kanchana R KR The Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark, Kogle Allé 6, DK-2970 Hørsholm, - - 2014
Biologically produced 3-hydroxypropionic acid (3HP) is a potential source for sustainable acrylates and can also find direct use as monomer in the production of biodegradable polymers. For industrial-scale production there is a need for robust cell factories tolerant to high concentration of 3HP, preferably at low pH. Through adaptive laboratory ...
Chantranupong Lynne L Department of Biology, Whitehead Institute for Biomedical Research and Massachusetts Institute of Technology, 9 Cambridge Center, Cambridge, MA 02142, USA; Department of Biology, Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Koch Institute for Integrative Cancer Research, 77 Massachusetts Avenue, Cambridge, MA 02139, USA; Broad Institute of Harvard and Massachusetts Institute of Technology, 7 Cambridge Center, Cambridge MA 02142, - - 2014
The mechanistic target of rapamycin complex 1 (mTORC1) kinase is a major regulator of cell growth that responds to numerous environmental cues. A key input is amino acids, which act through the heterodimeric Rag GTPases (RagA or RagB bound to RagC or RagD) in order to promote the translocation of ...
Bensaad Karim K CRUK Hypoxia and Angiogenesis Group, The Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Headington, Oxford OX3 9DS, UK. Electronic address: - - 2014
An in vivo model of antiangiogenic therapy allowed us to identify genes upregulated by bevacizumab treatment, including Fatty Acid Binding Protein 3 (FABP3) and FABP7, both of which are involved in fatty acid uptake. In vitro, both were induced by hypoxia in a hypoxia-inducible factor-1α (HIF-1α)-dependent manner. There was a significant lipid ...
Sugiura Masaharu M Graduate School of Pharmaceutical Sciences, Kumamoto University , 5-1 Oe-honmachi, Chuo-ku, Kumamoto 862-0973, - - 2014
Enantioselective conjugate addition of styrylboronic acid to dienones was effectively catalyzed by an O-monoacyltartaric acid to afford monostyrylated products with good enantioselectivity. The RCM of the monostyrylated products using the Hoveyda-Grubbs II catalyst afforded optically active cyclopentenones, including a synthetic intermediate of the antitumor agent TEI-9826. The study shows that ...
Yang Cheng - - 2014
Background Sclerotinia sclerotiorum (Lib.) de Bary is a necrotrophic fungal pathogen which causes disease in a wide range of plants. An observed decrease in photosynthetic performance is the primary reason for the reduction of crop yield induced by S. sclerotiorum. The H2C2O4 is the main pathogenic material secreted by S. ...
Usha S S a Department of Bioinformatics , School of Life Sciences, Bharathidasan University , Tiruchirappalli 620 024 , Tamilnadu , - - 2014
We have analyzed the nonbonded interactions of the structurally similar moieties, adenine and guanine forming complexes with proteins. The results comprise (a) the amino acid-ligand atom preferences, (b) solvent accessibility of ligand atoms before and after complex formation with proteins, and (c) preferred amino acid residue atoms involved in the ...
Fernández S S Cátedra de Química Biológica, Instituto de Investigación y Tecnología en Reproducción Animal, Facultad de Ciencias Veterinarias, Universidad de Buenos Aires, Ciudad Autónoma de Buenos Aires, - - 2014
The aim of this research was to study the effect of hyaluronic acid on bovine cryopreserved spermatozoa compared with heparin as regards the variation of capacitation induction, cellular oxidative metabolism and intracellular signal induced by membrane-associated adenylate cyclase to propose hyaluronic acid as a capacitation inductor. Heparin or hyaluronic acid ...
Ogihara Kikumi K Laboratory of Pathology, School of Veterinary Medicine, Azabu - - 2014
L-type amino acid transporter 1 (LAT1), the first isotype of amino acid transport system L, transports aromatic and branched amino acids pivotal for fundamental cellular activities such cellular growth and proliferation. LAT1 expression was high only in the brain in contrast to its limited distribution and low level of expression ...
Valckx Sara D M SD Gamete Research Center, Veterinary Physiology and Biochemistry, Department of Veterinary Sciences, University of Antwerp, Wilrijk, Belgium. Electronic address: - - 2014
To study how long-term elevated non-esterified fatty acid (NEFA) concentrations, typical in metabolic disorders such as obesity or type 2 diabetes, affect murine follicular development, follicle quality, and subsequent oocyte developmental competence in vitro. Experimental study. In vitro culture setting. Female and male 13-day old, B6CBAF1 mice of proven fertility were sacrificed ...
Zschaler Josefin J Institute for Medical Physics and Biophysics, Medical Faculty, Leipzig University, Härtelstraße 16-18, 04107 Leipzig, Germany; Translational Centre for Regenerative Medicine (TRM), Leipzig University, Philipp-Rosenthal-Str. 55, 04103 Leipzig, Germany. Electronic address: - - 2014
The oxidation of polyunsaturated fatty acids to the corresponding hydroperoxide by plant and animal lipoxygenases is an important step for the generation of bioactive lipid mediators. Thereby fatty acid hydroperoxide represent a common intermediate, also in human innate immune cells, like neutrophil granulocytes. In these cells a further key component ...
Xia Jing J College of Chemistry, Jilin University , Changchun, P. R. - - 2014
Indium metal-organic frameworks (MOFs) were first used as recyclable heterogeneous Lewis acid catalysts for the synthesis of amino acid derivatives with excellent conversion yields. Moreover, exposed ether groups (Lewis basic sites) on the pore walls of In-MOF 2 could activate trimethylsilyl cyanide, forming hypervalent silicate intermediates, as proven by (29)Si ...
Hasegawa Yasuharu Y Organisch-Chemisches Institut der Universität Münster, Correnstrasse 40, 48149 Münster - - 2014
Bulky vinyl phosphanes undergo carbon-carbon coupling with aryl aldehydes with the help of the Lewis acid B(C6 F5 )3 to give isolable methylene phosphonium products. Dimesityl(vinyl)phosphane undergoes a phospha-Stork reaction with bulky enones efficiently catalyzed by B(C6 F5 )3 to eventually yield the corresponding substituted cyclobutane products.
Wu Di D Department of Pharmacology, Xi'an Jiaotong University School of Medicine, Xi'an, Shaanxi 710061, P.R. - - 2014
Atherosclerosis is a chronic inflammatory disease in the vessel, and inflammatory cytokines play an important role in the inflammatory process of atherosclerosis. A high level of free fatty acids (FFAs) produced in lipid metabolism disorders are known to participate in the formation of atherosclerosis through multiple bioactivities. As the main ...
Miyanaga Akimasa A Tokyo Institute of Technology, - - 2014
Adenylation enzymes play important roles in the biosynthesis and degradation of primary and secondary metabolites. Mechanistic insights into the recognition of α-amino acid substrates have been obtained for α-amino acid adenylation enzymes. The Asp residue is invariant and is essential for the stabilization of the α-amino group of the substrate. ...
Liu Zhaozhen Z State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, PR China; Beijing Institute for Drug Control, Beijing 100035, PR - - 2014
Eleven new acyl quinic acid derivatives, 4-O-caffeoyl-3-O-syringoylquinic acid methyl ester (1), 4-O-caffeoyl-3-O-vanilloylquinic acid (2), 4-O-caffeoyl-3-O-vanilloylquinic acid methyl ester (3), 5-O-caffeoyl-3-O-vanilloylquinic acid (4), 5-O-caffeoyl-3-O-vanilloylquinic acid methyl ester (5), 5-O-caffeoyl-3-O-sinapoylquinic acid (6), 5-O-caffeoyl-4-O-vanilloylquinic acid (7), 4-O-(7‴S, 8‴R)-glycosmisoyl-5-O-caffeoylquinic acid methyl ester (8), 4-O-(7‴S, 8‴R)-glycosmisoyl-5-O-caffeoylquinic acid (9), 3-O-(7‴S, 8‴R)-glycosmisoyl-4-O-caffeoylquinic acid (10), and 3-O-(7‴S, 8‴R)-glycosmisoyl-4-O-caffeoylquinic ...
Bosma Madeleen M Division of Preventive Medicine and Nutrition, Columbia University College of Physicians and Surgeons, New York, NY, USA; Department of Human Nutrition, Wageningen University and Research Center, Wageningen, the - - 2014
We used human cardiomyocyte-derived cells to create an in vitro model to study lipid metabolism and explored the effects of PPARγ, ACSL1 and ATGL on fatty acid-induced ER stress. Compared to oleate, palmitate treatment resulted in less intracellular accumulation of lipid droplets and more ER stress, as measured by upregulation ...
Ogawa Motohiko M Department of Virology 1, National Institute of Infectious Diseases, 1-23-1 Toyama, Shinjuku-ku, Tokyo 162-8640, Japan. Electronic address: - - 2014
Mammalian cells store excess fatty acids in the form of triglycerides within lipid droplets. The intracellular bacterium Orientia tsutsugamush is the causative agent of severe human rickettiosis. We found that O. tsutsugamushi infection induces the formation of lipid droplets in mouse L-929 fibroblasts. In infected cells, a parallel increase in ...
Figueiredo-Filho Luiz C S LC Departamento de Química, Universidade Federal de São Carlos, P.O. Box 676, 13560-970, São Carlos, SP, - - 2014
Correction for 'Exploring the origins of the apparent "electrocatalytic" oxidation of kojic acid at graphene modified electrodes' by Luiz C. S. Figueiredo-Filho et al., Analyst, 2013, 138, 4436-4442.
Al-Sabahi Bushra N - - 2014
Background Seed oils are used as cosmetics or topical treatment for wounds, allergy, dandruff, and other purposes. Natural antioxidants from plants were recently reported to delay the onset or progress of various neurodegenerative conditions. Over one thousand cultivars of Punica granatum (Punicaceae) are known and some are traditionally used to ...
Wu Junjun J Key Laboratory of Industrial Biotechnology, Ministry of Education, School of Biotechnology, Jiangnan University, 1800 Lihu Road, Wuxi, Jiangsu 214122, China Synergetic Innovation Center of Food Safety and Nutrition, 1800 Lihu Road, Wuxi, Jiangsu 214122, - - 2014
Malonyl coenzyme A (malonyl-CoA) is an important precursor for the synthesis of natural products, such as polyketides and flavonoids. The majority of this cofactor is often consumed for producing fatty acids and phospholipids, leaving only a small amount of cellular malonyl-CoA available for producing the target compound. Tuning of malonyl-CoA ...
Uraguchi Daisuke D Institute of Transformative Bio-Molecules (WPI-ITbM) and Department of Applied Chemistry, Graduate School of Engineering, Nagoya University, Furo-cho B2-3(611), Chikusa, Nagoya 464-8603, Japan. - - 2014
Highly enantioselective protonation of α-halo and alkoxy carboxylic acid-derived ketene disilyl acetals is achieved by using P-spiro chiral diaminodioxaphosphonium barfate as a Brønsted acid catalyst, where the enantiofacial discrimination by the catalyst mainly stems from the recognition of the electronic difference between two substituents on the ketene disilyl acetal.
Kaur Rimaljeet R Department of Biochemistry, Punjab Agricultural University, Ludhiana, -141004, - - 2014
The survival of a devastating pest, Helicoverpa armigera, is mainly dependent on the availability of α-amylase. Therefore, the characterization of H. armigera α-amylase and targeting it with effective inhibitors could aid in reducing its damaging effects. H. armigera gut possessed four isozymes of α-amylase. The molecular weight of major purified ...
Golani Lalit K LK Division of Medicinal Chemistry, Graduate School of Pharmaceutical Sciences, Duquesne University , 600 Forbes Avenue, Pittsburgh, Pennsylvania 15282, United - - 2014
Structure-activity relationships for cellular uptake and inhibition of cell proliferation were studied for 2-amino-4-oxo-6-substituted pyrrolo[2,3-d]pyrimidine thienoyl antifolates in which the terminal l-glutamate of the parent structure (7) was replaced by natural or unnatural amino acids. Compounds 7 and 10-13 were selectively inhibitory toward folate receptor (FR) α-expressing Chinese hamster ovary ...
Park Sung-Soo SS Department of Biological Sciences, College of Natural Sciences, Chonnam National University, South - - 2014
We show that testicular orphan nuclear receptor 4 (TR4) increases the expression of pyruvate carboxylase (PC) gene in 3T3-L1 adipocytes by direct binding to a TR4 responsive element in the murine PC promoter. While TR4 overexpression increased PC activity, oxaloacetate (OAA) and glycerol levels with enhanced incorporation of (14)C from ...
Stasyk Oleh V OV Institute of Cell Biology, National Academy of Sciences of Ukraine, Drahomanov St. 14/16, 79005 , Lviv, - - 2014
Tumor cells often exhibit specific metabolic defects due to the aberrations in oncogene-dependent regulatory and/or signaling pathways that distinguish them from normal cells. Among others, many malignant cells are deficient in biosynthesis of certain amino acids and concomitantly exhibit elevated sensitivity to deprivation of these amino acids. Although the underlying ...
Breaker Ronald R RR Department of Molecular, Cellular and Developmental Biology, and Department of Molecular Biophysics and Biochemistry, Howard Hughes Medical Institute, Yale University, Box 208103, New Haven, CT 06520, USA. Electronic address: - - 2014
RNA and DNA are simple linear polymers consisting of only four major types of subunits, and yet these molecules carry out a remarkable diversity of functions in cells and in the laboratory. Each newly discovered function of natural or engineered nucleic acids enforces the view that prior assessments of nucleic ...
Bone Simon M SM SpeeDx Pty Ltd, Eveleigh, New South Wales, 2015 Australia. - - 2014
Novel methods were developed to isothermally detect target nucleic acids and initiate signal amplification cascades. The methods utilize target-specific MNAzymes to activate universal primer molecules. These primers can subsequently promote the autonomous synthesis of DNAzymes capable of cleaving nucleic acid substrates and generating signal, which further creates the potential for ...
Mali Sachitanand M SM Department of Chemistry, Indian Institute of Science Education and Research, Dr. Homi Bhabha Road, Pune-411 008, India. - - 2014
HBTU is a standard coupling agent commonly used for the activation of free carboxylic acids during the solution and solid phase peptide synthesis. 1-Hydroxybenzotriazole (HOBt) plays a significant role in reducing the racemization during peptide synthesis; hence it is regularly used as a coupling additive. Here, we are reporting the ...
Cohen Hagai H - - 2014
With an aim to elucidate novel metabolic and transcriptional interactions associated with Met metabolism in seeds, we have produced transgenic Arabidopsis seeds expressing a feedback-insensitive form of cystathionine-γ-synthase (CGS), a key enzyme of Met synthesis. Metabolic profiling of these seeds revealed that in addition to higher levels of Met, the ...
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