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Avilés C C a MERAGEM Research Group, Veterinary Faculty , University of Cordoba , Cordoba , - - 2015
Stearoyl-CoA desaturase (SCD1 gene) is an enzyme responsible for the endogenous conversion of saturated fatty acid into monounsaturated fatty acids. The objective of this study was to assess the association of a single nucleotide polymorphism (SNP) in the SCD1 gene with the fatty acid composition of beef intramuscular fat of ...
Wu Yun Y Department of Biomedical Engineering, University at Buffalo, State University of New York, 332 Bonner Hall, Buffalo, NY, 14260, USA, - - 2015
Many delivery methods have been developed to improve the therapeutic efficacy and facilitate the clinical translation of nucleic acids-based therapeutics. We present a facile microwell array to mediate the delivery of nucleic acids carried by lipoplexes, which combines the advantages of lipoplexes as an efficient carrier system, the surface mediated ...
Moukha-Chafiq Omar O a Southern Research Institute , Drug Discovery Division , Birmingham , Alabama , - - 2014
A small library of fifty-five adenosine peptide analogs was synthesized, under the Pilot Scale Library (PSL) Program of the NIH Roadmap initiative, from 2',3'-O-isopropylideneadenosine-5'-carboxylic acid 2. The coupling of amine or sulfanilamide reactants to the free 5'-carboxylic acid moiety of 2, in automated solution-phase fashion, led after acid-mediated hydrolysis to ...
Malkar Vishwabharati V VV Radiation & Photochemistry Division, Bhabha Atomic Research Centre, Trombay, Mumbai 400 085, - - 2014
Formation of silver nanoparticles in the presence of various aminipolycarboxylic acids (APCAs) such as iminodiacetic acid (IDA), nitrilotriacetic acid (NTA), ethylenediaminetetraacetic acid (EDTA), N-(2-hydroxyethyl) ethylenediaminetriacetic acid (HEDTA), diethylenetriaminepentaacetic acid (DTPA), and N,N,N',N″,N‴,N‴-triethylenetetraminehexaacetic acid (TTHA) was studied. Monodispersed silver nanoparticles capped by carboxylate groups of APCAs were prepared by the reduction ...
Matthaus B B a Max Rubner-Institut (MRI) Bundesforschungsinstitut für Ernährung und Lebensmittel Institut für Sicherheit und Qualität bei Getreide, Schützenberg 12 , D-32756 Detmold , - - 2014
The oil contents of safflower seeds ranged from 23.08% to 36.51%. The major fatty acid of safflower oil is linoleic acid, which accounted for 55.1-77.0% in oils, with a mean value of 70.66%. Three types of tocopherols were found in safflower oil in various amount α-tocopherol, β-tocopherol and γ-tocopherol, ranged ...
Blériot Yves Y Glycochemistry Group of "Organic Synthesis" Team, Université de Poitiers , UMR-CNRS 7285 IC2MP, Bât. B28, 4 rue Michel Brunet, TSA 51106, 86073 Poitiers Cedex 9, - - 2014
The first synthesis of 1,2-trans-homoiminosugars devised as mimics of β-d-GlcNAc and α-d-ManNAc is described. Key steps include a regioselective azidolysis of a cyclic sulfite and a β-amino alcohol skeletal rearrangement applied to a polyhydroxylated azepane. The β-d-GlcNAc derivative has been coupled to serine to deliver an iminosugar C-amino acid. The ...
Braid Jennifer L - - 2014
Phosphonic acid modification of zinc oxide (ZnO) electron transport layers in inverted P3HT:ICBA solar cells was studied to determine the effect of conjugated linkages between the aromatic and phosphonic acid attachment groups. For example, zinc oxide treated with 2,6-difluorophenylvinylphosphonic acid, having a conjugated vinyl group connecting the aromatic moiety to ...
Frömel Timo T Goethe University, Institute for Vascular Signalling, FRankfurt, Germany ; - - 2014
Significance: Cytochrome P450 (CYP) epoxygenases metabolize arachidonic acid to generate epoxyeicosatrienoic acids (EETs). The latter are biologically active and reported to act as an endothelium-derived hyperpolarizing factor as well as to affect angiogenic and inflammatory signaling pathways. Recent Advances: In addition to arachidonic acid, the CYP enzymes also metabolize the ...
Wang Chuan C Department of Endocrinology, Qilu Hospital of Shandong University, Jinan, 250012, - - 2014
Irisin, a newly identified myokine responsible for browning of white or beige adipocytes, has been reported to be present at reduced levels in diabetic patients and associated with obesity, serum triglyceride (TG) levels, and intrahepatic TG levels. We wondered whether irisin could directly affect fatty acid and TG metabolism in ...
M J Tomy T Inter University Centre for Bioscience, Department of Biotechnology and Microbiology, Kannur University, Thalassery Campus, Kannur, 670661, - - 2014
Piperine is a secondary metabolite of black pepper. Its uses in medicine were already studied. However, its derivatives have not gained considerable attention. In the presented study, the lipoxygenase (LOX) inhibitory activity of piperine and its derivatives, piperonylic acid, piperic acid, and piperonal have been assessed and compared by enzyme ...
Chen Lili L Department of Chemistry, Huaibei Normal University, Huaibei, Anhui 235000, P. R. China. - - 2014
A new protocol for Ru-catalyzed decarboxylative cyclization of mandelic acids with acrylates was established, which allows efficient construction of the phthalide skeleton. Interestingly, this reaction underwent a decarboxylative process, in which only divinylation was observed, and the subsequent cyclization led to the formation of phthalides.
Wei Chenyu - - 2014
Flip-flop of protonated oleic acid molecules dissolved at two different concentrations in membranes made of 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine is studied with the aid of molecular dynamics simulations at a time scale of several microseconds. Direct, single-molecule flip-flop events are observed at this time scale, and the flip-flop rate is estimated at 0.2 ...
Krause André A Institute of Pharmacy and Molecular Biotechnology, Heidelberg University, Im Neuenheimer Feld 364, 69120 - - 2014
An optimized catalyst system of [Pd2 (dba)3 ] and AsPh3 efficiently catalyzes the Stille reaction between a diverse set of functionalized stannanes and halogenated mono-, di- and oligonucleotides. The methodology allows for the facile conjugation of short and long nucleic acid molecules with moieties that are not compatible with conventional ...
Baker Jillian Glenda JG University of Nottingham - - 2014
Salmeterol is a long-acting β2-agonist, widely used as an inhaled treatment for asthma and COPD. It has very high β2-affinity (log KD -8.95) and is very selective for the β2-adrenoceptor (1000-fold selectivity over the β1-adrenoceptor). This study used a mutagenesis approach to determine the exact amino acids in the human ...
Feng Jingwei J School of Civil Engineering, Hefei University of Technology, Hefei, 230009, - - 2014
Degradation of aqueous 3,4-dichloroaniline (3,4-DCA) was conducted in a novel dielectric barrier discharge (DBD) plasma reactor. The factors affecting the degradation efficiency of 3,4-DCA and the degradation mechanism of 3,4-DCA were investigated. The experimental results indicated that the degradation efficiency of 3,4-DCA increased with increasing input power intensity, and the ...
He Yue Y Temasek Life Sciences Laboratory, 1 Research Link, 117604 Singapore Department of Biological Sciences, National University of Singapore, - - 2014
Excess fatty acids and sterols are stored as triacylglycerols and sterol esters in specialized cellular organelles, called lipid droplets. Understanding what determines the cellular amount of neutral lipids and their packaging into lipid droplets is of fundamental and applied interest. Using two species of fission yeast, we show that cycling ...
Chandran Suresh S Suresh Chandran, Department of Neonatology, KK Women's and Children's Hospital, Singapore 229899, - - 2014
The interplay between glucose metabolism and that of the two other primary nutrient classes, amino acids and fatty acids is critical for regulated insulin secretion. Mitochondrial metabolism of glucose, amino acid and fatty acids generates metabolic coupling factors (such as ATP, NADPH, glutamate, long chain acyl-CoA and diacylglycerol) which trigger ...
Yokoyama Takeshi - - 2014
Transthyretin (TTR) is a homo-tetrameric serum protein associated with amyloidoses such as familial amyloid polyneuropathy and senile systemic amyloidosis. The amyloid fibril formation of TTR can be inhibited through stabilization of the TTR tetramer by the binding of small molecules. In this study, we examined the inhibitory potency of caffeic ...
Huang Kewei K Department of Chemistry, ‡Department of Bioengineering, §Department of Materials and Nanoengineering, and ∥Institute of Bioscience and Bioengineering, Rice University , Houston, Texas 77005, United - - 2014
The use of photoluminescent probes for differentiating free amino acids from biomolecules containing the same amino acids is challenging. Photoluminescent probes generally present similar emission spectra when in the presence of either free-amino acids or protein containing those same amino acids. Probes based on cyclometalated iridium(III) complexes Ir(L)2(sol)2 (where L ...
Kataria Yachana Y Department of Pathology, University of Illinois at Chicago, Chicago, - - 2014
Alpha-methylacyl-CoA racemase (AMACR) is an enzyme involved in fatty acid metabolism that is markedly over-expressed in virtually all prostate cancers (PCa), relative to benign tissue. One of AMACR's primary substrates, phytanic acid, is derived predominately from red meat and dairy product consumption. Epidemiological evidence suggests links between dairy/red meat intake, ...
Pandey Harshita H Department of Plant Biotechnology, Central Institute of Medicinal and Aromatic Plants (CSIR-CIMAP), Council of Scientific and Industrial Research, PO CIMAP, Kukrail Picnic Spot Road, Lucknow, 226015, - - 2014
Betulinic acid (BA), a pentacyclic triterpenoid, is gaining unmatched attention owing to its unique anti-cancer activity with selective melanoma growth inhibition without damaging normal cells. It is also well-known for its multifaceted pharmacokinetics, entailing antibacterial, antimalarial, anti-HIV and antioxidant merits. Considering the escalating demand with diminishing bioresource of this molecule, ...
Deshmukh Sharad Chandrakant - - 2014
We report, the stereoselective synthesis of alkynyl side-chain containing (2S,3R)-α-hydroxy-β-amino acid ((2S,3R)-AHBA) analogs. The Cu(I)-catalyzed reactions of (R)-glyceraldehyde acetonide and dibenzylamine with terminal alkynes provided corresponding (2S,3R)-α-amino alcohols with good-to-excellent diastereoselectivity. Subsequent chemical transformations provided easy access to the alkynyl side-chain containing (2S,3R)-AHBAs. The utility of the methodology was demonstrated ...
Lian Jiazhang J Department of Chemical and Biomolecular Engineering, University of Illinois at Urbana-Champaign, Urbana, IL, 61801, - - 2014
Fatty acids or their activated forms, fatty acyl-CoAs and fatty acyl-ACPs, are important precursors to synthesize a wide variety of fuels and chemicals, including but not limited to free fatty acids (FFAs), fatty alcohols (FALs), fatty acid ethyl esters (FAEEs), and alkanes. However, Saccharomyces cerevisiae, an important cell factory, does ...
Soria M Cecilia MC Instituto de Investigaciones para la Industria Química (INIQUI), Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Universidad Nacional de Salta (UNSa), Av. Bolivia 5150. 4400, A4402FDC, Salta, - - 2014
Bacillus cereus is an endospore-forming, Gram-positive bacterium able to cause foodborne diseases. Lactic acid bacteria (LAB) are known for their ability to synthesize organic acids and bacteriocins, but the potential of these compounds against B. cereus has been scarcely documented in food models. The present study has examined the effect ...
Webber Daniel M DM College of Medicine, Dept. of Pediatrics, Univ. of Arkansas for Medical Sciences, 13 Children's Way, Little Rock, AR, 72202, - - 2014
Heat-stabilized, defatted rice bran (HDRB) serves as a potential source of phenolic compounds which have numerous purported health benefits. An estimated 70% of phenolics present in rice bran are esterified to the arabinoxylan residues of the cell walls. Release of such compounds could provide a value-added application for HDRB. The ...
Du Yi-Qun YQ School of Biotechnology and Food Engineering, Hefei University of Technology, Hefei 230009, People's Republic of - - 2014
Umbilicaria esculenta cultivated in Huangshan Mountain (HSSE) is precious edible and medicinal lichen. In this study, four polysaccharide fractions designated as UEP1, UEP2, UEP3, and UEP4 were isolated from HSSE with water extraction at different temperature. The physico-chemical properties and immunomodulatory activities of polysaccharide fractions were investigated. The results indicated ...
Khatri Yogan Y Department of Biochemistry, Saarland University, D-66041, Saarbrücken, - - 2014
A novel naturally occurring heme-signature variant of CYP267A1 from myxobacterium Sorangium cellulosum So ce56 and its mutant L366F, the actual mimic of the 'conserved' heme-signature of cytochromes P450, were heterologously expressed in E. coli in a soluble form and purified. The UV-visible characteristics of both variants were highly similar. Although ...
Pines Gur - - 2014
Saturation point mutagenesis is employed in protein engineering and genome-editing efforts to generate libraries that span amino acid design space. Traditionally, this is accomplished by using degenerate/compressed codons such as NNK (N=A/C/G/T, K=G/T), which covers all amino acids and one stop codon. These solutions suffer from two types of redundancy: ...
Janeta Mateusz M Faculty of Chemistry, University of Wrocław, 14 F. Joliot-Curie, 50-383 Wrocław (Poland), Fax: - - 2014
Homosubstituted amido-functionalized polyoctahedral oligomeric silsesquioxanes (POSS) have been synthesized by using acyl chlorides in high yields (ca. 95 %). The method proved to be superior over "conventional" syntheses applying carboxylic acids or acid anhydrides, which are much less efficient (ca. 60 % yield). A palette of aryl and alkyl groups has been ...
Zou Xian-Guo - - 2014
In the present study, a human milk fat substitute (HMFS) enriched in medium-chain fatty acids (MCFAs) were synthesized through acidolysis reaction from Cinnamomum camphora seed oil (CCSO) with oleic acid in a solvent-free system. A commercial immobilized lipase, Lipozyme RM IM, from Rhizomucor miehei, was facilitated as a biocatalyst. Effects ...
Longo Liam M LM Department of Biomedical Sciences, Florida State University, Tallahassee, FL, - - 2014
The halophile environment has a number of compelling aspects with regard to the origin of structured polypeptides (i.e., proteogenesis) and, instead of a curious niche that living systems adapted into, the halophile environment is emerging as a candidate "cradle" for proteogenesis. In this viewpoint, a subsequent halophile-to-mesophile transition was a ...
Zhang Tian - - 2014
Recent advances in mass spectrometry have enabled proteome-wide analyses of cellular protein turnover. These studies have been greatly propelled by the development of Stable Isotope Labeling in Cell Cultures (SILAC) - a set of standardized protocols, reagents aimed at quantifying the incorporation of 15N/13C labeled amino acids into proteins. In ...
Ussar Siegfried S Institute for Diabetes and Obesity, Helmholtz Diabetes Center, Helmholtz Center Munich, Munich 85748, Germany. Electronic address: - - 2014
Fatty acids are an important class of signaling molecules regulating key aspects of whole body metabolism and physiology. In this issue, Yore et al. report a group of branched fatty acid esters of hydroxy fatty acids that regulate insulin secretion and glucose uptake through the activation of GPR120.
Lolicato Francesca - - 2014
Mobilization of fatty acids from adipose tissue during metabolic stress increases the amount of free fatty acids in blood and follicular fluid and is associated with impaired female fertility. In a previous report we described the effects of the three predominant fatty acids in follicular fluid (saturated palmitate and stearate; ...
Chu Michael M Division of Endocrinology, Diabetes, and Clinical Nutrition, Oregon Health and Science University, Portland, OR - - 2014
The spatiotemporal dynamics of triglyceride (TG) storage in unilocular adipocytes is not well understood. Here we applied ex vivo technology to study trafficking and metabolism of fluorescent fatty acid in adipose tissue explants. Live imaging revealed multiple cytoplasmic nodules surrounding the large central lipid droplet (cLD) of unilocular adipocytes. Each ...
Rautio Jarkko J School of Pharmacy, University of Eastern Finland, P.O. Box 1627, FI-70211, Kuopio, Finland. Electronic address: - - 2014
L-type amino acid transporter (LAT1) is an intriguing target for carrier-mediated transport of drugs as it is highly expressed in the blood-brain barrier and also in various types of cancer. Several studies have proposed that in order for compounds to act as LAT1 substrates they should possess both negatively charged ...
Link Lauren A LA Department of Chemistry, ‡Department of Chemical Engineering, §Department of Materials Science and Engineering, and ⊥Department of Biomedical Engineering, Texas A&M University , College Station, Texas 77842-3012, United - - 2014
Polycarbonate networks derived from the natural product quinic acid that can potentially return to their natural building blocks upon hydrolytic degradation are described herein. Solvent-free thiol-ene chemistry was utilized in the copolymerization of tris(alloc)quinic acid and a variety of multifunctional thiol monomers to obtain poly(thioether-co-carbonate) networks with a wide range ...
Low Stewart Andrew - - 2014
ABSTRACT Osteosarcoma is a malignancy of the bone that primarily affects adolescents. Current treatments retain mortality rates, which are higher than average cancer mortality rates for the adolescent age group. We designed a micellar delivery system with the aim to increase drug accumulation in the tumor and potentially reduce side ...
Qiao Yuan - - 2014
Penicillin-binding proteins (PBPs) are involved in the synthesis and remodeling of bacterial peptidoglycan (PG). Staphylococcus aureus expresses four PBPs. Genetic studies in S. aureus have implicated PBP4 in the formation of highly cross-linked PG, but biochemical studies have not reached a consensus on its primary enzymatic activity. Using synthetic Lipid ...
Teder Tarvi T Vanderbilt University, United - - 2014
Herein we characterize a generally applicable transformation of fatty acid epoxides by lipoxygenase (LOX) enzymes that results in the formation of a 5-membered endoperoxide ring in the end product. We demonstrated this transformation using soybean LOX-1 in the metabolism of 15,16-epoxy-α-linolenic acid, and murine platelet-type 12-LOX and human 15-LOX-1 in ...
Tai Jui-Ting - - 2014
We report a kinetic study of Ag nanoparticles (AgNPs) under acidic environments (i.e., pH 2.3 - ≈pH 7) and systematically investigate the impact protein interactions [i.e., bovine serum albumin (BSA) as representative] to the colloidal stability of AgNPs. Electrospray-differential mobility analysis (ES-DMA) was used to characterize the particle size distributions ...
Kamei Yuka Y Nagahama Institute of Bio-Science and Technology, - - 2014
Age-related damage accumulates and a variety of biological activities and functions deteriorate in senescent cells. However, little is known about when cellular aging behaviors begin and what cellular aging processes change. Previous research demonstrated age-related mRNA changes in budding yeast by the 18(th)-20(th) generation, which is the average replicative lifespan ...
Dubinsky Amy N AN Department of Pediatrics, University of California, San Diego, La Jolla, CA 92093, - - 2014
Macroautophagy (hereafter autophagy) is the major pathway by which macromolecules and organelles are degraded. Autophagy is regulated by the mTOR signaling pathway-the focal point for integration of metabolic information, with mTORC1 playing a central role in balancing biosynthesis and catabolism. Of the various inputs to mTORC1, the amino acid sensing pathway ...
Morrill Louis C LC EaStCHEM, School of Chemistry, University of St Andrews, North Haugh, St Andrews KY16 9ST, UK. - - 2014
Isothiourea HBTM-2.1 catalyses the Michael addition-lactonisation of 2-aryl and 2-alkenylacetic acids and α,β-unsaturated trichloromethyl ketones. Ring-opening of the resulting dihydropyranones and subsequent alcoholysis of the CCl3 ketone with an excess of methanol gives a range of diesters in high diastereo- and enantioselectivity (up to 95 : 5 dr and >99% ee). Sequential ...
Kim Minyoung M School of Pharmacy, Sungkyunkwan University, Suwon 440-746, Republic of Korea. - - 2014
Palladium-catalyzed decarboxylative acylation of highly substituted indolines with α-keto acids via C-H bond activation is described. This protocol provides efficient access to C7-carbonylated indoles known to have diverse biological profiles.
Isaac Kévin K Institut de Chimie des Substances Naturelles, CNRS UPR 2301 , 1, av. de la Terrasse, 91198 Gif-sur-Yvette, - - 2014
Phosphoric acids with planar chiral paracyclophane scaffolds have been prepared in optically pure form starting from 1,8-dibromobiphenylene, by means of a chiral phosphorodiamidate as the phosphorylating agent. Structural characterization and configurational assignment have been performed by X-ray diffraction studies. The acids promote the organocatalytic enantioselective H-transfer reduction of α-arylquinolines with ...
Lu Yingjian - - 2014
In this study, we investigated the effect of bread-making on the assay of phenolic acids from flour, dough, and bread fractions of whole and refined three wheat varieties. Comparison of efficacy of two commonly used methods for hydrolysis and extraction of phenolic acids showed that yields of total phenolic acids ...
Wang Xiao-Yin XY State Key Laboratory of Drug Research, CAS Key Laboratory of Receptor Research, the National Center for Drug Screening, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, - - 2014
Aim:TGR5 is a G protein-coupled receptor that is expressed in intestinal L-cells and stimulates glucagon-like peptide 1 (GLP-1) secretion. TGR5 may represent a novel target for the treatment of metabolic disorder. Here, we sought to design and synthesize a series of TGR5 agonists derived from the natural product betulinic acid.Methods:A ...
Zhang Yan-Ru YR Institute of Organic Chemistry, School of Chemistry and Chemical Engineering, Shandong University, Jinan 250100, P. R. China. - - 2014
We developed a ratiometric fluorescent probe for sensing HOCl based on coumarin and rhodamine acid that is directly used as a detection moiety. The probe shows high selectivity and sensitivity toward HOCl under best working conditions of myeloperoxidase by which HOCl can be generated from hydrogen peroxide and chloride.
Ogunleye Adetoro A Faculty of Science and Engineering, University of Wolverhampton, UK; - - 2014
Poly-gamma-glutamic acid (gamma-PGA) is a naturally occurring biopolymer made up of repeating units of L-glutamic acid, D-glutamic acid or both. gamma-PGA can exhibit different properties (conformational states, enantiomeric properties and molecular weight). Owing to its biodegradable, non-toxic and non-immunogenic properties, it has been successfully used in the food, medical and ...
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