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Xia Xiao-Le - - 2014
As a kind of monooxygenase with the function of catalyzing many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids, CYP2J2 is an important member of the cytochrome P450 superfamily. Located at the endoplasmic reticulum, CYP2J2 is responsible for epoxidation of endogenous arachidonic acid in cardiac ...
Hu Jiang J College of Biological Resources and Environment Science, Qujing Normal University, Sanjiang Avenue, Unicorn District, Qujing, 655011, Yunnan, China, - - 2014
Phytochemical investigation of the ethanol extract of the roots of Sanguisorba officinalis resulted in the isolation of three new triterpene glycosides, 3β-[(α-L-arabinopyranosyl)oxy]-19α,23-dihydroxyolean-12-en-28-oic acid 28-[6-O-acetyl-β-D-glucopyranosyl] ester (1), 2α,3β,19α,23-tetrahydroxyurs-12-en-28-oic acid 28-[6-O-acetyl-β-D-glucopyranosyl] ester (2), and 3β-[(α-L-arabinopyranosyl)oxy]-19α-hydroxyurs-12,20(30)-dien-28-oic acid 28-[6-O-acetyl-β-D-glucopyranosyl] ester (3). All the triterpene glycosides exhibited the significant cytotoxic potential with low IC50 values ...
Matsumata Miho M Lab. for Developmental Gene Regulation, RIKEN Brain Science Institute, Wako, Saitama 351-0198, - - 2014
The brain is rich in lipid and fatty molecules. In this review article, we focus on fatty acid binding proteins (Fabps) that bind to fatty acids such as arachidonic acid and docosahexianoic acid and transfer these lipid ligands within the cytoplasm. Among Fabp family molecules, Fabp3, Fabp5, and Fabp7 are ...
da Silva Robin P RP Metabolic and Cardiovascular Diseases Laboratory, Group on the Molecular and Cell Biology of Lipids, Department of Agricultural, Food and Nutritional Science, University of Alberta, Edmonton, Alberta, - - 2014
Non-alcoholic fatty liver disease encompasses a wide spectrum of liver damage including steatosis, non-alcoholic steatohepatitis, fibrosis and cirrhosis. We have previously reported that creatine supplementation prevents hepatic steatosis and lipid peroxidation in rats fed a high-fat diet. In this study, we employed oleate-treated McArdle RH-7777 rat hepatoma cells to investigate ...
Mendez Maxence - - 2014
The ozonolysis of submicron (150 nm) oleic acid (OL) particles has been studied in an aerosol flow tube for a wide range of initial ozone concentrations from 25 ppb to 1,100 ppb. Both reactants were monitored, as well as the four main reaction products (nonanal, azelaic acid, nonanoic acid and ...
Liu Ying Y State Key Laboratory of Material-oriented Chemical Engineering College of Biotechnology and Pharmaceutical Engineering, Nanjing Tech University, No. 30 Puzhu Road, Nanjing, 211816, - - 2014
Ensuring a suitable pH in the culture broth is a major problem in microorganism-assisted industrial fermentation of organic acids. To address this issue, we investigated the physiological changes in Rhizopus oryzae at different extracellular pH levels and attempted to solve the issue of cell shortage under low pH conditions. We ...
Anthony Josephine J Marine Biotechnology Division, ESSO-National Institute of Ocean Technology, Ministry of Earth Sciences, Government of India, Pallikaranai, Chennai, 600 100, India, - - 2014
The present study was aimed at randomly mutating the microalga, Chlorella vulgaris, in order to alter its cellular behaviour towards increased lipid production for efficient biodiesel production from algal biomass. Individual mutants from ultraviolet light (UV-1 (30 s exposure), UV-2 (60 s exposure) and UV-3 (90 s exposure)) and 5'fluorodeoxyuridine ...
Feng Xu X a Navy Medical Research Institute , No. 880 Xiangying Road, Yangpu District, Shanghai 200433 , P.R. - - 2014
Biotransformation of corosolic acid (1) by Cochliobolus lunatus and Streptomyces asparaginoviolaceus afforded four metabolites, which were identified by using (1)H NMR, (13)C NMR, DEPT, HSQC, HMBC and NOESY spectral data. Biotransformation of corosolic acid by C. lunatus R.R. Nelson & Haasis CGMCC 3.4381 produced three metabolites: 2α,3β,21β-trihydroxyurs-12-en-28-oic acid (2), 2α,3β,7β,21β-tetrahydroxy-urs-12-en-28-oic ...
Mottillo Emilio P EP McMaster University, - - 2014
Chronic activation of β3-adrenergic receptors (β3-ARs) expands the catabolic activity of both brown adipose tissue (BAT) and white adipose tissue (WAT) by engaging UCP1-dependent and UCP1 independent processes. The present work examined de novo lipogenesis (DNL) and triglyceride (TG)/glycerol dynamics in classic brown, subcutaneous 'beige', and classic WAT during sustained ...
Roy D D Nanoscience and Technology Division, DMSRDE, GT Road, Kanpur-208013 (India). - - 2014
An easily dispersible multiwalled carbon nanotube (MWCNT) derivative is prepared, and provides a platform for the synthesis of the phenyl butyric acid methyl ester (PCBM) analog. The carbene addition reaction of MWCNTs makes derivatives that are less soluble in organic solvents; by exploiting this differential solubility, PCBM analogs can be ...
Mándity István M IM Institute of Pharmaceutical Chemistry, University of Szeged, Eötvös u. 6, 6720 Szeged - - 2014
A highly efficient continuous-flow technique for the synthesis of peptides was developed. The method allows the application of only 1.5 equivalents of amino acids during coupling, while yielding virtually quantitative conversions. A mesoscale reactor was constructed which permits the use of high temperature and pressure during the synthesis. A complete ...
Ni Lixiao L Key Laboratory of Integrated Regulation and Resource Development on Shallow Lakes, MOE, School of Environment, Hohai University, 210098 Nanjing, China. Electronic address: - - 2014
The unsaturated fatty acid (linoleic acid) sustained-release microspheres were prepared with linoleic acid (LA) using alginate-chitosan microcapsule technology. These LA sustained-release microspheres had a high encapsulation efficiency (up to 62%) tested by high performance liquid chromatography with a photo diode array. The dry microspheres were characterized by a scanning electron ...
Zhang Shuo - - 2014
Lignocellulosic biomass serves as a potential alternative feedstock for production of bacterial nanocellulose (BNC), a high value-added product of bacteria such as Gluconacetobacter xylinus. The tolerance of G. xylinus to lignocellulose-derived inhibitors (formic acid, acetic acid, levulinic acid, furfural and 5-hydroxymethylfurfural) was investigated. While 100 mM of formic acid completely ...
Krenek Kimberley A - - 2014
A detailed characterization of mango pulp polyphenols and other minor phytochemicals was accomplished for the first time in the cultivar 'Keitt', whereby the identification and semi-quantification of five hydroxybenzoic acids, four cinnamic acids, two flavonoids, and six apocarotenoids was accomplished. Among the most abundant compounds were two mono-galloyl glucosides (MGG) ...
Lucken-Ardjomande Häsler Safa - - 2014
Lipid droplets are found in all cell types. Normally present at low levels in the brain, they accumulate in tumours and are associated with neurodegenerative diseases. However, little is known about the mechanisms controlling their homeostasis in the brain. We have found that the longest GRAF1 isoform, GRAF1a, is enriched ...
Jaensch Nina N Department of Biochemistry, University of Geneva Sciences II, CH1-1211, Geneva, - - 2014
Glycosylphosphatidylinositol-anchored proteins (GPI-APs) are a class of lipid-anchored proteins expressed on the cell surface of eukaryotes. The potential interaction of GPI-APs with ordered lipid domains enriched in cholesterol and sphingolipids has been proposed to function in the intracellular transport of these lipid-anchored proteins. Here we examined the biological importance of ...
Gong Tianxun T School of Electrical and Electronic Engineering, Nanyang Technological University, 50 Nanyang Avenue, Singapore 639798, Singapore; Bio-Optical Imaging Group, Singapore Bioimaging Consortium (SBIC), Agency for Science Technology and Research (A*STAR), Helios #01-02, 11 Biopolis Way, Singapore 138667, - - 2014
An ultrasensitive surface enhanced Raman spectroscopy (SERS) based sensing platform was developed to detect the mean sialic acid level on the surface of single cell with sensitivity as low as 2fmol. This platform adopted the use of an interference-free Raman tag, 4-(dihydroxyborophenyl) acetylene (DBA), which selectively binds to sialic acid ...
Zhou Dan D Department of Food Science and Engineering, College of Biological Sciences and Technology, Beijing Key Laboratory of Forest Food Process and Safety, Beijing Forestry University, Beijing 100083, - - 2015
The inhibitory effect and associated mechanisms of salicylic acid (SA) on the browning of fresh-cut Chinese chestnut were investigated. Shelled and sliced chestnuts were immersed in different concentrations of an SA solution, and the browning of the chestnut surface and interior were inhibited. The activities of polyphenol oxidase (PPO) and ...
Mandal Sudhamoy S a Central Horticultural Experiment Station (ICAR) , Aiginia, Bhubaneswar 751019 , - - 2014
Accumulation of phenolic compounds in cell walls of different plant organs leading to increased lignification is an early defence response of plants against biotic stress. The aim of this work was to delineate occurrence of cell wall-bound (CWB) phenolic compounds in Morinda citrifolia leaves. Alkaline hydrolysis of the cell wall ...
O'Doherty Patrick J - - 2014
Abstract Amino acid biosynthesis forms part of an integrated stress response against oxidants in Saccharomyces cerevisiae and higher eukaryotes. Here we show an essential role of the L-lysine biosynthesis pathway in response to the oxidative stress condition induced by the lipid oxidant - linoleic acid hydroperoxide (LoaOOH), by means of ...
Li Juan J Chongqing Key Laboratory of Neurobiology, Chongqing 400016, - - 2014
Major depressive disorder (MDD) is a debilitating mood disorder with various etiopathological hypotheses. However the pathogenesis and diagnosis are still unclear. Peripheral blood mononuclear cells (PBMCs) have been shown to be well-suited to biomarker investigation in major depressive disorder (MDD), as well as to unveil the underlying pathogenesis of MDD. ...
Pelka Karin K Institute of Innate Immunity, University Hospital, University of Bonn, 53127 Bonn, - - 2014
Sensing of nucleic acids by TLRs is crucial in the host defense against viruses and bacteria. Unc-93 homolog B1 (UNC93B1) regulates the trafficking of nucleic acid-sensing TLRs from the endoplasmic reticulum to endolysosomes, where the TLRs encounter their respective ligands and become activated. In this article, we show that a ...
Papadopoulos Giorgos N GN Department of Chemistry, University of Athens, Panepistimiopolis 15771, Athens - - 2014
A fast and efficient visible-light metal-free hydroacylation of dialkyl azodicarboxylates is described. Among a variety of activated ketones, phenyl glyoxylic acid and its ethyl ester were identified as suitable photoorganocatalysts. A range of aliphatic and aromatic aldehydes were employed, thus leading to products in high to excellent yields.
Wang Shuping S State key Laboratory of Coordination Chemistry, School of Chemistry and Chemical Engineering, Nanjing University, PR - - 2014
Dimercaptopropanesulfonic acid (DMPS) has been approved for the treatment of arsenic poisoning through promoting arsenic excretion and modulating arsenic species. To clarify how DMPS regulates the excretion of arsenic species, we investigated the effects of DMPS on the biomethylation of arsenite (As(3+)) in HepG2 cells. In the experiments, we found ...
Abdel-Atty Mona M MM Pharmaceutical Chemistry Department, Faculty of Pharmacy, Misr International University, Cairo 11431, - - 2014
In this study, five series of (E)-6-(4-substituted phenyl)-4-oxohex-5-enoic acids IIb-f (E), (E)-3-(4-(substituted)-phenyl)acrylic acids IIIa-g (E), 4-(4-(substituted)phenylamino)-4-oxobutanoic acids VIa,b,e, 5-(4-(substituted)phenylamino)-5-oxopentanoic acids VIIa,f and 2-[(4-(substituted)phenyl) carbamoyl]benzoic acids VIIIa,e were designed and synthesized. Selected compounds were screened in vitro for their cytotoxic effect on 60 human NCI tumor cell lines. Compound IIf (E) ...
Ozaki Yuya - - 2014
Proteorhodopsin (PR) is a light-driven proton pump found in marine bacteria. More than a thousand PRs are classified into blue-absorbing (λmax ~490 nm) and green-absorbing (λmax ~525 nm) PR. The color determinant is known to be at position 105, where blue-absorbing and green-absorbing PRs possess Gln and Leu, respectively. This ...
Antal Otilia - - 2014
Based on previous observations a potential resort in the therapy of the particularly radioresistant glioma would be its treatment with unsaturated fatty acids (UFAs) combined with irradiation. We evaluated the effect of different UFAs (arachidonic acid (AA), docosahexaenoic acid (DHA), gamma-linolenic acid (GLA), eicosapentaenoic acid (EPA) and oleic acid (OA)) ...
OsiƄska-Jaroszuk Monika M Department of Biochemistry, Maria Curie-Sklodowska University, Akademicka Street 19, 20-033, Lublin, Poland, - - 2014
The secretion of exopolysaccharides and oxalic acid in cultures of a white rot Ganoderma applanatum strain and a brown rot Tyromyces palustris strain were tested in terms of culture time, pH range, and temperature. The high yield of exopolysaccharides (EPS) required a moderate temperature of 28 °C for G. applanatum and ...
Holl Eda K EK Durham, N.C. From the Departments of Surgery and Pathology, Duke University Medical - - 2014
Pathologic cutaneous scarring affects over 40 million people worldwide and costs billions of dollars annually. Understanding mechanisms of fibroblast activation and granulation tissue contraction is the first step toward preventing pathologic scarring. The authors hypothesize that nucleic acids increase fibroblast activation and cause granulation tissue contraction and that sequestration of ...
Shafqatullah - Institute of Chemical Sciences, University of Peshawar, Peshawar, Pakistan / Pakistan Council of Scientific and Industrial Research Peshawar, Peshawar, - - 2014
A simple and rapid chromatographic method has been developed for the simultaneous determination of five phenolic acids including Gallic acid, Chloroganic acid, Syringic acid, Benzoic acid and Vanillic acid by HPLC with UV-VIS detector. These Phenolic acids were separated by analytical column Intersil ODS-3 C18, a gradient elution system of ...
Mustufa Muhammad Ayaz MA Bilkent University, BilGen Genetics and Biotechnology Research Center, Deptt of Molecular Biology and Genetics, Ankara, Turkey / BIPS and Department of Biochemistry, Baqai Medical University, Karachi, - - 2014
Oleanolic acid (3β-hydroxy-olean-12-en-28-oic acid; OA-01), a pentacyclic triterpene, exhibit a wide range of pharmacological and biological activities. We have isolated oleanolic acid from methanolic extract of Periploca aphylla, collected from surroundings of Karachi in the month of February. Furthermore, four known and two new C-28 amino acid conjugates of oleanolic ...
Yu Q Q Department of Chemistry and Biochemistry, Concordia University, Montreal, Canada. - - 2014
LiYF4:Tm(3+)/Yb(3+) upconverting nanoparticles (UCNPs) were functionalized with the second generation photosensitizer 5,10,15,20-tetra(m-hydroxyphenyl)chlorin (m-THPC, Temoporfin, Foscan®). m-THPC was modified using 4-(bromomethyl)benzoic acid, which induced a bathochromic shift of the m-THPC blue absorption peak. The nanoconstruct causes up to 70% cell death under 980 nm irradiation.
Ma Jun - - 2014
Eight solutions containing phosphoric acid with concentration ranging from 2 mol L-1 to neat acid have been studied by picosecond pulse radiolysis. The absorbance of the secondary radical H2PO4• formed within 7 ps of the electron pulse is observed using pulse-probe method in the visible. Kinetic analysis shows that the ...
Xu Yun - - 2014
MON 87460 (D1) maize contains a gene that expresses the cold shock protein B (CSPB) from Bacillus subtilis to confer a yield advantage when yield is limited by water availability. This study evaluated the composition of grain from the D1-containing combined-trait maize hybrids: D1 × NK603, D1 × MON 89034 ...
Bera Anupam A Academy of Scientific and Innovative Research, Gijubhai Badheka Marg, Bhavnagar-364002 - - 2014
Production of polyhydroxyalkanoates (PHAs) from Jatropha biodiesel residues, namely crude glycerol and oil cake hydrolysate, has been reported previously. Halomonas hydrothermalis (MTCC accession no. 5445; NCBI Genbank accession no. GU938192), a wild marine strain, was used in the bio-synthesis. The present study was initiated to vary the properties of the ...
Souza Joanne M M JM Laboratório de Investigação Sistemática em Biotecnologia e Biodiversidade Molecular/LabISisBio, Instituto de Ciências Exatas e Naturais, Universidade Federal do Pará, Belém, PA, - - 2014
In this study, a protocol to induce high amount of friable callus of Boerhaavia paniculata RICH and a lipidomics technique were applied to investigate the profile of lipids to relate to those present in the roots of this plant that presented anti-inflammatory activity in the crude hexane extract. The callus ...
Ramalho Suelem D SD Department of Chemistry, Federal University of São Carlos, 13565-905 São Carlos, SP, Brazil, (phone: +55-16-33518061; fax: - - 2014
Cathepsins L (catL) and B play an important role in tumor progression and have been considered promising therapeutic targets in the development of novel anticancer agents. Using a bioactivity-guided fractionation, a series of triterpenoids was identified as a new class of competitive inhibitors towards cathepsin L with affinity values in ...
Rao Y Poorna Chandra - - 2014
Fatty acids are known to influence the ability of macrophages to generate reactive oxygen species (ROS). However the effect of elaidic acid (EA, 18:1 trans fatty acid) on ROS generation is not well studied. Rat peritoneal macrophages were enriched with elaidic acid by incubating the cells with 80 1M EA. ...
Liu Li-Jia LJ School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 100102, - - 2014
To study the absorption properties and mechanism of two important components, trolline and veratric acid, from the flowers of Trollius chinensis, in order to better understand the contribution of these two compounds to the effectiveness of these flowers. The human Caco-2 cell monolayer model was employed to study the transport ...
Shen Jie - - 2014
Abstract Correlation analysis based on chromatograms and pharmacological activities is essential for understanding the effective components in complex herbal medicines. In this report, HPLC and measurement of antioxidant properties were used to describe the active ingredients of Salvia miltiorrhiza injection (SMI). HPLC results showed that tanshinol, protocatechuic aldehyde, rosmarinic acid, ...
Ahmed Dildar D Department of Chemistry, Forman Christian College (A Chartered University), Lahore 54600, Pakistan. Electronic address: - - 2014
To conduct a comparative analysis of the phenolic and flavonoid contents and anti-oxidative potential of epicarp and mesocarp of Lagenaria siceraria fruit. The dried methanolic extracts of mesocarp and epicarp of the fruit and their hexane, chloroform, ethyl acetate, n-butanolic and aqueous fractions were subjected to antioxidant assays including ferric ...
Iqbal Pervaiz P Department of Chemistry, Forman Christian College (A Chartered University), Lahore 54600, - - 2014
To evaluate antioxidant and radical scavenging activities of organic extracts from fruit, roots and aerial parts of Fagonia cretica. Shed dried and powdered plant parts were initially extracted in methanol and subsequently partitioned in n-hexane, chloroform, ethyl acetate and 1-butanol successively. Antioxidant and radical scavenging potential of the methanol extracts ...
Kim Su-Yeon SY Functional Food and Nutrition Division, Kalasalingam University, Tamil Nadu 600001, - - 2014
In the present report, the effects of blanching, steaming, and high temperature/high pressure processing (HTHP) on the amino acid contents of commonly consumed Korean root vegetables, leaf vegetables, and pulses were evaluated using an Automatic Amino Acid Analyzer. The total amino acid content of the samples tested was between 3.38 ...
Min Kyoung-Jin KJ Department of Immunology, School of Medicine, Keimyung University, Daegu, - - 2014
Carnosic acid, which is one of extract components of rosemary, has anti-inflammatory, anti-oxidant, and anti-cancer effects. However, the anti-cancer effect of carnosic acid in human renal carcinoma cells is unknown. Flow cytometry analysis was used to examine the effects of carnosic acid on apoptosis, and Asp-Glu-Val-Asp-ase activity assay kit was ...
Shirani Kobra K Department of Pharmacodynamy and Toxicology, Faculty of Pharmacy, Mashhad University of Medical Sciences, Mashhad, I. R. - - 2014
Ferula szowitsiana has been widely used for medicinal purposes around the world. The anti-oxidant effect of F. szowitsiana had been proved. The current study aims to determine the protective effects of galbanic acid, a sesquiterpene coumarin from F. szowitsiana, against hydrogen peroxide (H2O2) - induced oxidative DNA damage in human ...
Potumarthi Ravichandra R Bio Engineering and Environmental Center (BEEC), Indian Institute of Chemical Technology (CSIR), Tarnaka, Hyderabad, 500 607, India, - - 2014
Two commonly used chemical pretreatment processes, sulphuric acid, and sodium hydroxide, were tested to provide comparative performance data. A connection between solid to liquid ratio (S/L) and sugars released was observed with an increase in S/L ratio between 0.02 and 0.2. Enzymatic digestibility of 1 M of NaOH-pretreated corncobs were released ...
Yang Yishan Y Food Science & Technology Programme, Department of Chemistry, National University of Singapore, Science Drive 4, Singapore 117543, - - 2014
This study evaluated the acid and heat resistance of Salmonella Enteritidis in simulated gastric fluid (pH2.0) and during thermal treatment (54-60°C), respectively, after adaptation to lactic acid (LA) or trisodium phosphate (TSP) at various pHs (pH5.3-9.0). The changes in membrane lipid composition and expression levels of RpoS and RpoH were ...
Singer Stacy D - - 2014
BackgroundTraditional canola (Brassica napus L.; AACC, 2n¿=¿38) cultivars yield seed oil with a relatively high proportion of ¿-linolenic acid (ALA; C18:3 cis¿9,12,15), which is desirable from a health perspective. Unfortunately, due to the instability of this fatty acid, elevated levels also result in oils that exhibit a short shelf life ...
Li Xu X North Carolina State University; Purdue - - 2014
Plant secondary metabolism is an active research area because of the unique and important roles the specialized metabolites have in the interaction of plants with their biotic and abiotic environment, the diversity and complexity of the compounds and their importance to human medicine. Thousands of natural accessions of Arabidopsis thaliana ...
Cao Xiaolin X Drug Product Development, Amgen Inc., Thousand Oaks, California, - - 2014
We report, for the first time, the identification of fatty acid particles in formulations containing the surfactant polysorbate 20. These fatty acid particles were observed in multiple mAb formulations during their expected shelf life under recommended storage conditions. The fatty acid particles were granular or sand-like in morphology and were ...
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