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Pal Pratik P Department of Chemistry, Indian Institute of Technology, Kharagpur, 721302, India. - - 2014
The asymmetric total syntheses of naturally occurring resorcylic acid lactone paecilomycin E and two of its structural congeners have been reported in this article. The major highlight of the synthetic venture is the application of the late stage Mitsunobu macrolactonization method (as it is difficult to achieve the desired products ...
Rone Malena B - - 2014
Mitochondria are home to many cellular processes, including oxidative phosphorylation and fatty acid metabolism, and in steroid synthesizing cells, they are involved in cholesterol import and metabolism, which is the initiating step in steroidogenesis. The formation of macromolecular protein complexes aids in the regulation and efficiency of these mitochondrial functions, ...
Rahn Anja K K AK McGill University, Department of Food Science and Agricultural - - 2014
Chloropropanol (CP) esters are a class of thermally-induced toxicants that are mainly formed in refined edible oils. The structural diversity of these esters presents significant analytical challenges which have often been overcome through analysis of their corresponding free alcohols after a hydrolysis step. Mass spectrometry-based methodologies incorporating characteristic fragmentation patterns ...
Nagao Koji K Department of Applied Biochemistry and Food Science, Saga - - 2014
The effects on lipid metabolism of four different n-3 highly unsaturated fatty acids (n-3HUFA) including eicosapentaenoic acid (EPA, 20:5n-3), docosapentaenoic acid (DPA, 22:5n-3), docosahexaenoic acid (DHA, 22:6n-3), and tetracosahexaenoic acid (THA, 24:6n-3) were compared in the HepG2 cell model. None of the n-3HUFAs affected the viability of the cells. THA ...
Salama El-Sayed ES Department of Natural Resources and Environmental Engineering, Hanyang University, Seoul 133-791, South - - 2014
The growth of Scenedesmus obliquus improved with increase in phytohormones concentrations (10(-8)-10(-)(5)M). Indole-3-acetic acid (IAA) supported the maximum growth at 10(-5)M with 17.7×10(6)cells/mL and total fatty acid of 97.9mg/g-DCW, enhancing the growth by 1.9-fold compared to control (9.5×10(6)cells/mL). While 10(-5)M of a newly discovered phytohormone Diethyl aminoethyl hexanoate (DAH) demonstrated ...
Fiorucci Stefano S University of Perugia, Dipartimento di Scienze Chirurgiche e Biomediche, Sezione di Gastroenterologia, Nuova Facoltà di Medicina e Chirurgia , Edificio B, Piano III, Piazzale L. Severi, 1, 06132 S. Andrea delle Fratte, Perugia , Italy - - 2014
Introduction: Bile acids, the end product of cholesterol metabolism, are signaling molecules. The farnesoid X receptor (FXR) is a bile acid sensor and is part of a network of nuclear receptors that regulate bile acid homeostasis. In addition to FXR, bile acids activate other nuclear receptors (CAR, PXR and VDR), ...
Skoch Antonín A MR Unit, Department of Diagnostic and Interventional Radiology, Institute for Clinical and Experimental Medicine, Prague, Czech - - 2014
In this study, we present a method for the detection of n-3 fatty acid (n-3 FA) signals using MRS in adipose tissue in vivo. This method (called oMEGA-PRESS) is based on the selective detection of the CH3 signal of n-3 FA using the MEGA-PRESS (MEshcher-GArwood Point-RESolved Spectroscopy) J-difference editing technique. ...
Kim Donghak - - 2014
Cytochrome P450 (P450) 4A11 is the only functionally active Subfamily 4A P450 in humans. P450 4A11 catalyzes mainly ω-hydroxylation of fatty acids in liver and kidney; this process is not a major degradative pathway but at least one product, 20-hydroxyeicosatetraenoic acid, has important signaling properties. We studied catalysis by P450 ...
Ikuma Naohiko N Division of Applied Chemistry, Graduate School of Engineering, Osaka University, 2-1 Yamadaoka, Suita, Osaka 565-0871 (Japan), Fax: (+81) 6-6879-4593. - - 2014
Azafulleroid, amino-bridged [5,6]-open fullerene, has the ambident N/C basicity of the incorporated enamine moiety. Acid-catalyzed arylation of N-substituted azafulleroids proceeded via two types of initial N/C protonation to perform monoarylation or 1,4-bisarylation for the N-alkyl substituents and shuttlecock-type pentakisarylation for the N-phenyl substituent. The dramatic product change was explained by ...
Chen Xiang-Yu XY Beijing National Laboratory for Molecular Sciences, CAS Key Laboratory of Molecular Recognition and Function, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190 - - 2014
The catalytic cyclocondensation of in situ activated α,β-unsaturated carboxylic acids was developed. N-heterocyclic carbenes efficiently catalyzed the generation of α,β-unsaturated acyl azolium intermediates from α,β-unsaturated carboxylic acids via in situ generated mixed anhydrides for the enantioselective [3+2] and [3+3] cyclocondensation with α-amino ketones and alkyl(aryl)imines, respectively. The corresponding pyrrolidinones and ...
Ylikangas Henna H School of Pharmacy, University of Eastern Finland, P.O. Box 1627, 70211 Kuopio - - 2014
L-Type amino acid transporter 1 (LAT1) is a transmembrane protein expressed abundantly at the blood-brain barrier (BBB), where it ensures the transport of hydrophobic acids from the blood to the brain. Due to its unique substrate specificity and high expression at the BBB, LAT1 is an intriguing target for carrier-mediated transport ...
Paland Nicole N The Lipid Research Laboratory, Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, - - 2014
The liver is the central organ of fatty acid and triglyceride metabolism. Oxidation and synthesis of fatty acids and triglycerides is under the control of peroxisome-proliferator-activated receptors (PPAR) α. Impairment of these receptors' function contributes to the accumulation of triglycerides in the liver resulting in non-alcoholic fatty liver disease. Urokinase-type ...
Koldaş Serkan S Cankiri Karatekin University, Faculty of Natural Sciences, Department of Chemistry, 18100, Cankiri, - - 2014
A detailed phytochemical analysis of Origanum vulgare L. subsp. viride (Boiss.) Hayek was carried out and the antioxidant activities of its five different crude extracts were determined. The antiproliferative activities of the extracts were determined using the xCELLigence system (Real Time Cell Analyzer). The differences between essential oil and volatile ...
Xia Xiao-Le - - 2014
As a kind of monooxygenase with the function of catalyzing many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids, CYP2J2 is an important member of the cytochrome P450 superfamily. Located at the endoplasmic reticulum, CYP2J2 is responsible for epoxidation of endogenous arachidonic acid in cardiac ...
Hu Jiang J College of Biological Resources and Environment Science, Qujing Normal University, Sanjiang Avenue, Unicorn District, Qujing, 655011, Yunnan, China, - - 2014
Phytochemical investigation of the ethanol extract of the roots of Sanguisorba officinalis resulted in the isolation of three new triterpene glycosides, 3β-[(α-L-arabinopyranosyl)oxy]-19α,23-dihydroxyolean-12-en-28-oic acid 28-[6-O-acetyl-β-D-glucopyranosyl] ester (1), 2α,3β,19α,23-tetrahydroxyurs-12-en-28-oic acid 28-[6-O-acetyl-β-D-glucopyranosyl] ester (2), and 3β-[(α-L-arabinopyranosyl)oxy]-19α-hydroxyurs-12,20(30)-dien-28-oic acid 28-[6-O-acetyl-β-D-glucopyranosyl] ester (3). All the triterpene glycosides exhibited the significant cytotoxic potential with low IC50 values ...
Matsumata Miho M Lab. for Developmental Gene Regulation, RIKEN Brain Science Institute, Wako, Saitama 351-0198, - - 2014
The brain is rich in lipid and fatty molecules. In this review article, we focus on fatty acid binding proteins (Fabps) that bind to fatty acids such as arachidonic acid and docosahexianoic acid and transfer these lipid ligands within the cytoplasm. Among Fabp family molecules, Fabp3, Fabp5, and Fabp7 are ...
da Silva Robin P RP Metabolic and Cardiovascular Diseases Laboratory, Group on the Molecular and Cell Biology of Lipids, Department of Agricultural, Food and Nutritional Science, University of Alberta, Edmonton, Alberta, - - 2014
Non-alcoholic fatty liver disease encompasses a wide spectrum of liver damage including steatosis, non-alcoholic steatohepatitis, fibrosis and cirrhosis. We have previously reported that creatine supplementation prevents hepatic steatosis and lipid peroxidation in rats fed a high-fat diet. In this study, we employed oleate-treated McArdle RH-7777 rat hepatoma cells to investigate ...
Mendez Maxence - - 2014
The ozonolysis of submicron (150 nm) oleic acid (OL) particles has been studied in an aerosol flow tube for a wide range of initial ozone concentrations from 25 ppb to 1,100 ppb. Both reactants were monitored, as well as the four main reaction products (nonanal, azelaic acid, nonanoic acid and ...
Liu Ying Y State Key Laboratory of Material-oriented Chemical Engineering College of Biotechnology and Pharmaceutical Engineering, Nanjing Tech University, No. 30 Puzhu Road, Nanjing, 211816, - - 2014
Ensuring a suitable pH in the culture broth is a major problem in microorganism-assisted industrial fermentation of organic acids. To address this issue, we investigated the physiological changes in Rhizopus oryzae at different extracellular pH levels and attempted to solve the issue of cell shortage under low pH conditions. We ...
Anthony Josephine J Marine Biotechnology Division, ESSO-National Institute of Ocean Technology, Ministry of Earth Sciences, Government of India, Pallikaranai, Chennai, 600 100, India, - - 2014
The present study was aimed at randomly mutating the microalga, Chlorella vulgaris, in order to alter its cellular behaviour towards increased lipid production for efficient biodiesel production from algal biomass. Individual mutants from ultraviolet light (UV-1 (30 s exposure), UV-2 (60 s exposure) and UV-3 (90 s exposure)) and 5'fluorodeoxyuridine ...
Feng Xu X a Navy Medical Research Institute , No. 880 Xiangying Road, Yangpu District, Shanghai 200433 , P.R. - - 2014
Biotransformation of corosolic acid (1) by Cochliobolus lunatus and Streptomyces asparaginoviolaceus afforded four metabolites, which were identified by using (1)H NMR, (13)C NMR, DEPT, HSQC, HMBC and NOESY spectral data. Biotransformation of corosolic acid by C. lunatus R.R. Nelson & Haasis CGMCC 3.4381 produced three metabolites: 2α,3β,21β-trihydroxyurs-12-en-28-oic acid (2), 2α,3β,7β,21β-tetrahydroxy-urs-12-en-28-oic ...
Mottillo Emilio P EP McMaster University, - - 2014
Chronic activation of β3-adrenergic receptors (β3-ARs) expands the catabolic activity of both brown adipose tissue (BAT) and white adipose tissue (WAT) by engaging UCP1-dependent and UCP1 independent processes. The present work examined de novo lipogenesis (DNL) and triglyceride (TG)/glycerol dynamics in classic brown, subcutaneous 'beige', and classic WAT during sustained ...
Roy D D Nanoscience and Technology Division, DMSRDE, GT Road, Kanpur-208013 (India). - - 2014
An easily dispersible multiwalled carbon nanotube (MWCNT) derivative is prepared, and provides a platform for the synthesis of the phenyl butyric acid methyl ester (PCBM) analog. The carbene addition reaction of MWCNTs makes derivatives that are less soluble in organic solvents; by exploiting this differential solubility, PCBM analogs can be ...
Mándity István M IM Institute of Pharmaceutical Chemistry, University of Szeged, Eötvös u. 6, 6720 Szeged - - 2014
A highly efficient continuous-flow technique for the synthesis of peptides was developed. The method allows the application of only 1.5 equivalents of amino acids during coupling, while yielding virtually quantitative conversions. A mesoscale reactor was constructed which permits the use of high temperature and pressure during the synthesis. A complete ...
Ni Lixiao L Key Laboratory of Integrated Regulation and Resource Development on Shallow Lakes, MOE, School of Environment, Hohai University, 210098 Nanjing, China. Electronic address: - - 2014
The unsaturated fatty acid (linoleic acid) sustained-release microspheres were prepared with linoleic acid (LA) using alginate-chitosan microcapsule technology. These LA sustained-release microspheres had a high encapsulation efficiency (up to 62%) tested by high performance liquid chromatography with a photo diode array. The dry microspheres were characterized by a scanning electron ...
Zhang Shuo - - 2014
Lignocellulosic biomass serves as a potential alternative feedstock for production of bacterial nanocellulose (BNC), a high value-added product of bacteria such as Gluconacetobacter xylinus. The tolerance of G. xylinus to lignocellulose-derived inhibitors (formic acid, acetic acid, levulinic acid, furfural and 5-hydroxymethylfurfural) was investigated. While 100 mM of formic acid completely ...
Krenek Kimberley A - - 2014
A detailed characterization of mango pulp polyphenols and other minor phytochemicals was accomplished for the first time in the cultivar 'Keitt', whereby the identification and semi-quantification of five hydroxybenzoic acids, four cinnamic acids, two flavonoids, and six apocarotenoids was accomplished. Among the most abundant compounds were two mono-galloyl glucosides (MGG) ...
Lucken-Ardjomande Häsler Safa - - 2014
Lipid droplets are found in all cell types. Normally present at low levels in the brain, they accumulate in tumours and are associated with neurodegenerative diseases. However, little is known about the mechanisms controlling their homeostasis in the brain. We have found that the longest GRAF1 isoform, GRAF1a, is enriched ...
Jaensch Nina N Department of Biochemistry, University of Geneva Sciences II, CH1-1211, Geneva, - - 2014
Glycosylphosphatidylinositol-anchored proteins (GPI-APs) are a class of lipid-anchored proteins expressed on the cell surface of eukaryotes. The potential interaction of GPI-APs with ordered lipid domains enriched in cholesterol and sphingolipids has been proposed to function in the intracellular transport of these lipid-anchored proteins. Here we examined the biological importance of ...
Gong Tianxun T School of Electrical and Electronic Engineering, Nanyang Technological University, 50 Nanyang Avenue, Singapore 639798, Singapore; Bio-Optical Imaging Group, Singapore Bioimaging Consortium (SBIC), Agency for Science Technology and Research (A*STAR), Helios #01-02, 11 Biopolis Way, Singapore 138667, - - 2014
An ultrasensitive surface enhanced Raman spectroscopy (SERS) based sensing platform was developed to detect the mean sialic acid level on the surface of single cell with sensitivity as low as 2fmol. This platform adopted the use of an interference-free Raman tag, 4-(dihydroxyborophenyl) acetylene (DBA), which selectively binds to sialic acid ...
Zhou Dan D Department of Food Science and Engineering, College of Biological Sciences and Technology, Beijing Key Laboratory of Forest Food Process and Safety, Beijing Forestry University, Beijing 100083, - - 2015
The inhibitory effect and associated mechanisms of salicylic acid (SA) on the browning of fresh-cut Chinese chestnut were investigated. Shelled and sliced chestnuts were immersed in different concentrations of an SA solution, and the browning of the chestnut surface and interior were inhibited. The activities of polyphenol oxidase (PPO) and ...
Mandal Sudhamoy S a Central Horticultural Experiment Station (ICAR) , Aiginia, Bhubaneswar 751019 , - - 2014
Accumulation of phenolic compounds in cell walls of different plant organs leading to increased lignification is an early defence response of plants against biotic stress. The aim of this work was to delineate occurrence of cell wall-bound (CWB) phenolic compounds in Morinda citrifolia leaves. Alkaline hydrolysis of the cell wall ...
O'Doherty Patrick J - - 2014
Abstract Amino acid biosynthesis forms part of an integrated stress response against oxidants in Saccharomyces cerevisiae and higher eukaryotes. Here we show an essential role of the L-lysine biosynthesis pathway in response to the oxidative stress condition induced by the lipid oxidant - linoleic acid hydroperoxide (LoaOOH), by means of ...
Li Juan J Chongqing Key Laboratory of Neurobiology, Chongqing 400016, - - 2014
Major depressive disorder (MDD) is a debilitating mood disorder with various etiopathological hypotheses. However the pathogenesis and diagnosis are still unclear. Peripheral blood mononuclear cells (PBMCs) have been shown to be well-suited to biomarker investigation in major depressive disorder (MDD), as well as to unveil the underlying pathogenesis of MDD. ...
Pelka Karin K Institute of Innate Immunity, University Hospital, University of Bonn, 53127 Bonn, - - 2014
Sensing of nucleic acids by TLRs is crucial in the host defense against viruses and bacteria. Unc-93 homolog B1 (UNC93B1) regulates the trafficking of nucleic acid-sensing TLRs from the endoplasmic reticulum to endolysosomes, where the TLRs encounter their respective ligands and become activated. In this article, we show that a ...
Papadopoulos Giorgos N GN Department of Chemistry, University of Athens, Panepistimiopolis 15771, Athens - - 2014
A fast and efficient visible-light metal-free hydroacylation of dialkyl azodicarboxylates is described. Among a variety of activated ketones, phenyl glyoxylic acid and its ethyl ester were identified as suitable photoorganocatalysts. A range of aliphatic and aromatic aldehydes were employed, thus leading to products in high to excellent yields.
Wang Shuping S State key Laboratory of Coordination Chemistry, School of Chemistry and Chemical Engineering, Nanjing University, PR - - 2014
Dimercaptopropanesulfonic acid (DMPS) has been approved for the treatment of arsenic poisoning through promoting arsenic excretion and modulating arsenic species. To clarify how DMPS regulates the excretion of arsenic species, we investigated the effects of DMPS on the biomethylation of arsenite (As(3+)) in HepG2 cells. In the experiments, we found ...
Abdel-Atty Mona M MM Pharmaceutical Chemistry Department, Faculty of Pharmacy, Misr International University, Cairo 11431, - - 2014
In this study, five series of (E)-6-(4-substituted phenyl)-4-oxohex-5-enoic acids IIb-f (E), (E)-3-(4-(substituted)-phenyl)acrylic acids IIIa-g (E), 4-(4-(substituted)phenylamino)-4-oxobutanoic acids VIa,b,e, 5-(4-(substituted)phenylamino)-5-oxopentanoic acids VIIa,f and 2-[(4-(substituted)phenyl) carbamoyl]benzoic acids VIIIa,e were designed and synthesized. Selected compounds were screened in vitro for their cytotoxic effect on 60 human NCI tumor cell lines. Compound IIf (E) ...
Ozaki Yuya - - 2014
Proteorhodopsin (PR) is a light-driven proton pump found in marine bacteria. More than a thousand PRs are classified into blue-absorbing (λmax ~490 nm) and green-absorbing (λmax ~525 nm) PR. The color determinant is known to be at position 105, where blue-absorbing and green-absorbing PRs possess Gln and Leu, respectively. This ...
Antal Otilia - - 2014
Based on previous observations a potential resort in the therapy of the particularly radioresistant glioma would be its treatment with unsaturated fatty acids (UFAs) combined with irradiation. We evaluated the effect of different UFAs (arachidonic acid (AA), docosahexaenoic acid (DHA), gamma-linolenic acid (GLA), eicosapentaenoic acid (EPA) and oleic acid (OA)) ...
Osińska-Jaroszuk Monika M Department of Biochemistry, Maria Curie-Sklodowska University, Akademicka Street 19, 20-033, Lublin, Poland, - - 2014
The secretion of exopolysaccharides and oxalic acid in cultures of a white rot Ganoderma applanatum strain and a brown rot Tyromyces palustris strain were tested in terms of culture time, pH range, and temperature. The high yield of exopolysaccharides (EPS) required a moderate temperature of 28 °C for G. applanatum and ...
Holl Eda K EK Durham, N.C. From the Departments of Surgery and Pathology, Duke University Medical - - 2014
Pathologic cutaneous scarring affects over 40 million people worldwide and costs billions of dollars annually. Understanding mechanisms of fibroblast activation and granulation tissue contraction is the first step toward preventing pathologic scarring. The authors hypothesize that nucleic acids increase fibroblast activation and cause granulation tissue contraction and that sequestration of ...
Shafqatullah - Institute of Chemical Sciences, University of Peshawar, Peshawar, Pakistan / Pakistan Council of Scientific and Industrial Research Peshawar, Peshawar, - - 2014
A simple and rapid chromatographic method has been developed for the simultaneous determination of five phenolic acids including Gallic acid, Chloroganic acid, Syringic acid, Benzoic acid and Vanillic acid by HPLC with UV-VIS detector. These Phenolic acids were separated by analytical column Intersil ODS-3 C18, a gradient elution system of ...
Mustufa Muhammad Ayaz MA Bilkent University, BilGen Genetics and Biotechnology Research Center, Deptt of Molecular Biology and Genetics, Ankara, Turkey / BIPS and Department of Biochemistry, Baqai Medical University, Karachi, - - 2014
Oleanolic acid (3β-hydroxy-olean-12-en-28-oic acid; OA-01), a pentacyclic triterpene, exhibit a wide range of pharmacological and biological activities. We have isolated oleanolic acid from methanolic extract of Periploca aphylla, collected from surroundings of Karachi in the month of February. Furthermore, four known and two new C-28 amino acid conjugates of oleanolic ...
Yu Q Q Department of Chemistry and Biochemistry, Concordia University, Montreal, Canada. - - 2014
LiYF4:Tm(3+)/Yb(3+) upconverting nanoparticles (UCNPs) were functionalized with the second generation photosensitizer 5,10,15,20-tetra(m-hydroxyphenyl)chlorin (m-THPC, Temoporfin, Foscan®). m-THPC was modified using 4-(bromomethyl)benzoic acid, which induced a bathochromic shift of the m-THPC blue absorption peak. The nanoconstruct causes up to 70% cell death under 980 nm irradiation.
Ma Jun - - 2014
Eight solutions containing phosphoric acid with concentration ranging from 2 mol L-1 to neat acid have been studied by picosecond pulse radiolysis. The absorbance of the secondary radical H2PO4• formed within 7 ps of the electron pulse is observed using pulse-probe method in the visible. Kinetic analysis shows that the ...
Xu Yun - - 2014
MON 87460 (D1) maize contains a gene that expresses the cold shock protein B (CSPB) from Bacillus subtilis to confer a yield advantage when yield is limited by water availability. This study evaluated the composition of grain from the D1-containing combined-trait maize hybrids: D1 × NK603, D1 × MON 89034 ...
Bera Anupam A Academy of Scientific and Innovative Research, Gijubhai Badheka Marg, Bhavnagar-364002 - - 2014
Production of polyhydroxyalkanoates (PHAs) from Jatropha biodiesel residues, namely crude glycerol and oil cake hydrolysate, has been reported previously. Halomonas hydrothermalis (MTCC accession no. 5445; NCBI Genbank accession no. GU938192), a wild marine strain, was used in the bio-synthesis. The present study was initiated to vary the properties of the ...
Souza Joanne M M JM Laboratório de Investigação Sistemática em Biotecnologia e Biodiversidade Molecular/LabISisBio, Instituto de Ciências Exatas e Naturais, Universidade Federal do Pará, Belém, PA, - - 2014
In this study, a protocol to induce high amount of friable callus of Boerhaavia paniculata RICH and a lipidomics technique were applied to investigate the profile of lipids to relate to those present in the roots of this plant that presented anti-inflammatory activity in the crude hexane extract. The callus ...
Ramalho Suelem D SD Department of Chemistry, Federal University of São Carlos, 13565-905 São Carlos, SP, Brazil, (phone: +55-16-33518061; fax: - - 2014
Cathepsins L (catL) and B play an important role in tumor progression and have been considered promising therapeutic targets in the development of novel anticancer agents. Using a bioactivity-guided fractionation, a series of triterpenoids was identified as a new class of competitive inhibitors towards cathepsin L with affinity values in ...
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