Search Results
Results 301 - 350 of 2596
< 2 3 4 5 6 7 8 9 10 11 12 >
Kanitkar Akanksha A Audubon Sugar Institute, Louisiana State University Agricultural Center, St. Gabriel, LA, USA Department of Biological and Agricultural Engineering, Louisiana State University and Agricultural Center, Baton Rouge, LA, - - 2014
In this study, a novel class of polyesters of glycerol, aconitic acid, and cinnamic acid were synthesized along with their hydroxyapatite (HA) composites, and studied for their potential application in bone defect repair. An osteogenic study was conducted with human adipose derived mesenchymal stem cells (hASCs) to determine the osteoinductive ...
McDougle Daniel R DR Department of Comparative Biosciences (D.R.M., A.D.), Department of Biochemistry (A.K., D.D.M., A.D.), and Medical Scholars Program (D.R.M.), Beckman Institute for Advanced Science and Technology, and Department of Bioengineering (A.D.), University of Illinois Urbana-Champaign, Urbana, - - 2014
The endocannabinoids, anandamide (AEA) and 2-arachidonoylglycerol (2-AG), are arachidonic acid (AA) derivatives that are known to regulate human cardiovascular functions. CYP2J2 is the primary cytochrome P450 in the human heart and is most well known for the metabolism of AA to the biologically active epoxyeicosatrienoic acids. In this study, we ...
Yu Huan H Department of Obstetrics and Gynecology, Peking University Third Hospital, Beijing 100191, - - 2014
Preeclampsia (PE) is associated with abnormal fatty acid beta-oxidation (FAO), especially metabolic disorders of long-chain fatty acid oxidation. The role of FAO dysfunction in inadequate invasion is unclear. The aim of this study was to explore the influence of various lengths fatty acids oxidation on invasiveness of trophoblasts. Primary human ...
Yarar Saniye S Deva Holding, Halkalı Merkez Mahallesi, Küçükçekmece , Istanbul , - - 2014
The construction of an L-lysine biosensor on ammonium-selective poly(vinylchloride) (PVC) membrane electrode is described in this study. The construction procedure occurs in two stages: (I) the preparation of ammonium-selective poly(vinylchloride) (PVC) membrane electrode and (II) the chemical immobilization of lysine oxidase on this ammonium-selective electrode by using glutaraldehyde. The ammonium ...
Senaweera Sameera - - 2014
This work describes the facile and selective mono-perfluoro and polyfluoroarylation of Meldrum's acid to generate a versatile synthon for highly fluorinated alpha-phenyl acetic acid derivatives which provide straightforward access to fluorinated building blocks. The reaction takes place quickly and most products were isolated without the need for chromatography. Importantly, this ...
Theofilopoulos Spyridon - - 2014
Cholestenoic acids are formed as intermediates in metabolism of cholesterol to bile acids, and the biosynthetic enzymes that generate cholestenoic acids are expressed in the mammalian CNS. Here, we evaluated the cholestenoic acid profile of mammalian cerebrospinal fluid (CSF) and determined that specific cholestenoic acids activate the liver X receptors ...
Natarajan Niranjana N Johns Hopkins University School of - - 2014
Recent studies have highlighted a myriad of ways in which the activity and composition of the gut microbiota can affect the host organism. A primary way in which the gut microbiota affect host physiology is by the production of metabolites, such as short chain fatty acids (SCFAs), which are subsequently ...
Sakihama Yuri Y Department of Chemical Science and Engineering, Graduate School of Engineering, Kobe University, 1-1 Rokkodai, Nada, Kobe 657-8501, - - 2014
The hydrolysis of lignocellulosic biomass liberates sugars, primarily glucose and xylose, which are subsequently converted to ethanol by microbial fermentation. The rapid and efficient fermentation of xylose by recombinant Saccharomyces cerevisiae strains is limited by weak acids generated during biomass pretreatment processes. In particular, acetic acid negatively affects cell growth, ...
Wang RuoWen R Molecular Sciences and Biomedicine Laboratory, State Key Laboratory for Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering and College of Biology, Collaborative Innovation Center for Chemistry and Molecular Medicine, Hunan University, Changsha 410082, - - 2014
An artificial nucleic acid analogue capable of self-assembly into duplex merely through hydrophobic interactions is presented. The replacement of Watson-Crick hydrogen bonding with strictly hydrophobic interactions has the potential to confer new properties and facilitate the construction of complex DNA nanodevices. To study how the hydrophobic effect works during the ...
Rajesh P P PP PK Sinha Centre for Bioenergy, Indian Institute of Technology, Kharagpur - 721302, - - 2014
Methanogens compete with anodophiles for substrate and thus reduce the power generation and coulombic efficiency (CE) of the microbial fuel cell (MFC). Performance of a baked clayware membrane MFC inoculated with mixed anaerobic sludge pretreated with lauric acid was investigated in order to enhance power recovery by controlling methanogenesis. In ...
Nejadsadeghi Leila L Department of Agronomy and Plant Breeding, University College of Agriculture and Natural Resources, University of Tehran, Karaj, - - 2014
Plant cells often increase cold tolerance by reprogramming their genes expression which results in adjusted metabolic alternations, a process enhanced under cold acclimation. In present study, we assessed the changes of membrane fatty acid compositions along with physio-biochemical indices like H2O2 and malondialdehyde (MDA) contents and lipoxygenase (LOX) activity during ...
Kamisaka Yasushi Y Bioproduction Research Institute, National Institute of Advanced Industrial Science and Technology (AIST), Tsukuba, Ibaraki, 305-8566, Japan, - - 2014
Palmitoleic acid (POA) has recently gained attention for its health benefits and as a potential resource for industrial feedstock. This study focused on the use of Saccharomyces cerevisiae, which has a high POA content but low lipid content, for POA production. We created an oleaginous S. cerevisiae as a dga1 ...
Tone Junichi J a Laboratory of Molecular Physiology and Genetics, Faculty of Agriculture , Ehime University , Matsuyama , - - 2014
Active transport systems for various amino acids operate in the vacuolar membrane of Saccharomyces cerevisiae. The gene families for vacuolar amino acid transporters were identified by reverse genetics experiments. In the AVT transporter family, Avt1p works for active uptake of amino acid into vacuole, and Avt3p, Avt4p, and Avt6p for ...
El Alaoui Meddy - - 2014
To date, several sensitive methods, based on radiolabeled elements or sterically hindered fluorochrome groups, are usually employed to screen phospholipase A (PLA) activities. Aiming at developing a convenient, specific, sensitive and continuous new ultraviolet (UV) spectrophotometric assay for PLA, we have synthesized a specific glycerophosphatidylcholine (PC) esterified on the position ...
Kang Chuanqing C State Key Laboratory of Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, 5625 Renmin Street, Changchun 130022, China. kangcq@ciac.ac.cn - - 2014
New simple hydrogelators containing the structural features of cyclic amino acids were investigated for water gelation through H-bonds from carboxylic acids and amino groups, showing for the first time the use of a single amino acid as a hydrogelator. The hydrogels were used for the synthesis of Pt and Ir ...
Xu Wei-Dong WD Department of Orthopedics, Changhai Hospital Affiliated to the Second Military Medical University, Shanghai, - - 2014
The present study first utilized a standardized shotgun proteomic analysis method to determine differences in protein expression of fibroblasts in the ligament between AS patients and healthy controls. Proteins extracted from primarily cultured FLLs from 35 AS patients and 10 normal subjects were analyzed by automated 2D-Nano-LC-ESI-MS/MS. Differentially expressed proteins ...
Huang Hui-Ying HY Department of Nutrition, China Medical University, Taichung 404, Taiwan, - - 2014
Some lactic acid bacteria (LAB) possess probiotic properties beneficial to human health. However, both gastric acid and bile salt have adverse influences on the survival and viability of ingested probiotics. This research investigated the changes in potential probiotic properties of LAB strains after treatment with simulated gastrointestinal (GI) conditions. Three ...
Abdel-Rahman Mohamed Ali MA Laboratory of Microbial Technology, Division of Systems Bioengineering, Department of Bioscience and Biotechnology, Faculty of Agriculture, Graduate School, Kyushu University, 6-10-1 Hakozaki, Higashi-ku, Fukuoka 812-8581, Japan; Botany and Microbiology Department, Faculty of Science (Boys), Al-Azhar University, Nasr City PN:11884, Cairo, Egypt. Electronic address: - - 2014
There has been tremendous growth in the production of optically pure l-lactic acid from lignocellulose-derived sugars. In this study, Enterococcus mundtii QU 25 was used to ferment a glucose/xylose mixture to l-lactic acid. Maintenance of the xylose concentration at greater than 10 g/L achieved homo-lactic acid fermentation and reduced the formation ...
Caputo Mariella M Department of Pharmacy, University of Salerno, Fisciano, Salerno, - - 2014
Stearoyl-CoA desaturase 1 (SCD1) is the rate limiting enzyme in unsaturated fatty acid biosynthesis. This enzyme has an important role in the regulation of hepatic lipogenesis and lipid oxidation, and alterations in these pathways may lead to several diseases. We examined, in HepG2 cell cultures, the mechanism of SCD1 regulation ...
Park Gwon Woo GW Department of Chemical and Bimolecular Engineering, KAIST, Yuseong-gu, Daejeon 305-701, - - 2014
Volatile fatty acids (VFAs) derived from waste organics were used as low cost carbon source, for high bioreactor productivity and titer, and multi-stage continuous high cell density culture (MSC-HCDC) process was employed for economic assessment of microbial lipids for biodiesel production. The simulation study used a lipid yield of 0.3g/g-VFAs, ...
Ghaddar Kassem K Molecular Physiology of the Cell, Université Libre de Bruxelles, IBMM, 6041 Gosselies, - - 2014
Many plasma membrane transporters are downregulated by ubiquitylation, endocytosis, and delivery to the lysosome, in response to various stimuli. We report here that two amino acid transporters of Saccharomyces cerevisiae, the general amino-acid permease (Gap1) and the arginine-specific permease (Can1), undergo ubiquitin-dependent downregulation in response to their substrates, and that ...
Masi Marco - - 2014
Two new phytotoxic sesquiterpenoid acids, named pyrenophoric acids B and C, were isolated together with the related pyrenophoric and abscisic acids from solid Bromus tectorum (cheatgrass) seed culture of the seed pathogen Pyrenophora semeniperda. This fungus has been proposed as a mycoherbicide for biocontrol of cheatgrass (Bromus tectorum), a Eurasian ...
Zhang Xiu-Feng XF College of Chemical Engineering, Hebei United University, Tangshan, Hebei 063009, China. Electronic address: - - 2014
Transferrin has shown potential in the delivery of anticancer drugs into primarily proliferating cancer cells that over-express transferrin receptors. Fulvic acid has a wide range of biological and pharmacological activities which caused widespread concerns, the interaction of fulvic acid with human serum transferrin (Tf) has great significance for gaining a ...
Jadoon Ayesha A Diabetes and Nutritional Sciences Division, School of Medicine, United - - 2014
Pre-eclampsia is characterized by placental hypoxia and dyslipidemia. Arachidonic and docosahexanoic acids are essential maternal nutrients for fetal development. They are transported via placental trophoblast cells by membrane and cytosolic fatty acid binding proteins. Others report the expressions of these proteins which are increased in hypoxic trophoblasts. Using bioinformatics, BeWo ...
Liu Wei W School of Chemistry and Materials Science, Ludong University, Yantai 264025, PR - - 2014
Biodiesel production has become an intense research area because of rapidly depleting energy reserves and increasing petroleum prices together with environmental concerns. This paper focused on the optimization of the catalytic performance in the esterification reaction of oleic acid for biodiesel production over the bifunctional catalyst organotriphosphonic acid-functionalized ferric alginate ...
Nikolov Nikolai G NG Division of Toxicology and Risk Assessment, National Food Institute, Technical University of Denmark, Mørkhøj Bygade 26, 2860 Søborg, Denmark. Electronic address: - - 2014
Ionization is a key factor in hERG K(+) channel blocking, and acids and zwitterions are known to be less probable hERG blockers than bases and neutral compounds. However, a considerable number of acidic compounds block hERG, and the physico-chemical attributes which discriminate acidic blockers from acidic non-blockers have not been ...
Zhang Hongcheng H Department of Food Science, University of Manitoba, Winnipeg R3T 2N2, Canada; Bee Research Institute, Chinese Academy of Agricultural Sciences, Beijing 100093, - - 2015
Advanced breeding lines made from the cross between the black and white rice as parents were collected to evaluate phenolic levels and antioxidant properties. No free phenolic acid was found in the soluble fraction, while p-coumaric acid, ferulic acid, isoferulic acid and vanillic acid were identified in insoluble bound fractions. ...
Hronská Helena H Department of Biochemical Technology, Faculty of Chemical and Food Technology, Slovak University of Technology, Radlinského 9, 812 37, Bratislava, Slovakia, - - 2014
The bacterial strains of the genus Nocardia were used for the bioconversion of fumaric acid to L-malic acid. The ability of the bacterial strain Nocardia sp. CCM 4837/A to produce L-malic acid from fumaric acid was investigated under various conditions. The optimal temperature for the bioconversion was approximately 37 °C, and ...
Otto Alexander A Department of Bioorganic Chemistry, Leibniz Institute of Plant Biochemistry, Weinberg 3, D-06120 Halle/Saale, - - 2014
Five sesquiterpene carboxylic acids (1-5) and one nor-sesquiterpene carboxylic acid (6) of the very rare ventricosane type, named penarines A-F, were isolated from fruiting bodies of the basidiomycete Hygrophorus penarius (Hygrophoraceae). This is the first report of (nor)-sesquiterpenes isolated from basidiocarps of the family Hygrophoraceae. Their structures were elucidated on ...
Thulasiraman Padmamalini - - 2014
A major obstacle in the use of retinoid therapy in cancer is the resistance to this agent in tumors. Retinoic acid facilitates the growth of mammary carcinoma cells which express high levels of fatty acid-binding protein 5 (FABP5). This protein delivers retinoic acid to peroxisome proliferator-activated receptor beta/delta (PPARbeta/delta) that ...
Bryant Sarah L SL Division of Cancer Biology, Institute of Cancer Research, 237 Fulham Road, London SW3 6JB, United - - 2014
The mammalian urogenital sinus (UGS) develops in a sex specific manner, giving rise to the prostate in the male and the sinus vagina in the embryonic female. Androgens, produced by the embryonic testis, have been shown to be crucial to this process. In this study we show that retinoic acid ...
Xu Wenlong W Key Laboratory of Colloid and Interface Chemistry, Shandong University , Ministry of Education, Jinan 250100, P. R. - - 2014
Fatty acid bilayers are usually formed due to the hydrogen bonds between the protonated carboxyl (-COOH) and the deprotonated carboxylate (-COO(-)). Therefore, the formation of the bilayers must be at the pH around the pKa of the fatty acid, which is a narrow pH range (mostly about 7-9). Fatty acid ...
Hwang Buyng Su BS Department of Marine Biotechnology, Kunsan National University , Jeonbuk, 573-701, South - - 2014
Acuminolide A (1), along with pectenotoxin II (PTX-2), dinophysistoxin I (DTX-1), okadaic acid (OA), and 7-epi-PTX-2 seco acid, was isolated from a large-scale cultivation of the dinoflagellate Dinophysis acuminata. The new 33-membered macrolide 1 was characterized by detailed analysis of 2D NMR and MS data. Its relative stereochemistry was elucidated ...
Seo Min-Ju MJ Department of Bioscience and Biotechnology, Konkuk University, 1 Hwayang-dong, Gwangjin-Gu, Seoul, 143-701, Republic of - - 2014
The optimal conditions for the production of 5,8-dihydroxy-9(Z)-octadecenoic acid (5,8-diHOME) from oleic acid by whole recombinant Escherichia coli cells expressing diol synthase from Aspergillus nidulans were 40 °C, pH 7.5, 10 % (v/v) dimethyl sulfoxide, 35 g cells l(-1), and 12 g oleic acid l(-1) at 250 rpm in a 250 ml baffled flask. Under these ...
Tarlani Aliakbar A Chemistry & Chemical Engineering Research Center of Iran (CCERCI), Pazhouhesh Blvd., 17th Km. of Tehran- Karaj Highway, Tehran, Iran. Electronic address: - - 2014
In a new approach, shape controlled synthesis of zinc oxide nanostructures were carried out using a solvothermal route assisted amino acids such as l-Lysine (lysine), l-Cysteine (cysteine) and l-Arginine (arginine) as bifunctional species with (or without) urea or oxalic acid as additives which affect the pH of the reaction. Rod, ...
Koshio Aya A Graduate School of Science and Technology, Niigata University, Ikarashi, Nishi-ku, Niigata, Niigata 950-2181, - - 2014
The short-day plant pharbitis (also called Japanese morning glory), Ipomoea nil (formerly Pharbitis nil), was induced to flower by poor-nutrition stress. This stress-induced flowering was inhibited by aminooxyacetic acid (AOA), which is a known inhibitor of phenylalanine ammonia-lyase (PAL) and the synthesis of indole-3-acetic acid (IAA) and 1-aminocycropropane-1-carboxylic acid (ACC) ...
Maeda Dean Yoshimasa - - 2014
The G protein-coupled chemokine receptors CXCR1 and CXCR2 play key roles in inflammatory diseases and carcinogenesis. In inflammation, they activate and recruit polymorphonuclear cells (PMNs) through binding of the chemokines CXCL1 (CXCR1) and CXCL8 (CXCR1 and CXCR2). Structure-activity studies that examined the effect of a novel series of S-substituted 6-mercapto-N-phenyl-nicotinamides ...
Zhang Quanxuan - - 2014
A new simple and practical protocol for scalable synthesis of a novel library of propargylated and PEGylated alpha-hydroxy acids towards the preparation of 'clickable' polylactides was described. The overall synthesis starting from readily available propargyl alcohol, bromoacetaldehyde diethyl acetal and OEGs or PEGs was developed as a convenient procedure with ...
McCune Jade A JA QUILL, The Queen's University of Belfast, Belfast, BT9 5AG, UK. - - 2014
Gutmann Acceptor Number (AN) values have been determined for Brønsted acid-ionic liquid mixtures, over a wide compositional range. Four systems of general formula [C2mim][A]-HA (A(-) = bistriflamide, [NTf2](-); triflate, [OTf](-); mesylate, [OMs](-); or acetate, [OAc](-), [C2mim](+) = 1-ethyl-3-methylimidazolium cation) were studied. A library of Brønsted acidic systems of varying acidity ...
Popeijus Herman E HE Department of Human Biology, NUTRIM School for Nutrition, Toxicology and Metabolism, Maastricht University, PO Box 616, 6200 MD, Maastricht, The - - 2014
Fatty acids regulate PPARα activity, however, most studies evaluated the binding ability of fatty acids to PPARα, which does not necessarily results in PPARα transactivation. We therefore examined dose-response relationships between fatty acids and PPARα transactivation in HepG2 cells. Secretion of apoA-I protein as-well-as CPT1, ACO, and PPARα mRNA expression, ...
Iqbal Zeeshan Z Institute of Molecular Sciences & Bioinformatics, Lahore, - - 2014
Several models that predict where post-translational modifications are likely to occur and formulate the corresponding association rules are available to analyze the functional potential of a protein sequence, but an algorithm incorporating the functional groups of the involved amino acids in the sequence analyses process is not yet available. In ...
Morales-delaRosa Silvia S Sustainable Energy and Chemistry Group (EQS), Instituto de Catálisis y Petroleoquímica, CSIC, Marie Curie, 2 Cantoblanco, 28049 Madrid (Spain) - - 2014
This work describes a relatively simple methodology for efficiently deconstructing cellulose into monomeric glucose, which is more easily transformed into a variety of platform molecules for the production of chemicals and fuels. The approach undertaken herein first involves the dissolution of cellulose in an ionic liquid (IL), followed by a ...
Wang Zhongqiang Z William G. Lowrie Department of Chemical & Biomolecular Engineering, The Ohio State University, 140 W. 19th Ave, Columbus, OH43210, - - 2014
Propionic acid is an important chemical with wide applications and its production via fermentation is of great interest. However, economic production of bio-based propionic acid requires high product titer, yield, and productivity in the fermentation. A highly efficient and stable high cell density (HCD) fermentation process with cell recycle by ...
Yuan Lin L Department of Human Nutritional Sciences, University of Manitoba, Winnipeg, Manitoba, R3T 2N2, - - 2014
Alkali/acid-pretreated canola meal and mustard bran were subjected to endo-1,4-β-xylanase (T. longibrachiatum) hydrolysis for oligosaccharide production. Pretreatments significantly (α = 0.05) increased the relative content of pentose sugars, especially in alkali-pretreated canola meal (∼44 %) and mustard bran (∼72 %). The amounts of pentosan (g/100 g) in acid- and alkali-pretreated canola meal were 7.50 and ...
Duca Frank A FA Toronto General Research Institute and Department of Medicine, UHN, Toronto, Canada, M5G - - 2014
The ability to properly sense both ingested and circulating nutrients is crucial for the maintenance of metabolic homeostasis. As such, both the gastrointestinal tract and the hypothalamus have demonstrated the capacity to sense and effectively respond to nutrients, such as fatty acids, to control food intake and glucose production to ...
Suk Seo Min M Department of Pharmacology, School of Medicine, Institute of Health Sciences, Gyeongsang National University, Jinju 660-751, - - 2014
Magnolia officinalis (MO) is a traditional Chinese herbal medicine that has been used in clinical practice to treat liver disease. The aim of this study is to examine the effects of MO on the development of nonalcoholic fatty liver in hepatocytes. Human hepatoma-derived HepG2 cells and mouse normal FL83B hepatocytes ...
Kildegaard Kanchana R KR The Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark, Kogle Allé 6, DK-2970 Hørsholm, - - 2014
Biologically produced 3-hydroxypropionic acid (3HP) is a potential source for sustainable acrylates and can also find direct use as monomer in the production of biodegradable polymers. For industrial-scale production there is a need for robust cell factories tolerant to high concentration of 3HP, preferably at low pH. Through adaptive laboratory ...
Chantranupong Lynne L Department of Biology, Whitehead Institute for Biomedical Research and Massachusetts Institute of Technology, 9 Cambridge Center, Cambridge, MA 02142, USA; Department of Biology, Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Koch Institute for Integrative Cancer Research, 77 Massachusetts Avenue, Cambridge, MA 02139, USA; Broad Institute of Harvard and Massachusetts Institute of Technology, 7 Cambridge Center, Cambridge MA 02142, - - 2014
The mechanistic target of rapamycin complex 1 (mTORC1) kinase is a major regulator of cell growth that responds to numerous environmental cues. A key input is amino acids, which act through the heterodimeric Rag GTPases (RagA or RagB bound to RagC or RagD) in order to promote the translocation of ...
Bensaad Karim K CRUK Hypoxia and Angiogenesis Group, The Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Headington, Oxford OX3 9DS, UK. Electronic address: - - 2014
An in vivo model of antiangiogenic therapy allowed us to identify genes upregulated by bevacizumab treatment, including Fatty Acid Binding Protein 3 (FABP3) and FABP7, both of which are involved in fatty acid uptake. In vitro, both were induced by hypoxia in a hypoxia-inducible factor-1α (HIF-1α)-dependent manner. There was a significant lipid ...
Barros Stephanie A SA Department of Chemistry, University of Pennsylvania, 231 South 34th Street, Philadelphia, PA 19104 - - 2014
The modulation of nucleic acids by small molecules is an essential process across the kingdoms of life. Targeting nucleic acids with small molecules represents a significant challenge at the forefront of chemical biology. Nucleic acid junctions are ubiquitous structural motifs in nature and in designed materials. Herein, we describe a ...
< 2 3 4 5 6 7 8 9 10 11 12 >