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Nagarajan V V Department of Colloids and Materials Chemistry, CSIR-Institute of Minerals and Materials Technology, P. O. R.R.L, Bhubaneswar, India. - - 2014
Tuning the pKa in acid sensitive rhodamine spirolactam derivatives as a function of the solvent medium resulted in the selective detection of picric acid from its lower nitro phenolic analogues and a few other carboxylic acids.
Choi June J Department of Otorhinolaryngology-Head and Neck Surgery, Korea National University Hospital, Seoul National University College of Medicine, Seoul, Republic of - - 2014
Cisplatin is a widely used anticancer chemotherapeutic agent. However, it is notorious for its ototoxicity and nephrotoxicity due to induction of reactive oxygen species (ROS). Caffeic acid is a naturally occurring polyphenol present in honey that is known to reduce the generation of oxygen-derived free radicals. The objective of the ...
Borodina Irina I The Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark, Kogle allé 6, DK-2970 Hørsholm, Denmark. Electronic address: - - 2014
Microbial fermentation of renewable feedstocks into plastic monomers can decrease our fossil dependence and reduce global CO2 emissions. 3-Hydroxypropionic acid (3HP) is a potential chemical building block for sustainable production of superabsorbent polymers and acrylic plastics. With the objective of developing Saccharomyces cerevisiae as an efficient cell factory for high-level ...
Ahmar Siawash S Department of Chemistry, University of Waterloo , Waterloo, Ontario N2L 3G1, - - 2014
The conjugate alkynylation of alkylidene Meldrum's acids with alkynylalanes and alkynyl Grignards allows for the formation of propargylic all-carbon quaternary stereocenters in high yields. Ag2CO3-catalyzed intramolecular cyclization of propargylic Meldrum's acid derivatives offers a two-step entry into complex γ-alkylidene butyrolactones containing an all-carbon quaternary center at the C-4 position.
Csatayova Kristina - - 2014
A range of enantiopure polyhydroxylated piperidines, including (2R,3S,4R)-dihydroxypipecolic acid, (-)-3-epi-fagomine, (2S,3S,4R)-dihydroxyhomopipecolic acid, (2S,3R,4R)-dihydroxyhomopipecolic acid and two trihydroxy substituted homopipecolic acids, have been prepared using the diastereoselective olefinic oxidations of a range of enantiopure tetrahydropyridines as the key step. The requisite substrates were readily prepared from tert-butyl sorbate using our diastereoselective ...
Kwon Tae-Woo TW Graduated School of EEWS and KAIST Institute NanoCentury, Korea Advanced Institute of Science and Technology (KAIST), Daejeon, 305-701, - - 2014
Covalent or Noncovalent? Systematic investigation of polymeric binders incorporating Meldrum's acid reveals most critical binder properties for silicon -anodes in lithium ion batteries, that is self-healing effect facilitated by a series of noncovalent interactions.
Zhang An A William G. Lowrie Department of Chemical and Biomolecular Engineering, The Ohio State University, 140 West 19th Avenue, Columbus, OH 43210, - - 2014
The effects of CO2 on propionic acid production and cell growth in glycerol or glucose fermentation were investigated in this study. In glycerol fermentation, the volumetric productivity of propionic acid with CO2 supplementation reached 2.94g/L/day, compared to 1.56g/L/day without CO2. The cell growth using glycerol was also significantly enhanced with ...
Zhang Qi Q State Key Laboratory of Medicinal Chemical Biology, Research Centre for Analytical Sciences, Nankai University, Tianjin 300071, P.R. China; Collaborative Innovation Center of Chemical Science and Engineering (Tianjin), Tianjin 300071, P.R. - - 2014
A simple mix-and-detect photoluminescence method was developed for the turn-on detection of acidic amino acids. To achieve this, graphene quantum dots (GQDs), which emit both down-conversion and up-conversion photoluminescence were prepared by solvothermal synthesis. The carboxylic acid-rich surface not only increases the water solubility of the prepared GQDs, but also ...
Bai Aiping A Department of Biochemistry & Molecular Biology, Medical University of South Carolina, 173 Ashley Ave., Charleston, SC 29425, USA; Lipidomics Facility, Medical University of South Carolina, 173 Ashley Ave., Charleston, SC 29425, - - 2014
Acid ceramidase (ACDase) is being recognized as a therapeutic target for cancer. B13 represents a moderate inhibitor of ACDase. The present study concentrates on the lysosomal targeting of B13 via its N,N-dimethylglycine (DMG) esters (DMG-B13 prodrugs). Novel analogs, the isomeric mono-DMG-B13, LCL522 (3-O-DMG-B13·HCl) and LCL596 (1-O-DMG-B13·HCl) and di-DMG-B13, LCL521 (1,3-O, ...
Legako J F JF Department of Nutrition, Dietetics, & Food Sciences, Utah State University, Logan, UT 84322, United States. Electronic address: - - 2014
The effects of USDA beef quality grade (QG; Prime, Low Choice, and Standard; n=8) and cooking (RC) on fatty acid (FA) concentrations (mg/g dry matter) and percentages of neutral and polar lipid fractions (NL and PL, respectively) from strip steaks were explored. An increase in QG led to an accumulation ...
Li Tan T Department of Pathogen Biology and Immunology, Logistics University of the Chinese People׳s Armed Police Force, Tianjin 300309, China; Tianjin Key Laboratory of Cardiovascular Remodeling and Target Organ Injury, Institute of Cardiovascular Disease and Heart Center, The Affiliated Hospital of Logistics University of the Chinese People׳s Armed Police Force, Tianjin 300162, China. Electronic address: - - 2014
Identification of immunosuppressants from natural sources has a proven track record in immune mediated disorders. Pseudolaric acid B is a diterpenoid isolated from the roots of Pseudolarix amabilis, possessing potent immunomodulatory effect. However, the cytotoxicity limits its future clinical application. The purpose of this study was to investigate the immunosuppressive ...
Deborah M M Department of Chemistry, NMSSVN College, Madurai 625 019, Tamil Nadu, - - 2014
Single-walled carbon nanotubes (SWCNTs) have a great potential in a wide range of applications, but faces limitation in terms of dispersion feasibility. The functionalization process of SWCNTs with the amino acid, glycine involves oxidation reaction using a mild aqueous acid mixture of HNO3 and H2SO4 (1:3), via ultrasonication technique and ...
Oninla Vincent O VO LIMES Institute, Membrane Biology and Lipid Biochemistry Unit, Kekulé-Institut für Organische Chemie und Biochemie, Universität Bonn, D-53121 Bonn, Germany Department of Chemistry, University of Ibadan, Ibadan, - - 2014
During endocytosis, membrane components move to intraluminal vesicles of the endolysosomal compartment for digestion. At the late endosomes, cholesterol is sorted out mainly by two sterol-binding proteins, Niemann-Pick protein type C (NPC)1 and NPC2. To study the NPC2-mediated intervesicular cholesterol transfer, we developed a liposomal assay system. (Abdul-Hammed, M., B. ...
Fei Qiang Q Department of Chemical and Bimolecular Engineering, KAIST, Daejeon, 305-701, Korea, - - 2014
Volatile fatty acids (VFAs) that can be derived from food wastes were used for microbial lipid production by Chlorella protothecoides in heterotrophic cultures. The usage of VFAs as carbon sources for lipid accumulation was investigated in batch cultures. Culture medium, culture temperature, and nitrogen sources were explored for lipid production ...
Guo Zhongpeng Z Department of Chemical and Biological Engineering, Industrial Biotechnology, Chalmers University of Technology, SE-412 96, Gothenburg, - - 2014
Weak acids are present in lignocellulosic hydrolysate as potential inhibitors that can hamper the use of this renewable resource for fuel and chemical production. To study the effects of weak acids on yeast growth, physiological investigations were carried out in batch cultures using glucose as carbon source in the presence ...
Ao Yu-Fei YF Beijing National Laboratory for Molecular Sciences, CAS Key Laboratory of Molecular Recognition and Function, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190 (P.R. - - 2014
Catalyzed by Rhodococcus erythropolis AJ270, a nitrile hydratase-amidase containing microbial whole-cell catalyst under mild conditions, enantioselective desymmetrizations of meso-cyclopentane-1,3-dicarbonitriles and cyclopentane-1,3-dicarboxamides were studied. Although the nitrile hydratase was found to exhibit high enzymatic activity, but low 1R enantioselectivity toward dinitriles, a number of 2,2-unsymmetrically substituted meso-cyclopentane-1,3-dicarboxamide substrates were converted by ...
Xing Su-Fang SF Shandong Key Laboratory of Water Pollution Control and Resource Reuse, School of Environmental Science and Engineering, Shandong University, Jinan, 250100, - - 2014
Bacterial biofilms are structured communities of cells enclosed in a self-produced hydrated polymeric matrix that can adhere to inert or living surfaces. D-amino acids were previously identified as self-produced compounds that mediate biofilm disassembly by causing the release of the protein component of the polymeric matrix. However, whether exogenous D-amino ...
Reichert Robert R Institute of Surface Chemistry and Catalysis, Ulm University, D-89069 Ulm, Germany. - - 2014
A novel thin-layer photoelectrochemical flow cell allowing the online mass spectrometric detection of volatile reaction products during photoelectrocatalytic reactions has been developed and applied for separating the contributions from photoelectrochemical water splitting and photoelectrooxidation of formic acid to the overall photocurrent in formic acid containing aqueous solution, using a nanocrystalline ...
Subramanian Venkataramanan V National Renewable Energy Laboratory , Golden, Colorado 80401, United - - 2014
Chlamydomonas reinhardtii is well adapted to survive under different environmental conditions due to the unique flexibility of its metabolism. Here we report metabolic pathways that are active during acclimation to anoxia, but were previously not thoroughly studied under dark, anoxic H2-producing conditions in this model green alga. Proteomic analyses, using ...
Schurr Benjamin C BC Technische Universität München, Lehrstuhl für Technische Mikrobiologie, 85354 Freising, - - 2015
The main bittering component in beer, hop iso-α-acids, have been characterised as weak acids, which act as ionophores impairing microbial cells' function under acidic conditions as present in beer. Besides medium pH, divalent cations play a central role regarding the efficacy of the antimicrobial effect. The iso-α-acids' non-bitter derivatives humulinic ...
Matthaus B B a Max Rubner-Institut (MRI) Bundesforschungsinstitut für Ernährung und Lebensmittel Institut für Sicherheit und Qualität bei Getreide, Schützenberg 12 , D-32756 Detmold , - - 2014
The oil contents of safflower seeds ranged from 23.08% to 36.51%. The major fatty acid of safflower oil is linoleic acid, which accounted for 55.1-77.0% in oils, with a mean value of 70.66%. Three types of tocopherols were found in safflower oil in various amount α-tocopherol, β-tocopherol and γ-tocopherol, ranged ...
Blériot Yves Y Glycochemistry Group of "Organic Synthesis" Team, Université de Poitiers , UMR-CNRS 7285 IC2MP, Bât. B28, 4 rue Michel Brunet, TSA 51106, 86073 Poitiers Cedex 9, - - 2014
The first synthesis of 1,2-trans-homoiminosugars devised as mimics of β-d-GlcNAc and α-d-ManNAc is described. Key steps include a regioselective azidolysis of a cyclic sulfite and a β-amino alcohol skeletal rearrangement applied to a polyhydroxylated azepane. The β-d-GlcNAc derivative has been coupled to serine to deliver an iminosugar C-amino acid. The ...
Braid Jennifer L - - 2014
Phosphonic acid modification of zinc oxide (ZnO) electron transport layers in inverted P3HT:ICBA solar cells was studied to determine the effect of conjugated linkages between the aromatic and phosphonic acid attachment groups. For example, zinc oxide treated with 2,6-difluorophenylvinylphosphonic acid, having a conjugated vinyl group connecting the aromatic moiety to ...
Frömel Timo T Goethe University, Institute for Vascular Signalling, FRankfurt, Germany ; - - 2014
Significance: Cytochrome P450 (CYP) epoxygenases metabolize arachidonic acid to generate epoxyeicosatrienoic acids (EETs). The latter are biologically active and reported to act as an endothelium-derived hyperpolarizing factor as well as to affect angiogenic and inflammatory signaling pathways. Recent Advances: In addition to arachidonic acid, the CYP enzymes also metabolize the ...
Lin Chien-Yuan CY State Key Laboratory of Tree Genetics and Breeding, Northeast Forestry University, Harbin 150040, China Forest Biotechnology Group, Department of Forestry and Environmental Resources, North Carolina State University, Raleigh, North Carolina 27695, - - 2014
In a number of plant species, downregulation of 4-coumaric acid: coenzyme A ligase (4CL) can reduce lignin content. In lignin precursor (monolignol) biosynthesis during stem wood formation in Populus trichocarpa, two enzymes Ptr4CL3 and Ptr4CL5 catalyze the CoA ligation of 4-coumaric acid to 4-coumaroyl-CoA and caffeic acid to caffeoyl-CoA. CoA ...
Gesbert Gael G Université Paris Descartes, Sorbonne Paris Cité, Bâtiment Leriche. INSERM U1151 - CNRS UMR 8253, Institut Necker-Enfants Malades; Equipe 11: Pathogénie des Infections Systémiques, Paris, - - 2014
Intracellular bacterial pathogens have adapted their metabolism to optimally utilize the nutrients available in infected host cells. We recently reported the identification of an asparagine transporter required specifically for cytosolic multiplication of Francisella. In the present work, we characterized a new member of the Major Super Family (MSF) of transporters, ...
Okla Meshail M Department of Food Science and Human Nutrition, University of Florida, Gainesville, FL, USA; Department of Nutrition and Health Sciences, University of Nebraska, Lincoln, NE, - - 2014
Previously, we have reported that consumption of a muscadine grape phytochemical powder (MGP) decreased lipid accumulation in high-fat fed mice. The aim of this study was to identify the responsible polyphenolic constituents and elucidate the underlying mechanisms. In mice, MGP supplementation significantly reduced visceral fat mass as well as adipocyte ...
Wang Chuan C Department of Endocrinology, Qilu Hospital of Shandong University, Jinan, 250012, - - 2014
Irisin, a newly identified myokine responsible for browning of white or beige adipocytes, has been reported to be present at reduced levels in diabetic patients and associated with obesity, serum triglyceride (TG) levels, and intrahepatic TG levels. We wondered whether irisin could directly affect fatty acid and TG metabolism in ...
Chow Te-Jin TJ Department of Biotechnology, Fooyin University, Kaohsiung, - - 2014
In this work, a recombinant cyanobacterium strain with increased photosynthesis rate, cell growth and carbohydrate production efficiency was genetically engineered by co-expressing ictB, ecaA, and acsAB (encoded for bacterial cellulose) in Synechococcus elongatus PCC7942. The resulting cyanobacterial biomass could be effectively hydrolyzed with dilute acid (2% sulfuric acid), achieving a ...
M J Tomy T Inter University Centre for Bioscience, Department of Biotechnology and Microbiology, Kannur University, Thalassery Campus, Kannur, 670661, - - 2014
Piperine is a secondary metabolite of black pepper. Its uses in medicine were already studied. However, its derivatives have not gained considerable attention. In the presented study, the lipoxygenase (LOX) inhibitory activity of piperine and its derivatives, piperonylic acid, piperic acid, and piperonal have been assessed and compared by enzyme ...
Chen Lili L Department of Chemistry, Huaibei Normal University, Huaibei, Anhui 235000, P. R. China. - - 2014
A new protocol for Ru-catalyzed decarboxylative cyclization of mandelic acids with acrylates was established, which allows efficient construction of the phthalide skeleton. Interestingly, this reaction underwent a decarboxylative process, in which only divinylation was observed, and the subsequent cyclization led to the formation of phthalides.
Quang Tran Hong TH College of Pharmacy, Wonkwang University, Iksan 570-749, Republic of Korea; Institute of Marine Biochemistry, Vietnam Academy of Science and Technology (VAST), 18 Hoang Quoc Viet, Caugiay, Hanoi, Viet - - 2014
Chemical investigation of a marine-derived fungus Penicillium sp. SF-6013 resulted in the discovery of a new tanzawaic acid derivative, 2E,4Z-tanzawaic acid D (1), together with four known analogues, tanzawaic acids A (2) and D (3), a salt form of tanzawaic acid E (4), and tanzawaic acid B (5). Their structures ...
Wei Chenyu - - 2014
Flip-flop of protonated oleic acid molecules dissolved at two different concentrations in membranes made of 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine is studied with the aid of molecular dynamics simulations at a time scale of several microseconds. Direct, single-molecule flip-flop events are observed at this time scale, and the flip-flop rate is estimated at 0.2 ...
Krause André A Institute of Pharmacy and Molecular Biotechnology, Heidelberg University, Im Neuenheimer Feld 364, 69120 - - 2014
An optimized catalyst system of [Pd2 (dba)3 ] and AsPh3 efficiently catalyzes the Stille reaction between a diverse set of functionalized stannanes and halogenated mono-, di- and oligonucleotides. The methodology allows for the facile conjugation of short and long nucleic acid molecules with moieties that are not compatible with conventional ...
Baker Jillian Glenda JG University of Nottingham - - 2014
Salmeterol is a long-acting β2-agonist, widely used as an inhaled treatment for asthma and COPD. It has very high β2-affinity (log KD -8.95) and is very selective for the β2-adrenoceptor (1000-fold selectivity over the β1-adrenoceptor). This study used a mutagenesis approach to determine the exact amino acids in the human ...
Tonk Elisa C M EC Center for Health Protection National Institute for Public Health and the Environment (RIVM) P.O.Box 1 3720BA Bilthoven The - - 2014
Developmental toxicity can be caused through a multitude of mechanisms and can therefore not be captured through a single simple mechanistic paradigm. However, it may be possible to define a selected group of overarching mechanisms that might allow detection of the vast majority of developmental toxicants. Against this background, we ...
Bueno Fernanda Giacomini FG Departamento de Farmácia, Programa de Pós Graduação em Ciências Farmacêuticas, Universidade Estadual de Maringá, Av. Colombo, 5790, BR-87020-900 Maringá, - - 2014
Extracts from Poincianella pluviosa stem bark are used in traditional medicine of South America for its wound healing properties. For validation of this traditional use and for rationalizing a potential pharmaceutical development towards standardized preparations bioassay-guided fractionation of EtOH-water (1:1v/v) extract (crude extract, CE) of P. pluviosa bark was performed. ...
Flodrova D D Institute of Analytical Chemistry of the ASCR, v. v. i., Brno, Czech - - 2014
Retinoic acid (all-trans and 9-cis) isomers represent important therapeutic agents for many types of cancers, including human breast cancer. Changes in protein composition of the MCF-7 human breast cancer cells were induced by all-trans retinoic acid, 9-cis retinoic acid, and their combination and subsequently proteomic strategies based on bottom-up method ...
Zhang Huaiyuan H State Key Laboratory of Food Science and Technology, School of Food Science and Technology, Jiangnan University, Wuxi 214122, Jiangsu, PR - - 2014
Yarrowia lipolytica can accumulate large amounts of storage lipids and has considerable potential for the production of polyunsaturated fatty acids and other lipids for biofuels. When the nitrogen source is exhausted in the medium, the key intermediate, citrate, is converted to acetyl-CoA by ATP:citrate lyase (ACL) for lipid accumulation. However, ...
Kee Hae Jin HJ Heart Research Center of Chonnam National University Hospital, Gwangju 501-757, Republic of Korea. Electronic address: - - 2014
Vascular calcification is associated with increased risk of morbidity and mortality in patients with cardiovascular diseases, chronic kidney diseases, and diabetes. Gallic acid, a natural compound found in gallnut and green tea, is known to be antifungal, antioxidant, and anticancer. Here we investigated the effect of gallic acid on vascular ...
Feng Jingwei J School of Civil Engineering, Hefei University of Technology, Hefei, 230009, - - 2014
Degradation of aqueous 3,4-dichloroaniline (3,4-DCA) was conducted in a novel dielectric barrier discharge (DBD) plasma reactor. The factors affecting the degradation efficiency of 3,4-DCA and the degradation mechanism of 3,4-DCA were investigated. The experimental results indicated that the degradation efficiency of 3,4-DCA increased with increasing input power intensity, and the ...
He Yue Y Temasek Life Sciences Laboratory, 1 Research Link, 117604 Singapore Department of Biological Sciences, National University of Singapore, - - 2014
Excess fatty acids and sterols are stored as triacylglycerols and sterol esters in specialized cellular organelles, called lipid droplets. Understanding what determines the cellular amount of neutral lipids and their packaging into lipid droplets is of fundamental and applied interest. Using two species of fission yeast, we show that cycling ...
Chandran Suresh S Suresh Chandran, Department of Neonatology, KK Women's and Children's Hospital, Singapore 229899, - - 2014
The interplay between glucose metabolism and that of the two other primary nutrient classes, amino acids and fatty acids is critical for regulated insulin secretion. Mitochondrial metabolism of glucose, amino acid and fatty acids generates metabolic coupling factors (such as ATP, NADPH, glutamate, long chain acyl-CoA and diacylglycerol) which trigger ...
Vesprini Nicholas David ND Brock - - 2014
Retinoic acid, the active metabolite of Vitamin A, is important for nervous system development, regeneration as well as cognitive functions of the adult CNS. These CNS functions are all highly dependent on neuronal activity. Retinoic acid has previously been shown to induce changes in the firing properties and action potential ...
Negri Pierre P Department of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, IN 46556, USA. - - 2014
A sheath-flow surface-enhanced Raman scattering (SERS) detector is demonstrated to provide chemical information enabling identification of the 20 proteinogenic l-amino acids separated by capillary zone electrophoresis (CZE). Amino acids were used to illustrate the chemical specificity of SERS detection from structurally related molecules. Analysis of the SERS electropherograms obtained from ...
Yokoyama Takeshi - - 2014
Transthyretin (TTR) is a homo-tetrameric serum protein associated with amyloidoses such as familial amyloid polyneuropathy and senile systemic amyloidosis. The amyloid fibril formation of TTR can be inhibited through stabilization of the TTR tetramer by the binding of small molecules. In this study, we examined the inhibitory potency of caffeic ...
Huang Kewei K Department of Chemistry, ‡Department of Bioengineering, §Department of Materials and Nanoengineering, and ∥Institute of Bioscience and Bioengineering, Rice University , Houston, Texas 77005, United - - 2014
The use of photoluminescent probes for differentiating free amino acids from biomolecules containing the same amino acids is challenging. Photoluminescent probes generally present similar emission spectra when in the presence of either free-amino acids or protein containing those same amino acids. Probes based on cyclometalated iridium(III) complexes Ir(L)2(sol)2 (where L ...
Agostinelli Enzo E Istituto Pasteur-Fondazione Cenci Bolognetti Department of Biochemical Sciences 'A. Rossi Fanelli', Sapienza University of Rome and CNR, Institute of Biology and Molecular Pathology, 00185 Rome, - - 2014
Nanotechnology for cancer gene therapy is an emerging field. Nucleic acids, polyamine analogues and cytotoxic products of polyamine oxidation, generated in situ by an enzyme-catalyzed reaction, can be developed for nanotechnology-based cancer therapeutics with reduced systemic toxicity and improved therapeutic efficacy. Nucleic acid-based gene therapy approaches depend on the compaction of ...
Bellou Stamatia S Division of Genetics, Cell & Development Biology, Department of Biology, University of Patras, Patras 26504, - - 2014
In the last few years, there has been an intense interest in using microalgal lipids in food, chemical and pharmaceutical industries and cosmetology, while a noteworthy research has been performed focusing on all aspects of microalgal lipid production. This includes basic research on the pathways of solar energy conversion and ...
Li Shan-Shan SS Key Laboratory of Plant Resources and Beijing Botanical Garden, Institute of Botany, Chinese Academy of Sciences, Beijing 100093, China; University of Chinese Academy of Sciences, Beijing 100049, - - 2015
Seeds from Paeonia ostii and Paeoniarockii have been recently identified as novel resources of α-linolenic acid (ALA) in China. To assess whether tree peony cultivars can be used as oil resource, fatty acids (FAs) in 60 cultivars were monitored and evaluated in this study. The results indicated that the composition ...
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