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Wang Fen F State Key Laboratory of Fine Chemicals, Dalian University of Technology, Dalian, 116024, P. R. China. - - 2014
Acid-switching of the triplet excited state in rhodamine-C60 dyads was achieved. The rhodamine moiety acts as an acid-activated visible light-harvesting antenna and C60 as the singlet energy acceptor and the spin converter, and production of the triplet state was enhanced in the presence of acid.
Li Ruimin - - 2014
An efficient and facile synthesis method of nitrogen-doped mesoporous graphitic carbon (NMGC) was reported with melamine as a nitrogen source and citric acid as a carbon source. By taking advantage of the functional groups on melamine and citric acid, a uniform mixture of these two components was obtained via a ...
Matsumoto Naoki N Tokyo Noko University, - - 2014
Although ischemic stroke is a major cause of death and disability worldwide, only a small fraction of patients benefits from the current thrombolytic therapy due to a risk of cerebral hemorrhage caused by inflammation. Thus, the development of a new strategy to combat inflammation during thrombolysis is an urgent demand. ...
Yip Wai Lam WL School of Pharmacy, Department of Pharmacy, University of Oslo, P.O. Box 1068 Blindern, 0316, Oslo, Norway, - - 2014
The aim of current study was to investigate the influence of a common non-ionic surfactant, polysorbate 80 (PS80), on radioactive labelling process of a novel PET tracer, [(18)F]Flutemetamol. Ferrous oxidation-xylenol orange (FOX) assay, in addition to UV/VIS and (1)H NMR spectroscopies were applied to characterise the composition of the PS80 ...
Koynova Rumiana R Ohio State University College of Pharmacy 517 Parks Hall, 500 W 12th Ave Columbus, OH 43210, USA. - - 2014
The development of nucleic acid-based drugs has attracted considerable interest in the past two decades as a new category of biologics. A key challenge in successfully achieving the full potential of nucleotide therapeutics is their efficient delivery. Synthetic cationic lipids are currently the most extensively used non-viral nucleotide carriers because ...
Li Xin-Hua XH Department of Infectious Diseases, Ruijin Hospital, Shanghai Jiaotong University, School of Medicine, Shanghai, China; Chinese-French Laboratory of Life Science and Genomics, Ruijin Hospital, Shanghai Jiaotong University, School of Medicine, Shanghai, China; Institute of Infectious and Respiratory Diseases, Ruijin Hospital, Shanghai Jiaotong University, School of Medicine, Shanghai, China; Department of Infectious Diseases, The Third Affiliated Hospital of Sun-Yat-Sen University, GuangZhou, - - 2014
We studied two patients from a nonconsanguineous family with life-long abnormal liver function, hepatomegaly and abnormal fatty acid profiles. Abnormal liver function, hypoglycemia and muscle weakness are observed in various genetic diseases, including medium-chain acyl-CoA dehydrogenase (MCAD) deficiency and glycogen storage diseases. The proband showed increased free fatty acids, mainly ...
Song Yifan Y http://orcid.org/0000-0001-8064-3564 Cyrus Biotechnology, Inc., Seattle, WA 98101; - - 2014
Key mutations differentiate the functions of homologous proteins. One example compares the inward ion pump halorhodopsin (HR) and the outward proton pump bacteriorhodopsin (BR). Of the nine essential buried ionizable residues in BR, six are conserved in HR. However, HR changes three BR acids, D85 in a central cluster of ...
Mooranian Armin A Biotechnology and Drug Development Research Laboratory, School of Pharmacy, Curtin Health Innovation Research Institute, Biosciences Research Precinct, Curtin University , Perth, Western Australia , - - 2014
This study utilized the Seahorse Analyzer to examine the effect of the bile acid ursodeoxycholic acid (UDCA), on the morphology, swelling, stability, and size of novel microencapsulated β-cells, in real-time. UDCA was conjugated with fluorescent compounds, and its partitioning within the microcapsules was examined using confocal microscopy. UDCA produced microcapsules ...
Cao H L HL Key Laboratory for Ultrafine Materials of Ministry of Education, and Shanghai Key Laboratory of Advanced Polymeric Materials, School of Materials Science and Engineering, East China University of Science and Technology, Shanghai 200237, China. - - 2014
An acid labile branched PDMAEMA/acetal copolymer with amino group was synthesized by the DE-ATRP and followed by Michael addition. The degradation of the polymer was strongly pH-dependent. High nucleic acid transfection efficiency with low cytotoxicity was observed compared to its non-degradable copolymer counterpart.
Varlamov Oleg O Division of Diabetes, Obesity, and Metabolism and Developmental and Reproductive Science (O.V., C.T.R.), Division of Neuroscience (A.C.), Department of Medicine, Oregon National Primate Research Center, Beaverton, Oregon 97006; and Division of Endocrinology, Diabetes, and Clinical Nutrition (M.C., C.T.R.) and Center for Research on Environmental and Occupational Technology (H.S.), Oregon Health and Science University, Portland, Oregon - - 2014
Phenotypic diversity may play an adaptive role by providing graded biological responses to fluctuations in environmental stimuli. We used single-cell imaging, using the metabolizable fluorescent fatty acid analog 4,4-difluoro-4-bora-3a,4a-diaza-s-indacene (BODIPY)-C12 and fluorescent 2-[N-(7-nitrobenz-2-oxa-1,3-diazol-4-yl) amino]-2-deoxy-D-glucose, to explore cellular heterogeneity in nutrient uptake in white adipose tissue (WAT) explants of rhesus macaques. ...
Fritz Georg G LOEWE Center for Synthetic Microbiology, Philipps-University Marburg, 35043 Marburg, - - 2014
Bacterial cell wall homeostasis is an intricately coordinated process that ensures that envelope integrity is maintained during cell growth and division, but can also adequately respond to growth-limiting conditions such as phosphate starvation. In Bacillus subtilis, biosynthesis of the two major cell wall components, peptidoglycan and anionic polymers, is controlled ...
Buhrke Thorsten T Department of Food Safety, Federal Institute for Risk Assessment, Max-Dohrn-Str. 8-10, 10589, Berlin, Germany, - - 2014
The food contaminants 3-chloro-1,2-propanediol (3-MCPD) and 3-MCPD fatty acid esters have attracted considerable attention in the past few years due to their toxic properties and their occurrence in numerous foods. Recently, significant amounts of the isomeric compounds 2-chloro-1,3-propanediol (2-MCPD) fatty acid esters have been detected in refined oils. Beside the ...
Armstrong Alissa R AR Department of Biochemistry and Molecular Biology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD 21205, USA Division of Reproductive Biology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD 21205, - - 2014
How adipocytes contribute to the physiological control of stem cells is a critical question towards understanding the link between obesity and multiple diseases, including cancers. Previous studies have revealed that adult stem cells are influenced by whole-body physiology through multiple diet-dependent factors. For example, nutrient-dependent pathways acting within the Drosophila ...
Dato Laura - - 2014
BackgroundThe great interest in the production of highly pure lactic acid enantiomers comes from the application of polylactic acid (PLA) for the production of biodegradable plastics. Yeasts can be considered as alternative cell factories to lactic acid bacteria for lactic acid production, despite not being natural producers, since they can ...
Zacherl Janelle R JR Department of Pathology, University of Pittsburgh, Pittsburgh, PA, - - 2014
Artificial trans fatty acids promote atherosclerosis by blocking macrophage clearance of cell debris. Classical fatty-acid response mechanisms include TLR4-NF-κB activation, and Erk1/2 phosphorylation, but these may not indicate long-term mechanisms. Indeed, nuclear NF-κB was increased by 60 min treatment by 30 μM of the 18 carbon trans unsaturated fatty acid elaidic acid ...
Malik Abaid A Department of Physiology, University of Tuebingen, - - 2014
Background/Aims: Aristolochic Acid, a component of Aristolochia plants, has been shown to cause acute kidney injury, renal aristolochic acid nephropathy, Balkan endemic nephropathy, and urothelial carcinoma. Aristolochic acid nephropathy may be associated with severe anemia. The anemia could theoretically be due to stimulation of eryptosis, the suicidal death of erythrocytes ...
Vacanti Nathaniel M NM Department of Bioengineering, University of California, San Diego, La Jolla, CA 92093, - - 2014
Pyruvate lies at a central biochemical node connecting carbohydrate, amino acid, and fatty acid metabolism, and the regulation of pyruvate flux into mitochondria represents a critical step in intermediary metabolism impacting numerous diseases. To characterize changes in mitochondrial substrate utilization in the context of compromised mitochondrial pyruvate transport, we applied ...
Insomphun Chayatip C Department of Bioengineering, Graduate School of Bioscience and Biotechnology, Tokyo Institute of Technology, 4259 Nagatsuta, Midori-ku, Yokohama 226-8501, - - 2014
Poly((R)-3-hydroxybutyrate-co-(R)-3-hydroxyhexanoate) [P(3HB-co-3HHx)], a flexible and practical kind of polyhydroxyalkanoates, is generally produced from plant oils and fatty acids by several wild and recombinant bacteria. This study established an improved artificial pathway for the biosynthesis of P(3HB-co-3HHx) with high 3HHx composition from structurally unrelated fructose in Ralstonia eutropha. Depression of (R)-specific ...
Zhang Lizhi L School of Biological Sciences, Center for Reproductive Biology, Washington State University, Pullman, WA, 99164, - - 2014
The development of sink organs such as fruits and seeds strongly depends on the amount of nitrogen that is moved within the phloem from photosynthetic active source leaves to the reproductive sinks. In many plant species nitrogen is transported as amino acids. In pea (Pisum sativum L.) source to sink ...
Milecka Dorota D Department of Applied Microbiology, Faculty of Biology, University of Warsaw, Miecznikowa 1, 02-096, Warsaw, - - 2014
The expression of ten genes of Listeria monocytogenes previously identified as penicillin G-inducible was transcriptionally analyzed in the presence of 0.5 M KCl, pH 5.0 and 42 °C. This study revealed that all the genes are upregulated by osmotic stress, seven by acid stress and four by temperature stress conditions. The contribution ...
Hou Yucui - - 2014
Due to the similar properties and very low volatility, isomers of benzene polycarboxylic acids (BPCAs) are very difficult to separate. In this work, we found that isomers of BPCAs could be separated efficiently by quaternary ammonium salts (QASs) via forming deep eutectic solvents (DESs). Three kinds of QASs were used ...
Askari M M Department of Maxillofacial Pathology, Faculty of Dentistry, International Campus, Tehran University of Medical Sciences, Tehran, - - 2014
Oral squamous cell carcinoma (OSCC) is a remarkable health problem worldwide, but its pathogenesis remains unknown. The aim of this study was to compare fat composition and secretory phospholipase-A2 (sPLA2) activity between the malignant and adjacent normal squamous tissues in patients with OSCC. Paired samples of malignant squamous and adjacent ...
Kurimoto Kenta K Graduate School of Engineering, Nagoya Institute of Technology, Gokiso-cho, Showa-ku, Nagoya 466-8555, - - 2014
Cell-surface glycans containing sialic acid are involved in various biological phenomena. However, the syntheses of GM4 derivatives with (2→2) and (2→4) linkages have not been investigated to date. In this study, sialylation of all of the hydroxyl groups on galactose were investigated for the syntheses of GM4 isomers. Regioselective sialylation ...
Wang Zhongqiang Z William G. Lowrie Department of Chemical and Biomolecular Engineering, The Ohio State University, 140 W 19th Avenue, Columbus, OH 43210, - - 2014
Propionibacterium freudenreichii subsp. shermanii naturally forms propionic acid as the main fermentation product with acetate and succinate as two major by-products. In this study, overexpressing the native propionyl-CoA:succinate CoA transferase (CoAT) in P. shermanii was investigated to evaluate its effects on propionic acid fermentation with glucose, glycerol, and their mixtures ...
Powell William S WS Meakins-Christie Laboratories, Department of Medicine, McGill University, 3626St. Urbain Street, Montreal, Quebec H2X 2P2, Canada. Electronic address: - - 2014
Arachidonic acid can be oxygenated by a variety of different enzymes, including lipoxygenases, cyclooxygenases, and cytochrome P450s, and can be converted to a complex mixture of oxygenated products as a result of lipid peroxidation. The initial products in these reactions are hydroperoxyeicosatetraenoic acids (HpETEs) and hydroxyeicosatetraenoic acids (HETEs). Oxoeicosatetraenoic acids ...
Ueda Minoru M Laboratory of Organic Chemistry, Department of Chemistry, Tohoku University, 6-3 Aramaki-Aza Aoba, Aoba-ku, Sendai 980-8578, Japan. - - 2014
12-O-β-d-Glucopyranosyljasmonic acid (JAG, ) induces nyctinastic leaf-folding of Samanea saman. The SAR studies of revealed the unique role of its glycone moiety. Biological activity and the target affinity of were affected by the stereochemistry of the glycone moiety. JAG belongs to a unique class of ligands in which the structure ...
Jiang Nan N State Key Laboratory of Advanced Technology for Materials Synthesis and Processing, and School of Materials Science and Engineering, Wuhan University of Technology, Wuhan, 430070, China. xyyang@whut.edu.cn tian.ge@yahoo.com - - 2014
Amino acid-based biohybrids have been developed to self-assemble on the surface of desulfurizing bacteria to form nanothin and nanoporous shells. The shells not only endow the encapsulated cells with reusability, but also offer platforms to incorporate titania and magnetic nanoparticles to improve the desulfurizing activity and the separation efficiency.
Chalmers Benjamin A BA Faculty of Science and Engineering, Queensland University of Technology , P.O. Box 2434, 2 George Street, Brisbane, QLD 4001, - - 2014
We report the synthesis of a new class of molecules which are hybrids of long-lived tetramethylisoindolinoxyl (TMIO) radicals and the pyrido[1,2-a]benzimidazole (PyrImid) scaffold. These compounds represent a new lead for noncovalently binding nucleic acid probes, as they interact with nucleic acids with previously unreported C (DNA) and C/U (RNA) complementarity, ...
Yen Hong-Wei HW Department of Chemical and Materials Engineering, Tunghai University, Taiwan, ROC. Electronic address: - - 2014
The conversion of abundant lignocellulosic biomass (LCB) to valuable compounds has become a very attractive idea recently. This study successfully used LCB (rice straw) hydrolysate as a carbon source for the cultivation of oleaginous yeast-Rhodotorula glutinis in an airlift bioreactor. The lipid content of 34.3 ± 0.6% was obtained in an airlift ...
Yan Ziru Z School of Medicine, Zhejiang University, Hangzhou, - - 2014
The aim of this study was to investigate the transport of two kinds of bile acids by organic anion transporting polypeptide 1B3 (OATP1B3) using first-trimester trophoblasts. The mechanisms of damage to fetuses with intrahepatic cholestasis of pregnancy were investigated, providing new potential strategies for targeted therapies aimed at reducing fetal ...
Zanato Chiara C Kosterlitz Centre for Therapeutics, Institute of Medical Sciences, University of Aberdeen, Foresterhill, AB25 2ZD, Scotland, UK. - - 2014
(-)-Kainic acid potently increases stretch-induced afferent firing in muscle spindles, probably acting through a hitherto uncloned phospholipase D (PLD)-coupled mGlu receptor. Structural modification of (-)-kainic acid was undertaken to explore the C-4 substituent effect on the pharmacology related to muscle spindle firing. Three analogues were synthesised by highly stereoselective additions ...
Agasti Soumitra S Department of Chemistry, Indian Institute of Technology Bombay, Powai, Mumbai-400076, India. - - 2014
A palladium catalyzed intermolecular annulation of cinnamic acids and phenols has been achieved for the selective synthesis of 3-substituted benzofurans. Isotope labeling, competition experiments, kinetic studies, and intermediate trapping have supported a sequence of C-C bond formation and decarboxylation followed by the C-O cyclization pathway.
Li Jie - - 2014
CuInS2 nanorods and networks are interesting candidates for applications requiring efficient charge transport, such as, solar energy conversion, because of the increased electrical conductivity in elongated or interconnected nanocrystals, compared to isolated, quasi-spherical ones. However, little is known about the growth mechanisms involved in the formation of this kind of ...
Myeong Jongyun J Seoul National University College of Medicine, Korea, Republic - - 2014
Canonical transient receptor potential (TRPC) channels are Ca(2+)-permeable nonselective cation channels that are activated by a wide variety of stimuli, including G protein-coupled receptors (GPCRs). The TRPC4 channel is expressed in a punctate distribution in the membrane. To identify the regulating region of the channel trafficking to the membrane, we ...
Brett Katharina K Free University Berlin, - - 2014
S-acylation of hemagglutinin (HA), the main glycoprotein of Influenza viruses, is an essential modification required for virus replication. Using mass spectrometry we have previously demonstrated specific attachment of acyl chains to individual acylation sites. Whereas the two cysteines in the cytoplasmic tail of HA contain only palmitate, stearate is exclusively ...
Insaward Anchana - - 2014
This study aimed to explore the effect of phenolic acid addition on properties of soy protein film. Ferulic (FE), caffeic (CA) and gallic (GA) acids as well as their oxidized products were used in this study. Phenolic acid addition was found to pose a significant effect (p≤0.05) on mechanical properties ...
Choi Woo-Suk WS Department of Microbiology, College of Natural Sciences, Pukyong National University, Busan 608-737, Republic of - - 2014
In the present study, we investigated regulatory effects of veratric acid on the production of nitric oxide (NO) in lipopolysaccharide (LPS)-stimulated RAW264.7 cells. NO production was significantly decreased by veratric acid in the LPS-stimulated RAW264.7 cells in a dose-dependent manner. The reduction in nitric oxide production was induced by the ...
Han Lin L School of Environmental Science and Engineering, Shandong University, 27 Shanda Nan Road, Jinan 250100, - - 2014
The notion of wastewater treatment combined with biomass production is potential and prospective. Campus sewage was utilized twice in procession to cultivate the newly isolated microalgae Scenedesmus quadricauda SDEC-13. Nutrients was efficiently removed with the phosphorus and nitrogen removal efficiency nearly 100% and more than 70% respectively in twice use ...
Mookerjee Shona A SA College of Pharmacy, Touro University California, 1310 Club Drive, Vallejo, CA 94592, USA; Buck Institute for Research on Aging, 8001 Redwood Blvd, Novato, CA 94945, USA. Electronic address: - - 2014
The rate at which cells acidify the extracellular medium is frequently used to report glycolytic rate, with the implicit assumption that conversion of uncharged glucose or glycogen to lactate(-)+H(+) is the only significant source of acidification. However, another potential source of extracellular protons is the production of CO2 during substrate ...
Miyamoto Kensuke K Faculty of Liberal Arts and Sciences, Osaka Prefecture University, 1-1 Gakuen-cho, Naka-ku, Sakai, Osaka 599-8531, Japan. Electronic address: - - 2014
Hyacinth (Hyacinthus orientalis) bulbs infected by Fusarium oxysporum showed the symptoms of gummosis. The purpose of this study was to clarify the hormonal regulation of gummosis and composition of gums from hyacinth bulbs. The application of ethephon (2-chloroethylphosphonic acid), an ethylene-releasing compound, at 2% (w/w, in lanolin) induced gummosis in ...
Ullah Anwar A Department of Physics, UNESP/IBILCE, Rua Cristovão Colombo 2265, São José Do Rio Preto, São Paulo 15054-000, - - 2014
Snake-venom proteins form multi-component defence systems by the recruitment and rapid evolution of nonvenomous proteins and hence serve as model systems to understand the structural modifications that result in toxicity. L-Amino-acid oxidases (LAAOs) are encountered in a number of snake venoms and have been implicated in the inhibition of platelet ...
Li Miao M Department of Pharmaceutical Sciences, Beijing Institute of Radiation Medicine, Beijing 100850, - - 2014
Lipid derivatives of nucleoside analogs and their nanoassemblies have become the research hotspot due to their unique function in cancer therapy. Six lipid derivatives of 3'-hydroxyurea-deoxythymidine were prepared with zidovudine as the raw material. The 5'-substituted lipid chains in the derivatives were from the various fatty acids including octanoic acid, ...
Sagrillo Michele Rorato MR Programa de Pós-Graduação em Farmacologia, Universidade Federal de Santa Maria, Av. Roraima 1000, Prédio 21, 97105-900 Santa Maria, RS, Brazil; Centro Universitário Franciscano, Rua dos Andradas, 1614, 97010-032 Santa Maria, RS, Brazil; Laboratório de Biogenômica, Departamento de Morfologia, Centro de Ciências da Saúde, Universidade Federal de Santa Maria, Av. Roraima, 1000 Prédio 19, 97105-900 Santa Maria, RS, Brazil. Electronic address: - - 2015
This study quantifies the bioactive molecules in and determines the in vitro protective effect of ethanolic extracts isolated from the peel and pulp of tucumã (Astrocaryum aculeatum, Mart.), an Amazonian fruit rich in carotenoids. The cytoprotective effect of tucumã was evaluated in lymphocyte cultures exposed to H2O2 using spectrophotometric, fluorimetric, ...
Liu Jiao J Marine Bioengineering Group, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 16023, China; University of Chinese Academy of Sciences, Beijing 100049, - - 2014
Transesterification of lipids is a vital step during the processes of both biodiesel production and fatty acid analysis. By comparing the yields and fatty acid profiles obtained from microalgal oil and dry microalgal cells, the reliability of method for the transesterification of micro-scale samples was tested. The minimum amount of ...
Manjappa Kiran B KB Department of Chemistry, Tunghai University , No. 1727, Sec. 4, Taiwan Boulevard, Xitun District, Taichung City 40704, Taiwan, Republic of - - 2014
A microwave-promoted, metal- and catalyst-free decarboxylative α,β-difunctionlization of secondary α-amino acids via a pseudo-four-component coupling of proline, aldehyde, and 1,3-diketone to generate multifunctionalized pyrano[2,3-b]pyrrole and pyrrolizinone derivatives is reported.
He Sha S Beijing Engineering Research Center for BioNanotechnology & CAS Key Laboratory for Biological Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology, Beijing 100190, China. xingyujiang@nanoctr.cn - - 2014
This work develops a high-throughput, high-efficiency and straightforward microfluidic blotting method for analyzing proteins and nucleic acids. Sample solutions containing antibodies (for protein detection) or hybridization probes (for nucleic acid detection) are introduced into the parallel, serpentine microchannels to specifically recognize the immobilized targets on the substrate, achieving the identification ...
Ercan Onur O Kluyver Centre for Genomics of Industrial Fermentation, P.O. Box 5057, 2600 GA Delft, The Netherlands Top Institute Food and Nutrition, Nieuwe Kanaal 9A, 6709 PA Wageningen, The Netherlands Laboratory of Microbiology, Wageningen University, P.O. Box 8033, 6700 EJ Wageningen, The Netherlands NIZO food research, P.O. Box 20, 6710 BA Ede, The - - 2014
This paper describes the molecular and metabolic adaptations of Lactococcus lactis during the transition from a growing to a near-zero growth state using carbon-limited retentostat cultivation. Transcriptomic analyses revealed that metabolic patterns shifted between lactic- and mixed-acid fermentation during retentostat cultivation, which appeared to be controlled at the transcription level ...
Zaprasis Adrienne A Philipps-University Marburg, Department of Biology, Laboratory for Microbiology, Karl-von-Frisch-Str. 8, D-35043 Marburg, - - 2014
The data presented here reveal a new facet of the physiological adjustment processes through which Bacillus subtilis can derive osmostress protection. We found that the import of proteogenic (Glu, Gln, Asp, Asn, Arg) and of non-proteogenic (Orn and Cit) amino acids, and their metabolic conversion into proline enhances growth under ...
Lee Wing-Hin WH Advanced Drug Delivery Group, Faculty of Pharmacy, University of Sydney, NSW, 2006, Australia; Respiratory Technology, Woolcock Institute of Medical Research, NSW, 2006, - - 2014
Interactions between proteins and the surface of biomaterials are crucial for the biological function and success of materials implanted in the human body. In this study, hydroxyapatite (HA) with negative and positive surface charges were fabricated by functionalizing the HA surface with acidic or basic amino acids. The influence of ...
Wright Matthew E ME Department of Chemistry and ‡Tennessee Center for Botanical Medicine Research, Middle Tennessee State University , Murfreesboro, Tennessee 37132, United - - 2014
Components previously reported from Cyclocarya paliurus include the oleananes cyclocaric acids A and B, with cyclocaric acid A possessing an oxetane ring. Isolation of cyclocaric acid A from the plant extract and comparison to the literature report show that the compound originally reported as cyclocaric acid A is, in fact, ...
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