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Xue Pengchong P State Key Laboratory of Supramolecular, Structure and Materials, College of Chemistry, Jilin University, No. 2699 Qianjin Street, Changchun (China). - - 2014
Two L-phenylalanine derivatives with 5,8-bis(2-(carbazol-3-yl)vinyl)quinoxaline (PCQ) and 5,8-bis[2-(carbazol-3-yl)]-2,3-dimethylquinoxaline (DCQ) as fluorophores were synthesized, and their photophysical properties were measured and compared. The two compounds were found to gelate some organic solvents and self-assemble into 1D nanofibers in gels. The wet gel of PCQ emitted a weak orange fluorescence, but the ...
Gong Jinyan J 1 Zhejiang Provincial Key Lab for Chem & Bio Processing Technology of Farm Produces, School of Biological and Chemical Engineering, Zhejiang University of Science and Technology , Hangzhou, People's Republic of China - - 2014
Abstract This study was designed to detect characteristic compounds and evaluate the free radical scavenging capacity of the bamboo leaves extract and bamboo shavings extract (BSE). The antioxidant capacity of bamboo leaf n-butanol fraction (AOB) exhibited the highest total phenolic content (49.93%), total flavonoids content (24.11%), and characteristic flavonoids and ...
Fuentes Eduardo E Faculty of Health Sciences, Department of Clinical Biochemistry and Immunohaematology, Interdisciplinary Excellence Research Program on Healthy Aging (PIEI-ES), Universidad de Talca, Talca, Chile; Centro de Estudios en Alimentos Procesados (CEAP), CONICYT-Regional, Gore Maule R09I2001, Chile. Electronic address: - - 2014
An endothelial dysfunction generates a proatherogenic environment characterized by stimulating thrombus formation. Epidemiological studies have provided evidence of a protective role of healthy diets in the prevention of cardiovascular diseases. Hydroxycinnamic acids constitute abundant polyphenols in our diets as they are present in high levels in many widely consumed foods, ...
Bazinet Richard P RP Department of Nutritional Sciences, University of Toronto, Toronto, Ontario M5S 3E2, - - 2014
The brain is highly enriched with fatty acids. These include the polyunsaturated fatty acids (PUFAs) arachidonic acid and docosahexaenoic acid, which are largely esterified to the phospholipid cell membrane. Once PUFAs are released from the membrane, they can participate in signal transduction, either directly or after enzymatic conversion to a ...
Köstereli Ziya Z Institut des Sciences et Ingénierie Chimiques, Ecole Polytechnique Fédérale de Lausanne (EPFL), 1015 Lausanne, Switzerland. - - 2014
An amphiphilic fluorescent dye with a disulfonated BODIPY head group and a heptadecyl side chain is described. In buffered aqueous solution, the amphiphile can form aggregates with a critical micelle concentration of ∼20 μM. The aggregation of the dye is associated with a strong quenching of its fluorescence. Al(3+) promotes ...
Panitchob N N Bioengineering Science Research Group, Faculty of Engineering and the Environment, University of Southampton, Southampton, - - 2014
Placental amino acid transport is required for fetal development and impaired transport has been associated with poor fetal growth. It is well known that placental amino acid transport is mediated by a broad array of specific membrane transporters with overlapping substrate specificity. However, it is not fully understood how these ...
Bekbolet M M Institute of Environmental Sciences, Bogazici University, 34342 Bebek, Istanbul, Turkey. - - 2014
The influence of photocatalytic degradation on molecular size fractionation (0.45 μm filtered, 100 kDa, 30 kDa and 3 kDa) of humic acid as a model compound of natural organic matter was investigated. The results were evaluated using UV-vis parameters, dissolved organic carbon (DOC) and excitation emission matrix (EEM) fluorescence spectral ...
Shannon D Alexander DA Department of Chemistry, Boston College, Chestnut Hill, MA 02467, United - - 2014
Functional amino acids that play critical roles in catalysis and regulation are known to display elevated nucleophilicity and can be selectively targeted for covalent modification by reactive electrophiles. Chemical-proteomic platforms, such as activity-based protein profiling (ABPP), exploit this reactivity by utilizing chemical probes to covalently modify active-site residues to inform ...
Dishisha Tarek T Department of Biotechnology, Center for Chemistry and Chemical Engineering, Lund University, P.O. Box 124, SE-221 00 Lund, - - 2014
Propionic acid was produced from glycerol using Propionibacterium acidipropionici. In this study, the impact of the concentrations of carbon and nitrogen sources, and of different modes of high cell density fermentations on process kinetics and -efficiency was investigated. Three-way ANOVA analysis and batch cultivations at varying C/N ratios at pH ...
Romanias Manolis N - - 2014
The interaction of propionic and butyric acids on ice and HNO3-doped ice were studied between 195 and 212 K and low concentrations, using a Knudsen flow reactor coupled with a quadrupole mass spectrometer. The initial uptake coefficients (γ0) of propionic and butyric acids on ice as a function of temperature ...
Wu Qinglong Q Food and Nutritional Science, School of Biological Sciences, The Univ. of Hong Kong, Pokfulam Road, Hong - - 2014
The consumption of trans fatty acids (TFAs) increases the risk of cardiovascular diseases and coronary heart disease in human, and there are no effective ways to remove TFAs after consumption. The aim of this study was to investigate the effects of elaidic acid on bacterial growth, cell surface hydrophobicity of ...
Jia Yaoyao Y Department of Biotechnology, Graduate School of Biotechnology, Korea University, Room 410, College of Life Sciences & Biotechnology EAST Bldg, Anam-5-ga, 136-713, Seoul, Republic of - - 2014
Dipeptides absorbed by the intestinal epithelium are delivered to circulation, but their metabolic roles are not yet clearly understood. We investigated the biological activities of a dietary dipeptide, H-Trp-Arg-OH (WR), on the regulation of peroxisome proliferator-activated receptor (PPAR) α activity. Reporter gene assays revealed that WR dose-dependently induced PPARα transactivation. ...
Ponzano Stefano - - 2014
N-(2-oxo-3-oxetanyl)carbamic acid esters have recently been reported to be noncompetitive inhibitors of the N-acylethanolamine acid amidase (NAAA) potentially useful for the treatment of pain and inflammation. In the present study, we further explored the structure activity relationships of the carbamic acid ester side chain of 2-methyl-4-oxo-3-oxetanylcarbamic acid ester derivatives. Additional ...
Pizzonero Mathieu - - 2014
FFA2, also called GPR43, is a G-protein coupled receptor for short chain fatty acids which is involved in the mediation of inflammatory responses. A class of azetidines was developed as potent FFA2 antagonists. Multi-parametric optimization of early hits with moderate potency and suboptimal ADME properties led to the identification of ...
El-Faham Ayman A Department of Chemistry, College of Science, King Saud University, PO Box 2455, Riyadh 11451, Saudi Arabia; Chemistry Department, Faculty of Science, Alexandria University, PO Box 426, Ibrahimia, 12321 Alexandria, Egypt. Electronic address: - - 2014
α-Ketoamino acid ester 2-[2-(2-acetamidophenyl)-2-oxoacetamido] and 2-[4-(2-(2-acetamidophenyl)-2-oxoacetamido)benzamido] derivatives were synthesized via the ring opening of N-acetylisatin under mild conditions. These compounds were then examined for their capacity to inhibit monoamine oxidase (MAO). The inhibition profile was found to be competitive for compounds 4d, 6a, 6b and 6f, which showed MAO-A selectivity. ...
Shi Wei W a Department of Chemistry , Zhejiang University , Hangzhou 310027 , - - 2014
In this study, a series of triazole substituted betulin and betulinic acid derivatives was designed and synthesized via click chemistry at C-30 position. Eighteen target compounds were evaluated in vitro for their antitumor activities against leukemia cell-line HL-60. Seventeen compounds have not reported before. The cytotoxic experiment showed that most ...
Shrestha Roshan P RP Scripps Institution of Oceanography, University of California San Diego, La Jolla, California, - - 2014
The utilization of silicon by diatoms has both global and small scale implications, from oceanic primary productivity to nanotechnological applications of their silica cell walls. The sensing and transport of silicic acid is a key aspect of understanding diatom silicon utilization. At low silicic acid concentrations (<30 μM) transport mainly ...
Dansey Maria Virginia - - 2014
Dafachronic acids (DAs) are 3-keto colestenoic acids bearing a carboxylic acid moiety at the end of the steroid side chain. These compounds interact with the DAF-12 receptor, a ligand dependent transcription factor that acts as a molecular switch mediating the choice between arrest at diapause or progression to reproductive development ...
Lemaitre Rozenn N RN University of Washington, United States; - - 2014
Very long-chain saturated fatty acids (VLSFA) are saturated fatty acids with 20 or more carbons. In contrast to the more abundant saturated fatty acids, such as palmitic acid, there is growing evidence that circulating VLSFA may have beneficial biological properties. Whether genetic factors influence circulating levels of VLSFA is not ...
Wagner Carsten A CA Institute of Physiology, University of Zurich, Zurich, - - 2014
Aldosterone is classically associated with the regulation of salt and potassium homeostasis but has also profound effects on acid-base balance. During acidosis, circulating aldosterone levels are increased and the hormone acts in concert with angiotensin II and other factors to stimulate renal acid excretion. Pharmacological blockade of aldosterone action as ...
Rukachaisirikul Vatcharin V Department of Chemistry and Center of Excellence for Innovation in Chemistry, Faculty of Science, Prince of Songkla University , Hat Yai, Songkhla 90112, - - 2014
Purification of an extract from the broth of the soil fungus Aspergillus sp. PSU-RSPG185 resulted in the isolation of two new cyclic carbonate derivatives, aspergillusols A (1) and B (2), and one new eutypinic acid derivative, aspergillusic acid (3), along with six known secondary metabolites. Compounds 1 and 2 contain ...
Lamounier-Zepter V V Clinical Medicine III, Dresden University of Technology, Dresden, - - 2014
Background:Adipocyte fatty acid-binding protein (FABP4) is a member of a highly conserved family of cytosolic proteins that bind with high affinity to hydrophobic ligands such as saturated and unsaturated long-chain fatty acids and eicosanoids. Recent evidence has supported a novel role for FABP4 in linking obesity with metabolic and cardiovascular ...
Bai Yunpeng - - 2014
This study determined the fate of deoxyanthocyanidins in sorghum sourdoughs. Sourdoughs prepared from the red sorghum variety Town was fermented with the caffeic acid- decarboxylating strains Lactobacillus plantarum FUA3171 and the decarboxylase negative L. casei FUA3166. Deoxyanthocyanidins were analysed by LC-MS/MS. Apigeninidin and methoxyapigeninidin were the major deoxyanthocyanidins prior to ...
Kumar N Mithil NM a Composites Research Group , Department of Mechanical - - 2014
ABSTRACT Polyaspartic acid (PSI) is suitable for the inhibition of inorganic scale deposition. To enhance its scale inhibition efficiency, PSI was modified by reacting aspartic acid (ASP) with malic acid (MA) using thermal polycondensation polymerization. This reaction resulted in poly (aspartic acid-co-malic acid) (PSI-co-MA) dual polymer. The structural, chemical and ...
Toops Kimberly A KA Department of Ophthalmology and Visual Sciences, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI, USA McPherson Eye Research Institute, University of Wisconsin-Madison, Madison, WI, - - 2014
Autophagy is an essential mechanism for clearing damaged organelles and proteins within the cell. As with neurodegenerative diseases, dysfunctional autophagy could contribute to blinding diseases like macular degeneration. However, precisely how inefficient autophagy promotes retinal damage is unclear. Here, we investigate innate mechanisms that modulate autophagy in the retinal pigment ...
Acharyya Koushik K Department of Inorganic and Physical Chemistry, Indian Institute of Science, Bangalore 560012, India. - - 2014
Dynamic covalent imine chemistry has been utilized to synthesize a fluorescent [3+2] self-assembled nanoscopic organic cage. The fluorescent nature of the reduced analogue of the cage was further exploited for the highly selective detection of the explosive picric acid (PA).
Rigano Maria Manuela - - 2014
Solanum lycopersicum represents an important source of antioxidants and other bioactive compounds. We previously identified two Solanum pennellii introgression lines (IL 7-3 and IL 12-4) carrying Quantitative Trait Loci (QTL) increasing fruit ascorbic acid and phenolics content. Novel tomato lines were obtained by pyramiding these selected QTLs in the genetic ...
Gomez-Hernandez Mario - - 2014
The heterogeneous chemistry of glyoxal on sulfuric acid surfaces has been investigated at various acid concentrations and temperatures, utilizing a low-pressure fast flow laminar reactor coupled to an ion drift - chemical ionization mass spectrometer (ID-CIMS). The uptake coefficient (γ) of glyoxal ranges from (1.2 ± 0.06) x 10-2 to ...
Snyder Nathaniel W NW University of Pennsylvania, Department of Pharmacology and Center of Excellence in Environmental Toxicology, Philadelphia, PA 19104, - - 2014
Bioactive lipids govern cellular homeostasis and pathogenic inflammatory processes. Current dogma holds that bioactive lipids, such as prostaglandins and lipoxins, are inactivated by 15-hydroxyprostaglandin dehydrogenase (15PGDH). In contrast, the present results reveal that catabolic "inactivation" of hydroxylated polyunsaturated fatty acids (PUFAs) yields electrophilic α,β-unsaturated ketone derivatives. These endogenously produced species ...
Bastos Claudete C Mountain Research Center (CIMO), ESA, Polytechnic Institute of Bragança, Campus de Santa Apolónia, 1172, 5301-855 Bragança, - - 2015
The aim of this study was to characterise sweet cherry regarding nutritional composition of the fruits, and individual phytochemicals and bioactive properties of fruits and stems. The chromatographic profiles in sugars, organic acids, fatty acids, tocopherols and phenolic compounds were established. All the preparations (extracts, infusions and decoctions) obtained using ...
Rünzi Thomas T Chair of Chemical Materials Science, Department of Chemistry, University of Konstanz, Universitätsstrasse 10, 78457, Konstanz, - - 2014
Insertion of diethyl vinyl phosphonates and free vinyl phosphonic acid, respectively, into [(P^O)Pd(Me)(dmso)] ((P^O) =κ(2) -P,O-Ar2 PC6 H4 SO2 O with Ar = 2-MeOC6 H4 ) (1-dmso) occurs in a 2,1- as well as 1,2-fashion, to form a four-and a five-membered chelate [(P^O)Pd{κ(2) -C,O-CH(P(O)(OR)2 )CH2 CH3 }] and [(P^O)Pd{κ(2) -C,O-CH2 ...
Carpy Alejandro A University of Tuebingen, - - 2014
Stable Isotope Labeling by Amino Acids (SILAC) is a commonly used method in quantitative proteomics. Due to compatibility with trypsin digestion, arginine and lysine are the most widely used amino acids for SILAC labeling. We observed that Schizosaccharomyces pombe (fission yeast) cannot be labeled with a specific form of arginine, ...
Else Paul L PL School of Medicine (Lipid Research Centre in IHMRI), University of Wollongong, 2522, Australia. Electronic address: - - 2014
Peroxidation is a well-known natural phenomenon associated with both health and disease. We compared the peroxidation kinetics of phosphatidylcholine (PC) molecules with different fatty acid compositions (i.e. 18:0, 18:1n-9, 18:2n-6, 20:4n-6 and 22:6n-3 at the sn-2 and 16:0 at sn-1 position) either as molecules free in solution or formed into ...
Moukha-Chafiq Omar O a Southern Research Institute , Drug Discovery Division , Birmingham , Alabama , - - 2014
A small library of fifty-five adenosine peptide analogs was synthesized, under the Pilot Scale Library (PSL) Program of the NIH Roadmap initiative, from 2',3'-O-isopropylideneadenosine-5'-carboxylic acid 2. The coupling of amine or sulfanilamide reactants to the free 5'-carboxylic acid moiety of 2, in automated solution-phase fashion, led after acid-mediated hydrolysis to ...
Petrosino Stefania S Epitech Group S.r.l., Saccolongo, PD, Italy; Endocannabinoid Research Group, Istituto di Chimica Biomolecolare, C.N.R., Pozzuoli, NA, - - 2014
Palmitoylethanolamide (PEA) is produced by mammalian cells from its biosynthetic precursor, N-palmitoyl-phosphatidyl-ethanolamine, and inactivated by enzymatic hydrolysis to palmitic acid and ethanolamine. Apart from fatty acid amide hydrolase (FAAH), the N-acylethanolamine-hydrolyzing acid amidase (NAAA), a lysosomal enzyme, was also shown to catalyze the hydrolysis of PEA and to limit its ...
Lee Ju Young JY Biomaterials Laboratory, Samsung Advanced Institute of Technology, Gyeonggi-do, - - 2014
Owing to the growing market for the biodegradable and renewable polymer, polylactic acid, world demand for lactic acid is rapidly increasing. However, the very high concentrations desired for industrial production of the free lactic acid create toxicity and low pH concerns for manufacturers. Saccharomyces cerevisiae is the most well characterized ...
Arunachalam Ramaiah R Sri Paramakalyani Centre for Environmental Sciences, Manonmaniam Sundaranar University, Alwarkurichi 627 412, Tamil Nadu, India; Centre for Infectious Disease Research, Indian Institute of Science, Bangalore 560 012, India(1). Electronic address: - - 2014
In China, the recent outbreak of novel influenza A/H7N9 virus has been assumed to be severe, and it may possibly turn brutal in the near future. In order to develop highly protective vaccines and drugs for the A/H7N9 virus, it is critical to find out the selection pressure of each ...
Malkar Vishwabharati V VV Radiation & Photochemistry Division, Bhabha Atomic Research Centre, Trombay, Mumbai 400 085, - - 2014
Formation of silver nanoparticles in the presence of various aminipolycarboxylic acids (APCAs) such as iminodiacetic acid (IDA), nitrilotriacetic acid (NTA), ethylenediaminetetraacetic acid (EDTA), N-(2-hydroxyethyl) ethylenediaminetriacetic acid (HEDTA), diethylenetriaminepentaacetic acid (DTPA), and N,N,N',N″,N‴,N‴-triethylenetetraminehexaacetic acid (TTHA) was studied. Monodispersed silver nanoparticles capped by carboxylate groups of APCAs were prepared by the reduction ...
Shichiri Mototada M Health Research Institute (HRI), National Institute of Advanced Industrial Science and Technology (AIST), 2217-14 Hayashi-cho, Takamatsu, Kagawa 761-0395, - - 2014
An increase in the proportion of fatty acids with higher numbers of double bonds is believed to increase lipid peroxidation, which augments the risk for many chronic diseases. (n-3) Polyunsaturated fatty acids provide various health benefits, but there is a concern that they might increase lipid peroxidation. We examined the ...
Jiang Ping P The MOE Key Laboratory for Standardization of Chinese Medicines, The SATCM Key Laboratory for New Resources and Quality Evaluation of Chinese Medicines and Shanghai Key Laboratory of Complex Prescription, Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, - - 2014
This study aims to observe the protective action of Flos Lonicerae (FL) aqueous extract against acetaminophen (AP)-induced liver injury and its mechanism. Results show that FL decreases AP-increased serum alanine/aspartate transaminases (ALT/AST) activity, as well as total bilirubin (TB) amount, in mice. Histological evaluation of the liver further confirms the ...
Irzik Kristina K Institute of Bio- and Geosciences, IBG-1: Biotechnology, Forschungszentrum Jülich, - - 2014
Corynebacterium glutamicum, like Mycobacterium tuberculosis, is a member of the Corynebacteriales, which have linear fatty acids and as branched fatty acids the mycolic acids. We identified accD1 and fasA as key genes of fatty acid synthesis, encoding the β-subunit of the acetyl-CoA carboxylase and a type-I fatty acid synthase, respectively, ...
Ioroi Tadaaki T Department of Pharmacology, Graduate School of Pharmaceutical Sciences, Kyoto University, - - 2014
We previously reported that serofendic acid, a lipophilic extract of fetal calf serum, protects against oxidative stress in primary culture of neonatal rat cardiomyocytes. However, the effect of serofendic acid on myocardial ischemia-reperfusion injury in vivo is yet to be determined. In the present study, we investigated the effect of ...
Wang Yaxing - - 2014
BackgroundRecent efforts demonstrated the potential application of cyanobacteria as a ¿microbial cell factory¿ to produce butanol directly from CO2. However, cyanobacteria have very low tolerance to the toxic butanol, which limits the economic viability of this renewable system.ResultsThrough a long-term experimental evolution process, we achieved a 150% increase of the ...
Li Xiaojing X Key Laboratory of Structure-Based Drug Design & Discovery of Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, PR - - 2014
A novel series of elemonic acid derivatives were synthesized and evaluated for their inhibitory activity on Pin1. Five compounds displayed significantly improved ability to inhibit Pin1 activity at micromolar levels. Compound 10 with 2-carboxylmethylene was the most active one with an IC50 value of 0.57μM. The docking models of Pin1 ...
Tremblay Hugo H Institut de Pharmacologie de Sherbrooke, 3001, 12e av nord, Sherbrooke (Qc) J1H 5N4, - - 2014
A one-pot environmentally friendly transamidation of ω-3 fatty acid ethyl esters to amides and mono- or diacylglycerols was investigated via the use of a polymer-supported lipase. The method was used to synthesize a library of fatty acid monoglyceryl esters and amides. These new derivatives were found to have potent growth ...
Kamoun Jannet J University of Sfax, ENIS - Laboratory of Biochemistry and Enzymatic Engineering of Lipases, 3038 Sfax, - - 2014
Yarrowia lipolytica is a lipolytic yeast possessing 16 paralog genes coding for lipases. Little information on these lipases has been obtained and only the major secreted lipase, namely YLLIP2, had been biochemically and structurally characterized. Another secreted lipase, YLLIP8, was isolated from Y. lipolytica culture medium and compared with the ...
Zhou Zhifang Z Department of Chemistry, Wayne State University, Detroit, Michigan 48202, - - 2014
A convenient method was developed for the quantification of sialic acids expressed by cells and used to analyze the efficiency of N-phenylacetyl-D-mannosamine (ManNPhAc) to metabolically glycoengineer SKMEL-28 cancer cell. For this purpose, ManNPhAc-cultured cells were treated with 2M acetic acid to release sialic acids, and the products were treated with ...
Li Ruimin - - 2014
An efficient and facile synthesis method of nitrogen-doped mesoporous graphitic carbon (NMGC) was reported with melamine as a nitrogen source and citric acid as a carbon source. By taking advantage of the functional groups on melamine and citric acid, a uniform mixture of these two components was obtained via a ...
Li Xin-Hua XH Department of Infectious Diseases, Ruijin Hospital, Shanghai Jiaotong University, School of Medicine, Shanghai, China; Chinese-French Laboratory of Life Science and Genomics, Ruijin Hospital, Shanghai Jiaotong University, School of Medicine, Shanghai, China; Institute of Infectious and Respiratory Diseases, Ruijin Hospital, Shanghai Jiaotong University, School of Medicine, Shanghai, China; Department of Infectious Diseases, The Third Affiliated Hospital of Sun-Yat-Sen University, GuangZhou, - - 2014
We studied two patients from a nonconsanguineous family with life-long abnormal liver function, hepatomegaly and abnormal fatty acid profiles. Abnormal liver function, hypoglycemia and muscle weakness are observed in various genetic diseases, including medium-chain acyl-CoA dehydrogenase (MCAD) deficiency and glycogen storage diseases. The proband showed increased free fatty acids, mainly ...
Toubiana David D The Jacob Blaustein Institutes for Desert Research, Ben-Gurion University of the Negev, 84990, Midreshet Ben-Gurion, - - 2014
Correlation-based network analysis (CNA) of the metabolic profiles of seeds of a tomato Introgression Line mapping population revealed a clique of proteinogenic amino acids: Gly, Ile, Pro, Ser, Thr, and Val. Correlations between profiles of these amino acids exhibited a statistically significant average correlation coefficient of 0.84 as compared to ...
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