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Schwenk Daniel D Department of Pharmaceutical Microbiology at the Hans-Knöll-Institute, Friedrich-Schiller-Universität , Beutenbergstrasse 11a, 07745 Jena, - - 2014
A stereaceous basidiomycete was investigated with regard to its capacity to produce yellow pigments after physical injury of the mycelium. Two pigments were isolated from mycelial extracts, and their structures were elucidated by ESIMS and one- and two-dimensional NMR methods. The structures were identified as the previously undescribed polyenes (3Z,5E,7E,9E,11E,13Z,15E,17E)-18-methyl-19-oxoicosa-3,5,7,9,11,13,15,17-octaenoic ...
Burdge Graham C GC Academic Unit of Human Development and Health, Faculty of Medicine, University of Southampton, Southampton General Hospital, Southampton, - - 2015
The purpose of this article is to describe the structure, function and metabolism of fatty acids and lipids that are of particular importance in the context of parenteral nutrition. Lipids are a heterogeneous group of molecules that share the common property of hydrophobicity. Lipids range in structure from simple short ...
Demmelmair Hans H Division of Metabolic and Nutritional Medicine, Dr. von Hauner Children's Hospital, Ludwig-Maximilians-University of Munich, Munich, - - 2015
Long-chain polyunsaturated fatty acids (LC-PUFAs) influence a variety of cellular and physiological processes during the perinatal period by serving as membrane components, precursors of eicosanoids and docosanoids, and nuclear receptor activators. These processes include the growth of neural cells and signal transduction, the growth and differentiation of adipocytes, and the ...
Chiricozzi Elena E University of Milan, - - 2014
Lactosylceramide (LacCer) has been shown to contain very long fatty acids that specifically modulate neutrophil properties. The interactions between LacCer and proteins and their role in cell signalling processes were assessed by synthesizing two molecular species of azide-photoactivable, tritium labelled LacCer having acyl chains of different lengths. The lengths of ...
Cao Yi Y Department of Public Health, Section of Environmental Health, University of Copenhagen, Copenhagen, Denmark - - 2014
Fatty acids exposure may increase sensitivity of intestinal epithelial cells to cytotoxic effects of zinc oxide (ZnO) nanoparticles (NPs). This study evaluated the synergistic effects of ZnO NPs and palmitic acid (PA) or free fatty acids (FFAs) mixture (oleic/PA 2:1) on toxicity to human colon epithelial (Caco-2) cells. The ZnO ...
Hu Tingzhang - - 2014
Alpha linolenic acid and linoleic acid are essential fatty acids (EFAs) for humans and required for maintenance of optimal health, but they can not be synthesized by the human body and must be obtained from dietary sources. Using TomloxC fragment, TomloxD fragment and partial TomloxA sequence that is high identical ...
Fazili Naveed Ahmad NA Department of Biochemistry, Faculty of Life Science, Aligarh Muslim University, Aligarh 202 002, - - 2014
Alpha synuclein is a 14 kDa intrinsically disordered, presynaptic protein whose fibrillation is a critical step in the pathogenesis of Parkinson's disease (PD). A structural investigation of the effect of escitalopram (a selective serotonin reuptake inhibitor) on α-synuclein was performed using ANS and ThT assays, CD, Turbidity and Rayleigh scattering ...
Tu Guangwei G College of Pharmaceutical Sciences, Southwest University, 2 Tian Sheng Road, Beibei, Chongqing, 400715, People's Republic of - - 2014
The effect of Tween 80 on the fermentative production of polymalic acid (PMA) and pullulan using Aureobasidium pullulans CCTCC M2012223 was investigated. Tween 80 is beneficial for the biosynthesis of PMA and pullulan, and can regulate the ratio of PMA to pullulan in a dose-dependent manner. After adding 0.05 % Tween ...
Basak Sanjay S Department of Nutrition, Institute for Basic Medical Sciences, University of Oslo, POB 1046, Blindern, 0316, Oslo, Norway, - - 2014
The study aims to investigate the impacts of hyperglycemia in the presence of fatty acids on early placentation processes that involves tube formation, cellular growth and proliferation, and metabolic activities of the first trimester trophoblast cells. Effects of maternal circulatory glucose levels that mimic physiological (5.5 mM), pre-diabetic (11 mM) and diabetic ...
Matias de Oliveira Dyoni D Department of Biochemistry, Laboratory of Plant Biochemistry, State University of Maringá, Maringá, PR, - - 2014
In the near future, grasses must provide most of the biomass for the production of renewable fuels. However, grass cell walls are characterized by a large quantity of hydroxycinnamic acids such as ferulic and p-coumaric acids, which are thought to reduce the biomass saccharification. Ferulic acid (FA) binds to lignin, polysaccharides ...
Kwan Grace G Department of Plant Pathology, University of Wisconsin, - - 2014
Salmonella enterica is a member of the plant microbiome. Growth of S. enterica in sprouting seed exudates is rapid; however, the active metabolic networks essential in this environment are unknown. To examine the metabolic requirements of S. enterica during growth in sprouting seed exudates, we inoculated alfalfa seeds and identified ...
Liu Jie J State Key Laboratory of Natural Medicines, China Pharmaceutical University, 24 Tong Jia Xiang, Nanjing 210009, PR China; Department of Organic Chemistry, China Pharmaceutical University, 24 Tong Jia Xiang, Nanjing, 210009, PR - - 2014
Ambradiolic acid (3) with oleanane skeleton is a natural pentacyclictriterpene. The first synthesis of 3 starting from 23-hydroxybetulinic acid (2) has been accomplished in 12-steps with a total yield of 18.1% in our study. Compound 3 was further biologically evaluated and found to exhibit significant inhibitory activity against rabbit muscle ...
Isom Catherine E CE Department of Microbiology and Plant Biology, University of Oklahoma, Norman, OK, 73019, USA, - - 2014
"Clostridium ragsdalei" is an acetogen that ferments synthesis gas (syngas, predominantly H2:CO2:CO) to ethanol, acetate, and cell mass. Previous research showed that C. ragsdalei could also convert propionic acid to 1-propanol and butyric acid to 1-butanol at conversion efficiencies of 72.3 and 21.0 percent, respectively. Our research showed that C. ...
Qabaja Ghassan - - 2014
The kinetic resolution of hydroxy tert-butyl esters through a Brønsted acid catalyzed lactonization is described. The resulting enantioenriched molecules have cyclic backbones and/or multiple stereocenters. DFT calculations explore how small changes in substrate structure can have a large impact on the selectivity of the process.
Barnett Brandon R BR Department of Chemistry and Biochemistry, University of California, San Diego, 9500 Gilman Drive MC 0358, La Jolla, California 92093, USA. - - 2014
The activation of carbon dioxide, organonitriles, and terminal acetylenes by (boryl)iminomethanes derived from isocyanide 1,1-hydroboration is described. Also detailed is the generality of hydroboration of m-terphenylisocyanides with hydroboranes of differing Lewis acidities.
Dynkowska Wioletta M WM Department of Plant Biochemistry and Physiology, Plant Breeding and Acclimatization Institute -National Research Institute, Radzikow, PL-05-870, Blonie, - - 2014
Bread-making process influences bread components, including phenolics that significantly contribute to its antioxidant properties. Five bread model systems made from different rye cultivars were investigated to compare their impact on concentration of ethanol-soluble (free and ester-bound) and insoluble phenolics. Breads produced by a straight dough method without acid addition (A) ...
Szcześniak Piotr P Institute of Organic Chemistry, Polish Academy of Sciences , Kasprzaka 44/52, 01-224 Warsaw, - - 2014
A new strategy for stereoselective preparation of all four isomers of β- and γ-hydroxy α-amino acids is presented. The developed procedure is based on enzymatic kinetic resolution and cyanate-to-isocyanate rearrangement as key steps. Stereocontrol is achieved by proper choice of the starting hydroxyacid, the course of kinetic resolution, and the ...
García-González Iván I Departamento de Química, Centro de Investigación en Síntesis Química, Universidad de La Rioja, C/Madre de Dios 51, 26006 Logroño, La Rioja - - 2014
We synthesized and carried out the conformational analysis of several hybrid dipeptides consisting of an α-amino acid attached to a quaternary glyco-β-amino acid. In particular, we combined a S-glycosylated β(2,2) -amino acid and two different types of α-amino acid, namely, aliphatic (alanine) and aromatic (phenylalanine and tryptophan) in the sequence ...
Kataoka Hiroshi H Department of Pathology, UMass Medical School, Worcester, MA 01605, - - 2014
Necrotic cell death in vivo induces a robust neutrophilic inflammatory response and the resulting inflammation can cause further tissue damage and disease. Dying cells induce this inflammation by releasing pro-inflammatory intracellular components, one of which is uric acid. Cells contain high levels of intracellular uric acid, which is produced when ...
Lamminpää Kaisa K Chemical Process Engineering, University of Oulu, P.O. Box 4300 University of Oulu, FIN-90014, Finland. Electronic address: - - 2014
In this study, the effects of kraft lignin (Indulin AT) on acid-catalysed xylose dehydration into furfural were studied in formic and sulphuric acids. The study was done using D-optimal design. Three variables in both acids were included in the design: time (20-80min), temperature (160-180°C) and initial lignin concentration (0-20g/l). The ...
Bowler Jeannette T JT Department of Chemistry and Biochemistry, San Francisco State University, San Francisco, CA 94132 - - 2014
A convenient and efficient method for the synthesis of N1-substituted orotic acid derivatives is reported. The synthetic route utilizes substituted maleimide as synthetic intermediate and takes only four simple steps from readily available starting materials. As a result, orotic acid derivatives with various alkyl and aromatic groups at N1 can ...
Robinson Michelle D - - 2014
The functional properties of lipid-rich assemblies such as serum lipoproteins, cell membranes and intracellular lipid droplets are modulated by the fluidity of the hydrocarbon chain environment. Existing methods to monitor hydrocarbon chain fluidity include fluorescence, electron spin resonance and NMR spectroscopy; each possesses advantages and limitations. Here we introduce a ...
Dighe Shashikant Uttam - - 2014
An atom-economical regioselective synthesis of N-substituted prolinamides or N-substituted pirperidine-2-carboxamides via a metal-free decarboxylative multicomponent coupling between L-proline or pipecolic acid, aldehydes and isonitriles is described. The cascade event involves sequential imine formation, decarboxylation, isonitrile insertion and hydrolysis to afford the product in one-pot. Two of the prolinamides were found ...
Liu Zhenfeng Z School of Chemical Engineering and Energy, Zhengzhou University, Zhengzhou, 450001, China, - - 2014
The synthesis of D-isoascorbyl stearate from D-isoascorbic acid and stearic acid with immobilized lipase (Novozym(®)435) as catalyst was studied. Response surface methodology and Box-Behnken design with six variables and three levels were employed to evaluate the effects of processing conditions on the conversion of D-isoascorbic acid. The results confirmed that ...
Liu Pengzhan - - 2014
Leaves of bilberry (Vaccinium myrtillus L.) and lingonberry (Vaccinium vitis-idaea L.) are potential raw materials for food and health care products. Targeted (HPLC-DAD, HPLC-MS, and GC-FID) and non-targeted (1H NMR) approaches were applied to study the metabolomic profiles of these leaves. Chlorogenic acid was the major phenolic compound in bilberry ...
Honda Kaori L KL Cardiovascular Nutrition Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, 711 Washington Street, Boston, MA, 02111, USA, - - 2014
Dietary intake of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) and their respective enrichment in cell membranes have been negatively associated with atherosclerotic lesion development. This effect may be mediated, in part, by dampened inflammatory response of macrophages triggered by toll-like receptor 4 (TLR4) activation. This study investigated the influence ...
Sase Shohei S Department of Chemistry, Graduate School of Science and Engineering, Tokyo Institute of Technology, 2-12-1 Ookayama, Meguro-ku, Tokyo 152-8551 - - 2014
The unprecedented dehydration of a selenenic acid (RCH2 SeOH) to a selenoaldehyde (RCHSe) has been demonstrated. A primary-alkyl-substituted selenenic acid was synthesized for the first time by taking advantage of a bulky cavity-shaped substituent. Upon heating in solution, the selenenic acid underwent thermal dehydration to produce a stable selenoaldehyde, which ...
Ahmad Irshad I International Centre for Genetic Engineering and Biotechnology, New Delhi, - - 2014
Higher lipid biosynthesis and accumulation are important to achieve economic viability of biofuel production via microalgae. To enhance lipid content, Chlamydomonas reinhardtii was genetically engineered with a key enzyme diacylglycerol acyltransferase (BnDGAT2) from Brassica napus, responsible for neutral lipid biosynthesis. The transformed colonies harbouring aph7 gene, screened on hygromycin-supplemented medium, ...
Hsu Hsiu-Ching - - 2014
BackgroundUse of the chemotherapeutic drug doxorubicin (DOX) is associated with serious cardiotoxicity, as it increases levels of reactive oxygen species (ROS). N-3 polyunsaturated fatty acid dietary supplements can be of benefit to patients undergoing cancer therapy. The aims of this study were to determine whether DOX-induced cardiotoxicity is related to ...
Maruf Abdullah Al AA Graduate Department of Pharmaceutical Sciences, Leslie Dan Faculty of Pharmacy, University of Toronto, - - 2014
Glyoxal (GO) and methylglyoxal (MGO) cause protein and nucleic acid carbonylation and oxidative stress by forming reactive oxygen and carbonyl species which have been associated with toxic effects that may contribute to cardiovascular disease, complications associated with diabetes mellitus, Alzheimer's and Parkinson's disease. GO and MGO can be formed through ...
Deacon John J Department of Molecular Biophysics & Biochemistry, Yale University, New Haven, CT 06520, - - 2014
pHLIPs are a family of soluble ∼36 amino acid peptides, which bind to membrane surfaces. If the environment is acidic, a pHLIP folds and inserts across the membrane to form a stable transmembrane helix, thus preferentially locating itself in acidic tissues. Since tumors and other disease tissues are acidic, pHLIPs' ...
Habe Hiroshi H Research Institute for Innovation in Sustainable Chemistry, National Institute of Advanced Industrial Science and Technology (AIST), Tsukuba Central 5-2, 1-1-1 Higashi, Tsukuba, Ibaraki 305-8565, Japan. Electronic address: - - 2014
Levulinic acid (LA) is a platform chemical derived from cellulosic biomass, and the expansion of LA utilization as a feedstock is important for production of a wide variety of chemicals. To investigate the potential of LA as a substrate for microbial conversion to chemicals, we isolated and identified LA-utilizing bacteria. ...
Phan Stephanie S Monash Institute of Pharmaceutical Sciences, Monash University, 381 Royal Parade, Parkville, VIC 3052, - - 2014
During lipolysis of triglyceride by lipase, monoglyceride and fatty acids are produced which combine with gastrointestinal fluids to form self-assembled structures. These solubilize hydrophobic food components to promote their absorption. The aim of this study was a detailed understanding of structure formation from triglyceride digestion products with saturated short-, medium- ...
Hentrich Christian - - 2014
The earliest forms of cellular life would have required a membrane compartment capable of growth and division. Fatty acid vesicles are an attractive model of protocell membranes, as they can grow into filamentous vesicles that readily divide while retaining their contents. In order to study vesicle growth we have developed ...
Kovalenko Vitaly N VN Department of Organic Chemistry, Belarusian State University, Minsk, - - 2014
Separation of optical isomers obtainable from trans-norborn-5-ene-2,3-dicarboxylic acid methyl and tert-butyl monoesters was performed by crystallization of the respective salts prepared with (R)- and (S)-1-phenylethylamine. Starting from racemic endo-monomethyl ester of trans-norborn-5-ene-2,3-dicarboxylic acid, prepared by partial hydrolysis of the cyclopentadiene-dimethyl fumarate adduct, the corresponding (2R,3R)-endo-monoester was isolated in 97% enantiomeric ...
Kawahara-Kobayashi Akio A Department of Computational Intelligence and Systems Science, Interdisciplinary Graduate School of Science and Engineering, Tokyo Institute of Technology, Yokohama, Kanagawa, 226-8503, - - 2014
At some stage of evolution, genes of organisms may have encoded proteins that were synthesized using fewer than 20 unique amino acids. Similar to evolution of the natural 19-amino-acid proteins GroEL/ES, proteins composed of 19 unique amino acids would have been able to evolve by accumulating beneficial mutations within the ...
Hong Yun-Jin YJ Department of Food Bioscience and Technology, College of Life Sciences and Biotechnology, Korea - - 2014
2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) is formed as a by-product of the Maillard reaction during cooking and frying of protein-rich foods at high temperatures. PhIP is metabolized in the liver by cytochrome P450 1A1/2 to carcinogenic metabolite N-hydroxy PhIP, which can form DNA adduct. The ABC transporters, P-glycoprotein (P-gp), multidrug resistance-associated protein 2 (MRP2) ...
Zakaria Mohd Rafein MR Biomass Refinery Research Center, National Institute of Advanced Industrial Science and Technology (AIST), 3-11-32 Kagamiyama, Higashi-Hiroshima, Hiroshima 739-0046, Japan; Department of Bioprocess Technology, Faculty of Biotechnology and Biomolecular Sciences, Universiti Putra Malaysia, 43400 UPM Serdang, Selangor, Malaysia. Electronic address: - - 2014
The present works investigate hydrothermal pretreatment of oil palm empty fruit bunch and oil palm frond fiber in a batch tube reactor system with temperature and time range from 170 to 250°C and 10 to 20min, respectively. The behavior of soluble sugars, acids, furans, and phenols dramatically changed over treatment ...
Li Jing J State Key Laboratory of Food Science and Technology, Synergetic Innovation Center of Food Safety and Nutrition, School of Food Science and Technology, Jiangnan University, Wuxi 214122, - - 2014
Glucose and glycerol are useful carbon sources for the cultivation of Aurantiochytrium limacinum SR21. Glucose facilitates rapid growth and lipid synthesis, and glycerol promotes the accumulation of docosahexaenoic acid (DHA) in A. limacinum SR21. To improve the DHA productivity of A. limacinum SR21, shake flask and fed-batch cultures were performed ...
Rezanka Tomáš T Institute of Microbiology, Academy of Sciences of the Czech Republic, Vídeňská 1083, 142 20, Prague, Czech Republic, - - 2014
The methods of preparation of fatty acids from brewer's yeast and its use in production of biofuels and in different branches of industry are described. Isolation of fatty acids from cell lipids includes cell disintegration (e.g., with liquid nitrogen, KOH, NaOH, petroleum ether, nitrogenous basic compounds, etc.) and subsequent processing ...
Schmidt Monica A MA School of Plant Sciences/BIO5 Institute, University of Arizona, Tucson, AZ, - - 2014
Transgenic soya bean (Glycine max) plants overexpressing a seed-specific bacterial phytoene synthase gene from Pantoea ananatis modified to target to plastids accumulated 845 μg β carotene g(-1) dry seed weight with a desirable 12:1 ratio of β to α. The β carotene accumulating seeds exhibited a shift in oil composition increasing ...
Bailey T Spencer TS Department of Chemistry and Biochemistry, Institute of Molecular Biology, Materials Science Institute, University of Oregon, Eugene, OR 97403, USA. - - 2014
d-Amino acid oxidase (DAO) plays important roles in regulating d-amino acid neurotransmitters and was recently identified as a key enzyme integral to hydrogen sulfide production from d-Cys. We report here the development of a simple biocompatible, bioluminescent method for measuring DAO activity based on the highly selective condensation of d-Cys ...
Chung Seung Won SW Department of Otorhinolaryngology-Head and Neck Surgery, Korea University College of Medicine, Seoul, - - 2014
Caffeic acids are known to have anti-oxidant, anti-inflammatory, immunomodulatory, and tissue reparative effects. The purposes of this study were to determine the effect of caffeic acid on transforming growth factor (TGF) β1-induced myofibroblast differentiation and collagen production, and to determine whether caffeic acid is involved in the antioxidant effect in ...
T Chitranjali C Department of Biochemistry, University of Kerala , Thiruvananthapuram, Kerala , India - - 2014
Abstract The health benefits of omega-3 polyunsaturated fatty acids (ω-3 PUFA), mainly eicosapentaenoic acid (EPA 20:5) and docosahexaenoic acid (DHA, 22:6), have been long known. Although various studies have demonstrated the health benefits of ω-3 PUFA, the mechanisms of action of ω-3 PUFAs are still not completely understood. While the ...
Xue Pengchong P State Key Laboratory of Supramolecular, Structure and Materials, College of Chemistry, Jilin University, No. 2699 Qianjin Street, Changchun (China). - - 2014
Two L-phenylalanine derivatives with 5,8-bis(2-(carbazol-3-yl)vinyl)quinoxaline (PCQ) and 5,8-bis[2-(carbazol-3-yl)]-2,3-dimethylquinoxaline (DCQ) as fluorophores were synthesized, and their photophysical properties were measured and compared. The two compounds were found to gelate some organic solvents and self-assemble into 1D nanofibers in gels. The wet gel of PCQ emitted a weak orange fluorescence, but the ...
Tsuchiya Ayako A Division of Bioinformation, Department of Physiology, Institute for Advanced Medical Sciences, Hyogo College of Medicine, - - 2014
The present study investigated cis-unsaturated free fatty acid (FFA)-regulated glucose uptake. In the cell-free assay of protein tyrosine phosphatase 1B (PTP1B), cis-unsaturated FFAs such as linoleic, linolenic, and oleic acid significantly suppressed PTP1B activity in a concentration (1 - 100 μM)-dependent manner, with the highest potential for oleic acid. Oleic ...
Baarine Mauhamad M Department of Pediatrics, Darby Children's Research Institute, Medical University of South Carolina, 29425, Charleston, - - 2014
X-linked Adrenoleukodystrophy (X-ALD), an inherited peroxisomal metabolic neurodegenerative disorder, is caused by mutations/deletions in the ABCD1 gene encoding peroxisomal ABC transporter adrenoleukodystrophy protein (ALDP). Metabolic dysfunction in X-ALD is characterized by the accumulation of very long chain fatty acids (VLCFAs; ≥ C22:0) in the tissues and plasma of patients. Here, ...
Gong Jinyan J 1 Zhejiang Provincial Key Lab for Chem & Bio Processing Technology of Farm Produces, School of Biological and Chemical Engineering, Zhejiang University of Science and Technology , Hangzhou, People's Republic of China - - 2014
Abstract This study was designed to detect characteristic compounds and evaluate the free radical scavenging capacity of the bamboo leaves extract and bamboo shavings extract (BSE). The antioxidant capacity of bamboo leaf n-butanol fraction (AOB) exhibited the highest total phenolic content (49.93%), total flavonoids content (24.11%), and characteristic flavonoids and ...
Zhou Ying Y Department of Cardiology, Key Laboratory on Assisted Circulation, First Affiliated Hospital, Sun Yat‑sen University, Guangzhou, Guangdong 510080, P.R. - - 2014
As a daily supplement, omega‑3 fatty acid is confirmed to be of benefit in hypertriglyceridemia. However, the effect of omega‑3 fatty acids on the low‑density lipoprotein cholesterol (LDL‑C) metabolism remains a controversial issue. In this study, we focused on the regulatory effect of docosahexanoic acid (DHA), one type of omega‑3 ...
Fuentes Eduardo E Faculty of Health Sciences, Department of Clinical Biochemistry and Immunohaematology, Interdisciplinary Excellence Research Program on Healthy Aging (PIEI-ES), Universidad de Talca, Talca, Chile; Centro de Estudios en Alimentos Procesados (CEAP), CONICYT-Regional, Gore Maule R09I2001, Chile. Electronic address: - - 2014
An endothelial dysfunction generates a proatherogenic environment characterized by stimulating thrombus formation. Epidemiological studies have provided evidence of a protective role of healthy diets in the prevention of cardiovascular diseases. Hydroxycinnamic acids constitute abundant polyphenols in our diets as they are present in high levels in many widely consumed foods, ...
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