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Dansey Maria Virginia - - 2014
Dafachronic acids (DAs) are 3-keto colestenoic acids bearing a carboxylic acid moiety at the end of the steroid side chain. These compounds interact with the DAF-12 receptor, a ligand dependent transcription factor that acts as a molecular switch mediating the choice between arrest at diapause or progression to reproductive development ...
Lemaitre Rozenn N RN University of Washington, United States; - - 2014
Very long-chain saturated fatty acids (VLSFA) are saturated fatty acids with 20 or more carbons. In contrast to the more abundant saturated fatty acids, such as palmitic acid, there is growing evidence that circulating VLSFA may have beneficial biological properties. Whether genetic factors influence circulating levels of VLSFA is not ...
Wagner Carsten A CA Institute of Physiology, University of Zurich, Zurich, - - 2014
Aldosterone is classically associated with the regulation of salt and potassium homeostasis but has also profound effects on acid-base balance. During acidosis, circulating aldosterone levels are increased and the hormone acts in concert with angiotensin II and other factors to stimulate renal acid excretion. Pharmacological blockade of aldosterone action as ...
Lamounier-Zepter V V Clinical Medicine III, Dresden University of Technology, Dresden, - - 2014
Background:Adipocyte fatty acid-binding protein (FABP4) is a member of a highly conserved family of cytosolic proteins that bind with high affinity to hydrophobic ligands such as saturated and unsaturated long-chain fatty acids and eicosanoids. Recent evidence has supported a novel role for FABP4 in linking obesity with metabolic and cardiovascular ...
Acharyya Koushik K Department of Inorganic and Physical Chemistry, Indian Institute of Science, Bangalore 560012, India. - - 2014
Dynamic covalent imine chemistry has been utilized to synthesize a fluorescent [3+2] self-assembled nanoscopic organic cage. The fluorescent nature of the reduced analogue of the cage was further exploited for the highly selective detection of the explosive picric acid (PA).
Kumar N Mithil NM a Composites Research Group , Department of Mechanical - - 2014
ABSTRACT Polyaspartic acid (PSI) is suitable for the inhibition of inorganic scale deposition. To enhance its scale inhibition efficiency, PSI was modified by reacting aspartic acid (ASP) with malic acid (MA) using thermal polycondensation polymerization. This reaction resulted in poly (aspartic acid-co-malic acid) (PSI-co-MA) dual polymer. The structural, chemical and ...
Bai Yunpeng - - 2014
This study determined the fate of deoxyanthocyanidins in sorghum sourdoughs. Sourdoughs prepared from the red sorghum variety Town was fermented with the caffeic acid- decarboxylating strains Lactobacillus plantarum FUA3171 and the decarboxylase negative L. casei FUA3166. Deoxyanthocyanidins were analysed by LC-MS/MS. Apigeninidin and methoxyapigeninidin were the major deoxyanthocyanidins prior to ...
Toops Kimberly A KA Department of Ophthalmology and Visual Sciences, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI, USA McPherson Eye Research Institute, University of Wisconsin-Madison, Madison, WI, - - 2014
Autophagy is an essential mechanism for clearing damaged organelles and proteins within the cell. As with neurodegenerative diseases, dysfunctional autophagy could contribute to blinding diseases like macular degeneration. However, precisely how inefficient autophagy promotes retinal damage is unclear. Here, we investigate innate mechanisms that modulate autophagy in the retinal pigment ...
Gomez-Hernandez Mario - - 2014
The heterogeneous chemistry of glyoxal on sulfuric acid surfaces has been investigated at various acid concentrations and temperatures, utilizing a low-pressure fast flow laminar reactor coupled to an ion drift - chemical ionization mass spectrometer (ID-CIMS). The uptake coefficient (γ) of glyoxal ranges from (1.2 ± 0.06) x 10-2 to ...
Rigano Maria Manuela - - 2014
Solanum lycopersicum represents an important source of antioxidants and other bioactive compounds. We previously identified two Solanum pennellii introgression lines (IL 7-3 and IL 12-4) carrying Quantitative Trait Loci (QTL) increasing fruit ascorbic acid and phenolics content. Novel tomato lines were obtained by pyramiding these selected QTLs in the genetic ...
Carpy Alejandro A University of Tuebingen, - - 2014
Stable Isotope Labeling by Amino Acids (SILAC) is a commonly used method in quantitative proteomics. Due to compatibility with trypsin digestion, arginine and lysine are the most widely used amino acids for SILAC labeling. We observed that Schizosaccharomyces pombe (fission yeast) cannot be labeled with a specific form of arginine, ...
Rünzi Thomas T Chair of Chemical Materials Science, Department of Chemistry, University of Konstanz, Universitätsstrasse 10, 78457, Konstanz, - - 2014
Insertion of diethyl vinyl phosphonates and free vinyl phosphonic acid, respectively, into [(P^O)Pd(Me)(dmso)] ((P^O) =κ(2) -P,O-Ar2 PC6 H4 SO2 O with Ar = 2-MeOC6 H4 ) (1-dmso) occurs in a 2,1- as well as 1,2-fashion, to form a four-and a five-membered chelate [(P^O)Pd{κ(2) -C,O-CH(P(O)(OR)2 )CH2 CH3 }] and [(P^O)Pd{κ(2) -C,O-CH2 ...
Moukha-Chafiq Omar O a Southern Research Institute , Drug Discovery Division , Birmingham , Alabama , - - 2014
A small library of fifty-five adenosine peptide analogs was synthesized, under the Pilot Scale Library (PSL) Program of the NIH Roadmap initiative, from 2',3'-O-isopropylideneadenosine-5'-carboxylic acid 2. The coupling of amine or sulfanilamide reactants to the free 5'-carboxylic acid moiety of 2, in automated solution-phase fashion, led after acid-mediated hydrolysis to ...
Malkar Vishwabharati V VV Radiation & Photochemistry Division, Bhabha Atomic Research Centre, Trombay, Mumbai 400 085, - - 2014
Formation of silver nanoparticles in the presence of various aminipolycarboxylic acids (APCAs) such as iminodiacetic acid (IDA), nitrilotriacetic acid (NTA), ethylenediaminetetraacetic acid (EDTA), N-(2-hydroxyethyl) ethylenediaminetriacetic acid (HEDTA), diethylenetriaminepentaacetic acid (DTPA), and N,N,N',N″,N‴,N‴-triethylenetetraminehexaacetic acid (TTHA) was studied. Monodispersed silver nanoparticles capped by carboxylate groups of APCAs were prepared by the reduction ...
Wang Yaxing - - 2014
BackgroundRecent efforts demonstrated the potential application of cyanobacteria as a ¿microbial cell factory¿ to produce butanol directly from CO2. However, cyanobacteria have very low tolerance to the toxic butanol, which limits the economic viability of this renewable system.ResultsThrough a long-term experimental evolution process, we achieved a 150% increase of the ...
Lee Ju Young JY Biomaterials Laboratory, Samsung Advanced Institute of Technology, Gyeonggi-do, - - 2014
Owing to the growing market for the biodegradable and renewable polymer, polylactic acid, world demand for lactic acid is rapidly increasing. However, the very high concentrations desired for industrial production of the free lactic acid create toxicity and low pH concerns for manufacturers. Saccharomyces cerevisiae is the most well characterized ...
Ioroi Tadaaki T Department of Pharmacology, Graduate School of Pharmaceutical Sciences, Kyoto University, - - 2014
We previously reported that serofendic acid, a lipophilic extract of fetal calf serum, protects against oxidative stress in primary culture of neonatal rat cardiomyocytes. However, the effect of serofendic acid on myocardial ischemia-reperfusion injury in vivo is yet to be determined. In the present study, we investigated the effect of ...
Zhou Zhifang Z Department of Chemistry, Wayne State University, Detroit, Michigan 48202, - - 2014
A convenient method was developed for the quantification of sialic acids expressed by cells and used to analyze the efficiency of N-phenylacetyl-D-mannosamine (ManNPhAc) to metabolically glycoengineer SKMEL-28 cancer cell. For this purpose, ManNPhAc-cultured cells were treated with 2M acetic acid to release sialic acids, and the products were treated with ...
Shichiri Mototada M Health Research Institute (HRI), National Institute of Advanced Industrial Science and Technology (AIST), 2217-14 Hayashi-cho, Takamatsu, Kagawa 761-0395, - - 2014
An increase in the proportion of fatty acids with higher numbers of double bonds is believed to increase lipid peroxidation, which augments the risk for many chronic diseases. (n-3) Polyunsaturated fatty acids provide various health benefits, but there is a concern that they might increase lipid peroxidation. We examined the ...
You Xun - - 2014
A lead(IV) acetate-promoted radical reaction of [60]fullerene with halocarboxylic acids has been exploited to synthesize the rare ortho acid ester-type 1,3-dioxolanofullerenes, of which the hydroxyl group can be further transformed to an ester or ether group. Intriguingly, an ortho acid ester-type 1,3-dioxolanofullerene can also be converted to a 1,4-dioxolanonofullerene in ...
Toubiana David D The Jacob Blaustein Institutes for Desert Research, Ben-Gurion University of the Negev, 84990, Midreshet Ben-Gurion, - - 2014
Correlation-based network analysis (CNA) of the metabolic profiles of seeds of a tomato Introgression Line mapping population revealed a clique of proteinogenic amino acids: Gly, Ile, Pro, Ser, Thr, and Val. Correlations between profiles of these amino acids exhibited a statistically significant average correlation coefficient of 0.84 as compared to ...
Yuan Ming-Ming MM a Jiangxi Provincial Institute for Drug and Food Control , Nanchang 330029 , - - 2014
Two new triterpenoids, 2α,3β,16α,19α,23-pentahydroxyolean-12-en-28-oic acid (1) and 2α,3α,11α,21α,23-pentahydroxyurs-12-en-28-oic acid (2), were isolated from the aerial parts of Callicarpa kwangtungensis. Their structures were elucidated by 1D and 2D analyses, as well as MS and IR spectra.
Wang Fen F State Key Laboratory of Fine Chemicals, Dalian University of Technology, Dalian, 116024, P. R. China. - - 2014
Acid-switching of the triplet excited state in rhodamine-C60 dyads was achieved. The rhodamine moiety acts as an acid-activated visible light-harvesting antenna and C60 as the singlet energy acceptor and the spin converter, and production of the triplet state was enhanced in the presence of acid.
Li Ruimin - - 2014
An efficient and facile synthesis method of nitrogen-doped mesoporous graphitic carbon (NMGC) was reported with melamine as a nitrogen source and citric acid as a carbon source. By taking advantage of the functional groups on melamine and citric acid, a uniform mixture of these two components was obtained via a ...
Matsumoto Naoki N Tokyo Noko University, - - 2014
Although ischemic stroke is a major cause of death and disability worldwide, only a small fraction of patients benefits from the current thrombolytic therapy due to a risk of cerebral hemorrhage caused by inflammation. Thus, the development of a new strategy to combat inflammation during thrombolysis is an urgent demand. ...
Song Yifan Y http://orcid.org/0000-0001-8064-3564 Cyrus Biotechnology, Inc., Seattle, WA 98101; - - 2014
Key mutations differentiate the functions of homologous proteins. One example compares the inward ion pump halorhodopsin (HR) and the outward proton pump bacteriorhodopsin (BR). Of the nine essential buried ionizable residues in BR, six are conserved in HR. However, HR changes three BR acids, D85 in a central cluster of ...
Yip Wai Lam WL School of Pharmacy, Department of Pharmacy, University of Oslo, P.O. Box 1068 Blindern, 0316, Oslo, Norway, - - 2014
The aim of current study was to investigate the influence of a common non-ionic surfactant, polysorbate 80 (PS80), on radioactive labelling process of a novel PET tracer, [(18)F]Flutemetamol. Ferrous oxidation-xylenol orange (FOX) assay, in addition to UV/VIS and (1)H NMR spectroscopies were applied to characterise the composition of the PS80 ...
Koynova Rumiana R Ohio State University College of Pharmacy 517 Parks Hall, 500 W 12th Ave Columbus, OH 43210, USA. - - 2014
The development of nucleic acid-based drugs has attracted considerable interest in the past two decades as a new category of biologics. A key challenge in successfully achieving the full potential of nucleotide therapeutics is their efficient delivery. Synthetic cationic lipids are currently the most extensively used non-viral nucleotide carriers because ...
Mooranian Armin A Biotechnology and Drug Development Research Laboratory, School of Pharmacy, Curtin Health Innovation Research Institute, Biosciences Research Precinct, Curtin University , Perth, Western Australia , - - 2014
This study utilized the Seahorse Analyzer to examine the effect of the bile acid ursodeoxycholic acid (UDCA), on the morphology, swelling, stability, and size of novel microencapsulated β-cells, in real-time. UDCA was conjugated with fluorescent compounds, and its partitioning within the microcapsules was examined using confocal microscopy. UDCA produced microcapsules ...
Cao H L HL Key Laboratory for Ultrafine Materials of Ministry of Education, and Shanghai Key Laboratory of Advanced Polymeric Materials, School of Materials Science and Engineering, East China University of Science and Technology, Shanghai 200237, China. - - 2014
An acid labile branched PDMAEMA/acetal copolymer with amino group was synthesized by the DE-ATRP and followed by Michael addition. The degradation of the polymer was strongly pH-dependent. High nucleic acid transfection efficiency with low cytotoxicity was observed compared to its non-degradable copolymer counterpart.
Varlamov Oleg O Division of Diabetes, Obesity, and Metabolism and Developmental and Reproductive Science (O.V., C.T.R.), Division of Neuroscience (A.C.), Department of Medicine, Oregon National Primate Research Center, Beaverton, Oregon 97006; and Division of Endocrinology, Diabetes, and Clinical Nutrition (M.C., C.T.R.) and Center for Research on Environmental and Occupational Technology (H.S.), Oregon Health and Science University, Portland, Oregon - - 2014
Phenotypic diversity may play an adaptive role by providing graded biological responses to fluctuations in environmental stimuli. We used single-cell imaging, using the metabolizable fluorescent fatty acid analog 4,4-difluoro-4-bora-3a,4a-diaza-s-indacene (BODIPY)-C12 and fluorescent 2-[N-(7-nitrobenz-2-oxa-1,3-diazol-4-yl) amino]-2-deoxy-D-glucose, to explore cellular heterogeneity in nutrient uptake in white adipose tissue (WAT) explants of rhesus macaques. ...
Fritz Georg G LOEWE Center for Synthetic Microbiology, Philipps-University Marburg, 35043 Marburg, - - 2014
Bacterial cell wall homeostasis is an intricately coordinated process that ensures that envelope integrity is maintained during cell growth and division, but can also adequately respond to growth-limiting conditions such as phosphate starvation. In Bacillus subtilis, biosynthesis of the two major cell wall components, peptidoglycan and anionic polymers, is controlled ...
Buhrke Thorsten T Department of Food Safety, Federal Institute for Risk Assessment, Max-Dohrn-Str. 8-10, 10589, Berlin, Germany, - - 2014
The food contaminants 3-chloro-1,2-propanediol (3-MCPD) and 3-MCPD fatty acid esters have attracted considerable attention in the past few years due to their toxic properties and their occurrence in numerous foods. Recently, significant amounts of the isomeric compounds 2-chloro-1,3-propanediol (2-MCPD) fatty acid esters have been detected in refined oils. Beside the ...
Armstrong Alissa R AR Department of Biochemistry and Molecular Biology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD 21205, USA Division of Reproductive Biology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD 21205, - - 2014
How adipocytes contribute to the physiological control of stem cells is a critical question towards understanding the link between obesity and multiple diseases, including cancers. Previous studies have revealed that adult stem cells are influenced by whole-body physiology through multiple diet-dependent factors. For example, nutrient-dependent pathways acting within the Drosophila ...
Dato Laura - - 2014
BackgroundThe great interest in the production of highly pure lactic acid enantiomers comes from the application of polylactic acid (PLA) for the production of biodegradable plastics. Yeasts can be considered as alternative cell factories to lactic acid bacteria for lactic acid production, despite not being natural producers, since they can ...
Zacherl Janelle R JR Department of Pathology, University of Pittsburgh, Pittsburgh, PA, - - 2014
Artificial trans fatty acids promote atherosclerosis by blocking macrophage clearance of cell debris. Classical fatty-acid response mechanisms include TLR4-NF-κB activation, and Erk1/2 phosphorylation, but these may not indicate long-term mechanisms. Indeed, nuclear NF-κB was increased by 60 min treatment by 30 μM of the 18 carbon trans unsaturated fatty acid elaidic acid ...
Malik Abaid A Department of Physiology, University of Tuebingen, - - 2014
Background/Aims: Aristolochic Acid, a component of Aristolochia plants, has been shown to cause acute kidney injury, renal aristolochic acid nephropathy, Balkan endemic nephropathy, and urothelial carcinoma. Aristolochic acid nephropathy may be associated with severe anemia. The anemia could theoretically be due to stimulation of eryptosis, the suicidal death of erythrocytes ...
Zhang Lizhi L School of Biological Sciences, Center for Reproductive Biology, Washington State University, Pullman, WA, 99164, - - 2014
The development of sink organs such as fruits and seeds strongly depends on the amount of nitrogen that is moved within the phloem from photosynthetic active source leaves to the reproductive sinks. In many plant species nitrogen is transported as amino acids. In pea (Pisum sativum L.) source to sink ...
Milecka Dorota D Department of Applied Microbiology, Faculty of Biology, University of Warsaw, Miecznikowa 1, 02-096, Warsaw, - - 2014
The expression of ten genes of Listeria monocytogenes previously identified as penicillin G-inducible was transcriptionally analyzed in the presence of 0.5 M KCl, pH 5.0 and 42 °C. This study revealed that all the genes are upregulated by osmotic stress, seven by acid stress and four by temperature stress conditions. The contribution ...
Hou Yucui - - 2014
Due to the similar properties and very low volatility, isomers of benzene polycarboxylic acids (BPCAs) are very difficult to separate. In this work, we found that isomers of BPCAs could be separated efficiently by quaternary ammonium salts (QASs) via forming deep eutectic solvents (DESs). Three kinds of QASs were used ...
Askari M M Department of Maxillofacial Pathology, Faculty of Dentistry, International Campus, Tehran University of Medical Sciences, Tehran, - - 2014
Oral squamous cell carcinoma (OSCC) is a remarkable health problem worldwide, but its pathogenesis remains unknown. The aim of this study was to compare fat composition and secretory phospholipase-A2 (sPLA2) activity between the malignant and adjacent normal squamous tissues in patients with OSCC. Paired samples of malignant squamous and adjacent ...
Ueda Minoru M Laboratory of Organic Chemistry, Department of Chemistry, Tohoku University, 6-3 Aramaki-Aza Aoba, Aoba-ku, Sendai 980-8578, Japan. - - 2014
12-O-β-d-Glucopyranosyljasmonic acid (JAG, ) induces nyctinastic leaf-folding of Samanea saman. The SAR studies of revealed the unique role of its glycone moiety. Biological activity and the target affinity of were affected by the stereochemistry of the glycone moiety. JAG belongs to a unique class of ligands in which the structure ...
Jiang Nan N State Key Laboratory of Advanced Technology for Materials Synthesis and Processing, and School of Materials Science and Engineering, Wuhan University of Technology, Wuhan, 430070, China. xyyang@whut.edu.cn tian.ge@yahoo.com - - 2014
Amino acid-based biohybrids have been developed to self-assemble on the surface of desulfurizing bacteria to form nanothin and nanoporous shells. The shells not only endow the encapsulated cells with reusability, but also offer platforms to incorporate titania and magnetic nanoparticles to improve the desulfurizing activity and the separation efficiency.
Chalmers Benjamin A BA Faculty of Science and Engineering, Queensland University of Technology , P.O. Box 2434, 2 George Street, Brisbane, QLD 4001, - - 2014
We report the synthesis of a new class of molecules which are hybrids of long-lived tetramethylisoindolinoxyl (TMIO) radicals and the pyrido[1,2-a]benzimidazole (PyrImid) scaffold. These compounds represent a new lead for noncovalently binding nucleic acid probes, as they interact with nucleic acids with previously unreported C (DNA) and C/U (RNA) complementarity, ...
Yan Ziru Z School of Medicine, Zhejiang University, Hangzhou, - - 2014
The aim of this study was to investigate the transport of two kinds of bile acids by organic anion transporting polypeptide 1B3 (OATP1B3) using first-trimester trophoblasts. The mechanisms of damage to fetuses with intrahepatic cholestasis of pregnancy were investigated, providing new potential strategies for targeted therapies aimed at reducing fetal ...
Zanato Chiara C Kosterlitz Centre for Therapeutics, Institute of Medical Sciences, University of Aberdeen, Foresterhill, AB25 2ZD, Scotland, UK. - - 2014
(-)-Kainic acid potently increases stretch-induced afferent firing in muscle spindles, probably acting through a hitherto uncloned phospholipase D (PLD)-coupled mGlu receptor. Structural modification of (-)-kainic acid was undertaken to explore the C-4 substituent effect on the pharmacology related to muscle spindle firing. Three analogues were synthesised by highly stereoselective additions ...
Agasti Soumitra S Department of Chemistry, Indian Institute of Technology Bombay, Powai, Mumbai-400076, India. - - 2014
A palladium catalyzed intermolecular annulation of cinnamic acids and phenols has been achieved for the selective synthesis of 3-substituted benzofurans. Isotope labeling, competition experiments, kinetic studies, and intermediate trapping have supported a sequence of C-C bond formation and decarboxylation followed by the C-O cyclization pathway.
Li Jie - - 2014
CuInS2 nanorods and networks are interesting candidates for applications requiring efficient charge transport, such as, solar energy conversion, because of the increased electrical conductivity in elongated or interconnected nanocrystals, compared to isolated, quasi-spherical ones. However, little is known about the growth mechanisms involved in the formation of this kind of ...
Myeong Jongyun J Seoul National University College of Medicine, Korea, Republic - - 2014
Canonical transient receptor potential (TRPC) channels are Ca(2+)-permeable nonselective cation channels that are activated by a wide variety of stimuli, including G protein-coupled receptors (GPCRs). The TRPC4 channel is expressed in a punctate distribution in the membrane. To identify the regulating region of the channel trafficking to the membrane, we ...
Brett Katharina K Free University Berlin, - - 2014
S-acylation of hemagglutinin (HA), the main glycoprotein of Influenza viruses, is an essential modification required for virus replication. Using mass spectrometry we have previously demonstrated specific attachment of acyl chains to individual acylation sites. Whereas the two cysteines in the cytoplasmic tail of HA contain only palmitate, stearate is exclusively ...
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