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Wang Xiao-Yin XY State Key Laboratory of Drug Research, CAS Key Laboratory of Receptor Research, the National Center for Drug Screening, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, - - 2014
Aim:TGR5 is a G protein-coupled receptor that is expressed in intestinal L-cells and stimulates glucagon-like peptide 1 (GLP-1) secretion. TGR5 may represent a novel target for the treatment of metabolic disorder. Here, we sought to design and synthesize a series of TGR5 agonists derived from the natural product betulinic acid.Methods:A ...
Zhang Yan-Ru YR Institute of Organic Chemistry, School of Chemistry and Chemical Engineering, Shandong University, Jinan 250100, P. R. China. - - 2014
We developed a ratiometric fluorescent probe for sensing HOCl based on coumarin and rhodamine acid that is directly used as a detection moiety. The probe shows high selectivity and sensitivity toward HOCl under best working conditions of myeloperoxidase by which HOCl can be generated from hydrogen peroxide and chloride.
Ogunleye Adetoro A Faculty of Science and Engineering, University of Wolverhampton, UK; - - 2014
Poly-gamma-glutamic acid (gamma-PGA) is a naturally occurring biopolymer made up of repeating units of L-glutamic acid, D-glutamic acid or both. gamma-PGA can exhibit different properties (conformational states, enantiomeric properties and molecular weight). Owing to its biodegradable, non-toxic and non-immunogenic properties, it has been successfully used in the food, medical and ...
Hsiao Chien-Chi CC Institute of Organic Chemistry, RWTH Aachen University, Landoltweg 1, 52074 Aachen - - 2014
A protocol for the highly enantioselective synthesis of 9-substituted tetrahydroxanthenones by means of asymmetric Brønsted acid catalysis has been developed. A chiral binol-based N-triflyphosphoramide was found to promote the in situ generation of ortho-quinone methides and their subsequent reaction with 1,3-cyclohexanedione to provide the desired products with excellent enantioselectivities. In ...
Zhang Yuheng Y Key Laboratory of Green Chemistry and Technology, Ministry of Education, College of Chemistry, Sichuan University, Chengdu 610064 (P.R. China), Fax: - - 2014
A simple and efficient acylative kinetic resolution of racemic mandelic acid esters was accomplished with a chiral N,N'-dioxide-scandium(III) complex under mild and base-free reaction conditions. A variety of mandelic acid esters performed well in the reaction, obtaining both acylated products (up to 49% yield, 97% ee) and recovered substrates (up ...
Andrisic Luka L Rudjer Boskovic Institute, Bijenicka 54, 10000, Zagreb, - - 2014
Pathophysiology of polyunsaturated fatty acids (PUFAs) is associated with aberrant lipid and oxygen metabolism. In particular, under oxidative stress, PUFAs are prone to autocatalytic degradation via peroxidation, leading to formation of reactive aldehydes with numerous potentially harmful effects. However, the pathological and compensatory mechanisms induced by lipid peroxidation are very ...
Oliva Moran M Department of Ornamental Horticulture, Agriculture Research Organization, The Volcani Center, Beit Dagan, Israel; Department of Plant Sciences, The Weizmann Institute of Science, Rehovot, - - 2014
Purple Petunia × hybrida V26 plants accumulate fragrant benzenoid-phenylpropanoid molecules and anthocyanin pigments in their petals. These specialized metabolites are synthesized mainly from the aromatic amino acids phenylalanine. Here, we studied the profile of secondary metabolites of petunia plants, expressing a feedback-insensitive bacterial form of 3-deoxy-di-arabino-heptulosonate 7-phosphate synthase enzyme (AroG*) of the ...
Mozziconacci Olivier - - 2014
The photo-irradiation of a monoclonal antibody 1 (mAb1) at lambda = 254 nm and lambdamax = 305 nm resulted in the sequence-specific generation of D-Val, D-Tyr, and potentially D-Ala and D-Arg, in the heavy chain sequence [95-101] YCARVVY. D-amino acid formation is most likely the product of reversible intermediary carbon-centered ...
Yan Shifeng - - 2014
Injectable hydrogels as an important biomaterial class have been widely used in regenerative medicine. A series of injectable poly(L-glutamic acid)/alginate (PLGA/ALG) hydrogels were fabricated by self-crosslinking of hydrazide-modified poly(L-glutamic acid) (PLGA-ADH) and aldehyde-modified alginate (ALG-CHO). Both the degree of PLGA modification and the oxidation degree of ALG-CHO could be adjusted ...
Xu Li - - 2014
A series of new amino-functionalized tetraphenylethene (TPE) derivatives were designed and synthesized to study the effect of molecular structures on the detection of nucleic acid. Contrastive studies revealed that the number of binding groups, the length of hydrophobic linking arm and the configuration of TPE molecule all play important roles ...
Shen Yanbing Y Key Laboratory of Industrial Fermentation Microbiology, Ministry of Education, College of Biotechnology, Tianjin University of Science & Technology, Tianjin, 300457, People's Republic of - - 2014
Hydroxypropyl-β-cyclodextrin (HP-β-CD) enhances steroid 1-dehydrogenation biotransformation by Arthrobacter simplex. In this work, HP-β-CD-induced improvement of A. simplex CPCC 140451 cell envelope permeability which had positive effects on the steroid bioconversion was confirmed by a comparative investigation which showed a lower dehydrogenase activity and higher cell permeability of the cells after ...
Heredia Romina Marisa RM Departamento de Biología Molecular, Universidad Nacional de Río Cuarto, - - 2014
The present study assessed the role of membrane component of Pseudomonas putida A (ATCC 12633) under chemical stress condition originated by treatment with tetradecyltrimethylammonium bromide (TTAB), a cationic surfactant. We examined changes in fatty acid (FA) composition and in the fluidity of the membranes of cells exposed to TTAB at ...
McDougle Daniel R DR University of Illinois, - - 2014
The endocannabinoids anandamide (AEA) and 2 -arachidonoylglycerol (2-AG) are arachidonic acid derivatives that are known to regulate human cardiovascular functions. CYP2J2 is the primary cytochrome P450 in the human heart and is most well-known for the metabolism of arachidonic acid (AA) to the biologically active epoxyeicosatrienoic acids (EETs). Herein we ...
Kanitkar Akanksha A Audubon Sugar Institute, Louisiana State University Agricultural Center, St. Gabriel, LA, USA Department of Biological and Agricultural Engineering, Louisiana State University and Agricultural Center, Baton Rouge, LA, - - 2014
In this study, a novel class of polyesters of glycerol, aconitic acid, and cinnamic acid were synthesized along with their hydroxyapatite (HA) composites, and studied for their potential application in bone defect repair. An osteogenic study was conducted with human adipose derived mesenchymal stem cells (hASCs) to determine the osteoinductive ...
Yu Huan H Department of Obstetrics and Gynecology, Peking University Third Hospital, Beijing 100191, - - 2014
Preeclampsia (PE) is associated with abnormal fatty acid beta-oxidation (FAO), especially metabolic disorders of long-chain fatty acid oxidation. The role of FAO dysfunction in inadequate invasion is unclear. The aim of this study was to explore the influence of various lengths fatty acids oxidation on invasiveness of trophoblasts. Primary human ...
Yarar Saniye S Deva Holding, Halkalı Merkez Mahallesi, Küçükçekmece , Istanbul , - - 2014
The construction of an L-lysine biosensor on ammonium-selective poly(vinylchloride) (PVC) membrane electrode is described in this study. The construction procedure occurs in two stages: (I) the preparation of ammonium-selective poly(vinylchloride) (PVC) membrane electrode and (II) the chemical immobilization of lysine oxidase on this ammonium-selective electrode by using glutaraldehyde. The ammonium ...
Senaweera Sameera - - 2014
This work describes the facile and selective mono-perfluoro and polyfluoroarylation of Meldrum's acid to generate a versatile synthon for highly fluorinated alpha-phenyl acetic acid derivatives which provide straightforward access to fluorinated building blocks. The reaction takes place quickly and most products were isolated without the need for chromatography. Importantly, this ...
Theofilopoulos Spyridon - - 2014
Cholestenoic acids are formed as intermediates in metabolism of cholesterol to bile acids, and the biosynthetic enzymes that generate cholestenoic acids are expressed in the mammalian CNS. Here, we evaluated the cholestenoic acid profile of mammalian cerebrospinal fluid (CSF) and determined that specific cholestenoic acids activate the liver X receptors ...
Natarajan Niranjana N Johns Hopkins University School of - - 2014
Recent studies have highlighted a myriad of ways in which the activity and composition of the gut microbiota can affect the host organism. A primary way in which the gut microbiota affect host physiology is by the production of metabolites, such as short chain fatty acids (SCFAs), which are subsequently ...
Sakihama Yuri Y Department of Chemical Science and Engineering, Graduate School of Engineering, Kobe University, 1-1 Rokkodai, Nada, Kobe 657-8501, - - 2014
The hydrolysis of lignocellulosic biomass liberates sugars, primarily glucose and xylose, which are subsequently converted to ethanol by microbial fermentation. The rapid and efficient fermentation of xylose by recombinant Saccharomyces cerevisiae strains is limited by weak acids generated during biomass pretreatment processes. In particular, acetic acid negatively affects cell growth, ...
Wang RuoWen R Molecular Sciences and Biomedicine Laboratory, State Key Laboratory for Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering and College of Biology, Collaborative Innovation Center for Chemistry and Molecular Medicine, Hunan University, Changsha 410082, - - 2014
An artificial nucleic acid analogue capable of self-assembly into duplex merely through hydrophobic interactions is presented. The replacement of Watson-Crick hydrogen bonding with strictly hydrophobic interactions has the potential to confer new properties and facilitate the construction of complex DNA nanodevices. To study how the hydrophobic effect works during the ...
Nejadsadeghi Leila L Department of Agronomy and Plant Breeding, University College of Agriculture and Natural Resources, University of Tehran, Karaj, - - 2014
Plant cells often increase cold tolerance by reprogramming their genes expression which results in adjusted metabolic alternations, a process enhanced under cold acclimation. In present study, we assessed the changes of membrane fatty acid compositions along with physio-biochemical indices like H2O2 and malondialdehyde (MDA) contents and lipoxygenase (LOX) activity during ...
Kamisaka Yasushi Y Bioproduction Research Institute, National Institute of Advanced Industrial Science and Technology (AIST), Tsukuba, Ibaraki, 305-8566, Japan, - - 2014
Palmitoleic acid (POA) has recently gained attention for its health benefits and as a potential resource for industrial feedstock. This study focused on the use of Saccharomyces cerevisiae, which has a high POA content but low lipid content, for POA production. We created an oleaginous S. cerevisiae as a dga1 ...
Tone Junichi J a Laboratory of Molecular Physiology and Genetics, Faculty of Agriculture , Ehime University , Matsuyama , - - 2014
Active transport systems for various amino acids operate in the vacuolar membrane of Saccharomyces cerevisiae. The gene families for vacuolar amino acid transporters were identified by reverse genetics experiments. In the AVT transporter family, Avt1p works for active uptake of amino acid into vacuole, and Avt3p, Avt4p, and Avt6p for ...
El Alaoui Meddy - - 2014
To date, several sensitive methods, based on radiolabeled elements or sterically hindered fluorochrome groups, are usually employed to screen phospholipase A (PLA) activities. Aiming at developing a convenient, specific, sensitive and continuous new ultraviolet (UV) spectrophotometric assay for PLA, we have synthesized a specific glycerophosphatidylcholine (PC) esterified on the position ...
Negri Pierre P Department of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, IN 46556, USA. - - 2014
A sheath-flow surface-enhanced Raman scattering (SERS) detector is demonstrated to provide chemical information enabling identification of the 20 proteinogenic l-amino acids separated by capillary zone electrophoresis (CZE). Amino acids were used to illustrate the chemical specificity of SERS detection from structurally related molecules. Analysis of the SERS electropherograms obtained from ...
Kang Chuanqing C State Key Laboratory of Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, 5625 Renmin Street, Changchun 130022, China. kangcq@ciac.ac.cn - - 2014
New simple hydrogelators containing the structural features of cyclic amino acids were investigated for water gelation through H-bonds from carboxylic acids and amino groups, showing for the first time the use of a single amino acid as a hydrogelator. The hydrogels were used for the synthesis of Pt and Ir ...
Xu Wei-Dong WD Department of Orthopedics, Changhai Hospital Affiliated to the Second Military Medical University, Shanghai, - - 2014
The present study first utilized a standardized shotgun proteomic analysis method to determine differences in protein expression of fibroblasts in the ligament between AS patients and healthy controls. Proteins extracted from primarily cultured FLLs from 35 AS patients and 10 normal subjects were analyzed by automated 2D-Nano-LC-ESI-MS/MS. Differentially expressed proteins ...
Huang Hui-Ying HY Department of Nutrition, China Medical University, Taichung 404, Taiwan, - - 2014
Some lactic acid bacteria (LAB) possess probiotic properties beneficial to human health. However, both gastric acid and bile salt have adverse influences on the survival and viability of ingested probiotics. This research investigated the changes in potential probiotic properties of LAB strains after treatment with simulated gastrointestinal (GI) conditions. Three ...
Abdel-Rahman Mohamed Ali MA Laboratory of Microbial Technology, Division of Systems Bioengineering, Department of Bioscience and Biotechnology, Faculty of Agriculture, Graduate School, Kyushu University, 6-10-1 Hakozaki, Higashi-ku, Fukuoka 812-8581, Japan; Botany and Microbiology Department, Faculty of Science (Boys), Al-Azhar University, Nasr City PN:11884, Cairo, Egypt. Electronic address: - - 2014
There has been tremendous growth in the production of optically pure l-lactic acid from lignocellulose-derived sugars. In this study, Enterococcus mundtii QU 25 was used to ferment a glucose/xylose mixture to l-lactic acid. Maintenance of the xylose concentration at greater than 10 g/L achieved homo-lactic acid fermentation and reduced the formation ...
Caputo Mariella M Department of Pharmacy, University of Salerno, Fisciano, Salerno, - - 2014
Stearoyl-CoA desaturase 1 (SCD1) is the rate limiting enzyme in unsaturated fatty acid biosynthesis. This enzyme has an important role in the regulation of hepatic lipogenesis and lipid oxidation, and alterations in these pathways may lead to several diseases. We examined, in HepG2 cell cultures, the mechanism of SCD1 regulation ...
Park Gwon Woo GW Department of Chemical and Bimolecular Engineering, KAIST, Yuseong-gu, Daejeon 305-701, - - 2014
Volatile fatty acids (VFAs) derived from waste organics were used as low cost carbon source, for high bioreactor productivity and titer, and multi-stage continuous high cell density culture (MSC-HCDC) process was employed for economic assessment of microbial lipids for biodiesel production. The simulation study used a lipid yield of 0.3g/g-VFAs, ...
Ghaddar Kassem K Molecular Physiology of the Cell, Université Libre de Bruxelles, IBMM, 6041 Gosselies, - - 2014
Many plasma membrane transporters are downregulated by ubiquitylation, endocytosis, and delivery to the lysosome, in response to various stimuli. We report here that two amino acid transporters of Saccharomyces cerevisiae, the general amino-acid permease (Gap1) and the arginine-specific permease (Can1), undergo ubiquitin-dependent downregulation in response to their substrates, and that ...
Masi Marco - - 2014
Two new phytotoxic sesquiterpenoid acids, named pyrenophoric acids B and C, were isolated together with the related pyrenophoric and abscisic acids from solid Bromus tectorum (cheatgrass) seed culture of the seed pathogen Pyrenophora semeniperda. This fungus has been proposed as a mycoherbicide for biocontrol of cheatgrass (Bromus tectorum), a Eurasian ...
Zhang Xiu-Feng XF College of Chemical Engineering, Hebei United University, Tangshan, Hebei 063009, China. Electronic address: - - 2014
Transferrin has shown potential in the delivery of anticancer drugs into primarily proliferating cancer cells that over-express transferrin receptors. Fulvic acid has a wide range of biological and pharmacological activities which caused widespread concerns, the interaction of fulvic acid with human serum transferrin (Tf) has great significance for gaining a ...
Jadoon Ayesha A Diabetes and Nutritional Sciences Division, School of Medicine, United - - 2014
Pre-eclampsia is characterized by placental hypoxia and dyslipidemia. Arachidonic and docosahexanoic acids are essential maternal nutrients for fetal development. They are transported via placental trophoblast cells by membrane and cytosolic fatty acid binding proteins. Others report the expressions of these proteins which are increased in hypoxic trophoblasts. Using bioinformatics, BeWo ...
Liu Wei W School of Chemistry and Materials Science, Ludong University, Yantai 264025, PR - - 2014
Biodiesel production has become an intense research area because of rapidly depleting energy reserves and increasing petroleum prices together with environmental concerns. This paper focused on the optimization of the catalytic performance in the esterification reaction of oleic acid for biodiesel production over the bifunctional catalyst organotriphosphonic acid-functionalized ferric alginate ...
Nikolov Nikolai G NG Division of Toxicology and Risk Assessment, National Food Institute, Technical University of Denmark, Mørkhøj Bygade 26, 2860 Søborg, Denmark. Electronic address: - - 2014
Ionization is a key factor in hERG K(+) channel blocking, and acids and zwitterions are known to be less probable hERG blockers than bases and neutral compounds. However, a considerable number of acidic compounds block hERG, and the physico-chemical attributes which discriminate acidic blockers from acidic non-blockers have not been ...
Hronská Helena H Department of Biochemical Technology, Faculty of Chemical and Food Technology, Slovak University of Technology, Radlinského 9, 812 37, Bratislava, Slovakia, - - 2014
The bacterial strains of the genus Nocardia were used for the bioconversion of fumaric acid to L-malic acid. The ability of the bacterial strain Nocardia sp. CCM 4837/A to produce L-malic acid from fumaric acid was investigated under various conditions. The optimal temperature for the bioconversion was approximately 37 °C, and ...
Otto Alexander A Department of Bioorganic Chemistry, Leibniz Institute of Plant Biochemistry, Weinberg 3, D-06120 Halle/Saale, - - 2014
Five sesquiterpene carboxylic acids (1-5) and one nor-sesquiterpene carboxylic acid (6) of the very rare ventricosane type, named penarines A-F, were isolated from fruiting bodies of the basidiomycete Hygrophorus penarius (Hygrophoraceae). This is the first report of (nor)-sesquiterpenes isolated from basidiocarps of the family Hygrophoraceae. Their structures were elucidated on ...
Thulasiraman Padmamalini - - 2014
A major obstacle in the use of retinoid therapy in cancer is the resistance to this agent in tumors. Retinoic acid facilitates the growth of mammary carcinoma cells which express high levels of fatty acid-binding protein 5 (FABP5). This protein delivers retinoic acid to peroxisome proliferator-activated receptor beta/delta (PPARbeta/delta) that ...
Xu Wenlong W Key Laboratory of Colloid and Interface Chemistry, Shandong University , Ministry of Education, Jinan 250100, P. R. - - 2014
Fatty acid bilayers are usually formed due to the hydrogen bonds between the protonated carboxyl (-COOH) and the deprotonated carboxylate (-COO(-)). Therefore, the formation of the bilayers must be at the pH around the pKa of the fatty acid, which is a narrow pH range (mostly about 7-9). Fatty acid ...
Hwang Buyng Su BS Department of Marine Biotechnology, Kunsan National University , Jeonbuk, 573-701, South - - 2014
Acuminolide A (1), along with pectenotoxin II (PTX-2), dinophysistoxin I (DTX-1), okadaic acid (OA), and 7-epi-PTX-2 seco acid, was isolated from a large-scale cultivation of the dinoflagellate Dinophysis acuminata. The new 33-membered macrolide 1 was characterized by detailed analysis of 2D NMR and MS data. Its relative stereochemistry was elucidated ...
Seo Min-Ju MJ Department of Bioscience and Biotechnology, Konkuk University, 1 Hwayang-dong, Gwangjin-Gu, Seoul, 143-701, Republic of - - 2014
The optimal conditions for the production of 5,8-dihydroxy-9(Z)-octadecenoic acid (5,8-diHOME) from oleic acid by whole recombinant Escherichia coli cells expressing diol synthase from Aspergillus nidulans were 40 °C, pH 7.5, 10 % (v/v) dimethyl sulfoxide, 35 g cells l(-1), and 12 g oleic acid l(-1) at 250 rpm in a 250 ml baffled flask. Under these ...
Tarlani Aliakbar A Chemistry & Chemical Engineering Research Center of Iran (CCERCI), Pazhouhesh Blvd., 17th Km. of Tehran- Karaj Highway, Tehran, Iran. Electronic address: - - 2014
In a new approach, shape controlled synthesis of zinc oxide nanostructures were carried out using a solvothermal route assisted amino acids such as l-Lysine (lysine), l-Cysteine (cysteine) and l-Arginine (arginine) as bifunctional species with (or without) urea or oxalic acid as additives which affect the pH of the reaction. Rod, ...
Maeda Dean Yoshimasa - - 2014
The G protein-coupled chemokine receptors CXCR1 and CXCR2 play key roles in inflammatory diseases and carcinogenesis. In inflammation, they activate and recruit polymorphonuclear cells (PMNs) through binding of the chemokines CXCL1 (CXCR1) and CXCL8 (CXCR1 and CXCR2). Structure-activity studies that examined the effect of a novel series of S-substituted 6-mercapto-N-phenyl-nicotinamides ...
Zhang Quanxuan - - 2014
A new simple and practical protocol for scalable synthesis of a novel library of propargylated and PEGylated alpha-hydroxy acids towards the preparation of 'clickable' polylactides was described. The overall synthesis starting from readily available propargyl alcohol, bromoacetaldehyde diethyl acetal and OEGs or PEGs was developed as a convenient procedure with ...
McCune Jade A JA QUILL, The Queen's University of Belfast, Belfast, BT9 5AG, UK. - - 2014
Gutmann Acceptor Number (AN) values have been determined for Brønsted acid-ionic liquid mixtures, over a wide compositional range. Four systems of general formula [C2mim][A]-HA (A(-) = bistriflamide, [NTf2](-); triflate, [OTf](-); mesylate, [OMs](-); or acetate, [OAc](-), [C2mim](+) = 1-ethyl-3-methylimidazolium cation) were studied. A library of Brønsted acidic systems of varying acidity ...
Popeijus Herman E HE Department of Human Biology, NUTRIM School for Nutrition, Toxicology and Metabolism, Maastricht University, PO Box 616, 6200 MD, Maastricht, The - - 2014
Fatty acids regulate PPARα activity, however, most studies evaluated the binding ability of fatty acids to PPARα, which does not necessarily results in PPARα transactivation. We therefore examined dose-response relationships between fatty acids and PPARα transactivation in HepG2 cells. Secretion of apoA-I protein as-well-as CPT1, ACO, and PPARα mRNA expression, ...
Iqbal Zeeshan Z Institute of Molecular Sciences & Bioinformatics, Lahore, - - 2014
Several models that predict where post-translational modifications are likely to occur and formulate the corresponding association rules are available to analyze the functional potential of a protein sequence, but an algorithm incorporating the functional groups of the involved amino acids in the sequence analyses process is not yet available. In ...
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