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O'Doherty Patrick J - - 2014
Abstract Amino acid biosynthesis forms part of an integrated stress response against oxidants in Saccharomyces cerevisiae and higher eukaryotes. Here we show an essential role of the L-lysine biosynthesis pathway in response to the oxidative stress condition induced by the lipid oxidant - linoleic acid hydroperoxide (LoaOOH), by means of ...
Li Juan J Chongqing Key Laboratory of Neurobiology, Chongqing 400016, - - 2014
Major depressive disorder (MDD) is a debilitating mood disorder with various etiopathological hypotheses. However the pathogenesis and diagnosis are still unclear. Peripheral blood mononuclear cells (PBMCs) have been shown to be well-suited to biomarker investigation in major depressive disorder (MDD), as well as to unveil the underlying pathogenesis of MDD. ...
Pelka Karin K Institute of Innate Immunity, University Hospital, University of Bonn, 53127 Bonn, - - 2014
Sensing of nucleic acids by TLRs is crucial in the host defense against viruses and bacteria. Unc-93 homolog B1 (UNC93B1) regulates the trafficking of nucleic acid-sensing TLRs from the endoplasmic reticulum to endolysosomes, where the TLRs encounter their respective ligands and become activated. In this article, we show that a ...
Papadopoulos Giorgos N GN Department of Chemistry, University of Athens, Panepistimiopolis 15771, Athens - - 2014
A fast and efficient visible-light metal-free hydroacylation of dialkyl azodicarboxylates is described. Among a variety of activated ketones, phenyl glyoxylic acid and its ethyl ester were identified as suitable photoorganocatalysts. A range of aliphatic and aromatic aldehydes were employed, thus leading to products in high to excellent yields.
Wang Shuping S State key Laboratory of Coordination Chemistry, School of Chemistry and Chemical Engineering, Nanjing University, PR - - 2014
Dimercaptopropanesulfonic acid (DMPS) has been approved for the treatment of arsenic poisoning through promoting arsenic excretion and modulating arsenic species. To clarify how DMPS regulates the excretion of arsenic species, we investigated the effects of DMPS on the biomethylation of arsenite (As(3+)) in HepG2 cells. In the experiments, we found ...
Abdel-Atty Mona M MM Pharmaceutical Chemistry Department, Faculty of Pharmacy, Misr International University, Cairo 11431, - - 2014
In this study, five series of (E)-6-(4-substituted phenyl)-4-oxohex-5-enoic acids IIb-f (E), (E)-3-(4-(substituted)-phenyl)acrylic acids IIIa-g (E), 4-(4-(substituted)phenylamino)-4-oxobutanoic acids VIa,b,e, 5-(4-(substituted)phenylamino)-5-oxopentanoic acids VIIa,f and 2-[(4-(substituted)phenyl) carbamoyl]benzoic acids VIIIa,e were designed and synthesized. Selected compounds were screened in vitro for their cytotoxic effect on 60 human NCI tumor cell lines. Compound IIf (E) ...
Kulandaivelu Umasankar U Medicinal Chemistry Research Division, Vaagdevi College of Pharmacy, Hanamkonda, Warangal 506 001, Andhra Pradesh, - - 2014
A series of hydroxamates (4a-4l) were prepared from p-aminobenzoic acid to inhibit HDAC8. The idea is to substitute rigid aromatic ring in place of less rigid piperazine ring of hydroxamates reported earlier by our group. It is expected to increase potency retaining the selectivity. Result obtained suggested that the modifications ...
Ozaki Yuya - - 2014
Proteorhodopsin (PR) is a light-driven proton pump found in marine bacteria. More than a thousand PRs are classified into blue-absorbing (λmax ~490 nm) and green-absorbing (λmax ~525 nm) PR. The color determinant is known to be at position 105, where blue-absorbing and green-absorbing PRs possess Gln and Leu, respectively. This ...
Antal Otilia - - 2014
Based on previous observations a potential resort in the therapy of the particularly radioresistant glioma would be its treatment with unsaturated fatty acids (UFAs) combined with irradiation. We evaluated the effect of different UFAs (arachidonic acid (AA), docosahexaenoic acid (DHA), gamma-linolenic acid (GLA), eicosapentaenoic acid (EPA) and oleic acid (OA)) ...
OsiƄska-Jaroszuk Monika M Department of Biochemistry, Maria Curie-Sklodowska University, Akademicka Street 19, 20-033, Lublin, Poland, - - 2014
The secretion of exopolysaccharides and oxalic acid in cultures of a white rot Ganoderma applanatum strain and a brown rot Tyromyces palustris strain were tested in terms of culture time, pH range, and temperature. The high yield of exopolysaccharides (EPS) required a moderate temperature of 28 °C for G. applanatum and ...
Zhuo Kelei K Collaborative Innovation Center of Henan Province for Green Manufacturing of Fine Chemicals, Key Laboratory of Green Chemical Media and Reactions, Ministry of Education, School of Chemistry and Chemical Engineering, Henan Normal University, Xinxiang, Henan 453007, PR China. Electronic address: - - 2015
The conversion of cellulosic biomass directly into valuable chemicals becomes a hot subject. Six novel acidic ionic liquids (ILs) based on 2-phenyl-2-imidazoline were synthesized and characterized by UV-VIS, TGA, and NMR. The novel acidic ionic liquids were investigated as catalysts for the hydrolysis of cellulose in 1-butyl-3-methylimidazolium chloride ([Bmim]Cl). The ...
Nath Subrata Deb SD Institute of Tissue Regeneration, Soonchunhyang University, Cheonan, South - - 2015
Polyelectrolyte complex (PEC) is formed when polymers with opposite charges are combined in solution. PECs are recently gaining attention as carriers for controlled release of drugs and proteins. Herein, bone morphogenetic protein-2 (BMP-2) was immobilized in a PEC of natural polymers, chitosan and hyaluronic acid. Charge-to-charge stoichiometry of the formed ...
Holl Eda K EK Durham, N.C. From the Departments of Surgery and Pathology, Duke University Medical - - 2014
Pathologic cutaneous scarring affects over 40 million people worldwide and costs billions of dollars annually. Understanding mechanisms of fibroblast activation and granulation tissue contraction is the first step toward preventing pathologic scarring. The authors hypothesize that nucleic acids increase fibroblast activation and cause granulation tissue contraction and that sequestration of ...
Shafqatullah - Institute of Chemical Sciences, University of Peshawar, Peshawar, Pakistan / Pakistan Council of Scientific and Industrial Research Peshawar, Peshawar, - - 2014
A simple and rapid chromatographic method has been developed for the simultaneous determination of five phenolic acids including Gallic acid, Chloroganic acid, Syringic acid, Benzoic acid and Vanillic acid by HPLC with UV-VIS detector. These Phenolic acids were separated by analytical column Intersil ODS-3 C18, a gradient elution system of ...
Mustufa Muhammad Ayaz MA Bilkent University, BilGen Genetics and Biotechnology Research Center, Deptt of Molecular Biology and Genetics, Ankara, Turkey / BIPS and Department of Biochemistry, Baqai Medical University, Karachi, - - 2014
Oleanolic acid (3β-hydroxy-olean-12-en-28-oic acid; OA-01), a pentacyclic triterpene, exhibit a wide range of pharmacological and biological activities. We have isolated oleanolic acid from methanolic extract of Periploca aphylla, collected from surroundings of Karachi in the month of February. Furthermore, four known and two new C-28 amino acid conjugates of oleanolic ...
Yu Q Q Department of Chemistry and Biochemistry, Concordia University, Montreal, Canada. - - 2014
LiYF4:Tm(3+)/Yb(3+) upconverting nanoparticles (UCNPs) were functionalized with the second generation photosensitizer 5,10,15,20-tetra(m-hydroxyphenyl)chlorin (m-THPC, Temoporfin, Foscan®). m-THPC was modified using 4-(bromomethyl)benzoic acid, which induced a bathochromic shift of the m-THPC blue absorption peak. The nanoconstruct causes up to 70% cell death under 980 nm irradiation.
Ma Jun - - 2014
Eight solutions containing phosphoric acid with concentration ranging from 2 mol L-1 to neat acid have been studied by picosecond pulse radiolysis. The absorbance of the secondary radical H2PO4• formed within 7 ps of the electron pulse is observed using pulse-probe method in the visible. Kinetic analysis shows that the ...
Xu Yun - - 2014
MON 87460 (D1) maize contains a gene that expresses the cold shock protein B (CSPB) from Bacillus subtilis to confer a yield advantage when yield is limited by water availability. This study evaluated the composition of grain from the D1-containing combined-trait maize hybrids: D1 × NK603, D1 × MON 89034 ...
Bera Anupam A Academy of Scientific and Innovative Research, Gijubhai Badheka Marg, Bhavnagar-364002 - - 2014
Production of polyhydroxyalkanoates (PHAs) from Jatropha biodiesel residues, namely crude glycerol and oil cake hydrolysate, has been reported previously. Halomonas hydrothermalis (MTCC accession no. 5445; NCBI Genbank accession no. GU938192), a wild marine strain, was used in the bio-synthesis. The present study was initiated to vary the properties of the ...
Souza Joanne M M JM Laboratório de Investigação Sistemática em Biotecnologia e Biodiversidade Molecular/LabISisBio, Instituto de Ciências Exatas e Naturais, Universidade Federal do Pará, Belém, PA, - - 2014
In this study, a protocol to induce high amount of friable callus of Boerhaavia paniculata RICH and a lipidomics technique were applied to investigate the profile of lipids to relate to those present in the roots of this plant that presented anti-inflammatory activity in the crude hexane extract. The callus ...
Ramalho Suelem D SD Department of Chemistry, Federal University of São Carlos, 13565-905 São Carlos, SP, Brazil, (phone: +55-16-33518061; fax: - - 2014
Cathepsins L (catL) and B play an important role in tumor progression and have been considered promising therapeutic targets in the development of novel anticancer agents. Using a bioactivity-guided fractionation, a series of triterpenoids was identified as a new class of competitive inhibitors towards cathepsin L with affinity values in ...
Rao Y Poorna Chandra - - 2014
Fatty acids are known to influence the ability of macrophages to generate reactive oxygen species (ROS). However the effect of elaidic acid (EA, 18:1 trans fatty acid) on ROS generation is not well studied. Rat peritoneal macrophages were enriched with elaidic acid by incubating the cells with 80 1M EA. ...
Liu Li-Jia LJ School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 100102, - - 2014
To study the absorption properties and mechanism of two important components, trolline and veratric acid, from the flowers of Trollius chinensis, in order to better understand the contribution of these two compounds to the effectiveness of these flowers. The human Caco-2 cell monolayer model was employed to study the transport ...
Shen Jie - - 2014
Abstract Correlation analysis based on chromatograms and pharmacological activities is essential for understanding the effective components in complex herbal medicines. In this report, HPLC and measurement of antioxidant properties were used to describe the active ingredients of Salvia miltiorrhiza injection (SMI). HPLC results showed that tanshinol, protocatechuic aldehyde, rosmarinic acid, ...
Ahmed Dildar D Department of Chemistry, Forman Christian College (A Chartered University), Lahore 54600, Pakistan. Electronic address: - - 2014
To conduct a comparative analysis of the phenolic and flavonoid contents and anti-oxidative potential of epicarp and mesocarp of Lagenaria siceraria fruit. The dried methanolic extracts of mesocarp and epicarp of the fruit and their hexane, chloroform, ethyl acetate, n-butanolic and aqueous fractions were subjected to antioxidant assays including ferric ...
Iqbal Pervaiz P Department of Chemistry, Forman Christian College (A Chartered University), Lahore 54600, - - 2014
To evaluate antioxidant and radical scavenging activities of organic extracts from fruit, roots and aerial parts of Fagonia cretica. Shed dried and powdered plant parts were initially extracted in methanol and subsequently partitioned in n-hexane, chloroform, ethyl acetate and 1-butanol successively. Antioxidant and radical scavenging potential of the methanol extracts ...
Kim Su-Yeon SY Functional Food and Nutrition Division, Kalasalingam University, Tamil Nadu 600001, - - 2014
In the present report, the effects of blanching, steaming, and high temperature/high pressure processing (HTHP) on the amino acid contents of commonly consumed Korean root vegetables, leaf vegetables, and pulses were evaluated using an Automatic Amino Acid Analyzer. The total amino acid content of the samples tested was between 3.38 ...
Min Kyoung-Jin KJ Department of Immunology, School of Medicine, Keimyung University, Daegu, - - 2014
Carnosic acid, which is one of extract components of rosemary, has anti-inflammatory, anti-oxidant, and anti-cancer effects. However, the anti-cancer effect of carnosic acid in human renal carcinoma cells is unknown. Flow cytometry analysis was used to examine the effects of carnosic acid on apoptosis, and Asp-Glu-Val-Asp-ase activity assay kit was ...
Shirani Kobra K Department of Pharmacodynamy and Toxicology, Faculty of Pharmacy, Mashhad University of Medical Sciences, Mashhad, I. R. - - 2014
Ferula szowitsiana has been widely used for medicinal purposes around the world. The anti-oxidant effect of F. szowitsiana had been proved. The current study aims to determine the protective effects of galbanic acid, a sesquiterpene coumarin from F. szowitsiana, against hydrogen peroxide (H2O2) - induced oxidative DNA damage in human ...
van der Straat Laura L a Microbial Systems and Synthetic Biology; Laboratory of Systems and Synthetic Biology; Wageningen University; Wageningen, the - - 2014
Itaconic acid is an important building block for the chemical industry. Currently, Aspergillus terreus is the main organism used for itaconic acid production. Due to the enormous citric acid production capacity of Aspergillus niger, this host is investigated as a potential itaconic acid production host. Several strategies have been tried ...
Potumarthi Ravichandra R Bio Engineering and Environmental Center (BEEC), Indian Institute of Chemical Technology (CSIR), Tarnaka, Hyderabad, 500 607, India, - - 2014
Two commonly used chemical pretreatment processes, sulphuric acid, and sodium hydroxide, were tested to provide comparative performance data. A connection between solid to liquid ratio (S/L) and sugars released was observed with an increase in S/L ratio between 0.02 and 0.2. Enzymatic digestibility of 1 M of NaOH-pretreated corncobs were released ...
Yang Yishan Y Food Science & Technology Programme, Department of Chemistry, National University of Singapore, Science Drive 4, Singapore 117543, - - 2014
This study evaluated the acid and heat resistance of Salmonella Enteritidis in simulated gastric fluid (pH2.0) and during thermal treatment (54-60°C), respectively, after adaptation to lactic acid (LA) or trisodium phosphate (TSP) at various pHs (pH5.3-9.0). The changes in membrane lipid composition and expression levels of RpoS and RpoH were ...
Singer Stacy D - - 2014
BackgroundTraditional canola (Brassica napus L.; AACC, 2n¿=¿38) cultivars yield seed oil with a relatively high proportion of ¿-linolenic acid (ALA; C18:3 cis¿9,12,15), which is desirable from a health perspective. Unfortunately, due to the instability of this fatty acid, elevated levels also result in oils that exhibit a short shelf life ...
Li Xu X North Carolina State University; Purdue - - 2014
Plant secondary metabolism is an active research area because of the unique and important roles the specialized metabolites have in the interaction of plants with their biotic and abiotic environment, the diversity and complexity of the compounds and their importance to human medicine. Thousands of natural accessions of Arabidopsis thaliana ...
Cao Xiaolin X Drug Product Development, Amgen Inc., Thousand Oaks, California, - - 2014
We report, for the first time, the identification of fatty acid particles in formulations containing the surfactant polysorbate 20. These fatty acid particles were observed in multiple mAb formulations during their expected shelf life under recommended storage conditions. The fatty acid particles were granular or sand-like in morphology and were ...
Fan Ye Y The Key Laboratory of Food Colloids and Biotechnology, Ministry of Education; School of Chemical and Material Engineering, Jiangnan University, 1800 Lihu Avenue, Wuxi, Jiangsu 214122, PR - - 2014
Unsaturated fatty acid liposomes (Ufasomes) have attracted interests because of the ready availability of unsaturated fatty acids and the simple assembly strategy. However, the colloidal instability of the ufasomes hinders them from applying in the fields of drug delivery and food additives. In the present work, conjugated linoleic acid (CLA) ...
Ornelas O O Department of Inorganic Chemistry and Materials Institute, University of Alicante, Apdo. 99- 03080, Alicante, Spain. - - 2014
The synthesis of nitrogenated carbon nanotubes (N-CNTs) with up to 6.1 wt% N, via the use of pyridine as the nitrogen containing carbon precursor, can provide a facile route to significantly enhance the low intrinsic specific capacitance of carbon nanotubes. The nitrogen functionalities determine this, at least, five-fold increase of ...
Moon Se-Kwon SK Changhae Advanced Institute of Technology, Changhae Ethanol Co., Ltd., Palbok-Dong 829, Dukjin-Gu, Jeonju, 561-203, Republic of - - 2014
The by-products of bioethanol production such as thin stillage (TS) and condensed distillers solubles (CDS) were used as a potential nitrogen source for economical production of lactic acid. The effect of those by-products and their concentrations on lactic acid fermentation were investigated using Lactobacillus paracasei CHB2121. Approximately, 6.7 g/L of yeast ...
Belkadhi Aïcha A Département de Biologie, Unité de Recherche de Physiologie et Biochimie de la tolérance des plantes aux contraintes abiotiques, Faculté des Sciences de Tunis, Campus Universitaire, 1060, Tunis, Tunisia, - - 2014
Interest in use of flax (Linum usitatissimum L.) as cadmium (Cd)-accumulating plant for phytoextraction of contaminated soils opened up a new and promising avenue toward improving tolerance of its varieties and cultivars to Cd stress. The aim of this study is to get insights into the mechanisms of Cd detoxification ...
Legrand-Poels Sylvie S University of Liege, GIGA-Signal Transduction, Laboratory of Virology and Immunology, Liege 4000, Belgium. Electronic address: - - 2014
Free fatty acids (FFAs) are metabolic intermediates that may be obtained through the diet or synthesized endogenously. In addition to serving as an important source of energy, they produce a variety of both beneficial and detrimental effects. They play essential roles as structural components of all cell membranes and as ...
Haag Nicola Leonard NL University of Hohenheim, State Institute of Agricultural Engineering and Bioenergy, Garbenstraße 9, Stuttgart 70599, Germany. Electronic address: - - 2014
A green biorefinery enables the material and energetic use of biomass via lactic acid and methane production. Different ensiling techniques were applied to maize and amaranth with the aim to increase the amount of lactic acid in the silage. In addition the methane formation potential of the ensiled samples and ...
Sepe Valentina - - 2014
Bile acids are signalling molecules interacting with the nuclear receptor FXR and the G-protein coupled receptor 1 (GP-BAR1/TGR5). GP-BAR1 is promising pharmacological target for the treatment of steato-hepatitis, type 2 diabetes and obesity. Endogenous bile acids and currently available semisynthetic bile acids are poorly selective toward GP-BAR1 and FXR. Thus, ...
Maher Amy Christine AC McMaster University - - 2014
In skeletal muscle the Rab-GTPase-activating protein TBC1D1 has been implicated in the regulation of fatty acid oxidation by an unknown mechanism. We determined whether TBC1D1 altered fatty acid utilization via changes in protein-mediated fatty acid transport and/or selected enzymes regulating mitochondrial fatty acid oxidation. We also determined the effects of ...
Kudoyarova Guzel R GR Institute of Biology, Ufa Science Centre, Russian Academy of Sciences, pr. Oktyabrya, 69, 450054 Ufa, Russia. Electronic address: - - 2014
Phytohormone production is one mechanism by which rhizobacteria can stimulate plant growth, but it is not clear whether the bacteria gain from this mechanism. The hypothesis that microbial-derived cytokinin phytohormones stimulate root exudation of amino acids was tested. The rhizosphere of wheat plants was drenched with the synthetic cytokinin trans-zeatin ...
Bone Simon M SM The University of New South Wales , Kensington, New South Wales 2052, - - 2014
Diagnostic tests performed in the field or at the site of patient care would benefit from using a combination of inexpensive, stable chemical reagents and simple instrumentation. Here, we have developed a universal "DNA-only Cascade" (DoC) to quantitatively detect target analytes with increased speed. The DoC utilizes quasi-circular structures consisting ...
Lian Sai S Key Laboratory of Analytical Chemistry for Life Science of Shaanxi Province, School of Chemistry and Chemical Engineering, Shaanxi Normal University, Xi'an 710062, Shaanxi Province, P. R. China. - - 2014
Hexokinase (HK)-catalyzed glucose phosphorylation plays an important role in the regulation of circulating glucose levels, so aberrant HK activity may result in various human diseases. Herein, we present a new strategy for highly sensitive detection of HK activity by use of Zr(4+)-coated magnetic beads (ZrMBs) for selective capture of HK-induced ...
Li Wei W Tasly R&D Institute, Tasly Pharmaceutical Co., Ltd., Tianjin 300410, - - 2014
Two new trimeric caffeic acids, named salvianolic acids T and U (1 and 2), were isolated from the underground part of Salvia miltiorrhiza. Their structures, consisting of three caffeic acid units, were determined based on extensive 1D- and 2D- spectroscopic analyses and electronic circular dichroism (ECD) calculations.
Wang Wenlian W College of Pharmaceutical Science, Soochow University, Suzhou, 215123, - - 2014
Five new ursane-type triterpenoidal saponins (1-5), together with five known ones (6-10), were isolated from the EtOH extract of the roots of Ilex cornuta. The structures of saponins 1-5 were elucidated as 19α-hydroxyurs-12-en-28-oic acid 3β-O-β-D-glucuronopyranoside (1), 19α-hydroxyurs-12-en-28-oic acid 3β-O-β-D-glucuronopyranoside-6-O-ethyl ester (2), 19α-hydroxyurs-12-en-28-oic acid 3β-O-α-L-arabinopyranosyl-(1→2)-β-D-glucuronopyranoside (3), 3β-O-[α-L-arabinopyranosyl-(1→2)-β-D-glucuronopyranosyl]-19α-hydroxyurs-12-en-28-oic acid 28-O-β-D-glucopyranosyl ester (4) ...
Chen Jian J Institute of Botany, Jiangsu Province and Chinese Academy of Sciences, Nanjing 210014, China; Department of Sustainable Organic Chemistry and Technology, Faculty of Bioscience Engineering, Ghent University, Coupure links 653, Ghent 9000, Belgium; Department of Pharmacognosy, China Pharmaceutical University, Nanjing 210009, - - 2014
The phytochemical investigation of natural products of Gynura divaricata led to the isolation of eleven caffeoylquinic acid derivatives. They were characterized by spectrometric methods as 5-O-caffeoylquinic acid (1), 5-O-p-coumaroylquinic acid (2), 5-O-feruloylquinic acid (3), methyl 5-O-caffeoylquinate (4), 3,4-dicaffeoylquinic acid (5), 3,5-dicaffeoylquinic acid (6), 4,5-dicaffeoylquinic acid (7), methyl 3,4-dicaffeoylquinate (8), methyl ...
Liu Wai-Nam WN Biochemistry Programme, School of Life Sciences, The Chinese University of Hong Kong, Shatin, Hong Kong, SAR, P.R. - - 2014
Conjugated linolenic acids (CLNAs) are a group of naturally occurring positional and geometrical isomers of the C18 polyunsaturated essential fatty acid, linolenic acid (LNA), with three conjugated double bonds (C18:3). Although previous research has demonstrated the growth-inhibitory effects of CLNA on a wide variety of cancer cell lines in vitro, their action mechanisms and ...
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