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Kim Min-A MA Department of Food Science and Biotechnology, Graduate School, Kyungpook National University, Daegu 702-701, Republic of - - 2014
Beauveria bassiana is a fungi that is well-known for demonstrating a resistance to environmental change. To confirm whether S-(-)-10,11-dihydroxyfarnesic acid methyl ester (DHFAME) produced by Beauveria bassiana KACC46831 causes phototoxicity when used for cosmetic purposes due to its anti-tyrosinase activity, we conducted in vitro and in vivo phototoxicity tests. There ...
Skolova Barbora - - 2014
Ceramides (Cer) are the central molecules in sphingolipid metabolism that participate in cellular signaling and also prevent excessive water loss by the skin. Previous studies showed that sphingosine-based Cer with a long 16C chain (CerNS16) and very long 24C-chain ceramides (CerNS24) differ in their biological actions. Increased levels of long ...
Park Dae-Hun - - 2014
The cosmetics market has rapidly increased over the last years. For example, in 2011 it reached 242.8 billion US dollars, which was a 3.9% increase compared to 2010. There have been many recent trials aimed at finding the functional ingredients for new cosmetics. Gallic acid is a phytochemical derived from ...
Yang Ge G University of Minnesota, The Hormel - - 2014
Caffeic acid (3,4-dihydroxycinnamic acid) is a well-known phenolic phytochemical present in coffee and reportedly has anticancer activities. However, the underlying molecular mechanisms and targeted proteins involved in the suppression of carcinogenesis by caffeic acid are not fully understood. In this study, we report that caffeic acid significantly inhibits colony formation ...
Takagi Y Y Kao Corporation, Tokyo, - - 2014
The pH at the surface of healthy human skin is around 5. Cleansing the skin with soap increases the pH of the skin, which then returns to a more acidic pH within a few hours. However, the effects of skin cleansing with soap over a long time on the pH ...
Lee Hae-Jin HJ Department of Dermatology, Yonsei University Wonju College of - - 2014
Long-standing or repeated skin barrier damage followed by atopic dermatitis (AD) is the initial step of the atopic march that eventually progresses to respiratory allergies. Maintenance of an acidic pH in the stratum corneum (SC) is an important factor for normal skin barrier function. We performed this study in order ...
Guha Lopamudra L Defence Research and Development Establishment, Jhansi Road, Gwalior, 474 002, Madhya Pradesh, - - 2014
Human skin emanations attract hungry female mosquitoes toward their host for blood feeding. In this study, we report the flight orientation and electroantennogram response of Aedes albopictus females to certain unsaturated acids and alcohols found in human skin. In the Y-tube olfactometer, odors of lactic acid and 2-methyl-3-pentanol attracted 54-65 % ...
Yevglevskis Maksims M Medicinal Chemistry, Department of Pharmacy & Pharmacology, University of Bath, Claverton Down, Bath BA2 7AY, United Kingdom. - - 2014
Mandelic acid is a chiral metabolite of the industrial pollutant styrene and is used in chemical skin peels, as a urinary antiseptic and as a component of other medicines. In humans, S-mandelic acid undergoes rapid chiral inversion to R-mandelic acid by an undefined pathway but it has been proposed to ...
Kerr Katherine R KR Division of Nutritional Sciences, University of Illinois, Urbana, Illinois; Department of Animal Sciences, University of Illinois, Urbana, - - 2014
Whole prey diets encourage species-typical behaviors making them popular in the zoo and home setting for captive exotic and domestic felids, respectively. We evaluated macronutrient, mineral, and long-chain fatty acid composition of 20 whole prey items: mice (1-2, 10-13, 21-25, 30-40, and 150-180 days of age); rats (1-4, 10-13, 21-25, ...
Iannitti Tommaso T School of Biomedical Sciences, University of Leeds, Mount Preston Street, Garstang building, Leeds, LS2 9JT, UK, - - 2014
In the field of aesthetic medicine there is an increasing demand for safe and effective hyaluronic acid (HA) fillers to counteract the aging process. We designed a study to evaluate the safety and histological biocompatibility of Aliaxin® Global Performance, a cross-linked HA filler and Viscoderm® Skinkò E, a product composed ...
Thomas Siji S Albany College of Pharmacy and Health Sciences, Albany, New - - 2014
The aim of this study was to assess the skin penetration, stability, and antioxidant effects of a α-tocopherol-lipoic acid codrug. To enhance penetration, we evaluated three microemulsions varying in water content and composition of the oil phase (isopropyl myristate with either monocaprylin or oleic acid). The codrug was incorporated at ...
Jaeger Teresa T Department of Dermatology and Allergy, Biederstein, Technische Universität München, DE-80802 Munich, Germany. - - 2014
Increased transepidermal water loss (TEWL) and decreased skin capacitance are characteristic features of the disturbed epidermal barrier in atopic eczema (AE). The "acid mantle", which is a slightly acidic film on the surface of the skin has led to the development of acidic emollients for skin care. In this context, ...
Wang Y Y Division of Dermatology, Department of Medicine, University of California, 3525 John Hopkins Court, San Diego, CA 92121, - - 2014
Previously, we demonstrated that Propionibacterium acnes, a human skin commensal bacterium, ferments glycerol into short-chain fatty acids, including propionic acid. Propionic acid suppressed the growth of Staphylococcus aureus USA300, a community-acquired methicillin-resistant bacterium, in vitro and in vivo. In this study, it is demonstrated that the anti-USA300 activity of propionic ...
Kim M - - 2014
To evaluate wrinkle improvement and safety of a novel cosmetic dissolving microneedle patches loaded with two active compounds with different hydrophilicities, namely ascorbic acid and retinyl retinoate. Clinical studies were performed on 24 Korean women for 12 weeks. Patients in group A were treated with retinyl retinoate-loaded dissolving microneedle patches ...
Maeda-Sano Katsura K Endowed Research Division of Human Welfare Sciences, Ochanomizu University, 2-1-1 Ohtsuka, Bunkyo-ku, Tokyo 112-8610, Japan; ALBION Co., Ltd., Hulic Ginza building, 1-7-10, Ginza, Chuo-ku, Tokyo 104-0061, - - 2014
Cyclic phosphatidic acid (cPA) is a naturally occurring phospholipid mediator and an analog of the growth factor-like phospholipid lysophosphatidic acid (LPA). cPA has a unique cyclic phosphate ring at the sn-2 and sn-3 positions of its glycerol backbone. We showed before that a metabolically stabilized cPA derivative, 2-carba-cPA, relieved osteoarthritis ...
Beydon Dominique D Institut National de Recherche et de Sécurité, Département Polluants et Santé, Rue du Morvan, 54519 Vandoeuvre Cedex, France. Electronic address: - - 2014
Ethyl to octyl esters of 2,4-dichlorophenoxy-acetic acids (2,4DAA), 2,4-dichlorophenoxy-propionic acids (2,4DPA) or 2,4-dichlorophenoxy-butyric acids (2,4DBA) are present in the most commonly used herbicides. Their use involves a significant risk of skin exposure, but little is known about the percutaneous flux of these substances. Studies have shown that percutaneous transition of ...
Budhiraja Abhishek A School of Pharmaceutical Sciences, Shoolini University , Solan, Moga , India - - 2014
Abstract The antibacterial and anti-inflammatory potential of rosemarinic acid (ROA), a naturally occurring ester of caffeic acid has been well reported. Antibacterial effect of ROA is attributed to nucleoid damage with an increase in spatial division and condensation of genetic material. ROA has been found dynamic against many human pathogenic ...
Ma Xue X Key Laboratory of the Analytical Chemistry for Life Science of Shaanxi Province, School of Chemistry and Chemical Engineering, Shaanxi Normal University, Xi'an, 710062, - - 2014
An aqueous solution of polyethylene glycol as a green solvent was employed for the first time to develop the ultrasound-assisted extraction of proanthocyanidins and chlorogenic acid from almond skin. The optimized extraction parameters were determined based on response surface methodology, and corresponded to an ultrasound power of 120 W, a ...
Bonnist Eleanor Y M EY Unilever R&D Colworth, Colworth Science Park, Sharnbrook, Bedfordshire, MK44 1LQ, - - 2014
To study and characterize the stratum corneum (SC) of dandruff scalp using in vivo Raman spectroscopy, to study how it compares with the non-dandruff scalp and to see the effect of treatment with a zinc pyrithione(ZnPTO)-based anti-dandruff shampoo. The scalp skin was measured using a recently developed in vivo Raman ...
Christeller John T JT The New Zealand Institute for Plant & Food Research, Palmerston North, New Zealand; Institute of Plant Sciences and Resources, Okayama University, Kurashiki, Okayama, - - 2014
Fruit extracts from apple, kiwifruit, feijoa, boysenberry, and blueberry were screened for the presence of lipase inhibitory compounds against lepidopteran larval midgut crude extracts. From 120 extracts, six showed significant inhibition with an extract from the peel of Malus × domestica cv. "Big Red" showing highest levels of inhibition. Because ...
Thitilertdecha Premrutai P Department of Pharmacy & Pharmacology, University of Bath, Bath, BA2 7AY, England; Center of Applied Thai Traditional Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, 2, Prannok Road, Bangkoknoi, Bangkok, 10700, Thailand. Electronic address: - - 2014
Clerodendrum petasites S. Moore (CP) has been widely prescribed in Thailand and neighbouring countries for both oral and topical administration to treat asthma, fever, cough, vomiting and skin diseases, for at least 30 years. To characterise polyphenolic compounds in the plant, to predict the feasibility of their topical absorption and ...
Ranjan Sahoo Manas M The Himalaya Drug Company, Makali, Tumkur Road, Bangalore 562 123 - - 2014
The genus Hydnocarpus (Flacourtiaceae) includes forty species that are spread across the globe. In the Indian System of Medicine, Hydnocarpus pentandrus (Buch.-Ham.) Oken. is primarily used for treating leprosy and other skin disorders. It is known as "Chaulmoogra" and is also used to treat other indications including constipation, inflammation, blood ...
Cartron Michaël L ML The Krebs Institute, Department of Molecular Biology and Biotechnology, University of Sheffield, Western Bank, Sheffield S10 2TN, United - - 2014
Human skin fatty acids are a potent aspect of our innate defences, giving surface protection against potentially invasive organisms. They provide an important parameter in determining the ecology of the skin microflora and alterations can lead to increased colonisation by pathogens such as Staphylococcus aureus. Harnessing skin fatty acids may ...
Deshpande Madhura M Department of Pharmaceutical Sciences, Bouvé College of Health Sciences, Northeastern University, Boston, MA, 02115, - - 2014
All-trans retinoic acid (ATRA) is known to have beneficial effects on skin. It has been used extensively for the treatment of photodamaged skin. To assess the effects of all-trans retinoic acid on the dermis, specifically its effect on hyaluronate (hyaluronic acid, HA) synthesis and inhibition, tissue-engineered human dermal equivalents were ...
Martínez-Lüscher J J INRA, Institut des Sciences de la Vigne et du Vin, UMR1287 EGFV, 210 Chemin de Leysotte, 33883 Villenave d'Ornon, France; University of Bordeaux, Institut des Sciences de la Vigne et du Vin, UMR1287 EGFV, 210 Chemin de Leysotte, 33883 Villenave d'Ornon, France; Universidad de Navarra, Grupo de Fisiología del Estrés en Plantas (Dpto. de Biología Ambiental), Unidad Asociada al CSIC, EEAD, Zaragoza e ICVV, Logroño, Irunlarrea, 1, 31008 Pamplona, - - 2014
Grapevine cv. Tempranillo fruit-bearing cuttings were exposed to supplemental ultraviolet-B (UV-B) radiation under controlled conditions, in order to study its effect on grape traits, ripening, amino acids and flavonoid profile. The plants were exposed to two doses of UV-B biologically effective (5.98 and 9.66kJm(-2)d(-1)), applied either from fruit set to ...
Cilurzo Francesco F Università degli Studi di Milano, Department of Pharmaceutical Sciences, via G. Colombo, 71, I-0133 Milano (phone: +39-02-50324635; fax: +39-02-50324657). - - 2014
The literature data suggest the capacity of biomacromolecules to permeate the human skin, even though such a transdermal permeation appears to be governed by physicochemical parameters which are significantly different compared to those ruling the skin permeation of small molecules. On these grounds, the present study was undertaken to investigate ...
Adibzadeh Nasim N Department of Animal and Marine Biotechnology, National Institute of Genetic Engineering and Biotechnology (NIGEB), P.O. Box: 14965/161, Sharek-e Pajoohesh Km 15, Tehran-Karaj Highway, Tehran, - - 2014
Pepsin-solubilized collagen (PSC) was extracted from the skin of sea cucumber Holothuria parva and was fractionally characterized. The PSC from H. parva skin consisted of three α1 chains (α1)3, in contrast to calf skin collagen type I with two α1 and one α2 chains (α1)2α2 with approximately 130 kDa each. The ...
Martins Madalena - - 2014
A novel transdermal hyaluronic acid (HA) conjugated with Bovine Serum Albumin (BSA) was developed in the form of solid-in-oil (S/O) nanodispersion (129.7 nm mean diameter). Ex vivo skin penetration analysis by fluorescence and confocal observation of histological skin sections revealed the ability of BSA/HA nanodispersions to cross the stratum corneum ...
Badawy Abdulla A-B AA School of Health Sciences, Cardiff Metropolitan University, Western Avenue, Cardiff CF5 2YB, - - 2014
Historical and clinical aspects of pellagra and its relationship to alcoholism are reviewed from a biochemical perspective. Pellagra is caused by deficiency of niacin (nicotinic acid) and/or its tryptophan (Trp) precursor and is compounded by B vitamin deficiencies. Existence on maize or sorghum diets and loss of or failure to ...
Cho Jae-Kwon JK Southwest Sea Fisheries Research Institute, National Fisheries Research and Development Institute (NFRDI), Yosu 556-823, Republic of - - 2014
In this study, we investigated the biochemical characteristics of the fish skins of four industrial species: olive flounder (Paralichthys olivaceus), black rockfish (Sebastes schlegeli), sea bass (Lateolabrax maculatus) and red sea bream (Pagrus major). There is high domestic demand in Korea for farming of these fish for human consumption. Crude ...
Seenivasagan T T Defence Research and Development Establishment, Jhansi Road, Gwalior, 474 002, MP, India, - - 2014
The flight orientation response of nonblood-fed and hungry Aedes albopictus females was studied in a Y-tube olfactometer at 10(-6) to 10(-2) g odor plumes of saturated carboxylic acids (C1-C20), in which C2-C18 were the main constituents of human skin emanations. Thirteen acids viz C1, C2, C3, C5, C6, C8 C9, C10, ...
Marepally Srujan S College of Pharmacy & Pharmaceutical Sciences, Florida A&M University, Tallahassee, FL 32307, - - 2014
Aim: Psoriasis is a chronic autoimmune skin disorder with substantial negative impact on the patient's quality of life. The present study was carried out to demonstrate the efficiency of a novel topical delivery system in the transport of two siRNAs for the treatment of psoriatic-like plaques. Materials & methods: We ...
Hashim Puziah P Halal Products Research Institute, Universiti Putra Malaysia, Putra Infoport, UPM Serdang, Selangor, - - 2014
Centella asiatica (Linn.) Urban is well known in promoting wound healing and provides significant benefits in skin care and therapeutic products formulation. Glycolic acid and vitamins also play a role in the enhancement of collagen and fibronectin synthesis. Here, we evaluate the specific effect of Centella asiatica (CA), vitamins, glycolic ...
Bai Jie J Department of Industrial Pharmacy, School of Chinese Pharmacy, Beijing University of Chinese Medicine, Beijing, - - 2014
Current work aimed to develop and evaluate a transdermal delivery system of hydrogel patch for ferulic acid to treat skin damage induced by UV radiation. VISCOMATE(TM) NP700, dihydroxy aluminium aminoacetate, glycerine, tartaric acid were used in combination in different ratios to design the hydrogel patch. In vitro release rate was ...
Marczyk Beata B Department of Cosmetology, Medical University of Lodz, Lodz, - - 2014
Pyruvic (alfa-keto acid) and salicylic (beta-hydroxy acid) acids are superficial peels frequently used in patients with acne vulgaris. The aim of the study was to compare the effect of 50% pyruvic and 30% salicylic peels on facial sebum secretion in patients with acne vulgaris, aged 13-30. The level of secreted ...
Jegasothy S Manjula SM President, Miami Skin Institute; Associate Clinical Professor of Dermatology, University of Miami, Miller School of - - 2014
The aim of this study was to evaluate the efficacy of a new topical low molecular nano-hyaluronic acid preparation in treating wrinkles, skin hydration, and skin elasticity in humans. Thirty-three women with an average age of 45.2 were studied for a period of eight weeks to measure the anti-wrinkle efficacy ...
Pannkuk Evan L EL Graduate Program of Environmental Science, Arkansas State University, P.O. Box 847, State University, Jonesboro, AR, 72467, USA, - - 2014
Pilosebaceous units found in the mammalian integument are composed of a hair follicle, the proximal portion of the hair shaft, a sebaceous gland, and the erector pili muscle. Pilosebaceous units release protective oils, or sebum, by holocrine secretion onto skin and hair through rupturing of sebocytes. Sebum is composed largely ...
Shin Jung-Hoon JH College of Pharmacy and Research Institute of Pharmaceutical Sciences, Kyungpook National University, 80 Daehak-ro, Buk-gu, Daegu, 702-701, South - - 2014
The stratum corneum (SC) is the outermost layer of skin that functions as a barrier and protects against environmental influences and transepidermal water loss. Its unique morphology consists of keratin-enriched corneocytes embedded in a distinctive mixture of lipids containing mainly ceramides, free fatty acids, and cholesterol. Ceramides are sphingolipids consisting ...
Chen Yang Y Department of Pharmaceutical Science, School of Pharmacy, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenyang, Liaoning, 110016, - - 2014
Saturated long-chain esters of isopulegol were synthesized and their activities as permeation enhancers for transdermal delivery of amlodipine and flurbiprofen were investigated, in contrast to the saturated fatty acids and isopulegol, as well as their physical mixtures. In vitro permeation experiments, confocal laser scanning microscopy (CLSM) and attenuated total reflection ...
Yutani Reiko R Department of Pharmaceutical Technology, Kobe Pharmaceutical - - 2014
To achieve efficient skin delivery of polyphenols, we prepared a novel oil-in-water (o/w)-type microemulsion (MESL) using sucrose laurate as a surfactant and ethanol, isopropyl myristate and water as other components. We examined its usefulness by in vitro studies on skin delivery of chlorogenic acid and resveratrol as hydrophilic and hydrophobic ...
Soica Codruţa C Faculty of Pharmacy, Victor Babeş University of Medicine and Pharmacy, 2nd Eftimie Murgu Sq., Timişoara 300041, Romania. - - 2014
Oleanolic and ursolic acids are natural triterpenic compounds with pentacyclic cholesterol-like structures which gives them very low water solubility, a significant disadvantage in terms of bioavailability. We previously reported the synthesis of inclusion complexes between these acids and cyclodextrins, as well as their in vivo evaluation on chemically induced skin ...
Ha Hyekyung - - 2014
Artemisia capillaries Thunb. (AC) has been used to treat inflammatory and hepatic disorders such as hepatic injury, hepatic fibrosis and hepatitis. However, the efficacy of AC against atopic dermatitis (AD), an inflammatory disease, has not been examined. In the present study, AC was evaluated for anti-inflammatory and anti-AD effects using ...
Sudhakara Reddy B B Department of Veterinary Medicine, College of Veterinary Science, Sri Venkateswara Veterinary University, Tirupati, Andhra Pradesh 5170502, India ; TVCC, C.V.Sc., Proddatur, Andhra Prandesh 516360, - - 2014
In the present study on recurrent pyoderma, dogs with a history of more than three episodes of skin infections in a period of one year were selected. The associated conditions and (or) underlying factors revealed upon thorough investigation were demodicosis, Malassezia dermatitis, flea infestation, hypothyroidism, keratinization disorder (seborrhea), combination of ...
Ching Congo Tak-Shing CT Department of Electrical Engineering, National Chi Nan University, Nantou, Taiwan, Republic of China ; Department of Photonics and Communication Engineering, Asia University, Taichung, Taiwan, Republic of - - 2014
The aims of this study were to investigate the most effective combination of physical forces from laser, electroporation, and reverse iontophoresis for noninvasive transdermal extraction of uric acid, and to develop a highly sensitive uric acid biosensor (UAB) for quantifying the uric acid extracted. It is believed that the combination ...
Lord Richard S RS Medical Affairs, Genova Diagnostics, Inc., Asheville, NC, - - 2014
Female, 70 FINAL DIAGNOSIS: Bile acid amino transferase deficiency Symptoms: Headache • indigestion • itching skin • nausea • vomiting - Clinical Procedure: - Specialty: Gastroenterology and Hepatology. Challenging differential diagnosis. Bile acid synthesis impairments are difficult to diagnose due to non-specific manifestations related to progressive failure to absorb essential ...
Fan Linpeng L State Key Laboratory for Modification of Chemical Fibers and Polymer Materials, Donghua University, Shanghai 201620, P.R. China; Biomaterials and Tissue Engineering Lab, College of Chemistry, Chemical Engineering and Biotechnology, Donghua University, Shanghai 201620, P.R. China; Australian Future Fibres Research and Innovation Centre, Institute for Frontier Materials, Deakin University, VIC 3217, - - 2013
Silk fibroin (SF) from Bombyx mori has many established excellent properties and has found various applications in the biomedical field. However, some abilities or capacities of SF still need improving to meet the need for using practically. Indeed, diverse SF-based composite biomaterials have been developed. Here we report the feasibility ...
Liang Yan - - 2013
Grape skin, a rich source of phytochemicals, has been reported to possess remarkable anti-obesity activity. Fatty acid synthase (FAS) is a key enzyme catalyzing the synthesis of fatty acid de novo, and has been considered as an anti-obesity target. To elucidate the anti-obesity mechanism of grape skin, we investigated the ...
Pilkington Suzanne M - - 2013
Eicosapentaenoic acid (EPA), abundant in oily fish, is reported to reduce skin inflammation and provide photoprotection, potential mechanisms include competition with arachidonic acid (AA) for metabolism by cyclooxygenases/lipoxygenases to less pro-inflammatory mediators. We thus examine impact of EPA intake on levels of AA, EPA and their resulting eicosanoids in human ...
van Smeden Jeroen - - 2013
An important feature of atopic eczema (AE) is a decreased skin barrier function. The stratum corneum (SC) lipids - comprised of ceramides (CERs), free fatty acids (FFAs) and cholesterol - fulfill a predominant role in the skin barrier function. In the present clinical study, the carbon chain length distribution of ...
Draelos Zoe - - 2013
Even facial pigmentation is considered a universal sign of youth and beauty in all cultures and at all ages in both men and women. The recent FDA concern about the safety of topical hydroquinone has provided the impetus for research into new pigment lightening alternatives in the cosmetic OTC market. ...
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