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Wang Y Y Division of Dermatology, Department of Medicine, University of California, 3525 John Hopkins Court, San Diego, CA 92121, - - 2014
Previously, we demonstrated that Propionibacterium acnes, a human skin commensal bacterium, ferments glycerol into short-chain fatty acids, including propionic acid. Propionic acid suppressed the growth of Staphylococcus aureus USA300, a community-acquired methicillin-resistant bacterium, in vitro and in vivo. In this study, it is demonstrated that the anti-USA300 activity of propionic ...
Cartron Michaël L ML The Krebs Institute, Department of Molecular Biology and Biotechnology, University of Sheffield, Western Bank, Sheffield S10 2TN, United - - 2014
Human skin fatty acids are a potent aspect of our innate defences, giving surface protection against potentially invasive organisms. They provide an important parameter in determining the ecology of the skin microflora and alterations can lead to increased colonisation by pathogens such as Staphylococcus aureus. Harnessing skin fatty acids may ...
Deshpande Madhura M Department of Pharmaceutical Sciences, Bouvé College of Health Sciences, Northeastern University, Boston, MA, 02115, - - 2014
All-trans retinoic acid (ATRA) is known to have beneficial effects on skin. It has been used extensively for the treatment of photodamaged skin. To assess the effects of all-trans retinoic acid on the dermis, specifically its effect on hyaluronate (hyaluronic acid, HA) synthesis and inhibition, tissue-engineered human dermal equivalents were ...
Martínez-Lüscher J J INRA, Institut des Sciences de la Vigne et du Vin, UMR1287 EGFV, 210 Chemin de Leysotte, 33883 Villenave d'Ornon, France; University of Bordeaux, Institut des Sciences de la Vigne et du Vin, UMR1287 EGFV, 210 Chemin de Leysotte, 33883 Villenave d'Ornon, France; Universidad de Navarra, Grupo de Fisiología del Estrés en Plantas (Dpto. de Biología Ambiental), Unidad Asociada al CSIC, EEAD, Zaragoza e ICVV, Logroño, Irunlarrea, 1, 31008 Pamplona, - - 2014
Grapevine cv. Tempranillo fruit-bearing cuttings were exposed to supplemental ultraviolet-B (UV-B) radiation under controlled conditions, in order to study its effect on grape traits, ripening, amino acids and flavonoid profile. The plants were exposed to two doses of UV-B biologically effective (5.98 and 9.66kJm(-2)d(-1)), applied either from fruit set to ...
Cilurzo Francesco F Università degli Studi di Milano, Department of Pharmaceutical Sciences, via G. Colombo, 71, I-0133 Milano (phone: +39-02-50324635; fax: +39-02-50324657). - - 2014
The literature data suggest the capacity of biomacromolecules to permeate the human skin, even though such a transdermal permeation appears to be governed by physicochemical parameters which are significantly different compared to those ruling the skin permeation of small molecules. On these grounds, the present study was undertaken to investigate ...
Adibzadeh Nasim N Department of Animal and Marine Biotechnology, National Institute of Genetic Engineering and Biotechnology (NIGEB), P.O. Box: 14965/161, Sharek-e Pajoohesh Km 15, Tehran-Karaj Highway, Tehran, - - 2014
Pepsin-solubilized collagen (PSC) was extracted from the skin of sea cucumber Holothuria parva and was fractionally characterized. The PSC from H. parva skin consisted of three α1 chains (α1)3, in contrast to calf skin collagen type I with two α1 and one α2 chains (α1)2α2 with approximately 130 kDa each. The ...
Martins Madalena - - 2014
A novel transdermal hyaluronic acid (HA) conjugated with Bovine Serum Albumin (BSA) was developed in the form of solid-in-oil (S/O) nanodispersion (129.7 nm mean diameter). Ex vivo skin penetration analysis by fluorescence and confocal observation of histological skin sections revealed the ability of BSA/HA nanodispersions to cross the stratum corneum ...
Badawy Abdulla A-B AA School of Health Sciences, Cardiff Metropolitan University, Western Avenue, Cardiff CF5 2YB, - - 2014
Historical and clinical aspects of pellagra and its relationship to alcoholism are reviewed from a biochemical perspective. Pellagra is caused by deficiency of niacin (nicotinic acid) and/or its tryptophan (Trp) precursor and is compounded by B vitamin deficiencies. Existence on maize or sorghum diets and loss of or failure to ...
Seenivasagan T T Defence Research and Development Establishment, Jhansi Road, Gwalior, 474 002, MP, India, - - 2014
The flight orientation response of nonblood-fed and hungry Aedes albopictus females was studied in a Y-tube olfactometer at 10(-6) to 10(-2) g odor plumes of saturated carboxylic acids (C1-C20), in which C2-C18 were the main constituents of human skin emanations. Thirteen acids viz C1, C2, C3, C5, C6, C8 C9, C10, ...
Marepally Srujan S College of Pharmacy & Pharmaceutical Sciences, Florida A&M University, Tallahassee, FL 32307, - - 2014
Aim: Psoriasis is a chronic autoimmune skin disorder with substantial negative impact on the patient's quality of life. The present study was carried out to demonstrate the efficiency of a novel topical delivery system in the transport of two siRNAs for the treatment of psoriatic-like plaques. Materials & methods: We ...
Hashim Puziah P Halal Products Research Institute, Universiti Putra Malaysia, Putra Infoport, UPM Serdang, Selangor, - - 2014
Centella asiatica (Linn.) Urban is well known in promoting wound healing and provides significant benefits in skin care and therapeutic products formulation. Glycolic acid and vitamins also play a role in the enhancement of collagen and fibronectin synthesis. Here, we evaluate the specific effect of Centella asiatica (CA), vitamins, glycolic ...
Bai Jie J Department of Industrial Pharmacy, School of Chinese Pharmacy, Beijing University of Chinese Medicine, Beijing, - - 2014
Current work aimed to develop and evaluate a transdermal delivery system of hydrogel patch for ferulic acid to treat skin damage induced by UV radiation. VISCOMATE(TM) NP700, dihydroxy aluminium aminoacetate, glycerine, tartaric acid were used in combination in different ratios to design the hydrogel patch. In vitro release rate was ...
Marczyk Beata B Department of Cosmetology, Medical University of Lodz, Lodz, - - 2014
Pyruvic (alfa-keto acid) and salicylic (beta-hydroxy acid) acids are superficial peels frequently used in patients with acne vulgaris. The aim of the study was to compare the effect of 50% pyruvic and 30% salicylic peels on facial sebum secretion in patients with acne vulgaris, aged 13-30. The level of secreted ...
Jegasothy S Manjula SM President, Miami Skin Institute; Associate Clinical Professor of Dermatology, University of Miami, Miller School of - - 2014
Background: The aim of this study was to evaluate the efficacy of a new topical low molecular nano-hyaluronic acid preparation in treating wrinkles, skin hydration, and skin elasticity in humans. Methods: Thirty-three women with an average age of 45.2 were studied for a period of eight weeks to measure the ...
Pannkuk Evan L EL Graduate Program of Environmental Science, Arkansas State University, P.O. Box 847, State University, Jonesboro, AR, 72467, USA, - - 2014
Pilosebaceous units found in the mammalian integument are composed of a hair follicle, the proximal portion of the hair shaft, a sebaceous gland, and the erector pili muscle. Pilosebaceous units release protective oils, or sebum, by holocrine secretion onto skin and hair through rupturing of sebocytes. Sebum is composed largely ...
Shin Jung-Hoon JH College of Pharmacy and Research Institute of Pharmaceutical Sciences, Kyungpook National University, 80 Daehak-ro, Buk-gu, Daegu, 702-701, South - - 2014
The stratum corneum (SC) is the outermost layer of skin that functions as a barrier and protects against environmental influences and transepidermal water loss. Its unique morphology consists of keratin-enriched corneocytes embedded in a distinctive mixture of lipids containing mainly ceramides, free fatty acids, and cholesterol. Ceramides are sphingolipids consisting ...
Chen Yang Y Department of Pharmaceutical Science, School of Pharmacy, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenyang, Liaoning, 110016, - - 2014
Saturated long-chain esters of isopulegol were synthesized and their activities as permeation enhancers for transdermal delivery of amlodipine and flurbiprofen were investigated, in contrast to the saturated fatty acids and isopulegol, as well as their physical mixtures. In vitro permeation experiments, confocal laser scanning microscopy (CLSM) and attenuated total reflection ...
Yutani Reiko R Department of Pharmaceutical Technology, Kobe Pharmaceutical - - 2014
To achieve efficient skin delivery of polyphenols, we prepared a novel oil-in-water (o/w)-type microemulsion (MESL) using sucrose laurate as a surfactant and ethanol, isopropyl myristate and water as other components. We examined its usefulness by in vitro studies on skin delivery of chlorogenic acid and resveratrol as hydrophilic and hydrophobic ...
Lord Richard S RS Medical Affairs, Genova Diagnostics, Inc., Asheville, NC, - - 2014
Patient: Female, 70 Final Diagnosis: Bile acid amino transferase deficiency Symptoms: Headache • indigestion • itching skin • nausea • vomiting Medication: - Clinical Procedure: - Specialty: Gastroenterology and Hepatology. Challenging differential diagnosis. Bile acid synthesis impairments are difficult to diagnose due to non-specific manifestations related to progressive failure to ...
Ha Hyekyung - - 2014
Artemisia capillaries Thunb. (AC) has been used to treat inflammatory and hepatic disorders such as hepatic injury, hepatic fibrosis and hepatitis. However, the efficacy of AC against atopic dermatitis (AD), an inflammatory disease, has not been examined. In the present study, AC was evaluated for anti-inflammatory and anti-AD effects using ...
Fan Linpeng L State Key Laboratory for Modification of Chemical Fibers and Polymer Materials, Donghua University, Shanghai 201620, P.R. China; Biomaterials and Tissue Engineering Lab, College of Chemistry, Chemical Engineering and Biotechnology, Donghua University, Shanghai 201620, P.R. China; Australian Future Fibres Research and Innovation Centre, Institute for Frontier Materials, Deakin University, VIC 3217, - - 2013
Silk fibroin (SF) from Bombyx mori has many established excellent properties and has found various applications in the biomedical field. However, some abilities or capacities of SF still need improving to meet the need for using practically. Indeed, diverse SF-based composite biomaterials have been developed. Here we report the feasibility ...
Liang Yan - - 2013
Grape skin, a rich source of phytochemicals, has been reported to possess remarkable anti-obesity activity. Fatty acid synthase (FAS) is a key enzyme catalyzing the synthesis of fatty acid de novo, and has been considered as an anti-obesity target. To elucidate the anti-obesity mechanism of grape skin, we investigated the ...
Pilkington Suzanne M - - 2013
Eicosapentaenoic acid (EPA), abundant in oily fish, is reported to reduce skin inflammation and provide photoprotection, potential mechanisms include competition with arachidonic acid (AA) for metabolism by cyclooxygenases/lipoxygenases to less pro-inflammatory mediators. We thus examine impact of EPA intake on levels of AA, EPA and their resulting eicosanoids in human ...
van Smeden Jeroen - - 2013
An important feature of atopic eczema (AE) is a decreased skin barrier function. The stratum corneum (SC) lipids - comprised of ceramides (CERs), free fatty acids (FFAs) and cholesterol - fulfill a predominant role in the skin barrier function. In the present clinical study, the carbon chain length distribution of ...
Draelos Zoe - - 2013
Even facial pigmentation is considered a universal sign of youth and beauty in all cultures and at all ages in both men and women. The recent FDA concern about the safety of topical hydroquinone has provided the impetus for research into new pigment lightening alternatives in the cosmetic OTC market. ...
Tavaria Freni K FK Center for Biotechnology and Fine Chemistry (CBQF-LAE), Portuguese Catholic University, Porto, - - 2013
In an effort to bypass the adverse secondary effects attributed to the traditional therapeutic approaches used to treat skin disorders (such as atopic dermatitis), alternative antimicrobials have recently been suggested. One such antimicrobial is chitosan, owing to the already proved biological properties associated with its use. However, the influence of ...
Truong-Bolduc Que Chi - - 2013
Background. Staphylococcus aureus colonizes skin in the presence of antimicrobial fatty acids and polyamines. The chromosomally encoded Tet38 efflux transporter confers resistance to tetracycline and fitness in abscesses, but its natural substrates and those of the Nor quinolone efflux pumps are unknown.Methods. Susceptibility of tet38 and other pump mutants to and pump ...
Wilkes Kail - - 2013
Chokeberries are an excellent source of polyphenols, but their fate during juice processing and storage are unknown. The stability of anthocyanin's, total proanthocyanidins, hydroxycinnamic acids, and flavonols at various stages of juice processing and over six months of storage at 25 oC were determined. Flavonols, total proanthocyanidins and hydroxycinnamic acids ...
Clifford Alexander M - - 2013
This study investigates the role of branchial and extrabranchial processes in acid-base regulation in the Pacific Hagfish (Eptatretus stoutii). Hagfish were injected with one of the following solutions: acid saline (250mM HCl [pH=0.60], 250mM NaCl), alkaline saline (250mM NaHCO3, 250mM NaCl, [pH≈8.43]) or control saline (500mM NaCl) in order to ...
Wang Yanhan - - 2013
Increasing evidence demonstrates that commensal microorganisms in the human skin microbiome help fight pathogens and maintain homeostasis of the microbiome. However, it is unclear how these microorganisms maintain biological balance when one of them overgrows. The overgrowth of Propionibacterium acnes (P. acnes), a commensal skin bacterium, has been associated with ...
Zupan Anka - - 2013
Bitter pit is an important Ca2+ deficiency disorder of apple fruit (Malus domestica Borkh.), with symptoms, necrotic spots, developing during storage. The objective of this study was to determine phenolic compounds and their contents in bitter pit in comparison to healthy skin and pulp using HPLC-MS2. The experiment was carried ...
Knechtle Philipp - - 2013
Human fungal infections represent a therapeutic challenge. Although effective strategies for treatment are available, resistance is spreading and many therapies have unacceptable side effects. A clear need for novel antifungal targets and molecules is thus emerging. Here, we present the identification and characterisation of the plant derived diyne-furan fatty acid ...
Burnett Christina L CL Cosmetic Ingredient Review, 1101 17th Street, NW, Suite, 412, Washington, DC 20036, USA. Email: - - 2013
The Cosmetic Ingredient Review Expert Panel (Panel) reviewed the safety of α-amino acids, which function primarily as hair- and skin-conditioning agents in cosmetic products. The safety of α-amino acids as direct food additives has been well established based on extensive research through acute and chronic dietary exposures. The Panel focused ...
Sharma Richa - - 2013
Acne vulgaris is a chronic skin disorder leading to inflammation as a result of the production of reactive oxygen species due to the active involvement of Propionibacterium acnes (P. acnes) in the infection site of the skin. The current study was designed to assess the potential of the leaf extract ...
Wang Lin - - 2014
The collagen in Amur sturgeon was extracted by pepsin digestion and separated into two fractions, P2.4 (92.40%) and P4.0 (2.16%), by sodium chloride precipitation. SDS-PAGE and amino acid profile suggested that the P2.4 and P4.0 might be classified as type I collagen (PSC-I) and type V collagen (PSC-V), respectively. These ...
Kim Bora - - 2013
Peroxisome proliferator-activated receptors (PPAR)-α plays an important role in epidermal differentiation and barrier recovery, and topical treatment with PPAR-α agonists restores epidermal homeostasis in essential fatty acid deficiency and permeability barrier in skin disruptions. Therefore, we performed structure-based pharmacophore screening to search for a novel PPAR-α agonist. Caffeic acid was ...
Zouboulis C C - - 2013
Hyperseborrhoea has been considered as a major aetiopathogenetic factor of acne. However, changes in sebaceous gland activity not only correlate with seborrhoea but also with alterations in sebum fatty acid composition. Current findings indicate that sebum lipid fractions with proinflammatory properties and inflammatory tissue cascades are associated in the process ...
Downie Jeanine B - - 2013
Although the use of the hyaluronic acid with cohesive polydensified matrix hyaluronic acid has been well explored in subjects with lighter skin (i.e., Fitzpatrick skin types I, II, and III), further exploration in subjects with Fitzpatrick skin types IV, V, and IV is warranted. The primary purpose of the study ...
Külkamp-Guerreiro Irene Clemes - - 2013
To evaluate the effects of lipoic acid (thioctic acid) topical application on wound healing on rats skin, and the consequences of lipoic acid nanoencapsulation on this process. The model used was the healing activity on wounds induced by surgical incision on rats skin (n = 44). The parameters analyzed (11 ...
Rabionet Mariona - - 2013
The lipid-rich stratum corneum functions as a barrier against pathogens and desiccation inter alia by an unbroken meshwork of extracellular lipid lamellae. These lamellae are composed of cholesterol, fatty acids and ceramides in an equimolar ratio. The huge class of skin ceramides consists of 3 groups, I) "classical" long and ...
Khan Haseeb A HA Department of Biochemistry, College of Science, King Saud University, Riyadh, Saudi - - 2014
Skin lipids play an important role in the regulation of cutaneous water loss (CWL). Earlier studies have shown that Saudi desert birds exhibit a tendency of reduced CWL than birds from temperate environment due to adaptive changes in composition of their skin lipids. In this study, we used thin-layer chromatography ...
Rosas-Ramírez Daniel - - 2013
Native to tropical America, Ipomoea batatas has been cultivated for over 5000 years in Mexico. The yellow-skinned tuber crop variety, with an orange flesh, has a higher nutritional value than potato. Raw sweet potato can cause a purge due to its resin glycoside content. Purification of the chloroform-soluble resin glycosides ...
Vávrová KateĊ™ina - - 2013
Mutations in the filaggrin gene (FLG) are strongly associated with common dermatological disorders such as atopic dermatitis. However, the exact underlying pathomechanism is still ambiguous. Here, we investigated the impact of FLG on skin lipid composition, organization and skin acidification using a FLG knock down (FLG-) skin construct. Initially, sodium/hydrogen ...
Regensburger Johannes - - 2013
UVA radiation plays an important role for adverse reactions in human tissue. UVA penetrates epidermis and dermis of skin being absorbed by various biomolecules, especially endogenous photosensitizers. This may generate deleterious singlet oxygen ((1)O2) that oxidizes fatty acids in cell membranes, lipoproteins, and other lipid-containing structures such as the epidermal ...
Tawada Chisato - - 2013
Ceramide (CER) with long-chain fatty acids (FAs) in human stratum corneum (SC) is important for the skin barrier functions. Changes in the CER profile have been associated with abnormal permeability of dermatoses such as atopic dermatitis (AD) and psoriasis. In addition, interferon-γ (IFN-γ) has been known to be abundant in ...
Sonsmann F K - - 2013
Skin cleansers for occupational use are manufactured for different types and degrees of soiling without common, legally binding requirements for product testing. This leads to different, manufacturer-specific test methods and a lack of comparable information on skin cleansing products. The aim of this investigation was to validate a newly developed ...
Dahlin Jakob - - 2013
Trifluoroacetic acid is a very strong carboxylic acid. The acid has been suspected to have similar toxic effects as hydrofluoric acid on skin contact. Hydrofluoric acid is highly toxic, owing to skin penetration by fluoride ions. A spill of hydrofluoric acid on the skin may be fatal. As trifluoroacetic acid ...
Dong Xiao-Qian - - 2013
We have established a simple method for preparing large quantities of A-type dimers from peanut skin and persimmon for further structure-activity relationship study. Peanut skins were defatted with hexane and oligomeric proanthoancyaindins were extracted from it with 20% of methanol, and the extract was fractionated with ethyl acetate. Persimmon tannin ...
Casas J W - - 2013
The aim of this study was to determine if the EpiDerm™ reconstructed human skin model (MatTek Corp.) could be an acceptable alternative to the ISO 10993-required rabbit skin irritation test for assessing medical device biocompatibility. Eleven medical device polymers were tested. Four extracts were prepared per polymer, two each with ...
Fischer Carol L - - 2013
Lauric acid (C12:0) and sapienic acid (C16:1Δ6) derived from human sebaceous triglycerides are potent antimicrobials found at the human skin surface. Long-chain bases (sphingosine, dihydrosphingosine and 6-hydroxysphingosine) are also potent and broad-acting antimicrobials normally present at the skin surface. These antimicrobials are generated through the action of ceramidases on ceramides ...
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