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Jia Jing J Department of Chemistry, Capital Normal University, Beijing, - - 2014
Carboxymethyl α-cyclodextrin immobilized Fe3O4 magnetic nanoparticles (CM-α-CD-Fe3O4) were synthesized for the selectively adsorptive extraction of five phenylarsonic acids including p-amino phenylarsonic acid, p-nitro phenylarsonic acid, p-hydroxy phenylarsonic acid, p-acylamino phenylarsonic acid and p-hydroxy-3-nitro phenylarsonic acid in chicken tissue. Using ultra performance liquid chromatography coupled with tandem mass spectrometry (UPLC-MS/MS), a ...
Lord Richard S RS Medical Affairs, Genova Diagnostics, Inc., Asheville, NC, - - 2014
Female, 70 FINAL DIAGNOSIS: Bile acid amino transferase deficiency Symptoms: Headache • indigestion • itching skin • nausea • vomiting - Clinical Procedure: - Specialty: Gastroenterology and Hepatology. Challenging differential diagnosis. Bile acid synthesis impairments are difficult to diagnose due to non-specific manifestations related to progressive failure to absorb essential ...
Fan Linpeng L State Key Laboratory for Modification of Chemical Fibers and Polymer Materials, Donghua University, Shanghai 201620, P.R. China; Biomaterials and Tissue Engineering Lab, College of Chemistry, Chemical Engineering and Biotechnology, Donghua University, Shanghai 201620, P.R. China; Australian Future Fibres Research and Innovation Centre, Institute for Frontier Materials, Deakin University, VIC 3217, - - 2013
Silk fibroin (SF) from Bombyx mori has many established excellent properties and has found various applications in the biomedical field. However, some abilities or capacities of SF still need improving to meet the need for using practically. Indeed, diverse SF-based composite biomaterials have been developed. Here we report the feasibility ...
Liang Yan - - 2013
Grape skin, a rich source of phytochemicals, has been reported to possess remarkable anti-obesity activity. Fatty acid synthase (FAS) is a key enzyme catalyzing the synthesis of fatty acid de novo, and has been considered as an anti-obesity target. To elucidate the anti-obesity mechanism of grape skin, we investigated the ...
Pilkington Suzanne M - - 2013
Eicosapentaenoic acid (EPA), abundant in oily fish, is reported to reduce skin inflammation and provide photoprotection, potential mechanisms include competition with arachidonic acid (AA) for metabolism by cyclooxygenases/lipoxygenases to less pro-inflammatory mediators. We thus examine impact of EPA intake on levels of AA, EPA and their resulting eicosanoids in human ...
van Smeden Jeroen - - 2013
An important feature of atopic eczema (AE) is a decreased skin barrier function. The stratum corneum (SC) lipids - comprised of ceramides (CERs), free fatty acids (FFAs) and cholesterol - fulfill a predominant role in the skin barrier function. In the present clinical study, the carbon chain length distribution of ...
Draelos Zoe - - 2013
Even facial pigmentation is considered a universal sign of youth and beauty in all cultures and at all ages in both men and women. The recent FDA concern about the safety of topical hydroquinone has provided the impetus for research into new pigment lightening alternatives in the cosmetic OTC market. ...
Tavaria Freni K FK Center for Biotechnology and Fine Chemistry (CBQF-LAE), Portuguese Catholic University, Porto, - - 2013
In an effort to bypass the adverse secondary effects attributed to the traditional therapeutic approaches used to treat skin disorders (such as atopic dermatitis), alternative antimicrobials have recently been suggested. One such antimicrobial is chitosan, owing to the already proved biological properties associated with its use. However, the influence of ...
Truong-Bolduc Que Chi - - 2013
Background. Staphylococcus aureus colonizes skin in the presence of antimicrobial fatty acids and polyamines. The chromosomally encoded Tet38 efflux transporter confers resistance to tetracycline and fitness in abscesses, but its natural substrates and those of the Nor quinolone efflux pumps are unknown.Methods. Susceptibility of tet38 and other pump mutants to and pump ...
Wilkes Kail - - 2013
Chokeberries are an excellent source of polyphenols, but their fate during juice processing and storage are unknown. The stability of anthocyanin's, total proanthocyanidins, hydroxycinnamic acids, and flavonols at various stages of juice processing and over six months of storage at 25 oC were determined. Flavonols, total proanthocyanidins and hydroxycinnamic acids ...
Clifford Alexander M - - 2013
This study investigates the role of branchial and extrabranchial processes in acid-base regulation in the Pacific Hagfish (Eptatretus stoutii). Hagfish were injected with one of the following solutions: acid saline (250mM HCl [pH=0.60], 250mM NaCl), alkaline saline (250mM NaHCO3, 250mM NaCl, [pH≈8.43]) or control saline (500mM NaCl) in order to ...
Wang Yanhan - - 2013
Increasing evidence demonstrates that commensal microorganisms in the human skin microbiome help fight pathogens and maintain homeostasis of the microbiome. However, it is unclear how these microorganisms maintain biological balance when one of them overgrows. The overgrowth of Propionibacterium acnes (P. acnes), a commensal skin bacterium, has been associated with ...
Zupan Anka - - 2013
Bitter pit is an important Ca2+ deficiency disorder of apple fruit (Malus domestica Borkh.), with symptoms, necrotic spots, developing during storage. The objective of this study was to determine phenolic compounds and their contents in bitter pit in comparison to healthy skin and pulp using HPLC-MS2. The experiment was carried ...
Knechtle Philipp - - 2013
Human fungal infections represent a therapeutic challenge. Although effective strategies for treatment are available, resistance is spreading and many therapies have unacceptable side effects. A clear need for novel antifungal targets and molecules is thus emerging. Here, we present the identification and characterisation of the plant derived diyne-furan fatty acid ...
Burnett Christina L CL Cosmetic Ingredient Review, 1101 17th Street, NW, Suite, 412, Washington, DC 20036, USA. Email: - - 2013
The Cosmetic Ingredient Review Expert Panel (Panel) reviewed the safety of α-amino acids, which function primarily as hair- and skin-conditioning agents in cosmetic products. The safety of α-amino acids as direct food additives has been well established based on extensive research through acute and chronic dietary exposures. The Panel focused ...
Sharma Richa - - 2013
Acne vulgaris is a chronic skin disorder leading to inflammation as a result of the production of reactive oxygen species due to the active involvement of Propionibacterium acnes (P. acnes) in the infection site of the skin. The current study was designed to assess the potential of the leaf extract ...
Wang Lin - - 2014
The collagen in Amur sturgeon was extracted by pepsin digestion and separated into two fractions, P2.4 (92.40%) and P4.0 (2.16%), by sodium chloride precipitation. SDS-PAGE and amino acid profile suggested that the P2.4 and P4.0 might be classified as type I collagen (PSC-I) and type V collagen (PSC-V), respectively. These ...
Kim Bora - - 2013
Peroxisome proliferator-activated receptors (PPAR)-α plays an important role in epidermal differentiation and barrier recovery, and topical treatment with PPAR-α agonists restores epidermal homeostasis in essential fatty acid deficiency and permeability barrier in skin disruptions. Therefore, we performed structure-based pharmacophore screening to search for a novel PPAR-α agonist. Caffeic acid was ...
Zouboulis C C - - 2013
Hyperseborrhoea has been considered as a major aetiopathogenetic factor of acne. However, changes in sebaceous gland activity not only correlate with seborrhoea but also with alterations in sebum fatty acid composition. Current findings indicate that sebum lipid fractions with proinflammatory properties and inflammatory tissue cascades are associated in the process ...
Downie Jeanine B - - 2013
Although the use of the hyaluronic acid with cohesive polydensified matrix hyaluronic acid has been well explored in subjects with lighter skin (i.e., Fitzpatrick skin types I, II, and III), further exploration in subjects with Fitzpatrick skin types IV, V, and IV is warranted. The primary purpose of the study ...
Külkamp-Guerreiro Irene Clemes - - 2013
To evaluate the effects of lipoic acid (thioctic acid) topical application on wound healing on rats skin, and the consequences of lipoic acid nanoencapsulation on this process. The model used was the healing activity on wounds induced by surgical incision on rats skin (n = 44). The parameters analyzed (11 ...
Rabionet Mariona - - 2013
The lipid-rich stratum corneum functions as a barrier against pathogens and desiccation inter alia by an unbroken meshwork of extracellular lipid lamellae. These lamellae are composed of cholesterol, fatty acids and ceramides in an equimolar ratio. The huge class of skin ceramides consists of 3 groups, I) "classical" long and ...
Khan Haseeb A HA Department of Biochemistry, College of Science, King Saud University, Riyadh, Saudi - - 2014
Skin lipids play an important role in the regulation of cutaneous water loss (CWL). Earlier studies have shown that Saudi desert birds exhibit a tendency of reduced CWL than birds from temperate environment due to adaptive changes in composition of their skin lipids. In this study, we used thin-layer chromatography ...
Rosas-Ramírez Daniel - - 2013
Native to tropical America, Ipomoea batatas has been cultivated for over 5000 years in Mexico. The yellow-skinned tuber crop variety, with an orange flesh, has a higher nutritional value than potato. Raw sweet potato can cause a purge due to its resin glycoside content. Purification of the chloroform-soluble resin glycosides ...
Vávrová KateĊ™ina - - 2013
Mutations in the filaggrin gene (FLG) are strongly associated with common dermatological disorders such as atopic dermatitis. However, the exact underlying pathomechanism is still ambiguous. Here, we investigated the impact of FLG on skin lipid composition, organization and skin acidification using a FLG knock down (FLG-) skin construct. Initially, sodium/hydrogen ...
Regensburger Johannes - - 2013
UVA radiation plays an important role for adverse reactions in human tissue. UVA penetrates epidermis and dermis of skin being absorbed by various biomolecules, especially endogenous photosensitizers. This may generate deleterious singlet oxygen ((1)O2) that oxidizes fatty acids in cell membranes, lipoproteins, and other lipid-containing structures such as the epidermal ...
Tawada Chisato - - 2013
Ceramide (CER) with long-chain fatty acids (FAs) in human stratum corneum (SC) is important for the skin barrier functions. Changes in the CER profile have been associated with abnormal permeability of dermatoses such as atopic dermatitis (AD) and psoriasis. In addition, interferon-γ (IFN-γ) has been known to be abundant in ...
Sonsmann F K - - 2013
Skin cleansers for occupational use are manufactured for different types and degrees of soiling without common, legally binding requirements for product testing. This leads to different, manufacturer-specific test methods and a lack of comparable information on skin cleansing products. The aim of this investigation was to validate a newly developed ...
Dahlin Jakob - - 2013
Trifluoroacetic acid is a very strong carboxylic acid. The acid has been suspected to have similar toxic effects as hydrofluoric acid on skin contact. Hydrofluoric acid is highly toxic, owing to skin penetration by fluoride ions. A spill of hydrofluoric acid on the skin may be fatal. As trifluoroacetic acid ...
Dong Xiao-Qian - - 2013
We have established a simple method for preparing large quantities of A-type dimers from peanut skin and persimmon for further structure-activity relationship study. Peanut skins were defatted with hexane and oligomeric proanthoancyaindins were extracted from it with 20% of methanol, and the extract was fractionated with ethyl acetate. Persimmon tannin ...
Casas J W - - 2013
The aim of this study was to determine if the EpiDerm™ reconstructed human skin model (MatTek Corp.) could be an acceptable alternative to the ISO 10993-required rabbit skin irritation test for assessing medical device biocompatibility. Eleven medical device polymers were tested. Four extracts were prepared per polymer, two each with ...
Fischer Carol L - - 2013
Lauric acid (C12:0) and sapienic acid (C16:1Δ6) derived from human sebaceous triglycerides are potent antimicrobials found at the human skin surface. Long-chain bases (sphingosine, dihydrosphingosine and 6-hydroxysphingosine) are also potent and broad-acting antimicrobials normally present at the skin surface. These antimicrobials are generated through the action of ceramidases on ceramides ...
Webb David V - - 2013
The ingestion of large amounts of boric acid, a component of household insecticides, is a rare occurrence, characterized by a diffuse desquamative skin eruption, neutropenia, thrombocytopenia, delirium, acute renal failure and prolonged ileus. A 56-year-old male with a history of multiple previous suicide attempts was witnessed ingesting household roach killer ...
Fathi-Azarbayjani Anahita A Department of Pharmacy, National University of Singapore, Block S4, level 2, Science Drive 4, 117543, Singapore. ; Department of Medicine, Urmia University of Medical Sciences, Urmia, 5756115111, - - 2013
Physical UV absorbers such as titanium dioxide or zinc oxide have been found to be highly protective against ultraviolet radiation. Sun protection factor depends on the accumulation of the minerals on the skin. UV-absorbing agents must accumulate within the upper skin layers in order to provide a dense light-absorbing layer ...
Fallah Arani S - - 2013
Psoriasis vulgaris is a T-cell mediated disease that affects 2-3% of the worldwide white-skinned population. Fumaric acid esters are mentioned as an effective therapy for moderate-to-severe psoriasis vulgaris in adult patients in the new guidelines for psoriasis treatment. To obtain an insight into the use of fumaric acid esters by ...
Roy Amit A Department of Pharmaceutical Sciences, Columbia Institute of Pharmacy, Tekari, Raipur, Chhattisgarh, - - 2013
Cosmetics comprising either natural or synthetic components are used almost regularly and universally in different forms to enhance the beauty. The utmost disclosure of human membrane to sunlight and environmental pollution results in the exhibition of free radical, that react with deoxyribonucleic acid, proteins and fatty acids, causation oxidative destruction ...
Watabe Akiko - - 2013
Amino acids (AAs) play important roles in maintaining an optimal hydration state of stratum corneum (SC) as a natural moisturizing factor (NMF). Recently, however, we have reported that lactate and potassium significantly affect the hydration state of SC. To explore the source of lactate and potassium in SC, we compared ...
Juzeniene Asta - - 2013
5-Aminolevulinic acid (ALA) or its esters mediated photodynamic therapy (PDT) is the most widely practiced form of PDT in dermatology. One of its advantages is that undesirable photosensitization lasts only for 24-48h. In order to optimize ALA-PDT it is necessary to understand the mechanisms of intracellular production and clearance of ...
Sahm D F - - 2013
Clinical development of CEM-102 (fusidic acid) has recently begun in the United States for the treatment of acute skin infections. To support this development the in vitro activity of fusidic acid against important S. aureus clones and resistance phenotypes was determined. Against 51 such isolates, the modal fusidic acid MIC ...
Juzeniene Asta - - 2013
Folate is essential for cell division and growth. Deficiency is linked to birth defects, magaloblastic anaemia, cardiovascular disease, etc. Folic acid is a synthetic form of folate and is used to fortify food and in supplements. In aqueous solutions, in blood and even in human skin, folic acid may be ...
Lønne G K - - 2013
OBJECTIVE: There is an increasing demand for scientifically documented over-the-counter products on the cosmetic market. Salmon eggs are rich in proteins, vitamins, and minerals with anti-oxidative and anti-inflammatory properties, as well as free amino acids and lipids documented to be beneficial for skin. Of the fatty acids, several are commonly ...
Sae-Leaw Thanasak - - 2013
Changes in lipids, lipoxygenase activity and fishy odour development in the skin of Nile tilapia (Oreochromis niloticus) during iced storage of 18days were monitored. Triacylglycerol content of skin decreased with coincidental increases in free fatty acid, monoacylglycerol, diacylglycerol and phospholipid contents during storage (p<0.05). During iced storage, peroxide value increased ...
Verma Shivani - - 2013
The occurrence of topical fungal infections is increasing nowadays. Cutaneous fungal infections like cutaneous candidiasis are more prominent in patients associated with AIDS. Current available strategies for the treatment of cutaneous fungal infections are creams or gels which show various adverse effects on skin along with systemic absorption. These drawbacks ...
Park Sung-Il - - 2013
This work describes the use of a novel transepidermal drug carrier system composed of phospholipids and amphiphilc poly(amino acid)s. We polymerized poly(asparagine) grafted with octadecylamine (PAsn-g-C18), poly(aspartic acid) grafted with octadecylamine (PAsp-g-C18), and poly(aspartic acid) grafted with phytosphingosine (PAsp-g-PHS). We then prepared polymer hybridized liposomes (PHL) anchored with alkyl grafted ...
Fiume Monice M - - 2013
Cocamide diethanolamine (DEA) and some of the other diethanolamides are mainly used as surfactant foam boosters or viscosity increasing agents in cosmetics, although a few are reported to be used as hair and skin conditioning agents, surfactant-cleansing or surfactant-emulsifying agents, or as an opacifying agent. The Cosmetic Ingredient Review (CIR) ...
Haddican Madelaine - - 2013
Burning and/or stinging is one of the most common concerns expressed by patients using topical therapies for treatment of dermatologic disorders. Topical lactic acid preparations often are used to treat dry scaly skin. In this study, we compared the level of burning/stinging reported by participants with application of lactic acid ...
Maksymiak Magdalena - - 2013
RATIONALE: Currently, most of the antioxidants and free radical neutralizers used in cosmetic compositions are absorbed quickly into deeper layers of skin, and then carried away by the blood stream. It would be beneficial to delay the penetration of antioxidants to the deeper layers of skin to control their delivery ...
Weise Christin - - 2013
BACKGROUND: Oral administration of specific food ingredients can modify mucosal and systemic inflammatory processes. Such food components are fatty acids or carbohydrates. Nevertheless, little is known about the impact of oral administration of polyunsaturated fatty acids (PUFA) and non-digestible oligosaccharides on allergen-induced dermatitis. METHOD: In this pilot study, skin inflammation ...
Anderson Austen - - 2013
Contact dermatitis to topical tretinoin or retinoic acid is rarely described. We outline the case of a 20-year-old woman presenting with bilateral periorbital dermatitis against the background of longstanding use of retinoic acid for the ocular complications of toxic epidermal necrolysis. Patch testing confirmed a contact allergy to retinoic acid ...
Campanati A A Dermatology Clinic, Department of Clinical Medicine and Biotechnology, Polytechnic University of Marche, Ancona, Italy. - - 2013
Several studies have demonstrated that ozonated oil is effective on cutaneous wound healing. This in vivo study has been conducted to evaluate the clinical effect of the topical application of ozonated oil for 12 weeks on second-degree skin burns. A total of 30 patients suffering from second-degree skin burns in ...
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